Folate receptor alpha COPII (Coat 2) Mediated Vesicle Transport CargoCOPI-mediated concentration anterograde in the ER transport

Prelamin-A/C Signaling by BRAF and RAF fusions STAT6-mediatedDownstream signal induction transduction of chemokines 15-hydroxyprostaglandin dehydrogenase Reactions[NAD+] specific to the complex N-glycan synthesis pathway Signal transducer and activatorSynthesis of transcription of Lipoxins (LX)6 Activation of SMO TFAP2 (AP-2) family regulatesGlycoprotein transcription hormones of growth factors alpha and chaintheir receptors Solute carrierTransport organic anionof organic transporter anions family member 1B1 GlycoproteinThyroxine hormones biosynthesis Recycling of bile acids and salts Beta-arrestin-1 Mineralocorticoid biosynthesis Solute carrier organic anion transporter family member 1B3 5-lipoxygenase/FLAP Androgen biosynthesis

Matrix metalloproteinase (2 and 3) Oxygen-dependentRegulation asparagineNeddylation of hydroxylation expression byof Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Antigen processing: Ubiquitination & ProteasomePTK6Keap1/Nrf2 degradation promotes HIF1A stabilization Interleukin-4 andCollagenase 13 signaling

Aminopeptidase Hypoxia induciblePTK6 factors; Expression HIF-1-alpha, HIF-2-alpha

Post-translational modification: synthesis of GPI-anchored Ub-specific processing proteases

Folate receptor beta

Phospholipase A2 group 1B ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Signaling by NODAL TGF-betaCircadian Downregulationreceptor Clock signaling of TGF-betaactivates SMADsreceptor signaling CaseinHistone-lysine N-methyltransferase, I/MDM2 H3 lysine-9 specific 3 Metabolism of folate and pterines BMAL1:CLOCK,NPAS2 activates circadian gene expressionHDACs deacetylate histones Regulation of TP53 Activity through Methylation Proton-coupled folate transporter Signaling by Activin SUMOylation of transcription factors XBP1(S) activates chaperone genesOncogene Induced Senescence Mothers against decapentaplegic homologRegulation 3 of TP53 Degradation Iron uptake and transport TGFBR1 KDSMAD4 Mutants MH2 in Domain Mutants in Cancer EGFREPH-ephrin Transactivation mediated by repulsionGastrin of cells Stabilization of p53 RUNX3 regulates p14-ARFRUNX3SMAD2/3 regulates BCL2L11 (BIM) Motif RUNX3transcription SUMOylationMutants regulates in Cancer of CDKN1Achromatin organization transcription proteins SMAD2/3 MH2 Domain Mutants in Cancer Caspase-mediated cleavage of cytoskeletal proteins Dihydrofolate reductase TP53 Regulates Transcription of Caspase ActivatorsCaspase-6 and CaspasesCaspase-7 NR1D1 (REV-ERBA) represses RORA activatesCREB-binding gene expression protein/p53 Apoptotic cleavage of cellular proteins NoRC negativelyDownregulation regulates rRNA expressionof SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionRNA Polymerase I Transcription InitiationOxidative Stress Induced Senescence Activation of Matrix Metalloproteinases Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Inactivation, recovery and regulation of the phototransduction cascade Ovarian tumor domain proteases Regulation of TP53 Activity through Acetylation Activation of E2F1 target genesDegradation at G1/S of the extracellular matrixFactors involved in megakaryocyte development and platelet production Thymidylate synthase Association of TriC/CCT with target proteins during biosynthesis Constitutive Signalingp75NTR bynegatively NOTCH1 regulates HD+PEST cell DomainTP53 cycle viaRegulates Mutants SC1 Transcription of DNA Repair Transcription of E2F targets under negative control by DREAM complex InterconversionRibonucleoside-diphosphate of nucleotide di- and reductase triphosphatesConstitutive PurineM2 Signaling chain ribonucleoside by NOTCH1Histone monophosphate PEST Domain biosynthesis Mutants deacetylase Pre-NOTCH Transcription and Translation G0 and Early G1 DeactivationFormation of the beta-catenin of the beta-catenin:TCF transactivating transactivating complex complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 NOTCH1 IntracellularCilium Assembly Domain RegulatesPPARA activatesTranscription gene expression Proto-oncogene c-JUN Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models ActivationFCERI of mediated the AP-1 MAPKfamily activationof transcription factors Phase I -Xenobiotics Functionalization of compounds SUMOylation of DNA damage response and repair proteins Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Activation of the pre-replicativeTP53 complex Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Butyrylcholinesterase RHO GTPases Activate Formins MAPK6/MAPK4 signaling Collagen degradation APC/C:Cdh1 mediated degradation of Cdc20 and otherActivation APC/C:Cdh1 of anterior targeted HOX proteins genes inin latehindbrain mitosis/early developmentMitotic G1 Prometaphase during early embryogenesis DNA repairTranscriptional protein activationRAD52 homologof mitochondrial biogenesis PhosphorylationMAPK3 (ERK1)of proteinsMitotic activation involved Telophase/Cytokinesis in G1/S transition by active E:Cdk2 complexes Activated PKN1 stimulates transcription of AR (androgen receptor) regulatedActivation genes of ATR KLK2 in response and KLK3 to replication stress Mitotic Metaphase/Anaphase Transition Heat shock protein beta-1 Transcriptional regulation HDRof white through adipocyte Single Stranddifferentiation AnnealingUptake (SSA) and function of anthrax toxins Separation of Sister ChromatidsRegulationCyclin E associated of PTEN gene events transcription during G1/S transition Cdc20:Phospho-APC/C mediated degradation of Cyclin AAUF1 (hnRNP D0) binds and destabilizes mRNA PTK6 Regulates Cell Cycle RepressionCDK-mediated of WNT target phosphorylation genes and removal of Cdc6 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes Golgi CisternaeActivation Pericentriolar of NIMA Stack NEK9, Reorganization NEK6, NEK7 Regulation ofCyclin APC/C A/B1/B2 activatorsCondensation associated between of events Prometaphase G1/S during and early G2/M anaphase transition NuclearPolo-like Pore kinase ComplexCondensation mediated (NPC) events of Disassembly Prophase Chromosomes Cyclin-dependentE2F-enabledPhosphorylation inhibition of pre-replication of theG2/M APC/C DNA kinasecomplex replication formation checkpoint 1/cyclin B DEx/H-box helicases activate typeCD209 I IFN (DC-SIGN) and inflammatory signaling cytokines production DepolymerisationRegulation of of theActivity Nuclear at G2/M Lamina Transition TAK1 activates NFkB by phosphorylationRegulated proteolysis and activation of p75NTR of IKKs complex Resolution of Sister Chromatid Cohesion IkBAActivation variant of leads NF-kappaB to EDA-ID in B cells RIP-mediated NFkB activation via ZBP1 APC/C:Cdc20 mediatedMitotic degradation Prophase of Cyclin B MASTLPhosphorylation Facilitates Mitoticof Emi1 Progression DownstreamCLEC7A/inflammasome TCR signaling pathway TRAF6 mediated NF-kB activation NuclearIKBKG deficiency factor causes anhidrotic NF-kappa-BCLEC7A ectodermal (Dectin-1) dysplasia signaling with compleximmunodeficiency (EDA-ID) (via TLR) NF-kB is activated and signals survival MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1FCERIInterleukin-1 familymediated signalingprocessing NF-kB activation

Regulation of pyruvate dehydrogenase (PDH) complex Import of palmitoyl-CoA into the mitochondrial matrix CDT1 association with the CDC6:ORC:originSignaling complex by Retinoic Acid Association of licensingRemoval factors of licensing with the factorspre-replicative from origins complexPPAR delta/gamma Geminin