Biomarker Discovery Comprehensive Crownbio’S Programs

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Biomarker Discovery Comprehensive Crownbio’S Programs

Biomarker Discovery Increase your success rate by bridging discovery knowledge to clinical results Gain in-depth biological insights and make RATE data-informed trial decisions through Biomarker haracolo stud to Discovery. De-risk therapeutic development by assess and confir oA identifying robust and sensitive biomarkers early in drug development. Maximize your clinical success rate by incorporating biomarkers into your drug development programs. CrownBio’s comprehensive Biomarker Discovery enables you to: BUILD • Corroborate clinical-preclinical data. Statistical odels to interret haracolo data • Evaluate the predictive value of potential biomarkers. • Identify genomic and proteomic signatures corresponding to treatment response. • Rescue previously ‘unsuccessful’ drugs. • Improve patient stratification. Discover and validate biomarkers through our integrated platform encompassing: SCR AATE • Portfolio of well-characterized in vivo, ex vivo, and in vitro models as Hothesis ree ioarer discovery reliable, clinically relevant test systems for functional and efficacy evaluation. • Comprehensive menu of validated genomic and proteomic assays to understand drug MoA. • Extensive datasets collected over decades of research covering thousands of models, including growth curves, sequencing data, and pharmacological data including mouse clinical trials. • Proprietary bioinformatics solutions using in-house and public datasets OPTIMIZE enabling systematic analysis of genomics and proteomics. Clinical trial desin • Expert in-house team to assist with experimental design, high complexity analyses, and result interpretation. Contact Sales Schedule Scientific Consultation Additional Resources 1.0 Version US: +1.855.827.6968 Request a consultation to discuss Read supporting publications, white UK: +44 (0)870 166 6234 your project. papers, watch presentations, and more. [email protected] [email protected] crownbio.com/resources +1.855.827.6968 | [email protected] | www.crownbio.com.

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Technical Considerations and Protocol Optimization for Neonatal Salivary Biomarker Discovery and Analysis
PERSPECTIVE published: 26 January 2021 doi: 10.3389/fped.2020.618553 Technical Considerations and Protocol Optimization for Neonatal Salivary Biomarker Discovery and Analysis Elizabeth Yen 1,2, Tomoko Kaneko-Tarui 1 and Jill L. Maron 1,2* 1 Mother Infant Research Institute at Tufts Medical Center, Boston, MA, United States, 2 Division of Newborn Medicine, Tufts Children’s Hospital, Boston, MA, United States Non-invasive techniques to monitor and diagnose neonates, particularly those born prematurely, are a long-sought out goal of Newborn Medicine. In recent years, technical advances, combined with increased assay sensitivity, have permitted the high-throughput analysis of multiple biomarkers simultaneously from a single sample source. Multiplexed transcriptomic and proteomic platforms, along with more comprehensive assays such as RNASeq, allow for interrogation of ongoing physiology and pathology in unprecedented ways. In the fragile neonatal population, saliva is an ideal bioﬂuid to assess clinical status serially and offers many advantages over more Edited by: invasively obtained blood samples. Importantly, saliva samples are amenable to analysis Diego Gazzolo, SS Annunziata Polyclinic Hospital, on emerging proteomic and transcriptomic platforms, even at quantitatively limited Chieti, Italy volumes. However, biomarker targets are often degraded in human saliva, and as a mixed Reviewed by: source bioﬂuid containing both human and microbial targets, saliva presents unique Anne Lee Solevåg, challenges for the investigator. Here, we provide insight into technical considerations Akershus University Hospital, Norway Trent E. Tipple, and protocol optimizations developed in our laboratory to quantify and discover neonatal University of Oklahoma Health salivary biomarkers with improved reproducibility and reliability. We will detail insights Sciences Center, United States learned from years of experimentation on neonatal saliva within our laboratory ranging *Correspondence: Jill L.
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Emerging Role and Recent Applications of Metabolomics Biomarkers in Obesity Disease Cite This: RSC Adv.,2017,7, 14966 Research
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Metabolomics to Provide Biomarkers and Mechanistic Insights
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Proteomic and Genomic Technologies for Biomarker Discovery Where Are the Biomarkers? Vathany Kulasingam and Eleftherios P
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Metabolomic Profiling of Lipids for Biomarker Discovery
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Biomarker Discovery Using SELDI Technology
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