DOCSLIB.ORG

Catenin Expression in the Müllerian Duct Mesenchyme

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Catenin Expression in the Müllerian Duct Mesenchyme Focal Müllerian duct retention in male mice with constitutively activated β-catenin expression in the Müllerian duct mesenchyme Pradeep S. Tanwara, LiHua Zhanga, Yoshihiro Tanakaa, Makoto M. Taketob, Patricia K. Donahoec,1, and Jose M. Teixeiraa,1 aVincent Center For Reproductive Biology, Department of Obstetrics, Gynecology and Reproductive Biology, and cPediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; and bDepartment of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan Contributed by Patricia K. Donahoe, August 4, 2010 (sent for review April 23, 2010) Müllerian-inhibiting substance (MIS), which is produced by fetal β-catenin stabilization or a Wnt/Ca2+ pathway (12–14). The sta- Sertoli cells shortly after commitment of the bipotential gonads to bility of free β-catenin in the cytoplasm is regulated by a de- testicular differentiation, causes Müllerian duct (MD) regression. In struction complex formed by axin, adenomatosis polyposis the fetal female gonads, MIS is not expressed and the MDs will complex (APC), casein kinase 1, and glycogen synthase kinase 3-β differentiate into the internal female reproductive tract. We have (GSK3β), which binds and phosphorylates β-catenin, making it investigated whether dysregulated β-catenin activity affects MD re- a target for ubiquitination and degradation. During canonical Wnt gression by expressing a constitutively activated nuclear form of signaling, β-catenin escapes this complex and translocates to the β-catenin in the MD mesenchyme. We show that constitutively acti- nucleus to activate the transcription of various targeted genes in vated (CA) β-catenin causes focal retention of MD tissue in the epi- concert with members of the TCF/LEF family of transcription didymides and vasa deferentia. In adult mutant mice, the retained factors. Nuclear β-catenin expression in the MD mesenchyme has MD tissues express α-smooth muscle actin and desmin, which are been suggested as a mediator of MIS-induced MD regression (15). markers for uterine differentiation. MD retention inhibited the fold- We have previously shown that expression of a tissue-specific, ing complexity of the developing epididymides and usually led to constitutively activated (CA) form of β-catenin (16) driven by Cre BIOLOGY obstructive azoospermia by spermatoceles. The MDs of urogenital in the Amhr2 locus (AMHR2-Cre) did not result in MD regression DEVELOPMENTAL ridges from mutant female embryos showed less regression with in female mice (17), suggesting that β-catenin is not sufficient added MIS in organ culture compared with control MDs when ana- for regression. lyzed by whole mount in situ hybridization for Wnt7a as a marker We have previously reported that expression of CA β-catenin for the MD epithelium. CA β-catenin did not appear to affect expres- restricted to the uterine stroma and myometrium leads to myo- sion of either MIS in the embryonic testes or its type II receptor metrial smooth muscle cell hyperplasia and development of mes- (AMHR2) in the MD mesenchyme nor did it inhibit pSmad1/5/8 nu- enchymal tumors in murine uteri (17). We and others have also clear accumulation, suggesting that dysregulated β-catenin must in- shown that CA β-catenin causes sterility in males by inhibiting hibit MD regression independently of MIS signaling. These studies postnatal Sertoli maturation and spermatogenesis (18–20). Given suggest that dysregulated Wnt/β-catenin signaling in the MD mes- the requirement for Wnt signaling in MD development (21) and enchyme might also be a contributing factor in persistent Müllerian the relative paucity of reports linking Wnt signaling and Wolffian duct syndrome, a form of male pseudohermaphroditism, and devel- duct (WD) differentiation, we examined whether dysregulated opment of spermatoceles. β-catenin activity in the adjacent MD mesenchyme affected normal WD development into the epididymis, vas deferens, and seminal anti-Müllerian hormone | epididymis | Mullerian inhibiting substance type II vesicles (22, 23). We show that CA β-catenin expression in the MD receptor (MISRII or MISR2) | spermatocele | epididymis mesenchyme results in focal MD retention and adjacent WD ob- struction, which leads to azoospermia and infertility secondary to hortly after commitment of the bipotential embryonic mam- seminiferous tubule degeneration and defective spermatogenesis Smalian gonadal ridge to male development, Sertoli cells dif- that develops later in the adult (18, 19). ferentiate in the testes and produce Müllerian-inhibiting substance [MIS; also known as anti-Müllerian hormone (AMH)], a TGFβ Results β family member that causes Müllerian duct (MD) regression in To investigate whether dysregulated CA -catenin expression in males. MIS is not produced by the embryonic female gonads; thus, the MD mesenchyme affects differentiation of the adjacent WD, β-catenin the MDs differentiate into the oviduct, uterus, cervix, and upper we generated mutant mice that lack exon 3 of the gene Ctnnb1fl(ex3) portion of the vagina (1, 2). Persistent Müllerian duct syndrome ( ), which would otherwise contain the serine/threo- β (PMDS) is a form of human male pseudohermaphroditism that is nine residues normally phosphorylated by GSK3 before ubiq- the result of retained female reproductive tract tissue. Homozy- uitination (16), by mating with mice that express Cre recombinase Amhr2 fi β gous deletion or knockdown of either MIS (3); its type I receptors, in the locus (4). Con rmation of nuclear -catenin ex- pression in the MD mesenchyme between the WD and MD of both BMPR1A (Alk3) (4) and ACVR1 (Alk2) (5, 6); or type II receptor, Δ(ex3) male and female urogenital ridges of Amhr2-Cre;Ctnnb1 mice AMHR2 (also known as MISRII) (7), in mice leads to retention of Ctnnb1fl(ex3) the MDs, and mutations in either MIS or MIS receptors are is shown in Fig. 1. In the urogenital ridges of control thought to account for 85% of patients with PMDS (8). Proper MD differentiation in females requires Wnt signaling. For example, the uteri of mice with a deletion of Wnt7a are de- Author contributions: P.S.T. and J.M.T. designed research; P.S.T., L.Z., and Y.T. performed fi research; M.M.T. and P.K.D. contributed new reagents/analytic tools; P.S.T., M.M.T., P.K.D., cient in myometrial tissue, endometrial glands, and oviductal and J.M.T. analyzed data; and P.S.T., P.K.D., and J.M.T. wrote the paper. coiling (9, 10), and mice lacking Wnt5a have shortened uterine The authors declare no conflict of interest. horns and defective development of cervices and vaginas (11). 1To whom correspondence may be addressed. E-mail: [email protected] or Wnts bind to their respective cell surface frizzled or low density [email protected]. lipoprotein-related protein (LRP) receptors and signal through This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10. two intracellular pathways, a canonical pathway induced by 1073/pnas.1011606107/-/DCSupplemental. www.pnas.org/cgi/doi/10.1073/pnas.1011606107 PNAS Early Edition | 1of6 Downloaded by guest on October 2, 2021 mice, we observed membranous expression of β-catenin in the AB MD epithelium at embryonic day (E) 14.5 of both females (Fig. 1 A and C) and males (Fig. 1 E and G). In ridges from Amhr2-Cre; Δ(ex3) Ctnnb1 mice, membranous β-catenin continued to be ex- pressed in the MD epithelium and strong nuclear β-catenin ex- pression was observed the MD mesenchyme (Fig. 1 B, D, F,andH). By P1, the MD has completely regressed in control male embryos (Fig. 2 A and B), but MD remnants are still observed in the epi- Δ(ex3) didymides and vasa deferentia of Amhr2-Cre;Ctnnb1 males (Fig. 2 C and D), which persisted through adulthood (Fig. 2 E and F C D and Fig. S1). Whereas membranous β-catenin expression was observed in epididymal epithelia, predominantly nuclear β-catenin was ob- served in the cells surrounding the retained MD-derived tissue of Δ( Amhr2-Cre;Ctnnb1 ex3) postnatal mice (Fig. 3 A and B). We also observed elevated expression of TCF1, LEF1, and cyclinD1, which have been shown to be up-regulated by Wnt/β-catenin signaling (24–28), in the P1 remnants of MD mesenchyme in the mutants E F compared with the normal surrounding tissue (Fig. S2), indicating that the nuclear β-catenin we observed was functionally active. The retained MD mesenchyme differentiates into an enlarged, simple tube-like structure resembling a uterus that expresses α-smooth muscle actin (αSMA) and desmin (Fig. 3 C and D), which are in- dicative of myometrium and endometrial stroma, respectively, but Fig. 2. Focal inhibition of Müllerian duct regression in mice with constitu- AB tive activated β-catenin in the MD mesenchyme. Gross analyses of male re- productive tracts of a control Amhr2-Cre/+;YFP mouse (A and B) show complete MD regression by P1 and that of an Amhr2-Cre/+;Ctnnb1Δ(ex3)/+; YFP mouse show bilateral focal retention (C and D, indicated with arrow- heads). Müllerian duct tissue is visible along side the epididymides of PND20 mutant mice (E and F, indicated with arrowheads) but not in control epi- didymides. T, testis; E, epididymis; V, vasa deferentia; Ex3, Amhr2-Cre/+; Ctnnb1Δ(ex3)/+;YFP; C, control. C D without endometrial glands and luminal folds, and is similarly observed in mice homozygously deleted for either MIS or one of its receptors (3, 4). Histological analyses showed that the remaining Δ(ex3) MD-derived tissue in Amhr2-Cre;Ctnnb1 inhibited coiling and integrity of the ducts in the caput and corpus regions of the epi- didymides (Fig. 3 E–H). Analysis of cytokeratin expression also showed that the integrity of the pseudostratified columnar ductal epithelium in the cauda epididymides was compromised near the EF retained MD tissue in mutant mice (Fig.
Load more

Recommended publications
  • Imaging Description of Extragenital Müllerian Adenosarcoma: a Case Report Descrição Da Imagem Do Adenosarcoma Mülleriano Extragenital: Relato De Caso
    Published online: 2018-12-12 THIEME 124 Case Report Imaging Description of Extragenital Müllerian Adenosarcoma: A Case Report Descrição da imagem do adenosarcoma mülleriano extragenital: relato de caso Annalisa Mone1 Piergiorgio Iannone2 1 Department of Radiology, University of Verona, Verona, Italy Address for correspondence Annalisa Mone, MD, Reparto di 2 Section of Obstetrics and Gynecology, Department of Morphology, Radiologia, Policlinico G.B. Rossi, Università Degli Studi di Verona, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy Piazzale LA Scuro, 10, 37134, Verona, Italy (e-mail: [email protected]). Rev Bras Ginecol Obstet 2019;41:124–128. Abstract Müllerian adenosarcoma is a very rare gynecological disease, comprising 5% of uterine sarcomas. Extragenital localizations are even rarer. We report a very interesting case of Keywords a 27-year-old woman complaining of pelvic pain, with a subsequent diagnosis of ► extragenital müllerian extragenital Müllerian adenosarcoma. This is the first case reported in the literature adenosarcoma with a complete and wide imaging description. Even if rare, Müllerian adenosarcoma ► computed should be hypothesized in case of young female patients presenting with suspicious tomography pelvic mass. ► pelvic mass ► uterine sarcoma Resumo O adenosarcoma Mülleriano é uma doença ginecológica muito rara, compreendendo 5% dos sarcomas uterinos. Localizações extragenitais são ainda mais raras. Relatamos Palavras-chave um caso muito interessante de uma mulher de 27 anos queixando-se de dor pélvica ► adenosarcoma com diagnóstico subsequente de adenosarcoma Mülleriano extragenital. Este é o mülleriano primeiro caso relatado na literatura com uma descrição completa e ampla de imagem. extragenital Mesmo que raro, o adenosarcoma Mülleriano deve ser hipotetizado no caso de ► fi tomogra a pacientes jovens do sexo feminino com massa pélvica suspeita.
    [Show full text]
  • Adenosarcoma of Uterus with Sarcomatous Overgrowth and Rhabdomyoblastic Differentiation - a Rare Pathological Entity
    https://www.scientificarchives.com/journal/journal-of-experimental-pathology Journal of Experimental Pathology Case Report Adenosarcoma of Uterus with Sarcomatous Overgrowth and Rhabdomyoblastic Differentiation - A Rare Pathological Entity Gaurav Sharma1, Prachi* 1Senior Consultant, Dharamshila Narayana superspeciality hospital, New Delhi- 110096 2Senior resident, Dharamshila Narayana superspeciality hospital, New Delhi- 110096 *Correspondence should be addressed to Prachi; [email protected] Received date: December 10, 2020, Accepted date: January 18, 2021 Copyright: © 2021 Sharma G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Adenosarcoma is a rare tumor composed of benign glandular epithelium and a malignant mesenchymal component. Here we present a case of 62-year-old female, with irregular post-menopausal bleeding. On histological diagnosis, Uterine adenosarcoma with rhabdomyoblastic differentiation with sarcomatous overgrowth was made, which carries poor prognosis and reduces the survival period of a patient. Her post – operative course was uneventful. Keywords: Adenosarcoma, Rhabdomyoblastic, Sarcomatous overgrowth Introduction expression. The sarcomatous component stains for CD10 which may be lost in the cases of sarcomatous overgrowth Uterine adenosarcoma is a rare malignancy. It is defined variants. The rate of recurrence for adenosarcoma without as a biphasic tumor composed of both sarcomatous stroma sarcomatous overgrowth is between 15 & 25% and with and benign epithelial components. When the sarcomatous sarcomatous overgrowth is as high as 45-70%. Distant component occupies more than 25 % of the tumor then metastases have been described in about 5% of affected it is referred to as the sarcomatous overgrowth which patients [1].
    [Show full text]
  • Mullerian Adenosarcoma of the Endometrium in a 19-Year-Old Girl: Case Report and a Literature Review
    Open Access Austin Critical Care Case Reports Case Report Mullerian Adenosarcoma of the Endometrium in a 19-Year-Old Girl: Case Report and a Literature Review Miyoshi A1, Ueda Y1*, Sato K2 and Kimura T1 1Department of Obstetrics and Gynecology, Osaka Abstract University Graduate School of Medicine, Japan Mullerian adenosarcoma of the endometrium in adolescent girls is extremely 2Department of Pathology, Osaka University Graduate rare, with only fifteen cases under 20 years old having been reported to date. School of Medicine, Japan We describe here a new case of adolescent Mullerian adenosarcoma and *Corresponding author: Yutaka Ueda, Department of provide an updated review of the previous literature on such rare tumors. Our Obstetrics and Gynecology, Osaka University Graduate 19-year-old case presented with a six-month history of prolonged menstruation. School of Medicine, 2-2, Yamadaoka Suita, Osaka 567- She had not yet had any sexual relationship. On gross examination, a fragile 0871, Japan mass was seen in her vagina that bled easily. A 4.0×2.0 cm mass was visualized with Magnetic Resonance Imaging (MRI). The tumor seemed to Received: January 05, 2020; Accepted: February 05, slightly invade the myometrium of the uterine corpus. Transvaginal ultrasound 2021; Published: February 12, 2021 sonography confirmed the presence of a 4.0 cm mass located in the cervix and vagina. The tumor biopsy was diagnosed as a Mullerian adenosarcoma of the endometrium. We performed a Total Abdominal Hysterectomy (TAH) and Bilateral Salpingectomy (BS). The post-surgical specimen was diagnosed as a pT1aNXM0 Mullerian adenosarcoma of the endometrium. The patient did not require adjuvant chemotherapy.
    [Show full text]
  • Retroperitoneal Low Grade Endometrial Stromal Sarcoma With
    Annals of Diagnostic Pathology 39 (2019) 25–29 Contents lists available at ScienceDirect Annals of Diagnostic Pathology journal homepage: www.elsevier.com/locate/anndiagpath Cytological-Pathologic Correlation Retroperitoneal low grade endometrial stromal sarcoma with florid T endometrioid glandular differentiation: Cytologic-histologic correlation and differential diagnosis ⁎ Amrou Abdelkader, Tamara Giorgadze Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA ARTICLE INFO ABSTRACT Keywords: Low grade endometrial stromal sarcoma (LGESS) is a rare neoplasm that typically arises in the uterine corpus Endometrial Stromal Sarcoma and accounts for less than 1% of uterine sarcomas. Infrequently, extra-uterine LGESS can occur. Histologically, Uterine Sarcoma LGESS is characterized by a monotonous population of cells that resemble the proliferative phase of endometrial Retroperitoneum stroma and in their classic form they exhibit tongue-like growth pattern of infiltration and/or lymphovascular Extrauterine invasion. Infrequently LGESS can demonstrate various morphologic differentiation patterns, including en- Glandular Differentiation dometrioid-type glands. We report the first fine needle aspiration (FNA) case of a periduodenal mass thatwas incidentally discovered on Computed Tomography (CT) scan of a 60-year-old female. The cytomorphologic and histologic findings and the immunohistochemical staining were consistent with a LGESS with endometrioid glandular differentiation. We are presenting the correlation between the cytologic, radiologic and pathologic features. 1. Introduction osteoarthritis, diabetes type II and bilateral cataracts. The patient is thought to have a urinary tract infection, pyelonephritis or a kidney Glandular differentiation in low grade endometrial stromal sarcoma stone. She was prescribed analgesics and was transferred to the emer- (LGESS) is not common. There are only a few cases that have been gency department where a CT scan was ordered to check for possible described in the literature.
    [Show full text]
  • Sarcoma of the Uterus. Guideline of the DGGG (S2k-Level, AWMF Registry No
    1028 GebFra Science Sarcoma of the Uterus. Guideline of the DGGG (S2k-Level, AWMF Registry No. 015/074, August 2015) Uterine Sarkome. Leitlinie der DGGG (S2k-Level, AWMF-Registernummer 015/074, August 2015) Authors D. Denschlag 1, F. C. Thiel 2, S. Ackermann3,P.Harter4, I. Juhasz-Boess 5, P. Mallmann 6, H.-G. Strauss7, U. Ulrich8, L.-C. Horn9, D. Schmidt 10, D. Vordermark 11, T. Vogl12, P. Reichardt13,P.Gaß14, M. Gebhardt 15, M. W. Beckmann 14 Affiliations The affiliations are listed at the end of the article. Key words Abstract Zusammenfassung l" uterine sarcoma ! ! l" guideline Purpose: Official guideline published and coordi- Ziel: Offizielle Leitlinie, publiziert und koordiniert l" leiomyosarcoma nated by the German Society of Gynecology and von der Deutschen Gesellschaft für Gynäkologie l" endometrial Obstetrics (DGGG). Due to their rarity and their und Geburtshilfe (DGGG). Aufgrund ihrer Selten- stromal sarcoma l" carcinosarcoma heterogeneous histopathology uterine sarcomas heit und heterogenen Histopathologie stellen ute- remain challenging tumors to manage and need rine Sarkome eine Herausforderung bzgl. des kli- Schlüsselwörter a multidisciplinary approach. To our knowledge nischen Managements dar und bedürfen von da- l" uterine Sarkome so far there is no evidence-based guideline on her einem multidisziplinären Ansatz. Nach unse- l" Leitlinie the appropiate management of these heteroge- rem Kenntnisstand existieren bis dato keine ver- l" Leiomyosarkom l" endometriale neous tumors. bindlichen, evidenzbasierten Empfehlungen bzgl. Stromasarkome Methods: This S2k-guideline is the work of an des angemessenen Managements dieser hetero- l" Karzinosarkom representative committee of experts from a varie- genen Tumore. ty of different professions who were commis- Methoden: Die vorliegende S2k-Leitlinie ist das sioned by the DGGG to carry out a systematic lit- Ergebnis der Arbeit eines repräsentativen inter- erature review of uterine sarcoma.
    [Show full text]
  • Uterine Adenosarcoma with Omentum Metastasis Complicated by a Rapidly Progressing Liver Abscess
    Taiwanese Journal of Obstetrics & Gynecology 54 (2015) 332e335 Contents lists available at ScienceDirect Taiwanese Journal of Obstetrics & Gynecology journal homepage: www.tjog-online.com Research Letter Uterine adenosarcoma with omentum metastasis complicated by a rapidly progressing liver abscess Hsuan-Chih Tsai a, Hsin-Yuan Lin b, Hsin-Wang Lin c, Chun-Wen Chen d, To-An Chen e, * Kuang-Hua Chen c, a Division of Family Medicine, National Defense Medical Center, Taichung Armed Force General Hospital, Taichung, Taiwan b Division of General Surgery, National Defense Medical Center, Taichung Armed Force General Hospital, Taichung, Taiwan c Division of Obstetrics and Gynecology, National Defense Medical Center, Taichung Armed Force General Hospital, Taichung, Taiwan d Division of Radiology, National Defense Medical Center, Central Taiwan University of Science and Technology, Taichung Armed Force General Hospital, Taichung, Taiwan e Division of Pathology, National Defense Medical Center, Taichung Armed Force General Hospital, Taichung, Taiwan article info Article history: A 64-year-old married female, gravid 2, parity 2, menopaused at Accepted 21 April 2014 age 59 years. She presented to our emergency department with complaints of general malaise, abdominal pain, and heavy vaginal bleeding for 1 week. She had a history of poorly controlled type 2 diabetes mellitus (DM) and hypertensive cardiovascular disease for 2 years. After a physical examination, vital signs were uneventful, except she was febrile with a temperature of >39.8 Celsius. A large, Uterine sarcomas are a rare form of uterine malignancy that arise soft, movable mass (~10 cm in length) occupied the lower from uterine mesenchymal elements (i.e., smooth muscle and con- abdomen.
    [Show full text]
  • Article Download
    wjpls, 2021, Vol. 7, Issue 6, 184-186 Case Study ISSN 2454-2229 Jihad et al. World Journal of Pharmaceutical World Journal and Life of Pharmaceutical Sciences and Life Science WJPLS www.wjpls.org SJIF Impact Factor: 6.129 UTERINE ADENOSARCOMA (INDIVIDUAL CASE STUDY) *1El Koummi Jihad, 2Youssouf Nabila, 3Mokhlis Sabah, 4Benhessou Mustapha, 5Ennachit Mohamed, 6ElKarroumi Mohamed 1,2,3Resident in Gynecology Obstetric, CHU IBN Rochd Casablanca Morocco. 4,5,6Professor of Gynecology Obstetric, CHU IBN Rochd Casablanca Morocco. Corresponding Author: El Koummi Jihad Resident in Gynecology Obstetric, CHU IBN Rochd Casablanca Morocco. Article Received on 21/03/2021 Article Revised on 11/04/2021 Article Accepted on 31/05/2021 ABSTRACT Uterine adenosarcoma is an extremely rare tumor (8% of uterine sarcomas), characterized by a proliferation, malignant mesenchymal and benign epithelial. It is recognized by its difficult diagnostic and therapeutic management. Its prognosis is relatively favorable. The objective of this study is to report the clinical aspects and the therapeutic modalities of a case of uterine adenosarcoma revealed by postmenopausal metrorrhagia in a 63- year-old patient, treated for luberkunian adenocarcinoma of the colon. Examination of the patient revealed a polyploid formation delivered through the uterine cervix. Biopsy curettage of the endometrium revealed the presence of a uterine adenosarcoma. Pelvic MRI showed a uterine lesion process infiltrating the myometrium by more than 50%. The treatment was essentially surgical. KEYWORDS: Adenosarcoma, Uterus, Hysterectomy. INTRODUCTION proliferation compatible with endometrial adenosarcoma. Pelvic MRI showed 13 mm inhomogeneous thickness of The term adenosarcoma, first described in 1974 by the endometrium, in T1 inhomogeneous hyposignal, T2 Clement and Sully, refers to a tumor of biphasic nature, inhomogeneous hypersignal, poorly enhanced after associating a benign glandular and malignant gadolinium injection, with infiltration of the sarcomatous contingent.[1] anterofundial wall over 50% (picture 1, 2).
    [Show full text]
  • Proforma for Histopathology Reporting
    Uterine Malignant and Potentially Malignant Mesenchymal Tumours Histopathology Reporting Guide Family/Last name Date of birth DD – MM – YYYY Given name(s) Patient identifiers Date of request Accession/Laboratory number DD – MM – YYYY Elements in black text are CORE. Elements in grey text are NON-CORE. SCOPE OF THIS DATASET indicates multi-select values indicates single select values CLINICAL INFORMATION (select all that apply) (Note 1) ACCOMPANYING SPECIMENS (select all that apply) (Note 4) Information not provided None submitted History of previous cancer, specify Peritoneal biopsies, specify site(s) Ovaries Left Right Not specified History of previous gynecologic biopsy/surgical excision, Fallopian tubes specify Left Right Not specified Omentum Lymph nodes, specify site(s) Other, specify Other, specify OPERATIVE PROCEDURE (select all that apply) (Note 2) TUMOUR SITE (select all that apply) (Note 5) Not specified Hysterectomy Indeterminate Simple total Cervix Simple supracervical/subtotal Lower uterine segment Radical Corpus Type not specified Other, specify Myomectomy Lymph nodes, specify site(s) Other, specify MAXIMUM TUMOUR DIMENSION (Note 6) mm Cannot be assessed, specify SPECIMEN INTEGRITY (Note 3) Intact Non-intact Morcellated/fragmented BLOCK IDENTIFICATION KEY (Note 7) Opened (List overleaf or separately with an indication of the nature and origin of all tissue blocks) DRAFT Version 1.0 Published XXXX 2021 ISBN: XXXX Page 1 of 4 © 2021 International Collaboration on Cancer Reporting Limited (ICCR). Uterine Malignant and Potentially
    [Show full text]
  • Imaging Description of Extragenital Müllerian Adenosarcoma: a Case Report Descrição Da Imagem Do Adenosarcoma Mülleriano Extragenital: Relato De Caso
    THIEME 124 Case Report Imaging Description of Extragenital Müllerian Adenosarcoma: A Case Report Descrição da imagem do adenosarcoma mülleriano extragenital: relato de caso Annalisa Mone1 Piergiorgio Iannone2 1 Department of Radiology, University of Verona, Verona, Italy Address for correspondence Annalisa Mone, MD, Reparto di 2 Section of Obstetrics and Gynecology, Department of Morphology, Radiologia, Policlinico G.B. Rossi, Università Degli Studi di Verona, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy Piazzale LA Scuro, 10, 37134, Verona, Italy (e-mail: [email protected]). Rev Bras Ginecol Obstet 2019;41:124–128. Abstract Müllerian adenosarcoma is a very rare gynecological disease, comprising 5% of uterine sarcomas. Extragenital localizations are even rarer. We report a very interesting case of Keywords a 27-year-old woman complaining of pelvic pain, with a subsequent diagnosis of ► extragenital müllerian extragenital Müllerian adenosarcoma. This is the first case reported in the literature adenosarcoma with a complete and wide imaging description. Even if rare, Müllerian adenosarcoma ► computed should be hypothesized in case of young female patients presenting with suspicious tomography pelvic mass. ► pelvic mass ► uterine sarcoma Resumo O adenosarcoma Mülleriano é uma doença ginecológica muito rara, compreendendo 5% dos sarcomas uterinos. Localizações extragenitais são ainda mais raras. Relatamos Palavras-chave um caso muito interessante de uma mulher de 27 anos queixando-se de dor pélvica ► adenosarcoma com diagnóstico subsequente de adenosarcoma Mülleriano extragenital. Este é o mülleriano primeiro caso relatado na literatura com uma descrição completa e ampla de imagem. extragenital Mesmo que raro, o adenosarcoma Mülleriano deve ser hipotetizado no caso de ► fi tomogra a pacientes jovens do sexo feminino com massa pélvica suspeita.
    [Show full text]
  • Endometrial Adenosarcoma: Case Report
    Case Report Annals of Clinical Case Reports Published: 31 Oct, 2016 Endometrial Adenosarcoma: Case Report Mustafa Kandaz1*, Elanur Karaman2, Ozan Cem Güler1, Sevdegül Mungan3 and Adnan Yöney1 1Department of Radiation Oncology, Karadeniz Technical University, Turkey 2Department of Medical Oncology, Karadeniz Technical University, Turkey 3Department of Pathology, Karadeniz Technical University, Turkey Abstract A 39 year old woman, who had 3 children, was admitted with complaints of abnormal uterine bleeding. Endometrial biopsy was performed and result was found as endometrial adenosarcoma. There were no distant metastases found at imaging. TAH + BSO (Total Abdominal Hysterectomy and Bilateral Salpingo-Oophorectomy) operation was performed and adjuvant chemotheraphy (four cyclus ifosfamide, mesna, epirubicin) was given. We did not encounter any problems in monitoring. This case which includes endometrial adenosarcoma is presented because of its rarity. Keywords: Endometrial adenosarcoma; Malignant mixed mullerian tumor; Vaginal bleeding; Computer tomography Introduction The uterine Müllerian adenosarcoma, a mixed mesodermal tumor variant, is described by a glandular proliferation without a typical in a maligne sarcomatous stroma [1]. The endometrial adenosarcoma is a kind of rare endometrial cancer, even if endometrial adenosarcoma is often seen in premenapausal and postmenapausal women. It contains the epithelial benign and malignant stromal component. The case is presented due to a rare tumor. It consists of 8% of uterine sarcomas [2,3]. With monitored in endometrium, it can be seen in localisations such as cervix, fallopian tube, ovarian and paraovarian tissues [3]. İt presents as a protuberant polypoid mass in to the cervical channel [4]. Generally, clinical manifestations are non-specific ones, usually common to those of other neoplasias having that localization.
    [Show full text]
  • Uterine Adenosarcoma: a Case-Based Review of the Diagnostic Features
    This is a repository copy of Uterine adenosarcoma: a case-based review of the diagnostic features. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/126128/ Version: Accepted Version Article: Allen, KE, Bennett, PA and Orsi, NM (2018) Uterine adenosarcoma: a case-based review of the diagnostic features. Diagnostic Histopathology, 24 (1). pp. 45-47. ISSN 1756-2317 https://doi.org/10.1016/j.mpdhp.2017.12.001 © 2017, Published by Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/). Reuse This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) licence. This licence only allows you to download this work and share it with others as long as you credit the authors, but you can’t change the article in any way or use it commercially. More information and the full terms of the licence here: https://creativecommons.org/licenses/ Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing [email protected] including the URL of the record and the reason for the withdrawal request. [email protected] https://eprints.whiterose.ac.uk/ Uterine adenosarcoma: a case-based review of the diagnostic features Katie E. Allen1,*, MBChB, Specialty Registrar, Paul A. Bennett2, BMedSci (Hons), BMBS, Consultant, Nicolas M. Orsi1,3, BSc (Hons), MBChB, PhD, Clinical Lecturer. 1Department of Histopathology, Level 5, Bexley Wing, St James's University Hospital, Beckett Street, Leeds LS9 7TF.
    [Show full text]
  • A Practical Approach to the Diagnosis of Mixed Epithelial and Mesenchymal Tumours of the Uterus W Glenn Mccluggage
    Modern Pathology (2016) 29, S78–S91 S78 © 2016 USCAP, Inc All rights reserved 0893-3952/16 $32.00 A practical approach to the diagnosis of mixed epithelial and mesenchymal tumours of the uterus W Glenn McCluggage Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK The current 2014 World Health Organization (WHO) Classification of mixed epithelial and mesenchymal tumours of the uterus includes categories of carcinosarcoma, adenosarcoma, adenofibroma, adenomyoma and atypical polypoid adenomyoma, the last two lesions being composed of an admixture of benign epithelial and mesenchymal elements with a prominent smooth muscle component. In this review, each of these categories of uterine neoplasm is covered with an emphasis on practical tips for the surgical pathologist and new developments. In particular, helpful clues in the distinction between carcinosarcoma and dedifferentiated endometrial carcinoma will be discussed. In addition, salient features to help distinguish between adenofibroma, adenosarcoma, embryonal rhabdomyosarcoma and other mesenchymal neoplasms in the differential diagnosis will be outlined. Finally, a discussion of adenomyoma and its main differential diagnostic considerations will be covered. Modern Pathology (2016) 29, S78–S91; doi:10.1038/modpathol.2015.137 Mixed epithelial and mesenchymal tumours of the Uterine carcinosarcoma uterus comprise a heterogenous group of neoplasms with categories of carcinosarcoma, adenosarcoma, Clinical Features adenofibroma, adenomyoma and atypical polypoid Uterine carcinosarcoma (malignant Mixed Mullerian adenomyoma included in the current 2014 World tumour) is an uncommon uterine tumour1 that 1 Health Organization (WHO) Classification. In the accounts for less than 5% of uterine malignancies prior WHO (2003), the category of carcinofibroma and typically occurs in elderly women.
    [Show full text]