186 (10)

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The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. VOL. 186 | NO. 10 | May 15, 2011 | Pages 5525–6068

5525 IN THIS ISSUE

Brief Reviews 5527 GM-CSF–Based Fusion Cytokines as Ligands for Immune Modulation Patrick Williams and Jacques Galipeau

Cutting Edge

5533 Cutting Edge: PHLPP Regulates the Development, Function, and Molecular Signaling Pathways of Downloaded from Regulatory T Cells Scott J. Patterson, Jonathan M. Han, Rosa Garcia, Kiran Assi, Tianyan Gao, Audrey O’Neill, Alexandra C. Newton, and Megan K. Levings

5538 Cutting Edge: NKG2D-Dependent Cytotoxicity Is Controlled by Ligand Distribution in the Target Cell

Membrane http://www.jimmunol.org/ Emily Martinez, Joseph A. Brzostowski, Eric O. Long, and Catharina C. Gross

5543 Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing Lucy V. Norling, Matthew Spite, Rong Yang, Roderick J. Flower, Mauro Perretti, and Charles N. Serhan

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION by guest on September 30, 2021 5549 Hepatic Stellate Cells Function as Regulatory Bystanders Shintaro Ichikawa, Daniel Mucida, Aaron J. Tyznik, Mitchell Kronenberg, and Hilde Cheroutre

5556 CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses Nina Chevalier, David Jarrossay, Edwin Ho, Danielle T. Avery, Cindy S. Ma, Di Yu, Federica Sallusto, Stuart G. Tangye, and Charles R. Mackay

On the cover: The first specific TCR–peptide interaction to be identified was a charge–charge interaction between TCR and the central lysine of the cytochrome c peptide presented by I-Ek (Jorgensen et al., 1992). This and several other coordinat- ing interactions are shown for the 226 TCR, a relative of the well-studied 5c.c7 and 2B4 TCRs. Newell, E. W., L. K. Ely, A. C. Kruse, P. A. Reay, S. N. Rodriguez, A. Lin, M. S. Kuhns, K. C. Garcia, and M. M. Davis. 2011. Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-Ek. J. Immunol. 186: 5823–5832.

The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists, Inc., 9650 Rockville Pike, Bethesda, MD 20814-3994, Phone: 301-634-7197, Fax: 301-634-7829. Subscription terms: New subscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices and details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/ membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issues can be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/pdf/single_issue_purchase.pdf). Reprints of individual articles are available only from authors. Periodicals postage paid at Bethesda, MD 20814-3994, and at additional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes 60 days in advance to The Journal of Immunology, Subscription Department, 9650 Rockville Pike, Bethesda, MD 20814-3994. Copyright Ó 2011 by The American Association of Immunologists, Inc. 5569 Mice Lacking Endogenous IL-10–Producing Regulatory B Cells Develop Exacerbated Disease and Present with an Increased Frequency of Th1/Th17 but a Decrease in Regulatory T Cells Natalie A. Carter, Rita Vasconcellos, Elizabeth C. Rosser, Calogero Tulone, Alba Mun~oz-Suano, Masahito Kamanaka, Michael R. Ehrenstein, Richard A. Flavell, and Claudia Mauri

5580 Blockade of CTLA-4 Decreases the Generation of Multifunctional Memory CD4+ T Cells In Vivo Marion Rudolph, Katrin Hebel, Yoshinori Miyamura, Emanual Maverakis, and Monika C. Brunner-Weinzierl

5590 Potential Role of Invariant NKT Cells in the Control of Pulmonary Inflammation and CD8+ T Cell Response during Acute Influenza A Virus H3N2 Pneumonia Christophe Paget, Stoyan Ivanov, Josette Fontaine, Fany Blanc, Muriel Pichavant, Joelle Renneson, Emilie Bialecki, Julien Pothlichet, Catherine Vendeville, Giovanna Barba-Speath, Michel-Rene Huerre, Christelle Faveeuw, Mustapha Si-Tahar, and Franc¸ois Trottein

5603 Plexin-D1 Is a Novel Regulator of Germinal Centers and Humoral Immune Responses Eda K. Holl, Brian P. O’Connor, T. Matt Holl, Kelly E. Roney, Albert G. Zimmermann, Sushmita Jha, Garnett Kelsoe, and Jenny P.-Y. Ting

5612 Peripheral T Cells Re-Enter the Thymus and Interfere with Central Tolerance Induction Downloaded from Stephanie L. Edelmann, Peggy Marconi, and Thomas Brocker

5620 Tolerance Induction of IgG+ Memory B Cells by T Cell-Independent Type II Antigens Kei Haniuda, Takuya Nojima, Kyosuke Ohyama, and Daisuke Kitamura

5629 Epicutaneous Immunotherapy Results in Rapid Allergen Uptake by Dendritic Cells through Intact Skin and http://www.jimmunol.org/ Downregulates the Allergen-Specific Response in Sensitized Mice Vincent Dioszeghy, Lucie Mondoulet, Veronique Dhelft, Melanie Ligouis, Emilie Puteaux, Pierre-Henri Benhamou, and Christophe Dupont

5638 Noncanonical K27-Linked Polyubiquitination of TIEG1 Regulates Foxp3 Expression and Tumor Growth Dong-Jun Peng, Minghui Zeng, Ryuta Muromoto, Tadashi Matsuda, Kazuya Shimoda, Malayannan Subramaniam, Thomas C. Spelsberg, Wei-Zen Wei, and K. Venuprasad by guest on September 30, 2021 5648 Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells Emily Hams, Mark J. McCarron, Sylvie Amu, Hideo Yagita, Miyuki Azuma, Lieping Chen, and Padraic G. Fallon

5656 Thymic Stromal Lymphopoietin Is a Key Mediator of Breast Cancer Progression Purevdorj B. Olkhanud, Yrina Rochman, Monica Bodogai, Enkhzol Malchinkhuu, Katarzyna Wejksza, Mai Xu, Ronald E. Gress, Charles Hesdorffer, Warren J. Leonard, and Arya Biragyn

5663 Vaccine-Induced CD8+ T Lymphocytes of Rhesus Monkeys Recognize Variant Forms of an HIV Epitope but Do Not Mediate Optimal Functional Activity Sandrine L. Hulot, Evan M. Cale, Bette T. Korber, and Norman L. Letvin

5675 HLA-A*7401–Mediated Control of HIV Viremia Is Independent of Its Linkage Disequilibrium with HLA-B*5703 Philippa C. Matthews, Emily Adland, Jennifer Listgarten, Alasdair Leslie, Nompumelelo Mkhwanazi, Jonathan M. Carlson, Mikkel Harndahl, Anette Stryhn, Rebecca P. Payne, Anthony Ogwu, Kuan-Hsiang Gary Huang, John Frater, Paolo Paioni, Henrik Kloverpris, Pieter Jooste, Dominique Goedhals, Cloete van Vuuren, Dewald Steyn, Lynn Riddell, Fabian Chen, Graz Luzzi, Thambiah Balachandran, Thumbi Ndung’u, Søren Buus, Mary Carrington, Roger Shapiro, David Heckerman, and Philip J. R. Goulder

5687 Advanced Glycation End Products Inhibit Both Infection and Transmission In Trans of HIV-1 from Monocyte-Derived Dendritic Cells to Autologous T Cells Nadine Nasreddine, Chloe Borde, Joel€ Gozlan, Laurent Belec, Vincent Marechal, and Hakim Hocini

5696 Plasmacytoid Dendritic Cells Play a Major Role in Apoptotic Leukocyte-Induced Immune Modulation Francis Bonnefoy, Sylvain Perruche, Melanie Couturier, Abdeslem Sedrati, Yunwei Sun, Pierre Tiberghien, Beatrice Gaugler, and Philippe Saas 5706 The PTAP Sequence within the p6 Domain of Human Immunodeficiency Virus Type 1 Gag Regulates Its Ubiquitination and MHC Class I Antigen Presentation Sabine Hahn, Christian Setz, Julia Wild, and Ulrich Schubert

5719 Molecular Mechanisms of Induction of Antigen-Specific Allograft Tolerance by Intranasal Peptide Administration Katy Derbyshire, Caroline Addey, David Coe, Daniel W. Stuckey, Hasan Muezzin, Jason A. Bubier, Daniel J. Shaffer, Derry C. Roopenian, Jian-Guo Chai, and Diane M. Scott

5729 Bcl-2 Allows Effector and Memory CD8+ T Cells To Tolerate Higher Expression of Bim Sema Kurtulus, Pulak Tripathi, Maria E. Moreno-Fernandez, Allyson Sholl, Jonathan D. Katz, H. Leighton Grimes, and David A. Hildeman

5738 Caspase-1–Processed Cytokines IL-1b and IL-18 Promote IL-17 Production by gd and CD4 T Cells That Mediate Autoimmunity Stephen J. Lalor, Lara S. Dungan, Caroline E. Sutton, Sharee A. Basdeo, Jean M. Fletcher, and Kingston H. G. Mills

5749 MHC Class II-Restricted Interaction between Thymocytes Plays an Essential Role in the Production of Innate CD8+ T Cells Hye Sook Min, You Jeong Lee, Yoon Kyung Jeon, Eun Ji Kim, Byung Hyun Kang, Kyeong Cheon Jung, Cheong-Hee Chang, Downloaded from and Seong Hoe Park

5758 Proinflammatory Environment Dictates the IL-17–Producing Capacity of Human Invariant NKT Cells Lucia Moreira-Teixeira, Mariana Resende, Maryaline Coffre, Odile Devergne, Jean-Philippe Herbeuval, Olivier Hermine, Elke Schneider, Lars Rogge, Frank M. Ruemmele, Michel Dy, Anabela Cordeiro-da-Silva, and Maria C. Leite-de-Moraes http://www.jimmunol.org/

5766 NK Cell-Depleting Anti-Asialo GM1 Antibody Exhibits a Lethal Off-Target Effect on Basophils In Vivo Hideto Nishikado, Kaori Mukai, Yohei Kawano, Yoshiyuki Minegishi, and Hajime Karasuyama

5772 TLR4 Signaling via MyD88 and TRIF Differentially Shape the CD4+ T Cell Response to Porphyromonas gingivalis Hemagglutinin B Dalia E. Gaddis, Suzanne M. Michalek, and Jannet Katz

5784 Differential Outcome of IL-2/Anti–IL-2 Complex Therapy on Effector and Memory CD8+ T Cells by guest on September 30, 2021 following Vaccination with an Adenoviral Vector Encoding EBV Epitopes Corey Smith, Michelle Martinez, Jesse Peet, and Rajiv Khanna

MOLECULAR AND STRUCTURAL IMMUNOLOGY 5791 MEKK3 Regulates IFN-g Production in T Cells through the Rac1/2-Dependent MAPK Cascades Xiaofang Wang, Fan Zhang, Fanping Chen, Dou Liu, Yi Zheng, Yongliang Zhang, Chen Dong, and Bing Su

5801 Promyelocytic Leukemia Zinc Finger Turns on the Effector T Cell Program without Requirement for Agonist TCR Signaling Adam K. Savage, Michael G. Constantinides, and Albert Bendelac

5807 Two Sorting Motifs, a Ubiquitination Motif and a Tyrosine Motif, Are Involved in HIV-1 and Simian Immunodeficiency Virus Nef-Mediated Receptor Endocytosis Catherine Yi Cai, Xiaoping Zhang, Patrick J. Sinko, Steven J. Burakoff, and Yong-Jiu Jin

5815 M-Ficolin Interacts with the Long Pentraxin PTX3: A Novel Case of Cross-Talk between Soluble Pattern-Recognition Molecules Evelyne Gout, Christine Moriscot, Andrea Doni, Chantal Dumestre-Perard, Monique Lacroix, Julien Perard, Guy Schoehn, Alberto Mantovani, Gerard J. Arlaud, and Nicole M. Thielens

5823 Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c–I-Ek Evan W. Newell, Lauren K. Ely, Andrew C. Kruse, Philip A. Reay, Stephanie N. Rodriguez, Aaron E. Lin, Michael S. Kuhns, K. Christopher Garcia, and Mark M. Davis

5833 TGF-bi Promotes Islet b-Cell Function and Regeneration Bing Han, Shijie Qi, Bing Hu, Hongyu Luo, and Jiangping Wu IMMUNOGENETICS 5845 Epistatic Suppression of Fatal Autoimmunity in New Zealand Black Bicongenic Mice Christina Loh, Evelyn Pau, Ginette Lajoie, Timothy T. Li, Yuriy Baglaenko, Yui-Ho Cheung, Nan-Hua Chang, and Joan E. Wither

HOST DEFENSE 5854 EBV-Specific CD8+ T Cells from Asymptomatic Pediatric Thoracic Transplant Patients Carrying Chronic High EBV Loads Display Contrasting Features: Activated Phenotype and Exhausted Function Camila Macedo, Steven A. Webber, Albert D. Donnenberg, Iulia Popescu, Yun Hua, Michael Green, David Rowe, Louise Smith, Maria M. Brooks, and Diana Metes

5863 CD40-Modulated Dual-Specificity Phosphatases MAPK Phosphatase (MKP)-1 and MKP-3 Reciprocally Regulate Leishmania major Infection Neetu Srivastava, Raki Sudan, and Bhaskar Saha

5873 Plasmodium–Host Interactions Directly Influence the Threshold of Memory CD8 T Cells Required for Protective Immunity Nathan W. Schmidt, Noah S. Butler, and John T. Harty Downloaded from 5885 Transcriptional Suppression of IL-27 Production by Mycobacterium tuberculosis-Activated p38 MAPK via Inhibition of AP-1 Binding Jidong Zhang, Xuesong Qian, Huan Ning, Christopher S. Eickhoff, Daniel F. Hoft, and Jianguo Liu

5896 Escherichia coli Heat-Labile Enterotoxin Promotes Protective Th17 Responses against Infection by Driving Innate IL-1 and IL-23 Production http://www.jimmunol.org/ Corinna F. Brereton, Caroline E. Sutton, Padraig J. Ross, Yoichiro Iwakura, Mariagrazia Pizza, Rino Rappuoli, Ed C. Lavelle, and Kingston H. G. Mills

5907 The Integrins Mac-1 and a4b1 Perform Crucial Roles in Neutrophil and T Cell Recruitment to Lungs during Streptococcus pneumoniae Infection Aras Kadioglu, Katia De Filippo, Mathieu Bangert, Vitor E. Fernandes, Luke Richards, Kristian Jones, Peter W. Andrew, and Nancy Hogg by guest on September 30, 2021

5916 Synergistic Interactions of TLR2/6 and TLR9 Induce a High Level of Resistance to Lung Infection in Mice Jeffrey M. Duggan, Dahui You, Jeffrey O. Cleaver, Derek T. Larson, R. Joshua Garza, Francisco A. Guzman Pruneda, Michael J. Tuvim, Jiexin Zhang, Burton F. Dickey, and Scott E. Evans

5927 Prolonged Antitumor NK Cell Reactivity Elicited by CXCL10-Expressing Dendritic Cells Licensed by CD40L+CD4+ Memory T Cells Kanako Shimizu, Miki Asakura, and Shin-ichiro Fujii

5938 Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7–MyD88-Dependent Signaling Pathway Sophia Davidson, Gerard Kaiko, Zhixuan Loh, Amit Lalwani, Vivian Zhang, Kirsten Spann, Shen Yun Foo, Nicole Hansbro, Satoshi Uematsu, Shizuo Akira, Klaus I. Matthaei, Helene F. Rosenberg, Paul S. Foster, and Simon Phipps

2 2 5949 An Aberrant Thymus in CCR5 / Mice Is Coupled with an Enhanced Adaptive Immune Response in Fungal Infection Danielle N. Kroetz and George S. Deepe, Jr.

INFLAMMATION 5956 Prevention of Bone Marrow Cell Apoptosis and Regulation of Hematopoiesis by Type I IFNs during Systemic Responses to Pneumocystis Lung Infection David Taylor, Michelle Wilkison, Jovanka Voyich, and Nicole Meissner

5968 Vitamin D and the Regulation of Placental Inflammation Nancy Q. Liu, Amber T. Kaplan, Venu Lagishetty, Yuxin B. Ouyang, Yi Ouyang, Charles F. Simmons, Ozlem Equils, and Martin Hewison 5975 Dopamine D1-Like Receptor Antagonist Attenuates Th17-Mediated Immune Response and Ovalbumin Antigen-Induced Neutrophilic Airway Inflammation Kazuyuki Nakagome, Mitsuru Imamura, Hirokazu Okada, Kimito Kawahata, Tsutomu Inoue, Kumiko Hashimoto, Hiroaki Harada, Takehiro Higashi, Rie Takagi, Kazuhisa Nakano, Koichi Hagiwara, Minoru Kanazawa, Makoto Dohi, Makoto Nagata, and Sho Matsushita

5983 Enhanced Nerve–Mast Cell Interaction by a Neuronal Short Isoform of Cell Adhesion Molecule-1 Man Hagiyama, Tadahide Furuno, Yoichiroh Hosokawa, Takanori Iino, Takeshi Ito, Takao Inoue, Mamoru Nakanishi, Yoshinori Murakami, and Akihiko Ito

5993 Colonic Eosinophilic Inflammation in Experimental Colitis Is Mediated by Ly6Chigh CCR2+ Inflammatory Monocyte/Macrophage-Derived CCL11 Amanda Waddell, Richard Ahrens, Kris Steinbrecher, Burke Donovan, Marc E. Rothenberg, Ariel Munitz, and Simon P. Hogan

6004 Subcellular Localization and Role of Lipin-1 in Human Macrophages Mart´in Valdearcos, Esperanza Esquinas, Clara Meana, Luis Gil-de-Gomez, Carlos Guijas, Jesus Balsinde, and Mar´ia A. Balboa

6014 The Tyrosine Kinase BMX Is an Essential Mediator of Inflammatory Arthritis in a Kinase-Independent Downloaded from Manner Marie Gottar-Guillier, Francis Dodeller, Dieter Huesken, Vadim Iourgenko, Craig Mickanin, Mark Labow, Samuel Gaveriaux, Bernd Kinzel, Matthias Mueller, Kari Alitalo, Amanda Littlewood-Evans, and Bruno Cenni

CLINICAL IMMUNOLOGY http://www.jimmunol.org/ 6024 Autoantibody-Mediated IL-6–Dependent Endothelin-1 Elevation Underlies Pathogenesis in a Mouse Model of Preeclampsia Cissy Chenyi Zhou, Roxanna A. Irani, Yingbo Dai, Sean C. Blackwell, M. John Hicks, Susan M. Ramin, Rodney E. Kellems, and Yang Xia

6035 FAS Haploinsufficiency Is a Common Disease Mechanism in the Human Autoimmune Lymphoproliferative Syndrome

Hye Sun Kuehn, Iusta Caminha, Julie E. Niemela, V. Koneti Rao, Joie Davis, Thomas A. Fleisher, and Joao~ B. Oliveira by guest on September 30, 2021

6044 Impaired Response to Influenza Vaccine Associated with Persistent Memory B Cell Depletion in Non-Hodgkin’s Lymphoma Patients Treated with Rituximab-Containing Regimens Davide Bedognetti, Gabriele Zoppoli, Carlotta Massucco, Elisa Zanardi, Simonetta Zupo, Andrea Bruzzone, Mario Roberto Sertoli, Enrico Balleari, Omar Racchi, Marco Messina, Graziano Caltabiano, Giancarlo Icardi, Paolo Durando, Francesco M. Marincola, Francesco Boccardo, Manlio Ferrarini, Filippo Ansaldi, and Andrea De Maria

6056 Human Type 1 Diabetes Is Associated with T Cell Autoimmunity to Zinc Transporter 8 MyLinh Dang, Jennifer Rockell, Rebecca Wagner, Janet M. Wenzlau, Liping Yu, John C. Hutton, Peter A. Gottlieb, and Howard W. Davidson

CORRECTIONS 6064 Correction: The Magnitude of the Antibody and Memory B Cell Responses during Priming with a Protein-Polysaccharide Conjugate Vaccine in Human Infants Is Associated with the Persistence of Antibody and the Intensity of Boster Response Geraldine Blanchard Rohner, Matthew D. Snape, Dominic F. Kelly, Tessa John, Anita Morant, Ly-Mee Yu, Astrid Borkowski, Francesca Ceddia, Ray Borrow, Claire-Anne Siegrist, and Andrew J. Pollard

6065 AUTHOR INDEX