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D i a g n o s t i c s Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:11 Seite 1

Product Catalogue 2016 / 17 HPLC & LC-MS/MS

RECIPE CHEMICALS + INSTRUMENTS GmbH Dessauerstraße 3 · 80992 Munich/Germany Phone: +49 / 89 / 54 70 81 - 0 · Fax: - 11 www.recipe.de · [email protected] Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:12 Seite 2

RECIPE

Who we are

RECIPE was founded in Munich in 1982 and is one of the leading companies in clinical HPLC and LC-MS/MS diagnostics today.

RECIPEʼs success in more than 30 years has mainly been defined by the consistent implementation of a customer-oriented, stringent quality po li cy. Therefore ”quality” is not a mere phrase for us. As supplier of diagnostic products we are rather aware of the special responsibility towards our customers, and ulti- mately, the patients. With our premium quality products and our competent and fast service, we are a reliable partner in laboratory diagnostics.

All products are designed, developed and manufactured in our facilities located in Munich. All our com- pany processes are controlled by a certified quality ma nagement system (ISO 13485 and ISO 9001). Fur thermore we are regularly participating in na tio nal and European proficiency schemes to support the quality assurance of our calibrator and control materials.

Solutions for Clinical Diagnostics

It is our goal to convince with quality, performance and innovation also in the future. In this product cata - logue you will find a series of new and innovative products, which are expanding our current portfolio especially in the sectors of therapeutic drug monitoring and automated LC-MS/MS analytics.

We would like to thank all our customers with the new edition of this product catalogue and we are looking forward to a successful joint future in the coming years.

Alfred Bauer, General Manager

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New Products ...... 6 - 7

HPLC Complete Kits ClinRep® Diagnostics ...... 10 - 73 ClinRep® Therapeutic Drug Monitoring . . . 74 - 93 ClinTox® Human Biomonitoring . . . . . 94 - 103

Photometric Complete Kits ClinEasy® Photometric Complete Kits . 104 - 113

LC-MS/MS Complete Kits ClinMass® Diagnostics ...... 116 - 127 ClinMass® Therapeutic Drug Monitoring . 128 - 151 ClinSpot® Dried Blood Spot Analysis . . 152 - 159

LC-MS/MS Opti Mix and IS ClinMass® Optimisation Mixes and Internal Standards ...... 160 - 171

Quality Assurance ClinTest® Solutions ...... 174 - 181 ClinCal® Calibrators ...... 182 - 209 ClinChek® Controls ...... 210 - 241

Index ...... 242 - 244

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New Products

LC-MS/MS Complete Kits

ClinMass® Diagnostics Biogenic Amines Free Metanephrines in Plasma – on-line Analysis ...... 120 - 121 Vitamin-Status 25-OH Vitamin D2/D3 in Plasma and Serum, advanced LC-MS/MS Opti Mix and IS – automated on-line Analysis ...... 126 - 127

ClinMass® Optimisation Mixes and Internal Standards ClinMass® Therapeutic Drug Monitoring Optimisation Mix for Antidepressants ...... 164 Immunosuppressants Optimisation Mix for Antiepileptic Drugs ...... 164 Immunosuppressants in Whole Blood, advanced Optimisation Mix for Metanephrines ...... 166 – automated on-line Analysis ...... 130 - 131 Optimisation Mix for Tricyclic Antidepressants ...... 167 Internal Standards for Amino Acids and Acylcarnitines ...... 168 Internal Standards for Antidepressants ...... 168 TDM Kit System Internal Standards for Antiepileptic Drugs ...... 168 Add-on Sets for TDM Platform . . . . . 132 - 133 Internal Standard for Metanephrines ...... 170 Benzodiazepines (BZP) ...... 134 - 135 Internal Standards for Tricyclic Antidepressants ...... 171 Tricyclic Antidepressants (TCA) ...... 136 - 137 Antiepileptic Drugs (AED) ...... 138 - 139 Antidepressants (ADP) ...... 140 - 141 Quality Assurance

® TDM Kit System, on-line ClinCal Calibrators Serum Calibrator Set for Antidepressants (Level 0 – 3) ...... 204 Add-on Sets for TDM Platform, Serum Calibrator Set Antiepileptics 5 (Level 0 – 3) ...... 205 on-line ...... 142 - 143 Serum Calibrator Set for Metanephrines (Level 0 – 4) ...... 206 Benzodiazepines (BZP) ...... 144 - 145 Serum Calibrator Set for Steroids (Level 0 – 6) ...... 207 Tricyclic Antidepressants (TCA) ...... 146 - 147 Serum Calibrator Set for Tricyclic Antidepressants (Level 0 – 3) ...... 208 Antiepileptic Drugs (AED) ...... 148 - 149 Antidepressants (ADP) ...... 150 - 151 ClinChek® Controls Dried Blood Spot Control (DBS) for Amino Acids and Acylcarnitines, Level I, II ...... 240 Serum Control for Antidepressants, Level I, II ...... 235 ClinSpot® Dried Blood Spot Analysis Serum Control Antiepileptics 5, Level I, II ...... 236 Neonatal-Screening Serum Control for Metanephrines, Level I, II, III ...... 237 Amino Acids and Acylcarnitines ...... 154 - 155 Serum Control for Steroids, Level I, II, III ...... 239 Amino Acids and Acylcarnitines with Filter-Plates ...... 156 - 157 Serum Control for Tricyclic Antidepressants, Level I, II ...... 239

6 7 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:13 Seite 8 HPLC

HPLC Complete Kits

ClinRep® Diagnostics

ClinRep® Therapeutic Drug Monitoring

ClinTox® Human Biomonitoring

ClinRep® HPLC Complete Kits are intended for diagnosis and therapeutic drug monitoring (TDM) in clinical, toxicological and forensic laboratories. ClinTox® HPLC Complete Kits are designed for human biomonitoring (HBM) in laboratories for occupational medicine.

Our kits can be used with any conventional HPLC system. A complete kit contains all components required for analysis, such as buffers, rea gents for sample preparation, standards, and a matrix calibrator. Start accessories (such as guard-, SPE-, and analytical columns), matrix controls, and further accessories are additionally available.

9 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:13 Seite 10 Diagnostics

HPLC Complete Kits

ClinRep® Diagnostics for clinical, toxicological and forensic analysis

Alcoholism, Drug Abuse Metabolic Diseases CDT in Serum Aromatic Amino Acids in Plasma . . . . . 44 - 45 – Manual sample preparation ...... 12 - 13 Homocysteine in Plasma ...... 46 - 47 – on-line Analysis ...... 14 - 15 Hydroxyproline in Urine ...... 48 - 49 – Automated on-line Analysis ...... 16 - 17 Porphyrins Differentiated in Urine . . . . 50 - 51 Biogenic Amines Oxidative Stress Catecholamines in Plasma ...... 18 - 19 β-Carotene in Plasma / Serum ...... 52 - 53 Catecholamines in Urine Coenzyme Q10 in Whole Blood / – Manual sample preparation ...... 20 - 21 Plasma / Serum ...... 54 - 55 – with Gilson® ASPEC™ XL ...... 22 - 23 Malondialdehyde in Plasma / Serum . . . 56 - 57 – with HTA, Model HT400E ...... 22 - 23 Vitamin C in Plasma ...... 58 - 59 – on-line Analysis ...... 24 - 25 Vitamin Status Metanephrines in Urine Vitamin A and E in Plasma ...... 60 - 61 – Manual sample preparation ...... 26 - 27 Vitamin B1 in Whole Blood ...... 62 - 63 – with Gilson® ASPEC™ XL ...... 28 - 29 Vitamin B2 in Whole Blood ...... 64 - 65 – with HTA, Model HT400E ...... 28 - 29 Vitamin B6 in Plasma / Whole Blood . . . 66 - 67 Serotonin in Plasma ...... 30 - 31 Vitamin B1, B2, B6 (Combikit) ...... 68 - 69 Serotonin in Urine ...... 32 - 33 25-OH Vitamin D2 / D3 VMA, HVA, 5-HIAA in Urine in Plasma and Serum – Manual sample preparation ...... 34 - 35 – with HPLC ...... 70 - 71 – with Gilson® ASPEC™ XL ...... 36 - 37 – with UHPLC ...... 72 - 73 – with HTA, Model HT400E ...... 36 - 37 Diabetes, Hemoglobins HbA1c in Whole Blood – with DiamatTM ...... 38 - 39 – with VariantTM ...... 40 - 41 Hemoglobin Variants and β-Thalassemia Screening in Whole Blood ...... 42 - 43

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CDT (carbohydrate deficient transferrin) is the most Alcoholism, Drug Abuse Native sample, normal range Native sample, pathological range specific parameter for chronic alcohol abuse. The Diagnostics ClinRep® HPLC Complete Kit for CDT provides a 30 30

unique chromatographical resolution compared to 7.73 CDT in Serum 25 25 7.69 other commercially available test kits. The analytical 20 20

method correlates with the candidate reference 15 15

10 5.98

10 8.66 method of the IFCC-CDT-WG* and ensures a reliable Test Data 8.75 4.25 6.71 6.85

5 6.22 Intensity (mV) Intensity (mV) 9.65

5 9.57 separation of all relevant transferrin isoforms (a-, LOD: 0.1 %* 0 0 mono-, di-,…, hexasialotransferrin). This applies in LLOQ: 0.3 %* 0 1 2 3 4 5 6 7 8 9 10 0 1 2 3 4 5 6 7 8 9 10 particular for disialotransferrin, the most important Intraassay precision: 4.2 % CDT isoform. Alternatively to this method with manual Interassay precision: 4.3 % Retention Time (min) Retention Time (min) ® sample preparation, ClinRep Complete Kits for on- * depending on the amount of total transferrin Disialotransferrin: 6.22 min, Trisialotransferrin: 6.85 min, Asialotransferrin: 4.25 min, Disialotransferrin: 5.98 min, and on detector sensitivity line analysis and automated on-line analysis via 96- Tetrasialotransferrin: 7.73 min, Pentasialotransferrin: 8.75 min, Trisialotransferrin: 6.71 min, Tetrasialotransferrin: 7.69 min, well plates are available (see pages 14 - 17). Hexasialotransferrin: 9.65 min Pentasialotransferrin: 8.66 min, Hexasialotransferrin: 9.57 min * Working group of the IFCC for the international standardisation HPLC Parameters of CDT measurement. Pump: ternary gradient pump, Ordering Information flow rates: 1.2, 2.0 ml/min Order No. Description Quantity Injection volume: 400 - 500 μl 21000 ClinRep® Complete Kit for CDT in Serum for 100 assays 1 pce. Injection interval: 20 min UV/VIS-Detector: 460 nm Kit Components (order no. 21000): HPLC-Thermostat: 40 °C 21007 Mobile Phase A 3 x 21007 (3 x 2000 ml) 21008 Mobile Phase B 2000 ml 21009 Mobile Phase C 2000 ml Sample Preparation 21020 Sample Preparation Vials 2 x 21020 (2 x 100 pcs.) 21021 Stabilising Reagent S 3 ml Stabilisation/Precipitation: 21022 Precipitant P1 1 ml 21023 Precipitant P2 2 ml 30 μl 10 μl mixture of 150 μl serum 21024 Diluting Solution D 100 ml Stabilising Reagent S Precipitants P1+P2 Manual 1 pce. ➜ 1. incubate (30 min, 4 °C) 2. centrifuge Quick Reference 1 pce.

Dilution: Optional Components: 100 μl 1.0 ml Diluting 21014 Test Solution 15 ml supernatant Solution D Start Accessories: ➜ 21030 Analytical Column with test chromatogram 1 pce. HPLC Analysis: 21032 Cartridge incl. 1 precolumn 1 pce.

Inject 400 - 500 μl Refill Service: 21031 Analytical Column with test chromatogram (original column needs to be returned) 1 pce.

Accessories: 21033 Precolumns 5 pcs. ➜ Unique chromatographical FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FW3000 Fixed-Wavelength-VIS-Detector (460 nm), complete 1 pce. resolution RC2002 Sodium-Hypochlorite-Solution (5 %) 12 ml

ClinChek® Controls: 21080 Serum Control, lyophil., Level I 10 x 1 ml ➜ Quantification of all relevant 21081 Serum Control, lyophil., Level II 10 x 1 ml transferrin isoforms 21082 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml (incl. hexasialotransferrin)

➜ Baseline-separation of disialotransferrin

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This ClinRep® Complete Kit is designed for the fast Alcoholism, Drug Abuse Native sample, normal range Native sample, pathological range analysis of CDT with on-line SPE HPLC. It features Diagnostics

40 40 Diagnostics an injection interval of 9.5 min only and provides a 6.17 6.21 unique chromatographical resolution compared to CDT in Serum – 30 30 other commercially available test kits. Analogously to our kit with manual sample preparation (see pages on-line Analysis 20 20

12 - 13), the on-line procedure correlates with the 7.15 7.13 5.19 4.52 5.17 Intensity (mV) Intensity (mV)

10 10 7.84 3.02 4.50

candidate reference method of the IFCC-CDT-WG*. 7.86 Prior to the sample injection, a simple dilution step is Test Data LOD: 0.1 %* 0 0 required (”sample pretreatment“, see below). Alter na - 0 1 2 3 4 5 6 7 8 0 1 2 3 4 5 6 7 8

tively, the dilution can be performed automated via LLOQ: 0.3 %* Retention Time (min) Retention Time (min) 96-well plates. For this purpose an additional ClinRep® Intraassay precision: 4.5 % Interassay precision: 3.9 % Disialotransferrin: 4.50 min, Trisialotransferrin: 5.17 min, Asialotransferrin: 3.02 min, Disialotransferrin: 4.52 min, Complete Kit is available (see pages 16 - 17). Tetrasialotransferrin: 6.17 min, Pentasialotransferrin: 7.13 min, Trisialotransferrin: 5.19 min, Tetrasialotransferrin: 6.21 min, * Working group of the IFCC for the international standardisation * depending on the amount of total transferrin Hexasialotransferrin: 7.86 min Pentasialotransferrin: 7.15 min, Hexasialotransferrin: 7.84 min of CDT measurement. and on detector sensitivity

Ordering Information HPLC Parameters Order No. Description Quantity Pump 1: binary gradient pump, flow rate: 1.4 ml/min 21100 ClinRep® Complete Kit for CDT in Serum for 300 assays 1 pce. Pump 2: isocratic pump, Kit Components (order no. 21100): flow rate: 0.4 ml/min 21007 Mobile Phase A 3 x 21007 (3 x 2000 ml) Injection volume: 400 - 500 μl 21008 Mobile Phase B 2000 ml 21009 Mobile Phase C 2 x 21009 (2 x 2000 ml) Injection interval: 9.5 min 21120 Vials for Sample Pretreatment with Diluting Solution 6 x 21120 (6 x 50 pcs.) UV/VIS-Detector: 460 nm Manual 1 pce. HPLC-Thermostat: 40 °C Quick Reference 1 pce.

Optional Components: Sample Pretreatment 21014 Test Solution 15 ml

100 μl Serum Start Accessories: 21030 Analytical Column with test chromatogram 1 pce. 21032 Cartridge incl. 1 precolumn 1 pce. 1. incubate FK5820 Stainless steel prefilter holder 1 pce. Inject Vial with Diluting (30 min, 4 °C) FK7400 Inline-Filter (stainless steel sieve, free of dead volume) 1 pce. supernatant Solution (order 2. centrifuge (400 - 500 μl) no. 21120) ➜ Refill Service: 21031 Analytical Column with test chromatogram (original column needs to be returned) 1 pce.

Accessories: 21033 Precolumn 5 pcs. FK1102 Switching valve, Sykam (6-port/3-channel incl. electr. drive, PEEK) 1 pce. FK5810 PEEK tubing (connection of prefilter and column) 1 pce. ➜ One step sample One step FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. FK7340 Sealings and sieves 4 pcs. each pretreatment sample pretreatment! FW3000 Fixed-Wavelength-VIS-Detector (460 nm), complete 1 pce. RC2002 Sodium-Hypochlorite-Solution (5 %) 12 ml

ClinChek® Controls: 21080 Serum Control, lyophil., Level I 10 x 1 ml ➜ Fast analysis: injection 21081 Serum Control, lyophil., Level II 10 x 1 ml interval of 9.5 min only 21082 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml

➜ Unique chromatographical quality

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This ClinRep® Complete Kit is designed for the fully Alcoholism, Drug Abuse Native sample, normal range Native sample, pathological range automated analysis of CDT with liquid handling Diagnostics

40 40 Diagnostics sys tems and subsequent on-line SPE HPLC. The 6.17 6.21 analytical method correlates with the candidate CDT in Serum – 30 30 reference method of the IFCC-CDT-WG* and en - sures a reliable separation of all relevant transferrin Automated 20 20

isoforms (a-, mono-, di-, …, hexasialotransferrin). 7.15 7.13 5.19 4.52 5.17 Intensity (mV) Intensity (mV)

10 10 7.84 3.02 4.50

This applies in particular for disialotransferrin, the on-line Analysis 7.86 most important CDT isoform. An accurate calculation of the CDT value is ensured by baseline separation. 0 0 Test Data 0 1 2 3 4 5 6 7 8 0 1 2 3 4 5 6 7 8 * Working group of the IFCC for the international standardisation Retention Time (min) Retention Time (min) of CDT measurement. LOD: 0.1 %* LLOQ: 0.3 %* Disialotransferrin: 4.50 min, Trisialotransferrin: 5.17 min, Asialotransferrin: 3.02 min, Disialotransferrin: 4.52 min, Intraassay precision: 2.8 % Tetrasialotransferrin: 6.17 min, Pentasialotransferrin: 7.13 min, Trisialotransferrin: 5.19 min, Tetrasialotransferrin: 6.21 min, Hexasialotransferrin: 7.86 min Pentasialotransferrin: 7.15 min, Hexasialotransferrin: 7.84 min Interassay precision: 2.5 % * depending on the amount of total transferrin and on detector sensitivity Ordering Information Order No. Description Quantity HPLC Parameters 21200 ClinRep® Complete Kit for CDT in Serum for 300 assays 1 pce. Pump 1: binary gradient pump, flow rate: 1.4 ml/min Kit Components (order no. 21200): 21007 Mobile Phase A 3 x 21007 (3 x 2000 ml) Pump 2: isocratic pump, 21008 Mobile Phase B 2000 ml flow rate: 0.4 ml/min 21009 Mobile Phase C 2 x 21009 (2 x 2000 ml) 21221 Diluting Solution D 3 x 21221 (3 x 50 ml) Injection volume: 400 μl Manual 1 pce. Injection interval: 9.5 min Quick Reference 1 pce. UV/VIS-Detector: 460 nm Optional Components: HPLC-Thermostat: 40 °C 21014 Test Solution 15 ml

Start Accessories: Sample Pretreatment (Liquid Handling System) 21030 Analytical Column with test chromatogram 1 pce. Dilution: 21032 Cartridge incl. 1 precolumn 1 pce. FK5820 Stainless steel prefilter holder 1 pce. 500 μl Diluting Solution D 50 μl serum FK7400 Inline-Filter (stainless steel sieve, free of dead volume) 1 pce.

➜ Refill Service: 1. incubate (30 min, 4 °C) 2. centrifuge 21031 Analytical Column with test chromatogram (original column needs to be returned) 1 pce. on-line Analysis: Accessories: Inject 400 μl 21033 Precolumns 5 pcs. 21220 Deepwell plate 96/500μl 8 pcs. FK1102 Switching valve, Sykam (6-port/3-channel incl. electr. drive, PEEK) 1 pce. ➜ Fully automated method FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. FK7340 Sealings and sieves 4 pcs. each FW3000 Fixed-Wavelength-VIS-Detector (460 nm), complete 1 pce. RC2002 Sodium-Hypochlorite-Solution (5 %) 12 ml ➜ Fast analysis: injection ClinChek® Controls: interval of 9.5 min only 21080 Serum Control, lyophil., Level I 10 x 1 ml 21081 Serum Control, lyophil., Level II 10 x 1 ml 21082 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml

➜ Unique chromatographical resolution

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Epinephrine (E), norepinephrine (NE), and dopamine Biogenic Amines ClinChek® Plasma Control, Level I ClinChek® Plasma Control, Level II (D) are termed as catecholamines. The determina- Diagnostics tion of catecholamines is primarily used for helping 50 50 4.28 to detect and rule out pheochromocytomas in symp - 40 40 7.56 Catecholamines 7.55 to matic patients, i.e. in patients with persistent 30 30

hypertension. It is also used in order to help monitor 20 20 4.28

in Plasma 5.07

for recurrence when a pheochromocytoma has been 10 10 12.02 5.08 Intensity (mV) Intensity (mV) 12.05 discovered and removed. For these purposes, this 0 0 ClinRep® Complete Kit allows for a quick and safe Test Data -10 -10 quan ti fication of the catecholamines. The kit is easy Linearity: 10 - 2500 ng/l 0 2 4 6 8 10 12 14 0 2 4 6 8 10 12 14

to use and is characterised by an extraordinarily Recovery: 70 - 90 % Retention Time (min) Retention Time (min) good lower detection limit. LOD: 5 ng/l LLOQ: 10 ng/l Norepinephrine: 4.28 min, Epinephrine: 5.08 min, Norepinephrine: 4.28 min, Epinephrine: 5.07 min, IS: 7.55 min, Dopamine: 12.05 min IS: 7.56 min, Dopamine: 12.02 min Intraassay precision: 6.7 % (NE), 7.6 % (E), Ordering Information 6.1 % (D) Order No. Description Quantity Interassay precision: 5.3 % (NE), 4.2 % (E), 1000 ClinRep® Complete Kit for Catecholamines in Plasma for 250 assays 1 pce.

3.9 % (D) Kit components (order no. 1000): 1210 Mobile Phase 1000 ml 1011 Standard Solution 10 ml HPLC Parameters 1012 Internal Standard IS 15 ml Pump: isocratic pump, 1013 Plasma Calibrator, lyophil. 5 x 5 ml flow rate: 1.0 ml/min 1020 Sample Preparation Columns incl. elution vials 5 x 1020 (5 x 50 pcs.) 1021 Washing Solution W 3 x 1021 (3 x 250 ml) Injection volume: 40 μl 1022 Eluting Reagent E 30 ml Injection interval: 15 min Manual 1 pce. Quick Reference 1 pce. EC-Detector: potential: 500 mV, sensitivity: 10 nA Start Accessories: Temperature: 25 °C (or ambient) 1030 Analytical Column with test chromatogram 1 pce.

Accessories: Sample Preparation 1041 2 ml sample vial with cap for storing samples 50 pcs. 1042 Sampling system for Plasma Catecholamines (5 ml) 50 pcs. Extraction: 1060 Sample preparation column, empty with frit and cap 50 pcs. Apply 1 ml plasma and 50 μl Internal Standard IS 1061 250 μl elution vial with cap 50 pcs. to a sample preparation column 1070 Alumina oxide 5 g 1072 2 M Tris Buffer 250 ml ➜ wash (3 x 1 ml Washing Elution: Solution W) ClinChek® Controls: 8810 Plasma Control, lyophil., Level I 10 x 5 ml Elute with 120 μl Eluting Reagent E 8811 Plasma Control, lyophil., Level II 10 x 5 ml 8809 Plasma Control, lyophil., Level I, II 2 x 5 x 5 ml ➜ Reliable sample ➜ collect the eluate preparation HPLC Analysis: Inject 40 μl

➜ Quick and safe quantification

➜ Detection limit: 5 ng/l

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With this complete kit, the determination of norepin - Biogenic Amines ClinChek® Urine Control, Level I ClinChek® Urine Control, Level II Diagnostics ephrine (NE), epinephrine (E), and dopamine (D) is 600 600 performed from urine. The sample preparation fea- 500 500 tures particular user friendliness for laboratory rou- 4.89 12.93 Catecholamines 400 400 8.33

tine. For a safe and convenient check-up of the pH- 8.33 300 300 value prior to sample extraction, a special stabilising in Urine 12.92 200 200 reagent with colour indicator is available. The dis - 4.89 5.89 tinct indicator colouring assures the setting of the Intensity (mV) 100 Intensity (mV) 100 5.89

appropriate pH value range (pH 2 – 5). Alter na tively Test Data 0 0 Linearity: 2 - 1000 μg/l to this method with manual sample preparation, 0 2 4 6 8 10 12 14 0 2 4 6 8 10 12 14 ® RECIPE offers ClinRep Complete Kits for use with Recovery: 70 - 85 % Retention Time (min) Retention Time (min) automatic pipetting systems from Gilson® and HTA LOD / LLOQ: 1 μg/l / 2 μg/l Precision Norepinephrine: 4.89 min, Epinephrine: 5.89 min, Norepinephrine: 4.89 min, Epinephrine: 5.89 min, (see pages 22 - 23). IS: 8.33 min, Dopamine: 12.92 min IS: 8.33 min, Dopamine: 12.93 min Intraassay: 0.8 % (NE), 1.4 % (E), 1.7 % (D) Interassay: 2.0 % (NE), 2.3 % (E), 3.1 % (D) Ordering Information Order No. Description Quantity HPLC Parameters Isocratic Pump: flow rate: 1.0 ml/min 2000 ClinRep® Complete Kit for Catecholamines in Urine for 100 assays 1 pce.

Injection vol. / int.: 20 μl / 15 min Kit Components (order no. 2000): EC-Detector: pot.: 500 mV, sen.: 10 nA 1210 Mobile Phase 1000 ml 2011 Standard Solution 10 ml HPLC-Thermostat: 30 °C 2012 Internal Standard IS 3 ml 2013 Urine Calibrator, lyophil. 5 x 8 ml Sample Preparation 2020 Sample Preparation Columns 2 x 2020 (2 x 50 pcs.) 2021 Stabilising Reagent S 500 ml Addition of IS / pH adjustment: 2024 Eluting Reagent E 2 x 2024 (2 x 300 ml) 5 ml Stab. Reagent S 30 μl Internal Manual 1 pce. 3 ml urine (contains colour indic.) Standard IS Quick Reference 1 pce. ➜➜ adjust with 1 M NaOH, until the Start Accessories: indicator switches to yellow 2030 Analytical Column with test chromatogram 1 pce.

pH = 1.5 pH = pH2.5 = 3.5 pH = 4.5 pH = 5.5 pH = 6.0 pH = 8.0 Accessories:

+ NaOH - HCI ➜ ➜ FK4000 Column Rack (for 20 columns) 1 pce.

pH = 2.0 ® pH = 5.0 ClinChek Controls: pH < 2.0 2.0 < pH < 5.0 pH > 5.0 8820 Urine Control, lyophil., Level I 10 x 8 ml too acidic ok too alkaline 8821 Urine Control, lyophil., Level II 10 x 8 ml 8822 Urine Control, lyophil., Level I, II 2 x 5 x 8 ml Extraction:

Apply the whole sample on the sample preparation column

➜ ➜ Safe and convenient wash (HPLC water) pH-adjustment Elution: Apply 6 ml Eluting Reagent E ➜ ➜ Robust chromatography HPLC Analysis: Inject 20 μl

➜ Detection limit: 1 μg/l

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Catecholamines are important parameters for the Biogenic Amines Ordering Information diagnosis of pheochromocytomas. In addition to Order No. Description Quantity Diagnostics

® the ClinRep Complete Kit with manual sample 2200 ClinRep® Complete Kit for Catecholamines in Urine 1 pce. preparation (order no. 2000, see pages 20 - 21) Catecholamines in Urine with Gilson® ASPEC™ XL RECIPE offers two ClinRep® Complete Kits for for 100 assays ® automated sample preparation with robotic – with Gilson ASPEC™ XL Kit components (order no. 2200): systems from Gilson® and HTA. Kits for 100 and 1210 Mobile Phase 1000 ml – with HTA, Model HT400E 2011 Standard Solution 10 ml 500 assays are available for each system. 2012 Internal Standard IS 3 ml 2013 Urine Calibrator, lyophil. 5 x 8 ml 2220 Sample Preparation Columns 2 x 2220 (2 x 50 pcs.) Test Data 2021 Stabilising Reagent S 500 ml 2224 Eluting Reagent E 400 ml Test data are available on request Manual Quick Reference HPLC Parameters 2300 ClinRep® Complete Kit for Catecholamines in Urine 1 pce. Identical with order no. 2000, see pages 20 - 21 with Gilson® ASPEC™ XL for 500 assays

Sample Preparation* Kit components (order no. 2300): Manual sample pretreatment 5-fold amount of kit components with order no. 2200 (1210, 2011, ..., 2224) 5 x 2200 pH adjustment: 2400 ClinRep® Complete Kit for Catecholamines in Urine 1 pce. 5 ml Stabilising Reagent S with HTA, Model HT400E 3 ml urine (contains colour indicator) for 100 assays

➜ adjust with 1 M NaOH, until the Kit components (order no. 2400): indicator switches to yellow 1210 Mobile Phase 1000 ml

pH = 1.5 pH = pH2.5 = 3.5 pH = 4.5 pH = 5.5 pH = 6.0 pH = 8.0 2011 Standard Solution 10 ml

+ NaOH - HCI 2012 Internal Standard IS 2 x 2012 (2 x 3 ml) ➜ ➜ 2013 Urine Calibrator, lyophil. 5 x 8 ml 2420 Sample Preparation Columns 2 x 2420 (2 x 50 pcs.) pH = 2.0 pH = 5.0 2421 Stabilising Reagent S 250 ml pH < 2.0 2.0 < pH < 5.0 pH > 5.0 too acidic ok too alkaline 2424 Eluting Reagent E 250 ml FK6401 Sample vials, clear glass, 4ml 2 x FK6401 (2 x 100 pcs.) Automated sample preparation Manual 1 pce. Quick Reference 1 pce. with Gilson® ASPEC™ XL Addition of IS: 2500 ClinRep® Complete Kit for Catecholamines in Urine 1 pce. with HTA, Model HT400E Add 30 μl Internal Standard IS to the sample for 500 assays ➜ Kit components (order no. 2500): Extraction: 5-fold amount of kit components with order no. 2400 (1210, 2011, ..., FK6401) 5 x 2400

Apply 6 ml sample on the sample preparation column Start Accessories: 2030 Analytical Column with test chromatogram 1 pce. ➜ wash (HPLC water) ➜ Elution: Automated sample ClinChek® Controls: preparation 8820 Urine Control, lyophil., Level I 10 x 8 ml Apply 4 ml Eluting Reagent E 8821 Urine Control, lyophil., Level II 10 x 8 ml 8822 Urine Control, lyophil., Level I, II 2 x 5 x 8 ml ➜

HPLC Analysis: ➜ Test kits available for Inject 20 μl 100 or 500 assays * The indicated sample/reagent volumes are exemplified for the ASPEC™ XL. The corresponding data for the HT400E are available on request. ➜ Injection interval: 15 min

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This ClinRep® Complete Kit is designed for the Biogenic Amines ClinChek® Urine Control, Level I (+ 20 μl IS/ml urine) ClinChek® Urine Control, Level II (+ 20 μl IS/ml urine) con venient on-line SPE HPLC analysis of the cate- Diagnostics

cholamines. A time consuming manual sample pre- 300 300 paration is not required with this method. Prior to 250 250 12.85 Catecholamines 12.84 200 200

the on-line analysis the samples simply have to be 16.10 spiked with the internal standard (one step sample in Urine – on-line 150 16.11 150 100 100 pretreatment). 9.11

50 9.12 50 10.51 Intensity (mV) Intensity (mV) Analysis 0 10.52 0 -50 -50 8 9 10 11 12 13 14 15 16 17 18 19 20 8 9 10 11 12 13 14 15 16 17 18 19 20 Test Data Retention Time (min) Retention Time (min) Linearity: 3 - 1500 μg/l Recovery: 95 - 100 % Norepinephrine: 9.12 min, Epinephrine: 10.52 min, Norepinephrine: 9.11 min, Epinephrine: 10.51 min, LOD: 1 μg/l IS: 12.85 min, Dopamine: 16.11 min IS: 12.84 min, Dopamine: 16.10 min LLOQ: 3 μg/l Intraassay precision: 3.0 % (NE), Ordering Information 4.5 % (E), Order No. Description Quantity

0.8 % (D) 2100 ClinRep® Complete Kit for Catecholamines in Urine for 500 assays 1 pce. Interassay precision: 3.6 % (NE), Kit components (order no. 2100): 6.4 % (E), 2109 SPE-Buffer 4 x 2109 (4 x 2500 ml) 2.4 % (D) 2110 Mobile Phase 6 x 2110 (6 x 2500 ml) 2011 Standard Solution 10 ml 2113 Urine Calibrator (FD), lyophil. 5 x 5 ml HPLC Parameters Manual 1 pce. Pump 1 Quick Reference 1 pce.

(SPE-buffer): isocratic pump, Optional components: flow rates: 0.5, 2.0 ml/min 2012 Internal Standard IS 3 ml Pump 2 Start Accessories: (mobile phase): isocratic pump, 1232 Guard Column Holder 1 pce. flow rate: 1.2 ml/min 1233 Guard Column 4 pcs. 2130 Analytical Column with test chromatogram 1 pce. Switching valve: 6-port/3-channel switching 2131 SPE-Column 1 pce. valve (order no. FK1102) FK5810 PEEK capillary connector 1 pce. FK5820 Stainless steel prefilter holder 1 pce. Injection volume: 50 μl FK7400 Inline-Filter (stainless steel sieve, free of dead volume) 1 pce. Injection interval: 20 min Fluorescence Accessories: FK1102 Switching valve, Sykam (6-port/3-channel incl. electr. drive, PEEK) 1 pce. detector: 275 nm (exc.), 330 nm (em.) FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. HPLC-Thermostat: 30 °C FK7330 Endfittings 2 pcs. FK7340 Sealings and sieves 4 pcs. each ➜ on-line sample preparation FK7350 Endstoppers 2 pcs. Sample Pretreatment ® Addition of IS: ClinChek Controls: 2180 Urine Control (FD), lyophil., Level I 10 x 5 ml 2181 Urine Control (FD), lyophil., Level II 10 x 5 ml Add 20 μl Internal Standard IS/ml urine ➜ Robust chromatography 2182 Urine Control (FD), lyophil., Level I, II 2 x 5 x 5 ml ➜ centrifuge with fluorescence detection on-line Analysis:

Inject 50 μl

NE: Norepinephrine E: Epinephrine D: Dopamine

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Metanephrines, i.e. metanephrine (M), normetane - Biogenic Amines ClinChek® Urine Control, Level I ClinChek® Urine Control, Level II phrine (NM), and 3-methoxytyramine (MT), are the Diagnostics primary meta bolites of the catecholamines. Similar 100 100

to the catecholamines, the determination of the meta - 5.25 Metanephrines 75 75 6.48 nephrines is used to detect or rule out tumors of the 50 50

sympathoadrenal system. For this purpose, this 5.26 9.42

in Urine 9.43

25 25 15.03 6.47

test kit of RECIPE features particular user friend- 15.03

lyness within sample preparation. For a safe and Intensity (mV) 0 Intensity (mV) 0 convenient check-up of the pH-value prior to sample Test Data -25 -25 0 2 4 6 8 10 12 14 16 0 2 4 6 8 10 12 14 16 extraction, a special diluting solution with colour Linearity: 8 - 10000 μg/l

indicator is available. The distinct colouring of the Recovery: 60 % Retention Time (min) Retention Time (min) indicator assures that the analyte extraction is per- LOD / LLOQ: 5 μg/l / 8 μg/l Precision Normetanephrine: 5.26 min, Metanephrine: 6.47 min, Normetanephrine: 5.25 min, Metanephrine: 6.48 min, formed under appropriate pH conditions (pH > 6). IS: 9.43 min, 3-Methoxytyramine: 15.03 min IS: 9.42 min, 3-Methoxytyramine: 15.03 min Intraassay: 1.7 % (NM), 3.0 % (M), 2.5 % (MT) Also available: Test kits for automated sample pre- Interassay: 1.8 % (NM), 2.9 % (M), 1.9 % (MT) paration (see pages 28 - 29). Ordering Information Order No. Description Quantity HPLC Parameters Isocratic Pump: flow rate: 1.0 ml/min 4000 ClinRep® Complete Kit for Metanephrines in Urine for 100 assays 1 pce.

Injection vol. / int.: 20 μl / 17 min Kit components (order no. 4000): EC-Detector: pot.: 650 mV, sen.: 50 nA 4010 Mobile Phase 1000 ml 4011 Standard Solution 10 ml HPLC-Thermostat: 30 °C 4012 Internal Standard IS 3 ml 4013 Urine Calibrator, lyophil. 5 x 8 ml Sample Preparation 4020 Sample Preparation Columns 2 x 4020 (2 x 50 pcs.) 4022 Diluting Solution D 400 ml Hydrolysis: 4023 Washing Solution W 400 ml 4024 Eluting Reagent E 2 x 4024 (2 x 250 ml) 1 ml urine 20 μl Internal Standard IS 4025 Stabilising Reagent S 100 ml Manual 1 pce. ➜ 1. adjust pH to 0.5 - 1.0 2. incubate (30 min, 90 - 100 °C) Quick Reference 1 pce. pH adjustment: Start Accessories: 4030 Analytical Column with test chromatogram 1 pce. Add 4 ml Diluting Solution D (contains colour indicator) Accessories: check, if the sample ➜ if necessary, add FK4000 Column Rack (for 20 columns) 1 pce. is yellow (pH > 6) 1 M NaOH dropwise FK6300 Reagent tube (100 x 16 mm) with screw cap and o-ring, PP, autoclavable up to 121 °C 50 pcs.

pH = 4.5 pH = 5.0 pH = 5.5 pH = 6.5 pH = 7.0 pH = 7.5 ClinChek® Controls: + NaOH ➜ 8820 Urine Control, lyophil., Level I 10 x 8 ml 8821 Urine Control, lyophil., Level II 10 x 8 ml pH = 6.0 8822 Urine Control, lyophil., Level I, II 2 x 5 x 8 ml pH < 6.0 pH > 6.0 ➜ Safe and convenient too acidic ok ➜ pH-adjustment Extraction: Apply the whole sample on the sample preparation column

➜ wash (HPLC water and ➜ Robust chromatography Elution: Washing Solution W) Elute with 5 ml Eluting Reagent E (receiver vial: 1 ml Stabilising Reagent S) ➜ collect the eluate ➜ Low cost per test HPLC Analysis:

Inject 20 μl

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Metanephrines are important parameters for the Biogenic Amines Ordering Information diagnosis of tumors of the sympathoadrenal Order No. Description Quantity Diagnostics

® system. In addition to the ClinRep Complete Kit 4100 ClinRep® Complete Kit for Metanephrines in Urine 1 pce. with manual sample preparation (order no. 4000, Metanephrines in Urine with Gilson® ASPEC™ XL see pages 26 - 27) RECIPE offers two ClinRep® for 100 assays ® Complete Kits for automated sample preparation – with Gilson ASPEC™ XL Kit components (order no. 4100): with robotic systems from Gilson® and HTA. Kits for 4010 Mobile Phase 1000 ml – with HTA, Model HT400E 4011 Standard Solution 10 ml 100 and 500 assays are available for each system. 4012 Internal Standard IS 3 ml 4013 Urine Calibrator, lyophil. 5 x 8 ml 4120 Sample Preparation Columns 2 x 4120 (2 x 50 pcs.) Test Data 4022 Diluting Solution D 400 ml 4023 Washing Solution W 400 ml Test data are available on request 4124 Eluting Reagent E 250 ml 4125 Stabilising Reagent S 80 ml HPLC Parameters Manual 1 pce. Quick Reference 1 pce. Identical with order no. 4000, see pages 26 - 27 4200 ClinRep® Complete Kit for Metanephrines in Urine 1 pce. with Gilson® ASPEC™ XL Sample Preparation* for 500 assays Manual sample pretreatment Hydrolysis: Kit components (order no. 4200): 5-fold amount of kit components with order no. 4100 (4010, 4011, ..., 4125) 5 x 4100 1 ml urine 20 μl Internal Standard IS 4300 ClinRep® Complete Kit for Metanephrines in Urine 1 pce.

➜ with HTA, Model HT400E 1. adjust pH to 0.5 - 1.0 2. incubate (30 min, 90 - 100 °C) for 100 assays pH adjustment: Kit components (order no. 4300): Add 4 ml Diluting Solution D (contains colour indicator) 4010 Mobile Phase 1000 ml 4011 Standard Solution 10 ml

check, if the sample ➜ if necessary, add 4012 Internal Standard IS 3 ml is yellow (pH > 6) 1 M NaOH dropwise 4013 Urine Calibrator, lyophil. 5 x 8 ml 4320 Sample Preparation Columns 2 x 4320 (2 x 50 pcs.) pH = 4.5 pH = 5.0 pH = 5.5 pH = 6.5 pH = 7.0 pH = 7.5 4022 Diluting Solution D 400 ml

+ NaOH 4323 Washing Solution W 500 ml ➜ 4124 Eluting Reagent E 250 ml 4125 Stabilising Reagent S 80 ml pH = 6.0 FK6401 Sample vials, clear glass, 4ml 2 x FK6401 (2 x 100 pcs.) pH < 6.0 pH > 6.0 too acidic ok Manual 1 pce. Quick Reference 1 pce. Automated sample preparation with Gilson® ASPEC™ XL 4400 ClinRep® Complete Kit for Metanephrines in Urine 1 pce. Extraction: with HTA, Model HT400E for 500 assays Apply 2.5 ml sample to the sample preparation column

➜ Kit components (order no. 4400): wash (HPLC water and 5-fold amount of kit components with order no. 4300 (4010, 4011, ..., FK6401) 5 x 4300 ➜ Automated sample Elution: Washing Solution W) preparation Elute with 2.5 ml Eluting Reagent E Start Accessories: (receiver vial: 800 μl Stabilising Reagent S) 4030 Analytical Column with test chromatogram 1 pce. ➜ collect the eluate Accessories: HPLC Analysis: FK6300 Reagent tubes (100 x 16 mm) with screw cap and o-ring, PP, autoclavable up to 121 °C 50 pcs. ➜ Test kits available for Inject 20 μl 100 or 500 assays ClinChek® Controls: * The indicated sample/reagent volumes are exemplified for 8820 Urine Control, lyophil., Level I 10 x 8 ml 8821 Urine Control, lyophil., Level II 10 x 8 ml the ASPEC™ XL. The corresponding data for the HT400E 8822 Urine Control, lyophil., Level I, II 2 x 5 x 8 ml are available on request.

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Serotonin is a neurotransmitter in the central ner- Biogenic Amines ClinChek® Plasma Control, Level I ClinChek® Plasma Control, Level II vous system. Serotonin deficiencies are connected Diagnostics with disorders such as depression, schizophrenia, 1000 1000 and Parkinson's disease. Moreover, serotonin is 7.13 Serotonin in Plasma 7.13

produced in excess by carcinoid tumors. Here, the 5.56 500 500 determination of serotonin, together with its meta- 5.56 bolite 5-HIAA (see pages 34 - 35), is used to con- Test Data

Intensity (mV) 0 Intensity (mV) 0 firm or rule out the tumor. The RECIPE test kit allows Linearity: 1 - 1000 μg/l for a quick and sensitive determination of serotonin -250 -250 Recovery: 80 - 90 % 0246 8 10 0246 8 10 from platelet-rich plasma, platelet-poor plasma, and LOD: 0.5 μg/l serum. For the determination from urine an addi- LLOQ: 1 μg/l Retention Time (min) Retention Time (min) tional test kit is available (see pages 32 - 33). Intraassay precision: 3 % Serotonin: 5.56 min, IS: 7.13 min Serotonin: 5.56 min, IS: 7.13 min Interassay precision: 4 %

Ordering Information HPLC Parameters Order No. Description Quantity Pump: isocratic pump, ® flow rate: 1.0 ml/min 6000 ClinRep Complete Kit for Serotonin in Plasma for 100 assays 1 pce.

Injection volume: 20 μl Kit components (order no. 6000): Injection interval: 10 min 6710 Mobile Phase 1000 ml 6711 Standard Solution, lyophil. 5 x 2 ml EC-Detector: potential: 450 mV, 6712 Internal Standard IS, lyophil. 5 x 1 ml sensitivity: 20 nA 6013 Plasma Calibrator, lyophil. 5 ml HPLC-Thermostat: 30 °C 6020 Sample Preparation Vials 100 pcs. 6021 Precipitant P 22 ml Manual 1 pce. Sample Preparation Quick Reference 1 pce.

Precipitation: Start Accessories: 6030 Analytical Column with test chromatogram 1 pce. 200 μl plasma 10 μl Internal Standard IS ClinChek® Controls: ➜ 1. add 200 μl Precipitant P 2. centrifuge 8810 Plasma Control, lyophil., Level I 10 x 5 ml 8811 Plasma Control, lyophil., Level II 10 x 5 ml HPLC Analysis: 8809 Plasma Control, lyophil., Level I, II 2 x 5 x 5 ml

Inject 20 μl

➜ Quick sample preparation

➜ Injection interval: 10 min

➜ High analytical sensitivity

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Serotonin is an important neurotransmitter. The Biogenic Amines ClinChek® Urine Control, Level I ClinChek® Urine Control, Level II main metabolite of serotonin is 5-hydroxyindole Diagnostics acetic acid (5-HIAA) which is excreted with urine. 200 200 4.11 Patients with carcinoid tumors usually show Serotonin in Urine increased levels of serotonin in plasma and urine 132 132 5.31

as well as of 5-HIAA in urine (see pages 34 - 35). 5.31

66 4.13 66 As some tumors show a decreased serotonin turn- Test Data over (e.g. AADC-deficient tumors), low 5-HIAA levels Linearity: 5 - 1000 μg/l Intensity (mV) Intensity (mV) must be verified by the determination of serotonin. 0 0 Recovery: 70 - 85 % -22 -22 The test kit of RECIPE provides a highly selective LOD: 3 μg/l 02468 10 02468 10 sample preparation and guarantees a reliable LLOQ: 5 μg/l Retention Time (min) Retention Time (min) chromatography. Intraassay precision: 3 % Serotonin: 4.13 min, IS: 5.31 min Serotonin: 4.11 min, IS: 5.31 min Interassay precision: 4 %

Ordering Information HPLC Parameters Order No. Description Quantity Pump: isocratic pump, ® flow rate: 1.0 ml/min 7000 ClinRep Complete Kit for Serotonin in Urine for 100 assays 1 pce.

Injection volume: 20 μl Kit components (order no. 7000): Injection interval: 10 min 6710 Mobile Phase 1000 ml 6711 Standard Solution, lyophil. 5 x 2 ml EC-Detector: potential: 450 mV, 6712 Internal Standard IS, lyophil. 5 x 1 ml sensitivity: 50 nA 7013 Urine Calibrator, lyophil. 5 x 8 ml HPLC-Thermostat: 30 °C 7020 Sample Preparation Columns 2 x 7020 (2 x 50 pcs.) 7021 Stabilising Reagent S 2 x 7021 (2 x 200 ml) 7022 Washing Solution W 200 ml Sample Preparation 7023 Eluting Reagent E 500 ml Manual 1 pce. Dilution: Quick Reference 1 pce. 4 ml Stabilising 50 μl Internal 2 ml urine Reagent S Standard IS Start Accessories: 7030 Analytical Column with test chromatogram 1 pce. ➜ adjust pH to 4.5 - 6.5 Extraction: Accessories: FK4000 Column Rack (for 20 columns) 1 pce. Apply the whole sample on the sample preparation column ClinChek® Controls: ➜ wash (HPLC water and 8820 Urine Control, lyophil., Level I 10 x 8 ml Washing Solution W) 8821 Urine Control, lyophil., Level II 10 x 8 ml Elution: 8822 Urine Control, lyophil., Level I, II 2 x 5 x 8 ml

Apply 5 ml Eluting Reagent E ➜ collect the eluate ➜ Highly selective sample HPLC Analysis: clean up Inject 20 μl

➜ Reliable chromatography

➜ Injection interval: 10 min

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Vanillylmandelic acid (VMA) and homovanillic acid Biogenic Amines ClinChek® Urine Control, Level I ClinChek® Urine Control, Level II (HVA) are end-products of the catecholamine meta - Diagnostics bolism. The determination of VMA and HVA in urine 500 500 serves as a screening test for neuroblastoma, one of 400 400 VMA, HVA and 5-HIAA 11.77 the most common solid tumors in early childhood. 300 300 5-hydroxyindoleacetic acid (5-HIAA) is a metabolite in Urine 200 200

of serotonin and is used for the diagnosis of carci- 7.96 3.62 5.50

100 11.80 100 5.46 Intensity (mV) Intensity (mV)

® 7.99 noid tumors (see pages 30 - 33). This ClinRep 3.67 Complete Kit from RECIPE allows a reliable deter - Test Data 0 0 mination of VMA, HVA and 5-HIAA in only 15 min Linearity: VMA: 0.6 - 100 mg/l 0 2 4 6 8 10 12 14 0 2 4 6 8 10 12 14

time for analysis. HVA: 0.3 - 100 mg/l Retention Time (min) Retention Time (min) Also available: Complete kits for automated sam- 5-HIAA: 0.2 - 50 mg/l Recovery: 75 - 90 % VMA: 3.67 min, IS: 5.50 min, HVA: 7.99 min, VMA: 3.62 min, IS: 5.46 min, HVA: 7.96 min, ple preparation (see pages 36 - 37). 5-HIAA: 11.80 min 5-HIAA: 11.77 min LOD: VMA: 0.2 mg/l HVA: 0.1 mg/l Ordering Information 5-HIAA: 0.1 mg/l Order No. Description Quantity LLOQ: VMA: 0.6 mg/l HVA: 0.3 mg/l 3000 ClinRep® Complete Kit for VMA, HVA, 5-HIAA in Urine for 100 assays 1 pce.

5-HIAA: 0.2 mg/l Kit components (order no. 3000): Precision 3010 Mobile Phase 1000 ml 3011 Standard Solution, lyophil. 5 x 1 ml Intraassay: 2.6 % (VMA), 2.5 % (HVA), 3012 Internal Standard IS, lyophil. 100 ml 3.0 % (5-HIAA) 3013 Urine Calibrator, lyophil. 5 x 5 ml Interassay: 3.7 % (VMA), 3.8 % (HVA), 3020 Sample Preparation Columns 2 x 3020 (2 x 50 pcs.) 3021 Ammonia Solution A 100 ml 3.6 % (5-HIAA) 3022 Boric Acid Solution B 2 x 3022 (2 x 300 ml) 3023 Eluting Reagent E 2 x 3023 (2 x 100 ml) Manual 1 pce. HPLC Parameters Quick Reference 1 pce. Isocratic Pump: flow rate: 0.9 ml/min Injection vol. / int.: 20 μl / 15 min Start Accessories: 3030 Analytical Column with test chromatogram 1 pce. EC-Detector: pot.: 800 mV, sen.: 50 nA HPLC-Thermostat: 30 °C ClinChek® Controls: 8820 Urine Control, lyophil., Level I 10 x 8 ml 8821 Urine Control, lyophil., Level II 10 x 8 ml Sample Preparation 8822 Urine Control, lyophil., Level I, II 2 x 5 x 8 ml Addition of IS:

50 μl urine 1 ml Internal Standard IS ➜

Extraction: ➜ Highly selective sample preparation Apply the whole sample on the sample preparation column ➜ 1. wash with 1 ml Ammonia 2. fill up with Boric Acid B Solution A Elution:

➜ Injection interval: 15 min Apply 2 ml Eluting Reagent E ➜ collect the eluate HPLC Analysis:

➜ Reliable test procedure Inject 20 μl

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VMA, HVA and 5-HIAA are important parameters Biogenic Amines Ordering Information for the diagnosis of neuroblastoma and carcinoid Order No. Description Quantity Diagnostics

® tumors. In addition to the ClinRep Complete Kit 3100 ClinRep® Complete Kit for VMA, HVA, 5-HIAA in Urine 1 pce. with manual sample preparation (order no. 3000, VMA, HVA and 5-HIAA with Gilson® ASPEC™ XL see pages 34 - 35) RECIPE offers two ClinRep® for 100 assays Complete Kits for automated sample preparation in Urine Kit components (order no. 3100): with robotic systems from Gilson® and HTA. Kits for 3010 Mobile Phase 1000 ml – with Gilson® ASPEC™ XL 3011 Standard Solution, lyophil. 5 x 1 ml 100 and 500 assays are available for each system. 3012 Internal Standard IS 100 ml 3013 Urine Calibrator, lyophil. 5 x 5 ml – with HTA, Model HT400E 3120 Sample Preparation Columns 2 x 3120 (2 x 50 pcs.) 3021 Ammonia Solution A 100 ml 3022 Boric Acid Solution B 2 x 3022 (2 x 300 ml) 3023 Eluting Reagent E 2 x 3023 (2 x 100 ml) Test Data Manual 1 pce. Test data are available on request Quick Reference 1 pce.

3200 ClinRep® Complete Kit for VMA, HVA, 5-HIAA in Urine 1 pce. HPLC Parameters with Gilson® ASPEC™ XL Identical with order no. 3000, see pages 34 - 35 for 500 assays

Kit components (order no. 3200): Sample Preparation* 5-fold amount of kit components with order no. 3100 (3010, 3011, ..., 3023) 5 x 3100 Automated sample preparation 3300 ClinRep® Complete Kit for VMA, HVA, 5-HIAA in Urine 1 pce. with Gilson® ASPEC™ XL with HTA, Model HT400E Addition of IS: for 100 assays

50 μl urine 1 ml Internal Standard IS Kit components (order no. 3300): 3010 Mobile Phase 1000 ml ➜ 3011 Standard Solution, lyophil. 5 x 1 ml Extraction: 3012 Internal Standard IS 100 ml 3013 Urine Calibrator, lyophil. 5 x 5 ml Apply 1 ml sample on the sample preparation column 3320 Sample Preparation Columns 2 x 3320 (2 x 50 pcs.) 3021 Ammonia Solution A 100 ml ➜ 1. wash with 1 ml Ammonia 2. wash with 2.5 ml Boric 3022 Boric Acid Solution B 2 x 3022 (2 x 300 ml) Solution A Acid B 3023 Eluting Reagent E 2 x 3023 (2 x 100 ml) Elution: FK6401 Sample vials, clear glass, 4ml 2 x FK6401 (2 x 100 pcs.) FK6402 Sample vial without cap, PP, 1.5 ml 100 pcs. Apply 2 ml Eluting Reagent E Manual 1 pce. Quick Reference 1 pce. ➜

HPLC Analysis: 3400 ClinRep® Complete Kit for VMA, HVA, 5-HIAA in Urine 1 pce. with HTA, Model HT400E Inject 20 μl for 500 assays

Kit components (order no. 3400): * The indicated sample/reagent volumes are exemplified for 5-fold amount of kit components with order no. 3300 (3010, 3011, ..., FK6402) 5 x 3300 ➜ Automated sample the ASPEC™ XL. The corresponding data for the HT400E are available on request. Start Accessories: preparation 3030 Analytical Column with test chromatogram 1 pce.

ClinChek® Controls: 8820 Urine Control, lyophil., Level I 10 x 8 ml 8821 Urine Control, lyophil., Level II 10 x 8 ml ➜ Test kits available for 8822 Urine Control, lyophil., Level I, II 2 x 5 x 8 ml 100 or 500 assays

➜ Injection interval: 15 min

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Diabetes mellitus is a chronic disease which is asso- Diabetes, Hemoglobin Testing ClinChek® Hemolysate Control, Level I ClinChek® Hemolysate Control, Level II Diagnostics ciated with abnormally high blood glucose levels. The 10% 10% 4.0 4.0 9 determination of HbA1c is an important diagnostic 9 2.7 8 tool for monitoring the efficiency of dietary control 8 Hemoglobin A1c 7 7 and therapy during treatment of diabetes mellitus. 6 6 2.8 Due to the excellent specificity and reproducibility, (HbA1c) in Whole 5 5 4 HPLC is still considered as the ”gold standard” 4 Intensity TM 3 Intensity 3

method for the adjustment of the blood glucose con - Blood (for Diamat 2 1.6 1.6 2 1.1 2.1 1.1 centration in diabetes patients. The HbA1c values, 1 1 and Modular HPLC) 0 0 obtained with this method, are in accordance with 012345 012345

the value level of the DCCT and are traceable to Retention Time (min) Retention Time (min) the IFCC reference system. The kit can be applied Test Data HbA1a: 1.1 min, HbA1b: 1.6 min, HbF: 2.1 min, HbA1a: 1.1 min, HbA1b: 1.6 min, HbA1c: 2.7 min, TM to the analyser Diamat or any conventional mo du - Linearity: The test is linear over the whole range of HbA1c: 2.8 min, HbA0: 4.0 min HbA0: 4.0 min lar HPLC system. phy sio lo gi cally occurring HbA1c values (approx. 3 - 16 % HbA1c). Ordering Information Intraassay precision: 1 - 2 % Order No. Description Quantity Interassay precision: 2 - 3 % 11000 ClinRep® Complete Kit for Hb A1c in Whole Blood for 1000 assays 1 pce.

Dependence on the amount of total hemoglobin: Components of the Complete Kit (order no. 11000): 11001 ClinRep® Reagent Kit 1 pce. The HbA1c value is independent on the amount of 11011 Reference Standard 10 x 5 ml total hemoglobin in a range from 6 - 24 g/dl total 11030 Analytical Column with test chromatogram 1 pce. hemoglobin. Manual 1 pce. Quick Reference 1 pce.

HPLC Parameters Components of the Reagent Kit (order no. 11001): 11007 Buffer 1 2 x 11007 (2 x 2400 ml) TM for Modular HPLC Systems / for Diamat 11008 Buffer 2 2400 ml Pump: Ternary Gradient Pump / 11009 Buffer 3 2 x 11009 (2 x 2100 ml) Ternary Gradient Pump 11013 Hemolysis Reagent H 1300 ml 11014 Washing Solution W 2100 ml Flow rate: 1.5 ml/min / 1.1, 1.5 or 1.8 ml/min Injection volume: 20 μl / 20 μl Refill Service: 11031 Analytical Column (refill) with test chromatogram 1 pce. Injection interval: 5 min / 8-, 5- or 3 min programme (original column needs to be returned) UV/VIS-Detector: 415 nm / 415 nm HPLC-Thermostat: 23 °C / 23 °C Accessories: 11020 ClinRep® Sample Preparation Kit for Capillary Blood (for 50 assays) 1 set containing: Sample Preparation 50 Sample vials with 1 ml hemolysis reagent each, 1 Capillary holder 1 Capillary dispenser with 50 heparinised capillaries à 5 μl A: Venous Blood 11021 50 Sample vials with 1 ml of hemolysis reagent each 20 sets Hemolysis: 11022 Capillary dispenser, cont. 50 heparinised capillaries à 5 μl 20 pcs. ➜ Reliable and cost-efficient 11023 Capillary holder 20 pcs. 5 μl venous blood 1.25 ml Hemolysis Reagent H 11024 Sample vials 1.5 ml without cap 1000 pcs. analysis 11026 Hemolysis Reagent esp. for capillary blood sampling (heavy metal free) 2000 ml ➜ 11027 Sample vials 1.5 ml with purple cap 1000 pcs. incubate (30 min, 37 °C) HPLC Analysis: 11038 Printerpaper 10 rolls FK5810 PEEK tubing (connection of prefilter and column) 1 pce. Inject 20 μl FK5820 Stainless steel prefilter holder 1 pce. ➜ ”Gold standard” for HbA1c FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. B: Capillary Blood ClinChek® Controls: analysis Hemolysis: 11080 Hemolysate Control, Level I, ready for use 10 x 5 ml 11081 Hemolysate Control, Level II, ready for use 10 x 5 ml 5 μl capillary blood vial with Hemolysis Reagent H 11082 Hemolysate Control, Level I, II, ready for use 2 x 5 x 5 ml ➜ ➜ Column lifetime: incubate (24 h, ambient temperature) > 1000 analyses HPLC Analysis: Inject 20 μl DIAMATTM is a registered trademark of BioRad

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This RECIPE HbA1c test kit is designed for the Diabetes, Hemoglobin Testing ClinChek® Hemolysate Control, Level I ClinChek® Hemolysate Control, Level II appli cation with the analyser VariantTM. However, the Diagnostics 20% 20% 1.61 kit can also be used with any conventional modular 1.61 HPLC system. Hemoglobin A1c 15 15 (HbA1c) in Whole 10 10 1.03 1.07 Intensity TM Intensity Blood (for Variant 5 5 0.55 0.55 0.75 0.39 0.40 0.76 and Modular HPLC) 0 0 0123 0123

Retention Time (min) Retention Time (min) Test Data HbA1a: 0.40 min, HbA1b: 0.55 min, HbF: 0.75 min, HbA1a: 0.39 min, HbA1b: 0.55 min, HbF: 0.76 min, Linearity: The test is linear over the whole range of HbA1c: 1.07 min, HbA0: 1.61 min HbA1c: 1.03 min, HbA0: 1.61 min phy sio lo gi cally occurring HbA1c values (approx. 3 - 16 % HbA1c). Ordering Information Intraassay precision: 1 - 2 % Order No. Description Quantity Interassay precision: 2 - 3 % 11100 ClinRep® Complete Kit for Hb A1c in Whole Blood for 1000 assays 1 pce.

Dependence on the amount of total hemoglobin: Components of the Complete Kit (order no. 11100): 11101 ClinRep® Reagent Kit 1 pce. The HbA1c value is independent on the amount of 11011 Reference Standard 10 x 5 ml total hemoglobin in a range from 6 - 24 g/dl total 11130 Analytical Column with test chromatogram 1 pce. hemoglobin. Manual 1 pce. Quick Reference 1 pce.

HPLC Parameters Components of the Reagent Kit (order no. 11101): 11107 Buffer 1 2 x 11107 (2 x 2400 ml) Pump: binary gradient pump 11108 Buffer 2 2 x 11108 (2 x 2400 ml) Flow rate: 2.0 ml/min 11013 Hemolysis Reagent H 1300 ml Injection volume: 20 μl 11014 Washing Solution W 2100 ml

Injection interval: 3 min Accessories: UV/VIS-Detector: 415 nm 11020 ClinRep® Sample Preparation Kit for Capillary Blood (for 50 assays) 1 set containing: HPLC-Thermostat: 23 °C 50 Sample vials with 1 ml hemolysis reagent each, 1 Capillary holder 1 Capillary dispenser with 50 heparinised capillaries à 5 μl Sample Preparation 11021 50 Sample vials with 1 ml of hemolysis reagent each 20 sets 11022 Capillary dispenser, cont. 50 heparinised capillaries à 5 μl 20 pcs. A: Venous Blood 11023 Capillary holder 20 pcs. Hemolysis: 11024 Sample vials 1.5 ml without cap 1000 pcs. 11026 Hemolysis Reagent esp. for capillary blood sampling (heavy metal free) 2000 ml 5 μl venous blood 1.25 ml Hemolysis Reagent H 11027 Sample vials 1.5 ml with purple cap 1000 pcs. 11138 Printerpaper 10 rolls

➜ ➜ FK5810 PEEK tubing (connection of prefilter and column) 1 pce. Reliable and cost-efficient incubate (30 min, 37 °C) HPLC Analysis: FK5820 Stainless steel prefilter holder 1 pce. analysis FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. Inject 20 μl ClinChek® Controls: 11080 Hemolysate Control, Level I, ready for use 10 x 5 ml B: Capillary Blood 11081 Hemolysate Control, Level II, ready for use 10 x 5 ml ➜ ”Gold standard” for HbA1c Hemolysis: 11082 Hemolysate Control, Level I, II, ready for use 2 x 5 x 5 ml analysis 5 μl capillary blood vial with Hemolysis Reagent H ➜ incubate (24 h, ambient temperature) HPLC Analysis: ➜ Column lifetime: Inject 20 μl > 1000 analyses VARIANTTM is a registerd trademark of BioRad

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Defects in genes, which are responsible for the syn - Diabetes, Hemoglobin Testing ClinCal® Hemolysate Calibrator (HbF/A2) ClinCheck® Hemolysate Control (HbF/A2/S), Level I the sis of the hemoglobin molecule, result in a group Diagnostics 50 50 3.72 5.52 of hereditary diseases termed as ”hemo glo bino - 3.74 pathies”. Depending on the molecular defect, hemo - Hemoglobin Variants 40 40 globinopathies may be classified in ”structural he - β 30 30 mo glo bin variants” and in ”thalassemias”. This test and -Thalassemia 20 20 4.71 4.71

kit allows for a reliable separation and identification 2.03

10 1.59 10 1.58 2.01 of the common and clinically significant hemoglobin Screening in Intensity (mV) Intensity (mV) variants. For ß-thalassemia screening the kit ensures Whole Blood 0 0 an exact quan tification of HbF and HbA2. A ready- 0 1 2 3 4 5 6 7 0 1 2 3 4 5 6 7

to-use test solution (containing: HbA1c, HbF, HbA0, Retention Time (min) Retention Time (min) HbE, HbA2, HbD, HbS, HbC), a hemolysate calibra - Test Data tor (containing: HbF, HbA2) as well as he mo lysate HbA1c: 1.59 min, HbF: 2.03 min, HbA0: 3.74 min, HbA1c: 1.58 min, HbF: 2.01 min, HbA0: 3.72 min, Intraassay precision: 1.0 - 3.3 % (HbF) HbA2: 4.71 min HbA2: 4.71, HbS: 5.52 min controls in two levels of concentration are available 0.6 - 3.6 % (HbA2) for quality assurance. Interassay precision: 2.1 - 2.8 % (HbF) Ordering Information 0.7 - 2.4 (HbA2) Order No. Description Quantity

13100 ClinRep® Complete Kit for Hemoglobin Variants and ß-Thalassemia Screening 1 pce. Dependence on total hemoglobin: in Whole Blood for 500 assays The HbF and HbA2 values are independent on the Components of the Complete Kit (order no. 13100): amount of total hemoglobin in a range from 6 - 24 13101 ClinRep® Reagent Kit 1 pce. g/dl total hemoglobin. 13113 Hemolysate Calibrator HbF/A2, ready for use 5 x 3 ml 13130 Analytical Column with test chromatogram 1 pce. Manual 1 pce. HPLC Parameters Quick Reference 1 pce. Pump: binary gradient pump Components of the Reagent Kit (order no. 13101): Flow rate: 1.2 ml/min 13107 Buffer 1 2500 ml Injection volume: 20 μl 13108 Buffer 2 2500 ml Injection interval: 8 min 13109 Washing Solution W 2000 ml 13121 Hemolysis Reagent H 500 ml UV/VIS-Detector: 415 nm HPLC-Thermostat: 23 °C Optional Components: 13114 Test Solution (HbA1c/F/A/E/A2/D/S/C), ready for use 5 x 3 ml

Sample Preparation Accessories: 11024 Sample vials 1.5 ml without cap 1000 pcs. Hemolysis: FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. 5 μl venous blood 1 ml Hemolysis Reagent H FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. ➜ incubate (10 min, ambient temp.) ClinChek® Controls: HPLC Analysis: 13182 Hemolysate Control HbF/A2, Level I, II, ready for use 2 x 5 x 3 ml 13183 Hemolysate Control HbF/A2/S, Level I, ready for use 5 x 3 ml ➜ Reliable separation Inject 20 μl and quantification of HbA2 and HbF

➜ Safe identification of HbS, HbC, HbE and HbD

➜ Test solution, calibrator and control materials available

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Several metabolic disorders result from an impaired Metabolic Diseases ClinChek® Plasma Control, Level I ClinChek® Plasma Control, Level II amino acid metabolism. Furthermore, some forms Diagnostics

of depression seem to be connected with alterations 2.18 3.85 9.80 40 40 of the metabolism of tyrosine and tryptophane, these Aromatic Amino Acids 30 30 being the precursors of the brain neurotransmitters

epinephrine, norepinephrine, dopamine, and sero- 20 2.18 20 in Plasma 9.76 tonin. The ClinRep® Complete Kit serves for the 3.84 7.11 10 10 7.14

analysis of the amino acids phenylalanine, tyrosine Intensity (mV) Intensity (mV) 0 0 and tryptophane and may be used for the monitoring Test Data of the blood plasma level within a dietary therapy. Linearity: 0.2 - 50 mg/dl 02468 1012 02468 1012

Recovery: 90 - 100 % Retention Time (min) Retention Time (min) Important notice: Lower detection limit: 0.1 mg/dl The kit is not intended for use in neonatal screening pro- Lower determination limit: 0.2 mg/dl Tyrosine: 2.18 min, Phenylalanine: 3.84 min, IS: 7.11 min, Tyrosine: 2.18 min, Phenylalanine: 3.85 min, IS: 7.14 min, grammes and especially not for PKU diagnosis. For this dia- Tryptophane: 9.76 min Tryptophane: 9.80 min gnostic purpose two ClinMass® LC-MS/MS Complete Kits are Intraassay precision: Plasma: 2.9 %, provided (see pages 154 - 157). Interassay precision: Plasma: 4.5 %, Ordering Information Order No. Description Quantity HPLC Parameters Pump: isocratic pump, 10000 ClinRep® Complete Kit for Aromatic Amino Acids in Plasma for 100 assays 1 pce.

flow rate: 1.0 ml/min Kit Components (order no.: 10000) Injection volume: 20 μl 10010 Mobile Phase 1000 ml 10011 Standard Solution 4 ml Injection interval: 12 min 10013 Plasma Calibrator, lyophil. 3 ml UV/VIS-Detector: 214 nm 10020 Precipitant P with Internal Standard (contained in vials for sample preparation) 2 x 10020 (50 x 0.5 ml) HPLC-Thermostat: 30 °C Manual 1 pce. Quick Reference 1 pce.

Sample Preparation Start Accessories: 10030 Analytical Column with test chromatogram 1 pce. Precipitation: FK7000 manu-CART® cartridgeholder, one time accessory 1 set Pipette 50 μl sample into a vial with order no. 10020 (contains Precipitant P and Internal Standard) Accessories:

➜ FK5810 PEEK tubing (connection of prefilter and column) 1 pce. 1. incubate (15 min, 4 °C) 2. centrifuge FK5820 Stainless steel prefilter holder 1 pce. HPLC Analysis: FK5821 Replacement filter for stainless steel prefilter holder 10 pcs.

ClinChek® Controls: Inject 20 μl of the supernatant 10080 Plasma Control, lyophil., Level I 10 x 3 ml 10081 Plasma Control, lyophil., Level II 10 x 3 ml 10082 Plasma Control, lyophil., Level I, II 2 x 5 x 3 ml

➜ Easy sample preparation

➜ High analytical sensitivity

➜ Reliable monitoring

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Homocysteine is an established marker to estimate Metabolic Diseases ClinChek® Plasma Control, Level I ClinChek® Plasma Control, Level II the risk towards atherosclerosis and coronary heart Diagnostics disease. An elevated plasma homocysteine level 400 400 (hyperhomocysteinemia), whether due to nutrient Homocysteine 300 300 deficiencies or by genetic defects, can be reduced 2.85 2.85 2.48 2.11 by intake of folic acid, vitamin B6 and B12. There - in Plasma 200 2.47 200 2.10 fore, the determination of homocysteine does not 3.31 100 100 Intensity (mV) Intensity (mV)

only serve for the risk assessment towards athero- 3.31

sclerotic affections but also to ensure the proper Test Data 0 0

combination and dosage of a nutrition supplement Linearity: 1 - 100 μmol/l 0 1 2 3 4 5 0 1 2 3 4 5

therapy. The RECIPE test kit allows for the simul- Recovery: 95 - 105 % Retention Time (min) Retention Time (min) taneous analysis of total homocysteine (tHcys) and LOD: 0.5 μmol/l LLOQ: 1 μmol/l Cysteine: 2.10 min, IS: 2.47 min, Cysteinylglycine: 2.85 min, Cysteine: 2.11 min, IS: 2.48 min, Cysteinylglycine: 2.85 min, total cysteine (tCys). Homocysteine: 3.31 min Homocysteine: 3.31 min Intraassay precision: 3.9 % Interassay precision: 5.8 % Ordering Information Order No. Description Quantity HPLC Parameters Pump: isocratic pump, flow rate: 23000 ClinRep® Complete Kit for Homocysteine in Plasma for 100 assays 1 pce.

1.0 ml/min Kit Components (order no. 23000): Injection volume: 20 μl 23010 Mobile Phase 1000 ml 23011 Standard Solution 3 ml Injection interval: 5 min 23012 Internal Standard IS 3 ml Fluorescence 23013 Plasma Calibrator, lyophil. 3 ml detector: 385 nm (exc.), 515 nm (em.) 23020 Sample Preparation Vials 100 pcs. 23021 Reagent A 3 ml HPLC-Thermostat: 30 °C 23022 Reagent B 10 ml 23023 Reagent C 10 ml 23024 Reagent D 5 ml Sample Preparation Manual 1 pce. Reduction: Quick Reference 1 pce.

25 μl Internal 100 μl plasma 25 μl Reagent A Start Accessories: Standard IS 23030 Analytical Column with test chromatogram 1 pce. ➜

Precipitation: Accessories: 23060 250 μl derivatisation vial with cap (PE) 50 pcs. 150 μl reduced sample 100 μl Reagent B FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce.

➜ FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. centrifuge Derivatisation: ClinChek® Controls: 50 μl supernatant 100 μl Reagent C 50 μl Reagent D 23080 Plasma Control, lyophil., Level I 10 x 3 ml 23081 Plasma Control, lyophil., Level II 10 x 3 ml

➜ ➜ 23082 Plasma Control, lyophil., Level I, II 2 x 5 x 3 ml Reliable sample incubate (60 min, 60 °C) HPLC Analysis: preparation (specific derivatisation reagent) Inject 20 μl

➜ Injection interval: 5 min

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Osteoporosis is a metabolic bone disease which is Metabolic Diseases ClinChek® Urine Control, Level I ClinChek® Urine Control, Level II characterised by an abnormally low bone density Diagnostics

and therefore is associated with an increased risk 9 9 of fracture. The bone degradation goes along with Hydroxyproline

an increased formation of the amino acid hydroxypro - 6 6 3.20 line, which is released into blood circulation and is in Urine 5.10 excreted with urine. The RECIPE test kit guaran tees 3 5.10 3 Intensity (mV) Intensity (mV) an accurate hydroxyproline measurement. Using a 3.20 special sample preparation, hydroxyproline is turned Test Data 0 0

into a derivative and can be quantified without inter - Linearity: 5 - 170 mg/l 0 1 2 3 4 5 6 0 1 2 3 4 5 6

ferences from other amino acids. Recovery: 90 - 100 % Retention Time (min) Retention Time (min) LOD: 3 mg/l LLOQ: 5 mg/l Hydroxyproline: 3.20 min, IS: 5.10 min Hydroxyproline: 3.20 min, IS: 5.10 min Intraassay precision: 3.5 % Interassay precision: 4.5 % Ordering Information Order No. Description Quantity

HPLC Parameters 16000 ClinRep® Complete Kit for Hydroxyproline in Urine for 100 assays 1 pce. Pump: binary gradient pump, Kit Components (order no 16000): flow rates: 1.2, 1.4 ml/min 16008 Mobile Phase A 1000 ml Injection volume: 20 μl 16009 Mobile Phase B 150 ml 16011 Standard Solution 5 ml Injection interval: 8 min 16012 Internal Standard IS 10 ml UV/VIS-Detector: 471 nm 16013 Urine Calibrator, lyophil. 5 x 8 ml HPLC-Thermostat: 60 °C 16020 Hydrolysis Tubes with caps 100 pcs. 16021 pH - Test Stripes 100 pcs. 16022 Reagent A 30 ml Sample Preparation 16023 Reagent B 80 ml 16024 Reagent C 80 ml Hydrolysis: 16025 Reagent D 2 x 16025 (2 x 50 mg) 100 μl Internal 16026 Reagent E 20 ml 1 ml urine 1 ml HCl Standard IS Manual 1 pce. Quick Reference 1 pce. ➜ incubate (16 h, 95 °C) Derivatisation: Start Accessories: 1. 100 μl sample + 300 μl Reagent A + 800 μl Reagent B / C 16030 Analytical Column with test chromatogram 1 pce. 2. 500 μl sample + 200 μl Reagent D 3. 150 μl sample + 200 μl Reagent E Accessories: FK5810 PEEK tubing (connection of prefilter and column) 1 pce. ➜➜ incubate (10 min, 70 °C) FK5820 Stainless steel prefilter holder 1 pce. Dilution: FK5821 Replacement filter for stainless steel prefilter holder 10 pcs.

Complete sample 500 μl Mobile Phase A ClinChek® Controls: 8820 Urine Control, lyophil., Level I 10 x 8 ml ➜ High analytical selectivity 8821 Urine Control, lyophil., Level II 10 x 8 ml HPLC Analysis: 8822 Urine Control, lyophil., Level I, II 2 x 5 x 8 ml

Inject 20 μl ➜ Injection interval: 8 min

➜ Reliable determination

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The porphyrin excretion profile is used for the dia- Metabolic Diseases ClinChek® Urine Control, Level I ClinChek® Urine Control, Level II gnosis of porphyrias. This ClinRep® Complete Kit Diagnostics allows for a separation (differentiation) of the uri - 30 100 11.37 nary porphyrins with high resolution (in different 12.67 Porphyrins 25 80 porphyrin-isomers!) and ensures an exact quantifi- 20 12.68 60 cation. For sample preparation, the samples simply Differentiated in Urine 15 8.86 10 40 5.16 have to be spiked with an internal standard and 11.39

5 20 8.86 9.55 Intensity (mV) Intensity (mV) ® 5.19 9.55 6.31 7.54 centrifuged. For porphyria screening ClinEasy 6.28

0 7.53 Photo metric Complete Kits are available for the de - Test Data 0 0 2 4 6 8 10 12 14 16 18 20 0 2 4 6 8 10 12 14 16 18 20 ter mination of the total porphyrins, 5-aminolevulinic Linearity: 1 - 5000 μg/l

acid and porphobilinogen (see pages 108 - 113). LOD: 0.5 μg/l Retention Time (min) Retention Time (min) LLOQ: 1 μg/l Intraassay precision: 2.3 % Uroporphyrin I: 5.19 min, Heptacarboxyporphyrin I: 6.31 min, Uroporphyrin I: 5.16 min, Heptacarboxyporphyrin I: 6.28 min, Hexacarboxyporphyrins (Iac and Iab Isomer): 7.54 min, Hexacarboxyporphyrins (Iac and Iab Isomer): 7.53 min, Interassay precision: 2.6 % Internal Standard IS: 8.86 min, Pentacarboxyporphyrin I: 9.55 min, Internal Standard IS: 8.86 min, Pentacarboxyporphyrin I: 9.55 min, Coproporphyrin I: 11.39 min, Coproporphyrin III: 12.68 min Coproporphyrin I: 11.37 min, Coproporphyrin III: 12.67 min HPLC Parameters Pump: binary gradient pump, Ordering Information flow rate: 0.7 ml/min Order No. Description Quantity

Injection volume: 20 μl 17000 ClinRep® Complete Kit for Porphyrins in Urine for 100 assays 1 pce. Injection interval: 20 min Fluorescence Kit Components (order no. 17000): 17008 Mobile Phase A 2 x 17008 (2 x 1000 ml) detector: 394 nm (exc.), 624 nm (em.) 17009 Mobile Phase B 800 ml HPLC-Thermostat: 30 °C 17011 Standard Solution 5 ml 17012 Internal Standard IS 5 ml 17013 Urine Calibrator, lyophil. 5 x 5 ml Sample Preparation 17020 Vials for Sample Pretreatment 100 pcs. Manual 1 pce. Addition of IS: Quick Reference 1 pce. 500 μl urine 50 μl (calibrator, control, patient) Internal Standard IS Start Accessories: 17030 Analytical Column with test chromatogram 1 pce. ➜ centrifuge 17032 Guard Column Holder incl. 1 Guard Column 1 pce. HPLC Analysis: 17033 Guard Column 5 pcs.

Inject 20 μl of the supernatant Accessories: FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. FK5821 Replacement filter for stainless steel prefilter holder 10 pcs.

ClinChek® Controls: 17080 Urine Control, lyophil., Level I 10 x 5 ml 17081 Urine Control, lyophil., Level II 10 x 5 ml ➜ High resolution of the 17082 Urine Control, lyophil., Level I, II 2 x 5 x 5 ml porphyrin profile

➜ No interferences

➜ High analytical sensitivity

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β-Carotene belongs to the group of the so-called Oxidative Stress ClinChek® Plasma Control, Level I ClinChek® Plasma Control, Level II carotenoids. These compounds are part of the anti - Diagnostics oxidant defense system within the human organism 0.015 0.015 3.55 3.55 and are protecting cells and tissues from oxidative β-Carotene damage (oxidative stress). All-trans-β-carotene is 0.010 0.010 8.43 the quantitatively most important carotenoid in our in Plasma / Serum diet, in human blood and tissues. The RECIPE 0.005 8.43 0.005

® Intensity (mV) Intensity (mV) 7.79 ClinRep Complete Kit for β-carotene provides a 7.81 9.23 9.76 9.23 9.76 unique chromatographical performance. Even the Test Data 0.000 0.000

cis-isomers of β-carotene (9-cis-β-carotene, 13-cis- On request 0101 2 3 4 5 6 7 8 9 0101 2 3 4 5 6 7 8 9

β-carotene) are base line separated. Prior to HPLC Retention Time (min) Retention Time (min) analysis a simple two-step sample preparation HPLC Parameters Pump: isocratic pump, IS: 3.55 min, α-Carotene: 7.79 min, all-trans-ß-Carotene: IS: 3.55 min, α-Carotene: 7.81 min, all-trans-ß-Carotene: (precipitaton, stabilisation) is required. 8.43 min, 9-cis-ß-Carotene: 9.23 min, 13-cis-ß-Carotene: 8.43 min, 9-cis-ß-Carotene: 9.23 min, 13-cis-ß-Carotene: flow rate: 1.1 ml/min 9.76 min 9.76 min Injection volume: 100 μl Injection interval: 10 min Ordering Information UV-Detector: 450 nm Order No. Description Quantity HPLC-Thermostat: 30 °C 30000 ClinRep® Complete Kit for ß-Carotene in Plasma / Serum 1 pce. for 100 assays Sample Preparation

Precipitation: Kit Components (order no. 30000): 30010 Mobile Phase 1000 ml 200 μl Precipitant P 100 μl Stabilising 30012 Precipitant P with Internal Standard 20 ml 100 μl sample (contains IS) Reagent S 30013 Plasma Calibrator, lyophil. 5 x 0.5 ml

➜ 30014 Test Solution, lyophil. 3 ml mix, centrifuge HPLC Analysis: 30020 Sample Preparation Vials 100 pcs. 30021 Stabilising Reagent S 10 ml Manual 1 pce. Inject 100 μl Quick Reference 1 pce.

Start Accessories: 30030 Analytical Column with test chromatogram 1 pce.

Accessories: FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. FK5821 Replacement filter for stainless steel prefilter holder 10 pcs.

ClinChek® Controls: 30080 Plasma Control, lyophil., Level I 10 x 2 ml 30081 Plasma Control, lyophil., Level II 10 x 2 ml 30082 Plasma Control, lyophil., Level I, II 2 x 5 x 2 ml ➜ Simple two-step sample preparation

➜ Excellent chromatographic performance (separation of cis isomers)

➜ Injection interval: 10 min

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Coenzyme Q10 (CoQ10) plays an outstanding role Oxidative Stress ClinChek® Plasma Control, Level I ClinChek® Plasma Control, Level II in the energy production within the cell metabolism. Diagnostics In addition, CoQ10 is an important antioxidant and 1,5 1,5 thus protects the cell from radical oxidation (oxida- Coenzyme Q10 tive stress). Lowered blood concentrations of CoQ10 1,0 1,0 11.49 7.32 seem to be connected with a number of affections, in Whole Blood / 7.34 mainly cardiovascular diseases. The RECIPE 0,5 0,5 11.54 Intensity (mV) ClinRep® Complete Kit allows for a reliable de ter - Plasma / Serum Intensity (mV) 0,0 0,0 mi nation of CoQ10 in whole blood, plasma, and serum. After a quick sample preparation, the analy - 0101 2 3 4 5 6 7 8 9 11 12 13 14 0101 2 3 4 5 6 7 8 9 11 12 13 14 Test Data tical chro ma tography is performed with an isocratic Retention Time (min) Retention Time (min) Linearity: 38.9 - 20000 μg/l HPLC system and UV detection. For quality assu- Recovery: 94 - 108 % IS: 7.34 min, CoQ10: 11.54 min IS: 7.32 min, CoQ10: 11.49 min rance reference materials (ClinTest® Test Solution, LOD: 19.5 μg/l ClinCal® Plasma Cali bra tor and ClinChek® Plasma LLOQ: 38.9 μg/l Ordering Information Controls) with excellent stability are available. Intraassay precision: 3.4 % Order No. Description Quantity Interassay precision: 5.0 % 31000 ClinRep® Complete Kit for Coenzyme Q10 in Whole Blood / Plasma / Serum 1 pce. for 100 assays HPLC Parameters Kit Components (order no. 31000): Pump: isocratic pump, flow rate: 31010 Mobile Phase 1000 ml 1.4 ml/min 31012 Internal Standard IS 40 ml 31013 Plasma Calibrator, lyophil. 5 x 2 ml Injection volume: 30 μl 31014 Test Solution 3 ml Injection interval: 14 min 31020 Sample Preparation Vials 100 pcs. UV-Detector: 275 nm 31021 Precipitant P 50 ml 31022 Oxidation Reagent O 5 ml HPLC-Thermostat: 30 °C Manual 1 pce. Quick Reference 1 pce. Sample Preparation Start Accessories: Precipitation: 31030 Analytical Column with test chromatogram 1 pce. 31032 Guard Column Holder incl. 1 Guard Column 1 pce. 500 μl Precipitant P Accessories:

➜ 31033 Guard Column 5 pcs. FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. 1. Add 400 μl sample FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. 2. Add 50 μl Oxidation Reagent O

➜ ClinChek® Controls: mix 31080 Plasma Control, lyophil., Level I 10 x 2 ml 31081 Plasma Control, lyophil., Level II 10 x 2 ml Add 400 μl Internal Standard IS 31082 Plasma Control, lyophil., Level I, II 2 x 5 x 2 ml ➜ Reliable sample ➜ mix, centrifuge preparation HPLC Analysis:

Inject 30 μl of the supernatant

➜ Reference materials with excellent stability available

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Malondialdehyde is formed by radical mediated lipid Oxidative Stress ClinChek® Plasma Control, Level I ClinChek® Plasma Control, Level II peroxidation (oxidative stress) and shows mutage - Diagnostics nic and cytotoxics effects by further reaction with 35 35 DNA. For this reason, malondialdehyde is considered 30 30 Malondialdehyde 25 25 a suitable biomarker for the determination of oxi - 20

20 2.75 da tive stress. The RECIPE ClinRep® Complete Kit 15 15

in Plasma / Serum 2.75 10 10 allows for the reliable quantification of malondial- 5 5 Intensity (mV) dehyde from plasma and serum. For quality assu- Intensity (mV) 0 0 -5 -5 ® ® rance a ClinCal Plasma Calibrator and ClinChek Test Data 00,5 1,0 1,5 2,0 2,5 3,0 3,5 4,0 4,5 5,0 00,5 1,0 1,5 2,0 2,5 3,0 3,5 4,0 4,5 5,0 Plasma Controls in two levels are available. Linearity: 0.04 - 20 μmol/l

Recovery: 100 % Retention Time (min) Retention Time (min) LOD: 0.02 μmol/l LLOQ: 0.04 μmol/l Malondialdehyde: 2.75 min Malondialdehyde: 2.75 min Intraassay precision: 3.7 % Interassay precision: 7.4 % Ordering Information Order No. Description Quantity

HPLC Parameters 32000 ClinRep® Complete Kit for Malondialdehyde in Plasma / Serum for 100 assays 1 pce. Pump: isocratic pump, flow rate: Kit Components (order no. 32000): 0.8 ml/min 32010 Mobile Phase 1000 ml Injection volume: 20 μl 32013 Plasma Calibrator, lyophil. 5 x 0.5 ml 32020 Derivatisation Vials 100 pcs. Injection interval: 5 min 32021 Sample Preparation Vials 100 pcs. Fluorescence 32022 Reagent A 70 ml detector: 515 nm (exc.), 553 nm (em.) 32023 Reagent B 20 ml 32024 Reagent C 20 ml HPLC-Thermostat: 30 °C Manual 1 pce. Quick Reference 1 pce.

Sample Preparation Start Accessories: Derivatisation: 32030 Analytical Column with test chromatogram 1 pce. 32031 Guard Column 5 pcs. 100 μl 700 μl 200 μl FK7000 manu-CART® cartridgeholder, one time accessory 1 set sample Reagent A Reagent B

➜ Accessories: incubate (60 min, 100 °C) FK5810 PEEK tubing (connection of prefilter and column) 1 pce. Neutralisation / Precipitation: FK5820 Stainless steel prefilter holder 1 pce. FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. 200 μl 200 μl sample Reagent C ClinChek® Controls:

➜ 32080 Plasma Control, lyophil., Level I 10 x 0.5 ml centrifuge HPLC Analysis: 32081 Plasma Control, lyophil., Level II 10 x 0.5 ml 32082 Plasma Control, lyophil., Level I, II 2 x 5 x 0.5 ml Inject 20 μl of the supernatant ➜ Reliable sample preparation

➜ Robust chromatography

➜ Injection interval: 5 min

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Vitamin C (ascorbic acid) is a potential scavenger Oxidative Stress ClinChek® Serum Control, Level I ClinChek® Serum Control, Level II to radicals and oxidants. The exposure to these spe - Diagnostics

cies is termed as ”oxidative stress”. Oxidative stress 80 80 is believed to contribute to the development of various 1.79 4.04 Vitamin C in Plasma 60 60 4.03 chronic diseases such as cardiovascular disease, diabetes, and cancer. An inadequate vitamin C status 40 40 is usually observed in cases of malnutrition, smoking, 20 20

Test Data 1.79 Intensity (mV) Intensity (mV) alcohol abuse, chronic toxications and stress. Also, Linearity: 0.5 - 300 mg/l 0 0 nursing women and elderly people are in danger of Recovery: 95 - 100 % 0 1 2 3 45 0 1 2 3 45 a low vitamin C status. The RECIPE test kit features LOD: 0.1 mg/l fast analysis (quick sample preparation, short run LLOQ: 0.5 mg/l Retention Time (min) Retention Time (min) time) and ensures reliable results. Intraassay precision: 5.9 % Vitamin C: 1.79 min, IS: 4.04 min Vitamin C: 1.79 min, IS: 4.03 min Interassay precision: 6.9 %

Ordering Information HPLC Parameters Order No. Description Quantity Pump: isocratic pump, ® flow rate: 1.3 ml/min 28000 ClinRep Complete Kit for Vitamin C in Plasma for 100 assays 1 pce.

Injection volume: 20 μl Kit Components (order no. 28000): Injection interval: 5 min 28010 Mobile Phase 1000 ml 28012 Precipitant P with Internal Standard, lyophil. 5 x 3 ml UV-Detector: 243 nm 28013 Serum Calibrator, lyophil. 5 x 0.5 ml HPLC-Thermostat: 30 °C 28014 Test Solution, lyophil. 5 x 1 ml 28015 Reconstitution Solution R 25 ml 28020 Sample Preparation Vials 100 pcs. Sample Preparation Manual 1 pce. Precipitation: Quick Reference 1 pce.

100 μl Precipitant P 100 μl sample Start Accessories: (contains Internal Standard IS) 28030 Analytical Column with test chromatogram 1 pce.

➜ 28032 Guard Column Holder incl. 1 Guard Column 1 pce. 1. incubate (10 min, + 4°C) 2. centrifuge HPLC Analysis: Accessories: 28033 Guard Column 5 pcs. Inject 20 μl of the supernatant FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. FK5821 Replacement filter for stainless steel prefilter holder 10 pcs.

ClinChek® Controls: 28080 Serum Control, lyophil., Level I 10 x 0.5 ml 28081 Serum Control, lyophil., Level II 10 x 0.5 ml 28082 Serum Control, lyophil., Level I, II 2 x 5 x 0.5 ml

➜ Quick sample preparation

➜ Injection interval: 5 min

➜ Reference materials with excellent stability available

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Vitamin A (retinol) and vitamin E (α-tocopherol) be - Vitamin Status ClinChek® Serum Control, Level I ClinChek® Serum Control, Level II long to the fat soluble class of vitamins. In contrast to Diagnostics 7 7 water soluble vitamins, an excessive administration 6 6 may lead to hypervitaminosis. Vitamin A deficiency 5 5

Vitamin A and E 1.82 4.91

is the leading cause of preventable blindness in 4.91 4 1.82 4 children and raises the risk of disease and death in Plasma 3 3 7.19 from severe infections. Vitamin E is an important

2 7.20 2 Intensity (mV) Intensity (mV) anti oxidant and is thought to have a role in preven - 1 1

ting atherosclerosis by inhibiting oxidation of low- Test Data 0 0 density lipoprotein (LDL). The RECIPE ClinRep® Linearity: Vitamin A: 012345678 012345678

Com plete Kit allows for the simultaneous analysis 0.02 - 5.0 mg/l, Retention Time (min) Retention Time (min) of both vitamins within a run time of 8 min. For qua- Vitamin E: Vitamin A: 1.82 min, IS: 4.91 min, Vitamin E: 7.20 min Vitamin A: 1.82 min, IS: 4.91 min, Vitamin E: 7.19 min lity assurance, reference materials with excellent 0.40 - 50 mg/l stability are available. Recovery: 92 - 98 % LOD: Vitamin A: 0.01 mg/l, Ordering Information Order No. Description Quantity Vitamin E: 0.30 mg/l

LLOQ: Vitamin A: 0.02 mg/l, 22000 ClinRep® Complete Kit for Vitamin A and E in Plasma for 100 assays 1 pce. Vitamin E: 0.40 mg/l Kit components (order no. 22000): Intraassay precision: Vitamin A: 1.4 %, 22010 Mobile Phase 1000 ml Vitamin E: 1.4 % 22011 Standard Solution 3 ml 22012 Precipitant P with Internal Standard 15 ml Interassay precision: Vitamin A: 5.0 %, 22013 Serum Calibrator, lyophil. 3 ml Vitamin E: 3.2 % 22020 Sample Preparation Vials with Reagent, lyophil. 2 x 22020 (2 x 50 pcs.) 22021 Reaction Vials 100 pcs. 22022 Stabilising Reagent S 10 ml HPLC Parameters Manual 1 pce. Pump: isocratic pump, Quick Reference 1 pce.

flow rate: 1.5 ml/min Start Accessories: Injection volume: 50 μl 22030 Analytical Column with test chromatogram 1 pce. ® Injection interval: 8 min FK7000 manu-CART cartridgeholder, one time accessory 1 set

UV-Detector: 325 / 295 nm Accessories: HPLC-Thermostat: 30 °C FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. Sample Preparation ® Extraction: ClinChek Controls: 8870 Serum Control, lyophil., Level I 10 x 5 ml 150 μl Precipitant P 8871 Serum Control, lyophil., Level II 10 x 5 ml 150 μl plasma / serum (contains Internal Standard IS) 8872 Serum Control, lyophil., Level III 10 x 5 ml

➜ 8873 Serum Control, lyophil., Level I, II, III 3 x 3 x 5 ml centrifuge Stabilisation: ➜ Quick sample preparation 100 μl 100 μl supernatant Stabilising Reagent S ➜ centrifuge HPLC Analysis: ➜ Injection interval: 8 min Inject 50 μl of the supernatant

➜ Reference materials with excellent stability available

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Vitamin B1 (thiamine, thiamine pyrophosphate Vitamin Status ClinChek® Whole Blood Control, Level I ClinChek® Whole Blood Control, Level II (TPP)) acts as coenzyme in the carbohydrate meta - Diagnostics bolism and is essential for the normal functioning 160 160 140 140

of the organism. Deficiency mainly occurs in under - 2.52 Vitamin B1 120 120 nourished people, alcoholics or in special clinical 100 100 situations (e.g. hemodialysis). A fully developed 80 80

in Whole Blood 2.52 deficiency syndrome is called ”BeriBeri”. With this 60 60 40 40 Intensity (mV) Intensity (mV) RECIPE test kit, vitamin B1 is determined as TPP. 20 20 5.09 5.10 The kit can be combined in a convenient manner Test Data 0 0

with the test kits for vitamin B2 and B6 (see combi Determination as TPP 012 34 56 012 34 56

kit, pages 68 - 69). Linearity: 1 - 200 μg/l Retention Time (min) Retention Time (min) Recovery: 95 - 100 % LOD: 0.5 μg/l TPP: 2.52 min, Thiamine: 5.10 min TPP: 2.52 min, Thiamine: 5.09 min LLOQ: 1 μg/l Intraassay precision: 2.7 % Ordering Information Order No. Description Quantity Interassay precision: 4.2 %

24000 ClinRep® Complete Kit for Vitamin B1 in Whole Blood for 100 assays 1 pce. HPLC Parameters Kit Components (order no. 24000): Pump: isocratic pump, 24010 Mobile Phase 1000 ml flow rate: 1.0 ml/min 24014 Test Solution 3 ml 24513 Whole Blood Calibrator, lyophil. 5 x 2 ml Pump (Reagent N): flow rate: 0.1 ml/min 24020 Sample Preparation Vials 2 x 24020 (2 x 100 pcs.) Injection volume: 50 μl 24021 Reagent A 50 ml Injection interval: 4 min 24023 Reagent C 5 ml 24024 Reagent D 10 ml Fluorescence 24025 Reagent E 10 ml detector: 376 nm (exc.), 435 nm (em.) 24626 Reagent N 250 ml 24027 Reagent S 5 ml HPLC-Thermostat: 35 °C Manual 1 pce. Quick Reference 1 pce. Sample Preparation Start Accessories: Extraction: 27030 Analytical Column with test chromatogram 1 pce. 27032 Guard Column Holder incl. 1 Guard Column 1 pce. 300 μl whole blood 500 μl Reagent A Accessories: ➜➜ 1. centrifuge 2. take off 400 μl supernatant 27033 Guard Column 5 pcs. FK2000 ClinLab® Peristaltic pump 1 pce. Stabilisation: FK2001 Replacement tubing for peristaltic pump 2 pcs. FK5121 T-Union (PEEK), 1/16" 1 pce. Add 50 μl Reagent S FK5810 PEEK-tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. ➜ Excellent sensitivity: Oxidation: ClinChek® Controls: 0.5 μg/l 450 μl sample 50 μl Reagent C 100 μl Reagent D 8874 Whole Blood Control, lyophil., Level I 10 x 2 ml 8875 Whole Blood Control, lyophil., Level II 10 x 2 ml ➜ add 100 μl Reagent E 8876 Whole Blood Control, lyophil., Level I, II 2 x 5 x 2 ml HPLC Analysis:

➜ Injection interval: 4 min Inject 50 μl of the supernatant

➜ Combinable with B2 and B6 test kits

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The term ”vitamin B2” covers three vitamers: ribo- Vitamin Status ClinChek® Whole Blood Control, Level I ClinChek® Whole Blood Control, Level II flavin, flavin mononucleotide (FMN) and flavin Diagnostics adenine dinucleotide (FAD). FMN and FAD are the 10 10 effective forms of vitamin B2 and are synthesised Vitamin B2 8 8 in vivo from riboflavin by phosphorylation. Vitamin 6 6 2.77

B2 is important for energy production, enzyme func- in Whole Blood 4 2.77 4

tions as well as for the fatty acid and amino acid 2 2 8.26 5.18 5.20 8.24 synthesis. The undersupply with vitamin B2 is most- Intensity (mV) 0 Intensity (mV) 0

ly attributed to a general malnutrition. It is often seen Test Data -2 -2 in persons with risk factors such as alcohol pro- Determination as FAD 0 1 2 3 4 5 6107 8 9 0 1 2 3 4 5 6107 8 9

blems, advanced age and extreme dietary habits. Linearity: 20 - 500 μg/l Retention Time (min) Retention Time (min) The RECIPE test kit features short time for analysis Recovery: 95 - 100 % LOD: 10 μg/l Flavin adenine dinucleotide: 2.77 min, Flavin adenine dinucleotide: 2.77 min, (easy sample preparation, short run time) and can Flavin mononucleotide: 5.20 min, Flavin mononucleotide: 5.18 min, be easily combined with test kits for the vitamins LLOQ: 20 μg/l Riboflavin: 8.24 min Riboflavin: 8.26 min B1 and B6 (see combi kit, pages 68 - 69). Intraassay precision: 3.8 % Interassay precision: 4.0 % Ordering Information Order No. Description Quantity HPLC Parameters ® Pump: isocratic pump, 25000 ClinRep Complete Kit for Vitamin B2 in Whole Blood for 100 assays 1 pce.

flow rate: 1.0 ml/min Kit Components (order no. 25000): Injection volume: 50 μl 25010 Mobile Phase 1000 ml 25014 Test Solution, lyophil. 5 x 2 ml Injection interval: 10 min 25015 Reconstitution Solution R 10 ml Fluorescence 24513 Whole Blood Calibrator, lyophil. 5 x 2 ml detector: 450 nm (exc.), 530 nm (em.) 25020 Sample Preparation Vials 100 pcs. 25021 Precipitant P 30 ml HPLC-Thermostat: 40 °C 25022 Stabilising Reagent S 50 ml Manual 1 pce. Quick Reference 1 pce. Sample Preparation Extraction: Start Accessories: 27030 Analytical Column with test chromatogram 1 pce. 200 μl whole blood 300 μl Precipitant P 27032 Guard Column Holder incl. 1 Guard Column 1 pce.

➜ Accessories: 1. add 500 μl Stabilising 2. centrifuge 27033 Guard Column 5 pcs. Reagent S HPLC Analysis: FK5810 PEEK-tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. Inject 50 μl of the supernatant FK5821 Replacement filter for stainless steel prefilter holder 10 pcs.

ClinChek® Controls: 8874 Whole Blood Control, lyophil., Level I 10 x 2 ml 8875 Whole Blood Control, lyophil., Level II 10 x 2 ml ➜ Quick sample preparation 8876 Whole Blood Control, lyophil., Level I, II 2 x 5 x 2 ml

➜ Injection interval: 10 min

➜ Combineable with B1 and B6 test kits

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Vitamin B6 consists of three vitamers: pyridoxine, Vitamin Status ClinChek® Whole Blood Control, Level I ClinChek® Whole Blood Control, Level II pyridoxal and pyridoxamine. The metabolically active Diagnostics coenzyme form of vitamin B6 is pyridoxal-5'-phos- 10 10 phate (PLP). Clinical signs of vitamin B6 deficiency Vitamin B6 in Plasma / 8 8 5.22

are mainly expressed in alterations of the skin, 6 5.24 6

neuro logical disorders, and anemias. In addition to Whole Blood 8.82 4 4

this, a low vitamin B6 status may be responsible for 8.82

an increase of the homocysteine plasma level (hyper - Intensity (mV) 2 Intensity (mV) 2

homocysteinemia, see pages 46 - 47, and 122 - 123). Test Data 0 0 The RECIPE ClinRep® Complete Kit allows for the Determination from plasma / from whole blood 0 1 2 3 4 5 6 7 8 910 0 1 2 3 4 5 6 7 8 910

de ter mination of the vitamin B6 forms pyridoxal and Linearity: Pyridoxal: Retention Time (min) Retention Time (min) PLP in plasma and whole blood. The test features 0.6 - 800 μg/l / Pyridoxal-5ʼ-phosphate: 5.24 min, Pyridoxal: 8.82 min Pyridoxal-5ʼ-phosphate: 5.22 min, Pyridoxal: 8.82 min high analytical sensitivity and can be easily com- 0.6 - 1200 μg/l bined with the test kits for the vitamins B1 and B2 Pyridoxal-5ʻ-phosphate: Ordering Information (see combi kit, pages 68 - 69). 0.6 - 800 μg/l / Order No. Description Quantity 0.6 - 1500 μg/l

Recovery: 95 - 100 % / 95 - 100 % 26000 ClinRep® Complete Kit for Vitamin B6 in Plasma / Whole Blood for 100 assays 1 pce. LOD: 0.4 μg/l for both ana- Kit Components (order no. 26000): lytes and both matrizes 26010 Mobile Phase 1000 ml LLOQ: 0.6 μg/l for both ana- 26011 Standard Solution 3 ml 26013 Serum Calibrator, lyophil. 3 ml lytes and both matrizes 26020 Sample Preparation Vials 100 pcs. Intraassay precision: Pyridoxal: 5.1 % / 8.4 % 26021 Precipitant P 10 ml Pyridoxal-5ʻ-phosphate: 24626 Reagent N 250 ml Manual 1 pce. 2.5 % / 2.3 % Quick Reference 1 pce. Interassay precision: Pyridoxal: 6.9 % / 9.2 % Optional Components: Pyridoxal-5ʻ-phosphate: 24513 Whole Blood Calibrator, lyophil. 5 x 2 ml 3.1 % / 2.9 % Start Accessories: 27030 Analytical Column with test chromatogram 1 pce. HPLC Parameters 27032 Guard Column Holder incl. 1 Guard Column 1 pce. Pump: isocratic pump, Accessories: flow rate: 1.0 ml/min 27033 Guard Column 5 pcs. Pump (Reagent N): flow rate: 0.2 ml/min FK2000 ClinLab® Peristaltic pump 1 pce. Injection volume: 50 μl FK2001 Replacement tubing for peristaltic pump 2 pcs. FK5121 T-Union (PEEK), 1/16" 1 pce. Injection interval: 10 min FK5810 PEEK-tubing (connection of prefilter and column) 1 pce. Fluorescence FK5820 Stainless steel prefilter holder 1 pce. FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. detector: 370 nm (exc.), 470 nm (em.) ➜ Excellent sensitivity: Temperature: 25 °C (or ambient) ClinChek® Controls: 8870 Serum Control, lyophil., Level I 10 x 5 ml 0.4 μg/l 8871 Serum Control, lyophil., Level II 10 x 5 ml Sample Preparation 8872 Serum Control, lyophil., Level III 10 x 5 ml Extraction: 8873 Serum Control, lyophil., Level I, II, III 3 x 3 x 5 ml 8874 Whole Blood Control, lyophil., Level I 10 x 2 ml 8875 Whole Blood Control, lyophil., Level II 10 x 2 ml ➜ Quick sample preparation 100 μl sample 100 μl Precipitant P 8876 Whole Blood Control, lyophil., Level I, II 2 x 5 x 2 ml ➜ centrifuge ➜ Injection interval: 10 min HPLC Analysis: Inject 50 μl of the supernatant ➜ Combineable with B1 and B2 test kits

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The combi kit enables the combined measurement Vitamin Status Sample Preparation Vitamin B1: see page 62, Vitamin B2: see page 64, Vitamin B6: see page 66 of the vitamins B1, B2, and B6. It consists of the Diagnostics chromatography kit (order no. 27000) and appro- Chromatograms See chromatograms on page 63 (Vitamin B1), priate sample preparation kits (order nos. 27001, Vitamin B1, B2 in 65 (Vitamin B2), and 67 (Vitamin B6) 27002, 27006). The chromatography is performed with a single column for all B-vitamins in subsequent Whole Blood and Ordering Information The combi kit consists of the chromatography kit (order no. 27000) and the series of measurement. For switching the parameter separate sample preparation kits (order nos. 27001, 27002 and 27006). (e.g. vitamin B1 --> vitamin B2) simply the para- B6 in Plasma / Whole meter settings have to be changed (see HPLC para meters). By selecting the appropriate sample Blood (Combikit) A: Chromatography preparation kits, the customer is flexible to choose Order No. Description Quantity

the parameters according to his needs. Test Data 27000 ClinRep® Chromatography Kit for Vitamin B1, B2 and B6 for 1000 assays 1 pce. On request Kit Components (order no. 27000): 27008 Mobile Phase A 4 x 27008 (4 x 2400 ml) HPLC Parameters Vitamin B1 27009 Mobile Phase B 2 x 27009 (2 x 1000 ml) 27030 Analytical Column with test chromatogram 1 pce. Pump (Mobile Phase A + B): flow rate 1 ml/min 27033 Guard Column 5 pcs. ratio A : B = 93 : 7 FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. Pump (Reagent N): flow rate 0.1 ml/min Manual 1 pce. Quick Reference 1 pce. Injection volume: 50 μl Injection interval: 6 min Accessories: 27032 Guard Column Holder incl. 1 Guard Column 1 pce. HPLC-Thermostat: 35 °C FK2000 ClinLab® Peristaltic pump 1 pce. Detector (exc. / em.): 376 nm / 435 nm FK2001 Replacement tubing for peristaltic pump 2 pcs. Retention times: FK5121 T-Union (PEEK), 1/16" 1 pce. FK5810 PEEK-tubing (connection of prefilter and column) 1 pce. Thiamine approx. 5.1 min FK5820 Stainless steel prefilter holder 1 pce. TPP approx. 2.5 min FK5821 Replacement filter for stainless steel prefilter holder 10 pcs.

ClinChek® Controls: HPLC Parameters Vitamin B2 8870 Serum Control, lyophil., Level I 10 x 5 ml Pump (Mobile Phase A + B): flow rate 1 ml/min 8871 Serum Control, lyophil., Level II 10 x 5 ml 8872 Serum Control, lyophil., Level III 10 x 5 ml ratio A : B = 80 : 20 8873 Serum Control, lyophil., Level I, II, III 3 x 3 x 5 ml Injection volume: 50 μl 8874 Whole Blood Control, lyophil., Level I 10 x 2 ml 8875 Whole Blood Control, lyophil., Level II 10 x 2 ml Injection interval: 10 min 8876 Whole Blood Control, lyophil., Level I, II 2 x 5 x 2 ml HPLC-Thermostat: 40 °C Detector (exc. / em.): 450 nm / 530 nm Retention times: Riboflavin approx. 8.2 min B: Sample Preparation FMN approx. 5.2 min Order No. Description Quantity ➜ High flexibility: FAD approx. 2.8 min 27001 ClinRep® Sample Preparation Kit for Vitamin B1 in Whole Blood for 100 assays 1 pce. 1 Chromatography kit Kit Components (order no. 27001): + 3 sample preparation kits HPLC Parameters Vitamin B6 Identical with order no. 24000 (s. page 63); Pump (Mobile Phase A + B): flow rate 1 ml/min 27002 ClinRep® Sample Preparation Kit for Vitamin B2 in Whole Blood for 100 assays 1 pce. ratio A : B = 100 : 0 Kit Components (order no. 27002): Pump (Reagent N): flow rate 0.2 ml/min Identical with order no. 25000 (s. page 65); Injection volume: 50 μl not included 27006 ClinRep® Sample Preparation Kit for Vitamin B6 in Plasma and Whole Blood for 100 assays 1 pce. }

Injection interval: 10 min Kit Components (order no. 27006): exception: Mobile Phase HPLC-Thermostat: 25 °C Identical with order no. 26000 (s. page 67); Detector (exc. / em.): 370 nm / 470 nm Retention times: Pyridoxal approx. 8.8 min PLP approx. 5.2 min

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The determination of 25-OH vitamin D (i.e. D2, D3) Vitamin Status ClinChek® Serum Control, Level I ClinChek® Serum Control, Level II is used for the assessment of the vitamin D status. Diagnostics The RECIPE HPLC complete kit enables a quick

and reliable quantification of both analytes from 1.5 1.5 8.94

25-OH Vitamin D2 / D3 8.94 plasma and serum. The sample preparation consists 1.0 1.0

of a simple precipitation step, a time consuming 6.87 in Plasma and Serum 0.5 0.5 7.83 6.89

solid phase extraction is not required. The subse- 7.84 0 0 quent HPLC analysis is performed with an injection Intensity (mV) Intensity (mV) interval of 10 min only. For system check, calibration Test Data 0 1 2 3 4 5 6 7 8 9 10 0 1 2 3 4 5 6 7 8 9 10 and internal quality control a ClinTest® Test Solu tion, Linearity: 3.0 - 500 μg/l (D2)

® a ClinCal Serum Calibrator (traceable to NIST 2.6 - 500 μg/l (D3) Retention Time (min) Retention Time (min) stand ard SRM 972) and ClinChek® Serum Controls Recovery: 99 - 104 % LOD: 1.1 μg/l (D2) 25-OH Vitamin D3: 6.89 min, 25-OH Vitamin D2: 7.84 min, 25-OH Vitamin D3: 6.87 min, 25-OH Vitamin D2: 7.83 min, are available. IS: 8.94 min IS: 8.94 min 1.0 μg/l (D3) LLOQ: 3.0 μg/l (D2) Ordering Information 2.6 μg/l (D3) Order No. Description Quantity Intraassay precision: 2.7 % (D2) 2.5 % (D3) 35000 ClinRep® Complete Kit for 25-OH Vitamin D2 / D3 in Plasma and Serum for 100 assays 1 pce.

Interassay precision: 3.7 % (D2) Kit Components (order no. 35000): 3.7 % (D3) 35010 Mobile Phase 1000 ml 35012 Internal Standard IS 50 ml 35013 Serum Calibrator, lyophil. 5 x 2 ml HPLC Parameters 35014 Test Solution, lyophil. 2 x 2 ml Pump: isocratic pump, 35020 Sample Preparation Vials with Reagent, lyophil. 100 pcs. 35021 Precipitant P 50 ml flow rate: 1.0 ml/min Manual 1 pce. Injection volume: 50 μl Quick Reference 1 pce. Injection interval: 10 min Start Accessories: UV-Detector: 264 nm 35030 Analytical Column with test chromatogram 1 pce. HPLC-Thermostat: 40 °C 35032 Guard Column Holder incl. 1 Guard Column 1 pce.

Accessories: Sample Preparation 35033 Guard Column 5 pcs. FK5810 PEEK tubing (connection of prefilter and column) 1 pce. Precipitation: FK5820 Stainless steel prefilter holder 1 pce. FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. 500 μl Precipitant P ClinChek® Controls: ➜ 35080 Serum Control, lyophil., Level I 10 x 2 ml 35081 Serum Control, lyophil., Level II 10 x 2 ml 1. Add 400 μl sample 35082 Serum Control, lyophil., Level I, II 2 x 5 x 2 ml 2. Add 400 μl Internal Standard IS

➜ Quick sample preparation ➜ mix, centrifuge (no solid phase extraction HPLC Analysis: required) Inject 50 μl of the supernatant

➜ Injection interval: 10 min

➜ Traceable to NIST standard SRM 972

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25-OH Vitamin D (i.e. D2, D3) is an important para - Vitamin Status ClinTest® Test Solution ClinCal® Serum Calibrator meter for the assessment of the vitamin D status. Diagnostics In addition to RECIPE's HPLC complete kit (see pages 70 - 71), a ClinRep® Complete Kit for UHPLC 0.85 0.95 0.75 1.31 25-OH Vitamin D2 / D3 0.85 1.67 0.65 0.75 systems is available. The UHPLC Complete Kit 1.67 0.55 1.49 0.65 features a significantly increased sam ple through- 0.45 0.55 in Plasma and Serum 0.45 0.35

0.35 1.31 put with reduced buffer consumption due to the very 0.25 0.25 1.49 0.15 0.15 Intensity (AU) short chromatography duration of only 2 minutes. with UHPLC Intensity (mV) 0.05 0.05 0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 For system check, calibration and internal quality control a ClinTest® Solution, a ClinCal® Serum Cali - Test Data brator (traceable to NIST standard SRM 972) and Retention Time (min) Retention Time (min) Linearity: 4.6 - 500 μg/l (D2) ClinChek® Serum Controls are available. 3.7 - 500 μg/l (D3) 25-OH Vitamin D3: 1.31 min, 25-OH Vitamin D2: 1.49 min, 25-OH Vitamin D3: 1.31 min, 25-OH Vitamin D2: 1.49 min, Recovery: 99 - 104 % IS: 1.67 min IS: 1.67 min LOD: 2.8 μg/l (D2) 2.2 μg/l (D3) Ordering Information LLOQ: 4.6 μg/l (D2) Order No. Description Quantity

3.7 μg/l (D3) 35100 ClinRep® Complete Kit for 25-OH Vitamin D2 / D3 in Plasma and Serum with UHPLC 1 pce. Intraassay precision: 4.3 % (D2) for 100 assays

4.6 % (D3) Kit Components (order no. 35100): Interassay precision: 5.9 % (D2) 35110 Mobile Phase 1000 ml 3.9 % (D3) 35012 Internal Standard IS 50 ml 35013 Serum Calibrator, lyophil. 5 x 2 ml 35014 Test Solution, lyophil. 2 x 2 ml UHPLC Parameters 35020 Sample Preparation Vials 100 pcs. 35021 Precipitant P 50 ml Pump: isocratic pump, Manual 1 pce. flow rate: 0.75 ml/min Quick Reference 1 pce. Injection volume: 5 μl Start Accessories: Injection interval: 2 min 35130 Analytical Column with test chromatogram 1 pce. UV-Detector: 264 nm ClinChek® Controls: HPLC-Thermostat: 40 °C 35080 Serum Control, lyophil., Level I 10 x 2 ml 35081 Serum Control, lyophil., Level II 10 x 2 ml 35082 Serum Control, lyophil., Level I, II 2 x 5 x 2 ml Sample Preparation Precipitation:

500 μl Precipitant P ➜

➜ First UHPLC Kit for 1. Add 400 μl sample Vitamin D 2. Add 400 μl Internal Standard IS ➜ mix, centrifuge UHPLC Analysis:

Inject 5 μl of the supernatant ➜ Injection interval: 2 min

➜ Traceable to NIST standard SRM 972

73 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:14 Seite 74 TDM

HPLC Complete Kits

ClinRep® TDM for Therapeutic Drug Monitoring

Antiarrhythmics Amiodarone in Plasma ...... 76 - 77 Antiasthmatics Antiasthmatics in Plasma ...... 78 - 79 Antiepileptic Drugs Antiepileptics in Serum ...... 80 - 81 Antiepileptics in Serum / Plasma, advanced ...... 82 - 83 Antiepileptics in Serum / Plasma with UHPLC ...... 84 - 85 Lamotrigine and Sulthiame in Plasma ...... 86 - 87 Levetiracetam (Keppra®) in Serum / Plasma – Manual sample preparation ...... 88 - 89 – with Gilson® ASPEC™ ...... 88 - 89 Immunosuppressants Mycophenolic Acid in Plasma ...... 90 - 91 Psychoactive Drugs Atypical Neuroleptics in Plasma / Serum – on-line Analysis ...... 92 - 93

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Cardiac arrhythmias are major causes of morbidity Antiarrhythmics ClinChek® Serum Control, Level I ClinChek® Serum Control, Level II and mortality throughout the world. Arrhythmias are controlled by medication of several drugs, such 6 6 as amiodarone, an antiarrhythmic agent that helps 5 5 TDM Amiodarone 4.93 to stabilise the normal rhythm of the heart. The re - 4 4 6.70 3 3 2.82 sorp tion rate and the biological availability of amio - in Plasma 2.82 darone is low and extremely variable. The therapy 2 2 Intensity (mV) Intensity (mV) 1 4.93 1 therefore requires a close monitoring for the ad just - 6.71 ment of the drug dosage. The RECIPE ClinRep® Test Data 0 0 Complete Kit allows for a quick, sensitive and relia- Linearity: 0.1 - 10 μg/ml 01234567 8 01234567 8

ble deter mination of amiodarone and the main meta - Recovery: 95 - 105 % Retention Time (min) Retention Time (min) bolite desethylamiodarone. The sample preparation LOD: 0.07 μg/ml LLOQ: 0.1 μg/ml IS: 2.82 min, Desethylamiodarone: 4.93 min, IS: 2.82 min, Desethylamiodarone: 4.93 min, consists of a simple precipitation step. Amiodarone: 6.71 min Amiodarone: 6.70 min Intraassay precision: Amiodarone: 2.1 %, Desethylamiod.: 2.5 % Ordering Information Interassay precision: Amiodarone: 4.0 %, Order No. Description Quantity Desethylamiod.: 4.2 % 20000 ClinRep® Complete Kit for Amiodarone in Plasma for 100 assays 1 pce.

HPLC Parameters Kit Components (order no. 20000): Pump: isocratic pump, 20010 Mobile Phase 1000 ml 20011 Standard Solution 3 ml flow rate: 0.8 ml/min 20012 Precipitant P with Internal Standard 15 ml Injection volume: 20 μl 20013 Serum Calibrator, lyophil. 3 ml Injection interval: 8 min 20020 Sample Preparation Vials with Reagent, lyophil. 2 x 20020 (2 x 50 pcs.) Manual 1 pce. UV/VIS-Detector: 255 nm Quick Reference 1 pce. HPLC-Thermostat: 30 °C Start Accessories: 20030 Analytical Column with test chromatogram 1 pce. Sample Preparation 20032 Guard Column Holder incl. 1 Guard Column 1 pce. Extraction: Accessories: 150 μl Precipitant P 20033 Guard Column 5 pcs. 100 μl sample (contains Internal Standard IS) FK5810 PEEK tubing (connection of prefilter and column) 1 pce.

➜ FK5820 Stainless steel prefilter holder 1 pce. centrifuge FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. HPLC Analysis:

ClinChek® Controls: Inject 20 μl of the supernatant 20080 Serum Control, lyophil., Level I 10 x 3 ml 20081 Serum Control, lyophil., Level II 10 x 3 ml 20082 Serum Control, lyophil., Level I, II 2 x 5 x 3 ml

➜ Simple and quick sample preparation

➜ Linearity over a wide range

➜ Short run time

77 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:14 Seite 78

Theophylline, theobromine and caffeine are termed Antiasthmatics ClinChek® Plasma Control, Level I ClinChek® Plasma Control, Level II as methylxanthines and are used in the manage- 20 20 3.26 3.29 ment of asthma bronchiale. Methylxanthines pro- 2.69 1.83 duce a relaxation of the bronchial smooth muscle 15 Antiasthmatics 15 TDM and thus are helping to open up constricted air-

10 10 5.85 ways (bronchodilators). The drug absorption and in Plasma 2.66 1.80 metabolism may be affected by many factors, 5

5.83 5

inclu ding co-medication with other drugs (e.g. Intensity (mV) Intensity (mV) several AEDs, see pages 80 - 89). A monitoring of Test Data 0 0

the plasma level is therefore essential to ensure Linearity: 1.3 - 50 mg/l 012345678 012345678

that therapeutic, but not toxic drug doses are Recovery: approx. 70 % Retention Time (min) Retention Time (min) applied. The RECIPE ClinRep® Complete Kit fea- LOD: Theophylline: 0.8 mg/l Theobromine: 0.6 mg/l Theobromine: 1.80 min, Theophylline: 2.66 min, Theobromine: 1.83 min, Theophylline: 2.69 min, tures simple and quick sample preparation, a cost- IS: 3.26 min, Caffeine: 5.83 min IS: 3.29 min, Caffeine: 5.85 min efficient analysis and ensures reliable results. Caffeine: 0.6 mg/l LLOQ: Theophylline: 1.7 mg/l Ordering Information Theobromine: 1.3 mg/l Order No. Description Quantity Caffeine: 1.4 mg/l Intraassay precision: 2.5 % 12000 ClinRep® Complete Kit for Antiasthmatics in Plasma for 100 assays 1 pce.

Interassay precision: 1.7 % Kit Components (order no. 12000): 12010 Mobile Phase 1000 ml 12011 Standard Solution 4 ml HPLC Parameters 12012 Precipitant P with Internal Standard 15 ml Pump: isocratic pump, 12013 Plasma Calibrator, lyophil. 3 ml flow rate: 1.5 ml/min 12020 Sample Preparation Vials with Reagent, lyophil. 2 x 12020 (2 x 50 pcs.) 12021 Diluting Solution D 25 ml Injection volume: 20 μl Manual 1 pce. Injection interval: 8 min Quick Reference 1 pce. UV/VIS-Detector: 273 nm Start Accessories: HPLC-Thermostat: 37 °C 12030 Analytical Column with test chromatogram 1 pce. FK7000 manu-CART® cartridgeholder, one time accessory 1 set

Sample Preparation Accessories: Extraction: FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. 150 μl Precipitant P 100 μl plasma FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. (contains Internal Standard IS)

➜ ClinChek® Controls: centrifuge Dilution: 12080 Plasma Control, lyophil., Level I 10 x 3 ml 12081 Plasma Control, lyophil., Level II 10 x 3 ml 50 μl supernatant 250 μl Diluting Solution D 12082 Plasma Control, lyophil., Level I, II 2 x 5 x 3 ml ➜ ➜ Simultaneous determination HPLC Analysis:

of 3 methylxanthines Inject 20 μl of the diluted supernatant

➜ Simple and quick sample preparation

➜ Low cost per test

79 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:14 Seite 80

Antiepileptic drugs (AED) are the mainstay of epi- Antiepileptic Drugs ClinChek® Serum Control, Level II, recorded at 205 nm: ClinChek® Plasma Control, Level II, recorded at 265 nm: lepsy treat ment. The medication enables the patient 160 16 to live free of epileptic seizures. Depending on the 1.90 3.83 3.43 2.74 type of epilepsy, several AEDs with diverse activity 1.65 4.25 Antiepileptics 120 TDM mechanisms may be used for the management of 12

80 6.13 the disease. For the monitoring of the drug level, this in Serum 8.02 2.01 1.39 ® 11.19 8 ClinRep Complete Kit allows for the simultaneous 8.00 4.98

40 12.56 determination of 13* AEDs and metabolites. Intensity (mV) Intensity (mV) Test Data 0 4 Linearity: Lamotrig., Sulthiame: * Carbamazepine, carbamazepine-epoxide, N-desmethylmeth- 0246810 12 14 0246 8 10 suximide, eslicarbazepine, ethosuximide, 10-hydroxycarbama- 0.5 - 50 μg/ml Retention Time (min) Retention Time (min) zepine, lamotrigine, oxcarbazepine, phenylethylmalonamide Other Antiepileptics: (PEMA), phenobarbital, phenytoin, primidone, sulthiame 0.3 - 300 μg/ml PEMA: 1.39 min, Ethosuximide: 1.65 min, Primidone: 2.01 min, Sulthiame: 1.90 min, Lamotrigine: 2.74 min, IS: 8.00 min 10-Hydroxy-carbamazepine: 3.43 min, Phenobarbital: 3.83 min, Recovery: 95 - 105 % N-Desmethylmethsuximide: 4.25 min, Carbamazepine-epoxide: LOD: Lamotrig., Sulthiame: 4.98 min, Oxcarbazepine: 6.13 min, IS: 8.02 min, Phenytoin: 0.2 μg/ml 11.19 min, Carbamazepine: 12.56 min Other Antiepileptics: Ordering Information 0.1 μg/ml Order No. Description Quantity LLOQ: Lamotrig., Sulthiame: 0.5 μg/ml 15000 ClinRep® Complete Kit for Antiepileptics in Serum for 100 assays 1 pce. Other Antiepileptics: Kit Components (order no. 15000): 0.3 μg/ml 15010 Mobile Phase 1000 ml Intraassay precision: 2.3 % 15011 Standard Solution Antiepileptics 3 ml 15012 Precipitant P with Internal Standard 15 ml Interassay precision: 2.8 % 15013 Serum Calibrator Antiepileptics, lyophil. 3 ml 15020 Sample Preparation Vials with Reagent, lyophil. 2 x 15020 (2 x 50 pcs.) HPLC Parameters 15021 Diluting Solution D 10 ml Manual 1 pce. Pump: isocratic pump, Quick Reference 1 pce. flow rate: 1.0 ml/min Optional Components: Injection volume: 10 μl 15111 Standard Solution for Lamotrigine and Sulthiame 3 ml Injection interval: 15 min 15113 Plasma Calibrator for Lamotrigine and Sulthiame, lyophil. 3 ml UV/VIS-Detector: Lamotrig., Sulthiame: 265 nm Start Accessories: Other Antiepileptics: 205 nm 15030 Analytical Column with test chromatogram 1 pce. HPLC-Thermostat: 55 °C 15032 Guard Column Holder incl. 1 Guard Column 1 pce.

Accessories: Sample Preparation 15033 Guard Column 5 pcs. FK5810 PEEK tubing (connection of prefilter and column) 1 pce. Extraction: FK5820 Stainless steel prefilter holder 1 pce. ➜ 150 μl Precipitant P FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. Simultaneous analysis of 100 μl sample (contains Internal Standard IS) ClinChek® Controls: 13 antiepileptic drugs ➜ centrifuge 15080 Serum Control Antiepileptics, lyophil., Level I 10 x 3 ml Dilution: 15081 Serum Control Antiepileptics, lyophil., Level II 10 x 3 ml 15082 Serum Control Antiepileptics, lyophil., Level I, II 2 x 5 x 3 ml 100 μl supernatant 100 μl Diluting Solution D 15180 Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I 10 x 3 ml ➜ 15181 Plasma Control for Lamotrigine and Sulthiame, lyophil., Level II 10 x 3 ml Efficient sample clean-up ➜ 15182 Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I, II 2 x 5 x 3 ml HPLC Analysis:

Inject 10 μl of the diluted supernatant ➜ Robust and fast chromatography (injection interval: 15 min)

81 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:14 Seite 82

In addition to the reliable ClinRep® Complete Kit Antiepileptic Drugs ClinChek® Serum Control, Level II (order no. 14081) ClinChek® Serum Control, Level II (order no. 14181) with order no. 15000 (see pages 80 - 81), RECIPE offers a new test kit with an advanced chromato- 30 30 2.46 graphy and an extended analyte spectrum. The kit 0.77 1.48 TDM 25 2.94 25

Antiepileptics 3.25

features simultaneous quantification of 16 different 20 20 1.69 1.07

antiepileptics and clinically relevant metabolites, in - 15 15 1.85 in Serum / Plasma, 1.65 10 10 7.45 1.35 7.45 1.24 4.11

cluding novel drugs such as rufinamide, lacosamide 12.74

5 5.57 5 12.13 and eslicarbazepine. By use of the same analytical advanced Intensity (mV) 0 Intensity (mV) 0 -5 -5 column the kit can easily be combined with the 0 2 4 6 8 10 12 14 0 2 4 6 8 10 12 14 ClinRep® Complete Kit for Levetiracetam (see pages Test Data 88 - 89). Retention Time (min) Retention Time (min) The test data are available on request. Ethosuximide: 0.77 min, Primidone: 1.07 min, Sulthiame: Lacosamide: 1.24 min, Zonisamide: 1.48 min, Felbamate: HPLC Parameters 1.35 min, Lamotrigine: 1.65 min, 10-Hydroxy-Carbamazepine: 1.69 min, Rufinamide: 1.85 min, N-Desmethylmethsuximide: 2.46 min, Phenobarbital: 2.94 min, Carbamazepine-epoxide: 3.25 min, IS: 7.45 min Pump: isocratic pump, 4.11 min, Oxcarbazepine: 5.57 min, IS: 7.45 min, flow rate: 1.8 ml/min Carbamazepine: 12.13 min, Phenytoin: 12.74 min Injection volume: 10 μl Injection interval: 15 min (9 min*) Ordering Information UV-Detector: 205 nm Order No. Description Quantity HPLC-Thermostat: 30 °C 14000 ClinRep® Complete Kit, advanced, for Antiepileptics in Serum / Plasma for 100 assays 1 pce.

Kit Components (order no. 14000): * In case samples do not contain carbamazepine and phenytoin, 14010 Mobile Phase 1000 ml the injection interval can be reduced to 9 min. 14011 Standard Solution Antiepileptics 3 3 ml 14012 Precipitant P with Internal Standard 20 ml Sample Preparation 14013 Serum Calibrator Antiepileptics 3, lyophil. 3 ml 14020 Sample Preparation Vials 100 pcs. Precipitation: 14021 Diluting Solution D 25 ml 200 μl Precipitant P Manual 1 pce. 100 μl sample (contains Internal Standard) Quick Reference 1 pce. ➜ centrifuge Optional Components: Dilution: 14111 Standard Solution Antiepileptics 4 3 ml 15111 Standard Solution for Lamotrigine and Sulthiame 3 ml 150 μl supernatant 250 μl Diluting Solution D 14113 Serum Calibrator Antiepileptics 4, lyophil. 3 ml 15113 Plasma Calibrator for Lamotrigine and Sulthiame, lyophil. 3 ml ➜

HPLC Analysis: Start Accessories: 14030 Analytical Column with test chromatogram 1 pce. Inject 10 μl of the diluted supernatant Accessories: FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. ➜ Advanced chromatography FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. with 16 AEDs ClinChek® Controls: 14080 Serum Control Antiepileptics 3, lyophil., Level I 10 x 3 ml 14081 Serum Control Antiepileptics 3, lyophil., Level II 10 x 3 ml 14082 Serum Control Antiepileptics 3, lyophil., Level I, II 2 x 5 x 3 ml 14180 Serum Control Antiepileptics 4, lyophil., Level I 10 x 3 ml ➜ Injection interval: 14181 Serum Control Antiepileptics 4, lyophil., Level II 10 x 3 ml 14182 Serum Control Antiepileptics 4, lyophil., Level I, II 2 x 5 x 3 ml 15 min (9 min) 15180 Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I 10 x 3 ml 15181 Plasma Control for Lamotrigine and Sulthiame, lyophil., Level II 10 x 3 ml 15182 Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I, II 2 x 5 x 3 ml

➜ 1 analytical column for 16 AEDs and Levetiracetam

83 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:14 Seite 84

This new ClinRep® UHPLC Complete Kit shows an Antiepileptic Drugs ClinChek® Serum Control, Level II (order no. 14081) ClinChek® Serum Control, Level II (order no. 14181) identical analyte spectrum as the ClinRep® HPLC Complete Kit with order no. 14000 (see pages 82 - 0.14 0.100 0.090

0.12 2.33 0.080 1.86 83). Thus, the following 16 substances can be 2.80 0.070 TDM Antiepileptics 0.10 1.99 1.39 quanti fied simultaneously: carbamazepine, eslicar- 0.060 3.44 2.05

0.08 2.65 0.050 1.71 3.71 1.92

bazepine, ethosuximide, felbamate, lacosamide, 3.44 in Serum / Plasma 0.06 0.040 1.79 3.64 lamotrigine, oxcarbazepine, phenobarbital, pheny - 0.04 3.16 0.030 2.92

1.80 0.020 Intensity (AU) Intensity (AU) 0.02 toin, primidone, rufinamide, sulthiame and zonisa- with UHPLC 0.010 mide as well as the pharmacologically active meta- 0.00 0.000 0.00 0.50 1.00 1.50 2.00 2.50 3.00 3.50 4.00 0.00 0.50 1.00 1.50 2.00 2.50 3.00 3.50 4.00 bolites N-desmethylmethsuximide, 10-hydroxy-car - Test Data ba mazepine and carbamazepine-epoxide. The chro - Retention Time (min) Retention Time (min) The test data are available on request. matographic separation is performed with an injec- Ethosuximide: 1.39 min, Primidone: 1.71 min, Sulthiame: Lacosamide: 1.79 min, Zonisamide: 1.86 min, Felbamate: tion interval of 5 min only. UHPLC Parameters 1.80 min, Lamotrigine: 1.92 min, 10-Hydroxy-Carbamazepine: 1.99 min, Rufinamide: 2.05 min, N-Desmethylmethsuximide: 2.33 min, Phenobarbital: 2.65 min, Carbamazepine-epoxide: 2.80 min, IS: 3.44 min Pump: binary gradient pump, 2.92 min, Oxcarbazepine: 3.16 min, IS: 3.44 min, flow rate: 0.4 ml/min Carbamazepine: 3.64 min, Phenytoin: 3.71 min Injection volume: 2 μl Injection interval: 5 min Ordering Information UV-Detector: 205 nm Order No. Description Quantity HPLC-Thermostat: 30 °C 14100 ClinRep® Complete Kit for Antiepileptics in Serum / Plasma for 100 assays 1 pce.

Sample Preparation Kit Components (order no. 14100): 14108 Mobile Phase A 400 ml Precipitation: 14109 Mobile Phase B 200 ml 14011 Standard Solution Antiepileptics 3 3 ml 200 μl Precipitant P 100 μl sample 14012 Precipitant P with Internal Standard 20 ml (contains Internal Standard) 14013 Serum Calibrator Antiepileptics 3, lyophil. 3 ml ➜ centrifuge 14020 Sample Preparation Vials 100 pcs. Dilution: 14021 Diluting Solution D 25 ml Manual 1 pce. 150 μl supernatant 250 μl Diluting Solution D Quick Reference 1 pce.

➜ Optional Components: UHPLC Analysis: 14111 Standard Solution Antiepileptics 4 3 ml 15111 Standard Solution for Lamotrigine and Sulthiame 3 ml Inject 2 μl of the diluted supernatant 14113 Serum Calibrator Antiepileptics 4, lyophil. 3 ml 15113 Plasma Calibrator for Lamotrigine and Sulthiame, lyophil. 3 ml

Start Accessories: 14130 Analytical Column with test chromatogram 1 pce.

ClinChek® Controls: 14080 Serum Control Antiepileptics 3, lyophil., Level I 10 x 3 ml ➜ Simultaneous determina- 14081 Serum Control Antiepileptics 3, lyophil., Level II 10 x 3 ml 14082 Serum Control Antiepileptics 3, lyophil., Level I, II 2 x 5 x 3 ml tion of 16 AEDs including: 14180 Serum Control Antiepileptics 4, lyophil., Level I 10 x 3 ml 14181 Serum Control Antiepileptics 4, lyophil., Level II 10 x 3 ml – Lacosamide 14182 Serum Control Antiepileptics 4, lyophil., Level I, II 2 x 5 x 3 ml 15180 Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I 10 x 3 ml – Zonisamide 15181 Plasma Control for Lamotrigine and Sulthiame, lyophil., Level II 10 x 3 ml – Felbamate 15182 Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I, II 2 x 5 x 3 ml – Rufinamide – Eslicarbazepine

➜ Injection interval: 5 min

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Lamotrigine and sulthiame are important antiepileptic Antiepileptic Drugs ClinChek® Plasma Control, Level I: ClinChek® Plasma Control, Level II: drugs (AED) in the management of several types of epilepsy. This ClinRep® Complete Kit is especially 25 25 1.75 20 20 2.45 4.64

designed for the determination of lamotrigine and 4.64 Lamotrigine and TDM sulthiame from plasma. It features a short time for 15 15

10 10

analysis (7 min) and excellent test precision. 1.74 Sulthiame in Plasma 2.44 5 5

Intensity (mV) 0 Intensity (mV) 0 Test Data Linearity: 0.5 - 50 μg/ml 012 34 56 012 34 56

Recovery: 95 - 105 % Retention Time (min) Retention Time (min) LOD: 0.2 μg/ml LLOQ: 0.5 μg/ml Sulthiame: 1.74 min, Lamotrigine: 2.44 min, IS: 4.64 min Sulthiame: 1.75 min, Lamotrigine: 2.45 min, IS: 4.64 min Intraassay precision: 2.4 % Interassay precision: 2.6 % Ordering Information Order No. Description Quantity

HPLC Parameters 15100 ClinRep® Complete Kit for Lamotrigine, Sulthiame in Plasma for 100 assays 1 pce. Pump: isocratic pump, Kit Components (order no. 15100): flow rate: 1.0 ml/min 15010 Mobile Phase 1000 ml Injection volume: 20 μl 15111 Standard Solution 3 ml 15112 Precipitant P with Internal Standard 15 ml Injection interval: 7 min* 15113 Plasma Calibrator, lyophil. 3 ml UV/VIS-Detector: 265 nm 15020 Sample Preparation Vials with Reagent, lyophil. 2 x 15020 (2 x 50 pcs.) HPLC-Thermostat: 55 °C 15021 Diluting Solution D 10 ml Manual 1 pce. Quick Reference 1 pce. * In case the sample contains carbamazepine, the run time must be extended to 15 min. Start Accessories: 15030 Analytical Column with test chromatogram 1 pce. 15032 Guard Column Holder incl. 1 Guard Column 1 pce. Sample Preparation Extraction: Refill Service: 15031 Analytical Column with test chromatogram (original column needs to be returned) 1 pce. 150 μl Precipitant P 100 μl plasma (contains Internal Standard IS) Accessories:

➜ 15033 Guard Column 5 pcs. centrifuge Dilution: FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. 100 μl supernatant 100 μl Diluting Solution D

➜ ClinChek Controls: HPLC Analysis: 15180 Plasma Control, lyophil., Level I 10 x 3 ml 15181 Plasma Control, lyophil., Level II 10 x 3 ml 15182 Plasma Control, lyophil., Level I, II 2 x 5 x 3 ml ➜ Injection interval: 7 min Inject 20 μl of the diluted supernatant

➜ Excellent test precision

87 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:14 Seite 88

The RECIPE analytical method for levetiracetam Antiepileptic Drugs ClinChek® Serum Control, Level I ClinChek® Serum Control, Level II completes the RECIPE kit portfolio for the analysis of antiepileptic drugs (AED). The sample preparation can be performed either manually (complete kit ® 14 14 12 12 TDM Levetiracetam (Keppra ) 2.57

® 4.93

with order no. 15500) or automated with the Gilson 10 4.93 10 8 8 ASPEC™ pipetting system (order no. 15600). By 6 6 in Serum and Plasma 2.58 the use of the same analytical column, the kits can 4 4 2 2 Intensity (mV) Intensity (mV) easily be combined with the AED test kit with order – Manual Sample Preparation 0 0 no. 14000 (see pages 82 - 83) which allows the – with Gilson® ASPEC™ 0 1 2 3 4 5 6 0 1 2 3 4 5 6 quantification of further 16 different drugs and clini-

cally relevant metabolites. Retention Time (min) Retention Time (min) Test Data Levetiracetam: 2.58 min, IS: 4.93 min Levetiracetam: 2.57 min, IS: 4.93 min Manual / Automated Processing (Gilson® ASPEC™)

Linearity: 0.5 - 1000 / 0.5 - 200 mg/l Ordering Information Recovery: 97 - 105 / 90 - 102 % Order No. Description Quantity LOD: 0.15 mg/l ® LLOQ: 0.5 mg/l ClinRep Complete Kit for Levetiracetam in Serum / Plasma 15500 – manual sample preparation, for 100 assays 1 pce. Intraassay precision: 1.5 / 1.2 % 15600 – with Gilson® ASPEC™, for 200 assays 1 pce. Interassay precision: 1.9 / 1.9 % Kit Components : – order no. 15500 HPLC Parameters 15510 Mobile Phase 1000 ml Pump: isocratic pump, 15520 Sample Preparation Columns 2 x 15520 (2 x 50 pcs.) 15522 Washing Solution W1 3 x 15522 (3 x 200 ml) flow rate: 1.4 ml/min – order no. 15600 Injection volume: 20 μl 15510 Mobile Phase 2 x 15510 (2 x 1000 ml) 15620 Sample Preparation Columns 2 x 15620 (2 x 100 pcs.) Injection interval: 6 min 15522 Washing Solution W1 2 x 15522 (2 x 200 ml) UV-Detector: 205 nm – order nos. 15500 / 15600 HPLC-Thermostat: 30 °C 15511 Standard Solution 3 ml 15512 Internal Standard IS 10 ml 15513 Serum Calibrator, lyophil. 3 ml Sample Preparation 15521 Conditioning Reagent C 300 ml 15523 Washing Solution W2 100 ml ® Manual / Automated Processing (Gilson ASPEC™) 15524 Eluting Reagent E 100 ml Extraction: Manual 1 pce. Quick Reference 1 pce. Apply (conditioned* sample preparation column): Sample Internal Standard IS Start Accessories: (100 μl / 50 μl) (100 μl / 50 μl) 14030 Analytical Column with test chromatogram 1 pce. ➜ wash with 1. Washing Solution W1 Accessories: (3 ml / 1 ml) FK5810 PEEK tubing (connection of prefilter and column) 1 pce. ➜ 1 analytical column for 2. Washing Solution W2 FK5820 Stainless steel prefilter holder 1 pce. (1 ml / 330 μl) FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. levetiracetam and further Elution: Apply Eluting Reagent E ClinChek® Controls: 16 AEDs (1 ml / 500 μl) 15580 Serum Control, lyophil., Level I 10 x 3 ml

➜ 15581 Serum Control, lyophil., Level II 10 x 3 ml HPLC Analysis: 15582 Serum Control, lyophil., Level I, II 2 x 5 x 3 ml

➜ Optional: method Inject 20 μl with automated * Conditioning with Conditioning Reagent C and Washing Solution W1 sample preparation

89 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:14 Seite 90

Mycophenolate mofetil (MMF) belongs to the newer Immunosuppressants ClinChek® Plasma Control, Level I: ClinChek® Plasma Control, Level II: immunosuppressive drugs and is usually used in combination with cyclosporine A or tacrolimus. As a 70 70 pro-drug, MMF is rapidly hydrolised in vivo to its 60 60 TDM Mycophenolic Acid 50 50 active constituent mycophenolic acid (MPA). In order 40 40 to reach an optimal therapeutic efficiency, i.e. to in Plasma 30 30 6.05 4.99 maxi mise drug efficiency while minimising its toxi- 20 6.05 20 Intensity (mV) Intensity (mV) city, the administration of MMF requires monitoring 10 10 4.99 of the MPA concentration with subsequent do sage Test Data 0 0

adjustment. For this purpose, our ClinRep® HPLC Linearity: 0.1 - 40 mg/l 012 34 56 7 012 34 56 7

Complete Kit provides an easy and quick sample Recovery: 95 - 105 % Retention Time (min) Retention Time (min) preparation and enables a reliable and fast analysis. LOD: 0.06 mg/l LLOQ: 0.1 mg/l Mycophenolic acid: 4.99 min, IS: 6.05 min Mycophenolic acid: 4.99 min, IS: 6.05 min Intraassay precision: 3.3 % Interassay precision: 4.0 % Ordering Information Order No. Description Quantity

HPLC Parameters 29000 ClinRep® Complete Kit for Mycophenolic Acid in Plasma for 100 assays 1 pce. Pump: isocratic pump, Kit Components (order no. 29000): flow rate: 1.2 ml/min 29010 Mobile Phase 1000 ml Injection volume: 50 μl 29014 Test Solution 3 ml 29012 Internal Standard IS 2 ml Injection interval: 7 min 29013 Plasma Calibrator, lyophil. 3 ml UV/VIS-Detector: 215 nm 29020 Sample Preparation Vials 100 pcs. HPLC-Thermostat: 30 °C 29021 Precipitant P 20 ml Manual 1 pce. Quick Reference 1 pce. Sample Preparation Start Accessories: Precipitation: 29030 Analytical Column with test chromatogram 1 pce. 20 μl Internal 200 μl 100 μl plasma Standard IS Precipitant P Accessories: FK5810 PEEK-tubing (connection of prefilter and column) 1 pce. ➜ centrifuge FK5820 Stainless steel prefilter holder 1 pce. HPLC Analysis: FK5821 Replacement filter for stainless steel prefilter holder 10 pcs.

Inject 50 μl of the supernatant ClinChek® Controls: 29080 Plasma Control, lyophil., Level I 10 x 3 ml 29081 Plasma Control, lyophil., Level II 10 x 3 ml 29082 Plasma Control, lyophil., Level III 10 x 3 ml 29083 Plasma Control, lyophil., Level I, II, III 3 x 3 x 3 ml

➜ Easy and quick sample preparation

➜ Reliable chromatography

➜ Injection interval: 7 min

91 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:14 Seite 92

The drugs olanzapine, clozapine, quetiapine, ris- Chromatogram of the plasma calibrator, order no. 40013 Chromatogram of the plasma calibrator, order no. 40113 Psychoactive Drugs (+ 20 μl Internal Standard IS per ml sample, order no. 40012) (+ 10 μl Internal Standard IS per ml sample, order no. 40012) peridone, and paliperidone (= 9-OH-risperidone) be long to the class of the so called ”atypical” neu - ro leptics and are used for the treatment of schizo- 8 Atypical Neuroleptics TDM 12 6 phrenia. Co-medication, smoking, caffeine and food 16.65 12.27

10 18.55 are factors that extensively influence their metabo- in Plasma / Serum – 8 4 10.47

lism and thus lead to a high intra- and interindividual 6 11.68

4 14.43 2 20.25

variability of drug concentrations in blood. In order to on-line Analysis 11.15 2 9.51 Intensity (mV) Intensity (mV) 0 avoid severe side effects by overdosing and to en - 0

sure an optimal therapeutic effect, therapeutic drug 8229 10 11 12 13 14 15 16 17 18 19 20 21 Test Data 92010 11 12 13 14 15 16 17 18 19 monitoring (TDM) is required. The RECIPE Com plete Linearity: Olz / D-Olz: Kit represents a fully automated, robust on-line SPE Retention Time (min) Retention Time (min) 5 / 10 - 1000 μg/l technique, that allows for a direct sample injection Clz / D-Clz: Desmethylolanzapine (D-Olz): 9.51 min, Olanzapine (Olz): Paliperidone (Plp): 10.47 min, Risperidone (Rsp): 11.68 min, into the HPLC system. 11.15 min, Desmethylclozapine (D-Clz): 12.27 min, Internal Internal Standard IS: 16.65 min 6 / 5 - 5000 μg/l Standard IS: 14.43 min, Clozapine (Clz): 18.55 min, Qtp: 10 - 2000 μg/l Quetiapine (Qtp): 20.25 min Plp, Rsp: 1 - 200 μg/l Recovery: 100 % Ordering Information LOD: 2 μg/l (Olz, Clz, D-Clz), Order No. Description Quantity 4 μg/l (D-Olz, Qtp) 40000 ClinRep® Complete Kit for Atypical Neuroleptics in Plasma / Serum 1 pce. 0.4 μg/l (Plp, Rsp) for 100 assays LLOQ: 5 μg/l (Olz), 6 μg/l (Clz), 10 μg/l (D-Olz, Qtp), Kit Components (order no. 40000): 40009 SPE-Buffer 2 x 40009 (2 x 1000 ml) 4 μg/l (D-Clz) 40010 Mobile Phase 2 x 40010 (2 x 2000 ml) 1 μg/l (Plp, Rsp) 40013 Plasma Calibrator, lyophil. 5 x 3 ml Manual 1 pce. Intraassay precision: 0.2 - 2 % Quick Reference 1 pce. Interassay precision: 1 - 6 % Optional Components: 40012 Internal Standard IS 2 ml HPLC Parameters 40014 Test Solution, lyophil. 5 x 2 ml A: Determination of Olz, D-Olz, Clz, D-Clz, Qtp 40113 Plasma Calibrator, lyophil., for Risperidone and Paliperidone 5 x 5 ml 40114 Test Solution, for Risperidone and Paliperidone 15 ml B: Determination of Plp, Rsp Isocratic pump 1 Start Accessories: 40030 Analytical Column with test chromatogram 1 pce. (SPE-buffer): flow rates: 0.5 / 1.0 ml/min 40031 SPE-Column 1 pce. Isocratic pump 2 40032 Guard Column Holder incl. 1 Guard Column 1 pce. (mobile phase): flow rate: A: 1.3 ml/min 40033 Guard Column 5 pcs. FK7400 Inline-Filter (stainless steel sieve, free of dead volume) 1 pce. B: 1.0 ml/min Switching valve: 6-port/3-channel Refill Service: ➜ Fully automated method 40034 SPE-Column, refill (original column needs to be returned) 1 pce. (order no. FK1102) Injection volume: A: 250 μl, B: 750 μl Accessories: Injection interval: A: 22 min, B: 20 min FK1102 Switching valve, Sykam (6-port/3-channel) incl. electr. drive, PEEK 1 pce. FK7340 Sealings and sieves 4 pcs. each ➜ on-line sample UV-detector: A: 254 nm, B: 280 nm HPLC-thermostat: 30 °C ClinChek® Controls: preparation 40080 Plasma Control, lyophil., Level I 10 x 3 ml 40081 Plasma Control, lyophil., Level II 10 x 3 ml Sample Pretreatment 40082 Plasma Control, lyophil., Level I, II 2 x 5 x 3 ml Addition of IS: 40180 Plasma Control, lyophil., for Risperidone and Paliperidone, Level I 10 x 5 ml 40181 Plasma Control, lyophil., for Risperidone and Paliperidone, Level II 10 x 5 ml ➜ 100 % recovery A: Add 20 μl Internal Standard IS/ml sample 40182 Plasma Control, lyophil., for Risperidone and Paliperidone, Level I, II 2 x 5 x 5 ml B: Add 10 μl Internal Standard IS/ml sample ➜ centrifuge on-line Analysis:

A: Inject 250 μl B: Inject 750 μl

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HPLC Complete Kits

ClinTox® HBM for Human Biomonitoring

Benzene and Derivatives ortho-Cresol and Phenol in Urine . . . . . 96 - 97 Hippuric Acid and Methylhippuric Acids in Urine ...... 98 - 99 t,t-Muconic Acid in Urine ...... 100 - 101 Polycyclic Aromatic Hydrocarbons (PAH) 1-Hydroxypyrene in Urine – on-line Analysis ...... 102 - 103

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o-Cresol is a minor metabolite of toluene and ser- Benzene and Derivatives ClinChek® Urine Control, Level I: ClinChek® Urine Control, Level II: ves for the assessment of an exposure to toluene, which is a frequently used solvent in glues, paints and thinners. In contrast to hippuric acid (see pages 1000 1000

ortho-Cresol and 5.62 9.87 98 - 99), which is the main metabolite of toluene, 9.87

o-cresol is not a physiological component of urine 500 500 Phenol in Urine 5.62 and therefore reflects the internal exposure to wards 11.07 11.06 12.39 12.39 Intensity (mV) Intensity (mV) the pollu tant. Phenol is the main metabolite of ben- 0 0 HBM Test Data -149 -149 zene and is used for the assessment of benzene 0246 8 10 12 14 0246 8 10 12 14 as well as of phenol itself. The RECIPE ClinTox® Linearity: o-Cresol: 0.05 - 50 mg/l,

Com plete Kit provides an excellent analytical sen- Phenol: 0.2 - 50 mg/l Retention Time (min) Retention Time (min) sitivity and ensures a reliable biomonitoring of both Recovery: 85 - 95 % LOD: o-Cresol: 0.03 mg/l, Phenol: 5.62 min, p-Cresol: 9.87 min, o-Cresol: 11.06 min, Phenol: 5.62 min, p-Cresol: 9.87 min, o-Cresol: 11.07 min, analytes. The sample clean up is performed via IS: 12.39 min IS: 12.39 min solid phase extrac tion (SPE). Phenol: 0.1 mg/l LLOQ: o-Cresol: 0.05 mg/l, Ordering Information Phenol: 0.2 mg/l Order No. Description Quantity Intraassay precision: o-Cresol: 2.4 %, Phenol: 3.2 % 53000 ClinTox® Complete Kit for o-Cresol and Phenol in Urine for 100 assays 1 pce.

Interassay precision: o-Cresol: 2.8 %, Kit Components (order no. 53000): Phenol: 4.8 % 53010 Mobile Phase 1000 ml 53012 Internal Standard IS 5 ml 9925 Urine Calibrator, lyophil. 5 x 5 ml HPLC Parameters 52320 Sample Preparation Columns 2 x 52320 (2 x 50 pcs.) Pump: isocratic pump, 53021 Reagent A 400 ml 53022 Reagent B 2 x 53022 (2 x 300 ml) flow rate: 1.0 ml/min 53023 Reagent C 25 ml Injection volume: 10 - 20 μl 53024 Reagent D 3 x 53024 (3 x 2 ml) Manual 1 pce. Injection interval: 15 min Quick Reference 1 pce. Fluorescence detector: 277 nm (exc.), 300 nm (em.) Start Accessories: 52330 Analytical Column with test chromatogram 1 pce. HPLC-Thermostat: 30 °C Accessories: FK5810 PEEK tubing (connection of prefilter and column) 1 pce. Sample Preparation FK5820 Stainless steel prefilter holder 1 pce. Enzymatic treatment: FK5821 Replacement filter for stainless steel prefilter holder 10 pcs.

250 μl 50 μl Internal 50 μl 250 μl urine ClinChek® Controls: Reagent C Standard IS Reagent D 8925 Urine Control, lyophil., Level I, II 2 x 5 x 5 ml ➜ incubate (37 °C, 2 - 24 h) Extraction:

Transfer the whole sample to a conditioned ➜ Enzymatic release sample preparation column ➜ of the analytes wash (2 x 2 ml Reagent B) Elution:

Elute with 2 ml Reagent A

➜ ➜ Sample clean-up via SPE collect the eluate HPLC Analysis:

Inject 10 - 20 μl ➜ Injection interval: 15 min

➜ High analytical sensitivity

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This ClinTox® Complete Kit is designed for the Benzene and Derivatives ClinChek® Urine Control, Level I: ClinChek® Urine Control, Level II: reliable biomonitoring of hippuric acid and of o-, m-

and p-methylhippuric acid. Those compounds are 160 160 3.24 3.19 the uri nary metabolites of toluene and of the cor - 140 140 Hippuric Acid and 120 120 res pon ding xylenes and thus reflect an exposure 100 100 level towards these pollutants. Sample preparation Methylhippuric Acids 80 80 60 60 5.14 co lumns and ana ly ti cal column of this kit can also 5.07 40 40 6.52 Intensity (mV) Intensity (mV) HBM 4.29 be used for the determination of o-cresol and phenol in Urine 6.43 20 4.23 20 in urine (see pages 96 - 97). 0 0 012 34 56 7 8 012 34 56 7 8 Test Data Retention Time (min) Retention Time (min) Linearity: Hippuric Acid: 50 - 10000 mg/l, Hippuric acid: 3.19 min, o-Methylhippuric acid: 4.23 min, Hippuric acid: 3.24 min, o-Methylhippuric acid: 4.29 min, Methylhippuric Acids: IS: 5.07 min, m-/p-Methylhippuric acid: 6.43 min IS: 5.14 min, m-/p-Methylhippuric acid: 6.52 min 5 - 5000 mg/l Recovery: 85 - 95 % Ordering Information LOD: Hippuric Acid: 30 mg/l, Order No. Description Quantity

Methylhip. Acids: 2 mg/l 52000 ClinTox® Complete Kit for Hippuric Acid and Methylhippuric Acids in Urine 1 pce. LLOQ: Hippuric Acid: 50 mg/l, for 100 assays

Methylhip. Acids: 4 mg/l Kit Components (order no. 52000): Intraassay precision: Hippuric Acid: 2.0 %, 52010 Mobile Phase 1000 ml Methylhip. Acids: 2.1 % 52011 Standard Solution 3 ml 52012 Internal Standard IS 10 ml Interassay precision: Hippuric Acid: 2.3 %, 9922 Urine Calibrator, lyophil. 5 x 5 ml Methylhip. Acids: 3.2 % 52320 Sample Preparation Columns 2 x 52320 (2 x 50 pcs.) 52021 Reagent A 400 ml 52022 Reagent B 2 x 52022 (2 x 400 ml) HPLC Parameters Manual 1 pce. Quick Reference 1 pce. Pump: isocratic pump, flow rate: 1.0 ml/min Start Accessories: Injection volume: 20 μl 52330 Analytical Column with test chromatogram 1 pce.

Injection interval: 8 min Accessories: UV-Detector: 230 nm FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. HPLC-Thermostat: 30 °C FK5821 Replacement filter for stainless steel prefilter holder 10 pcs.

Sample Preparation ClinChek® Controls: 8922 Urine Control, lyophil., Level I, II 2 x 5 x 5 ml Dilution:

100 μl Internal 100 μl urine 2 ml Reagent B ➜ Standard IS Sample clean-up via SPE ➜ Extraction:

Transfer the whole sample to a conditioned ➜ sample preparation column Injection interval: 8 min ➜ wash (2 x 2 ml Reagent B) Elution:

Elute with 2 ml Reagent A ➜ High analytical sensitivity ➜ collect the eluate HPLC Analysis:

Inject 20 μl

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t,t-Muconic acid is a minor metabolite of benzene Benzene and Derivatives ClinChek® Urine Control, Level I: ClinChek® Urine Control, Level II: and serves for the assessment of an occupational

benzene exposure. In contrast to phenol (see pages 100 100 96 - 97), t,t-muconic acid is not a physiological t,t-Muconic Acid com po nent of urine and thus provides a higher diagnos tic specificity. This ClinTox® Com plete Kit 50 50 7.15 in Urine 7.15 represents a robust and sensitive method with a 5.75 5.83 Intensity (mV) Intensity (mV) HBM highly selective sample preparation, followed by 0 0 isocratic separation with UV detection. Test Data -11 -11 0246 8 0246 8 Linearity: 0.24 - 20 mg/l

Recovery: 75 - 80 % Retention Time (min) Retention Time (min) LOD: 0.07 mg/l LLOQ: 0.24 mg/l t,t-Muconic acid: 5.83 min, IS: 7.15 min t,t-Muconic acid: 5.75 min, IS: 7.15 min Intraassay precision: 5.9 % Interassay precision: 5.5 % Ordering Information Order No. Description Quantity

HPLC Parameters 51000 ClinTox® Complete Kit for t,t-Muconic Acid in Urine for 100 assays 1 pce. Pump: gradient pump, Kit Components (order no. 51000): flow rate: 1.0 ml/min 51008 Mobile Phase A 2 x 51008 (2 x 1000 ml) Injection volume: 50 μl 51009 Mobile Phase B 800 ml 51011 Standard Solution 3 ml Injection interval: 18 min 51012 Internal Standard IS 15 ml UV-Detector: 264 nm 9922 Urine Calibrator, lyophil. 5 x 5 ml HPLC-Thermostat: 45 °C 51020 Sample Preparation Columns 2 x 51020 (2 x 50 pcs.) 51021 Reagent A 300 ml 51022 Reagent B 400 ml Sample Preparation 51023 Reagent C 300 ml 51024 Reagent D 300 ml Dilution: Manual 1 pce. 150 μl Internal Quick Reference 1 pce. 1 ml urine 1 ml Reagent B Standard IS Start Accessories: ➜ 51030 Analytical Column with test chromatogram 1 pce. Extraction:

Transfer the whole sample to a conditioned Accessories: sample preparation column FK5810 PEEK tubing (connection of prefilter and column) 1 pce. FK5820 Stainless steel prefilter holder 1 pce. ➜ wash (2 x 1.5 ml Reagent C) FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. Elution: ClinChek® Controls: Elute with 2 x 1.5 ml Reagent D 8922 Urine Control, lyophil., Level I, II 2 x 5 x 5 ml ➜ collect the eluates ➜ High diagnostic specificity HPLC Analysis: Inject 50 μl

➜ Highly selective sample preparation

➜ High analytical sensitivity

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ClinChek® Urine Control, Level I: ClinChek® Urine Control, Level II: Urinary 1-hydroxypyrene is used as a biological PAH Polycyclic Aromatic Hydrocarbons index for the assessment of an exposure to polycyclic aromatic hydrocarbons (PAH). Many indivi- 5 5

4 4 dual PAHs are genotoxic carcinogens and are for- 1-Hydroxypyrene 18.00 med by the incomplete combustion of fossil fuels. 3 3 The RECIPE ClinTox® Complete Kit is designed for 2 2 in Urine – 18.17 the automated determination of urinary 1-hydroxy- 1 1 Intensity (mV) Intensity (mV) pyrene in order to estimate an environmental or on-line Analysis 0 0 HBM

occu pational related PAH exposure. The sample pre - 1 1 paration is performed on-line by column switching 10 12 14 16 18 20 22 24 10 12 14 16 18 20 22 24 Test Data using a highly selective SPE-column (SPE: solid Retention Time (min) Retention Time (min) Linearity: 100 - 24000 ng/l phase extraction). Recovery: 100 % 1-Hydroxypyrene: 18.17 min 1-Hydroxypyrene: 18.00 min LOD: 20 ng/l LLOQ: 100 ng/l Ordering Information Intraassay precision: 2.6 % Order No. Description Quantity Interassay precision: 2.9 % 50000 ClinTox® Complete Kit for 1-Hydroxypyrene in Urine for 100 assays 1 pce.

HPLC Parameters Kit Components (order no. 50000): 50007 Mobile Phase A 1500 ml Pump 1: gradient pump, 50008 Mobile Phase B 2 x 50008 (2 x 2000 ml) flow rates: 1.0, 1.5 ml/min 50009 SPE-Buffer 2 x 50009 (2 x 2500 ml) 9925 Urine Calibrator, lyophil. 5 x 5 ml Pump 2: isocratic pump: 1.0 ml/min 50021 Stabilising Reagent S 200 ml Switching valve: 6-port/3-channel 50022 Enzyme Solution 1 ml (order no. FK1103) Manual 1 pce. Quick Reference 1 pce. Injection volume: 250 μl Injection interval: 36 min Start Accessories: 50030 Analytical Column with test chromatogram 1 pce. Fluorescence FK7000 manu-CART® cartridge holder, one time accessory 1 set detector: 242 nm (exc.), 388 nm (em.) 50031 SPE-Column 1 pce. HPLC-Thermostat: 30 °C 50032 Guard Column 5 pcs.

Accessories: Sample Pretreatment 50040 Vials for Sample Pretreatment with Screw Cap, 10 ml 100 pcs. FK5810 PEEK-tubing (connection of prefilter and column) 1 pce. Enzymatic hydrolysis: FK5820 Stainless steel prefilter holder 1 pce. 1 ml Stabilising 10 μl Enzyme FK5821 Replacement filter for stainless steel prefilter holder 10 pcs. 2 ml urine Reagent S Solution ®

➜ ClinChek Controls: 1. incubate (37 °C, 2 - 36 h) 2. centrifuge 8925 Urine Control, lyophil., Level I, II 2 x 5 x 5 ml on-line Analysis:

➜ Fully automated method Inject 250 μl

➜ Recovery 100 %

➜ High analytical sensitivity

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Photometric Complete Kits

ClinEasy® Photometric Complete Kits

ClinEasy® Complete Kits are designed for the diagnostic screening of urine specimen with photometric detectors.

Our kits are based on simple to use test procedu- res with manual SPE (SPE: solid phase extraction). A complete kit contains all reagents required for sample preparation and subsequent photometric detection. Urine calibrators and controls as well as accessories (e.g. SPE column rack, reagent tubes) are provided separately.

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Photometric Complete Kits

ClinEasy® Photometric Complete Kits

Porphyria, Lead Intoxication 5-ALA / PBG in Urine ...... 108 - 109 PBG in Urine ...... 110 - 111 Total Porphyrins in Urine ...... 112 - 113

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This ClinEasy® Complete Kit is designed for the Porphyria, Lead Intoxication photo metric determination of urinary 5-aminolevulinic acid (5-ALA) and porphobilinogen (PBG). Enhanced levels of 5-ALA and PBG are observed 5-Aminolevulinic Acid / with porphyrias and in case of certain intoxications (lead). The sample preparation is performed by Porphobilinogen in combination of special SPE columns for 5-ALA and PBG. In case only PBG shall be determined, a Urine separate ClinEasy® Complete Kit is available (see pages 110 - 111). For diagnostic verification a Test Data ClinEasy® Complete Kit for the total porphyrins Linearity: 0.8 - 80 mg/l (see pages 112 - 113) and a ClinRep® HPLC Recovery: > 90 % Complete Kit for the differentiated porphyrins (see

LOD: 0.6 mg/l Photometry pages 50 - 51) are additionally provided. LLOQ: 0.8 mg/l Intraassay precision: 5-ALA: 3.4 % PBG: 5.2 % Interassay precision: 5-ALA: 4.6 % PBG: 6.4 % Sample Preparation Extraction:

Apply 0.5 ml urine to a conditioned 5-ALA / PBG double column ➜ wash (3 x 10 ml HPLC water) Ordering Information Order No. Description Quantity Separate the double column Colourless column: ➜ A: Sample Preparation for 5-ALA 17200 ClinRep® Complete Kit for 5-Aminolevulinic Acid and Porphobilinogen in Urine 1 pce. Blue column: ➜ B: Sample Preparation for PBG for 50 assays A: Sample Preparation for 5-ALA Kit Components (order no 17200): Elution: 17220 Sample Preparation Columns for 5-ALA 50 pcs. 17320 Sample Preparation Columns for PBG 50 pcs. Elute with 7.0 ml Reagent A (receiver tube: 500 μl Reagent B) 17221 Reagent A 500 ml 17222 Reagent B 50 ml ➜➜ collect the eluate 17223 Reagent C 2 x 17223 (2 x 7.5 g) Derivatisation: 17224 Reagent D 200 ml 1. Incubate at 100 °C (water bath, 10 min) Manual 1 pce. 2. Add 7.0 ml Ehrlichʼs Reagent Quick Reference 1 pce. 3. Incubate at room temperature (15 min) 17300 ClinRep® Complete Kit for Porphobilinogen in Urine 1 pce. for 50 assays ➜ Cost-efficient screening Analysis: Kit Components (order no 17300): Photometric measurement 17320 Sample Preparation Columns for PBG 50 pcs. 17223 Reagent C 7.5 g B: Sample Preparation for PBG 17224 Reagent D 200 ml ➜ Easy handling Elution: Manual 1 pce. Quick Reference 1 pce. Elute with 4.0 ml Reagent D Accessories:

➜➜ 17260 Column Rack (for 20 columns) 1 pce. collect the eluate ➜ Reliable test results Derivatisation: FK6300 Reagent tube (100 x 16 mm) with screw cap and o-ring, PP, autoclavable up to 121 °C 50 pcs.

1. Add 4.0 ml Ehrlichʼs Reagent ClinCal® Calibrator: 2. Incubate at room temperature (15 min) 17213 Urine Calibrator, lyophil. 5 x 5 ml

® Analysis: ClinChek Controls: 17280 Urine Control, lyophil., Level I 10 x 5 ml 17281 Urine Control, lyophil., Level II 10 x 5 ml Photometric measurement 17282 Urine Control, lyophil., Level I, II 2 x 5 x 5 ml

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This ClinEasy® Complete Kit is designed for the pho - Porphyria, Lead Intoxication to metric determination of urinary porphobilinogen (PBG). Enhanced levels of PBG are observed with porphyrias and in case of certain intoxications (lead). Porphobilinogen in For diagnostic verification additional ClinEasy® Complete Kits for 5-aminolevulinic acid and PBG Urine (see pages 108 - 109) and the total porphyrins (see pages 112 - 113) as well as a ClinRep® HPLC Complete Kit for the differentiated porphyrins (see Test Data pages 50 - 51) are provided. Linearity: 0.8 - 80 mg/l Recovery: > 90 % LOD: 0.6 mg/l LLOQ: 0.8 mg/l

Intraassay precision: 5.2 % PhotometryPhotometry Interassay precision: 6.4 %

Sample Preparation Extraction:

Apply 0.5 ml urine to a conditioned PBG column ➜ wash (3 x 10 ml HPLC water) Elution: Ordering Information

Elute with 4.0 ml Reagent D Order No. Description Quantity

® ➜➜ 17300 ClinRep Complete Kit for Porphobilinogen in Urine for 50 assays 1 pce. collect the eluate Derivatisation: Kit Components (order no 17300): 1. Add 4.0 ml Ehrlichʼs Reagent 17320 Sample Preparation Columns for PBG 50 pcs. 2. Incubate at ambient temperature (15 min) 17223 Reagent C 7.5 g 17224 Reagent D 200 ml Analysis: Manual 1 pce. Quick Reference 1 pce. Photometric measurement Accessories: FK4000 Column Rack (for 20 columns) 1 pce.

ClinCal® Calibrator: 17213 Urine Calibrator, lyophil. 5 x 5 ml

ClinChek® Controls: 17280 Urine Control, lyophil., Level I 10 x 5 ml 17281 Urine Control, lyophil., Level II 10 x 5 ml ➜ Cost-efficient screening 17282 Urine Control, lyophil., Level I, II 2 x 5 x 5 ml

➜ Easy handling

➜ Reliable test results

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This ClinEasy® Complete Kit is designed for the Porphyria, Lead Intoxication photometric determination of the total porphyrins in the diagnosis of porphyrias. In contrast to the HPLC determination of the differentiated por- Total Porphyrins phyrins (see pages 50 - 51), the total porphyrin concentration is quan ti fied by a photospectrometer in Urine after elution of the urine sample from a sample preparation column. The test is cost-efficient and can be performed quickly and easily. For diagnostic Test Data verification additional ClinEasy® Complete Kits for Linearity: 20 - 4000 μg/l 5-aminolevulinic acid and porphobilinogen (see Recovery: ~ 70 % pages 108 - 109) as well as for porphobilinogen LOD: 15 μg/l (see pages 110 - 111) are provided. LLOQ: 20 μg/l

Intraassay precision: 5.5 % Photometry Interassay precision: 7.2 %

Sample Preparation Extraction:

Apply 1.0 ml urine to a conditioned sample preparation column ➜ wash (10 ml HPLC water) Elution: Ordering Information Order No. Description Quantity Elute with 2.0 ml Eluting Reagent E

➜ 17100 ClinRep Complete Kit for Porphyrins in Urine for 50 assays 1 pce. collect the eluate Analysis: Kit Components (order no. 17100): 17120 Sample Preparation Columns 50 pcs. Photometric measurement 17121 Eluting Reagent E 200 ml Manual 1 pce. Quick Reference 1 pce.

Accessories: FK4000 Column Rack (for 20 columns) 1 pce.

ClinChek® Controls: 17280 Urine Control, lyophil., Level I 10 x 5 ml 17281 Urine Control, lyophil., Level II 10 x 5 ml 17282 Urine Control, lyophil., Level I, II 2 x 5 x 5 ml

➜ Cost-efficient screening

➜ Easy handling

➜ Reliable test results

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LC-MS/MS Complete Kits

ClinMass® Diagnostics LC-MS/MS ClinMass® Therapeutic Drug Monitoring

ClinSpot® Dried Blood Spot Analysis

ClinMass® LC-MS/MS Complete Kits are intended for diagnosis and therapeutic drug monitoring (TDM) in clinical, toxicological and forensic laboratories. ClinSpot® LC-MS/MS Complete Kits are designed for the analysis of dried blood spot (DBS) specimens in neonatal screening.

ClinMass® TDM Kit System / ClinMass® TDM Kit System, on-line Additionally to complete kits, a novel kit system is provided for TDM. It is based on a universal ClinMass® TDM platform that can be used for the analysis of currently 102 different drugs and metabolites. The ClinMass® TDM Kit System is available both for the standard LC-MS/MS configuration as well as for on-line SPE analysis (TDM Kit Sys - tem, on-line).

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LC-MS/MS Complete Kits

ClinMass® Diagnostics

for clinical, toxicological and forensic analysis Diagnostics

Alcoholism Ethylglucuronide and Ethylsulfate in Urine, Plasma and Serum ...... 118 - 119 Biogenic Amines Free Metanephrines in Plasma – on-line Analysis ...... 120 - 121 Metabolic Diseases Homocysteine in Plasma / Serum . . 122 - 123 Vitamin Status Methylmalonic Acid in Serum / Plasma / Urine, advanced ...... 124 - 125 25-OH Vitamin D2 / D3 in Plasma and Serum – on-line Analysis ...... 126 - 127 – Automated on-line Analysis ...... 126 - 127

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Ethylglucuronide (EtG) and ethylsulfate (EtS) are Alcoholism Chromatogram of the ClinChek® Urine Control, Level II (order no. MS8081): known as relatively new, specific parameters for the assessment of alcohol consumption, which dates 3300 1.6e5 3200 2.11 d5-EtG 4.05 d5-EtS back several days. The analysis is primarily perfor- 1.5e5 3000 m/z: 226.1 74.8 m/z: 129.9 97.8 Ethylglucuronide and 1.4e5 med from urine but may be extended to plasma and 2800 2600 1.3e5 ® serum. For this purpose RECIPE offers a ClinMass Ethylsulfate in Urine, 2400 1.2e5 2200 1.1e5 Complete Kit for analysis from urine, which can be 2000 1.0e5 9.0e4 ® Plasma and Serum 1800 expanded to plasma and serum samples (ClinMass 1600 2.14 EtG 8.0e4

Supplement Kit, order no. MS8100). The analytical 1400 m/z: 220.9 74.8 7.0e4 1200 6.0e4 1000 5.0e4 method features fast and simple sample preparation Intensity (cps) Intensity (cps) Test Data (Urine) 800 4.0e4 and guarantees a reliable analyte determination. 600 3.0e4 Linearity: EtG: 76.2 - 100000 μg/l 400 2.0e4 4.10 EtS The kit validation was established in compliance 200 1.0e4 m/z: 124.8 96.8 EtS: 21.8 - 76356 μg/l 0.0 0.0 with the German GTFCh guidelines for quality LOD: EtG: 45.7 μg/l / EtS: 13.1 μg/l 1.9 2.4 3.8 4.5 assurance. LLOQ: EtG: 76.2 μg/l / EtS: 21.8 μg/l Intraassay precision: EtG: 5.3 % / EtS: 4.6 % Retention Time (min) Retention Time (min) Interassay precision: EtG: 5.4 % / EtS: 4.9 %

Ordering Information LC-MS/MS Parameters Order No. Description Quantity LC-Parameters

HPLC pump: isocratic, flow rates: MS8000 ClinMass® Complete Kit for Ethylglucuronide and Ethylsulfate in Urine 1 pce. 0.2 ml/min, 0.5 ml/min for 400 assays

Injection volume: 10 μl Kit Components (order no. MS8000): Diagnostics Injection interval: 5 min MS8005 Autosampler Washing Solution 1000 ml MS8010 Mobile Phase 1000 ml Column heater: 40 °C MS8012 Internal Standard IS 4 x MS8012 (4 x 100 ml) MS-Parameters MS8713 Urine Calibrator Set, lyophil., Level 0 - 6 7 x 1 x 1 ml Ion source: ESI, negative Manual 1 pce.

MS/MS-Mode: MRM MS8100 ClinMass® Supplement Kit for Ethylglucuronide and Ethylsulfate in Plasma and Serum 1 pce. for 100 assays

Sample Preparation Kit Components (order no. MS8100): A: Urine MS8112 Internal Standard IS 30 ml Dilution: MS8113 Serum Calibrator Set, lyophil., Level 0 - 3 4 x 1 x 1 ml MS8121 Diluting Solution D 50 ml 50 μl urine 1000 μl (calibrator, control, patient) Internal Standard IS Additional Components:

➜ MS8014 Optimisation Mix 2 ml LC-MS/MS Analysis: MS8413 Urine Calibrator Set, lyophil., Level 0 - 3 4 x 1 x 1 ml

Inject 10 μl Start Accessories: ➜ Fast and simple MS8030 Analytical Column with test chromatogram 1 pce. B: Plasma / Serum sample preparation ClinChek® Controls: Precipitation: MS8080 Urine Control, lyophil., Level I 10 x 1 ml MS8081 Urine Control, lyophil., Level II 10 x 1 ml 100 μl sample 300 μl MS8082 Urine Control, lyophil., Level III 10 x 1 ml (calibrator, control, patient) Internal Standard IS MS8083 Urine Control, lyophil., Level I, II, III 3 x 3 x 1 ml ➜ ➜ Method validation mix, centrifuge MS8180 Serum Control, lyophil., Level I 10 x 1 ml Dilution: MS8181 Serum Control, lyophil., Level II 10 x 1 ml according to 50 μl 500 μl MS8182 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml GTFCh guidelines supernatant Diluting Solution D ➜

LC-MS/MS Analysis:

Inject 10 μl

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Plasma free metanephrines (PFM) are the most spe - Biogenic Amines Chromatogram of the ClinCal® Serum Calibrator, level 2 (order no. MS11013) cific parameters for the diagnosis of extraadrenal chromaffin tumors. The measurement of PFMs (me - tan ephrine (M), normetanephrine (NM) and 3-meth - 100 Free Metanephrines 3-Methoxytyramine oxytyramine (MT)) is challenging because of their 108 pmol/L polar nature, their low molecular weight and their in Plasma – on-line 0 low physiological concentration in human plasma. 100 Analysis Metanephrine Most LC-MS/MS methods used in clinical routine 140 pmol/L

ana lysis involve time- and labour-consuming ma nual 0

sample preparation for solid phase extraction (SPE). Intensity (%) 100 ® Test Data In contrast to this, the RECIPE ClinMass Com plete Normetanephrine Linearity (up to): 5200 ng/l (M), 196 pmol/L Kit represents the first commercially avail able CE-IVD 10000 ng/l (NM, MT) method and provides a simple sample pretreat- 0 Recovery: 83 - 116 % 1.00 2.00 3.00 4.00 5.00 ment with one-step protein precipitation and sub- LOD: 1.94 ng/l (M), 3.67 ng/l (NM), sequent on-line SPE. 0.94 ng/l (MT) Retention Time (min) LLOQ: 5.82 ng/l (M), 11.0 ng/l (NM), 2.83 ng/l (MT) Ordering Information Intraassay precision: 3.1 % (M), 4.5 % (NM), Order No. Description Quantity 3.4 % (MT)

Interassay precision: 3.2 % (M), 4.7 % (NM), MS11000 ClinMass® Complete Kit for Free Metanephrines in Plasma – on-line Analysis 1 pce. 4.1 % (MT) for 200 assays

Contents (order no. MS11000): Diagnostics LC-MS/MS Parameters MS11005 Autosampler Washing Solution 1000 ml MS11007 Mobile Phase A 250 ml LC-Parameters MS11008 Mobile Phase B 2 x MS11008 (2 x 1000 ml) Pump 1: SPE-Buffer (0.1 - 1.0 ml/min) MS11009 SPE-Buffer Load L 2 x MS11009 (2 x 1000 ml) Pump 2: Mobile Phase A / B MS11010 SPE-Buffer Wash W 1000 ml MS11012 Precipitant P with Internal Standard 30 ml (0.6 ml/min) MS11013 Serum Calibrator Set, lyophil. (Level 0 - 4) 5 x 1 x 3 ml Injection volume: 50 μl MS11020 Sample Pretreatment Vials 2 x MS11020 (2 x 100 pcs.) Manual 1 pce. Injection interval: 6.0 min Switching valve: automatic switching valve, Additional Components: 6-port/3-channel MS11014 Optimisation Mix 2 ml

Column heater: 25 °C Start Accessories: MS-Parameters MS11030 Analytical Column with test chromatogram 1 pce. MS11031 SPE-Column 1 pce. Ion-Source: ESI, positive MS/MS-Mode: MRM ClinChek® Controls: MS11080 Serum Control, lyophil., Level I 10 x 3 ml ➜ First commercially MS11081 Serum Control, lyophil., Level II 10 x 3 ml Sample Pretreatment MS11082 Serum Control, lyophil., Level III 10 x 3 ml available CE-IVD kit 150 μl Precipitant P MS11083 Serum Control, lyophil., Level I, II, III 3 x 3 x 3 ml (contains IS) ➜ Highly sensitive and selective 1. Mix, incubate (ambient temp.) Inject LC-MS/MS method 100 μl Sample supernatant (on-line SPE) ➜ 2. Mix, centrifuge ➜ 5-level calibrator set, controls in 3 levels

➜ Isotope-labelled internal standard compunds

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Homocysteine is an established parameter for the Metabolic Diseases Chromatogram (left) and mass traces (right) of the ClinCal® Serum Calibrator, Level 3 (order no. MS2013) risk assessment of degenerative vascular diseases, which may lead to heart attack, stroke and throm- 0.74 0.74 ® 4.8e5 bosis. The RECIPE ClinMass Complete Kit allows 4.6e5 4.0e5 Homocysteine 4.4e5 3.5e5 Homocysteine a reliable determination of total homocysteine for 4.2e5 3.0e5 4.0e5 m/z: 136.1 ➜ 90.1 3.8e5 2.5e5 the detection of hyperhomocysteinemia. After an in Plasma / Serum 3.6e5 2.0e5 3.4e5 1.5e5 easy sample preparation (reduction and precipita- 3.2e5 1.0e5 3.0e5 2.8e5 5.0e4 tion step) the samples are analysed with an injec- 2.6e5 0.00 2.4e5 Test Data 2.2e5 0.73 tion interval of 1.0 min only. 2.0e5 3.0e5 1.8e5 2.5e5 d4-Homocysteine Optionally, the sample preparation can be performed Linearity: 0.1 - 106 μmol/l Intensity (cps) 1.6e5 Intensity (cps) 1.4e5 2.0e5 m/z: 140.1 ➜ 94.1 LOD: 0.01 μmol/l 1.2e5 fully automated with liquid handling systems and 1.0e5 1.5e5 8.0e4 96-well plates. LLOQ: 0.1 μmol/l 6.0e4 1.0e5 4.0e4 5.0e4 2.0e4 Intraassay precision: 1.9 % 0.00 0.00 Interassay precision: 4.8 % 0.6 0.65 0.7 0.75 0.8 0.85 0.9 0.95 1.0 0.55 0.65 0.75 0.85 0.95

LC-MS/MS Parameters Retention Time (min) Retention Time (min) LC-Parameters Pump: isocratic (0.7 ml/min) Ordering Information Injection volume: 1 μl Order No. Description Injection interval: 1.0 min ® Column heater: room temperature MS2000 ClinMass Complete Kit for Homocysteine in Plasma / Serum 1 pce. for 300 assays

Kit Components (order no. MS2000):

MS-Parameters Diagnostics MS2005 Autosampler Washing Solution 1000 ml Ion source: ESI, positive MS2010 Mobile Phase 800 ml MS/MS-Mode: MRM MS2012 Internal Standard IS, lyophil. 3 x MS2012 (3 x 5 ml) MS2013 Serum Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 1 ml MS2020 Sample Preparation Vials 3 x MS2020 (3 x 100 pcs.) Sample Preparation MS2021 Reagent A 3 x MS2021 (3 x 5 ml) Reduction: MS2022 Reagent B 2 x MS2022 (2 x 30 ml) Manual 1 pce. 50 μl sample 50 μl Reagent A (+ 50 μl Internal Standard IS) Start Accessories:

➜ MS2030 Analytical Column with test chromatogram 1 pce. mix, incubate (room temperature, 5 min) Precipitation: Accessories: FK6500 Protective sheets for 96-well-plate (aluminium foil, 80 x 140 mm) 100 pcs. 200 μl Reagent B FK6510 96-Well-Plates (370 μl) 5 pcs. FK6511 96-Well-Plates (1200 μl) 5 pcs. ➜ 1. mix, incubate (4 °C, 5 min) ClinChek® Controls: 2. centrifuge LC-MS/MS Analysis: 23080 Plasma Control, lyophil., Level I 10 x 3 ml ➜ Simple and quick two-step 23081 Plasma Control, lyophil., Level II 10 x 3 ml Inject 1 μl of the supernatant 23082 Plasma Control, lyophil., Level I, II 2 x 5 x 3 ml sample preparation

➜ Injection interval: 1.0 min

➜ Optional: method with automated sample preparation (96-well plates)

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Methylmalonic acid (MMA) serves for the assess ment of Vitamin Status Chromatogram of the ClinChek® Serum Control, Level I (order no. MS5080) the vitamin B12 status. Vitamin B12 deficiency leads to an increased MMA concentration in serum, plasma and urine. 0.56 This new RECIPE ClinMass® Complete Kit provides a fast 1.02e4 1.00e4 Succinic Acid Methylmalonic Acid 9500.00 and time saving MMA analysis featu ring short sample 9000.00 8500.00 preparation with only one pipet ting step (serum, plas ma) 8000.00 in Serum / Plasma / 7500.00 or direct injection of samples after dilution and addition 7000.00 6500.00 of IS (urine). The subsequent LC-MS/MS analysis is per - 6000.00 Urine, advanced 5500.00 formed within a 2 min injection interval only while the iso - 5000.00 1.50 4500.00 d3-Methylmalonic Acid 4000.00 m/z: 119.9 ➜ 76 bar component succinic acid, which may interfere with 3500.00 Intensity (cps) 3000.00 Methylmalonic Acid MMA, is separated reliably. Calibra tion and quality con- Test Data 2500.00 m/z: 116.9 ➜ 73 2000.00 trol is per formed in a convenient and cost- efficient way. Linearity: 1500.00 1000.00 The method is fully validated using only one (se rum) cali - – Serum, Plasma: 25 - 67745 nmol/l 500.00 0.00 bration and control set for all three sample matrices – Urine: 651 - 1426200 nmol/l 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 (Clin Cal® 4-Level Cali brator Set and ClinChek® Controls). LOD: – Serum, Plasma: 15 nmol/l Retention Time (min) – Urine: 391 nmol/l LLOQ: Ordering Information – Serum, Plasma: 25 nmol/l Order No. Description Quantity – Urine: 651 nmol/l

Intraassay precision: 4.3 % MS5100 ClinMass® Complete Kit, advanced, for Methylmalonic Acid in Serum / Plasma / Urine 1 pce. Interassay precision: 5.1 % for 300 assays

Kit Components (order no. MS5100): Diagnostics LC-MS/MS Parameters MS5005 Autosampler Washing Solution 1000 ml MS5108 Mobile Phase A 1000 ml LC-Parameters MS5109 Mobile Phase B 200 ml Binary gradient pump: Mobile Phase A / B MS5112 Precipitant P with Internal Standard 3 x MS5112 (3 x 40 ml) (0.7 ml/min) MS5013 Serum Calibrator Set, lyophil., (Level 0 - 3) 4 x 1 x 2 ml MS5020 Sample Preparation Vials 3 x MS5020 (3 x 100 pcs.) Injection volume: 2 - 5 μl Manual 1 pce. Injection interval: 2.0 min Additional Components: Column heater: 25 °C MS5114 Optimisation Mix 2 ml MS-Parameters MS5021 Diluting Solution D for Urine 50 ml Ion source: Turbo-ionspray (TIS) ESI, Start Accessories: negative MS5130 Analytical Column with test chromatogram 1 pce. MS/MS-Mode: MRM ClinChek® Controls: MS5080 Serum Control, lyophil., Level I 10 x 2 ml Sample Preparation MS5081 Serum Control, lyophil., Level II 10 x 2 ml MS5082 Serum Control, lyophil., Level I, II 2 x 5 x 2 ml ➜ One-step sample pre- Precipitation / Addition of IS: 400 μl P Precipitant 100 μl sample* paration (serum / plasma) (contains internal standard) (calibrator, control, patient) ➜ mix and centrifuge LC-MS/MS Analysis: ➜ Reliable separation Inject 2 - 5 μl of the sample

of succinic acid * Urines are diluted (50 μl urine + 1000 μl Diluting Solution D)

➜ Injection interval: 2 min

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The ClinMass® Complete Kits with order nos. MS7000 Vitamin Status and MS7100 enable a fast on-line SPE LC-MS/MS 25-OH-Vit D2 25-OH-Vit D3 d6-25-OH-Vit D3 2.65 analysis of 25-OH-Vitamin D (D2, D3) with an injection 2.69 2.65 2895 3000 8000 100 MS7030 interval of 3 min only. The sample pretreatment can 25-OH Vitamin D2 / D3 2500 7000 Vit D3 be performed manually (MS7000) or automated with 2500 6000 3-epi Vit D3 liquid handling systems of several device manufactu- 2000 in Plasma and Serum 2000 5000 rers (MS7100). The C-3 epimer of 25-OH vitamin D3 0 2.5 3.0 (3-epi-25-OH vitamin D3) is separated reliably from – on-line Analysis 1500 1500 4000 100 MS7035 Intensity (%)

the analyte peak. An analytical column with a run time Intensity (cps) 3000 1000 – automated on-line Analysis 1000 Vit D3 of 4 min (order no. MS7035) is additio nally avail able 2000 in order to obtain base line separation. 500 500 1000 3-epi Vit D3

Test Data 0 0 0 0 3.6 4.1 Linearity: 1.4 - 250 μg/l (D2) 2.5 3.0 2.5 3.0 2.5 3.0

2.3 - 250 μg/l (D3) Retention Time (min) Retention Time (min) LOD: 0.4 μg/l (D2) ® 0.7 μg/l (D3) left: ClinCal Serum Calibrator, order no. MS7013, level 2 (25-OH vitamin D2 and D3) and ClinMass® Internal Standard, order no. MS7012 (d6-25-OH vitamin D3) LLOQ: 1.4 μg/l (D2) right: Human serum with 25-OH vitamin D3 and 3-epi-25-OH vitamin D3, measured with the 2.3 μg/l (D3) 3-min method (top) and 4-min method (bottom) Intraassay precision: 6.8/3.9 % (D2) 4.7/3.3 % (D3) Ordering Information Interassay precision: 7.6/4.3 % (D2) Order No. Description Quantity 6.6/4.2 % (D3) ® MS7000 ClinMass Complete Kit for 25-OH Vitamin D2 / D3 in Plasma and Serum 1 pce. Diagnostics for 300 assays LC-MS/MS Parameters Kit Components (order no. MS7000): LC-Parameters MS7005 Autosampler Washing Solution 1000 ml MS7009 SPE-Buffer 2 x MS7009 (2 x 1000 ml) Pump 1: SPE-Buffer (0.1 - 5.0 ml/min) MS7010 Mobile Phase 700 ml Pump 2: Mobile Phase (0.5 ml/min) MS7012 Internal Standard IS 30 ml MS7013 Serum Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 1 ml Injection volume: 10 - 50 μl MS7020 Sample Pretreatment Vials 3 x MS7020 (3 x 100 pcs.) Injection interval: 3 min (4 min) MS7021 Precipitant P 15 ml Switching valve: 6-port/3-channel Manual 1 pce.

(order no. FK1102) MS7100 ClinMass® Complete Kit for 25-OH Vitamin D2 / D3 in Plasma and Serum 1 pce. Column heater: 40 °C for 1200 assays Kit Components (order no. MS7100): MS-Parameters 4-fold amount of kit components with order no. MS7000 (MS7005, … , MS7021) 4 x MS7000* Ion source: Heated Nebulizer (APcI), - without MS7020 (but with FK6513 instead)* positive FK6513 96-Well-Plates (600 μl) 3 x FK6513 (3 x 5 pcs.) Manual 1 pce. MS/MS-Mode: MRM ➜ Fast on-line analysis Additional Components: MS7014 Optimisation Mix 2 ml (injection interval: 3 min) Sample Pretreatment MS7015 Optimisation Mix 3-epi 1 ml Precipitation: Start Accessories: MS7030 Analytical Column with test chromatogram 1 pce. 150 μl 50 μl sample MS7035 Analytical Column 3-epi with test chromatogram 1 pce. ➜ mixture IS/P (calibrator, control, patient) (for the additional analysis of 3-epi-25-OH Vitamin D3) Separation of the ➜ MS7031 SPE-Column 1 pce. 1. mix, incubate (4 °C) Accessories: 2. mix, centrifuge C-3 epimer on-line Analysis: FK6501 Protective Sheets for 96-Well-Plates (PE/PP foil, 80 x 140 mm) 50 pcs. FK6514 96-Well Plates (300 μl) 5 pcs. Inject 10 - 50 μl FK7340 Sealings and sieves for order no. FK7400 4 pcs. each FK7400 Inline-Filter (stainless steel sieve, free of dead volume) 1 pce. ➜ ClinChek® Controls: Traceable to NIST MS7080 Serum Control, lyophil., Level I 10 x 1 ml standard SRM 972a MS7081 Serum Control, lyophil., Level II 10 x 1 ml MS7082 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml

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LC-MS/MS Complete Kits

ClinMass® TDM for Therapeutic Drug Monitoring

Immunosuppressants Immunosuppressants in Whole Blood, advanced – on-line Analysis ...... 130 - 131 TDM – Automated on-line Analysis ...... 130 - 131

TDM Kit System

Add-on Sets for TDM Platform . . . . . 132 - 133 Benzodiazepines (BZP) ...... 134 - 135 Tricyclic Antidepressants (TCA) . . . . 136 - 137 Antiepileptic Drugs (AED) ...... 138 - 139 Antidepressants (ADP) ...... 140 - 141

TDM Kit System, on-line

Add-on Sets for TDM Platform, on-line ...... 142 - 143 Benzodiazepines (BZP) ...... 144 - 145 Tricyclic Antidepressants (TCA) . . . . 146 - 147 Antiepileptic Drugs (AED) ...... 148 - 149 Antidepressants (ADP) ...... 150 - 151

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The ClinMass® Complete Kits with order nos. Immunosuppressants Chromatogram (left) and mass traces (right) of the ClinCal® Whole Blood Calibrator (order no. 9933), level 4 MS1100 and MS1200 enable a fast on-line SPE LC-MS/MS analysis of cyclosporine A, tacrolimus, 5.9e5 7.9e4 1.24 3.1e4 1.29 sirolimus and everolimus with an injection interval 7.0e4 2.8e4 5.5e5 Tacrolimus Sirolimus Immunosuppressants 6.0e4 2.4e4 13 13Cd -Tacrolimus Cd3-Sirolimus of 2 min only. The sample pretreatment can be per- 5.0e5 5.0e4 2 2.0e4 4.0e4 m/z: 1.6e4 m/z: formed manually (MS1100) or automated with 4.5e5 ➜ in Whole Blood, advanced 3.0e4 821.5 ➜ 768.4 1.2e4 931.5 864.5 935.6 ➜ 864.7 liquid handling systems of several device manu- 4.0e5 2.0e4 824.5 ➜ 771.5 8000.0 3.5e5 1.0e4 4000.0 – on-line Analysis 0.0 0.0 facturers (MS1200). 3.0e5 3.0e4 5.9e5 2.5e5 2.8e4 1.30 1.42 5.0e5 – automated on-line Analysis 2.4e4 Everolimus Cyclosporine A 2.0e5 13 d12-Cyclosporine A Intensity (cps) Intensity (cps) 2.0e4 C2d4-Everolimus 4.0e5 1.5e5 1.6e4 m/z: 3.0e5 m/z: 1.2e4 1219.7 ➜ 1202.9 1.0e5 975.5 ➜ 908.4 2.0e5 8000.0 981.6 ➜ 914.7 1232.0 ➜ 1215.0 5.0e4 Test Data 4000.0 1.0e5 Linearity (up to): 0.0 0.0 0.0 1.0 1.2 1.4 1.6 1.8 0.2 0.6 1.0 1.4 1.8 0.2 0.6 1.0 1.4 1.8 1750 μg/l (Cyc), 72 μg/l (Tcr, Srl, Evr)

LOD: Retention Time (min) Retention Time (min) 0.011 μg/l (Cyc), 0.004 μg/l (Tcr), 0.073 μg/l (Srl), 0.126 μg/l (Evr) Ordering Information LLOQ: Order No. Description Quantity 0.037 μg/l (Cyc), 0.014 μg/l (Tcr), MS1100 ClinMass® Complete Kit, advanced, for Immunosuppressants in Whole Blood 1 pce. 0.244 μg/l (Srl), 0.420 μg/l (Evr) for 400 assays Intraassay precision: Kit Components (order no. MS1100): 2.5 % (Cyc), 4.6 % (Tcr), 4.8 % (Srl), 4.9 % (Evr) MS1005 Autosampler Washing Solution 1000 ml MS1009 SPE-Buffer 2 x MS1009 (2 x 1000 ml) Interassay precision: MS1010 Mobile Phase 800 ml 6.5 % (Cyc), 4.2 % (Tcr), 4.4 % (Srl), 4.3 % (Evr) MS1412 Internal Standard IS, lyophil. 3 x MS1412 (3 x 3 ml) MS1020 Sample Pretreatment Vials 4 x MS1020 (4 x 100 pcs.)

MS1021 Precipitant P 80 ml TDM LC-MS/MS Parameters Manual 1 pce. LC-Parameters MS1200 ClinMass® Complete Kit, advanced, for Immunosuppressants in Whole Blood 1 pce. Pump 1: SPE-Buffer (0.1 / 2.5 ml/min) for 1200 assays Pump 2: Mobile Phase (0.5 / 1.0 ml/min) Kit Components (order no. MS1200): 3-fold amount of kit components with order no. MS1100 (MS1005, … , MS1021) 3 x MS1100* Injection volume: 20 - 50 μl - without MS1020 (but with FK6511 instead)* Injection interval: 2 min FK6511 96-Well-Plates (1200 μl) 3 x FK6511 (3 x 5 pcs.) Switching valve: 6-port/3-channel Manual 1 pce.

(order no. FK1102) Additional Components: Column heater: 60 °C MS1006 Reagent MP 8 ml MS1014 Optimisation Mix 1, lyophil. 2 ml MS-Parameters MS1115 Optimisation Mix 2, lyophil. 2 ml Ion source: ESI, positive 9028 Whole Blood Calibrator, lyophil. (additional level for order nos. 9033 and 9933) 2 x 2 ml ➜ Fast on-line analysis MS/MS-Mode: MRM 9033 Whole Blood Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 2 ml 9933 Whole Blood Calibrator Set, lyophil. (Level 0 - 6) 7 x 1 x 2 ml (injection interval: 2 min) Start Accessories: Sample Pretreatment MS1030 Analytical Column with test chromatogram 1 pce. MS1031 SPE-Column 1 pce. Precipitation: MS1032 Guard Column Holder incl. 1 Guard Column 1 pce. 100 μl whole blood MS1033 Guard Column 5 pcs. ➜ 200 μl 20 μl Internal No matrix effects (calibrator, control, Accessories: Precipitant P Standard IS patient) FK6501 Protective Sheets for 96-Well-Plates (PE/PP foil, 80 x 140 mm) 50 pcs. FK6514 96-Well Plates (300 μl) 5 pcs. ➜ 1. mix and incubate FK7400 Inline-Filter (stainless steel sieve, free of dead volume) 1 pce. (ambient temperature) FK7340 Sealings and sieves for order no. FK7400 4 pcs. each ➜ ClinChek® Controls: 4- and 7-Level calibrator on-line Analysis: 2. mix and centrifuge 8830 Whole Blood Control, lyophil., Level I 5 x 2 ml set available 8831 Whole Blood Control, lyophil., Level II 5 x 2 ml Inject 20 - 50 μl of the supernatant 8832 Whole Blood Control, lyophil., Level III 5 x 2 ml 8833 Whole Blood Control, lyophil., Level I, II, III 3 x 2 x 2 ml 8903 Whole Blood Control, lyophil., Level IV, V 2 x 2 x 2 ml

131 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:15 Seite 132 Neuroleptics (NLP), Antimycotics (AMC), Cytostatics (CYT) Additional ClinMass TDM Kit System ® Add-on Sets in preparation: One-step sample preparation! mobile phases) and on one TDM Platform (i.e. identical sample preparation and The ClinMass Add-on Sets for TDM Platform ClinMass Complete Kits LC-MS/MS The whole analyte panel is determined on one The benefits: ClinMass Select your analyte panel by choosing the suitable be used for several different TDM analytes. versal TDM Platform (order no. MS9000) that can

ADP AED TCA BZP AP,see pages 140 - 141 (ADP), Add-on Set for 27 Ant see pages 138 - 139 (AED), Add-on Set for 26 Antiepileptic Drugs (TCA), see pages 136 - 137 Add-on Set for 14 Tricyclic Antidepressants (BZP), see pages 134 - 135 Add-on Set for 35 Benzodiazepines ® Add-on Sets. Currently available are: ® TDM Kit System is based on a uni- ® TDM Kit System analytical column. idepressants

133

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Benzodiazepines (BZP) are a group of psychoactive TDM Kit System Chromatogram of the ClinCal® Serum Calibrator, Level 2 (order no. MS6013) drugs with a broad range of therapeutic effects and belong to the most frequently prescribed drugs all over the world. Benzodiazepines 7-Aminonitrazepam 1.24 Chlordiazepoxide 3.55 The ClinMass® Add-on Set for Benzodiazepines (order 7-Aminoclonazepam 1.30 Alprazolam 3.67 3-Hydroxybromazepam 1.50 α-OH-Midazolam 3.90 no. MS9500) contains all analyte specific components in Serum / Plasma 6.4 7-Aminoflunitrazepam 1.51 Triazolam 3.93 5.6 Bromazepam 2.02 Desalkylflurazepam 4.12 required for the quantification of 35 different drugs Demoxepam 2.19 Flunitrazepam 4.13 4.8 Zopiclon 2.26 Temazepam 4.24 and metabolites. 4.0 Zaleplon 2.52 Nordiazepam 4.37 α-OH-Triazolam 2.74 Clobazam 4.48 ® 3.2 The ClinMass TDM Platform (order no. MS9000) con - Test Data α-OH-Alprazolam 2.75 Lormetazepam 4.61 2.4 Desmethylflunitrazepam 2.89 Trazodone 4.73

Test data are available on request. Intensity (cps) tains the components needed for sample preparation 1.6 Oxazepam 3.00 Flurazepam 4.79 Nitrazepam 3.06 Midazolam 4.99 0.8 and LC-MS/MS analysis. It can be used with all Estazolam 3.11 Diazepam 5.14 0.0 ClinMass® Add-on Sets of the TDM Kit System (BZP, LC-MS/MS Parameters Norclobazam 3.23 Tetrazepam 5.90 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.05.5 6.0 6.5 Lorazepam 3.37 Prazepam 6.23 TCA, …). The analytical column is suitable for the LC-Parameters Clonazepam 3.44 Medazepam 6.48 Zolpidem 3.50 whole analyte panel (102 compounds). Binary Gradient Pump: Mobile Phases A/B (0.6 ml/min) Retention Time (min) Injection volume: 1 - 10 μl* Injection interval: 6.8 min Ordering Information Column heater: 40 °C Order No. Description Quantity * depending on the sensitivity of the mass spectrometer ® MS-Parameters MS9000 ClinMass TDM Platform 1 pce. for 400 assays Ion source: ESI, positive MS/MS mode: MRM Components (order no. MS9000): MS9005 Autosampler Washing Solution 1000 ml MS9007 Mobile Phase A 2 x MS9007 (2 x 1000 ml) Sample Preparation MS9008 Mobile Phase B 1000 ml

MS9020 Sample Preparation Vials 4 x MS9020 (4 x 100 pcs.) TDM 100 μl Precipitant P MS9021 Precipitant P 2 x MS9021 (2 x 25 ml) (contains IS)* Start Accessories: MS9030 Analytical Column with test chromatogram 1 pce. MS9032 Prefilter 1 pce. 50 μl Sample Inject ➜ supernatant Accessories: mix, centrifuge MS9022 Diluting Solution D 50 ml

MS9500 ClinMass® Add-on Set for Benzodiazepines in Serum / Plasma 1 pce. One step for 200 assays ➜ Simple and time saving Components (order no. MS9500): sample preparation! MS9512 Internal Standard IS, lyophil. 5 x 5 ml sample preparation MS6013 Serum Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 1 ml Manual 1 pce.

* Reconstitution of IS (order no. MS9512) with 5 ml Precipitant P Start Accessories: (order no. MS9021) MS6015 - Optimisation Mix 1 - 5, lyophil. 2 ml each ➜ Flexible and fast LC-MS/MS MS6019 ClinChek® Controls: Analysis (6.8 min) MS6082 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml

➜ IS contains 20 isotope labeled analytes

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Tricyclic antidepressants (TCA) are a group of TDM Kit System Chromatogram of the ClinCal® Serum Calibrator, Level 2 (order no. MS9113) psycho active drugs which are mainly used for the therapy of endogene depressions, anxiety and pain management. Tricyclic Antidepressants The ClinMass® Add-on Set for TCAs (order no. MS9100) 8.0 Norclozapine 1.28 contains all analyte specific components required for in Serum / Plasma 7.2 Nordoxepin 1.31 6.4 Desipramine 1.65 the quantification of 12 TCAs and two atypical neuro- 5.6 Protriptyline 1.65 Doxepin 1.66 4.8 leptics. Maprotiline 1.76 4.0 Nortriptyline 1.76 ® Test Data The ClinMass TDM Platform (order no. MS9000) con - 3.2 Nortrimipramine 1.82 2.4 Imipramine 1.89 tains the components needed for sample preparation Test data are available on request. Intensity (cps) 1.6 Clozapine 2.00 and LC-MS/MS analysis. It can be used with all 0.8 Norclomipramine 2.02 Amitriptyline 2.11 0.0 ClinMass® Add-on Sets of the TDM Kit System (BZP, LC-MS/MS Parameters Trimipramine 2.35 1.2 1.4 1.6 1.8 2.0 2.2 2.4 2.6 Clomipramine 2.48 TCA, …). The analytical column is suitable for the LC-Parameters whole analyte panel (102 compounds). Binary Gradient Pump: Mobile Phases A/B (0.8 ml/min) Retention Time (min) Injection volume: 1 - 10 μl* Injection interval: 2.8 min Ordering Information Column heater: 40 °C Order No. Description Quantity * depending on the sensitivity of the mass spectrometer ® MS-Parameters MS9000 ClinMass TDM Platform 1 pce. for 400 assays Ion source: ESI, positive MS/MS mode: MRM Components (order no. MS9000): MS9005 Autosampler Washing Solution 1000 ml MS9007 Mobile Phase A 2 x MS9007 (2 x 1000 ml) Sample Preparation MS9008 Mobile Phase B 1000 ml

MS9100 ClinMass® Add-on Set for Tricyclic Antidepressants in Serum / Plasma 1 pce. One step for 200 assays ➜ Simple and time saving Components (order no. MS9100): sample preparation! MS9112 Internal Standard IS, lyophil. 5 x 5 ml sample preparation MS9113 Serum Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 1 ml Manual 1 pce.

* Reconstitution of IS (order no. MS9112) with 5 ml Precipitant P Start Accessories: (order no. MS9021) MS9114 Optimisation Mix, lyophil. 2 x 2 ml ➜ Flexible and fast LC-MS/MS ClinChek® Controls: Analysis (2.8 min) MS9182 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml

➜ IS contains 12 isotope labeled analytes

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Antiepileptic drugs (AED) are used for the treat- TDM Kit System Chromatogram of the ClinCal® Serum Calibrator, Level 2 (order no. MS9213) ment of epilepsy, a chronic neurological disorder, which is characterised by recurrent epileptic seizures. Antiepileptic Drugs The ClinMass® Add-on Set for Antiepileptic Drugs 8.0 Pregabaline 0.86 Lamotrigine 2.16 (order no. MS9200) contains all analyte specific in Serum / Plasma 7.2 Gabapentin 0.87 10-OH-Carbamazepine 2.29 6.4 Levetiracetam 0.93 Phenobarbital 2.39 components required for the quantification of 26 5.6 Phenylethylmalonamide N-Desmethylmethsuximide 4.8 (PEMA) 1.17 (NDMS) 2.62 different AEDs and metabolites. Ethosuximide 1.29 Carbamazepine-Epoxide 2.70 4.0 Primidone 1.60 Oxcarbazepine 2.98 ® Test Data The ClinMass TDM Platform (order no. MS9000) con - 3.2 Valproic acid 1.68 Topiramate 3.04 2.4 Sultiame 1.70 Carbamazepine 3.36

Test data are available on request. Intensity (cps) tains the components needed for sample preparation 1.6 Lacosamide 1.80 Phenytoin 3.37 and LC-MS/MS analysis. It can be used with all 0.8 Zonisamide 1.83 Tiagabine 3.41 0.0 Felbamate 2.03 Retigabine 3.63 ClinMass® Add-on Sets of the TDM Kit System (BZP, LC-MS/MS Parameters Carbamazepine-Diol 2.08 Perampanel 3.94 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.4 Rufinamide 2.13 Stiripentol 4.07 TCA, …). The analytical column is suitable for the LC-Parameters whole analyte panel (102 compounds). Binary Gradient Pump: Mobile Phases A/B (0.6 ml/min) Retention Time (min) Injection volume: 1 - 10 μl* Injection interval: 4.5 min Ordering Information Column heater: 40 °C Order No. Description Quantity * depending on the sensitivity of the mass spectrometer ® MS-Parameters MS9000 ClinMass TDM Platform 1 pce. for 400 assays Ion source: ESI, positive / negative MS/MS mode: MRM Components (order no. MS9000): MS9005 Autosampler Washing Solution 1000 ml MS9007 Mobile Phase A 2 x MS9007 (2 x 1000 ml) Sample Preparation MS9008 Mobile Phase B 1000 ml

MS9200 ClinMass® Add-on Set for Antiepileptic Drugs in Serum / Plasma 1 pce. One step for 200 assays ➜ Simple and time saving Components (order no. MS9200): sample preparation! MS9212 Internal Standard IS, lyophil. 5 x 5 ml sample preparation MS9213 Serum Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 1 ml Manual 1 pce.

* Reconstitution of IS (order no. MS9212) with 5 ml Precipitant P Start Accessories: (order no. MS9021) MS9214 Optimisation Mix, lyophil. 5 x 2 ml ➜ Flexible and fast LC-MS/MS ClinChek® Controls: Analysis (4.5 min) MS9282 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml

➜ IS contains 17 isotope labeled analytes

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In addition to the classical TCAs (see pages 136 - TDM Kit System Chromatogram of the ClinCal® Serum Calibrator, Level 2 (order no. MS9413) 137) a variety of newer antidepressants (ADP) is available for the treatment of depressions, such as selective serotonin and norepinephrine reuptake Antidepressants inhibitors (SSRIs, SNRIs, NRIs) and TeCAs. 3.8e6 ® 3.4e6 Ritalinic acid 0.76 Opipramol 1.68 The ClinMass Add-on Set for Antidepressants in Serum / Plasma Tranylcypromine 0.89 Paroxetine 1.69 3.0e6 O-Desmethylvenlafaxine 0.92 Mirtazapine 1.70 (order no. MS9400) contains all analyte specific 2.6e6 Moclobemide 1.13 Fluvoxamine 1.78 components required for the quantification of 27 2.2e6 Desmethylmirtazapine 1.15 Trazodone 1.78 Milnacipran 1.15 Duloxetine 1.81 1.8e6 different ADPs and metabolites. Test Data OH-Bupropion 1.21 Desmethylfluoxetine 1.83 1.4e6 Venlafaxine 1.27 Bupropion 1.88 ® The ClinMass TDM Platform (order no. MS9000) con - Test data are available on request. Intensity (cps) 1.0e6 erythro-Dihydro-Bupropion Dosulepin 1.96 threo-Dihydro-Bupropion 1.28* Fluoxetine 1.96 6.0e5 tains the components needed for sample preparation Clomethiazole 1.33 Norsertraline 2.10 2.0e5 Citalopram 1.55 Sertraline 2.30 0.0 and LC-MS/MS analysis. It can be used with all LC-MS/MS Parameters Reboxetine 1.58 Mianserin 2.51 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 2.2 2.4 2.6 Atomoxetine 1.67 ClinMass® Add-on Sets of the TDM Kit System (BZP, LC-Parameters TCA, …). The analytical column is suitable for the Binary Gradient whole analyte panel (102 compounds). Pump: Mobile Phases A/B (0.7 ml/min) Retention Time (min)

Injection volume: 1 - 10 μl* *erythro- and threo-Dihydro-Bupropion can be separated by a modified gradient in an extra run Injection interval: 3.5 min Column heater: 40 °C Ordering Information * depending on the sensitivity of the mass spectrometer Order No. Description Quantity MS-Parameters Ion source: ESI, positive MS9000 ClinMass® TDM Platform 1 pce. for 400 assays MS/MS mode: MRM Components (order no. MS9000): MS9005 Autosampler Washing Solution 1000 ml Sample Preparation MS9007 Mobile Phase A 2 x MS9007 (2 x 1000 ml) 100 μl Precipitant P MS9008 Mobile Phase B 1000 ml TDM (contains IS)* MS9020 Sample Preparation Vials 4 x MS9020 (4 x 100 pcs.) MS9021 Precipitant P 2 x MS9021 (2 x 25 ml)

Start Accessories: MS9030 Analytical Column with test chromatogram 1 pce. Inject 50 μl Sample MS9032 Prefilter 1 pce. supernatant ➜ mix, centrifuge Accessories: MS9022 Diluting Solution D 50 ml

One step MS9400 ClinMass® Add-on Set for Antidepressants in Serum / Plasma 1 pce. ➜ Simple and time saving for 200 assays sample preparation! Components (order no. MS9400): sample preparation MS9412 Internal Standard IS, lyophil. 5 x 5 ml MS9413 Serum Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 1 ml * Reconstitution of IS (order no. MS9412) with 5 ml Precipitant P Manual 1 pce. (order no. MS9021) ➜ Start Accessories: Flexible and fast LC-MS/MS MS9414 Optimisation Mix, lyophil. 2 x 2 ml Analysis (3.5 min) ClinChek® Controls: MS9482 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml

➜ IS contains 20 isotope labeled analytes

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LC-MS/MS Complete Kits

ClinMass® TDM Kit System, on-line Add-on Sets for TDM Platform TDM TDM Kit System, on-line The ClinMass® “TDM Kit System, on-line” is based on a universal TDM Platform (order no. MS9050) that can be used for several different TDM analytes. Select your analyte panel by choosing the suitable ClinMass® Add-on Sets. Currently available are:

Add-on Set for 35 Benzodiazepines BZP (BZP), see pages 144 - 145 Add-on Set for 14 Tricyclic Antidepressants TCA (TCA), see pages 146 - 147 Add-on Set for 27 Antiepileptic Drugs AED (AED), see pages 148 - 149 Add-on Set for 27 Antidepressants ADP (AED), see pages 150 - 151

The benefits: The whole analyte panel is determined on one TDM Platform (i.e. identical mobile phases) and on one analytical column.

No manual sample preparation Additional ClinMass® Add-on Sets in preparation: Neuroleptics (NLP), Antimycotics (AMC), Cytostatics (CYT) (on-line SPE analysis)!

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Benzodiazepines are a group of psychoactive drugs TDM Kit System, on-line Chromatogram of the ClinCal® Serum Calibrator, Level 2 (order no. MS6013) with a broad range of therapeutic effects and be - long to the most frequently prescribed drugs all over the world. Benzodiazepines 7-Aminonitrazepam 2.74 Alprazolam 4.67 The ClinMass® Add-on Set for Benzo dia ze pi nes (order 7-Aminoclonazepam 2.80 Chlordiazepoxide 4.72 3-Hydroxybromazepam 2.96 α-OH-Midazolam 4.78 no. MS9550) contains all analyte specific components in Serum / Plasma 5.6 7-Aminoflunitrazepam 2.96 Triazolam 4.81 4.8 Bromazepam 3.43 Desalkylflurazepam 5.19 required for the quantification of 35 different drugs Zopiclon 3.45 Flunitrazepam 5.19 4.0 Demoxepam 3.57 Temazepam 5.40 and metabolites. Zaleplon 3.71 Nordiazepam 5.54 3.2 α-OH-Triazolam 3.86 Clobazam 5.68 ® Test Data The ClinMass TDM Platform (order no. MS9050) con - 2.4 α-OH-Alprazolam 3.88 Flurazepam 5.73 Desmethylflunitrazepam 4.15 Trazodone 5.74

Test data are available on request. Intensity (cps) tains the components needed for on-line SPE LC- 1.6 Oxazepam 4.26 Lormetazepam 5.77 ® 0.8 Estazolam 4.27 Midazolam 5.92 MS/MS analysis. It can be used with all ClinMass Nitrazepam 4.33 Diazepam 6.23 Add-on Sets of the “TDM Kit System, on-line” (BZP, LC-MS/MS Parameters 0.0 Zolpidem 4.36 Tetrazepam 6.77 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.05.5 6.0 6.5 7.0 Norclobazam 4.53 Prazepam 6.95 TCA, …). The analytical column is suitable for the LC-Parameters Lorazepam 4.53 Medazepam 7.25 Clonazepam 4.60 whole analyte panel (103 compounds). Pump 1 (SPE): gradient program (0.1 - 4 ml/min) Pump 2 (Mobile Phase A, B): Retention Time (min) gradient program (0.6 ml/min) Ordering Information Injection volume: 2 - 20 μl* Order No. Description Quantity Injection interval: 7.5 min ® Column heater: 40 °C MS9050 ClinMass TDM Platform, on-line 1 pce. for 400 assays * depending on the sensitivity of the mass spectrometer MS-Parameters Components (order no. MS9050): MS9005 Autosampler Washing Solution 1000 ml Ion source: ESI, positive MS9007 Mobile Phase A 2 x MS9007 (2 x 1000 ml) MS/MS mode: MRM MS9008 Mobile Phase B 1000 ml

MS9059 SPE-Buffer Load L 2 x MS9059 (2 x 2500 ml) TDM MS9060 SPE-Buffer Wash W 2 x MS9060 (2 x 2500 ml) Sample Preparation MS9071 Reconstitution Solution R 5 ml No manual sample preparation needed! Start Accessories: Direct injection of sample and Internal Standard IS MS9035 Analytical Column with test chromatogram 1 pce. in the ratio 1:1 (autosampler). MS9031 SPE-Column 1 pce. MS9032 Prefilter 1 pce.

Accessories: MS9022 Diluting Solution D 50 ml FK7400 Inline-Filter (stainless steel sieve, free of dead volume) 1 pce. FK7340 Sealings and sieves 4 pcs. each Fully automated on-line method! ➜ No manual sample MS9550 ClinMass® Add-on Set, on-line, for Benzodiazepines in Serum / Plasma 1 pce. preparation needed for 400 assays

Components (order no. MS9550): MS9562 Internal Standard IS, lyophil. 5 ml MS6013 Serum Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 1 ml ➜ Flexible and fast LC-MS/MS Manual 1 pce.

Analysis (7.5 min) Start Accessories: MS6015 - Optimisation Mix 1 - 5, lyophil. 2 ml each MS6019 ClinChek® Controls: ➜ IS contains 20 isotope MS6082 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml labeled analytes

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Tricyclic antidepressants (TCA) are a group of TDM Kit System, on-line Chromatogram of the ClinCal® Serum Calibrator, Level 2 (order no. MS9113) psychoactive drugs which are mainly used for the therapy of endogene depressions, anxiety and pain management. Tricyclic Antidepressants The ClinMass® Add-on Set for TCAs (order no. MS9150) 3.6 Norclozapine 2.49 contains all analyte specific components required for Nordoxepin 2.51 in Serum / Plasma 3.2 Protriptyline 2.81 the quantification of 12 TCAs and two atypical neuro- 2.8 Desipramine 2.83 2.4 Doxepin 2.94 leptics. 2.0 Maprotiline 3.00 Nortriptyline 3.01 ® Test Data 1.6 The ClinMass TDM Platform (order no. MS9050) con - Nortrimipramine 3.14 1.2 Imipramine 3.28

Test data are available on request. Intensity (cps) tains the components needed for on-line SPE LC- 0.8 Norclomipramine 3.35 MS/MS analysis. It can be used with all ClinMass® 0.4 Amitriptyline 3.41 Clozapine 3.45 0.0 Add-on Sets of the “TDM Kit System, on-line” (BZP, LC-MS/MS Parameters Clomipramine 3.51 2.2 2.4 2.6 2.8 3.0 3.2 3.4 3.6 Trimipramine 3.57 TCA, …). The analytical column is suitable for the LC-Parameters whole analyte panel (103 compounds). Pump 1 (SPE): gradient program (0.1 - 5 ml/min) Pump 2 (Mobile Phase A, B): Retention Time (min) gradient program (0.8 ml/min) Ordering Information Injection volume: 3 - 15 μl* Order No. Description Quantity Injection interval: 3.8 min ® Column heater: 40 °C MS9050 ClinMass TDM Platform, on-line 1 pce. for 400 assays * depending on the sensitivity of the mass spectrometer MS-Parameters Components (order no. MS9050): MS9005 Autosampler Washing Solution 1000 ml Ion source: ESI, positive MS9007 Mobile Phase A 2 x MS9007 (2 x 1000 ml) MS/MS mode: MRM MS9008 Mobile Phase B 1000 ml

MS9059 SPE-Buffer Load L 2 x MS9059 (2 x 2500 ml) TDM MS9060 SPE-Buffer Wash W 2 x MS9060 (2 x 2500 ml) Sample Preparation MS9071 Reconstitution Solution R 5 ml No manual sample preparation needed! Start Accessories: Direct injection of sample and Internal Standard IS MS9035 Analytical Column with test chromatogram 1 pce. in the ratio 1:2 (autosampler). MS9031 SPE-Column 1 pce. MS9032 Prefilter 1 pce.

Accessories: MS9022 Diluting Solution D 50 ml FK7400 Inline-Filter (stainless steel sieve, free of dead volume) 1 pce. FK7340 Sealings and sieves 4 pcs. each Fully automated on-line method! ➜ No manual sample MS9150 ClinMass® Add-on Set, on-line, for Tricyclic Antidepressants in Serum / Plasma 1 pce. preparation needed for 400 assays

Components (order no. MS9150): MS9162 Internal Standard IS, lyophil. 5 ml MS9113 Serum Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 1 ml ➜ Flexible and fast LC-MS/MS Manual 1 pce.

Analysis (3.8 min) Start Accessories: MS9114 Optimisation Mix, lyophil. 2 x 2 ml

ClinChek® Controls: ➜ IS contains 12 isotope MS9182 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml labeled analytes

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Antiepileptic drugs (AED) are used for the treat- TDM Kit System, on-line Chromatogram of the ClinCal® Serum Calibrator, Level 2 (order no. MS9213) ment of epilepsy, a chronic neurological disorder, which is characterised by recurrent epileptic seizures. Antiepileptic Drugs The ClinMass® Add-on Set for Antiepileptic Drugs 5.6 Pregabaline 2.01 Lamotrigine 3.60 (order no. MS9250) contains all analyte specific in Serum / Plasma Gabapentin 2.01 10-OH-Carbamazepine 3.76 4.8 Theophylline 2.03 Phenobarbital 4.19 components required for the quantification of 27 Levetiracetam 2.06 Carbamazepine-Epoxide 4.58 4.0 Phenylethylmalonamide N-Desmethylmethsuximide different AEDs and metabolites. 3.2 (PEMA) 2.39 (NDMS) 4.70 Ethosuximide 2.67 Oxcarbazepine 5.12 ® Test Data 2.4 The ClinMass TDM Platform (order no. MS9050) con - Primidone 2.84 Topiramate 5.24 1.6 Sultiame 3.04 Tiagabine 5.34

Test data are available on request. Intensity (cps) tains the components needed for on-line SPE LC- Carbamazepine-Diol 3.09 Phenytoin 5.36 0.8 MS/MS analysis. It can be used with all ClinMass® Lacosamide 3.13 Carbamazepine 5.37 0.0 Felbamate 3.32 Retigabine 5.57 Add-on Sets of the “TDM Kit System, on-line” (BZP, LC-MS/MS Parameters Zonisamide 3.38 Perampanel 5.89 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 Valproic acid 3.40 Stiripentol 6.30 TCA, …). The analytical column is suitable for the LC-Parameters Rufinamide 3.59 whole analyte panel (103 compounds). Pump 1 (SPE): gradient program (0.1 - 4 ml/min) Pump 2 (Mobile Phase A, B): Retention Time (min) gradient program (0.6 ml/min) Ordering Information Injection volume: 3 - 15 μl* Order No. Description Quantity Injection interval: 7.0 min ® Column heater: 40 °C MS9050 ClinMass TDM Platform, on-line 1 pce. for 400 assays * depending on the sensitivity of the mass spectrometer MS-Parameters Components (order no. MS9050): MS9005 Autosampler Washing Solution 1000 ml Ion source: ESI, positive / negative MS9007 Mobile Phase A 2 x MS9007 (2 x 1000 ml) MS/MS mode: MRM MS9008 Mobile Phase B 1000 ml

MS9059 SPE-Buffer Load L 2 x MS9059 (2 x 2500 ml) TDM MS9060 SPE-Buffer Wash W 2 x MS9060 (2 x 2500 ml) Sample Preparation MS9071 Reconstitution Solution R 5 ml No manual sample preparation needed! Start Accessories: Direct injection of sample and Internal Standard IS MS9035 Analytical Column with test chromatogram 1 pce. in the ratio 1:2 (autosampler). MS9031 SPE-Column 1 pce. MS9032 Prefilter 1 pce.

Accessories: MS9022 Diluting Solution D 50 ml FK7400 Inline-Filter (stainless steel sieve, free of dead volume) 1 pce. FK7340 Sealings and sieves 4 pcs. each Fully automated on-line method! ➜ No manual sample MS9250 ClinMass® Add-on Set, on-line, for Antiepileptic Drugs in Serum / Plasma 1 pce. preparation needed for 400 assays

Components (order no. MS9250): MS9262 Internal Standard IS, lyophil. 5 ml MS9213 Serum Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 1 ml ➜ Flexible and fast LC-MS/MS Manual 1 pce.

Analysis (7.0 min) Start Accessories: MS9214 Optimisation Mix, lyophil. 5 x 2 ml

ClinChek® Controls: ➜ IS contains 18 isotope MS9282 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml labeled analytes

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In addition to the classical TCAs (see pages 146 - TDM Kit System, on-line Chromatogram of the ClinCal® Serum Calibrator, Level 2 (order no. MS9413) 147) a variety of newer antidepressants (ADP) is available for the treatment of depressions, such as selective serotonin and norepinephrine reuptake Antidepressants inhibitors (SSRIs, SNRIs, NRIs) and TeCAs. 1.2e6 Ritalinic acid 1.75 Atomoxetine 3.03 1.1e6 ® O-Desmethylvenlafaxine 1.95 Opipramol 3.08 The ClinMass Add-on Set for Antidepressants 1.0e6 in Serum / Plasma Tranylcypromine 1.98 Mirtazapine 3.11 9.0e5 Desmethylmirtazapine 2.27 Duloxetine 3.17 (order no. MS9450) contains all analyte specific 8.0e5 Milnacipran 2.35 Fluvoxamine 3.18 7.0e5 components required for the quantification of 27 Moclobemide 2.40 Desmethylfluoxetine 3.23 6.0e5 OH-Bupropion 2.52 Trazodone 3.29 5.0e5 different ADPs and metabolites. Test Data Venlafaxine 2.52 Fluoxetine 3.31 4.0e5 ® erythro-Dihydro-Bupropion Dosulepin 3.32

Test data are available on request. Intensity (cps) 3.0e5 The ClinMass TDM Platform (order no. MS9050) con - threo-Dihydro-Bupropion 2.56* Bupropion 3.45 2.0e5 Clomethiazole 2.78 Norsertraline 3.51 1.0e5 tains the components needed for on-line SPE LC- Citalopram 2.84 Sertraline 3.63 0.0 MS/MS analysis. It can be used with all ClinMass® LC-MS/MS Parameters Reboxetine 2.98 Mianserin 3.75 1.6 1.8 2.0 2.2 2.4 2.6 2.8 3.0 3.2 3.4 3.6 3.8 4.0 4.2 Paroxetine 3.00 Add-on Sets of the “TDM Kit System, on-line” (BZP, LC-Parameters TCA, …). The analytical column is suitable for the Pump 1 (SPE): gradient program whole analyte panel (103 compounds). (0.1 - 3.5 ml/min) Pump 2 (Mobile Phase A, B): Retention Time (min)

gradient program *erythro- and threo-Dihydro-Bupropion can be separated by a modified gradient in an extra run (0.7 ml/min) Injection volume: 3 - 15 μl* Ordering Information Injection interval: 4.8 min Order No. Description Quantity Column heater: 40 °C ® * depending on the sensitivity of the mass spectrometer MS9050 ClinMass TDM Platform, on-line 1 pce. for 400 assays MS-Parameters Ion source: ESI, positive Components (order no. MS9050): MS9005 Autosampler Washing Solution 1000 ml MS/MS mode: MRM MS9007 Mobile Phase A 2 x MS9007 (2 x 1000 ml) MS9008 Mobile Phase B 1000 ml TDM Sample Preparation MS9059 SPE-Buffer Load L 2 x MS9059 (2 x 2500 ml) MS9060 SPE-Buffer Wash W 2 x MS9060 (2 x 2500 ml) No manual sample preparation needed! MS9071 Reconstitution Solution R 5 ml Direct injection of sample and Internal Standard IS Start Accessories: in the ratio 1:2 (autosampler). MS9035 Analytical Column with test chromatogram 1 pce. MS9031 SPE-Column 1 pce. MS9032 Prefilter 1 pce.

Accessories: MS9022 Diluting Solution D 50 ml FK7400 Inline-Filter (stainless steel sieve, free of dead volume) 1 pce. Fully automated FK7340 Sealings and sieves 4 pcs. each on-line method! ➜ No manual sample

preparation needed MS9450 ClinMass® Add-on Set, on-line, for Antidepressants in Serum / Plasma 1 pce. for 400 assays

Components (order no. MS9450): ➜ MS9462 Internal Standard IS, lyophil. 5 ml Flexible and fast LC-MS/MS MS9413 Serum Calibrator Set, lyophil. (Level 0 - 3) 4 x 1 x 1 ml Analysis (4.8 min) Manual 1 pce. Start Accessories: MS9414 Optimisation Mix, lyophil. 2 x 2 ml ➜ IS contains 20 isotope ClinChek® Controls: MS9482 Serum Control, lyophil., Level I, II 2 x 5 x 1 ml labeled analytes

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LC-MS/MS Complete Kits

ClinSpot® DBS for Dried Blood Spot Analysis

Neonatal Screening Amino Acids and Acylcarnitines . . . 154 - 155 Amino Acids and Acylcarnitines

with Filter-Plates ...... 156 - 157 DBS Homocysteine ...... 158 - 159

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The determination of the amino acids and acylcar- Neonatal Screening nitines profile is an integral part of national neonatal screening programmes. For this purpose RECIPE offers two approved ClinSpot® LC-MS/MS Com - Amino Acids and plete Kits for the use in accredited screening laboratories (order nos. MS10000 and MS10100). The Acylcarnitines in kits contain all reagents needed for the analysis of 26 analytes. The determination of additional acyl- Dried Blood Spots (DBS) carnitines is possible. The entire sample preparation is performed with 96-well-plates, alternatively also Test Data in combination with filter-plates (MS10100, see Test data are available on request. pages 156 - 157), in order to ensure a high sample throughput. LC-MS/MS Parameters LC-Parameters Pump: isocratic (0.1 ml/min) Injection volume: 10 - 20 μl Injection interval: 1.6 min MS-Parameters Ion source: ESI, positive MS/MS mode: MRM

Sample Preparation Extraction: Ordering Information well-plate 1: 3.2 mm disc 100 μl Internal Standard IS Order No. Description Quantity

➜ MS10000 ClinSpot® Complete Kit for Amino Acids and Acylcarnitines in Dried Blood Spots (DBS) 1 pce. extract Transfer: for 960 assays

Transfer supernatant into well-plate 2 Components (order no. MS10000):

MS10005 Autosampler Washing Solution 1000 ml DBS

➜ MS10010 Mobile Phase 1000 ml evaporate Derivatisation: MS10012A Internal Standard IS, lyophil. 100 ml MS10021 Reagent A 100 ml Add 50 μl Reagent B MS10022 Reagent B 50 ml MS10023 Reagent C 100 ml ➜ 1. incubate (60 °C) MS10040 96-Well-Plates (370 μl) 6 x MS10040 (6 x 5 pcs.) Reconstitution: 2. evaporate MS10041 Covers for 96-well-plates 2 x MS10041 (2 x 15 pcs.) Manual 1 pce. Add 100 μl Reagent C Additional Components:

➜ ➜ MS10012 Internal Standard IS, lyophil. 25 ml Method according to reconstitute LC-MS/MS Analysis: CLSI NBS-04A Accessories: Inject 10 - 20 μl MS10042 Protective sheets for 96-well-plate (PE/PP foil, 80 x 140 mm) 50 pcs. MS10045 Backpressure regulator, PEEK version, 34 bar 1 pce. MS10046 Replacement cartridge gold coat, 34 bar 1 pce.

➜ Reliable screening in ClinChek® Controls: only 1.6 min MS10182 Dried Blood Spot Control, Level I, II 2 x 1 x 3 spots

➜ Competent on-site support

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The determination of the amino acids and acylcar- Neonatal Screening nitines profile is an integral part of national neonatal screening programmes. For this purpose RECIPE offers two approved ClinSpot® LC-MS/MS Com plete Amino Acids and Kits for the use in accredited screening laboratories (order nos. MS10100 and MS10000, see pages Acylcarnitines in 154 - 155). The kits contain all reagents needed for the analysis of 26 analytes. The determination of Dried Blood Spots (DBS) additional acylcarnitines is possible. With this kit (MS10100) the sample preparation is performed with Filter-Plates with 96-well-plates combined with filter-plates. Test Data Test data are available on request.

LC-MS/MS Parameters LC-Parameters Pump: isocratic (0.1 ml/min) Injection volume: 10 - 20 μl Injection interval: 1.6 min MS-Parameters Ion source: ESI, positive MS/MS mode: MRM

Sample Preparation Ordering Information Extraction: Order No. Description Quantity

filter-plate + well-plate: MS10100 ClinSpot® Complete Kit for Amino Acids and Acylcarnitines in Dried Blood Spots (DBS) 1 pce. 100 μl Internal Standard IS 3.2 mm disc with Filter-Plates, for 960 assays ➜ 1. extract Components (order no. MS10100): 2. centrifuge MS10005 Autosampler Washing Solution 1000 ml DBS 3. evaporate filtrate MS10010 Mobile Phase 1000 ml Derivatisation: MS10012A Internal Standard IS, lyophil. 100 ml MS10021 Reagent A 100 ml Add 50 μl Reagent B MS10022 Reagent B 50 ml

➜ MS10023 Reagent C 100 ml 1. incubate (60 °C) MS10040 96-Well-Plates (370 μl) 3 x MS10040 (3 x 5 pcs.) Reconstitution: 2. evaporate MS10041 Covers for 96-well-plates 15 pcs. MS10140 96-Well-Filter-Plates (500 μl) with Covers 3 x MS10140 (3 x 5 pcs.) Add 100 μl Reagent C Manual 1 pce. ➜ ➜ reconstitute Additional Components: Method according to LC-MS/MS Analysis: CLSI NBS-04A MS10012 Internal Standard IS, lyophil. 25 ml Inject 10 - 20 μl Accessories: MS10042 Protective sheets for 96-well-plate (PE/PP foil, 80 x 140 mm) 50 pcs. MS10045 Backpressure regulator, PEEK version, 34 bar 1 pce. ➜ Reliable screening in MS10046 Replacement cartridge gold coat, 34 bar 1 pce. ClinChek® Controls: only 1.6 min MS10182 Dried Blood Spot Control, Level I, II 2 x 1 x 3 spots

➜ Competent on-site support

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The determination of homocysteine in dried blood Neonatal Screening Chromatogram (left) and mass traces (right) of the ClinCal® Dried Blood Spot Calibrator, Level 3 (order no. MS2113) spots (DBS) is used for the newborn screening for inherited defects of the methionine metabolism 2.5e4 2.5e4 ® 2.4e4 0.71 0.71 (homocystinuria). The RECIPE ClinMass Com plete 2.3e4 2.1e4 Homocysteine in 2.2e4 1.8e4 Kit allows a reliable determination of total homo - 2.1e4 2.0e4 1.5e4 Homocysteine 1.9e4 1.2e4 m/z: 136.1 ➜ 90.1 cys teine from filter spot specimens. After sample 1.8e4 9000.0 Dried Blood Spots (DBS) 1.7e4 1.6e4 6000.0 preparation (reduction and precipitation step) the 1.5e4 3000.0 1.4e4 0.0 1.3e4 sample analysis is performed with an injection in - 1.2e4 1.1e4 2.3e4 ter val of 1.0 min only. Optionally, the sample pre- Test Data 1.0e4 2.1e4 0.71 9000.0 1.8e4 8000.0 paration can be performed fully automated with Linearity: 0.2 - 104 μmol/l Intensity (cps) 7000.0 Intensity (cps) 1.5e4 6000.0 1.2e4 d4-Homocysteine LOD: 0.07 μmol/l 5000.0 m/z: 140.1 ➜ 94.1 liquid handling systems from several device manu- 4000.0 9000.0 3000.0 6000.0 facturers (96-well-plates). LLOQ: 0.2 μmol/l 2000.0 1000.0 3000.0 Intraassay precision: 2.8 % 0.0 0.0 0.50 0.58 0.66 0.74 0.82 0.90 0.98 0.50 0.60 0.70 0.80 0.90 0.98 Interassay precision: 3.8 %

LC-MS/MS Parameters Retention Time (min) Retention Time (min) LC-Parameters Pump: isocratic (0.7 ml/min) Ordering Information Injection volume: 1 μl Order No. Description Quantity Injection interval: 1.0 min ® Column heater: room temperature MS2100 ClinSpot Complete Kit for Homocysteine in Dried Blood Spots (DBS) 1 pce. for 300 assays

MS-Parameters Kit Components (order no. MS2100): MS2005 Autosampler Washing Solution 1000 ml Ion source: ESI, positive MS2010 Mobile Phase 800 ml MS/MS-Mode: MRM MS2112 Internal Standard IS, lyophil. 5 ml MS2113 Dried Blood Spot Calibrator Set (Level 0 - 3) 4 x 1 x 3 spots MS2020 Sample Preparation Vials 3 x MS2020 (3 x 100 pcs.) Sample Preparation MS2021 Reagent A 5 ml Reduction: MS2022 Reagent B 30 ml Manual 1 pce. Filter Spot Sample 15 μl Reagent A DBS (+ 15 μl Internal Standard) Start Accessories:

➜ MS2030 Analytical Column with test chromatogram 1 pce. mix Precipitation: Accessories: FK6500 Protective sheets for 96-well-plate (aluminium foil, 80 x 140 mm) 100 pcs. 100 μl Reagent B FK6510 96-Well-Plates (370 μl) 5 pcs.

® ➜ ClinChek Controls: 1. mix MS2182 Dried Blood Spot Control, Level I, II 2 x 1 x 3 spots 2. centrifuge LC-MS/MS Analysis: ➜ Simple and quick two-step sample preparation Inject 1 μl of the supernatant

➜ Injection interval: 1.0 min

➜ Optional: method with automated sample preparation (96-well plates)

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LC-MS/MS Opti Mix and IS

ClinMass® Optimisation Mixes and Internal Standards

ClinMass® Optimisation Mixes are intended for the optimisation of the MS/MS parameters and for the subsequent check-up of the analytical system. ClinMass® Internal Standards are used for the internal standardisation of the LC-MS/MS analysis.

ClinMass® Optimisation Mixes and ClinMass® In ter- nal Standards are primarily intended to be used with

LC-MS/MS Complete Kits of RECIPE (CE-IVD). In Opti Mix and IS addition they may be used as kit-independent IVD reagents for the implementation or verification of inhouse methods.

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LC-MS/MS Opti Mix and IS

ClinMass® Optimisation Mixes . . . . 164 - 167

ClinMass® Internal Standards . . . . . 168 - 171 Opti Mix and IS

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Product Survey, Optimisation Mixes

Antidepressants Benzodiazepines ■ Analytes: ■ Analytes: Optimisation Mix 1: 7-Aminoflunitrazepam, 7-aminonitrazepam, demoxepam, flunitrazepam, prazepam, temazepam Atomoxetine, bupropion, citalopram, dosulepin, fluoxetine, mianserin, milnacipran, mirtazapine, Order no. Description Quantity

opipramol, reboxetine, sertraline, trazodone, venlafaxine MS6015 ClinMass® Optimisation Mix 1, lyophil., for Benzodiazepines 2 ml Optimisation Mix 2: Clomethiazole, desmethylfluoxetine, desmethylmirtazapine, O-desmethylvenlafaxine, duloxetine, ■ Analytes: erythro-dihydro-bupropion, fluvoxamine, hydroxybupropion, moclobemide, norsertraline, paroxetine, Bromazepam, clobazam, lormetazepam, nitrazepam, norclobazam, nordiazepam ritalinic acid, tranylcypromine Order no. Description Quantity

Order no. Description Quantity MS6016 ClinMass® Optimisation Mix 2, lyophil., for Benzodiazepines 2 ml

MS9414 ClinMass® Optimisation Mix, lyophil., for Antidepressants (Optimisation Mix 1 and 2) 2 x 2 ml ■ Analytes: Alprazolam, 7-aminoclonazepam, clonazepam, desmethylflunitrazepam, α-hydroxymidazolam, Antiepileptic Drugs medazepam, midazolam, tetrazepam ■ Analytes: Order no. Description Quantity

Optimisation Mix 1: MS6017 ClinMass® Optimisation Mix 3, lyophil., for Benzodiazepines 2 ml Carbamazepine, felbamate, oxcarbazepine, PEMA, rufinamide, vigabatrine Optimisation Mix 2: ■ Analytes: Gabapentine, 10-hydroxy-carbamazepine, perampanel, phenytoin, stiripentol Chlordiazepoxide, desalkylflurazepam, diazepam, flurazepam, α-hydroxyalprazolam, Optimisation Mix 3: trazodone, zolpidem Carbamazepine-diol, lacosamide, levetiracetam, pregabaline, theophylline Order no. Description Quantity

Optimisation Mix 4: MS6018 ClinMass® Optimisation Mix 4, lyophil., for Benzodiazepines 2 ml Carbamazepine-epoxide, lamotrigine, primidone, retigabine, tiagabine Optimisation Mix 5: ■ Analytes: N-desmethylmethsuximide, ethosuximide, phenobarbital, sulthiame, topiramate, valproic acid, zonisamide Estazolam, α-hydroxytriazolam, lorazepam, oxazepam, triazolam, zaleplone Order no. Description Quantity Order no. Description Quantity

MS9214 ClinMass® Optimisation Mix, lyophil., for Antiepileptic Drugs (Optimisation Mix 1 - 5) 5 x 2 ml MS6019 ClinMass® Optimisation Mix 5, lyophil., for Benzodiazepines 2 ml

(Order nos. MS6015 - MS6019: for ClinMass® Complete Kit with order no. MS6000) Antiretrovirals ■ Analytes:

Amprenavir, atazanavir, darunavir, delavirdine, efavirenz, etravirine, indinavir, lopinavir, maraviroc, Ethylglucuronide Opti Mix and IS nelfinavir, nevirapine, raltegravir, ritonavir, saquinavir, tipranavir ■ Analytes:

Order no. Description Quantity Ethylglucuronide, d5-ethylglucuronide, ethylsulfate, d5-ethylsulfate

MS4014 ClinMass® Optimisation Mix, ready for use, for Antiretrovirals 2 ml Order no. Description Quantity

MS8014 ClinMass® Optimisation Mix, ready for use, for Ethylglucuronide and Ethylsulfate 2 ml

(for ClinMass® Complete Kit with order no. MS8000/MS8100)

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Product Survey, Optimisation Mixes

Immunosuppressants Tricyclic Antidepressants ■ Analytes: ■ Analytes: Cyclosporine A, everolimus, sirolimus, tacrolimus Optimisation Mix 1: Order no. Description Quantity Amitriptyline, clomipramine, clozapine, desipramine, doxepin, imipramine, nortriptyline

MS1014 ClinMass® Optimisation Mix 1, lyophil., for Immunosuppressants 2 ml Optimisation Mix 2:

(for ClinMass® Complete Kits with order nos. MS1100 and MS1200) Marproteline, norclozapine, norclomipramine, nordoxepine, nortrimipramine, protriptyline, trimipramine Order no. Description Quantity

■ Analytes: MS9114 ClinMass® Optimisation Mix, lyophil., for Tricyclic Antidepressants 2 x 2 ml

Ascomycin, cyclosporine D, d4-everolimus (Optimisation Mix 1 and 2) Order no. Description Quantity

MS1015 ClinMass® Optimisation Mix 2, lyophil., for Immunosuppressants 3 ml 25-OH Vitamin D2 / D3 ■ Analytes: ■ Analytes:

13 13 13 d12-Cyclosporine A, C2d4-everolimus, Cd3-sirolimus, Cd2-tacrolimus 25-Hydroxy-vitamin D2, 25-hydroxy-vitamin D3, d6-25-hydroxy-vitamin D3 Order no. Description Quantity Order no. Description Quantity

MS1115 ClinMass® Optimisation Mix 2, lyophil., for Immunosuppressants 2 ml MS7014 ClinMass® Optimisation Mix, ready for use, for 25-OH Vitamin D2 / D3 2 ml

(for ClinMass® Complete Kit with order nos. MS1100 and MS1200) ■ Analytes: 25-Hydroxy-vitamin D3, 3-epi-25-hydroxy-vitamin D3 Metanephrines Order no. Description Quantity ■ Analytes: MS7015 ClinMass® Optimisation Mix, ready for use, for 25-OH Vitamin D3 1 ml

Metanephrine, d3-metanephrine, 3-methoxytyramine, d4-3-methoxytyramine, normetanephrine, and C-3 Epimer

d3-normetanephrine

Order no. Description Quantity (Order nos. MS7014 - MS7015: for ClinMass® Complete Kits with order nos. MS7000 and MS7100)

MS11014 ClinMass® Optimisation Mix, ready for use, for Metanephrines 2 ml

Methylmalonic Acid ■ Analytes:

Methylmalonic acid, d3-methylmalonic acid Order no. Description Quantity

MS5114 ClinMass Optimisation Mix, ready for use, for Methylmalonic Acid 2 ml Opti Mix and IS

(for ClinMass® Complete Kit with order no. MS5100)

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Product Survey, Internal Standards

Amino Acids and Acylcarnitines Antiretrovirals ■ Analytes: ■ Analytes:

Amino Acids: d4-Amprenavir, d5-atazanavir, d9-darunavir, d4-efavirenz, d8-etravirine, d6-indinavir,

13 15 13 13 2 13 13 15 C3 N-Alanine, C6-arginine, C4-aspartic acid, H7-citrulline, C5-glutamic acid, 2- C N-glycine, d8-lopinavir, d6-maraviroc, d3-nelfinavir, d5-nevirapine, d3-raltegravir, d6-ritonavir,

2 2 2 13 13 13 2 H3-leucine, H3-methionine, H6-ornithine, C6-phenylalanine, C5-proline, C6-tyrosine, H8-valine d6-saquinavir, d4-tipranavir Acylcarnitines: Order no. Description Quantity

2 2 2 2 2 2 ® H9-C0 ( H9-carnitine), H3-C2 ( H3-acetylcarnitine), H3-C3 ( H3-propionylcarnitine), MS4012 ClinMass Internal Standard, ready for use, for Antiretrovirals 2 ml

2 2 2 2 2 2 H3-C4 ( H3-butyrylcarnitine), H9-C5 ( H9-isovalerylcarnitine), H9-C5DC ( H9-glutarylcarnitine),

2 2 2 2 2 2 H3-C6 ( H3-hexanoylcarnitine), H3-C8 ( H3-octanoylcarnitine), H3-C10 ( H3-decanoylcarnitine),

2 2 2 2 H3-C12 ( H3-dodecanoylcarnitine), H3-C14 ( H3-tetradecanoylcarnitine), Benzodiazepines

2 2 2 2 H3-C16 ( H3-hexadecanoylcarnitine), H3-C18 ( H3-octadecanoylcarnitine) ■ Analytes:

Order no. Description Quantity d5-Alprazolam, d4-7-aminoclonazepam, d7-7-aminoflunitrazepam, d5-α-hydroxyalprazolam,

® MS10012 ClinMass Internal Standard, lyophil., for Amino Acids and Acylcarnitines 25 ml d4-α-hydroxymidazolam, d4-α-hydroxytriazolam, d4-clonazepam, d5-chlordiazepoxide, d5-diazepam,

® (for ClinMass Complete Kits with order nos. MS10000 and MS10100) d5-estazolam, d7-flunitrazepam, d4-lorazepam, d4-midazolam, d5-nitrazepam, d5-nordiazepam,

® MS10012A ClinMass Internal Standard, lyophil., for Amino Acids and Acylcarnitines 100 ml d5-oxazepam, d5-prazepam, d5-temazepam, d4-triazolam, d6-zolpidem

(for ClinMass® Complete Kits with order nos. MS10000 and MS10100) Order no. Description Quantity

MS9512 ClinMass® Internal Standard, lyophil., for Benzodiazepines 5 x 5 ml (for TDM Platform, Add-on Set order no. MS9500) Antidepressants MS9562 ClinMass® Internal Standard, lyophil., for Benzodiazepines 5 ml ■ Analytes: (for TDM Platform, on-line, Add-on Set order no. MS9550)

d3-Atomoxetine, d9-bupropion, d6-citalopram, d5-desmethylfluoxetine, d4-desmethylsertraline,

d3-dosulepin, d7-duloxetine, d5-fluoxetine, d3-fluvoxamine, d3-mianserin, d10-milnacipran,

d3-mirtazapine, d8-moclobemide, d4-opipramol, d4-paroxetine, d5-reboxetine, d3-sertraline, Ethylglucuronide

d5-tranylcypromine, d9-threo-dihydro-bupropion, d6-venlafaxine ■ Analytes:

Order no. Description Quantity d5-Ethylglucuronide, d5-ethylsulfate

MS9412 ClinMass® Internal Standard, lyophil., for Antidepressants 5 x 5 ml Order no. Description Quantity

(for TDM Platform, Add-on Set order no. MS9400) MS8012 ClinMass® Internal Standard, ready for use, for Ethylglucuronide 100 ml

MS9462 ClinMass® Internal Standard, lyophil., for Antidepressants 5 ml (in Diluting Solution D for ClinMass® Complete Kit with order no. MS8000)

(for TDM Platform, on-line, Add-on Set order no. MS9450) MS8112 ClinMass® Internal Standard, ready for use, for Ethylglucuronide 30 ml

(in Precipitant P for ClinMass® Complete Kit with order no. MS8100)

Antiepileptic Drugs Opti Mix and IS ■ Analytes: Homocysteine

13 d10-Carbamazepine, d3-ethosuximide, d4-felbamate, d3-lacosamide, C3-lamotrigine, ■ Analytes:

d6-levetiracetam, d4-oxcarbazepine, d5-PEMA, d5-phenobarbital, d4-pregabaline, d8-Homocystine

d5-primidone, d4-retigabine, d9-stiripentol, d6-theophylline, d6-tiagabine, d12-topiramate, Order no. Description Quantity

15 ® d6-valproic acid, d4 N-zonisamide MS2012 ClinMass Internal Standard, lyophil., for Homocysteine 5 ml

Order no. Description Quantity (for ClinMass® Complete Kit with order no. MS2000)

MS9212 ClinMass® Internal Standard, lyophil., for Antiepileptic Drugs 5 x 5 ml MS2112 ClinMass® Internal Standard, lyophil., for Homocysteine 5 ml

(for TDM Platform, Add-on Set order no. MS9200) (for ClinMass® Complete Kit with order no. MS2100)

MS9262 ClinMass® Internal Standard, lyophil., for Antiepileptic Drugs 5 ml (for TDM Platform, on-line, Add-on Set order no. MS9250)

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Product Survey, Internal Standards

Immunosuppressants Methylmalonic Acid ■ Analytes: ■ Analytes:

Ascomycin d3-Methylmalonic acid Order no. Description Quantity Order no. Description Quantity

MS1012 ClinMass® Internal Standard, lyophil., for Immunosuppressants 2 μg MS5112 ClinMass® Internal Standard for Methylmalonic Acid 40 ml

(in Precipitant P, for ClinMass® Complete Kit with order no. MS5100) ■ Analytes: Cyclosporine D Order no. Description Quantity Nicotine and Metabolites MS1112 ClinMass® Internal Standard, lyophil., for Immunosuppressants 18 μg ■ Analytes:

d3-Cotinine, d3-hydroxycotinine, d3-nicotine ■ Analytes: Order no. Description Quantity

® Ascomycin, cyclosporine D, d4-everolimus MS3012 ClinMass Internal Standard, ready for use, for Nicotine and Metabolites 1.5 ml Order no. Description Quantity

MS1212 ClinMass® Internal Standard, lyophil., for Immunosuppressants 3 ml Tricyclic Antidepressants ■ Analytes: ■ Analytes:

13 13 13 d12-Cyclosporine A, C2d4-everolimus, Cd3-sirolimus, Cd2-tacrolimus d3-Amitriptyline, d3-clomipramine, d4-clozapine, d3-desipramine, d3-doxepin, d3-imipramine,

Order no. Description Quantity d5-maproteline, d3-norclomipramine, d8-norclozapine, d3-nordoxepin, d3-nortriptyline, d3-trimipramine

MS1312 ClinMass® Internal Standard, lyophil., for Immunosuppressants 6.25 / 0.5 / Order no. Description Quantity

0.5 / 0.5 μg MS9112 ClinMass® Internal Standard, lyophil., for Tricyclic Antidepressants 5 x 5 ml ■ Analytes: (for TDM Platform, Add-on Set order no. MS9100)

13 13 13 ® d12-Cyclosporine A, C2d4-everolimus, Cd3-sirolimus, Cd2-tacrolimus MS9162 ClinMass Internal Standard, lyophil., for Tricyclic Antidepressants 5 ml Order no. Description Quantity (for TDM Platform, on-line, Add-on Set order no. MS9150)

MS1412 ClinMass® Internal Standard, lyophil., for Immunosuppressants 3 ml

(for ClinMass® Complete Kits with order nos. MS1100 and MS1200) 25-OH Vitamin D2 / D3 ■ Analytes:

Metanephrines d6-25-Hydroxy-vitamin D3 ■ Analytes: Order no. Description Quantity

® d3-Metanephrine, d4-3-methoxytyramine, d3-normetanephrine MS7012 ClinMass Internal Standard, ready for use, for 25-OH Vitamin D2 / D3 30 ml

Order no. Description Quantity (for ClinMass Complete Kit with order no. MS7000) Opti Mix and IS

MS11012 ClinMass® Internal Standard for Metanephrines 30 ml MS7112 ClinMass® Internal Standard, lyophil., for 25-OH Vitamin D2 / D3 2 μg

(in Precipitant P, for ClinMass® Complete Kit with order no. MS11000)

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www.recipe.de/en/updates.html

Datasheet updates available: free and thus are ready to use. ClinCal (ClinCal are prepared for analysis like the patient samples. matrices (urine, plasma, serum, whole blood) and ClinCal ting of the analytical system (ClinTest ensure a coherent QA process including the tes test and reference materials. Our products help to RECIPE provides a wide range of CE-IVD labelled ClinTest Quality Assurance ClinTest ClinChek and ClinChek ® ® ) and quality control (ClinChek Standard and Test Solutions are matrix- ® ® ® Calibrators ® Controls are available in different Solutions Controls ® ), calibration ® Cali ® ). bra tors - 173

Quality Assurance Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:15 Seite 174

Quality Assurance

ClinTest® Solutions . . . . . 176 - 181 ® ClinTest

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ClinTest® Standard and Test Solutions

Amiodarone Atypical Neuroleptics ■ Analytes: ■ Analytes: Amiodarone, desethylamiodarone, internal standard Clozapine, desmethylclozapine, desmethylolanzapine, internal standard, olanzapine, quetiapine Order no. Description Quantity Order no. Description Quantity

20011 ClinTest® Standard Solution, ready for use, for Amiodarone 1 x 3 ml 40014 ClinTest® Test Solution, lyophil., for Atypical Neuroleptics 5 x 2 ml

■ Analytes: Antiasthmatics Paliperidone (9-OH-risperidone), risperidone ■ Analytes: Order no. Description Quantity

Caffeine, internal standard, theobromine, theophylline 40114 ClinTest® Test Solution, ready for use, for Risperidone, Paliperidone 1 x 15 ml Order no. Description Quantity

12011 ClinTest® Standard Solution, ready for use, for Antiasthmatics 1 x 4 ml β-Carotene ■ Analytes: Antiepileptics See title ■ Analytes: Order no. Description Quantity

Carbamazepine, carbamazepine-epoxide, N-desmethylmethsuximide, ethosuximide, 30014 ClinTest® Test Solution, lyophil., for β-Carotene 1 x 3 ml 10-hydroxy-carbamazepine, internal standard, oxcarbazepine, phenylethylmalonamide, phenobarbital, phenytoin, primidone Order no. Description Quantity Catecholamines 15011 ClinTest® Standard Solution, ready for use, Antiepileptics 1 x 3 ml ■ Analytes: Dopamine, epinephrine, internal standard, norepinephrine ■ Analytes: Order no. Description Quantity

Carbamazepine, carbamazepine-epoxide, ethosuximide, internal standard, 1011 ClinTest® Standard Solution, ready for use, for Catecholamines in Plasma 1 x 10 ml

10-hydroxy-carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin, 2011 ClinTest® Standard Solution, ready for use, for Catecholamines in Urine 1 x 10 ml primidone, sulthiame Order no. Description Quantity 14011 ClinTest® Standard Solution, ready for use, Antiepileptics 3 1 x 3 ml CDT ■ Analytes: ■ Analytes: A-, mono-, di-, tri-, tetra-, penta-, hexasialotransferrin N-Desmethylmethsuximide, felbamate, internal standard, lacosamide, rufinamide, Order no. Description Quantity

zonisamide 21014 ClinTest® Test Solution, ready for use, for CDT 1 x 15 ml Order no. Description Quantity

14111 ClinTest® Standard Solution, ready for use, Antiepileptics 4 1 x 3 ml Coenzyme Q10 ■ Analytes: Aromatic Amino Acids Coenzyme Q10 (ubiquinone), internal standard ■ Analytes: Order no. Description Quantity

Internal standard, phenylalanine, tryptophane, tyrosine 31014 ClinTest® Test Solution, ready for use, for Coenzyme Q10 1 x 3 ml ® Order no. Description Quantity

10011 ClinTest® Standard Solution, ready for use, for Aromatic Amino Acids 1 x 4 ml ClinTest

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ClinTest® Standard and Test Solutions

Hemoglobin A1c Lamotrigine and Sulthiame ■ Analytes: ■ Analytes: See title Internal standard 1, internal standard 2, lamotrigine, sulthiame Order no. Description Quantity Order no. Description Quantity

11011 ClinTest® Reference Standard, ready for use, for HbA1c 10 x 5 ml 15111 ClinTest® Standard Solution, ready for use, for Lamotrigine and Sulthiame 1 x 3 ml

Hemoglobin Variants Levetiracetam (Keppra®) ■ Analytes: ■ Analytes: Hemoglobin A0, A1c, A2, C, D, E, F, S Internal standard, levetiracetam Order no. Description Quantity Order no. Description Quantity

13114 ClinTest® Test Solution, ready for use, for Hemoglobin Variants 5 x 3 ml 15511 ClinTest® Standard Solution, ready for use, for Levetiracetam 1 x 3 ml

Hippuric Acids Metanephrines ■ Analytes: ■ Analytes: Hippuric acid, internal standard, m-methyl-hippuric acid, o-methyl-hippuric acid Internal standard, metanephrine, 3-methoxytyramine, normetanephrine Order no. Description Quantity Order no. Description Quantity

52011 ClinTest® Standard Solution, ready for use, for Hippuric Acids 1 x 3 ml 4011 ClinTest® Standard Solution, ready for use, for Metanephrines 1 x 10 ml

Homocysteine t,t-Muconic Acid ■ Analytes: ■ Analytes: Cysteine, cysteinylglycine, homocysteine, internal standard Internal standard, t,t-muconic acid Order no. Description Quantity Order no. Description Quantity

23011 ClinTest® Standard Solution, ready for use, for Homocysteine 1 x 3 ml 51011 ClinTest® Standard Solution, ready for use, for t,t-Muconic Acid 1 x 3 ml

Hydroxyproline Mycophenolic Acid ■ Analytes: ■ Analytes: Hydroxyproline, internal standard Internal standard, mycophenolic acid Order no. Description Quantity Order no. Description Quantity

16011 ClinTest® Standard Solution, ready for use, for Hydroxyproline 1 x 5 ml 29014 ClinTest® Test Solution, ready for use, for Mycophenolic Acid 1 x 3 ml ® ClinTest

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ClinTest® Standard and Test Solutions

Porphyrins Vitamin B6 ■ Analytes: ■ Analytes: Coproporphyrin I, coproporphyrin III, heptacarboxyporphyrin I, hexacarboxyporphyrin I ab, Pyridoxal, Pyridoxal-5-phosphate hexacarboxyporphyrin I ac, internal standard, pentacarboxyporphyrin I, uroporphyrin I Order no. Description Quantity

Order no. Description Quantity 26011 ClinTest® Standard Solution, ready for use, for Vitamin B6 1 x 3 ml 17011 ClinTest® Standard Solution, ready for use, for Porphyrins 1 x 5 ml

Vitamin C Serotonin ■ Analytes: ■ Analytes: See title Internal standard, serotonin Order no. Description Quantity

Order no. Description Quantity 28014 ClinTest® Test Solution, lyophilised, for Vitamin C 5 x 1 ml 6711 ClinTest® Standard Solution, lyophilised, for Serotonin 5 x 2 ml

25-OH Vitamin D2 / D3 Vitamin A and E ■ Analytes: ■ Analytes: Internal standard, 25-hydroxy vitamin D2, 25-hydroxy vitamin D3 Internal standard, vitamin A, vitamin E Order no. Description Quantity

Order no. Description Quantity 35014 ClinTest® Test Solution, lyophilised, for 25-hydroxy Vitamin D2 / D3 2 x 2 ml 22011 ClinTest® Standard Solution, ready for use, for Vitamin A and E 1 x 3 ml

VMA , HVA, and 5-HIAA Vitamin B1 ■ Analytes: ■ Analytes: Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), internal standard, Thiamine, thiaminemonophosphate (TMP), thiaminepyrophosphate (TPP) vanillylmandelic acid (VMA) Order no. Description Quantity Order no. Description Quantity

24014 ClinTest® Test Solution, ready for use, for Vitamin B1 1 x 3 ml 3011 ClinTest® Standard Solution, lyophilised, for VMA/HVA/5-HIAA 5 x 1 ml

Vitamin B2 ■ Analytes: Flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), riboflavin Order no. Description Quantity

25014 ClinTest® Test Solution, lyophilised, for Vitamin B2 5 x 2 ml ® ClinTest

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Quality Assurance

ClinCal® Calibrators

Analyte Survey ...... 184 - 199

Product Survey Urine Calibrators ...... 200 - 202 Plasma Calibrators ...... 202 - 204 Serum Calibrators ...... 204 - 208 Whole Blood Calibrators ...... 209 ® ClinCal

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With ClinCal® Calibrator Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinCal® Calibrator Order No. Page Analyte Matrix ClinCal® Calibrator Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

5-ALA (5-Aminolevulinic acid) ● ClinCal® 5-ALA, PBG 17213 200 Atomoxetine ● ClinCal® Antidepressants MS9413 204 ● ClinCal® Porphyrins 17013 201 Barium ● ClinCal® Trace Elements 9988 201 Alanine ● ClinCal® Amino Acids 10213 202 ● 9982 208

Alprazolam ● ClinCal® Benzodiazepines MS6013 206 Beryllium ● ClinCal® Trace Elements 9988 201 ● 9985 204 Aluminium ● ClinCal® Trace Elements 9988 201 ● 9982 208 ● 9985 204 ● 9982 208 Bismuth ● ClinCal® Trace Elements 9985 204 ● 9982 208 α-Aminobutyric acid ● ClinCal® Amino Acids 10213 202 Bisphenol A ● ClinCal® Phenolic Compounds 9925 201 7-Aminoclonazepam ● ClinCal® Benzodiazepines MS6013 206 Bromazepam ● ClinCal® Benzodiazepines MS6013 206 7-Aminoflunitrazepam ● ClinCal® Benzodiazepines MS6013 206 Bromide ● ClinCal® Antiepileptics 15013 205 5-Aminolevulinic acid (5-ALA) ● ClinCal® 5-ALA, PBG 17213 200 ● ClinCal® Porphyrins 17013 201 Bupropion ● ClinCal® Antidepressants MS9413 204 ● ClinCal® Psychoactive Drugs TDM6 9717 207 7-Aminonitrazepam ● ClinCal® Benzodiazepines MS6013 206 Butoxy acetic acid ● ClinCal® Occupational Medicine 9922 201 Amiodarone ● ClinCal® Amiodarone 9909 204 ● 20013 204 Cadmium ● ClinCal® Trace Elements 9988 201 ● 9985 204 Amisulpride ● ClinCal® Psychoactive Drugs TDM2 9705 207 ● 9982 208 ● 9943 209 Amitriptyline ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● ClinCal® Tricyclic Antidepressants MS9113 208 Caffeine ● ClinCal® Antiasthmatics 12013 202

Amprenavir ● ClinCal® Antiretrovirals MS4013 205 Carbamazepine ● ClinCal® Antiepileptics 15013 205 ● ClinCal® Antiepileptics 3 14013 205 Androstenedione ● ClinCal® Steroids MS12013 207 ● ClinCal® Antiepileptics 5 MS9213 205

Antimony ● ClinCal® Trace Elements 9988 201 Carbamazepine-diol ● ClinCal® Antiepileptics 5 MS9213 205 ● 9985 204 ● 9982 208 Carbamazepine-epoxide ● ClinCal® Antiepileptics 15013 205 ● ClinCal® Antiepileptics 3 14013 205 Arginine ● ClinCal® Amino Acids 10213 202 ● ClinCal® Antiepileptics 5 MS9213 205

Aripiprazole ● ClinCal® Psychoactive Drugs TDM1 9702 207 β-Carotene, all-trans ● ClinCal® β-Carotene 30013 203 ● ClinCal® Psychoactive Drugs TDM6 9717 207 Chlordiazepoxide ● ClinCal® Benzodiazepines MS6013 206 Arsenic ● ClinCal® Trace Elements 9988 201 ● 9985 204 Chromium ● ClinCal® Trace Elements 9988 201 ● 9982 208 ● 9985 204 ● 9943 209 ● 9982 208 ● 9943 209 Ascorbic acid (Vitamin C) ● ClinCal® Vitamin C 28013 208 Citalopram ● ClinCal® Antidepressants MS9413 204 Asparagine ● ClinCal® Amino Acids 10213 202 ● ClinCal® Psychoactive Drugs TDM1 9702 207 ● ClinCal® Psychoactive Drugs TDM6 9717 207 Aspartic acid ● ClinCal® Amino Acids 10213 202 Citrulline ● ClinCal® Amino Acids 10213 202

Atazanavir ● ClinCal® Antiretrovirals MS4013 205 ® ClinCal

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With ClinCal® Calibrator Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinCal® Calibrator Order No. Page Analyte Matrix ClinCal® Calibrator Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Clobazam ● ClinCal® Benzodiazepines MS6013 206 21-Deoxycortisol ● ClinCal® Steroids MS12013 207

Clomethiazole ● ClinCal® Antidepressants MS9413 204 Desalkylflurazepam ● ClinCal® Benzodiazepines MS6013 206

Clomipramine ● ClinCal® Psychoactive Drugs TDM4 9711 207 Desethylamiodarone ● ClinCal® Amiodarone 9909 204 ● ClinCal® Tricyclic Antidepressants MS9113 208 ● 20013 204

Clonazepam ● ClinCal® Benzodiazepines MS6013 206 Desipramine ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● ClinCal® Tricyclic Antidepressants MS9113 208 Clozapine ● ClinCal® Atypical Neuroleptics 40013 202 ● ClinCal® Psychoactive Drugs TDM3 9708 207 Desmethylcitalopram ● ClinCal® Psychoactive Drugs TDM1 9702 207 ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● ClinCal® Tricyclic Antidepressants MS9113 208 Desmethylclozapine ● ClinCal® Atypical Neuroleptics 40013 202 (Norclozapine) ● ClinCal® Psychoactive Drugs TDM3 9708 207 Cobalt ● ClinCal® Trace Elements 9988 201 ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● 9985 204 ● ClinCal® Tricyclic Antidepressants MS9113 208 ● 9982 208 ● 9943 209 Desmethylflunitrazepam ● ClinCal® Benzodiazepines MS6013 206 (Norflunitrazepam) Coenzyme Q10 (Ubiquinone) ● ClinCal® Coenzyme Q10 31013 203 Desmethylfluoxetine ● ClinCal® Antidepressants MS9413 204 Copper ● ClinCal® Trace Elements 9988 201 ● ClinCal® Psychoactive Drugs TDM6 9717 207 ● 9985 204 ● 9982 208 N-Desmethylmethsuximide ● ClinCal® Antiepileptics 15013 205 ● 9943 209 (NDMS) ● ClinCal® Antiepileptics 4 14113 205 ● ClinCal® Antiepileptics 5 MS9213 205 Coproporphyrin I ● ClinCal® Porphyrins 17013 201 Desmethylmirtazapine ● ClinCal® Antidepressants MS9413 204 Coproporphyrin III ● ClinCal® Porphyrins 17013 201 ● ClinCal® Psychoactive Drugs TDM2 9705 207 ● ClinCal® Psychoactive Drugs TDM6 9717 207 Cortisol ● ClinCal® Steroids MS12013 207 Desmethylolanzapine ● ClinCal® Antidepressants MS9413 204 Cotinine ● ClinCal® Nicotine and Metabolites MS3013 201 ● ClinCal® Atypical Neuroleptics 40013 202 ● ClinCal® Psychoactive Drugs TDM3 9708 207 o-Cresol ● ClinCal® Phenolic Compounds 9925 201 Desmethylsertraline ● ClinCal® Antidepressants MS9413 204 Cyclosporine A ● ClinCal® Immunosuppressants 9028 209 ● ClinCal® Psychoactive Drugs TDM6 9717 207 ● 9033 209 ● 9933 209 O-Desmethylvenlafaxine ● ClinCal® Antidepressants MS9413 204 ● ClinCal® Psychoactive Drugs TDM1 9702 207 Darunavir ● ClinCal® Antiretrovirals MS4013 205 ● ClinCal® Psychoactive Drugs TDM2 9705 207 ● ClinCal® Psychoactive Drugs TDM6 9717 207 Dehydro-Aripiprazole ● ClinCal® Psychoactive Drugs TDM6 9717 207 DHEAS (Dehydroepiandrosterone) ● ClinCal® Steroids MS12013 207 Dehydroepiandrosterone (DHEAS) ● ClinCal® Steroids MS12013 207 Diazepam ● ClinCal® Benzodiazepines MS6013 206 Delavirdine ● ClinCal® Antiretrovirals MS4013 205 Diphenylhydantoin (Phenytoin) ● ClinCal® Antiepileptics 15013 205 Demoxepam ● ClinCal® Benzodiazepines MS6013 206 ● ClinCal® Antiepileptics 3 14013 205 ● ClinCal® Antiepileptics 5 MS9213 205 11-Deoxycorticosterone ● ClinCal® Steroids MS12013 207 (21-Hydroxy-Progesterone) Dopamine ● ClinCal® Catecholamines 2013 200 ● 2113 200 11-Deoxycortisol ● ClinCal® Steroids MS12013 207 ● 1013 203 ® ClinCal

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With ClinCal® Calibrator Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinCal® Calibrator Order No. Page Analyte Matrix ClinCal® Calibrator Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Dosulepin ● ClinCal® Antidepressants MS9413 204 Fluoride ● ClinCal® Trace Elements 9988 201 ● 9985 204 Doxepin ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● 9982 208 ● ClinCal® Tricyclic Antidepressants MS9113 208 Fluoxetine ● ClinCal® Antidepressants MS9413 204 Duloxetine ● ClinCal® Antidepressants MS9413 204 ● ClinCal® Psychoactive Drugs TDM6 9717 207 ● ClinCal® Psychoactive Drugs TDM3 9708 207 ● ClinCal® Psychoactive Drugs TDM6 9717 207 Flurazepam ● ClinCal® Benzodiazepines MS6013 206

Efavirenz ● ClinCal® Antiretrovirals MS4013 205 Fluvoxamine ● ClinCal® Antidepressants MS9413 204 ● ClinCal® Psychoactive Drugs TDM6 9717 207 Epinephrine ● ClinCal® Catecholamines 2013 200 ● 2113 200 Gabapentine ● ClinCal® Antiepileptics 2 15213 205 ● 1013 203 ● ClinCal® Antiepileptics 5 MS9213 205

erythro-Dihydro-Bupropion ● ClinCal® Antidepressants MS9413 204 Glutamic acid ● ClinCal® Amino Acids 10213 202 ● ClinCal® Psychoactive Drugs TDM6 9717 207 Glutamine ● ClinCal® Amino Acids 10213 202 Escitalopram ● ClinCal® Psychoactive Drugs TDM2 9705 207 Glutathione ❍ ClinCal® Glutathione 33013 xxx Estazolam ● ClinCal® Benzodiazepines MS6013 206 Glycine ● ClinCal® Amino Acids 10213 202 Ethosuximide ● ClinCal® Antiepileptics 15013 205 ● ClinCal® Antiepileptics 3 14013 205 Gold ● ClinCal® Trace Elements 9988 201 ● ClinCal® Antiepileptics 5 MS9213 205 ● 9985 204 ● 9982 208 Ethoxy acetic acid ● ClinCal® Occupational Medicine 9922 201 Haloperidol ● ClinCal® Psychoactive Drugs TDM3 9708 207 Ethylglucuronide ● ClinCal® Ethylglucuronide MS8413 200 ● MS8713 200 HbA1c (Hemoglobin A1c) ● ClinCal® Hemoglobin A1c (HbA1c) 11011 209 ● MS8113 206 HbA2 (Hemoglobin A2) ● ClinCal® Hemoglobin F / A2 13113 209 Ethylsulfate ● ClinCal® Ethylglucuronide MS8413 200 ● MS8713 200 HbF (Hemoglobin F) ● ClinCal® Hemoglobin F / A2 13113 209 ● MS8113 206 Hemoglobin A1c (HbA1c) ● ClinCal® Hemoglobin A1c (HbA1c) 11011 209 Etravirine ● ClinCal® Antiretrovirals MS4013 205 Hemoglobin A2 (HbA2) ● ClinCal® Hemoglobin F / A2 13113 209 Everolimus ● ClinCal® Immunosuppressants 9028 209 ● 9033 209 Hemoglobin F (HbF) ● ClinCal® Hemoglobin F / A2 13113 209 ● 9933 209 Heptacarboxyporphyrin I ● ClinCal® Porphyrins 17013 201 FAD (Flavin adenine dinucleotide, ● ClinCal® Vitamin B1, B2 and B6 24513 209 Vitamin B2) Hexacarboxyporphyrin lac, lab ● ClinCal® Porphyrins 17013 201

Felbamate ● ClinCal® Antiepileptics 2 15213 205 5-HIAA ● ClinCal® VMA, HVA, 5-HIAA 3013 202 ● ClinCal® Antiepileptics 4 14113 205 (5-Hydroxyindoleacetic acid) ● ClinCal® Antiepileptics 5 MS9213 205 Hippuric acid ● ClinCal® Occupational Medicine 9922 201 Flavin adenine dinucleotide (FAD, ● ClinCal® Vitamin B1, B2 and B6 24513 209 Vitamin B2) Histidine ● ClinCal® Amino Acids 10213 202

Fluconazole ● ClinCal® Antimycotics 9939 202 Homocysteine ● ClinCal® Homocysteine 23013 203 ● MS2013 206

Flunitrazepam ● ClinCal® Benzodiazepines MS6013 206 DBS MS2113 209 ® ClinCal

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With ClinCal® Calibrator Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinCal® Calibrator Order No. Page Analyte Matrix ClinCal® Calibrator Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Homovanillic acid (HVA) ● ClinCal® VMA, HVA, 5-HIAA 3013 202 Isoleucine ● ClinCal® Amino Acids 10213 202

HVA (Homovanillic acid) ● ClinCal® VMA, HVA, 5-HIAA 3013 202 Itraconazole ● ClinCal® Antimycotics 9939 202

α-Hydroxyalprazolam ● ClinCal® Benzodiazepines MS6013 206 Keppra® (Levetiracetam) ● ClinCal® Antiepileptics 2 15213 205 ● ClinCal® Antiepileptics 5 MS9213 205 3-Hydroxybromazepam ● ClinCal® Benzodiazepines MS6013 206 ● ClinCal® Levetiracetam 15513 205

Hydroxybupropion ● ClinCal® Antidepressants MS9413 204 Lacosamide ● ClinCal® Antiepileptics 2 15213 205 ● ClinCal® Psychoactive Drugs TDM6 9717 207 ● ClinCal® Antiepileptics 4 14113 205 ● ClinCal® Antiepileptics 5 MS9213 205 10-Hydroxy-Carbamazepine ● ClinCal® Antiepileptics 15013 205 ● ClinCal® Antiepileptics 2 15213 205 Lamotrigine ● ClinCal® Antiepileptics 2 15213 205 ● ClinCal® Antiepileptics 3 14013 205 ● ClinCal® Antiepileptics 3 14013 205 ● ClinCal® Antiepileptics 5 MS9213 205 ● ClinCal® Antiepileptics 5 MS9213 205 ● ClinCal® Psychoactive Drugs TDM1 9702 207 ● ClinCal® Lamotrigine and Sulthiame 15113 203 ● ClinCal® Psychoactive Drugs TDM1 9702 207 3ʼ-Hydroxycotinine ● ClinCal® Nicotine and Metabolites MS3013 201 Lead ● ClinCal® Trace Elements 9988 201 5-Hydroxyindoleacetic acid ● ClinCal® VMA, HVA, 5-HIAA 3013 202 ● 9943 209 (5-HIAA) Leucine ● ClinCal® Amino Acids 10213 202 Hydroxy-Itraconazole ● ClinCal® Antimycotics 9939 202 Levetiracetam (Keppra®) ● ClinCal® Antiepileptics 2 15213 205 α-Hydroxymidazolam ● ClinCal® Benzodiazepines MS6013 206 ● ClinCal® Antiepileptics 5 MS9213 205 ● ClinCal® Levetiracetam 15513 205 4-Hydroxyproline ● ClinCal® Amino Acids 10213 202 ● ClinCal® Hydroxyproline 16013 200 Lithium ● ClinCal® Trace Elements 9985 204 ● 9982 208 1-Hydroxypyrene ● ClinCal® Phenolic Compounds 9925 201 Lopinavir ● ClinCal® Antiretrovirals MS4013 205 9-Hydroxy-Risperidone ● ClinCal® Psychoactive Drugs TDM3 9708 207 (Paliperidone) ● ClinCal® Risperidone, Paliperidone 40113 203 Lorazepam ● ClinCal® Benzodiazepines MS6013 206

α-Hydroxytriazolam ● ClinCal® Benzodiazepines MS6013 206 Lormetazepam ● ClinCal® Benzodiazepines MS6013 206

25-Hydroxyvitamin D2 ● ClinCal® 25-OH Vitamins D2 / D3 35013 208 Lysine ● ClinCal® Amino Acids 10213 202 ● MS7013 208 Magnesium ● ClinCal® Trace Elements 9988 201 25-Hydroxyvitamin D3 ● ClinCal® 25-OH Vitamins D2 / D3 35013 208 ● 9985 204 ● MS7013 208 ● 9982 208 ● 9943 209 Imipramine ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● ClinCal® Tricyclic Antidepressants MS9113 208 Malondialdehyde ● ClinCal® Malondialdehyde 32013 203

Indinavir ● ClinCal® Antiretrovirals MS4013 205 Mandelic acid ● ClinCal® Occupational Medicine 9922 201

Iodide ● ClinCal® Trace Elements 9988 201 Manganese ● ClinCal® Trace Elements 9988 201 ● 9985 204 ● 9985 204 ● 9982 208 ● 9982 208 ● 9943 209 Iron ● ClinCal® Trace Elements 9988 201 ● 9982 208 Maprotiline ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● ClinCal® Tricyclic Antidepressants MS9113 208

allo-Isoleucine ● ClinCal® Amino Acids 10213 202 ® ClinCal

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With ClinCal® Calibrator Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinCal® Calibrator Order No. Page Analyte Matrix ClinCal® Calibrator Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Maraviroc ● ClinCal® Antiretrovirals MS4013 205 1-Naphtol ● ClinCal® Phenolic Compounds 9925 201

Medazepam ● ClinCal® Benzodiazepines MS6013 206 2-Naphtol ● ClinCal® Phenolic Compounds 9925 201

Mercury ● ClinCal® Trace Elements 9988 201 NDMS ● ClinCal® Antiepileptics 15013 205 ● 9985 204 (N-Desmethylmethsuximide) ● ClinCal® Antiepileptics 4 14113 205 ● 9982 208 ● ClinCal® Antiepileptics 5 MS9213 205 ● 9943 209 Nelfinavir ● ClinCal® Antiretrovirals MS4013 205 Metanephrine ● ClinCal® Metanephrines 4013 200 ● MS11013 206 Nevirapine ● ClinCal® Antiretrovirals MS4013 205

Methionine ● ClinCal® Amino Acids 10213 202 Nickel ● ClinCal® Trace Elements 9988 201 ● 9985 204 Methoxy acetic acid ● ClinCal® Occupational Medicine 9922 201 ● 9982 208 ● 9943 209 3-Methoxytyramine ● ClinCal® Metanephrines 4013 200 ● MS11013 206 Nicotine ● ClinCal® Nicotine and Metabolites MS3013 201

Methylenedianiline ● ClinCal® Occupational Medicine 9922 201 Nitrazepam ● ClinCal® Benzodiazepines MS6013 206

N-Methylformamide ● ClinCal® Occupational Medicine 9922 201 Norclobazam ● ClinCal® Benzodiazepines MS6013 206

m/p-Methyl-hippuric acid ● ClinCal® Occupational Medicine 9922 201 Norclomipramine ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● ClinCal® Tricyclic Antidepressants MS9113 208 o-Methyl-hippuric acid ● ClinCal® Occupational Medicine 9922 201 Norclozapine ● ClinCal® Atypical Neuroleptics 40013 202 1-Methyl-histidine ● ClinCal® Amino Acids 10213 202 (Desmethylclozapine) ● ClinCal® Psychoactive Drugs TDM3 9708 207 ● ClinCal® Psychoactive Drugs TDM4 9711 207 3-Methyl-histidine ● ClinCal® Amino Acids 10213 202 ● ClinCal® Tricyclic Antidepressants MS9113 208

Methylmalonic acid ● ClinCal® Methylmalonic Acid MS5013 206 Nordiazepam ● ClinCal® Benzodiazepines MS6013 206

Mianserin ● ClinCal® Antidepressants MS9413 204 Nordoxepin ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● ClinCal® Psychoactive Drugs TDM6 9717 207 ● ClinCal® Tricyclic Antidepressants MS9113 208

Midazolam ● ClinCal® Benzodiazepines MS6013 206 Norepinephrine ● ClinCal® Catecholamines 2013 200 ● 2113 200 Milnacipran ● ClinCal® Antidepressants MS9413 204 ● 1013 203

Mirtazapine ● ClinCal® Antidepressants MS9413 204 Norflunitrazepam ● ClinCal® Benzodiazepines MS6013 206 ● ClinCal® Psychoactive Drugs TDM2 9705 207 (Desmethylflunitrazepam) ● ClinCal® Psychoactive Drugs TDM6 9717 207 Normetanephrine ● ClinCal® Metanephrines 4013 200 Moclobemide ● ClinCal® Antidepressants MS9413 204 ● MS11013 206

Molybdenum ● ClinCal® Trace Elements 9988 201 Norquetiapin ● ClinCal® Psychoactive Drugs TDM1 9702 207 ● 9985 204 ● 9982 208 Nortrimipramine ● ClinCal® Tricyclic Antidepressants MS9113 208

t,t-Muconic acid ● ClinCal® Occupational Medicine 9922 201 Nortriptyline ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● ClinCal® Tricyclic Antidepressants MS9113 208 Mycophenolic acid ● ClinCal® Mycophenolic Acid 9904 204 ● 29013 204 Olanzapine ● ClinCal® Atypical Neuroleptics 40013 202

● ClinCal® Psychoactive Drugs TDM3 9708 207 ® ClinCal

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With ClinCal® Calibrator Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinCal® Calibrator Order No. Page Analyte Matrix ClinCal® Calibrator Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Opipramol ● ClinCal® Antidepressants MS9413 204 Phenytoin (Diphenylhydantoin) ● ClinCal® Antiepileptics 15013 205 ● ClinCal® Antiepileptics 3 14013 205 Ornithine ● ClinCal® Amino Acids 10213 202 ● ClinCal® Antiepileptics 5 MS9213 205

Oxazepam ● ClinCal® Benzodiazepines MS6013 206 Phosphoserine ● ClinCal® Amino Acids 10213 202

Oxcarbazepine ● ClinCal® Antiepileptics 15013 205 Platinum ● ClinCal® Trace Elements 9988 201 ● ClinCal® Antiepileptics 2 15213 205 ● 9985 204 ● ClinCal® Antiepileptics 3 14013 205 ● 9982 208 ● ClinCal® Antiepileptics 5 MS9213 205 ● 9943 209

Paliperidone ● ClinCal® Psychoactive Drugs TDM3 9708 207 Porphobilinogen (PBG) ● ClinCal® 5-ALA, PBG 17213 200 (9-Hydroxy-Risperidone) ● ClinCal® Risperidone, Paliperidone 40113 203 ● ClinCal® Porphyrins 17013 201

Palladium ● ClinCal® Trace Elements 9988 201 Posaconazole ● ClinCal® Antimycotics 9939 202 ● 9985 204 ● 9982 208 Potassium ● ClinCal® Trace Elements 9943 209 ● 9943 209 Prazepam ● ClinCal® Benzodiazepines MS6013 206 Paroxetine ● ClinCal® Antidepressants MS9413 204 ● ClinCal® Psychoactive Drugs TDM6 9717 207 Pregabaline ● ClinCal® Antiepileptics 2 15213 205 ● ClinCal® Antiepileptics 5 MS9213 205 PBG (Porphobilinogen) ● ClinCal® 5-ALA, PBG 17213 200 ● ClinCal® Porphyrins 17013 201 Primidone ● ClinCal® Antiepileptics 15013 205 ● ClinCal® Antiepileptics 3 14013 205 PCP (Pentachlorophenol) ● ClinCal® Phenolic Compounds 9925 201 ● ClinCal® Antiepileptics 5 MS9213 205

PEMA (Phenylethylmalonamide) ● ClinCal® Antiepileptics 15013 205 17-Hydroxy-Progesterone ● ClinCal® Steroids MS12013 207 ● ClinCal® Antiepileptics 5 MS9213 205 21-Hydroxy-Progesterone ● ClinCal® Steroids MS12013 207 Pentacarboxyporphyrin I ● ClinCal® Porphyrins 17013 201 (11-Deoxycorticosterone)

Pentachlorophenol (PCP) ● ClinCal® Phenolic Compounds 9925 201 Proline ● ClinCal® Amino Acids 10213 202

Perampanel ● ClinCal® Antiepileptics 2 15213 205 Protriptyline ● ClinCal® Tricyclic Antidepressants MS9113 208 ● ClinCal® Antiepileptics 5 MS9213 205 Pyridoxal (Vitamin B6) ● ClinCal® Vitamin B1, B2 and B6 24513 209 Perazine ● ClinCal® Psychoactive Drugs TDM1 9702 207 ● ClinCal® Vitamin B6 26013 208

Phenobarbital ● ClinCal® Antiepileptics 15013 205 Pyridoxal-5-phosphate ● ClinCal® Vitamin B1, B2 and B6 24513 209 ● ClinCal® Antiepileptics 3 14013 205 (Vitamin B6) ● ClinCal® Vitamin B6 26013 208 ● ClinCal® Antiepileptics 5 MS9213 205 Quetiapine ● ClinCal® Atypical Neuroleptics 40013 202 Phenol ● ClinCal® Phenolic Compounds 9925 201 ● ClinCal® Psychoactive Drugs TDM1 9702 207 ● ClinCal® Psychoactive Drugs TDM2 9705 207 Phenylalanine ● ClinCal® Amino Acids 10213 202 ● ClinCal® Psychoactive Drugs TDM3 9708 207 ● ClinCal® Aromatic Amino Acids 10013 202 Raltegravir ● ClinCal® Antiretrovirals MS4013 205 Phenylethylmalonamide (PEMA) ● ClinCal® Antiepileptics 15013 205 ● ClinCal® Antiepileptics 5 MS9213 205 Reboxetine ● ClinCal® Antidepressants MS9413 204

Phenylglyoxylic acid ● ClinCal® Occupational Medicine 9922 201 Retigabine ● ClinCal® Antiepileptics 2 15213 205 ● ClinCal® Antiepileptics 5 MS9213 205 S-Phenylmercapturic acid ● ClinCal® Occupational Medicine 9922 201

Retinol, all-trans (Vitamin A) ● ClinCal® Vitamin A and E 22013 208 ® ClinCal

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With ClinCal® Calibrator Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinCal® Calibrator Order No. Page Analyte Matrix ClinCal® Calibrator Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Risperidone ● ClinCal® Psychoactive Drugs TDM3 9708 207 Thallium ● ClinCal® Trace Elements 9988 201 ● ClinCal® Risperidone, Paliperidone 40113 203 ● 9985 204 ● 9982 208 Ritalinic acid ● ClinCal® Antidepressants MS9413 204 ● 9943 209

Ritonavir ● ClinCal® Antiretrovirals MS4013 205 Theobromine ● ClinCal® Antiasthmatics 12013 202

Rufinamide ● ClinCal® Antiepileptics 2 15213 205 Theophylline ● ClinCal® Antiasthmatics 12013 202 ● ClinCal® Antiepileptics 4 14113 205 ● ClinCal® Antiepileptics 5 MS9213 205 ● ClinCal® Antiepileptics 5 MS9213 205 Thiaminepyrophosphate (TPP, ● ClinCal® Vitamin B1, B2 and B6 24513 209 Saquinavir ● ClinCal® Antiretrovirals MS4013 205 Vitamin B1)

Selenium ● ClinCal® Trace Elements 9988 201 threo-Dihydro-Bupropion ● ClinCal® Antidepressants MS9413 204 ● 9985 204 ● ClinCal® Psychoactive Drugs TDM6 9717 207 ● 9982 208 ● 9943 209 Threonine ● ClinCal® Amino Acids 10213 202

Serine ● ClinCal® Amino Acids 10213 202 Tiagabine ● ClinCal® Antiepileptics 2 15213 205 ● ClinCal® Antiepileptics 5 MS9213 205 Serotonin ● ClinCal® Serotonin 7013 201 ● 6013 204 Tin ● ClinCal® Trace Elements 9988 201 ● 9985 204 Sertindole ● ClinCal® Psychoactive Drugs TDM6 9717 207 ● 9982 208

Sertraline ● ClinCal® Antidepressants MS9413 204 Tipranavir ● ClinCal® Antiretrovirals MS4013 205 ● ClinCal® Psychoactive Drugs TDM6 9717 207 Titanium ● ClinCal® Trace Elements 9982 208 Silver ● ClinCal® Trace Elements 9985 204 ● 9982 208 α-Tocopherol (Vitamin E) ● ClinCal® Vitamin A and E 22013 208 ● 9943 209 Topiramate ● ClinCal® Antiepileptics 2 15213 205 Sirolimus ● ClinCal® Immunosuppressants 9028 209 ● ClinCal® Antiepileptics 5 MS9213 205 ● 9033 209 ● 9933 209 TPP (Thiaminepyrophosphate, ● ClinCal® Vitamin B1, B2 and B6 24513 209 Vitamin B1) Stiripentol ● ClinCal® Antiepileptics 2 15213 205 ● ClinCal® Antiepileptics 5 MS9213 205 Tranylcypromine ● ClinCal® Antidepressants MS9413 204

Sulthiame ● ClinCal® Antiepileptics 2 15213 205 Trazodone ● ClinCal® Antidepressants MS9413 204 ● ClinCal® Antiepileptics 3 14013 205 ● ClinCal® Benzodiazepines MS6013 206 ● ClinCal® Antiepileptics 5 MS9213 205 ● ClinCal® Lamotrigine and Sulthiame 15113 203 Triazolam ● ClinCal® Benzodiazepines MS6013 206

Tacrolimus ● ClinCal® Immunosuppressants 9028 209 Trichloroacetic acid ● ClinCal® Occupational Medicine 9922 201 ● 9033 209 ● 9933 209 Trimipramine ● ClinCal® Psychoactive Drugs TDM4 9711 207 ● ClinCal® Tricyclic Antidepressants MS9113 208 Taurine ● ClinCal® Amino Acids 10213 202 Tryptophane ● ClinCal® Amino Acids 10213 202 Temazepam ● ClinCal® Benzodiazepines MS6013 206 ● ClinCal® Aromatic Amino Acids 10013 202

Testosterone ● ClinCal® Steroids MS12013 207 Tyrosine ● ClinCal® Amino Acids 10213 202 ● ClinCal® Aromatic Amino Acids 10013 202

Tetrazepam ● ClinCal® Benzodiazepines MS6013 206 ® ClinCal

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With ClinCal® Calibrator Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinCal® Calibrator Order No. Page Analyte Matrix ClinCal® Calibrator Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Ubiquinone (Coenzyme Q10) ● ClinCal® Coenzyme Q10 31013 203 Ziprasidone ● ClinCal® Psychoactive Drugs TDM3 9708 207

Urea ● ClinCal® Amino Acids 10213 202 Zolpidem ● ClinCal® Benzodiazepines MS6013 206

Uroporphyrin I ● ClinCal® Porphyrins 17013 201 Zonisamide ● ClinCal® Antiepileptics 2 15213 205 ● ClinCal® Antiepileptics 4 14113 205 Valine ● ClinCal® Amino Acids 10213 202 ● ClinCal® Antiepileptics 5 MS9213 205

Valproic acid ● ClinCal® Antiepileptics 15013 205 Zopiclone ● ClinCal® Benzodiazepines MS6013 206 ● ClinCal® Antiepileptics 5 MS9213 205

Vanadium ● ClinCal® Trace Elements 9988 201 ● 9985 204 ● 9982 208

Vanillylmandelic acid (VMA) ● ClinCal® VMA, HVA, 5-HIAA 3013 202

Venlafaxine ● ClinCal® Antidepressants MS9413 204 ● ClinCal® Psychoactive Drugs TDM1 9702 207 ● ClinCal® Psychoactive Drugs TDM2 9705 207 ● ClinCal® Psychoactive Drugs TDM6 9717 207

Vigabatrine ● ClinCal® Antiepileptics 2 15213 205 ● ClinCal® Antiepileptics 5 MS9213 205

Vitamin A ● ClinCal® Vitamin A and E 22013 208

Vitamin B1 ● ClinCal® Vitamin B1, B2 and B6 24513 209

Vitamin B2 ● ClinCal® Vitamin B1, B2 and B6 24513 209

Vitamin B6 ● ClinCal® Vitamin B1, B2 and B6 24513 209 ● ClinCal® Vitamin B6 26013 208

Vitamin C ● ClinCal® Vitamin C 28013 208

Vitamin D2 ● ClinCal® 25-OH Vitamins D2 / D3 35013 208 ● MS7013 208

Vitamin D3 ● ClinCal® 25-OH Vitamins D2 / D3 35013 208 ● MS7013 208

Vitamin E ● ClinCal® Vitamin A and E 22013 208

VMA (Vanillylmandelic acid) ● ClinCal® VMA, HVA, 5-HIAA 3013 202

Voriconazole ● ClinCal® Antimycotics 9939 202

Zaleplon ● ClinCal® Benzodiazepines MS6013 206

Zinc ● ClinCal® Trace Elements 9988 201 ● 9985 204 ● 9982 208 ● 9943 209 ® ClinCal

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Product Survey Nicotine and Metabolites (Calibrator Set) ■ Analytes: Cotinine, 3ʼ-hydroxycotinine, nicotine The analytes listed in the Analyte Survey (see pages 184 - 199) are included in the following Order no. Description Quantity ClinCal® Urine, Plasma, Serum, and Whole Blood Calibrators: MS3013 ClinCal® Urine Calibrator Set, lyophil., for Nicotine and Metabolites (Level 0 - 6) 7 x 1 x 3 ml

Occupational Medicine ClinCal® Urine Calibrators, Lyophilised: ■ Analytes: Butoxy acetic acid, ethoxy acetic acid, hippuric acid, mandelic acid, methoxy acetic acid, 5-ALA, PBG methylenedianiline, N-methyl-formamide, m/p-methyl-hippuric acid, o-methyl-hippuric acid, ■ Analytes: t,t-muconic acid, phenylglyoxylic acid, S-phenylmercapturic acid, trichloroacetic acid 5-Aminolevulinic acid (5-ALA), porphobilinogen (PBG) Order no. Description Quantity Order no. Description Quantity 9922 ClinCal® Urine Calibrator, lyophil., for Occupational Medicine 5 x 5 ml

17213 ClinCal® Urine Calibrator, lyophil., for 5-ALA, PBG 5 x 5 ml

Phenolic Compounds Catecholamines ■ Analytes: ■ Analytes: Bisphenol A, o-cresol, 1-hydroxypyrene, 1-naphtol, 2-naphtol, pentachlorophenol, phenol Dopamine, epinephrine, norepinephrine Order no. Description Quantity Order no. Description Quantity 9925 ClinCal® Urine Calibrator, lyophil., for Phenolic Compounds 5 x 5 ml

2013 ClinCal® Urine Calibrator, lyophil., for Catecholamines 5 x 8 ml

2113 ClinCal® Urine Calibrator, lyophil., for Catecholamines (FD) 5 x 8 ml Porphyrins ■ Analytes: Ethylglucuronide (Calibrator Sets) 5-Aminolevulinic acid (5-ALA), coproporphyrin I, coproporphyrin III, heptacarboxyporphyrin I, ■ Analytes: hexacarboxyporphyrin Iac + Iab, pentacarboxyporphyrin I, porphobilinogen (PBG), uroporphyrin I Ethylglucuronide, ethylsulfate Order no. Description Quantity Order no. Description Quantity 17013 ClinCal® Urine Calibrator, lyophil., for Porphyrins 5 x 5 ml

MS8413 ClinCal® Urine Calibrator Set, lyophil., for Ethylglucuronide (Level 0 - 3) 4 x 1 x 1 ml

MS8713 ClinCal® Urine Calibrator Set, lyophil., for Ethylglucuronide (Level 0 - 6) 7 x 1 x 1 ml Serotonin ■ Analytes: Hydroxyproline See title ■ Analytes: Order no. Description Quantity See title 7013 ClinCal® Urine Calibrator, lyophil., for Serotonin 5 x 8 ml Order no. Description Quantity

16013 ClinCal® Urine Calibrator, lyophil., for Hydroxyproline 5 x 8 ml Trace Elements ■ Analytes: Metanephrines Al, As, Au, Ba, Be, Cd, Co, Cr, Cu, Fe, Fluoride, Hg, Iodide, Mg, Mn, Mo, Ni, Pb, Pd, Pt, Sb, ■ Analytes: Se, Sn, Tl, V, Zn Metanephrine, 3-methoxytyramine, normetanephrine Order no. Description Quantity Order no. Description Quantity 9988 ClinCal® Urine Calibrator, lyophil., for Trace Elements 5 x 10 ml

4013 ClinCal® Urine Calibrator, lyophil., for Metanephrines 5 x 8 ml ® ClinCal

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Product Survey Atypical Neuroleptics ■ Analytes: Paliperidone (9-hydroxy-risperidone), risperidone VMA, HVA, 5-HIAA Order no. Description Quantity ■ Analytes: 40113 ClinCal® Plasma Calibrator, lyophil., for Risperidone, Paliperidone 5 x 5 ml Vanillylmandelic acid (VMA), homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) Order no. Description Quantity 3013 ClinCal® Urine Calibrator, lyophil., for VMA, HVA, 5-HIAA 5 x 5 ml β-Carotene ■ Analytes: all-trans-β-carotene ClinCal® Plasma Calibrators, Lyophilised: Order no. Description Quantity 30013 ClinCal® Plasma Calibrator, lyophil., for β-Carotene 5 x 0.5 ml Amino Acids (by Amino Acid Analyser) ■ Analytes: Alanine, α-aminobutyric acid, arginine, asparagine, aspartic acid, citrulline, glutamic acid, Catecholamines glutamine, glycine, histidine, 4-hydroxyproline, allo-isoleucine, isoleucine, leucine, lysine, ■ Analytes: methionine, 1-methyl-histidine, 3-methyl-histidine, ornithine, phenylalanine, phosphoserine, Dopamine, epinephrine, norepinephrine proline, serine, taurine, threonine, tryptophane, tyrosine, urea, valine Order no. Description Quantity

Order no. Description Quantity 1013 ClinCal® Plasma Calibrator, lyophil., for Catecholamines 5 x 5 ml

10213 ClinCal® Plasma Calibrator, lyophil., for Amino Acids (by Amino Acid Analyser) 5 x 3 ml

Coenzyme Q10 Antiasthmatics ■ Analytes: ■ Analytes: Coenzyme Q10 (ubichinone) Caffeine, theobromine, theophylline Order no. Description Quantity

Order no. Description Quantity 31013 ClinCal® Plasma Calibrator, lyophil., for Coenzyme Q10 5 x 2 ml

12013 ClinCal® Plasma Calibrator, lyophil., for Antiasthmatics 1 x 3 ml

Homocysteine Antimycotics (Calibrator Set) ■ Analytes: ■ Analytes: See title Fluconazole, hydroxy-itraconazole, itraconazole, posaconazole, voriconazole Order no. Description Quantity

Order no. Description Quantity 23013 ClinCal® Plasma Calibrator, lyophil., for Homocysteine 1 x 3 ml

9939 ClinCal® Plasma Calibrator Set, lyophil., for Antimycotics (Level 0 - 3) 4 x 1 x 1 ml

Lamotrigine and Sulthiame Aromatic Amino Acids ■ Analytes: ■ Analytes: Lamotrigine, sulthiame Phenylalanine, tryptophane, tyrosine Order no. Description Quantity

Order no. Description Quantity 15113 ClinCal® Plasma Calibrator, lyophil., for Lamotrigine and Sulthiame 1 x 3 ml

10013 ClinCal® Plasma Calibrator, lyophil., for Aromatic Amino Acids 1 x 3 ml

Malondialdehyde Atypical Neuroleptics ■ Analytes: ■ Analytes: See title ® Clozapine, desmethylclozapine, desmethylolanzapine, olanzapine, quetiapine Order no. Description Quantity

Order no. Description Quantity 32013 ClinCal® Plasma Calibrator, lyophil., for Malondialdehyde 5 x 0.5 ml ClinCal 40013 ClinCal® Plasma Calibrator, lyophil., for Atypical Neuroleptics 5 x 3 ml

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Product Survey Antiepileptics (Single Point / Calibrator Set) ■ Analytes: Bromide, carbamazepine, carbamazepine-epoxide, N-desmethylmethsuximide, ethosuximide, Mycophenolic Acid (Single Point / Calibrator Set) 10-hydroxy-carbamazepine, oxcarbazepine, phenobarbital, phenylethylmalonamide, phenytoin, ■ Analytes: primidone, valproic acid See title Order no. Description Quantity

Order no. Description Quantity 15013 ClinCal® Serum Calibrator, lyophil., Antiepileptics 1 x 3 ml

29013 ClinCal® Plasma Calibrator, lyophil., for Mycophenolic Acid (single point) 1 x 3 ml

9904 ClinCal® Plasma Calibrator Set, lyophil., for Mycophenolic Acid (Level 0 - 3) 4 x 1 x 1 ml ■ Analytes: Felbamate, gabapentine, 10-hydroxy-carbamazepine, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, perampanel, pregabaline, retigabine, rufinamide, stiripentol, sulthiame, tiagabine, Serotonin topiramate, vigabatrine, zonisamide ■ Analytes: Order no. Description Quantity

See title 15213 ClinCal® Serum Calibrator, lyophil., Antiepileptics 2 1 x 2 ml Order no. Description Quantity

6013 ClinCal® Plasma Calibrator, lyophil., for Serotonin 1 x 5 ml ■ Analytes: Carbamazepine, carbamazepine-epoxide, ethosuximide, 10-hydroxy-carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin, primidone, sulthiame Trace Elements Order no. Description Quantity ■ Analytes: 14013 ClinCal® Serum Calibrator, lyophil., Antiepileptics 3 1 x 3 ml Ag, Al, As, Au, Be, Bi, Cd, Co, Cr, Cu, Fluoride, Hg, Iodide, Li, Mg, Mn, Mo, Ni, Pd, Pt, Sb, Se, Sn, Tl, V, Zn ■ Analytes: Order no. Description Quantity N-Desmethylmethsuximide, felbamate, lacosamide, rufinamide, zonisamide 9985 ClinCal® Plasma Calibrator, lyophil., for Trace Elements 5 x 3 ml Order no. Description Quantity

14113 ClinCal® Serum Calibrator, lyophil., Antiepileptics 4 1 x 3 ml

ClinCal® Serum Calibrators, Lyophilised: ■ Analytes: Carbamazepine, carbamazepine-diol, carbamazepine-epoxide, N-desmethylmethsuximide, Amiodarone (Single Point / Calibrator Set) ethosuximide, felbamate, gabapentine, 10-hydroxy-carbamazepine, lacosamide, lamotrigine, ■ Analytes: levetiracetam, oxcarbazepine, perampanel, phenobarbital, phenylethylmalonamide, Amiodarone, desethylamiodarone phenytoin, pregabalin, primidone, retigabine, rufinamide, stiripentol, sulthiame, theophylline, Order no. Description Quantity tiagabine, topiramate, valproic acid, vigabatrine, zonisamide 20013 ClinCal® Serum Calibrator, lyophil., for Amiodarone 1 x 3 ml Order no. Description Quantity

9909 ClinCal® Serum Calibrator Set, lyophil., for Amiodarone (Level 0 - 3) 4 x 1 x 2 ml MS9213 ClinCal® Serum Calibrator Set, lyophil., Antiepileptics 5 (Level 0 - 3) 4 x 1 x 1 ml

■ Analytes: Antidepressants (Calibrator Set) Levetiracetam (Keppra®) ■ Analytes: Order no. Description Quantity

Atomoxetine, bupropion, citalopram, clomethiazole, desmethylfluoxetine, desmethylmirtazapine, 15513 ClinCal® Serum Calibrator, lyophil., for Levetiracetam (Keppra®) 1 x 3 ml N-desmethylsertraline, O-desmethylvenlafaxine, dosulepin, duloxetine, erythro-dihydro-bupropion, fluoxetine, fluvoxamine, hydroxybupropion, mianserin, milnacipran, mirtazapine, moclobemide, opipramol, paroxetine, reboxetine, ritalinic acid, sertraline, threo-dihydro-bupropion, tranylcypromine, Antiretrovirals (Calibrator Set) trazodone, venlafaxine ■ Analytes: Order no. Description Quantity Amprenavir, atazanavir, darunavir, delavirdine, efavirenz, etravirine, indinavir, lopinavir, MS9413 ClinCal® Serum Calibrator Set, lyophil., for Antidepressants (Level 0 - 3) 4 x 1 x 1 ml maraviroc, nelfinavir, nevirapine, raltegravir, ritonavir, saquinavir, tipranavir ® Order no. Description Quantity

MS4013 ClinCal® Serum Calibrator Set, lyophil., for Antiretrovirals (Level 0 - 6) 7 x 1 x 0.5 ml ClinCal

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Product Survey Psychoactive Drugs TDM 1 - TDM 4, TDM 6 ■ Analytes: Aripiprazole, citalopram, desmethylcitalopram, O-desmethylvenlafaxine, 10-hydroxy-carbamazepine, Benzodiazepines (Calibrator Set) lamotrigine, norquetiapine, perazine, quetiapine, venlafaxine ■ Analytes: Order no. Description Quantity Alprazolam, 7-aminoclonazepam, 7-aminoflunitrazepam, 7-aminonitrazepam, bromazepam, 9702 ClinCal® Serum Calibrator, lyophil., for Psychoactive Drugs TDM1 5 x 5 ml chlordiazepoxide, clobazam, clonazepam, demoxepam, desalkylflurazepam, desmethylflunitrazepam, diazepam, estazolam, flunitrazepam, flurazepam, 3-hydroxy-bromazepam, α-hydroxyalprazolam, ■ Analytes: α-hydroxymidazolam, α-hydroxytriazolam, lorazepam, lormetazepam, medazepam, midazolam, Amisulpride, desmethylmirtazapine, O-desmethylvenlafaxine, escitalopram, mirtazapine, quetiapine, nitrazepam, norclobazam, nordiazepam, oxazepam, prazepam, temazepam, tetrazepam, trazodone, venlafaxine triazolam, zaleplon, zolpidem, zopiclone Order no. Description Quantity Order no. Description Quantity 9705 ClinCal® Serum Calibrator, lyophil., for Psychoactive Drugs TDM2 5 x 5 ml

MS6013 ClinCal® Serum Calibrator Set, lyophil., for Benzodiazepines (Level 0 - 3) 4 x 1 x 1 ml ■ Analytes: Clozapine, desmethylclozapine, desmethylolanzapine, duloxetine, haloperidol, olanzapine, Ethylglucuronide (Calibrator Set) paliperidone, quetiapine, risperidone, ziprasidone ■ Analytes: Order no. Description Quantity Ethylglucuronide, ethylsulfate 9708 ClinCal® Serum Calibrator, lyophil., for Psychoactive Drugs TDM3 5 x 5 ml Order no. Description Quantity

MS8113 ClinCal® Serum Calibrator Set, lyophil., for Ethylglucuronide (Level 0 - 3) 4 x 1 x 1 ml ■ Analytes: Amitriptyline, clomipramine, clozapine, desipramine, desmethylclozapine, doxepin, imipramine, maprotiline, norclomipramine, nordoxepin, nortriptyline, trimipramine Homocysteine (Calibrator Set) Order no. Description Quantity ■ Analytes: 9711 ClinCal® Serum Calibrator, lyophil., for Psychoactive Drugs TDM4 5 x 5 ml See title Order no. Description Quantity ■ Analytes:

MS2013 ClinCal® Serum Calibrator Set, lyophil., for Homocysteine (Level 0 - 3) 4 x 1 x 1 ml Aripiprazole, bupropion, citalopram, dehydro-aripiprazole, desmethylfluoxetine, desmethylmirtazapine, desmethylsertraline, O-desmethylvenlafaxine, duloxetine, erythro-dihydro-bupropion, fluoxetine, fluvoxamine, hydroxybupropion, mianserin, mirtazapine, paroxetine, sertindole, sertraline, Metanephrines (Calibrator Set) threo-dihydro-bupropion, venlafaxine ■ Analytes: Order no. Description Quantity Metanephrine, 3-methoxytyramine, normetanephrine 9717 ClinCal® Serum Calibrator, lyophil., for Psychoactive Drugs TDM6 5 x 5 ml Order no. Description Quantity

MS11013 ClinCal® Serum Calibrator Set, lyophil., for Metanephrines (Level 0 - 4) 5 x 1 x 3 ml Steroids (Calibrator Set) ■ Analytes: Methylmalonic Acid (Calibrator Set) Androstenedione, cortisol, dehydroepiandrosterone (DHEAS), 11-deoxycortisol, 21-deoxycortisol, ■ Analytes: 17-hydroxy-progesterone, 21-hydroxy-progesterone, testosterone See title Order no. Description Quantity Order no. Description Quantity MS12013 ClinCal® Serum Calibrator Set, lyophil., for Steroids (Level 0 - 6) 7 x 1 x 2 ml

MS5013 ClinCal® Serum Calibrator Set, lyophil., for Methylmalonic Acid (Level 0 - 3) 4 x 1 x 2 ml ® ClinCal

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Product Survey ClinCal® Whole Blood Calibrators, Lyophilised / Ready for Use:

Hemoglobin A1c Trace Elements ■ Analytes: ■ Analytes: See title Ag, Al, As, Au, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Fluoride, Hg, Iodid, Li, Mg, Mo, Mn, Ni, Pd, Pt, Order no. Description Quantity

Sb, Se, Sn, Ti, Tl, V, Zn 11011 ClinTest® Reference Standard, ready for use, for HbA1c 10 x 5 ml Order no. Description Quantity

9982 ClinCal® Serum Calibrator, lyophil., for Trace Elements 5 x 3 ml Hemoglobins F / A2 ■ Analytes: Tricyclic Antidepressants (Calibrator Set) Hemoglobin F, hemoglobin A2 ■ Analytes: Order no. Description Quantity

Amitriptyline, clomipramine, clozapine, desipramine, desmethylclozapine, doxepin, imipramine, 13113 ClinCal® Hemolysate Calibrator, ready for use, for Hemoglobins F / A2 5 x 3 ml maprotiline, norclomipramine, nordoxepin, nortrimipramine, nortriptyline, protriptyline, trimipramine Order no. Description Quantity MS9113 ClinCal® Serum Calibrator Set, lyophil., for Tricyclic Antidepressants (Level 0 - 3) 4 x 1 x 1 ml Homocysteine (Calibrator Set, DBS) ■ Analytes: See title Vitamins A and E Order no. Description Quantity ■ Analytes: MS2113 ClinCal® Dried Blood Spot Calibrator Set (DBS), for Homocysteine (Level 0 - 3) 4 x 1 x 3 spots See title Order no. Description Quantity 22013 ClinCal® Serum Calibrator, lyophil., for Vitamins A and E 1 x 3 ml Immunosuppressants (Single Point / Calibrator Set) ■ Analytes: Cyclosporine A, everolimus, sirolimus, tacrolimus Vitamin B6 Order no. Description Quantity ■ Analytes: 9033 ClinCal® Whole Blood Calibrator Set, lyophil., for Immunosuppressants (Level 0 - 3) 4 x 1 x 2 ml

Pyridoxal, pyridoxal-5-phosphate (PLP) 9933 ClinCal® Whole Blood Calibrator Set, lyophil., for Immunosuppressants (Level 0 - 6) 7 x 1 x 2 ml

Order no. Description Quantity 9028 ClinCal® Whole Blood Calibrator, lyophil., for Immunosuppressants (Level 7) 2 x 2 ml

26013 ClinCal® Serum Calibrator, lyophil., for Vitamin B6 1 x 3 ml

Trace Elements Vitamin C ■ Analytes: ■ Analytes: Ag, As, Cd, Co, Cr, Cu, Hg, K, Mg, Mn, Ni, Pb, Pd, Pt, Se, Tl, Zn See title Order no. Description Quantity

Order no. Description Quantity 9943 ClinCal® Whole Blood Calibrator, lyophil., for Trace Elements 5 x 5 ml

28013 ClinCal® Serum Calibrator, lyophil., for Vitamin C 5 x 0.5 ml

Vitamins B1, B2, B6 25-OH Vitamin D2 / D3 (Single Point / Calibrator Set) ■ Analytes: ■ Analytes: Flavin adenine dinucleotide (FAD), pyridoxal, pyridoxal-5-phosphate (PLP), thiaminepyrophosphate (TPP) 25-Hydroxy-vitamin D2, 25-hydroxy-vitamin D3 Order no. Description Quantity

Order no. Description Quantity 24513 ClinCal® Whole Blood Calibrator, lyophil., for Vitamins B1, B2 and B6 5 x 2 ml

35013 ClinCal® Serum Calibrator, lyophil., for 25-OH Vitamin D2 / D3 (single point) 5 x 2 ml ® MS7013 ClinCal® Serum Calibrator Set, lyophil., for 25-OH Vitamin D2 / D3 (Level 0 - 3) 4 x 1 x 1 ml ClinCal

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Quality Assurance

ClinChek® Controls

Analyte Survey ...... 212 - 229

Product Survey Urine Controls ...... 230 - 232 Plasma Controls ...... 232 - 235 Serum Controls ...... 235 - 240 Whole Blood Controls ...... 240 - 241 ®

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With ClinChek® Control Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinChek® Control Order No. Page Analyte Matrix ClinChek® Control Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Acetylcarnitine (C2-Carnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Ascorbic Acid (Vitamin C) ● ClinChek® Vitamin C 28080-28082 239

Alanine ● ClinChek® Amino Acids 10280-10282 232 Asialotransferrin ● ClinChek® CDT 21080-21082 237 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Asparagine ● ClinChek® Amino Acids 10280-10282 232 Alprazolam ● ClinChek® Benzodiazepines MS6082 237 Aspartic acid ● ClinChek® Amino Acids 10280-10282 232 Aluminium ● ClinChek® Trace Elements 8847-8849 232 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 ● 8883-8885 235 ● 8880-8882 239 Atazanavir ● ClinChek® Antiretrovirals MS4082 236

α-Aminobutyric acid ● ClinChek® Amino Acids 10280-10282 232 Atomoxetine ● ClinChek® Antidepressants MS9482 235

7-Aminoclonazepam ● ClinChek® Benzodiazepines MS6082 237 Barium ● ClinChek® Trace Elements 8847-8849 232 ● 8880-8882 239 7-Aminoflunitrazepam ● ClinChek® Benzodiazepines MS6082 237 Beryllium ● ClinChek® Trace Elements 8847-8849 232 5-ALA (5-Aminolevulinic acid) ● ClinChek® 5-ALA / PBG 17280-17282 230 ● 8883-8885 235 ● ClinChek® Porphyrins 17080-17082 232 ● 8880-8882 239

5-Aminolevulinic acid (5-ALA) ● ClinChek® 5-ALA / PBG 17280-17282 230 Bismuth ● ClinChek® Trace Elements 8883-8885 235 ● ClinChek® Porphyrins 17080-17082 232 ● 8880-8882 239

7-Aminonitrazepam ● ClinChek® Benzodiazepines MS6082 237 Bisphenol A ● ClinChek® Phenolic Compounds 8925 231

Amiodarone ● ClinChek® Amiodarone 20080-20082 235 Blank (Drugfree) ● ClinChek® Drugfree 8850-8850B 237 ● 8851-8851B 237 Amisulpride ● ClinChek® Psychoactive Drugs TDM2 8705 238 ® Br2-CA [3-(2,2-Dibromovinyl)- ● ClinChek Environmental Medicine 8928 231 Amitriptyline ● ClinChek® Psychoactive Drugs TDM4 8711 238 2,2-dimethylcyclopropan- ● ClinChek® Tricyclic Antidepressants MS9182 239 1-carboxylic acid]

Amprenavir ● ClinChek® Antiretrovirals MS4082 236 Bromazepam ● ClinChek® Benzodiazepines MS6082 237

Androstenedione ● ClinChek® Steroids MS12083 239 Bromide ● ClinChek® Antiepileptics 15080-15082 235

Antimony ● ClinChek® Trace Elements 8847-8849 232 Bupropion ● ClinChek® Antidepressants MS9482 235 ● 8883-8885 235 ● ClinChek® Psychoactive Drugs TDM6 8717 238 ● 8880-8882 239 ● 8840-8843 241 Butoxy acetic acid ● ClinChek® Occupational Medicine 8922 231

Arginine ● ClinChek® Amino Acids 10280-10282 232 Butyrylcarnitine (C4-Carnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 C0-Carnitine (Carnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Aripiprazole ● ClinChek® Psychoactive Drugs TDM1 8702 238 ● ClinChek® Psychoactive Drugs TDM6 8717 238 C2-Carnitine (Acetylcarnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240

Arsenic ● ClinChek® Trace Elements 8847-8849 232 C3-Carnitine (Propionylcarnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 ● 8883-8885 235 ● 8880-8882 239 C4-Carnitine (Butyrylcarnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 ● 8840-8843 241 C5-Carnitine (Isovalerylcarnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Arsenic V ● ClinChek® Arsenic Species 8931 230 C5DC-Carnitine (Glutarylcarnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Arsenobetaine ● ClinChek® Arsenic Species 8931 230 C6-Carnitine (Hexanoylcarnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 ®

212 213 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 214

With ClinChek® Control Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinChek® Control Order No. Page Analyte Matrix ClinChek® Control Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

C8-Carnitine (Octanoylcarnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Citalopram ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Psychoactive Drugs TDM1 8702 238 C10-Carnitine (Decanoylcarnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 ● ClinChek® Psychoactive Drugs TDM6 8717 238

C12-Carnitine DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Citrulline ● ClinChek® Amino Acids 10280-10282 232 (Dodecanoylcarnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240

C14-Carnitine DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Clobazam ● ClinChek® Benzodiazepines MS6082 237 (Tetradecanoylcarnitine) Clomethiazole ● ClinChek® Antidepressants MS9482 235 C16-Carnitine DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 (Hexadecanoylcarnitine) Clomipramine ● ClinChek® Psychoactive Drugs TDM4 8711 238 ● ClinChek® Tricyclic Antidepressants MS9182 239 C18-Carnitine DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 (Octadecanoylcarnitine) Clonazepam ● ClinChek® Benzodiazepines MS6082 237

Cadmium ● ClinChek® Trace Elements 8847-8849 232 Clozapine ● ClinChek® Atypical Neuroleptics 40080-40082 233 ● 8883-8885 235 ● ClinChek® Psychoactive Drugs TDM3 8708 238 ● 8880-8882 239 ● ClinChek® Psychoactive Drugs TDM4 8711 238 ● 8840-8843 241 ● ClinChek® Tricyclic Antidepressants MS9182 239

Caffeine ● ClinChek® Antiasthmatics 12080-12082 232 Cobalt ● ClinChek® Trace Elements 8847-8849 232 ● 8883-8885 235 Calcium ● ClinChek® Trace Elements 8840-8843 241 ● 8880-8882 239 ● 8840-8843 241 Carbamazepine ● ClinChek® Antiepileptics 15080-15082 235 ● ClinChek® Antiepileptics 3 14080-14082 236 Coenzyme Q10 (Ubiquinone) ● ClinChek® Coenzyme Q10 31080-31082 234 ● ClinChek® Antiepileptics 5 MS9282 236 Copper ● ClinChek® Trace Elements 8847-8849 232 Carbamazepine-diol ● ClinChek® Antiepileptics 5 MS9282 236 ● 8883-8885 235 ● 8880-8882 239 Carbamazepine-epoxide ● ClinChek® Antiepileptics 15080-15082 235 ● 8840-8843 241 ● ClinChek® Antiepileptics 3 14080-14082 236 ● ClinChek® Antiepileptics 5 MS9282 236 Coproporphyrin I ● ClinChek® Porphyrins 17080-17082 232

Carbohydrate deficient ● ClinChek® CDT 21080-21082 237 Coproporphyrin III ● ClinChek® Porphyrins 17080-17082 232 transferrin (CDT) Cortisol ● ClinChek® Steroids MS12083 239 Carnitine (C0-Carnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Cotinine ● ClinChek® Nicotine and Metabolites MS3080-3083 231 β-Carotene, all-trans ● ClinChek® β-Carotene 30080-30082 233 o-Cresol ● ClinChek® Phenolic Compounds 8925 231 CDT (Carbohydrate ● ClinChek® CDT 21080-21082 237 deficient transferrin) Cyclosporine A ● ClinChek® Immunosuppressants 8903 241 ● 8830-8833 241 Chlordiazepoxide ● ClinChek® Benzodiazepines MS6082 237 Darunavir ● ClinChek® Antiretrovirals MS4082 236 Chromium ● ClinChek® Trace Elements 8847-8849 232 ● 8883-8885 235 Decanoylcarnitine (C10-Carnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 ● 8880-8882 239 ● 8840-8843 241 Dehydro-Aripiprazole ● ClinChek® Psychoactive Drugs TDM1 8702 238 ● ClinChek® Psychoactive Drugs TDM6 8717 238 ® cis-Cl2-CA [cis-3- ● ClinChek Environmental Medicine 8928 231 (2,2-Dichlorovinyl)- Dehydroepiandrosterone (DHEAS) ● ClinChek® Steroids MS12083 239 2,2-dimethylcyclopropan- 1-carboxylic acid] Demoxepam ● ClinChek® Benzodiazepines MS6082 237 ®

214 215 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 216

With ClinChek® Control Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinChek® Control Order No. Page Analyte Matrix ClinChek® Control Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

11-Deoxycorticosterone ● ClinChek® Steroids MS12083 239 Dodecanoylcarnitine DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 (21-Hydroxy-Progesterone) (C12-Carnitine)

11-Deoxycortisol ● ClinChek® Steroids MS12083 239 Dopamine ● ClinChek® Biogenic Amines 8820-8822 230 ● 8809-8811 233 21-Deoxycortisol ● ClinChek® Steroids MS12083 239 ● ClinChek® Catecholamines (FD) 2180-2182 230

Desalkylflurazepam ● ClinChek® Benzodiazepines MS6082 237 Dosulepin ● ClinChek® Antidepressants MS9482 235

Desethylamiodarone ● ClinChek® Amiodarone 20080-20082 235 Doxepin ● ClinChek® Psychoactive Drugs TDM4 8711 238 ● ClinChek® Tricyclic Antidepressants MS9182 239 Desipramine ● ClinChek® Psychoactive Drugs TDM4 8711 238 ● ClinChek® Tricyclic Antidepressants MS9182 239 Duloxetine ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Psychoactive Drugs TDM3 8708 238 Desmethylcitalopram ● ClinChek® Psychoactive Drugs TDM1 8702 238 ● ClinChek® Psychoactive Drugs TDM6 8717 238

Desmethylclozapine ● ClinChek® Atypical Neuroleptics 40080-40082 233 Efavirenz ● ClinChek® Antiretrovirals MS4082 236 (Norclozapine) ● ClinChek® Psychoactive Drugs TDM3 8708 238 ● ClinChek® Psychoactive Drugs TDM4 8711 238 Epinephrine ● ClinChek® Biogenic Amines 8820-8822 230 ● 8809-8811 233 Desmethylflunitrazepam ● ClinChek® Benzodiazepines MS6082 237 ● ClinChek® Catecholamines (FD) 2180-2182 230 (Norflunitrazepam) erythro-Dihydro-Bupropion ● ClinChek® Antidepressants MS9482 235 Desmethylfluoxetine ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Psychoactive Drugs TDM6 8717 238 ● ClinChek® Psychoactive Drugs TDM6 8717 238 Escitalopram ● ClinChek® Psychoactive Drugs TDM2 8705 238 N-Desmethylmethsuximide ● ClinChek® Antiepileptics 15080-15082 235 (NDMS) ● ClinChek® Antiepileptics 4 14180-14182 236 Estazolam ● ClinChek® Benzodiazepines MS6082 237 ● ClinChek® Antiepileptics 5 MS9282 236 Ethosuximide ● ClinChek® Antiepileptics 15080-15082 235 Desmethylmirtazapine ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Antiepileptics 3 14080-14082 236 ● ClinChek® Psychoactive Drugs TDM2 8705 238 ● ClinChek® Antiepileptics 5 MS9282 236 ● ClinChek® Psychoactive Drugs TDM6 8717 238 Ethoxy acetic acid ● ClinChek® Occupational Medicine 8922 231 Desmethylolanzapine ● ClinChek® Atypical Neuroleptics 40080-40082 233 ● ClinChek® Psychoactive Drugs TDM3 8708 238 Ethylglucuronide ● ClinChek® Ethylglucuronide MS8080-8083 231 ● MS8180-8182 237 Desmethylsertraline ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Psychoactive Drugs TDM6 8717 238 Ethylsulfate ● ClinChek® Ethylglucuronide MS8080-8083 231 ● MS8180-8182 237 O-Desmethylvenlafaxine ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Psychoactive Drugs TDM1 8702 238 Etravirine ● ClinChek® Antiretrovirals MS4082 236 ● ClinChek® Psychoactive Drugs TDM2 8705 238 ● ClinChek® Psychoactive Drugs TDM6 8717 238 Everolimus ● ClinChek® Immunosuppressants 8903 241 ● 8830-8833 241 DHEAS (Dehydroepiandrosterone) ● ClinChek® Steroids MS12083 239 FAD (Flavin adenine dinucleotide, ● ClinChek® Vitamins 8874-8876 241 Diazepam ● ClinChek® Benzodiazepines MS6082 237 Vitamin B2)

Dimethylarsinic acid ● ClinChek® Arsenic Species 8931 230 Felbamate ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Antiepileptics 4 14180-14182 236 Diphenylhydantoin (Phenytoin) ● ClinChek® Antiepileptics 15080-15082 235 ● ClinChek® Antiepileptics 5 MS9282 236 ● ClinChek® Antiepileptics 5 MS9282 236 Flavin adenine dinucleotide (FAD, ● ClinChek® Vitamins 8874-8876 241 Disialotransferrin ● ClinChek® CDT 21080-21082 237 Vitamin B2) ®

216 217 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 218

With ClinChek® Control Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinChek® Control Order No. Page Analyte Matrix ClinChek® Control Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Fluconazole ● ClinChek® Antimycotics 8839 233 Hemoglobin F (HbF) ● ClinChek® Hemoglobins F / A2 13182 241 ● ClinChek® Hemoglobins F / A2 / S 13183 241 Flunitrazepam ● ClinChek® Benzodiazepines MS6082 237 Hemoglobin S (HbS) ● ClinChek® Hemoglobins F / A2 / S 13183 241 Fluoride ● ClinChek® Trace Elements 8847-8849 232 ● 8883-8885 235 Hemoglobin, free ● ClinChek® Free Hemoglobin 8812-16 240 ● 8880-8882 239 ● ClinChek® Free Hemoglobin (low) 8912-16 240

Fluoxetine ● ClinChek® Antidepressants MS9482 235 Heptacarboxyporphyrin I ● ClinChek® Porphyrins 17080-17082 232 ● ClinChek® Psychoactive Drugs TDM6 8717 238 Hexacarboxyporphyrin Iab + lac ● ClinChek® Porphyrins 17080-17082 232 Flurazepam ● ClinChek® Benzodiazepines MS6082 237 Hexadecanoylcarnitine DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Fluvoxamine ● ClinChek® Antidepressants MS9482 235 (C16-Carnitine) ● ClinChek® Psychoactive Drugs TDM6 8717 238 Hexanoylcarnitine (C6-Carnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Free hemoglobin ● ClinChek® Free Hemoglobin 8812-8816 240 ● ClinChek® Free Hemoglobin (low) 8912-8916 240 Hexasialotransferrin ● ClinChek® CDT 21080-21082 237

Gabapentine ● ClinChek® Antiepileptics 2 15282 235 5-HIAA ● ClinChek® Biogenic Amines 8820-8822 230 ● ClinChek® Antiepileptics 5 MS9282 236 (5-Hydroxyindoleacetic acid)

Glutamic acid ● ClinChek® Amino Acids 10280-10282 232 Hippuric acid ● ClinChek® Occupational Medicine 8922 231 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Histidine ● ClinChek® Amino Acids 10280-10282 232 Glutamine ● ClinChek® Amino Acids 10280-10282 232 Homocysteine ● ClinChek® Homocysteine 23080-23082 234 Glutarylcarnitine (C5DC-Carnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 DBS MS2182 241

Glutathione ❍ ClinChek® Glutathione 33080-33082 xxx Homovanillic acid (HVA) ● ClinChek® Biogenic Amines 8820-8822 230

Glycine ● ClinChek® Amino Acids 10280-10282 232 HVA (Homovanillic acid) ● ClinChek® Biogenic Amines 8820-8822 230 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 α-Hydroxyalprazolam ● ClinChek® Benzodiazepines MS6082 237 Gold ● ClinChek® Trace Elements 8847-8849 232 ● 8880-8882 235 3-Hydroxybromazepam ● ClinChek® Benzodiazepines MS6082 237 ● 8880-8882 239 Hydroxybupropion ● ClinChek® Antidepressants MS9482 235 Haloperidol ● ClinChek® Psychoactive Drugs TDM3 8708 238 ● ClinChek® Psychoactive Drugs TDM6 8717 238

HbA1c (Hemoglobin A1c) ● ClinChek® Hemoglobin A1c 11080-11082 240 10-Hydroxy-Carbamazepine ● ClinChek® Antiepileptics 15080-15082 235 ● ClinChek® Antiepileptics 2 15282 235 HbA2 (Hemoglobin A2) ● ClinChek® Hemoglobins F / A2 13182 241 ● ClinChek® Antiepileptics 3 14080-14082 236 ● ClinChek® Hemoglobins F / A2 / S 13183 241 ● ClinChek® Antiepileptics 5 MS9282 236 ● ClinChek® Psychoactive Drugs TDM1 8702 238 HbF (Hemoglobin F) ● ClinChek® Hemoglobins F / A2 13182 241 ● ClinChek® Hemoglobins F / A2 / S 13183 241 3-Hydroxycotinine ● ClinChek® Nicotine and Metabolites MS3080-3083 231

HbS (Hemoglobin S) ● ClinChek® Hemoglobins F / A2 / S 13183 241 5-Hydroxyindoleacetic acid ● ClinChek® Biogenic Amines 8820-8822 230 (5-HIAA) Hemoglobin A1c (HbA1c) ● ClinChek® Hemoglobin A1c 11080-11082 240 Hydroxy-Itraconazole ● ClinChek® Antimycotics 8839 233 Hemoglobin A2 (HbA2) ● ClinChek® Hemoglobins F / A2 13182 241 ● ClinChek® Hemoglobins F / A2 / S 13183 241 α-Hydroxymidazolam ● ClinChek® Benzodiazepines MS6082 237 ®

218 219 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 220

With ClinChek® Control Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinChek® Control Order No. Page Analyte Matrix ClinChek® Control Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

4-Hydroxyproline ● ClinChek® Amino Acids 10280-10282 232 Leucine ● ClinChek® Amino Acids 10280-10282 232 ● ClinChek® Biogenic Amines 8820-8822 230 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240

1-Hydroxypyrene ● ClinChek® Phenolic Compounds 8925 231 Levetiracetam (Keppra®) ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Antiepileptics 5 MS9282 236 9-Hydroxy-Risperidone ● ClinChek® Psychoactive Drugs TDM3 8708 238 ● ClinChek® Levetiracetam 15580-15582 236 (Paliperidone) ● ClinChek® Risperidone, Paliperidone 40180-40182 233 Lithium ● ClinChek® Trace Elements 8883-8885 235 α-Hydroxytriazolam ● ClinChek® Benzodiazepines MS6082 237 ● 8880-8882 239

25-Hydroxyvitamin D2 ● ClinChek® 25-OH Vitamins D2 / D3 35080-35082 239 Lopinavir ● ClinChek® Antiretrovirals MS4082 236 ● MS7080-7082 239 Lorazepam ● ClinChek® Benzodiazepines MS6082 237 25-Hydroxyvitamin D3 ● ClinChek® 25-OH Vitamins D2 / D3 35080-35082 239 ● MS7080-7082 239 Lormetazepam ● ClinChek® Benzodiazepines MS6082 237

Imipramine ● ClinChek® Psychoactive Drugs TDM4 8711 238 Lysine ● ClinChek® Amino Acids 10280-10282 232 ● ClinChek® Tricyclic Antidepressants MS9182 239 Magnesium ● ClinChek® Trace Elements 8847-8849 232 Indinavir ● ClinChek® Antiretrovirals MS4082 236 ● 8883-8885 235 ● 8880-8882 239 Iodide ● ClinChek® Trace Elements 8847-8849 232 ● 8840-8843 241 ● 8883-8885 235 ● 8880-8882 239 Malondialdehyde ● ClinChek® Malondialdehyde 32080-32082 234

Iron ● ClinChek® Trace Elements 8847-8849 232 Mandelic acid ● ClinChek® Occupational Medicine 8922 231 ● 8883-8885 235 ● 8880-8882 239 Manganese ● ClinChek® Trace Elements 8847-8849 232 ● 8840-8843 241 ● 8883-8885 235 ● 8880-8882 239 Isoleucine ● ClinChek® Amino Acids 10280-10282 232 ● 8840-8843 241

allo-Isoleucine ● ClinChek® Amino Acids 10280-10282 232 Maprotiline ● ClinChek® Psychoactive Drugs TDM4 8711 238 ● ClinChek® Tricyclic Antidepressants MS9182 239 Isovalerylcarnitine (C5-Carnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Maraviroc ● ClinChek® Antiretrovirals MS4082 236 Itraconazole ● ClinChek® Antimycotics 8839 233 MBzP (Mono-benzylphthalate) ● ClinChek® Environmental Medicine 8928 231 Keppra® (Levetiracetam) ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Antiepileptics 5 MS9282 236 Medazepam ● ClinChek® Benzodiazepines MS6082 237 ● ClinChek® Levetiracetam 15580-15582 236 5-OH-MEHP [Mono-(2-ethyl- ● ClinChek® Environmental Medicine 8928 231 Lacosamide ● ClinChek® Antiepileptics 2 15282 235 5-hydroxyhexyl) phthalate] ● ClinChek® Antiepileptics 4 14180-14182 236 ● ClinChek® Antiepileptics 5 MS9282 236 5-oxo-MEHP [Mono-(2-ethyl- ● ClinChek® Environmental Medicine 8928 231 5-oxohexyl) phthalate] Lamotrigine ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Antiepileptics 3 14080-14082 236 5-cx-MEPP [Mono-(2-ethyl- ● ClinChek® Environmental Medicine 8928 231 ● ClinChek® Antiepileptics 5 MS9282 236 5-carboxypentyl) phthalate] ● ClinChek® Lamotrigine a. Sulthiame 15180-15182 234 ● ClinChek® Psychoactive Drugs TDM1 8702 238 Mercury ● ClinChek® Trace Elements 8847-8849 232 ● 8883-8885 235 Lead ● ClinChek® Trace Elements 8847-8849 232 ● 8880-8882 239 ● 8840-8843 241 ● 8840-8843 241 ®

220 221 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 222

With ClinChek® Control Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinChek® Control Order No. Page Analyte Matrix ClinChek® Control Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Metanephrine ● ClinChek® Biogenic Amines 8820-8822 230 2-Naphthol ● ClinChek® Phenolic Compounds 8925 231 ● ClinChek® Metanephrines MS11080-11082 237 NDMS ● ClinChek® Antiepileptics 15080-15082 235 Methionine ● ClinChek® Amino Acids 10280-10282 232 (N-Desmethylmethsuximide) ● ClinChek® Antiepileptics 4 14180-14182 236 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 ● ClinChek® Antiepileptics 5 MS9282 236

Methoxy acetic acid ● ClinChek® Occupational Medicine 8922 231 Nelfinavir ● ClinChek® Antiretrovirals MS4082 236

3-Methoxytyramine ● ClinChek® Biogenic Amines 8820-8822 230 Nevirapine ● ClinChek® Antiretrovirals MS4082 236 ● ClinChek® Metanephrines MS11080-11082 237 Nickel ● ClinChek® Trace Elements 8847-8849 232 Methylenedianiline ● ClinChek® Occupational Medicine 8922 231 ● 8883-8885 235 ● 8880-8882 239 N-Methylformamide ● ClinChek® Occupational Medicine 8922 231 ● 8840-8843 241

m/p-Methyl-hippuric acid ● ClinChek® Occupational Medicine 8922 231 Nicotine ● ClinChek® Nicotine and Metabolites MS3080-3083 231

o-Methyl-hippuric acid ● ClinChek® Occupational Medicine 8922 231 Nitrazepam ● ClinChek® Benzodiazepines MS6082 237

1-Methyl-histidine ● ClinChek® Amino Acids 10280-10282 232 Norclobazam ● ClinChek® Benzodiazepines MS6082 237

3-Methyl-histidine ● ClinChek® Amino Acids 10280-10282 232 Norclomipramine ● ClinChek® Psychoactive Drugs TDM4 8711 238 ● ClinChek® Tricyclic Antidepressants MS9182 239 Methylmalonic acid ● ClinChek® Methylmalonic Acid MS5080-5082 238 Norclozapine ● ClinChek® Atypical Neuroleptics 40080-40082 233 Mianserin ● ClinChek® Antidepressants MS9482 235 (Desmethylclozapine) ● ClinChek® Tricyclic Antidepressants MS9182 239 ● ClinChek® Psychoactive Drugs TDM6 8717 238 ● ClinChek® Psychoactive Drugs TDM3 8708 238 ● ClinChek® Psychoactive Drugs TDM4 8711 238 MiBP (Mono-iso-butylphthalate) ● ClinChek® Environmental Medicine 8928 231 Nordiazepam ● ClinChek® Benzodiazepines MS6082 237 Midazolam ● ClinChek® Benzodiazepines MS6082 237 Nordoxepin ● ClinChek® Psychoactive Drugs TDM4 8711 238 Milnacipran ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Tricyclic Antidepressants MS9182 239

Mirtazapine ● ClinChek® Antidepressants MS9482 235 Norepinephrine ● ClinChek® Biogenic Amines 8820-8822 230 ● ClinChek® Psychoactive Drugs TDM2 8705 238 ● 8809-8811 233 ● ClinChek® Psychoactive Drugs TDM6 8717 238 ● ClinChek® Catecholamines (FD) 2180-2182 230

MnBP (Mono-n-butylphthalate) ● ClinChek® Environmental Medicine 8928 231 Norflunitrazepam ● ClinChek® Benzodiazepines MS6082 237 (Desmethylflunitrazepam) Moclobemide ● ClinChek® Antidepressants MS9482 235 Normetanephrine ● ClinChek® Biogenic Amines 8820-8822 230 Molybdenum ● ClinChek® Trace Elements 8847-8849 232 ● ClinChek® Metanephrines MS11080-11082 237 ● 8883-8885 235 ● 8880-8882 239 Norolanzapine ● ClinChek® Psychoactive Drugs TDM3 8708 238 ● 8840-8843 241 (Desmethylolanzapine)

Monomethylarsonic acid ● ClinChek® Arsenic Species 8931 230 Norquetiapine ● ClinChek® Psychoactive Drugs TDM1 8702 238

Monosialotransferrin ● ClinChek® CDT 21080-21082 237 Nortrimipramine ● ClinChek® Tricyclic Antidepressants MS9182 239

t,t-Muconic acid ● ClinChek® Occupational Medicine 8922 231 Nortriptyline ● ClinChek® Psychoactive Drugs TDM4 8711 238 ● ClinChek® Tricyclic Antidepressants MS9182 239 Mycophenolic acid ● ClinChek® Mycophenolic Acid 29080-29083 234 Octadecanoylcarnitine DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 1-Naphthol ● ClinChek® Phenolic Compounds 8925 231 (C18-Carnitine) ®

222 223 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 224

With ClinChek® Control Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinChek® Control Order No. Page Analyte Matrix ClinChek® Control Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Octanoylcarnitine (C8-Carnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Phenylalanine ● ClinChek® Amino Acids 10280-10282 232 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 Olanzapine ● ClinChek® Atypical Neuroleptics 40080-40082 233 ● ClinChek® Aromatic Amino Acids 10080-10082 233 ● ClinChek® Psychoactive Drugs TDM3 8708 238 Phenylethylmalonamide (PEMA) ● ClinChek® Antiepileptics 15080-15082 235 Opipramol ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Antiepileptics 5 MS9282 236

Ornithine ● ClinChek® Amino Acids 10280-10282 232 Phenylglyoxylic acid ● ClinChek® Occupational Medicine 8922 231 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 S-Phenylmercapturic acid ● ClinChek® Occupational Medicine 8922 231 ortho-Cresol ● ClinChek® Phenolic Compounds 8925 231 Phenytoin (Diphenylhydantoin) ● ClinChek® Antiepileptics 15080-15082 235 Oxazepam ● ClinChek® Benzodiazepines MS6082 237 ● ClinChek® Antiepileptics 3 14080-14082 236 ● ClinChek® Antiepileptics 5 MS9282 236 Oxcarbazepine ● ClinChek® Antiepileptics 15080-15082 235 ● ClinChek® Antiepileptics 2 15282 235 Phosphoserine ● ClinChek® Amino Acids 10280-10282 232 ● ClinChek® Antiepileptics 3 14080-14082 236 ● ClinChek® Antiepileptics 5 MS9282 236 Platinum ● ClinChek® Trace Elements 8847-8849 232 ● 8883-8885 235 Paliperidone ● ClinChek® Psychoactive Drugs TDM3 8708 238 ● 8880-8882 239 (9-Hydroxy-Risperidone) ● ClinChek® Risperidone, Paliperidone 40180-40182 233 ● 8840-8843 241

Palladium ● ClinChek® Trace Elements 8847-8849 232 Porphobilinogen (PBG) ● ClinChek® 5-ALA / PBG 17280-17282 230 ● 8883-8885 235 ● ClinChek® Porphyrins 17080-17082 232 ● 8880-8882 239 Posaconazole ● ClinChek® Antimycotics 8839 233 Paroxetine ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Psychoactive Drugs TDM6 8717 238 Potassium ● ClinChek® Trace Elements 8840-8843 241

3-PBA (3-Phenoxybenzoic acid) ● ClinChek® Environmental Medicine 8928 231 Prazepam ● ClinChek® Benzodiazepines MS6082 237

PBG (Porphobilinogen) ● ClinChek® 5-ALA / PBG 17280-17282 230 Pregabaline ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Porphyrins 17080-17082 232 ● ClinChek® Antiepileptics 5 MS9282 236

PEMA (Phenylethylmalonamide) ● ClinChek® Antiepileptics 15080-15082 235 Primidone ● ClinChek® Antiepileptics 15080-15082 235 ● ClinChek® Antiepileptics 5 MS9282 236 ● ClinChek® Antiepileptics 3 14080-14082 236 ● ClinChek® Antiepileptics 5 MS9282 236 Pentacarboxyporphyrin I ● ClinChek® Porphyrins 17080-17082 232 17-Hydroxy-Progesterone ● ClinChek® Steroids MS12083 239 Pentachlorophenol ● ClinChek® Phenolic Compounds 8925 231 21-Hydroxy-Progesterone ● ClinChek® Steroids MS12083 239 Pentasialotransferrin ● ClinChek® CDT 21080-21082 237 (11-Doxycorticosterone)

Perampanel ● ClinChek® Antiepileptics 2 15282 235 Proline ● ClinChek® Amino Acids 10280-10282 232 ● ClinChek® Antiepileptics 5 MS9282 236 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240

Perazine ● ClinChek® Psychoactive Drugs TDM1 8702 238 Propionylcarnitine (C3-Carnitine) DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240

Phenobarbital ● ClinChek® Antiepileptics 15080-15082 235 Protriptyline ● ClinChek® Tricyclic Antidepressants MS9182 239 ● ClinChek® Antiepileptics 3 14080-14082 236 ● ClinChek® Antiepileptics 5 MS9282 236 Pyridoxal (Vitamin B6) ● ClinChek® Vitamins 8870-8873 240 ● 8874-8876 241 Phenol ● ClinChek® Phenolic Compounds 8925 231 Pyridoxal-5-phosphate ● ClinChek® Vitamins 8870-8873 240 3-Phenoxybenzoic acid (3-PBA) ● ClinChek® Environmental Medicine 8928 231 (Vitamin B6) ● 8874-8876 241 ®

224 225 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 226

With ClinChek® Control Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinChek® Control Order No. Page Analyte Matrix ClinChek® Control Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Quetiapine ● ClinChek® Atypical Neuroleptics 40080-40082 233 Sulthiame ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Psychoactive Drugs TDM1 8702 238 ● ClinChek® Antiepileptics 3 14080-14082 236 ● ClinChek® Psychoactive Drugs TDM2 8705 238 ● ClinChek® Antiepileptics 5 MS9282 236 ● ClinChek® Psychoactive Drugs TDM3 8708 238 ● ClinChek® Lamotrigine a. Sulthiame 15180-15182 234

Raltegravir ● ClinChek® Antiretrovirals MS4082 236 Tacrolimus ● ClinChek® Immunosuppressants 8830-8833 241 ● 8903 241 Reboxetine ● ClinChek® Antidepressants MS9482 235 Taurine ● ClinChek® Amino Acids 10280-10282 232 Retigabine ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Antiepileptics 5 MS9282 236 Temazepam ● ClinChek® Benzodiazepines MS6082 237

Retinol, all-trans (Vitamin A) ● ClinChek® Vitamins 8870-8873 240 Testosterone ● ClinChek® Steroids MS12083 239

Rilpivirine ● ClinChek® Antiretrovirals MS4082 236 Tetradecanoylcarnitine DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 (C14-Carnitine) Risperidone ● ClinChek® Psychoactive Drugs TDM3 8708 238 ● ClinChek® Risperidone, Paliperidone 40180-40182 233 Tetrasialotransferrin ● ClinChek® CDT 21080-21082 237

Ritalinic acid ● ClinChek® Antidepressants MS9482 235 Tetrazepam ● ClinChek® Benzodiazepines MS6082 237

Ritonavir ● ClinChek® Antiretrovirals MS4082 236 Thallium ● ClinChek® Trace Elements 8847-8849 232 ● 8883-8885 235 Rufinamide ● ClinChek® Antiepileptics 2 15282 235 ● 8880-8882 239 ● ClinChek® Antiepileptics 4 14180-14182 236 ● 8840-8843 241 ● ClinChek® Antiepileptics 5 MS9282 236 Theobromine ● ClinChek® Antiasthmatics 12080-12082 232 Saquinavir ● ClinChek® Antiretrovirals MS4082 236 Theophylline ● ClinChek® Antiasthmatics 12080-12082 232 Selenium ● ClinChek® Trace Elements 8847-8849 232 ● ClinChek® Antiepileptics 5 MS9282 236 ● 8883-8885 235 ● 8880-8882 239 Thiaminepyrophosphate (TPP, ● ClinChek® Vitamins 8874-8876 241 ● 8840-8843 241 Vitamin B1)

Serine ● ClinChek® Amino Acids 10280-10282 232 threo-Dihydro-Bupropion ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Psychoactive Drugs TDM6 8717 238 Serotonin ● ClinChek® Biogenic Amines 8820-8822 230 ● 8809-8811 233 Threonine ● ClinChek® Amino Acids 10280-10282 232

Sertindole ● ClinChek® Psychoactive Drugs TDM6 8717 238 Tiagabine ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Antiepileptics 5 MS9282 236 Sertraline ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Psychoactive Drugs TDM6 8717 238 Tin ● ClinChek® Trace Elements 8847-8849 232 ● 8883-8885 235 Silver ● ClinChek® Trace Elements 8883-8885 235 ● 8880-8882 239 ● 8880-8882 239 ● 8840-8843 241 ● 8840-8843 241 Tipranavir ● ClinChek® Antiretrovirals MS4082 236 Sirolimus ● ClinChek® Immunosuppressants 8830-8833 241 ● 8903 241 Titanium ● ClinChek® Trace Elements 8883-8885 235 ● 8880-8882 239 Sodium ● ClinChek® Trace Elements 8840-8843 241 α-Tocopherol (Vitamin E) ● ClinChek® Vitamins 8870-8873 240 Stiripentol ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Antiepileptics 5 MS9282 236 Topiramat ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Antiepileptics 5 MS9282 236 ®

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With ClinChek® Control Materials the following analytes Analyte Survey are available:

Analyte Matrix ClinChek® Control Order No. Page Analyte Matrix ClinChek® Control Order No. Page

(alphabetical) Urine Plasma Serum Whole ● = available (alphabetical) Urine Plasma Serum Whole ● = available Blood ❍ = in preparation Blood ❍ = in preparation

Total porphyrins ● ClinChek® 5-ALA / PBG 17280-17282 230 Vigabatrine ● ClinChek® Antiepileptics 2 15282 235 ● ClinChek® Porphyrins 17080-17082 232 ● ClinChek® Antiepileptics 5 MS9282 236

TPP (Thiaminepyrophosphate, ● ClinChek® Vitamins 8874-8876 241 Vitamin A (Retinol, all-trans) ● ClinChek® Vitamins 8870-8873 240 Vitamin B1) Vitamin B1 ● ClinChek® Vitamins 8874-8876 241 ® trans-Cl2-CA [trans-3- ● ClinChek Environmental Medicine 8928 231 (2,2-Dichlorovinyl)- Vitamin B2 ● ClinChek® Vitamins 8874-8876 241 2,2-dimethylcyclopropan- 1-carboxylic acid] Vitamin B6 ● ClinChek® Vitamins 8870-8873 240 ● 8874-8876 241 Tranylcypromine ● ClinChek® Antidepressants MS9482 235 Vitamin C ● ClinChek® Vitamin C 28080-28082 239 Trazodone ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Benzodiazepines MS6082 237 Vitamin D2 ● ClinChek® 25-OH Vitamins D2 / D3 35080-35082 239 ● MS7080-7082 239 Triazolam ● ClinChek® Benzodiazepines MS6082 237 Vitamin D3 ● ClinChek® 25-OH Vitamins D2 / D3 35080-35082 239 Trichloroacetic acid ● ClinChek® Occupational Medicine 8922 231 ● MS7080-7082 239

Trimipramine ● ClinChek® Psychoactive Drugs TDM4 8711 238 Vitamin E (α-Tocopherol) ● ClinChek® Vitamins 8870-8873 240 ● ClinChek® Tricyclic Antidepressants MS9182 239 VMA (Vanillylmandelic acid) ● ClinChek® Biogenic Amines 8820-8822 230 Trisialotransferrin ● ClinChek® CDT 21080-21082 237 Voriconazole ● ClinChek® Antimycotics 8839 233 Tryptophane ● ClinChek® Amino Acids 10280-10282 232 ● ClinChek® Aromatic Amino Acids 10080-10082 233 Zaleplon ● ClinChek® Benzodiazepines MS6082 237

Tyrosine ● ClinChek® Amino Acids 10280-10282 232 Zinc ● ClinChek® Trace Elements 8847-8849 232 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 ● 8883-8885 235 ● ClinChek® Aromatic Amino Acids 10080-10082 233 ● 8880-8882 239 ● 8840-8843 241 Ubiquinone (Coenzyme Q10) ● ClinChek® Coenzyme Q10 31080-31082 234 Ziprasidone ● ClinChek® Psychoactive Drugs TDM3 8708 238 Urea ● ClinChek® Amino Acids 10280-10282 232 Zolpidem ● ClinChek® Benzodiazepines MS6082 237 Uroporphyrin I ● ClinChek® Porphyrins 17080-17082 232 Zonisamide ● ClinChek® Antiepileptics 2 15282 235 Valine ● ClinChek® Amino Acids 10280-10282 232 ● ClinChek® Antiepileptics 4 14180-14182 236 DBS ClinChek® Amino Acids a. Acylcarn. MS10182 240 ● ClinChek® Antiepileptics 5 MS9282 236

Valproic acid ● ClinChek® Antiepileptics 15080-15082 235 Zopiclone ● ClinChek® Benzodiazepines MS6082 237 ● ClinChek® Antiepileptics 5 MS9282 236 Zopiclone + ACP ● ClinChek® Benzodiazepines MS6082 237 Vanadium ● ClinChek® Trace Elements 8847-8849 232 ● 8883-8885 235 ● 8880-8882 239

Vanillylmandelic acid (VMA) ● ClinChek® Biogenic Amines 8820-8822 230

Venlafaxine ● ClinChek® Antidepressants MS9482 235 ● ClinChek® Psychoactive Drugs TDM1 8702 238 ● ClinChek® Psychoactive Drugs TDM2 8705 238 ● ClinChek® Psychoactive Drugs TDM6 8717 238 ®

228 229 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 230

Product Survey Environmental Medicine ■ Analytes:

Br2-CA [3-(2,2-dibromovinyl)-2,2-dimethylcyclopropan-1-carboxylic acid],

The analytes listed in the Analyte Survey (see pages 212 - 229) are included in the following cis-Cl2-CA [cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropan-1-carboxylic acid],

® ClinChek Urine, Plasma, Serum, and Whole Blood Controls: trans-Cl2-CA [trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropan-1-carboxylic acid], MBzP [Mono-benzylphthalate], 5-OH-MEHP [Mono-(2-ethyl-5-hydroxyhexyl)phthalate], 5-oxo-MEHP [Mono-(2-ethyl-5-oxohexyl)phthalate], 5-cx-MEPP [Mono-(2-ethyl-5- carboxypentyl)phthalate], MiBP [Mono-iso-butylphthalate], MnBP [Mono-n-butylphthalate], ClinChek® Urine Controls, Lyophilised: 3-PBA [3-phenoxybenzoic acid] Order no. Description Quantity 5-ALA, PBG, Total Porphyrins 8928 ClinChek® Urine Control, lyophil., for Environmental Medicine, Level I, II 2 x 5 x 5 ml ■ Analytes: 5-Aminolevulinic acid (5-ALA), porphobilinogen (PBG), total porphyrins Order no. Description Quantity Ethylglucuronide

17280 ClinChek® Urine Control, lyophil., for 5-ALA, PBG, Level I 10 x 5 ml ■ Analytes:

17281 ClinChek® Urine Control, lyophil., for 5-ALA, PBG, Level II 10 x 5 ml Ethylglucuronide, ethylsulfate

17282 ClinChek® Urine Control, lyophil., for 5-ALA, PBG, Level I, II 2 x 5 x 5 ml Order no. Description Quantity MS8080 ClinChek® Urine Control, lyophil., for Ethylglucuronide, Level I 10 x 1 ml

MS8081 ClinChek® Urine Control, lyophil., for Ethylglucuronide, Level II 10 x 1 ml Arsenic Species MS8082 ClinChek® Urine Control, lyophil., for Ethylglucuronide, Level III 10 x 1 ml ■ Analytes: MS8083 ClinChek® Urine Control, lyophil., for Ethylglucuronide, Level I, II, III 3 x 3 x 1 ml Arsenic V, arsenobetaine, dimethylarsinic acid, monomethylarsonic acid Order no. Description Quantity

8931 ClinChek® Urine Control, lyophil., for Arsenic Species, Level I, II 2 x 5 x 5 ml Nicotine and Metabolites ■ Analytes: Cotinine, 3ʼ-hydroxycotinine, nicotine Biogenic Amines Order no. Description Quantity ■ Analytes: MS3080 ClinChek® Urine Control, lyophil., for Nicotine and Metabolites, Level I 5 x 3 ml Dopamine, epinephrine, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), MS3081 ClinChek® Urine Control, lyophil., for Nicotine and Metabolites, Level II 5 x 3 ml hydroxyproline, metanephrine, 3-methoxytyramine, norepinephrine, normetanephrine, MS3082 ClinChek® Urine Control, lyophil., for Nicotine and Metabolites, Level III 5 x 3 ml serotonin, vanillylmandelic acid (VMA) MS3083 ClinChek® Urine Control, lyophil., for Nicotine and Metabolites, Level I, II, III 3 x 2 x 3 ml Order no. Description Quantity

8820 ClinChek® Urine Control, lyophil., for Biogenic Amines, Level I 10 x 8 ml

8821 ClinChek® Urine Control, lyophil., for Biogenic Amines, Level II 10 x 8 ml Occupational Medicine

8822 ClinChek® Urine Control, lyophil., for Biogenic Amines, Level I, II 2 x 5 x 8 ml ■ Analytes: Butoxy acetic acid, ethoxy acetic acid, hippuric acid, mandelic acid, methoxy acetic acid, methylenedianiline, N-methyl-formamide, m/p-methyl-hippuric acid, o-methyl-hippuric acid, Catecholamines t,t-muconic acid, phenylglyoxylic acid, S-phenylmercapturic acid, trichloroacetic acid ■ Analytes: Order no. Description Quantity Dopamine, epinephrine, norepinephrine 8922 ClinChek® Urine Control, lyophil., for Occupational Medicine, Level I, II 2 x 5 x 5 ml Order no. Description Quantity

2180 ClinChek® Urine Control, lyophil., for Catcholamines (FD), Level I 10 x 5 ml

2181 ClinChek® Urine Control, lyophil., for Catcholamines (FD), Level II 10 x 5 ml Phenolic Compounds

2182 ClinChek® Urine Control, lyophil., for Catcholamines (FD), Level III 2 x 5 x 5 ml ■ Analytes: Bisphenol A, o-cresol, 1-hydroxypyrene, 1-naphthol, 2-naphthol, pentachlorophenol, phenol Order no. Description Quantity

8925 ClinChek® Urine Control, lyophil., for Phenolic Compounds, Level I, II 2 x 5 x 5 ml ®

230 231 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 232

Product Survey Antimycotics ■ Analytes: Fluconazole, hydroxy-itraconazole, itraconazole, posaconazole, voriconazole Porphyrins Order no. Description Quantity ■ Analytes: 8839 ClinChek® Plasma Control, lyophil., for Antimycotics, Level I, II, III 3 x 2 x 1 ml 5-Aminolevulinic acid (5-ALA), coproporphyrin I, coproporphyrin III, heptacarboxyporphyrin I, hexacarboxyporphyrin Iac + Iab, pentacarboxyporphyrin I, porphobilinogen (PBG), total porphyrins, uroporphyrin I Aromatic Amino Acids Order no. Description Quantity ■ Analytes:

17080 ClinChek® Urine Control, lyophil., for Porphyrins, Level I 10 x 5 ml Phenylalanine, tryptophane, tyrosine

17081 ClinChek® Urine Control, lyophil., for Porphyrins, Level II 10 x 5 ml Order no. Description Quantity

17082 ClinChek® Urine Control, lyophil., for Porphyrins, Level I, II 2 x 5 x 5 ml 10080 ClinChek® Plasma Control, lyophil., for Aromatic Amino Acids, Level I 10 x 3 ml 10081 ClinChek® Plasma Control, lyophil., for Aromatic Amino Acids, Level II 10 x 3 ml

10082 ClinChek® Plasma Control, lyophil., for Aromatic Amino Acids, Level I, II 2 x 5 x 3 ml Trace Elements ■ Analytes: Al, As, Au, Ba, Be, Cd, Co, Cr, Cu, Fluoride, Fe, Hg, Iodide, Mg, Mn, Mo, Ni, Pb, Pd, Pt, Atypical Neuroleptics Sb, Se, Sn, Tl, V, Zn ■ Analytes: Order no. Description Quantity Clozapine, desmethylclozapine, desmethylolanzapine, olanzapine, quetiapine

8847 ClinChek® Urine Control, lyophil., for Trace Elements, Level I 10 x 10 ml Order no. Description Quantity

8848 ClinChek® Urine Control, lyophil., for Trace Elements, Level II 10 x 10 ml 40080 ClinChek® Plasma Control, lyophil., for Atypical Neuroleptics, Level I 10 x 3 ml

8849 ClinChek® Urine Control, lyophil., for Trace Elements, Level I, II 2 x 5 x 10 ml 40081 ClinChek® Plasma Control, lyophil., for Atypical Neuroleptics, Level II 10 x 3 ml 40082 ClinChek® Plasma Control, lyophil., for Atypical Neuroleptics, Level I, II 2 x 5 x 3 ml

ClinChek® Plasma Controls, Lyophilised: ■ Analytes: Paliperidone (9-hydroxy-risperidone), risperidone Amino Acids (by Amino Acid Analyser) Order no. Description Quantity ■ Analytes: 40180 ClinChek® Plasma Control, lyophil., for Risperidone, Paliperidone, Level I 10 x 5 ml Alanine, α-aminobutyric acid, arginine, asparagine, aspartic acid, citrulline, glutamic acid, glutamine, 40181 ClinChek® Plasma Control, lyophil., for Risperidone, Paliperidone, Level II 10 x 5 ml glycine, histidine, 4-hydroxyproline, allo-isoleucine, isoleucine, leucine, lysine, methionine, 40182 ClinChek® Plasma Control, lyophil., for Risperidone, Paliperidone, Level I, II 2 x 5 x 5 ml 1-methyl-histidine, 3-methyl-histidine, ornithine, phenylalanine, phosphoserine, proline, serine, taurine, threonine, tryptophane, tyrosine, urea, valine Order no. Description Quantity Biogenic Amines

10280 ClinChek® Plasma Control, lyophil., for Amino Acids (by Amino Acid Analyser), Level I 10 x 3 ml ■ Analytes:

10281 ClinChek® Plasma Control, lyophil., for Amino Acids (by Amino Acid Analyser), Level II 10 x 3 ml Dopamine, epinephrine, norepinephrine, serotonin

10282 ClinChek® Plasma Control, lyophil., for Amino Acids (by Amino Acid Analyser), Level I, II 2 x 5 x 3 ml Order no. Description Quantity 8810 ClinChek® Plasma Control, lyophil., for Biogenic Amines, Level I 10 x 5 ml

8811 ClinChek® Plasma Control, lyophil., for Biogenic Amines, Level II 10 x 5 ml Antiasthmatics 8809 ClinChek® Plasma Control, lyophil., for Biogenic Amines, Level I, II 2 x 5 x 5 ml ■ Analytes: Caffeine, theobromine, theophylline Order no. Description Quantity β-Carotene

12080 ClinChek® Plasma Control, lyophil., for Antiasthmatics, Level I 10 x 3 ml ■ Analytes:

12081 ClinChek® Plasma Control, lyophil., for Antiasthmatics, Level II 10 x 3 ml all-trans-β-carotene

12082 ClinChek® Plasma Control, lyophil., for Antiasthmatics, Level I, II 2 x 5 x 3 ml Order no. Description Quantity 30080 ClinChek® Plasma Control, lyophil., for β-Carotene, Level I 10 x 2 ml

30081 ClinChek® Plasma Control, lyophil., for β-Carotene, Level II 10 x 2 ml

30082 ClinChek® Plasma Control, lyophil., for β-Carotene, Level I, II 2 x 5 x 2 ml ®

232 233 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 234

Product Survey Trace Elements ■ Analytes: Ag, Al, As, Au, Be, Bi, Cd, Co, Cr, Cu, Fe, Fluoride, Hg, Iodide, Li, Mg, Mn, Mo, Coenzyme Q10 Ni, Pd, Pt, Sb, Se, Sn, Ti, Tl, V, Zn ■ Analytes: Order no. Description Quantity Coenzyme Q10 (ubichinone) 8883 ClinChek® Plasma Control, lyophil., for Trace Elements, Level I 10 x 3 ml Order no. Description Quantity 8884 ClinChek® Plasma Control, lyophil., for Trace Elements, Level II 10 x 3 ml

31080 ClinChek® Plasma Control, lyophil., for Coenzyme Q10, Level I 10 x 2 ml 8885 ClinChek® Plasma Control, lyophil., for Trace Elements, Level I, II 2 x 5 x 3 ml

31081 ClinChek® Plasma Control, lyophil., for Coenzyme Q10, Level II 10 x 2 ml

31082 ClinChek® Plasma Control, lyophil., for Coenzyme Q10, Level I, II 2 x 5 x 2 ml ClinChek® Serum Controls, Lyophilised:

Homocysteine Amiodarone ■ Analytes: ■ Analytes: See title Amiodarone, desethylamiodarone Order no. Description Quantity Order no. Description Quantity

23080 ClinChek® Plasma Control, lyophil., for Homocysteine, Level I 10 x 3 ml 20080 ClinChek® Serum Control, lyophil., for Amiodarone, Level I 10 x 3 ml

23081 ClinChek® Plasma Control, lyophil., for Homocysteine, Level II 10 x 3 ml 20081 ClinChek® Serum Control, lyophil., for Amiodarone, Level II 10 x 3 ml

23082 ClinChek® Plasma Control, lyophil., for Homocysteine, Level I, II 2 x 5 x 3 ml 20082 ClinChek® Serum Control, lyophil., for Amiodarone, Level I, II 2 x 5 x 3 ml

Lamotrigine and Sulthiame Antidepressants ■ Analytes: ■ Analytes: See title Atomoxetine, bupropion, citalopram, clomethiazole, desmethylfluoxetine, desmethylmirtazapine, Order no. Description Quantity N-desmethylsertraline, O-desmethylvenlafaxine, dosulepin, duloxetine, erythro-dihydro-bupropion,

15180 ClinChek® Plasma Control, lyophil., for Lamotrigine and Sulthiame, Level I 10 x 3 ml fluoxetine, fluvoxamine, hydroxybupropion, mianserin, milnacipran, mirtazapine, moclobemide,

15181 ClinChek® Plasma Control, lyophil., for Lamotrigine and Sulthiame, Level II 10 x 3 ml opipramol, paroxetine, reboxetine, ritalinic acid, sertraline, threo-dihydro-bupropion, tranylcypromine,

15182 ClinChek® Plasma Control, lyophil., for Lamotrigine and Sulthiame, Level I, II 2 x 5 x 3 ml trazodone, venlafaxine Order no. Description Quantity

MS9482 ClinChek® Serum Control, lyophil., for Antidepressants, Level I, II 2 x 5 x 1 ml Malondialdehyde ■ Analytes: See title Antiepileptics Order no. Description Quantity ■ Analytes:

32080 ClinChek® Plasma Control, lyophil., for Malondialdehyde, Level I 10 x 0.5 ml Bromide, carbamazepine, carbamazepine-epoxide, N-desmethylmethsuximide,

32081 ClinChek® Plasma Control, lyophil., for Malondialdehyde, Level II 10 x 0.5 ml ethosuximide, 10-hydroxy-carbamazepine, oxcarbazepine, phenobarbital,

32082 ClinChek® Plasma Control, lyophil., for Malondialdehyde, Level I, II 2 x 5 x 0.5 ml phenylethylmalonamide, phenytoin, primidone, valproic acid Order no. Description Quantity

15080 ClinChek® Serum Control, lyophil., Antiepileptics, Level I 10 x 3 ml Mycophenolic Acid 15081 ClinChek® Serum Control, lyophil., Antiepileptics, Level II 10 x 3 ml ■ Analytes: 15082 ClinChek® Serum Control, lyophil., Antiepileptics, Level I, II 2 x 5 x 3 ml See title Order no. Description Quantity ■ Analytes:

29080 ClinChek® Plasma Control, lyophil., for Mycophenolic Acid, Level I 10 x 3 ml Felbamate, gabapentine, 10-hydroxy-carbamazepine, lacosamide, lamotrigine,

29081 ClinChek® Plasma Control, lyophil., for Mycophenolic Acid, Level II 10 x 3 ml levetiracetam, oxcarbazepine, perampanel, pregabaline, retigabine, rufinamide,

29082 ClinChek® Plasma Control, lyophil., for Mycophenolic Acid, Level III 10 x 3 ml stiripentol, sulthiame, tiagabine, topiramate, vigabatrine, zonisamide

29083 ClinChek® Plasma Control, lyophil., for Mycophenolic Acid, Level I, II, III 3 x 3 x 3 ml Order no. Description Quantity 15282 ClinChek® Serum Control, lyophil., Antiepileptics 2, Level I, II 2 x 5 x 2 ml ®

234 235 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 236

Product Survey Benzodiazepines ■ Analytes: Alprazolam, 7-aminoclonazepam, 7-aminoflunitrazepam, 7-aminonitrazepam, bromazepam, Antiepileptics chlordiazepoxide, clobazam, clonazepam, demoxepam, desalkylflurazepam, desmethylflunitrazepam, ■ Analytes: diazepam, estazolam, flunitrazepam, flurazepam, α-hydroxyalprazolam, 3-hydroxy-bromazepam, Carbamazepine, carbamazepine-epoxide, ethosuximide, 10-hydroxy-carbamazepine, α-hydroxymidazolam, α-hydroxytriazolam, lorazepam, lormetazepam, medazepam, midazolam, lamotrigine, oxcarbazepine, phenobarbital, phenytoin, primidone, sulthiame nitrazepam, norclobazam, nordiazepam, oxazepam, prazepam, temazepam, tetrazepam, trazodone, Order no. Description Quantity triazolam, zaleplon, zolpidem, zopiclone, zopiclone + ACP

14080 ClinChek® Serum Control, lyophil., Antiepileptics 3, Level I 10 x 3 ml Order no. Description Quantity

14081 ClinChek® Serum Control, lyophil., Antiepileptics 3, Level II 10 x 3 ml MS6082 ClinChek® Serum Control, lyophil., for Benzodiazepines, Level I, II 2 x 5 x 1 ml

14082 ClinChek® Serum Control, lyophil., Antiepileptics 3, Level I, II 2 x 5 x 3 ml

■ Analytes: CDT N-Desmethylmethsuximide, felbamate, lacosamide, rufinamide, zonisamide ■ Analytes: Order no. Description Quantity A-, di-, mono-, tri-, tetra-, penta-, hexasialotransferrin

14180 ClinChek® Serum Control, lyophil., Antiepileptics 4, Level I 10 x 3 ml Order no. Description Quantity

14181 ClinChek® Serum Control, lyophil., Antiepileptics 4, Level II 10 x 3 ml 21080 ClinChek® Serum Control, lyophil., for CDT, Level I 10 x 1 ml

14182 ClinChek® Serum Control, lyophil., Antiepileptics 4, Level I, II 2 x 5 x 3 ml 21081 ClinChek® Serum Control, lyophil., for CDT, Level II 10 x 1 ml 21082 ClinChek® Serum Control, lyophil., for CDT, Level I, II 2 x 5 x 1 ml

■ Analytes: Carbamazepine, carbamazepine-diol, carbamazepine-epoxide, N-desmethylmethsuximide, ethosuximide, felbamate, gabapentine, 10-hydroxy-carbamazepine, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, Drugfree perampanel, phenobarbital, phenylethylmalonamide, phenytoin, pregabaline, primidone, retigabine, ■ Analytes: rufinamide, stiripentol, sulthiame, theophylline, tiagabine, topiramate, valproic acid, vigabatrine, zonisamide Blank matrix Order no. Description Quantity Order no. Description Quantity

MS9282 ClinChek® Serum Control, lyophil., Antiepileptics 5, Level I, II 2 x 5 x 1 ml 8850 ClinChek® Serum Control, lyophil., Drugfree (animal origin) 10 x 10 ml 8851 ClinChek® Serum Control, lyophil., Drugfree (human origin) 10 x 5 ml

■ Analytes: 8850B ClinChek® Serum Control, frozen, Drugfree (animal origin) 500 ml

Levetiracetam (Keppra®) 8851B ClinChek® Serum Control, frozen, Drugfree (human origin) 500 ml Order no. Description Quantity

15580 ClinChek® Serum Control, lyophil., for Levetiracetam (Keppra®), Level I 10 x 3 ml

15581 ClinChek® Serum Control, lyophil., for Levetiracetam (Keppra®), Level II 10 x 3 ml Ethylglucuronide

15582 ClinChek® Serum Control, lyophil., for Levetiracetam (Keppra®), Level I, II 2 x 5 x 3 ml ■ Analytes: Ethylglucuronide, ethylsulfate Order no. Description Quantity Antiretrovirals MS8180 ClinChek® Serum Control, lyophil., for Ethylglucuronide, Level I 10 x 1 ml ■ Analytes: MS8181 ClinChek® Serum Control, lyophil., for Ethylglucuronide, Level II 10 x 1 ml Amprenavir, atazanavir, darunavir, efavirenz, etravirine, indinavir, lopinavir, maraviroc, nelfinavir, MS8182 ClinChek® Serum Control, lyophil., for Ethylglucuronide, Level I, II 2 x 5 x 1 ml nevirapine, raltegravir, rilpivirine, ritonavir, saquinavir, tipranavir Order no. Description Quantity

MS4082 ClinChek® Serum Control, lyophil., for Antiretrovirals, Level I, II 2 x 5 x 0.5 ml Metanephrines ■ Analytes: Metanephrine, 3-methoxytyramine, normetanephrine Order no. Description Quantity

MS11080 ClinChek® Serum Control, lyophil., for Metanephrines, Level I 10 x 3 ml

MS11081 ClinChek® Serum Control, lyophil., for Metanephrines, Level II 10 x 3 ml

MS11082 ClinChek® Serum Control, lyophil., for Metanephrines, Level III 10 x 3 ml

MS11083 ClinChek® Serum Control, lyophil., for Metanephrines, Level I, II, III 3 x 3 x 3 ml ®

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Product Survey Steroids ■ Analytes: Androstenedione, cortisol, dehydroepiandrosterone (DHEAS), 11-deoxycortisol, 21-deoxycortisol, Methylmalonic Acid 17-hydroxy-progesterone, 21-hydroxy-progesterone, testosterone ■ Analytes: Order no. Description Quantity

See title MS12083 ClinChek® Serum Control, lyophil., for Steroids, Level I, II, III 3 x 3 x 2 ml Order no. Description Quantity

MS5080 ClinChek® Serum Control, lyophil., for Methylmalonic Acid, Level I 10 x 2 ml MS5081 ClinChek® Serum Control, lyophil., for Methylmalonic Acid, Level II 10 x 2 ml Trace Elements MS5082 ClinChek® Serum Control, lyophil., for Methylmalonic Acid, Level I, II 2 x 5 x 2 ml ■ Analytes: Ag, Al, As, Au, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Fluoride, Hg, Iodid, Li, Mg, Mn, Mo, Ni, Pd, Pt, Sb, Se, Sn, Ti, Tl, V, Zn Psychoactive Drugs TDM 1 - TDM 4, TDM6 Order no. Description Quantity ■ Analytes: 8880 ClinChek® Serum Control, lyophil., for Trace Elements, Level I 10 x 3 ml

Aripiprazole, citalopram, dehydro-aripiprazole, desmethylcitalopram, O-desmethylvenlafaxine, 8881 ClinChek® Serum Control, lyophil., for Trace Elements, Level II 10 x 3 ml

10-hydroxy-carbamazepine, lamotrigine, norquetiapine, perazine, quetiapine, venlafaxine 8882 ClinChek® Serum Control, lyophil., for Trace Elements, Level I, II 2 x 5 x 3 ml Order no. Description Quantity

8702 ClinChek® Serum Control, lyophil., for Psychoactive Drugs TDM1, Level I, II 2 x 5 x 5 ml Tricyclic Antidepressants ■ Analytes: ■ Analytes: Amisulpride, desmethylmirtazapine, O-desmethylvenlafaxine, escitalopram, mirtazapine, Amitriptyline, clomipramine, clozapine, desipramine, desmethylclozapine, doxepin, quetiapine, venlafaxine imipramine, maprotiline, norclomipramine, nordoxepin, nortrimipramine, nortriptyline, Order no. Description Quantity protriptyline, trimipramine 8705 ClinChek® Serum Control, lyophil., for Psychoactive Drugs TDM2, Level I, II 2 x 5 x 5 ml Order no. Description Quantity

MS9182 ClinChek® Serum Control, lyophil., for Tricyclic Antidepressants, Level I, II 2 x 5 x 1 ml ■ Analytes: Clozapine, desmethylclozapine, desmethylolanzapine, duloxetine, haloperidol, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone Vitamin C Order no. Description Quantity ■ Analytes: 8708 ClinChek® Serum Control, lyophil., for Psychoactive Drugs TDM3, Level I, II 2 x 5 x 5 ml See title Order no. Description Quantity

■ Analytes: 28080 ClinChek® Serum Control, lyophil., for Vitamin C, Level I 10 x 0.5 ml

Amitriptyline, clomipramine, clozapine, desipramine, desmethylclozapine, doxepin, imipramine, 28081 ClinChek® Serum Control, lyophil., for Vitamin C, Level II 10 x 0.5 ml

maprotiline, norclomipramine, nordoxepin, nortriptyline, trimipramine 28082 ClinChek® Serum Control, lyophil., for Vitamin C, Level I, II 2 x 5 x 0.5 ml Order no. Description Quantity

8711 ClinChek® Serum Control, lyophil., for Psychoactive Drugs TDM4, Level I, II 2 x 5 x 5 ml 25-OH Vitamin D2 / D3 ■ Analytes: ■ Analytes: Aripiprazole, bupropion, citalopram, dehydro-aripiprazole, desmethylfluoxetine, desmethylmirtazapine, 25-hydroxy-vitamin D2, 25-hydroxy-vitamin D3 desmethylsertraline, O-desmethylvenlafaxine, duloxetine, erythro-dihydro-bupropion, fluoxetine, Order no. Description Quantity

fluvoxamine, hydroxybupropion, mianserin, mirtazapine, paroxetine, sertindole, sertraline, 35080 ClinChek® Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level I 10 x 2 ml

threo-dihydro-bupropion, venlafaxine 35081 ClinChek® Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level II 10 x 2 ml

Order no. Description Quantity 35082 ClinChek® Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level I, II 2 x 5 x 2 ml

8717 ClinChek® Serum Control, lyophil., for Psychoactive Drugs TDM6, Level I, II 2 x 5 x 5 ml MS7080 ClinChek® Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level I 10 x 1 ml

MS7081 ClinChek® Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level II 10 x 1 ml

MS7082 ClinChek® Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level I, II 2 x 5 x 1 ml ®

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Product Survey Hemoglobins F / A2 / S ■ Analytes: Hemoglobin F, hemoglobin A2 Vitamins Order no. Description Quantity ■ Analytes: 13182 ClinChek® Hemolysate Control, ready to use, for Hemoglobins F / A2, Level I, II 2 x 5 x 3 ml All-trans-retinol (vitamin A), alpha-tocopherol (vitamin E), pyridoxal (vitamin B6), pyridoxal-5-phosphate (vitamin B6) ■ Analytes: Order no. Description Quantity Hemoglobin F, hemoglobin A2, hemoglobin S

8870 ClinChek® Serum Control, lyophil., for Vitamins, Level I 10 x 5 ml Order no. Description Quantity

8871 ClinChek® Serum Control, lyophil., for Vitamins, Level II 10 x 5 ml 13183 ClinChek® Hemolysate Control, ready to use, for Hemoglobins F / A2 / S, Level I 5 x 3 ml

8872 ClinChek® Serum Control, lyophil., for Vitamins, Level III 10 x 5 ml

8873 ClinChek® Serum Control, lyophil., for Vitamins, Level I, II, III 3 x 3 x 5 ml Homocysteine ■ Analytes: ClinChek® Whole Blood Controls, Lyophilised / Ready for Use: See title Order no. Description Quantity Amino Acids and Acylcarnitines MS2182 ClinChek® Dried Blood Spot Control (DBS), for Homocysteine, Level I, II 2 x 1 x 3 spots Analytes: Acetylcarnitine, alanine, arginine, aspartic acid, butyrylcarnitine, carnitine, citrulline, decanoylcarnitine, dodecanoylcarnitine, glutamic acid, glutarylcarnitine, glycine, Immunosuppressants hexadecanoylcarnitine, hexanoylcarnitine, isovalerylcarnitine, leucine, methionine, ■ Analytes: octadecanoylcarnitine, octanoylcarnitine, ornithine, phenylalanine, proline, Cyclosporine A, everolimus, sirolimus, tacrolimus propionylcarnitine, tetradecanoylcarnitine, tyrosine, valine Order no. Description Quantity Order no. Description Quantity 8830 ClinChek® Whole Blood Control, lyophil., for Immunosuppressants, Level I 5 x 2 ml

MS10182 ClinChek® Dried Blood Spot Control (DBS) for 2 x 1 x 3 spots 8831 ClinChek® Whole Blood Control, lyophil., for Immunosuppressants, Level II 5 x 2 ml Amino Acids and Acylcarnitines, Level I,II 8832 ClinChek® Whole Blood Control, lyophil., for Immunosuppressants, Level III 5 x 2 ml 8833 ClinChek® Whole Blood Control, lyophil., for Immunosuppressants, Level I, II, III 3 x 2 x 2 ml

8903 ClinChek® Whole Blood Control, lyophil., for Immunosuppressants, Level IV, V 2 x 2 x 2 ml Hemoglobin A1c ■ Analytes: HbA1c, HbF Trace Elements Order no. Description Quantity ■ Analytes:

11080 ClinChek® Hemolysate Control, ready to use, for Hemoglobin A1c, Level I 10 x 5 ml Ag, As, Ca, Cd, Co, Cr, Cu, Fe, Hg, K, Mg, Mn, Mo, Na, Ni, Pb, Pt, Sb, Se, Sn, Tl, Zn

11081 ClinChek® Hemolysate Control, ready to use, for Hemoglobin A1c, Level II 10 x 5 ml Order no. Description Quantity

11082 ClinChek® Hemolysate Control, ready to use, for Hemoglobin A1c, Level I, II 2 x 5 x 5 ml 8840 ClinChek® Whole Blood Control, lyophil., for Trace Elements, Level I 10 x 5 ml 8841 ClinChek® Whole Blood Control, lyophil., for Trace Elements, Level II 10 x 5 ml

8842 ClinChek® Whole Blood Control, lyophil., for Trace Elements, Level III 10 x 5 ml Hemoglobin, free 8843 ClinChek® Whole Blood Control, lyophil., for Trace Elements, Level I, II, III 3 x 3 x 5 ml ■ Analytes: See title Order no. Description Quantity Vitamins B1, B2, B6

8812 ClinChek® Hemoglobin Control, lyophil., for free Hemoglobin, Level I 9 x 1 ml ■ Analytes:

8813 ClinChek® Hemoglobin Control, lyophil., for free Hemoglobin, Level II 9 x 1 ml Flavin adenine dinucleotide (FAD), pyridoxal, pyridoxal-5-phosphate (PLP),

8814 ClinChek® Hemoglobin Control, lyophil., for free Hemoglobin, Level III 9 x 1 ml thiaminepyrophosphate (TPP)

8816 ClinChek® Hemoglobin Control, lyophil., for free Hemoglobin, Level I, II, III 3 x 3 x 1 ml Order no. Description Quantity

8912 ClinChek® Hemoglobin Control (low), lyophil., for free Hemoglobin, Level I 9 x 1 ml 8874 ClinChek® Whole Blood Control, lyophil., for Vitamins B1, B2, B6, Level I 10 x 2 ml

8913 ClinChek® Hemoglobin Control (low), lyophil., for free Hemoglobin, Level II 9 x 1 ml 8875 ClinChek® Whole Blood Control, lyophil., for Vitamins B1, B2, B6, Level II 10 x 2 ml

8914 ClinChek® Hemoglobin Control (low), lyophil., for free Hemoglobin, Level III 9 x 1 ml 8876 ClinChek® Whole Blood Control, lyophil., for Vitamins B1, B2, B6, Level I, II 2 x 5 x 2 ml

8916 ClinChek® Hemoglobin Control (low), lyophil., for free Hemoglobin, Level I, II, III 3 x 3 x 1 ml ®

240 241 ClinChek Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 242

Index

Acetylcarnitine (C2-Carnitine) ...... 154 - 157, 240 Biogenic Amines ...... 18 - 37 Carbamazepine-d10 ...... 168 11-Deoxycorticosterone

2 2 Acetylcarnitine- H3 ( H3-C2) ...... 168 Bismuth ...... 204, 208, 235, 239 Carbamazepine-diol . . . . . 138 - 139, 148 - 149, 164, 205, 236 (21-Hydroxy-Progesterone) ...... 207, 239 Acylcarnitines ...... 154 - 157, 240 Bisphenol A ...... 201, 231 Carbamazepine-epoxide ...... 138 - 139, 148 - 149, 164, 11-Deoxycortisol ...... 207, 239 Alanine ...... 154 - 157, 202, 232, 240 Blank (Drugfree) ...... 237 ...... 205, 235, 236 21-Deoxycortisol ...... 207, 239

13 15 Alanine- C3 N ...... 168 Br2-CA [3-(2,2-Dibromovinyl)- Carbohydrate deficient transferrin (CDT) ...... 12 - 17, 237 Desalkylflurazepam ...... 134 - 135, 144 - 145, 165, 206, 237 Alprazolam ...... 134 - 135, 144 - 145, 165, 206, 237 2,2-dimethylcyclopropan- Carnitine (C0-Carnitine) ...... 154 - 157, 204 Desethylamiodarone ...... 76 - 77, 176, 204, 235

2 2 Alprazolam-d5 ...... 169 1-carboxylic acid]) ...... 231 Carnitine- H9 ( H9-C0 ) ...... 168 Desipramine ...... 136 - 137, 146 - 147, 167, Aluminium ...... 201, 204, 208, 232, 235, 239 Bromazepam ...... 134 - 135, 144 - 145, 165, 206, 237 β-Carotene, all-trans ...... 52 - 53, 177, 203, 233 ...... 207, 208, 238, 239

Amino Acids ...... 154 -157, 240 Bromide ...... 205, 235 CDT (Carbohydrate deficient transferrin) . . . . 12 - 17, 177, 237 Desipramine-d3 ...... 171 α-Aminobutyric acid ...... 202, 232 Bupropion ...... 140 - 141, 150 - 151, 164, Chlordiazepoxide ...... 134 - 135, 144 - 145, 165, 206, 237 Desmethylcitalopram ...... 207, 238

7-Aminoclonazepam . . . . . 134 - 135, 144 - 145, 165, 206, 237 ...... 204, 207, 235, 238 Chlordiazepoxide-d5 ...... 169 Desmethylclozapine (Norclozapine) ...... 92 - 93, 177, 202,

7-Aminoclonazepam-d4 ...... 169 Bupropion, erythro-Dihydro- ...... 140 - 141, 150 - 151, 164, Chromium ...... 201, 204, 208, 209, ...... 207, 233, 238 7-Aminoflunitrazepam . . . . 134 - 135, 144 - 145, 165, 206, 237 ...... 204, 207, 235, 238 ...... 232, 235, 239, 241 Desmethylflunitrazepam

7-Aminoflunitrazepam-d7 ...... 169 Bupropion, Hydroxy- . . . . . 140 - 141, 150 - 151, 164, 204, 235 cis-Cl2-CA [cis-3-(2,2-Dichlorovinyl)- (Norflunitrazepam) ...... 134 - 135, 144 - 145, 165, 206, 237 5-ALA (5-Aminolevulinic acid) ...... 108 - 109, 200, 201, Bupropion, threo-Dihydro- ...... 140 - 141, 150 - 151, 164, 2,2-dimethylcyclopropan-1-carboxylic acid] ...... 231 Desmethylfluoxetine ...... 207, 238

...... 230, 232 ...... 204, 207, 235, 238 Citalopram ...... 140 - 141, 150 - 151, 164, Desmethylfluoxetine-d5 ...... 168

5-Aminolevulinic acid (5-ALA) ...... 108 - 109, 200, 201, Bupropion-d9 ...... 168 ...... 204, 207, 235, 238 N-Desmethylmethsuximide (NDMS) ...... 82 - 85, 138 - 139,

...... 230, 232 Butoxy acetic acid ...... 201, 231 Citalopram-d6 ...... 168 ...... 148 - 149, 164, 176, 205, 235, 236 7-Aminonitrazepam ...... 134 - 135, 144 - 145, 165, 206, 237 Butyrylcarnitine (C4-Carnitin) ...... 154 - 157, 240 Citrulline ...... 154 - 157, 202, 204, 232 Desmethylmirtazapine ...... 207, 238

2 2 2 Amiodarone ...... 76 - 77, 176, 204, 235 Butyrylcarnitine- H3 ( H3-C4) ...... 168 Citrulline- H7 ...... 168 Desmethylolanzapin (Norolanzapin) ...... 207, 238

2 2 Amisulpride ...... 207, 238 H9-C0 (Carnitine- H9) ...... 168 Clobazam ...... 134 - 135, 144 - 145, 165, 206, 237 Desmethylolanzapine ...... 92 - 93, 177, 202, 207, 233, 238 Amitriptyline ...... 136 - 137, 146 - 147, 167, C0-Carnitine (Carnitine) ...... 154 - 157, 240 Clomethiazole ...... 140 - 141, 150 - 151, 164, 204, 235 Desmethylsertraline ...... 207, 238

...... 207, 208, 238, 239 C2-Carnitine (Acetylcarnitine) ...... 154 - 157, 240 Clomipramine ...... 136 - 137, 146 - 147, 167, Desmethylsertraline-d4 ...... 168

Amitriptyline-d3 ...... 171 C3-Carnitine (Propionylcarnitine) ...... 154 - 157, 240 ...... 207, 208, 238, 239 O-Desmethylvenlafaxine ...... 207, 238

Amprenavir ...... 164, 205, 236 C4-Carnitine (Butyrylcarnitine) ...... 154 - 157, 240 Clomipramine-d3 ...... 171 DHEAS (Dehydroepiandrosterone) ...... 207, 239

Amprenavir-d4 ...... 169 C5-Carnitine (Isovalerylcarnitine) ...... 154 - 157, 240 Clonazepam ...... 134 - 135, 144 - 145, 165, 206, 237 Diazepam ...... 134 - 135, 144 - 145, 165, 206, 237

Androstenedione ...... 207, 239 C5DC-Carnitine (Glutarylcarnitine) ...... 154 - 157, 240 Clonazepam-d4 ...... 169 Diazepam-d5 ...... 169 Antiarrhytmics ...... 76 -77 C6-Carnitine (Hexanoylcarnitine) ...... 154 - 157, 240 Clozapine ...... 92 - 93, 136 - 137, 146 - 147, 167, Dimethylarsinic acid ...... 230 Antidepressants ...... 140 - 141, 150 - 151 C8-Carnitine (Octanoylcarnitine) ...... 154 - 157, 240 ...... 177, 202, 207, 208, 233, 238, 239 Diphenylhydantoin (Phenytoin) ...... 138 - 139, 148 - 149,

2 2 Antiepileptics ...... 80 - 89, 138 - 139, 148 - 149 H3-C10 (Decanoylcarnitine- H3) ...... 168 Clozapine-d4 ...... 171 ...... 164, 205, 235, 236 Antimony ...... 201, 204, 208, 232, 235, 239, 241 C10-Carnitine (Decanoylcarnitine) ...... 154 - 157, 240 Cobalt ...... 201, 204, 208, 209, Disialotransferrin ...... 12 - 17, 237

2 2 Antiretrovirals ...... 164, 169, 205, 236 H3-C12 (Odecanoylcarnitine- H3) ...... 168 ...... 232, 235, 239, 241 Dodecanoylcarnitine (C12-Carnitine) ...... 154 - 157, 204 Arginine ...... 154-157, 202, 232, 240 C12-Carnitine (Dodecanoylcarnitine) ...... 154 - 157, 240 Coenzyme Q10 (Ubiquinone) ...... 54 - 55, 177, 203, 234 Dopamine ...... 18 - 25, 177, 200, 203, 230, 233

13 2 2 Arginine- C6 ...... 168 H3-C14 (Tetradecanoylcarnitine- H3) ...... 168 Copper ...... 201, 204, 208, 209, Dosulepin ...... 140 - 141, 150 - 151, 164, 204, 235

Aripiprazole ...... 207, 238 C14-Carnitine (Tetradecanoylcarnitine) ...... 154 - 157, 240 ...... 232, 235, 239, 241 Dosulepin-d3 ...... 168

2 2 Aripiprazole, Dehydro- ...... 207, 238 H3-C16 (Hexadecanoylcarnitine- H3) ...... 168 Coproporphyrin I ...... 50 - 51, 180, 201, 232 Doxepin ...... 136 - 137, 146 - 147, 167, Arsenic ...... 201, 204, 208, 209, 230, C16-Carnitine (Hexadecanoylcarnitine) ...... 154 - 157, 240 Coproporphyrin III ...... 50 - 51, 180, 201, 232 ...... 207, 208, 238, 239

2 2 ...... 232, 235, 239, 241 H3-C18 (Octadecanoylcarnitine- H3) ...... 168 Cortisol ...... 207, 239 Doxepin-d3 ...... 171 Arsenic V ...... 230 C18-Carnitine (Octadecanoylcarnitine) ...... 154 - 157, 240 Cotinine ...... 201, 231 Drugfree ...... 237

2 2 Arsenobetaine ...... 230 H3-C2 (Acetylcarnitine- H3) ...... 168 Cotinine-d3 ...... 171 Duloxetine ...... 140 - 141, 150 - 151, 164,

2 2 Ascorbic Acid (Vitamin C) ...... 58 - 59, 208, 239 H3-C3 (Propionylcarnitine- H3) ...... 168 o-Cresol ...... 96 - 97, 201, 231 ...... 204, 207, 235, 238

2 2 Asialotransferrin ...... 12 - 17, 237 H3-C4 (Butyrylcarnitine- H3) ...... 168 Cyclosporine A ...... 130 - 131, 166, 209, 241 Duloxetine-d7 ...... 168

2 2 Asparagine ...... 202, 232 H9-C5 (Isovalerylcarnitine- H9) ...... 168 Cyclosporine A-d12 ...... 170 Efavirenz ...... 164, 205, 236

2 2 Aspartic acid ...... 154 - 157, 202, 232, 240 H9-C5DC (Glutarylcarnitine- H9) ...... 168 Cyclosporine D ...... 170 Efavirenz-d4 ...... 169

13 2 2 Aspartic acid- C4 ...... 168 H3-C6 (Hexanoylcarnitine- H3) ...... 168 Darunavir ...... 164, 205, 236 Epinephrine ...... 18 - 25, 177, 200, 203, 230, 233

2 2 Atazanavir ...... 164, 205, 236 H3-C8 (Octanoylcarnitine- H3) ...... 168 Darunavir-d9 ...... 169 erythro-Dihydro-Bupropion ...... 204, 207, 235, 238

Atazanavir-d5 ...... 169 Cadmium ...... 201, 204, 208, 209, Decanoylcarnitine (C10-Carnitine) ...... 154 - 157, 204 Escitalopram ...... 207, 238

2 2 Atomoxetine ...... 140 - 141, 150 - 151, 164, 204, 235 ...... 232, 235, 239, 241 Decanoylcarnitine- H3 ( H3-C10) ...... 168 Estazolam ...... 134 - 135, 144 - 145, 165, 206, 237

Atomoxetine-d3 ...... 168 Caffeine ...... 78 - 79, 176, 202, 232 Dehydro-Aripiprazole ...... 207, 238 Estazolam-d5 ...... 169 Barium ...... 201, 208, 232, 239 Calcium ...... 241 Dehydroepiandrosterone (DHEAS) ...... 207, 239 Ethosuximide ...... 82 - 85, 138 - 139, 148 - 149, 164, Benzodiazepines ...... 134 - 135, 144 - 145 Carbamazepine ...... 80 - 85, 138 - 139, 148 - 149, Demoxepam ...... 134 - 135, 144 - 145, ...... 176, 205, 235, 236

Beryllium ...... 201, 204, 208, 232, 235, 239 ...... 164, 176, 205, 235, 236 ...... 165, 206, 237 Ethosuximide-d3 ...... 168 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:16 Seite 244

Index

Ethoxy acetic acid ...... 201, 231 Hemoglobin, free ...... 178, 240 Isovalerylcarnitine (C5-Carnitine) ...... 154 - 157, 204 3-Methoxytyramine-d4 ...... 170

2 2 Ethylglucuronide ...... 118 - 119, 165, 200, 231 Heptacarboxyporphyrin I ...... 50 - 51, 180, 201, 232 Isovalerylcarnitine- H9 ( H9-C5) ...... 168 Methylenedianiline ...... 201, 231

Ethylglucuronide-d5 ...... 169 Hexacarboxyporphyrin Iab + lac ...... 50 - 51, 180, 201, 232 Itraconazole ...... 202, 233 N-Methylformamide ...... 201, 231 Ethylsulfate ...... 118 - 119, 165, 200, 231 Hexadecanoylcarnitine (C16-Carnitine) ...... 154 - 157, 240 Keppra® (Levetiracetam) ...... 138 - 139, 148 - 149, m/p-Methyl-hippuric acid ...... 201, 231

2 2 Ethylsulfate-d5 ...... 169 Hexadecanoylcarnitine- H3 ( H3-C16) ...... 168 ...... 164, 205, 235, 236 o-Methyl-hippuric acid ...... 201, 231 Etravirine ...... 164, 205, 236 Hexanoylcarnitine (C6-Carnitine) ...... 154 - 157, 240 Lacosamide ...... 82 - 85, 138 - 139, 148 - 149, 1-Methyl-histidine ...... 202, 232

2 2 Etravirine-d8 ...... 169 Hexanoylcarnitine- H3 ( H3-C6 ) ...... 168 ...... 164, 176, 205, 235, 236 3-Methyl-histidine ...... 202, 232

Everolimus ...... 130 - 131, 166, 209, 241 Hexasialotransferrin ...... 12 - 17, 237 Lacosamide-d3 ...... 168 Methylmalonic Acid ...... 124 - 125, 206, 238

13 Everolimus- C2d4 ...... 170 5-HIAA (5-Hydroxyindoleacetic acid) ...... 34 - 37, 177, 200, Lamotrigine ...... 82 - 87, 138 - 139, 148 - 149, 164, Methylmalonic acid-d3 ...... 171

Everolismus-d4 ...... 170 ...... 203, 230, 233 ...... 176, 205, 207, 235, 236, 238 Mianserin ...... 140 - 141, 150 - 151, 164,

13 FAD (Flavin adenine dinucleotide, Hippuric acid ...... 201, 231 Lamotrigine- C3 ...... 168 ...... 204, 207, 235, 238

Vitamin B2) ...... 64 - 65, 68 - 69, 180, 209, 241 Histidine ...... 202, 232 Lead ...... 201, 209, 232, 241 Mianserin-d3 ...... 168 Felbamate ...... 82 - 85, 138 - 139, 148 - 149, Homocysteine ...... 46 - 47, 122 - 123, 178, Leucine ...... 154 - 157, 202, 232, 240 MiBP (Mono-iso-butylphthalate) ...... 231

2 ...... 164, 176, 205, 235, 236 ...... 203, 206, 209, 234, 241 Leucine- H3 ...... 168 Midazolam ...... 134 - 135, 144 - 145, 165, 206, 237

® Felbamate-d4 ...... 168 Homocysteine-d8 ...... 169 Levetiracetam (Keppra ) ...... 82 - 85, 138 - 139, 148 - 149, Midazolam-d4 ...... 169 Flavin adenine dinucleotide Homovanillic acid (HVA) . . . . . 34 - 37, 177, 200, 203, 230, 233 ...... 164, 176, 205, 235, 236 Milnacipran ...... 140 - 141, 150 - 151, 164, 204, 235

(FAD, Vitamin B2) ...... 64 - 65, 68 - 69, 180, 209, 241 HVA (Homovanillic acid) . . . . . 34 - 37, 177, 200, 203, 230, 233 Levetiracetam-d6 ...... 168 Milnacipran-d10 ...... 168 Fluconazole ...... 202, 233 α-Hydroxyalprazolam . . . . 134 - 135, 144 - 145, 165, 206, 237 Lithium ...... 204, 235 Mirtazapine ...... 140 - 141, 150 - 151, 164,

Flunitrazepam ...... 134 - 135, 144 - 145, 165, 206, 237 α-Hydroxyalprazolam-d5 ...... 169 Lopinavir ...... 164, 205, 236 ...... 204, 207, 235, 238

Flunitrazepam-d7 ...... 169 3-Hydroxybromazepam . . . 134 - 135, 144 - 145, 165, 206, 237 Lopinavir-d8 ...... 169 Mirtazapine, Desmethyl- ...... 140 - 141, 150 - 151, 164, Fluoride ...... 201, 204, 208, 232, 235, 239 Hydroxybupropion ...... 207, 238 Lorazepam ...... 134 - 135, 144 - 145, 165, 206, 237 ...... 204, 235

Fluoxetine ...... 140 - 141, 150 - 151, 164, 10-Hydroxy-Carbamazepine . . . . 82 - 85, 138 - 139, 148 - 149, Lorazepam-d4 ...... 169 Mirtazapine-d3 ...... 168 ...... 204, 207, 235, 238 ...... 164, 176, 205, 207, 235, 236, 238 Lormetazepam ...... 134 - 135, 144 - 145, 165, 206, 237 MnBP (Mono-n-butylphthalate) ...... 231 Fluoxetine, Desmethyl- . . . 140 - 141, 150 - 151, 164, 204, 235 3-Hydroxycotinine ...... 201, 231 Lysine ...... 202, 232 Moclobemide ...... 140 - 141, 150 - 151, 164, 204, 235

Fluoxetine-d5 ...... 168 Hydroxycotinine-d3 ...... 171 Magnesium ...... 201, 204, 208, 209, Moclobemide-d8 ...... 168 Flurazepam ...... 134 - 135, 144 - 145, 165, 206, 237 5-Hydroxyindoleacetic acid ...... 232, 235, 239, 241 Molybdenum ...... 201, 204, 208, 209, 232, 235, 239, 241 Fluvoxamine ...... 140 - 141, 150 - 151, 164, (5-HIAA) ...... 34 - 37, 177, 200, 203, 230, 233 Malondialdehyde ...... 56 - 57, 203, 234 Monomethylarsonic Acid ...... 230 ...... 204, 207, 235, 238 Hydroxy-Itraconazole ...... 202, 233 Mandelic acid ...... 201, 231 Monosialotransferrin ...... 12 - 17, 237

Fluvoxamine-d3 ...... 168 α-Hydroxymidazolam . . . . 134 - 135, 144 - 145, 165, 206, 237 Manganese ...... 201, 204, 208, 209, t,t-Muconic Acid ...... 201, 231

Free hemoglobin ...... 240 α-Hydroxymidazolam-d4 ...... 169 ...... 232, 235, 239, 241 Mycophenolic Acid ...... 90 - 91, 179, 204, 234

Gabapentine ...... 138 - 139, 148 - 149, 4-Hydroxyproline ...... 34 - 37, 177, 200, 202, Maproteline-d5 ...... 171 1-Naphthol ...... 96 - 97, 201, 231 ...... 164, 205, 235, 236 ...... 203, 230, 232, 233 Maprotiline ...... 136 - 137, 146 - 147, 167, 2-Naphthol ...... 96 - 97, 201, 231 Glutamic acid ...... 154 - 157, 202, 204, 232 1-Hydroxypyrene ...... 96 - 97, 201, 231 ...... 207, 208, 238, 239 NDMS (N-Desmethylmethsuximide) ...... 82 - 85, 138 - 139,

13 Glutamic acid- C5 ...... 168 9-Hydroxy-Risperidone (Paliperidone) ...... 92 - 93, 177, Maraviroc ...... 164, 205, 236 ...... 148 - 149, 164, 176, 205, 235, 236

Glutamine ...... 202, 232 ...... 203, 207, 233, 238 Maraviroc-d6 ...... 169 Nelfinavir ...... 164, 205, 236

Glutarylcarnitine (C5DC-Carnitine) ...... 154 - 157, 240 α-Hydroxytriazolam ...... 134 - 135, 144 - 145, 165, 206, 237 MBzP (Mono-benzylphthalate) ...... 231 Nelfinavir-d3 ...... 169

2 2 Glutarylcarnitine- H9 ( H9-C5DC) ...... 168 α-Hydroxytriazolam-d4 ...... 169 Medazepam ...... 134 - 135, 144 - 145, 165, 206, 237 Nevirapine ...... 164, 205, 236

Glycine ...... 154 - 157, 202, 232, 240 25-Hydroxyvitamin D2 ...... 70 - 73, 126 - 127, 5-OH-MEHP [Mono-(2-ethyl- Nevirapine-d5 ...... 169 2-Glycine-13C15N ...... 168 ...... 167, 181, 208, 239 5-hydroxyhexyl) phthalate] ...... 231 Nickel ...... 201, 204, 208, 209, 232, 235, 239, 241 Gold ...... 201, 204, 207, 208, 25-Hydroxyvitamin D3 ...... 70 - 73, 126 - 127, 5-oxo-MEHP [Mono-(2-ethyl- Nicotine ...... 201, 231

...... 232, 235, 238, 239 ...... 167, 181, 208, 239 5-oxohexyl) phthalate] ...... 231 Nicotine-d3 ...... 171

Haloperidol ...... 207, 238 25-Hydroxy-Vitamin-D3-d6 ...... 171 5-cx-MEPP [Mono-(2-ethyl- Nitrazepam ...... 134 - 135, 144 - 145, 165, 206, 237

HbA0 (Hemoglobin A0) ...... 38 - 43, 178 25-Hydroxy-Vitamin-D3-d7 ...... 171 5-carboxypentyl) phthalate] ...... 231 Nitrazepam-d5 ...... 169 HbA1c (Hemoglobin A1c) ...... 38 - 43, 178, 209, 241 Imipramine ...... 136 - 137, 146 - 147, 167, 208, 239 Mercury ...... 201, 204, 208, 209, 232, 235, 239, 241 Norclobazam ...... 134 - 135, 144 - 145, 165, 206, 237

HbA2 (Hemoglobin A2) ...... 42 - 43, 178, 209, 241 Imipramine-d3 ...... 171 Metanephrine ...... 26 - 29, 120 - 121, 166, 179, Norclomipramine ...... 136 - 137, 146 - 147, 167, HbF (Hemoglobin F) ...... 38 - 43, 178, 209, 240, 241 Immunosuppressants ...... 90 - 91, 130 - 131 ...... 200, 206, 230, 237 ...... 207, 208, 238, 239

HbS (Hemoglobin S) ...... 178 Indinavir ...... 164, 205, 236 Methanephrine-d3 ...... 170 Norclomipramine-d3 ...... 171

Hemoglobin A0 (HbA0) ...... 38 - 43, 178 Indinavir-d6 ...... 169 Methionine ...... 154-157, 202, 232, 240 Norclozapine (Desmethylclozapine) ...... 92 - 93, 136 - 137,

2 Hemoglobin A1c (HbA1c) ...... 38 - 43, 178, 209, 241 Iodide ...... 201, 204, 208, 232, 235, 239 Methionine- H3 ...... 168 ...... 146 - 147, 167, 177, 202, Hemoglobin A2 (HbA2) ...... 42 - 43, 178, 209, 241 Iron ...... 201, 204, 208, 209, 232, 235, 239, 241 Methoxy acetic acid ...... 201, 231 ...... 207, 208, 233, 238, 239

Hemoglobin F (HbF) ...... 38 - 43, 178, 209, 240, 241 Isoleucine ...... 202, 232 3-Methoxytyramine ...... 26 - 29, 120 - 121, 166, 179, Norclozapine-d8 ...... 171 Hemoglobin S (HbS) ...... 178 allo-Isoleucine ...... 202, 232 ...... 200, 206, 230, 237 Nordiazepam ...... 134 - 135, 144 - 145, 165, 206, 237 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:17 Seite 246

Index

Nordiazepam-d5 ...... 169 Phenobarbital-d5 ...... 168 Saquinavir ...... 164, 205, 236 Topiramat ...... 138 - 139, 148 - 149,

Nordoxepin ...... 136 - 137, 146 - 147, 167, Phenol ...... 96 - 97, 201, 231 Saquinavir-d6 ...... 169 ...... 164, 205, 235, 236

...... 207, 208, 238, 239 3-Phenoxybenzoic acid (3-PBA) ...... 231 Selenium ...... 201, 204, 208, 209, Topiramat-d12 ...... 168

Nordoxepin-d3 ...... 171 Phenylalanine ...... 154 - 157, 202, 232, 240 ...... 232, 235, 239, 241 Total porphyrins ...... 50 - 51, 110 - 111, 180, 201, 232

13 Norepinephrine ...... 18 - 25, 177, 200, 203, 230, 233 Phenylalanine- C6 ...... 168 Serine ...... 202, 232 TPP (Thiaminepyrophosphate, Norflunitrazepam (Desmethylflunitrazepam) ...... 134 - 135, Phenylethylmalonamide (PEMA) ...... 80 - 81, 138 - 139, Serotonin ...... 30 - 33, 177, 200, 203, 230, 233 Vitamin B1) ...... 62 - 63, 68 - 69, 180, 209, 241

...... 144 - 145, 165, 206, 237 ...... 148 - 149, 164, 176, 205, 235, 236 Sertindole ...... 207, 238 trans-Cl2-CA [trans-3-(2,2-Dichlorovinyl)- Normetanephrine ...... 26 - 29, 120 - 121, 166, 179, Phenylglyoxylic acid ...... 201, 231 Sertraline ...... 140 - 141, 150 - 151, 164, 2,2-dimethylcyclopropan-1- ...... 200, 206, 230, 237 S-Phenylmercapturic acid ...... 201, 231 ...... 204, 207, 235, 238 carboxylic acid] ...... 231

Normetanephrine-d3 ...... 170 Phenytoin (Diphenylhydantoin) ...... 82 - 85, 138 - 139, Sertraline, N-Desmethyl- ...... 140 - 141, 150 - 151, Tranylcypromine ...... 140 - 141, 150 - 151, 164, 204, 235

Norolanzapine (Desmethylolanzapine) ...... 207, 238 ...... 148 - 149, 164, 176, 205, 235, 236 ...... 164, 204, 235 Tranylcypromine-d5 ...... 168

Norquetiapine ...... 207, 238 Phosphoserine ...... 202, 232 Sertraline-d3 ...... 168 Trazodone ...... 134 - 135, 140 - 141, 144 - 145, 150 - 151, Nortrimipramine ...... 136 - 137, 146 - 147, 167, 208, 239 Platinum ...... 201, 204, 208, 209, Silver ...... 204, 208, 209, 235, 239, 241 ...... 164, 165, 204, 206, 235, 237 Nortriptyline ...... 136 - 137, 146 - 147, 167, ...... 232, 235, 239, 241 Sirolimus ...... 130 - 131, 166, 209, 241 Triazolam ...... 134 - 135, 144 - 145, 165, 206, 237

13 ...... 207, 208, 238, 239 Porphobilinogen (PBG) . . . . . 50 - 51, 108 - 111, 180, 201, 232 Sirolimus- Cd3 ...... 170 Triazolam-d4 ...... 169

Nortriptyline-d3 ...... 171 Posaconazole ...... 202, 233 Sodium ...... 209, 241 Trichloroacetic acid ...... 201, 231 Octadecanoylcarnitine (C18-Carnitine) ...... 154 - 157, 240 Potassium ...... 209, 241 Steroids ...... 207, 239 Tricyclic Antidepressants ...... 136 - 137, 146 - 147

2 2 Octadecanoylcarnitine- H3 ( H3-C18) ...... 168 Prazepam ...... 134 - 135, 144 - 145, 165, 206, 237 Stiripentol ...... 138 - 139, 148 - 149, Trimipramine ...... 136 - 137, 146 - 147, 167,

Octanoylcarnitine (C8-Carnitine) ...... 154 - 157, 240 Prazepam-d5 ...... 169 ...... 164, 205, 235, 236 ...... 207, 208, 238, 239

2 2 Octanoylcarnitine- H3 ( H3-C8) ...... 168 Pregabaline ...... 138 - 139, 148 - 149, Stiripentol-d9 ...... 168 Trimipramine-d3 ...... 171

2 2 Odecanoylcarnitine- H3 ( H3-C12) ...... 168 ...... 164, 205, 235, 236 Sulthiame ...... 82 - 87, 138 - 139, 148 - 149, Trisialotransferrin ...... 12 - 17, 237

Olanzapine ...... 92 - 93, 177, 202, 207, 233, 238 Pregabaline-d4 ...... 168 ...... 164, 176, 205, 235, 236 Tryptophane ...... 202, 232 Opipramol ...... 140 - 141, 150 - 151, 164, 204, 235 Primidone ...... 82 - 85, 138 - 139, 148 - 149, Tacrolimus ...... 130 - 131, 166, 209, 241 Tyrosine ...... 154 - 157, 202, 232, 240

13 13 Opipramol-d4 ...... 168 ...... 164, 176, 205, 235, 236 Tacrolimus- Cd2 ...... 170 Tyrosine- C6 ...... 168

Ornithine ...... 154 - 157, 202, 232, 240 Primidone-d5 ...... 168 Taurine ...... 202, 232 Ubiquinone (Coenzyme Q10) ...... 54 - 55, 177, 203, 234

2 Ornithine- H6 ...... 168 17-Hydroxy-Progesterone ...... 207, 239 Temazepam ...... 134 - 135, 144 - 145, 165, 206, 237 Urea ...... 202, 232

ortho-Cresol ...... 96 - 97, 201, 231 21-Hydroxy-Progesterone Temazepam-d5 ...... 169 Uroporphyrin I ...... 50 - 51, 180, 201, 232 Oxazepam ...... 134 - 135, 144 - 145, 165, 206, 237 (11-Doxycorticosterone) ...... 207, 239 Testosterone ...... 207, 239 Valine ...... 154 - 157, 202, 232, 240

2 Oxazepam-d5 ...... 169 Proline ...... 154 - 157, 202, 232, 240 Tetradecanoylcarnitine (C14-Carnitine) ...... 154 - 157, 240 Valine- H8 ...... 168

13 2 2 Oxcarbazepine ...... 138 - 139, 148 - 149, 164, Proline- C5 ...... 168 Tetradecanoylcarnitine- H3 ( H3-C14) ...... 168 Valproic acid ...... 138 - 139, 148 - 149, ...... 205, 235, 236 Propionylcarnitine (C3-Carnitine) ...... 154 - 157, 240 Tetrasialotransferrin ...... 12 - 17, 237 ...... 164, 205, 235, 236

2 2 Oxcarbazepine-d4 ...... 168 Propionylcarnitine- H3 ( H3-C3) ...... 168 Tetrazepam ...... 134 - 135, 144 - 145, 165, 206, 237 Valproic acid-d6 ...... 168 Paliperidone (9-Hydroxy-Risperidone) ...... 92 - 93, 177, Protriptyline ...... 136 - 137, 146 - 147, 167, 208, 239 Thallium ...... 201, 204, 208, 209, Vanadium ...... 201, 204, 208, 232, 235, 239 ...... 203, 207, 233, 238 Pyridoxal (Vitamin B6) ...... 66 - 69, 180, 209, 241 ...... 232, 235, 239, 241 Vanillylmandelic acid (VMA) ...... 34 - 37, 177, 200, Palladium ...... 201, 204, 207, 208, Pyridoxal-5-phosphate Theobromine ...... 78 - 79, 176, 202, 232 ...... 203, 230, 233 ...... 232, 235, 238, 239 (Vitamin B6) ...... 62 - 63, 66 - 69, 180, 209, 241 Theophylline ...... 78 - 79, 138 - 139, 148 - 149, Venlafaxine ...... 140 - 141, 150 - 151, 164, Paroxetine ...... 140 - 141, 150 - 151, 164, Quetiapine ...... 92 - 93, 177, 202, 207, 233, 238 ...... 164, 176, 202, 205, 232, 236 ...... 204, 207, 235, 238

...... 204, 207, 235, 239 Raltegravir ...... 164, 205, 236 Theophylline-d6 ...... 168 Venlafaxine, O-Desmethyl- ...... 140 - 141, 150 - 151,

Paroxetine-d4 ...... 168 Raltegravir-d3 ...... 169 Thiaminepyrophosphate ...... 164, 204, 235

3-PBA (3-Phenoxybenzoic acid) ...... 231 Reboxetine ...... 140 - 141, 150 - 151, 164, 204, 235 (TPP, Vitamin B1) ...... 62 - 63, 68 - 69, 180, 209, 241 Venlafaxine-d6 ...... 168

PBG (Porphobilinogen) ...... 50 - 51, 108 - 111, Reboxetine-d5 ...... 168 threo-Dihydro-Bupropion ...... 204, 207, 235, 238 Vigabatrine ...... 138 - 139, 148 - 149,

...... 180, 201, 232 Retigabine ...... 138 - 139, 148 - 149, threo-Dihydro-Bupropion-d9 ...... 168 ...... 164, 205, 235, 236 PEMA (Phenylethylmalonamide) ...... 80 - 81, 138 - 139, ...... 164, 205, 235, 236 Threonine ...... 202, 232 Vitamin A (Retinol, all-trans) ...... 60 - 61, 180, 208, 240

...... 148 - 149, 164, 176, 205, 235, 236 Retigabine-d4 ...... 168 Tiagabine ...... 138 - 139, 148 - 149, Vitamin B1 ...... 62 - 63, 68 - 69, 180, 209, 241

PEMA-d5 ...... 168 Retinol, all-trans (Vitamin A) ...... 60 - 61, 180, 208, 240 ...... 164, 205, 235, 236 Vitamin B2 ...... 64 - 65, 68 - 69, 180, 209, 241

Pentacarboxyporphyrin I ...... 50 - 51, 180, 201, 232 Rilpivirine ...... 164, 205, 236 Tiagabine-d6 ...... 168 Vitamin B6 ...... 62 - 63, 66 - 69, 180, 209, 241 Pentachlorophenol ...... 201, 231 Risperidone ...... 92 - 93, 177, 203, 207, 233, 238 Tin ...... 201, 204, 208, 209, Vitamin C ...... 58 - 59, 208, 239 Pentasialotransferrin ...... 12 - 17, 237 Ritalinic acid ...... 140 - 141, 150 - 151, 164, 204, 235 ...... 232, 235, 239, 241 Vitamin D2 ...... 70 - 73, 126 - 127, Perampanel ...... 138 - 139, 148 - 149, 164, 205, 235, 236 Ritonavir ...... 164, 205, 236 Tipranavir ...... 164, 205, 236 ...... 167, 181, 208, 239

Perazine ...... 207, 238 Ritonavir-d6 ...... 169 Tipranavir-d4 ...... 169 Vitamin D3 ...... 70 - 73, 126 - 127, Phenobarbital ...... 82 - 85, 138 - 139, 148 - 149, Rufinamide ...... 82 - 85, 138 - 139, 148 - 149, Titanium ...... 204, 208, 235, 239 ...... 167, 181, 208, 239 ...... 164, 176, 205, 235, 236 ...... 164, 176, 205, 235, 236 α-Tocopherol (Vitamin E) ...... 60 - 61, 180, 208, 240 Vitamin E (α-Tocopherol) ...... 60 - 61, 180, 208, 240 Recipe_Katalog_16-17_Ansicht.qxd:Recipe_Katalog.qxd 21.04.16 12:17 Seite 248

Index

VMA (Vanillylmandelic acid) ...... 34 - 37, 177, 200, ...... 203, 230, 233 Voriconazole ...... 202, 233 Zaleplon ...... 134 - 135, 144 - 145, 165, 206, 237 Zinc ...... 201, 204, 208, 209, ...... 232, 235, 239, 241 Ziprasidone ...... 207, 238 Zolpidem ...... 134 - 135, 144 - 145, 165, 206, 237

Zolpidem-d6 ...... 169 Zonisamide ...... 82 - 85, 138 - 139, 148 - 149, ...... 164, 176, 205, 235, 236

15 Zonisamide-d4 N ...... 168 Zopiclone ...... 134 - 135, 144 - 145, 165, 206, 237 Zopiclone + ACP ...... 134 - 135, 144 - 145, 165, 206, 237

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