ToxExpoTM Directory

54th Annual Meeting & ToxExpoTM March 22–26, 2015 San Diego Convention Center San Diego, California TRANSLATING DISCOVERIES

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every step of the way. www.criver.com/SOT2015 ToxExpo Directory

Table of Contents ToxExpo Exhibit Hall Hours Supporters...... 2 Monday, March 23 9:00 AM–4:30 PM Exhibit Hall Map ...... 4 2015 Exhibitors...... 6 Tuesday, March 24 8:30 AM–4:30 PM General Information...... 10 Wednesday, March 25 8:30 AM–4:30 PM Exhibitor-Hosted Sessions...... 14 Exhibitor Descriptions ...... 22 Exhibitor Product/Service Category Listing ...... 136

Follow us on Twitter at @ToxExpo and @SOToxicology

Recording, Photography, and Cell Phone Policy SOT Badge Policy—altering of SOT badges in any way is strictly prohibited. All attendees must be officially registered • Photographing exhibit booths is prohibited. for the meeting. Anyone with an altered badge will be asked • Electronic capture of scientific sessions by any method by security to visit the SOT Registration Desk to verify their is prohibited. credentials.

• All cell phones and electronic devices must be put on

nd UND Noncontracted Exhibit Space a E mute while attending scientific sessions. 5 R 1 Persons, companies, or organizations that have not contracted • Children under the age of 15 and guest/spouse with SOT to occupy space in the Exhibit Hall will not be attendees will not be allowed in the Exhibit Hall. permitted to display or demonstrate products, processes or services, solicit orders, or distribute advertising materials in The policies adopted above will be enforced by the Society. Those the convention center, parking lots or in any hotel contracted individuals who do not comply will be asked to leave the session or by SOT. Solicitation beyond an exhibitor’s booth, or by ToxExpo floor. If you have any questions regarding these policies, anyone other than approved exhibitors, is strictly prohibited. please contact the SOT Headquarters Office.

The purpose of the Society of Toxicology's exhibit program (ToxExpo) is to further the education of scientists working in the field of Toxicology and to support the mission of the Society. Exhibits are required to be educational in character and relevant to the science of Toxicology.

This directory, its contents, and graphics are ©2015 by the Society of Toxicology as proprietary products of SOT. All rights are reserved. The content of this directory may not, in whole or in part, be reproduced, copied, disseminated, entered into a computer database, or otherwise utilized, in any form or manner or by any means except for the user’s individual, personal, and confidential reference. No text or graphics may be copied or used without written permission from the Society of Toxicology. For further information, please contact SOT Headquarters.

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Follow us on Twitter at @SOToxicology and @ToxExpo 1 For up-to-date information use Tweet using #2015SOT and #toxexpo the SOT Mobile Event App or the Online Planner The Society of Toxicology appreciates the generous contributions of the 54th Annual Meeting Supporters: (Supporter listing as of February 12, 2015) Platinum Gold ($5,000–9,999) ($2,500–4,999) AbbVie The Allergan Foundation Amgen, Inc. Burroughs Wellcome Fund DuPont Haskell Global Centers for Health and AstraZeneca Environmental Sciences Boehringer Ingelheim Pharmaceuticals, Inc. Eastman Charitable Foundation GlaxoSmithKline EUROTOX 2015 Merck & Co., Inc. ExxonMobil Biomedical Sciences, Inc. Genentech MPI Research Gilead Sciences, Inc. Takeda Gradient ToxServices LLC Hamner Institutes for Health Sciences US Food and Drug Administration Toxicology Excellence for Risk Assessment (TERA) Silver ($2,000–2,499) Contributor ($1,000–1,999) Academy of Toxicological Sciences (ATS) Datacolor Inc. Agilent Eisai, Inc. American College of Toxicology (ACT) IDEXX Laboratories, Inc. Calvert Labs WIL Research The Coca-Cola Company Elliot Gordon Consulting, LLC Environmental Mutagenesis and Genomics Society (EMGS) Human Toxicology Project Consortium (HTPC) MRIGlobal NSF International Safety Pharmacology Society (SPS) Smithers Avanza Toxicology Services Society of Toxicologic Pathology (STP) SRI International Teratology Society (TS)

Products and Services 365 days of the year—Visit ToxExpo.com 2 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo ♦ 2015 Annual Meeting and ToxExpo Diamond ($10,000 or more) American Chemistry Council Bristol-Myers Squibb Company Colgate-Palmolive Company National Institute of General Medical Sciences of the National Institutes of Health Novartis Institutes for BioMedical Research Roche, Inc. Sanofi Syngenta

Diamond Level Supporter Exhibitors Drawings to take place on Monday, Tuesday, and Wednesday in the ToxExpo. $500 American Express Gift Card awarded each day. Drop your business cards in the ToxExpo prize drawing boxes found in all Diamond Level Exhibitor Supporter booths, see t on map.

♦ Battelle 1727 ♦ Charles River 1326 ♦ National Institute of Environmental Health Sciences (NIEH) 2228 ♦ Pfizer Worldwide Research and Development 1321 ♦ SOT Endowment Fund, Society of Toxicology 526 ♦ WuXi AppTec 1833

Follow us on Twitter at @SOToxicology and @ToxExpo 3 For up-to-date information use Tweet using #2015SOT and #toxexpo the SOT Mobile Event App or the Online Planner ToxExpo Floor Plan

EXHIBIT HALL EXHIBIT Exhibit Hall • Ground Level

Special Mention and Thanks to:

Badge Lanyards—CiToxLAB Escalator Clings—Enzo Life Sciences, MPI Research Hotel Room Key Cards—PreLabs Meeting Notepads—Battelle Attendee Bags—BioReliance Meeting Pens—ToxServices LLC Charging Stations—Datacolor Inc., IDEXX Laboratories, Inc., Research Diets

Concession Concession Mobile Charging Station Stand Stand Mobile Charging Station

RC/SIG/SS Poster Boards POSTER BOARDS 400s POSTER BOARDS 300s

High School Poster Exposition 545 644 745 844 945 1044 1045 1145 1244 1345 1444 1545 1644 1844 1845 1944 1945 2044 2145 2244 643 1142 1743 543 642 743 842 943 1042 1043 1143 1242 1343 1442 1543 1642 1842 1843 1942 1943 2042 2143 2242 2243 2342 Exhibitor 741 840 941 1040 1141 1240 1341 1440 1541 1640 1841 1940 1941 2040 2141 2240 2241 2340 Service Center 539 638 639 738 739 838 939 1038 1039 1138 1838 1839 1938 1939 2038 2139 2238 2239 2338 1737 Poster 537 636 637 736 737 836 837 936 1037 1136 1236 1637 1736 2037 2136 2237 2336 Pick Up Desk 1135 Charles 1535 1634 1834 635 734 835 934 935 1035 1134 1234 1635 1734 2035 2134 1032 River 1733 1833 1933 2133 633 732 733 832 933 1133 1232 1633 1732 1832 ♦ 2233 2332 ToxExpo Global Gallery SOT Pavilion 1326 2016 of Toxicology 731 830 831 930 931 1031 1130 1531 1630 2031 2231 2330 Sales O ce POSTER 526 1028 2128 629 729 828 929 1029 2028 2029 2129 2228 ♦ 2229 2328 2327 POSTER BOARDS 726 827 928 1126 1127 1527 1626 1627 1727 1827 1927 ToxExpo Show ♦ 627 727 826 927 1026 1027 ♦ ♦ 2026 2027 2126 2127 2226 2227 2326 BOARDS Management 500s O c e 200s

321 420 421 520 521 620 621 721 820 821 1121 1321 1420 1720 1820 1921 2020 2021 2120 2121 2220 718 918 919 1018 1019 Huntingdon 1619 1719 1819 1918 2219 2318 2319 319 418 419 518 519 618 619 719 818 819 1216 1215 1319 1418 Harlan 1718 1818 1919 2018 2019 2118 2119 2218 1117 1515 317 416 417 516 617 716 817 916 1617 1716 1717 1816 1917 2016 2017 2116 2217 2316 715 814 AISLE 300 AISLE 400 AISLE 500 515 614 AISLE 600 AISLE 700 AISLE 800 AISLE 900 915 1015 1114 1715 1814 1915 2014 2115 2214 1012 AISLE 1000 AISLE 1100 AISLE 1200 AISLE 1300 1313 AISLE 1400 AISLE 1500 AISLE 1600 AISLE 1700 AISLE 1800 AISLE 1900 AISLE 2000 AISLE 2100 AISLE 2200 AISLE 2300 AISLE 2400 313 513 612 613 712 913 1013 1112 1113 1212 2113 2212 2213 2312 311 408 511 610 611 710 1011 1111 1210 1810 1911 2111 2210 2211 709 1108 1509 1608 1709 MPI 2008 309 509 608 609 708 809 909 1008 1009 1109 1208 1309 Research 1909 906 1406 1806 807 907 1006 1107 1206 1207 1306 1307 1707 Covance 1801 1005 1205 1304 1305 1404 Inc. 1102 1602 1601 POSTER BOARDS 600s 903 1002 1003 1103 1303 1402 1501 1703 1802 POSTER BOARDS 100s 801 900 1200 1201 1300 Poster Retrieval Table 901 1000 1001 1100 1101 1301 1400 1600 1701 1800 Poster RetrievalvTable Scientific Poster Maps: ToxExpoToxExpo Entrance Entrance Detailed Poster Maps can be found in the Program on pages 121–128. Products and Services 365 days of the year—Visit ToxExpo.com 4 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo Diamond Level Supporter Prize Drawing Win $500!

Drawings to take place on Monday, Tuesday, and Wednesday in the ToxExpo. $500 American Express Gift Card awarded each day. Drop your business cards in the ToxExpo prize drawing boxes found in all Diamond Level

Exhibitor Supporter booths, see t on map. EXHIBIT HALL Booth Page ♦ Battelle 1727 36 ♦ Charles River 1326 45 ♦ National Institute of Environmental Health Sciences (NIEHS) 2228 92 ♦ Pfi zer Worldwide Research and Development 1321 99 ♦ SOT Endowment Fund, Society of Toxicology 526 115 ♦ WuXi AppTec 1833 133

Concession Concession Mobile Charging Station Stand Stand Mobile Charging Station

RC/SIG/SS Poster Boards POSTER BOARDS 400s POSTER BOARDS 300s

High School Poster Exposition 545 644 745 844 945 1044 1045 1145 1244 1345 1444 1545 1644 1844 1845 1944 1945 2044 2145 2244 643 1142 1743 543 642 743 842 943 1042 1043 1143 1242 1343 1442 1543 1642 1842 1843 1942 1943 2042 2143 2242 2243 2342 Exhibitor 741 840 941 1040 1141 1240 1341 1440 1541 1640 1841 1940 1941 2040 2141 2240 2241 2340 Service Center 539 638 639 738 739 838 939 1038 1039 1138 1838 1839 1938 1939 2038 2139 2238 2239 2338 1737 Poster 537 636 637 736 737 836 837 936 1037 1136 1236 1637 1736 2037 2136 2237 2336 Pick Up Desk 1135 Charles 1535 1634 1834 635 734 835 934 935 1035 1134 1234 1635 1734 2035 2134 1032 River 1733 1833 1933 2133 633 732 733 832 933 1133 1232 1633 1732 1832 ♦ 2233 2332 ToxExpo Global Gallery SOT Pavilion 1326 2016 of Toxicology 731 830 831 930 931 1031 1130 1531 1630 2031 2231 2330 Sales O ce POSTER 526 1028 2128 629 729 828 929 1029 2028 2029 2129 2228 ♦ 2229 2328 2327 POSTER BOARDS 726 827 928 1126 1127 1527 1626 1627 1727 1827 1927 ToxExpo Show ♦ 627 727 826 927 1026 1027 ♦ ♦ 2026 2027 2126 2127 2226 2227 2326 BOARDS Management 500s O c e 200s

321 420 421 520 521 620 621 721 820 821 1121 1321 1420 1720 1820 1921 2020 2021 2120 2121 2220 718 918 919 1018 1019 Huntingdon 1619 1719 1819 1918 2219 2318 2319 319 418 419 518 519 618 619 719 818 819 1216 1215 1319 1418 Harlan 1718 1818 1919 2018 2019 2118 2119 2218 1117 1515 317 416 417 516 617 716 817 916 1617 1716 1717 1816 1917 2016 2017 2116 2217 2316 715 814 AISLE 300 AISLE 400 AISLE 500 515 614 AISLE 600 AISLE 700 AISLE 800 AISLE 900 915 1015 1114 1715 1814 1915 2014 2115 2214 1012 AISLE 1000 AISLE 1100 AISLE 1200 AISLE 1300 1313 AISLE 1400 AISLE 1500 AISLE 1600 AISLE 1700 AISLE 1800 AISLE 1900 AISLE 2000 AISLE 2100 AISLE 2200 AISLE 2300 AISLE 2400 313 513 612 613 712 913 1013 1112 1113 1212 2113 2212 2213 2312 311 408 511 610 611 710 1011 1111 1210 1810 1911 2111 2210 2211 709 1108 1509 1608 1709 MPI 2008 309 509 608 609 708 809 909 1008 1009 1109 1208 1309 Research 1909 906 1406 1806 807 907 1006 1107 1206 1207 1306 1307 1707 Covance 1801 1005 1205 1304 1305 1404 Inc. 1102 1602 1601 POSTER BOARDS 600s 903 1002 1003 1103 1303 1402 1501 1703 1802 POSTER BOARDS 100s 801 900 1200 1201 1300 Poster Retrieval Table 901 1000 1001 1100 1101 1301 1400 1600 1701 1800 Poster RetrievalvTable ToxExpoToxExpo Entrance Entrance

Follow us on Twitter at @SOToxicology and @ToxExpo 5 For up-to-date information use Tweet using #2015SOT and #toxexpo the SOT Mobile Event App or the Online Planner 2015 EXHIBITORS

(As of Febuary 12, 2015) Please use the SOT Mobile Event Aßpp or visit www.ToxExpo.com for the most current information on products and services.

♦ 2015 Annual Meeting Diamond Level Exhibitor Supporters. ♦ SOT Pavilion...... 526 ★ 2015 Annual Meeting Supporters are indicated by the star. • Endowment Opportunities ▲ SOT Affiliates are indicated by a triangle. • Member Services, RC, SIG, and SS Activities • Outreach Information Companies that have been ToxExpo Exhibitors • Toxicological Sciences for 25 years or more are in bold.

Company Name Booth # Company Name Booth # Biopredic International...... 608 A Begins on page 22. Biopta Ltd...... 1234 ABC Laboratories...... 1236 BioreclamationIVT...... 1300 BioReliance...... 1313 2015 EXHIBITORS Absorption Systems...... 309 Accelera S.r.l...... 2220 Biosearch Technologies, Inc...... 2119 ACEA Biosciences, Inc...... 906 BioSpyder Technologies...... 2233 ACGIH®...... 610 BioStat Consultants, Inc...... 927 Advinus Therapeutics Limited...... 2121 BioTox Sciences...... 1709 AEgis Technologies Group...... 1000 BMG LABTECH ...... 1944 Agena Bioscience...... 939 Bruker...... 1042 AI BioTech, LLC...... 1003 BSL BIOSERVICE Scientific Laboratories GmbH...... 837 Alabama Research & Development...... 1541 C Begins on page 40. ALCEDIAG...... 635 ★ Calvert Laboratories, Inc...... 918 Alconox, Inc...... 1630 Cardno ChemRisk & Cardno...... 627 Algorithme Pharma...... 1141 CARE Research LLC/Colorado Histo-Prep...... 721 Alliance Pharma...... 1207 Carter2 Systems, Inc...... 2118 Alpha Genesis, Inc. (AGI)...... 900 Cayman Chemical...... 1001 Alpha MED Scientific Inc...... 2211 CBSET, Inc...... 809 Alturas Analytics, Inc...... 1802 CDC NCEH/ATSDR...... 1843 American Board of Toxicology (ABT)...... 1307 Cedarlane...... 1031 ★ American College of Toxicology (ACT)...... 736 CellSystems GmbH...... 1845 American College of Veterinary Ophthalmologists...... 2141 Cellular Dynamics International, Inc...... 801 American Preclinical Services...... 1933 Center for Drug Safety Evaluation and Research...... 2134 American Screening...... 2113 Certara...... 1945 Americans for Medical Progress...... 511 CH Technologies (USA), Inc...... 1440 Ani Lytics, Inc...... 1720 ChanTest Corp...... 901 Antech Diagnostics GLP...... 1304 ♦ ▲ Charles River...... 1326 Applied BioPhysics, Inc...... 1005 Chemical Solutions Ltd...... 1718 Aptuit LLC...... 719 Chilworth Technology Ltd...... 1734 Aquaneering, Inc...... 1842 CITI Program at University of Miami...... 734 Arbor Assays...... 2145 CiToxLAB...... 2327 ArunA Biomedical, Inc...... 2237 ClearH2O, Inc...... 1043 Asterand Bioscience...... 1008 Clever Sys Inc...... 1138 Axiogenesis...... 903 Comparative Biosciences (CBI)...... 737 Axion Biosystems, Inc...... 817 CorDynamics...... 1206 B Begins on page 35. Cosmo Bio USA, Inc...... 831 BASF SE...... 2008 ▲ Covance Inc...... 1601 BASi (Bioanalytical Systems, Inc)...... 1200 CRC Press—Taylor & Francis Group LLC...... 1626 ♦ Battelle...... 1727 Critical Path Institute...... 743 BBD BIOPHENIX S.L. - BIOBIDE...... 313 CTEH®...... 1136 Bio Medic Data Systems, Inc...... 1501 CXR Biosciences Limited...... 1715 Bioculture (Mauritius) Ltd...... 1028 Cyprotex...... 1733 BioPorto Diagnostics A/S...... 907

Products and Services 365 days of the year—Visit ToxExpo.com 6 ♦ 2015 Diamond Sponsor | ✯ 2015 Sponsor 25 years or more Exhibitor are Bold | ▲ SOT Affiliates 2015 EXHIBITORS

Company Name Booth # Company Name Booth #

D Begins on page 52. ▲ Huntingdon Life Sciences/Harlan Laboratories...... 1515 Data Sciences International (DSI)...... 1918 Hμrel Corporation...... 2116 ★ Datacolor Inc...... 1816 Hurley Consulting Associates, Ltd...... 2328 Datamars, Inc...... 613 I Begins on page 70. Dermal Technology Laboratory Ltd...... 1637 ICDD-sas...... 731 Detroit R & D, Inc...... 821 ICF International...... 2128 DiaPharma Group, Inc...... 1938 ★ IDEXX Laboratories, Inc...... 1112 DiscoveRx...... 2316 IIT Research Institute (IITRI)...... 1719 DMT-USA Inc...... 521 ImQuest BioSciences...... 612 Douglas Connect GmbH...... 617 DV Biologics...... 1402 In Vitro ADMET Laboratories (IVAL)...... 1420 Dynex Technologies...... 931 INDIGO Biosciences, Inc...... 1006 Infinite Trading Inc...... 936 E Begins on page 55. InSphero Inc...... 2318 eBioscience, An Affymetrix Company...... 832 Instech Laboratories...... 1535 ECGVET, LLC...... 1100 Instem...... 1127 Ellegaard Göttingen Minipigs A/S...... 1012 Institute for In Vitro Sciences, Inc...... 1026 Elm Hill Breeding Labs, Inc...... 2027 Integrated Analytical Solutions, Inc...... 733 Elsevier...... 1406 Integrated Laboratory Systems, Inc. (ILS)...... 708 EMD Millipore Corporation...... 408 Integrated Nonclinical Development Solutions, Inc...... 1343 emka TECHNOLOGIES, INC...... 2018 IntelliCyt Corporation...... 807 EXHIBITORS 2015 Environ International Corp...... 1345 International Institute for the Advancement Environmental Health Perspectives (EHP)...... 2127, 2129 of Medicine...... 1820 Enzo Life Sciences...... 1045 Intertek...... 2115 EPISKIN...... 633 InvitroCue...... 2210 Epithelix...... 1244 Ionic Transport Assays, Inc...... 909 EPL Archives, Inc...... 1617 IPS Therapeutique...... 1134 EPL, Inc...... 1619 ITR Canada (Bozo & ITR Group)...... 1827 Eurofins Pharma Discovery Services...... 1319 IUTOX...... 537 ★ EUROTOX 2015...... 636 J Begins on page 78. Exemplar Genetics...... 1013 Jackson Laboratory, The...... 1107 Exiqon, Inc...... 317 Jai Research Foundation (JRF - America)...... 919 Experimur...... 1915 Japanese Society of Toxicology...... 539 Exponent, Inc...... 1306 ExPub (Expert Publishing)...... 1909 K Begins on page 79.

F Begins on page 64. KAER Biotherapeutics...... 1841 Kallistem...... 2332 FlowMetric...... 828 KCAS Bioanalytical Services...... 727 Fraunhofer ITEM...... 928 Kingfisher Biotech...... 930 G Begins on page 65. Korea Institute of Toxicology (KIT)...... 1117 Gene Tools LLC...... 2028 Kunming Biomed International (KBI)...... 1644 ★ ▲ Genentech...... 1032 L Begins on page 81. Genox Corporation...... 1210 Lab Products, Inc...... 1400 Gentronix, Limited...... 1130 LabLogic Systems, Ltd...... 1212 Gyros...... 1044 Lampire Biological Laboratories, Inc...... 1002 H Begins on page 66. Leadscope, Inc...... 716 H&T Corporation...... 2019 Leyden Group...... 1814 Hamilton Thorne...... 1232 Lhasa Limited...... 1635 HemoGenix Inc...... 1109 Litron Laboratories...... 1818 Hepregen Corporation...... 629 Lomir Biomedical, Inc...... 1819 Histo-Scientific Research Laboratories (HSRL)...... 1103 Lovelace Respiratory Research Institute (LRRI)...... 1602 HistoTox Labs, Inc...... 1716 Luxcel Biosciences, Ltd...... 2227 HTG Molecular Diagnostics...... 1208

♦ 2015 Diamond Sponsor | ✯ 2015 Sponsor 7 For up-to-date information use 25 years or more Exhibitor are Bold | ▲ SOT Affiliates the SOT Mobile Event App or the Online Planner 2015 EXHIBITORS

Company Name Booth # Company Name Booth #

M Begins on page 84. P Begins on page 98. Malvern Instruments...... 2213 Pacific BioLabs...... 820 Marken...... 2016 Partek Incorporated...... 1111 Marshall BioResources...... 1018 PDS Life Sciences...... 1634 Mary Ann Liebert, Inc...... 1040 Perceptive Instruments Ltd...... 1404 ♦ ▲ MatTek Corporation...... 620 Pfizer Worldwide Research and Development...... 1321 MB Research Laboratories...... 1145 Pharmaron...... 827 Medicilon Preclinical Research (Shanghai) LLC...... 1121 PhenoVista Biosciences...... 2120 Medicyte GmbH...... 1037 PhoenixBio Co., Ltd...... 311 Medline Industries, Inc...... 929 Phylonix Pharmaceuticals Inc...... 1800 Meso Scale Discovery...... 643 PointCross Life Sciences...... 1242 MetaSystems Group, Inc...... 513 Poly Scientific R&D Corp...... 321 2015 EXHIBITORS Mexican Society of Toxicology...... 638 Porsolt...... 915 Michelson Prize and Grants in Reproductive Biology...... 2240 Pre- Services, Inc. (PCRS)...... 1240 Microchip ID...... 1839 PreLabs...... 1707 Primate Products, Inc...... 745 MicroMatrices Associates Ltd...... 2017 Product Safety Labs...... 1701 Millar, Inc...... 1035 Promega Corp...... 2319 Mimetas...... 2212 Public Interest Incorporated Foundation Molecular Networks GmbH...... 1838 Biosafety Research Center (BSRC)...... 420 Moltox...... 1309 Purina LabDiet...... 1509 Mouse Specifics Inc...... 619 PWG Genetics...... 1102 ★ ▲ MPI Research...... 1801 ★ MRIGlobal...... 1543 Q Begins on page 104. Multi Channel Systems...... 830 QIAGEN Bioinformatics...... 1201 MultiCASE Inc...... 1133 QPS-THI...... 2029 N Begins on page 91. QTest Labs...... 1737 NAMSA...... 916 Qualyst Transporter Solutions...... 609 Nanion Technologies Inc...... 819 Quidel ...... 516 nanoComposix...... 1717 Quintiles...... 710 National Disease Research Interchange...... 842 Quotient Bioresearch...... 621 ♦ National Institute of Environmental R Begins on page 106. Health Sciences (NIEHS)...... 2228 ReachBio...... 2326 National Institute of Technology and Evaluation...... 2242 RegCheck ...... 2330 National Jewish Health...... 518 ReproCell...... 1143 National Library of Medicine...... 2126 Research Diets, Inc...... 1027 National Toxicology Program...... 2226 Reveal Biosciences...... 519 Nat’l Center for Toxicological Research...... 614 Ricerca Biosciences LLC ...... 738 Nature Publishing Group ...... 2218 Ridglan Farms, Inc...... 1303 NeuroScience Associates (NSA)...... 1444 RightAnswer.com...... 1011 Noveprim Group Ltd...... 943 Rockland Immunochemicals, Inc...... 2217 ★ NSF International/Health Sciences...... 1108 Royal Society of Chemistry, Cambridge...... 2143 Nucro-Technics Incorporated...... 1305 ▲ RTC, Research Toxicology Centre S.p.A...... 718 O Begins on page 96. RTI International...... 814 Oak Hill Genetics...... 934 S Begins on page 110. Omni International...... 933 SAGE Labs...... 618 ▲ Organovo...... 637 Sarstedt Inc...... 421 OtoScience Labs...... 729 Science/AAAS...... 1015 Otto Trading, Inc...... 2031 SCIREQ, Inc. (Scientific Respiratory Equipment)...... 2020 Oxford University Press...... 739 Seahorse Bioscience...... 520 ▲ Sequani Limited...... 1527 Seventh Wave...... 1341

Products and Services 365 days of the year—Visit ToxExpo.com 8 ♦ 2015 Diamond Sponsor | ✯ 2015 Sponsor 25 years or more Exhibitor are Bold | ▲ SOT Affiliates 2015 EXHIBITORS

Company Name Booth # Company Name Booth #

Shanghai InnoStar Biotech Co., Ltd (InnoStar)...... 1806 V Begins on page 127. Simulations Plus, Inc...... 2312 Veritox, Inc...... 1633 Sinclair Bio Resources...... 2035 Vet Path Services (VPS)...... 1832 Sinclair Research Center LLC...... 726 ★ Vimta Labs Limited...... 1939 Smithers...... 709 Vitrocell Systems GmbH...... 1442 SNBL USA SRC...... 712 Vitron, Inc...... 319 ▲ SNBL USA, Ltd...... 1215 Vivo Bio Tech Limited...... 935 SoBran Inc...... 1029 vivoPharm...... 1834 Society of Quality Assurance (SQA)...... 1940 Vivotecnia...... 835 SOLVO ...... 1732 VRL Laboratories...... 2219 Sony Corporation...... 509 Sophion Bioscience, Inc...... 1844 W Begins on page 130. Southern Research...... 1301 Wake Forest Innovations...... 941 Springer...... 715 WestChina-Frontier PharmaTech Co., Ltd. (WCFP)...... 1135 ★ SRI International...... 1126 ★ ▲ WIL Research...... 1019 STEMCELL Technologies Inc...... 1101 Wildlife International, a Division of EAG, Inc...... 1531 Stemina Biomarker Discovery, Inc...... 1919 World Precision Instruments...... 1114 Stillmeadow Inc...... 1418 Worldwide Clinical Trials...... 2026 Strand Life Sciences...... 642 Worldwide Primates, Inc...... 1205 Strategic Applications, Inc. (SAI)...... 1216 ♦ ▲ WuXi AppTec...... 1833 Suburban Surgical Company...... 1600 EXHIBITORS 2015 X Begins on page 133. Syngene International Limited...... 836 SynVivo...... 945 Xenometrics...... 1703 XenoTech, LLC...... 818 T Begins on page 120. XpressBio...... 2336 Taconic...... 1142 Xybion Medical Systems...... 1608 Takara Bio Europe AB ...... 1009 Y Begins on page 134. Tandem Labs...... 2014 Tecniplast USA, Inc...... 2044 Yecuris Corporation...... 913

That’s Nice...... 2037 Z Begins on page 13535. THINKY U.S.A., INC...... 2111 Zoologix, Inc...... 1642 Three S Japan Co., Ltd...... 2021 Zyleris PharmaTech...... 1917 Tianjin Institute of Pharmaceutical Research...... 826 TNO Triskelion...... 1921 TOXI-COOP Toxicological Research Center...... 1640 ★ ▲ Toxicology Excellence for Risk Assessment (TERA)...... 2231 Toxicology Regulatory Services (TRS)...... 1113 Toxicology Research Laboratory (TRL)...... 1545 Connect with ToxExpo Exhibitors via Toxikon Corporation...... 1627 the Mobile Event App! ToxPlanet...... 2229 ★ ToxServices LLC...... 1911 ToxStrategies...... 732 Search by Toxys ...... 2214 exhibitor name, TPL Pathology Labs R&D...... 1038, 1039 Translational Bioscience Inc...... 639 product category, Trevigen Inc...... 1810 or using the Triangle Research Labs, LLC...... 1736 interactive TSE Systems, Inc...... 1927 floor plan. U Begins on page 127. US Army Medical Research Institute of Chemical Defense (USAMRICD)...... 419 US EPA/Office of Research and Development...... 2133

♦ 2015 Diamond Sponsor | ✯ 2015 Sponsor 9 For up-to-date information use 25 years or more Exhibitor are Bold | ▲ SOT Affiliates the SOT Mobile Event App or the Online Planner GENERAL INFORMATION

Badge Barcode/Lead Retrieval Emergency/Facility Security All 2015 Annual Meeting badges feature a barcode on the back. If an emergency should occur while at the San Diego Convention The badge barcode is embedded with the attendee name, affiliation, Center, proceed directly to the nearest house phone, located address, fax, phone, and email. Exhibiting companies have the throughout the facility, and dial 5911 for security. You will be ability to collect this data with a lead retrieval machine and can connected directly to the 24-hour security department at the use the above mentioned information for solicitation. It is the goal Convention Center. of SOT to protect your privacy; therefore, if you do not wish your A First Aid room will be located in Box Office A, near Registration. badge to be scanned by an exhibiting company, please inform the exhibiting company of your wishes. An emergency medical technician will be on duty: All information printed in this directory is represented verbatim as Saturday...... 12:00 Noon–6:00 PM it was provided by exhibiting organizations prior to February 12, Sunday...... 6:00 AM–8:00 PM 2015. Monday...... 7:00 AM–8:00 PM Tuesday...... 7:00 AM–8:00 PM Please visit ToxExpo.com for more information about toxicology Wednesday...... 7:00 AM–8:00 PM products and services. Thursday...... 7:00 AM–12:00 Noon Exhibit Hall Policy Please note that in accordance with regulations, the First Aid Administrator is not permitted to dispense any medication. Admittance to ToxExpo is limited to attendees with full registration. Guest/Spouse Registrants and children under the Food Services age of 15 are not allowed in the Exhibit Hall. Photography is prohibited in the Exhibit Hall. Special requests can be brought to Coffee Breaks the Show Manager. The exhibiting companies are pleased to sponsor complimentary Exhibit hours are: coffee in the Exhibit Hall between 9:00 am–10:00 am Monday– Wednesday. See Exhibit Hall signage for locations. Monday...... 9:00 AM–4:30 PM Tuesday...... 8:30 AM–4:30 PM Concessions Wednesday...... 8:30 AM–4:30 PM GENERAL INFORMATION Concession stands are available in Exhibit Hall Monday at 9:00 A map of the ToxExpo is located on page 4. am–2:00 pm and Tuesday-Wednesday at 8:30 am–2:00 pm. Breakfast and lunch items will be available for purchase, as well Exhibitor Information as coffee, soda, bottled water, and snacks. Seating is available in the Concession areas in the Exhibit Hall. Concessions are run by ToxExpo 2016 Exhibit Space Selection Process SDCC Catering, providing food and beverages in the San Diego Convention Center. Priority Point booth sales for 2016 will take place on an appointment basis at the ToxExpo Sales Office. Companies in higher point levels will be contacted in advance of the show with their scheduled appointment time. If you did not receive an appointment in advance, please plan to attend the 2016 Sales Meeting on Tuesday, March 24, at 4:45 pm in Room 3.

Diamond Level Supporter Prize Drawing Win $500!

Drawings to take place on Monday, Tuesday, and Wednesday in the ToxExpo. $500 American Express Gift Card awarded each day. Drop your business cards in the ToxExpo prize drawing boxes found in all Diamond Level Exhibitor Supporter booths, see t on map. Booth Page ♦ Battelle 1727 36 ♦ Charles River 1326 45 ♦ National Institute of Environmental Health Sciences (NIEHS) 2228 92 ♦ Pfi zer Worldwide Research and Development 1321 99 ♦ SOT Endowment Fund, Society of Toxicology 526 115 ♦ WuXi AppTec 1833 133

Products and Services 365 days of the year—Visit ToxExpo.com 10 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo GENERAL INFORMATION

Global Gallery of Toxicology Networking Time All Global Gallery Posters are displayed Monday–Wednesday The Scientific Program Committee has dedicated time on Tuesday, during ToxExpo. March 24, for attendee networking. We encourage you to connect and engage with your colleagues at the Annual Meeting from Representative Attended: Monday, March 23, 11:45 am–12:15 pm. 12:00 noon to 1:30 pm on Tuesday between sessions. Only Toxicology Societies from around the world are invited to networking events and Exhibit Hall activities are scheduled during participate in the Global Gallery of Toxicology. Now in its fifth this time. Head into ToxExpo to network with your colleagues and year, posters showcasing the key information, accomplishments and expand your network! strategic initiatives of these societies will be prominently displayed during the Annual Meeting. Attendees interested in collaboration Noncontracted Exhibit Space and discussion are invited to a special “Representative Attended” Persons, companies, or organizations that have not contracted with poster time from 11:45 am–12:15 pm on Monday, March 23. The SOT to occupy space in the Exhibit Hall will not be permitted goal of all of these societies is to further the science of toxicology to display or demonstrate products, processes or services, solicit and to advance human health and disease prevention. The Global orders or distribute advertising materials in the convention center, Gallery posters are located prominently in the Exhibit Hall adjacent parking lots or in any hotel contracted by SOT. Solicitation beyond to the SOT Pavilion, Booth 526. an exhibitor’s booth, or by anyone other than approved exhibitors, is Internet Access at the San Diego strictly prohibited. Convention Center Recording, Photography, and SOT knows the importance of staying connected to your daily Cell Phone Policies activities while attending the Annual Meeting and provides The Society does not permit photography or the electronic capture several ways for you to access the Internet while at the San Diego of scientific sessions in meeting rooms or the ToxExpo without the Convention Center. consent of the session chair and the presenter(s)/author(s). Free Wireless Internet Access SOT WiFi This policy also includes photographing colleagues against the As a service to Annual Meeting attendees, SOT will be providing backdrop of scientific posters on display without the express consent free wireless Internet access in designated areas of the San Diego of the presenting author(s). Convention Center. SOT is providing wireless Internet access to • Photographing exhibit booths is prohibited. help attendees access a new Mobile Event App and help make the • Electronic capture of scientific sessions by any Annual Meeting a more productive and enjoyable experience. method is prohibited. To connect to the free wireless Internet, browse the available • All cell phones and electronic devices must be put on wireless networks and select the SOT2015 wireless network. When mute while attending scientific sessions. prompted for a password, use sotguest to connect to the network. nd UND a E 5 R Once connected, launch your web browser and the SOT welcome 1 • Children under the age of 15 are not allowed in the splashpage will automatically load. ToxExpo or in scientific sessions unless the session chair gives consent. @SOT—Internet Access The policies adopted above will be enforced by the Society. Those SOT will provide computers you can use to access the Internet. INFORMATION GENERAL individuals who do not comply will be asked to leave the session or These computers are available to attendees in the @SOT center, ToxExpo floor. If you have any questions regarding these policies, located on the Ground Level of the San Diego Convention Center. please contact the SOT Headquarters Office.

Lost and Found Prize Drawings Lost and found articles may be taken to the SOT Headquarters Exhibitor Prize Drawings: Office, Room 15A, of the San Diego Convention Center. Any items left in the office after 11:30 am, Thursday, March 26, will be taken Many exhibitors are giving away prizes at ToxExpo on Wednesday, back to SOT Headquarters. If you do not remove your poster at the March 25. Winners will be announced on the Public Address end of your session, you will find it on the “Poster Retrieval Tables” System in ToxExpo at 12:30 pm. Participating exhibitors can post located in the Exhibit Hall. Any posters left behind at 4:30 pm on a notice on the boards located in the Concession areas. Be sure Wednesday will be taken to SOT Headquarters Office, Room 15A, to stop by those exhibitors’ booths before Wednesday morning to Thursday morning, March 26. All posters not claimed by 1:00 pm enter each of the prize drawings. Each company will conduct their on Thursday, March 26, will be recycled. drawing at 11:00 am on Wednesday. Be sure to get lunch at one of the concession stands in the hall on Wednesday and listen for your name to be called at 12:30 pm.

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Diamond Level Supporter Daily Prize Drawings SOT Security and Safety SOT/ToxExpo will conduct one daily prize drawing for a $500 The possibility of demonstrators is very real given the nature of American Express Gift card. Stop by the Diamond Level Exhibitor our conference. Activities might range from verbal confrontations, Supporter booths to drop off your business card. Winners will be protests, and strikes, to riots. We recommend the following announced at 12:30 pm each day. procedures: ♦ Battelle 1727 • Have your name badge available upon entering the convention ♦ Charles River 1326 ♦ center. Wear your name badge in the convention center. When National Institute of Environmental leaving the facility, remove it so as to blend with other people. Health Sciences (NIEHS) 2228 Conceal bags and other items that might identify you as an SOT ♦ SOT Endowment Fund, Society of Toxicology 526 meeting attendee. ♦ WuXi AppTec 1833 • If you see a demonstration or protest beginning, please contact SOT Headquarters Office any member of the SOT Annual Meeting staff and they will initiate an SOT response. If you see actions that appear The SOT Headquarters Office is located in the San Diego threatening, notify the nearest security officer. Convention Center Room 15A on the Mezzanine Level. SOT leadership and staff utilize this office to conduct SOT business • Do not engage, defend either side, or subdue person(s) in any while on-site. Use the office to report or reclaim lost and found type of disturbance. Demonstrators are usually trying to attract items at the San Diego Convention Center. media attention. Don’t help them! SOT Headquarters Office hours: • SOT representatives will respond to media inquiries. Do not participate in interviews or other media responses. Saturday...... 4:00 PM–7:00 PM Sunday...... 7:00 AM–5:30 PM • In the unlikely event that outsiders disrupt a scientific session or Monday...... 7:00 AM–5:00 PM other event, SOT security officials have developed a contingency Tuesday...... 7:00 AM–4:30 PM plan. Please follow directions from the chairperson and avoid Wednesday...... 7:00 AM–4:30 PM becoming involved in the situation. Thursday...... 7:00 AM–12:00 Noon Safety Tips

GENERAL INFORMATION Walk “smart” when you leave the convention center: SOT Pavilion, Booth 526 • Know your destination and the best way to reach it. Located at Booth 526 in the ToxExpo Exhibit Hall, the SOT Pavilion is the place for you to connect and learn about SOT • Travel along sidewalks in lighted areas at night, and don’t walk programs, services, membership benefits, and more. Find out alone. about the SOT Endowment Fund, Toxicological Sciences, SOT • Establish a “buddy” system with another attendee to walk to and awards, supported awards and fellowships, ToXchange—the SOT from the convention center. member network, educational programs from K–12 throughout • Share schedules and check up on each other periodically. the toxicology career, and everything taking place at the Annual Meeting. • Build your awareness of unknown surroundings by reviewing local information. All SOT Annual Meeting attendees are welcome to stop by at any time during ToxExpo hours. • Laptop computers, smartphones, and electronic tablets are attractive, easy targets for thieves. Be sure they are stored in a Pavilion hours: secure place. Monday...... 9:00 AM–4:30 PM • Jackets with pockets provide a convenient alternative to reduce Tuesday...... 8:30 AM–4:30 PM the chance for lost or stolen handbags. Wednesday...... 8:30 AM–4:30 PM Our first priority is safety. The best way to stay safe is to be Be sure to stop by during the scheduled events for specific aware of your surroundings and to avoid situations where you feel information on programs and/or component groups. uncomfortable. A schedule of events is on page 56 of the Program and available in the SOT mobile event app.

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The Premier Gathering for Toxicological Products and Services www.ToxExpo.com

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Monday, March 23 10:45 AM to 11:45 AM CC Room 24A Adapting Cell-Based Assays to 3D Culture Models 9:15 AM to 10:15 AM CC Room 24C Presented by: Promega Corporation 3D Microtissue Cultures: Use in Long-Term Hepatocyte ADME-Tox Studies Complex 3D cell culture models stretch the limits of assays designed for measuring cytotoxicity endpoints from monolayers Presented by: BioreclamationIVT and InSphero Inc. of cells. We will present factors to consider for designing and InSphero and BioreclamationIVT present the latest data validating performance of cell-based assays measuring viability on the characterization of 3D human liver microtissues (as an endpoint and in real time) and upstream cell stress events and their application to toxicity testing, drug metabolism leading to cytotoxicity. studies and disease modelling. In addition, the attendees will learn about donor-to-donor differences and the use of liver 10:45 AM to 11:45 AM CC Room 22 non-parenchymal cells for 3D liver cultures. Computational Approach to Managing Mutagenicity Risk for ICH M7 and Beyond 9:15 AM to 10:15 AM CC Room 22 Presented by: Lhasa Limited Considerations for Nonclinical Safety Testing of Biologics, Biosimilars, and Biobetters Lhasa Limited, the world leader for knowledge and data sharing in chemistry and the life sciences, will present their views and Presented by: Toxikon Corporation expertise in utilizing an integrated In silico solution to comply New biologics are submitted through an IND process similar with the ICH M7 guidelines. In addition, they will highlight to small molecules and require a full battery of safety testing. where in silico solutions provide further evidence of drug safety. Biosimilars follow a specific pathway, designed based on an innovator, and often have an abbreviated safety testing program. 10:45 AM to 11:45 AM CC Room 24C We will use case studies to illustrate the differences between the The Immunology of Immunogenicity? programs. Presented by: Huntingdon Life Sciences/Harlan Laboratories 9:15 AM to 10:15 AM CC Room 24B From Candidate Drug to Clinical POC: Managing the Immunogenicity is an occasional consequence of treatment Continuum with a broad range of biological products. The session will discuss some of the immunological mechanisms that result Presented by: Covance in immunogenicity and their relevance to clinical use of the Experts in safety, pharmacology, DMPK, regulatory and clinical therapeutic. The session is aimed at toxicologists keen to learn strategy discuss approaches to successfully develop a molecule more about the subject. from candidate selection through POC. We’ll focus on drug safety strategy as part of the overall drug development plan, and 10:45 AM to 11:45 AM CC Room 24B provide insights on the importance of scientific and operational Utilization of In Vitro Mechanistic and 3D Models to continuity to achieve regulatory milestones. Improve the Prediction of Hepatoxicity and Cardiotoxicity Presented by: Cyprotex 9:15 AM to 10:15 AM CC Room 24A Safety Biomarkers in Preclinical Studies: A Clinical This presentation will cover recent developments in the field of Pathology Perspective in vitro prediction of cardiotoxicity and hepatotoxicity. It will focus on the development of 3D cell-based cardiac and hepatic EXHIBITOR-HOSTED SESSIONS EXHIBITOR-HOSTED Presented by: MPI Research systems and their applicability in mechanistic mitochondrial This session will provide an overview of the current principles assays (Seahorse) and 3D high-content imaging. involved in the application of safety biomarkers in preclinical research studies focusing on study design strategies, organ 12:15 PM to 1:15 PM CC 24B system evaluation, and validation principles. Additionally, Alternative Methods in Inhalation Toxicology integration of biomarker data with other study endpoints (e.g. Presented by: Fraunhofer ITEM traditional clinical pathology and pathology) will be discussed. The session will focus on different alternative methods in inhalation toxicology: P.R.I.T. Expo Cube: an innovative in vitro exposure system, Precision Cut Lung Slices and Isolated Perfused Lung model as ex vivo techniques. Regulatory acceptance of these methods as well as in silico approaches will be critically discussed.

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12:15 PM to 1:15 PM CC 24A 1:45 PM to 2:45 PM CC Room 24A Overview of Cutaneous Safety and Efficacy Assessment with The Gut Microbiota As a Source of Variability in Animal Reconstructed Human Epidermis (RHE) Models Presented by: EPISKIN Academy Presented by: IDEXX Laboratories Releasing products to the market is a costly and long process Aaron Ericsson, DVM, PhD, will present data regarding for industry. According to some surveys (Olson 2000, Greaves differences in the gut microbiota of mice associated with 2004), classical approaches based on animal studies exhibit different genotypes, commercial source, and variables related weaknesses to predict some human toxicity. Skin shows the to husbandry; effects of the gut microbiota on host responses to poorest concordance (36 percent) between animal and human. non-specific stimuli; and cost-effective methods of monitoring and manipulating the gut microbiota of mice. 12:15 PM to 1:15 PM CC Room 24C The Göttingen Minipig As Experimental Model for Anti- 3:15 PM to 4:15 PM CC Room 24C Neoplastic Drug Toxicity 3D Microtissues Meet OMICS Technologies and High- Presented by: RTC and Ellegaard Göttingen Minipigs Content Imaging After a general overview of the comparative biology of minipigs, Presented by: InSphero Inc. results of a case study are presented, which highlight the OMICS technologies and high-content imaging have been relevance of minipigs as experimental models for toxicity demonstrated to be valuable tools to unravel biological pathways studies with anti-neoplastic drugs. Minipigs showed signs and phenotypic outcomes. This session aims to introduce the comparable to humans and a greater tolerance for the effects of use of confocal imaging techniques, transcriptomics, and Doxorubicin compared to dogs. proteomics in combination with organotypic 3D model systems to assess toxicological pathways and mechanisms. 1:45 PM to 2:45 PM CC Room 22 Alternative Models Developing in KIT for Predictive 3:15 PM to 4:15 PM CC Room 24A Toxicology Chemical Risk Assessment Best Practices Presented by: Korea Institute of Toxicology Presented by: NSF International Agenda—1) Tissue engineering for alternative toxicology; Chemical risk assessments establish compliance with 2) Predictive toxicology models based on the multiorgan regulation and permit informed decision-making in product interaction. development and stewardship. When properly conducted, they are crucial to sustainable commercialization and public health 1:45 PM to 2:45 PM CC Room 24C protection. This session will review best practices in developing Diabetes and Weaker Bones—Exploring the Connection scientifically credible environmental and human health risk Presented by: Charles River assessments and disseminating peer-reviewed risk values. Osteoporosis and increased fracture risk have been added to the 3:15 PM to 4:15 PM CC Room 22 long list of complications of diabetes. This session will explore Further Exploration of Study Design for Tg.rasH2 Mouse skeletal function and underlying mechanisms of compromised Carcinogenicity Studies bones in metabolic diseases and will highlight endpoints to be included in safety studies to monitor for all diabetic Presented by: BioReliance complications. BioReliance, the leader in transgenic carcinogenicity testing, will present the latest data from our historical database, the 1:45 PM to 2:45 PM CC Room 24B largest for these studies. BioReliance has recently published Solutions and Lessons Learned with Inhaled Compounds in several papers suggesting changes to the designs of Tg.rasH2 the Pharmaceutical and Chemical Industries: Perspective carcinogenicity studies. These suggestions will be discussed and Insights from Key Opinion Leaders James Swenberg and with data to support the hypotheses. Chet Leach 3:15 PM to 4:15 PM CC Room 24B Presented by: Lovelace Respiratory Research Institute In Silico Approach to the ICH M7 Challenges Case studies for the use of inhaled models of industrial Presented by: MultiCASE Inc chemicals and pharmaceutical development will be provided by keynote speakers James Swenberg, DACVP, DVM, PhD, and MultiCASE Inc, the leading provider of in silico toxicology Chet Leach, PhD, DABT. solutions for chemical and pharmaceutical industries, will share their experience and expertise in the ICH M7 challenges with comprehensive CASE Ultra solutions. Highlights, interpretation scenarios and case studies will be presented. EXHIBITOR-HOSTED SESSIONS

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Monday Continued 8:30 AM to 9:30 AM CC Room 24C Key Factors an End User Must Consider When Examining a 4:45 PM to 5:45 PM CC Room 24C Vendor’s Extractable/Leachable Program Practical SEND Planning and Implementation: Key Presented by: Toxikon Corporation Learnings from a Dedicated Community of Experience and Expertise Container closure suitability for a drug product necessitates the quantitative examination of leachable substances, obtained Presented by: Instem under simulated use conditions. Target leachates are selected This session will review the experiences of twenty-one sponsors by end users from extractable studies that must be adequate to and CROs across eleven countries that have completed or are capture and model the critical conditions of concern. implementing new processes for SEND. 8:30 AM to 9:30 AM CC Room 24B 4:45 PM to 5:45 PM CC Room 24A The Use of Human HepatoPac, an In Vitro Microliver Semi-Automatic Generation of Expert Reports for ICH M7 Platform, for Predictive Toxicology Regulatory Submissions Presented by: Hepregen Corporation Presented by: Leadscope, Inc. Current In vitro platforms to assess hepatotoxicity have been This session presents a semi-automated framework to rapidly poor predictors of In vivo performance. HepatoPac is a highly generate an M7 submission report containing an expert opinion predictive In vitro microliver platform demonstrated to improve that is transparent, complete, consistent, and traceable. sensitivity. It remains functional for several weeks, making it an ideal platform for “extended-horizon” scenarios, including 4:45 PM to 5:45 PM CC Room 24B chronic toxicity and DDIs. Strategies to Reduce Attrition in Early and Late Stages of Drug Development 10:00 AM to 11:00 AM CC Room 24B Presented by: APTUIT LLC Application of Color Calibration in Photomicrography for Toxicologic Pathology Besides being a regulatory requirement, electrophysiology can be used in early stages of drug development to allow the early Presented by: Datacolor Inc. detection of a potential cardiotoxicity. Abuse liability may In toxicologic pathology, it is critical that color in represent a risk to the development portfolio and appropriate photomicrographs accurately represent those seen in the abuse liability strategy may mean the difference between failure specimen. Consistency between images and image color and success of an asset. rendering on computer monitors is essential for viewing and evaluating images. Several case studies will illustrate the Tuesday, March 24 importance of color calibration to assessments by toxicologic pathology. 8:30 AM to 9:30 AM CC Room 22 Challenges, Conundrums, and the “Catch-22” in Abuse 10:00 AM to 11:00 AM CC Room 24C Liability Testing for NDA Approvals: The Bugaboo of In Vitro Hepatotoxicity Evaluation with Cryopreserved Biologics? Human, Animal, and Transgenic Animal Hepatocytes Presented by: MPI Research Presented by: In Vitro ADMET Laboratories, LLC There is a growing concern from the published literature that Application of plateable cryopreserved single donor and pooled EXHIBITOR-HOSTED SESSIONS EXHIBITOR-HOSTED some “biologic-products” on the market have the potential to be human hepatocytes, hepatocytes from multiple preclinical psychoactive or have the capacity not only to modify ongoing animal species, and transgenic knock-out and humanized behavior but also to enter into important behavioral population. mouse hepatocytes in hepatotoxicity evaluation will be discussed, with emphasis on early hepatotoxicity screening in 8:30 AM to 9:30 AM CC Room 24A drug development and the elucidation of species difference, Considerations and Challenges Associated with Medical individual difference, and toxicological pathways. Device Risk Assessment Presented by: WuXi AppTec Risk assessments based on chemical characterization data and intended use have recently become an integral component in the overall evaluation of medical device biocompatibility. Using ISO 10993-17 as a framework, the basic principles of risk assessment can be applied to the evaluation of medical device extracts.

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10:00 AM to 11:00 AM CC Room 22 11:30 AM to 12:30 PM CC Room 24A Less Compound, Less Cost—How to Succeed in Early-Phase Models of Chemical, Biological, Radiological, Nuclear, Inhalation Programs and Explosive (CBRNE) Threats: Considerations for Drug Presented by: Huntingdon Life Sciences/Harlan Development under the Animal Rule Laboratories Presented by: Lovelace Respiratory Research Institute As the cost of drug development increases, companies have CBRNE requires the integration of multidisciplinary teams prioritized early readout of efficacy and toxicity to limit the cost to do strategic studies for developing new drugs to protect the of late-stage failure. This session will discuss and demonstrate public and soldier. The animal models are complex and heavily approaches to test article conservation that can significantly integrated with pharmacology and toxicokinetics to enable reduce test article consumption while still providing translation. high-quality data. 11:30 AM to 12:30 PM CC Room 22 10:00 AM to 11:00 AM CC Room 24A Structural and Functional Endpoints in Repeat-Dose Overcoming Challenges during Preclinical Sample Collection Toxicity Cardiovascular Risk Assessments and the Use of In to Minimize the Impact on Toxicological Data Vivo Physiologic Monitoring Presented by: Algorithme Pharma Presented by: Data Sciences International When conducting preclinical studies, maintaining sample Cardiovascular liabilities are an important source of drug integrity following collection is critical. Due to the complexity development attrition. Risk assessment requires thorough of pharmaceutical compounds, challenges that can impact data understanding of the pathogenesis, structural, and functional reliability may occur during and following sample collection. changes. This presentation discusses the rationale for including Potential issues include whole blood stability, anticoagulants, structural and functional endpoints in repeat-dose toxicity acid and preservatives, hemolyzed plasma, and co-administered studies and the efficacy of gathering these endpoints via medications. implantable versus jacketed external telemetry.

11:30 AM to 12:30 PM CC Room 24C 1:00 PM to 2:00 PM CC Room 24A Fully Automated and Easy-to-Use Solution for Your Improved Methods for In Vivo and In Vitro Thrombogenicity Cytochrome p450 Gene Expression Testing Testing for Medical Devices Presented by: HTG Molecular Diagnostics Presented by: American Preclinical Services Drug-metabolizing enzymes and transporter induction can Thrombogenicity testing is a critical component of the ISO result in clinically meaningful drug interactions. Measuring 10993-4 testing required for medical devices. Refined methods gene expression has traditionally relied upon RNA extraction for in vivo thrombogenicity assessment using fluoroscopic from treated hepatocytes followed by RT-qPCR. An alternative, guidance and contrast-mediated flow visualization have been potentially more efficient method for measuring gene induction identified and will be discussed along with novel in vitro is the multiplex HTG Edge quantitative nuclease protection blood-loop methods that allow assessment of new materials. assay (HTG Edge chemistry). 1:00 PM to 2:00 PM CC Room 22 11:30 AM to 12:30 PM CC Room 24B Revised OECD Test Guidelines for Genetic Toxicology Making Cardiotoxicity Prediction Simple and Relevant: Presented by: BioReliance Human Ipsc-Cardiomyocytes and Integrated Impedance and Field Potential-Based Assays Enable Highly Predictive On September 26, 2014, four revised and one new OECD Cardiotoxicity Assessments across Multiple Mechanisms Testing Guideline for Genetic Toxicology were officially adopted. This educational session will review each of these Presented by: Cellular Dynamics International and ACEA guidelines, showing the improved sensitivity of new assay Biosciences requirements, and present how BioReliance has implemented Cardiotoxicity manifests through several distinct mechanisms. these in a GLP setting. This workshop will present (1) novel and peer-reviewed data using human cardiomyocytes with impedance and electrophysiological testing that validates a simplified and highly predictive workflow for electrical, biochemical, and contractile-based cardiotoxicity detection and (2) integration with the US FDA’s Comprehensive In vitro Proarrhythmia Assay (CiPA). EXHIBITOR-HOSTED SESSIONS

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Tuesday Continued 2:30 PM to 3:30 PM CC Room 24B Reproductive and Juvenile Studies in Minipigs 1:00 PM to 2:00 PM CC Room 24C Presented by: CiToxLAB and Ellegaard Göttingen Minipigs Usefulness of Biomarkers in Support of Preclinical Studies In this joint CiToxLAB/Ellegaard session we will present the Presented by: Charles River basic reproductive biology of Göttingen minipigs, theory, and A host of new biomarker methods and platforms are being practice of embryofetal toxicology studies in minipigs, and routinely developed and validated, increasing the reliance theory and practice of juvenile toxicity studies in minipigs. on biomarkers to evaluate the toxicity and/or efficacy of new The session, illustrated with case histories, should interest both drugs. This session will provide an overview of therapeutic area specialists and generalists! biomarkers and considerations for biomarker assay development in support of preclinical toxicology programs. 2:30 PM to 3:30 PM CC Room 22 The Path to Licensure: Ebola Vaccines 1:00 PM to 2:00 PM CC Room 24B Presented by: Battelle Using DRAGON to Implement Systematic Review: Lessons Learned The recent Ebola outbreak has highlighted the seriousness of emerging infectious diseases. As these diseases have garnered Presented by: ICF International greater attention, it has also become apparent that there are Implementing systematic review for broad environmental challenges associated with the regulatory pathways required health assessments is challenging. With the right tools, scientists to ensure safe and efficacious treatments in order to meet the can effectively integrate data streams to manage the process time-sensitive demands. including problem formation, literature screening, and risk of bias evaluation according to systematic review principles. 4:00 PM to 5:00 PM CC Room 22 ICF scientists will share lessons learned implementing these Efficiently Integrating CMC and Preclinical Safety/DMPK principles using DRAGON. to Streamline the Access to Phase I: Is the Balance between Speed, Cost, and Risk Management Possible? 2:30 PM to 3:30 PM CC Room 24C Presented by: APTUIT LLC 3D Liver Models and Beyond: 3D Hepatic, Cardiac, Pancreatic, and Neural Microtissue Models for Toxicity Integrated drug development is a complex endeavor and Testing requires a combination of multiple scientific and strategic competencies. Scientific, technical, and regulatory elements Presented by: InSphero Inc. supported by the right strategy drive the design of an optimal 3D liver microtissue models have demonstrated significant development plan, finding the right tailored balance between value as more organotypic systems for assessment of toxicity. streamlining, risk, and potential investments. This session aims to cover the latest studies characterizing 3D InSight™ liver microtissues, and introduce novel 3D models for 4:00 PM to 5:00 PM CC Room 24B assessment of toxicity in non-liver organs, focusing on the heart, SEND Compliance with US FDA Guidance pancreas, and brain. Presented by: PointCross LifeSciences, Inc 2:30 PM to 3:30 PM CC Room 24A A readiness plan to comply with the US FDA’s binding guidance Application Study: Human-Induced Pluripotent Stem (iPS) for standardized SEND submissions will be presented. Impacts Cell Assay As a Tool for Compound Ranking Based on on study design, data collection and preparation, submission, EXHIBITOR-HOSTED SESSIONS EXHIBITOR-HOSTED Human Developmental Toxicity Potential and review will be discussed. Lessons learned from the US FDA’s NIMS review tool and JumpStart Nonclinical Service and Presented by: Stemina Biomarker Discovery, Inc. from sponsor implementations will be presented. A human stem cell-based predictive model of human developmental toxicity can be applied to rank compounds by their relative teratogenic potency. Testing in a series of retinoids will provide an example. This approach can be applied to compound series in the discovery phase, or as a bridging study to enable read-across assessment.

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4:00 PM to 5:00 PM CC Room 24C 9:15 AM to 10:15 AM CC Room 24B Stem Cell-Derived Hepatocytes with Enhanced Drug Metabolites in Safety Testing—A Novel Key to Turn for Your Metabolizing Functions 3Rs Initiatives Presented by: Takara Bio Europe AB (formerly Cellartis) Presented by: Covance Cellartis® Enhanced hiPS-HEP is a highly homogenous The changing pharmaceutical environment is delaying population of human iPSC-derived hepatocytes with significant definitive non-clinical and clinical testing to after Phase IIB. activity levels of relevant CYPs. These cells are ideal for use in Yet increasing regulatory requirements force organizations to toxicology-related applications and drug metabolism studies look for alternative development plans. Utilizing connections that demand substantial expression of drug metabolism between toxicology and metabolism can help to de-risk enzymes, a highly reproducible platform, and continuous supply programs and help to blaze a path forward. of material from the same genetic background. 10:45 AM to 11:45 AM CC Room 24C 4:00 PM to 5:00 PM CC Room 24A Blending Biocompatibility and Pharmaceutical Testing Utilization of the Impedance-Based xCELLigence Real-Time Processes to Obtain Sub-Acute, Sub-Chronic, and Chronic Cell Analysis (RTCA) Technology for In Vitro Health Risk Toxicity Evaluations of Medical Devices Assessment Presented by: Toxikon Corporation Presented by: Alberta Centre for Toxicology and The Certain medical devices require systemic toxicity tests. Hamner Institutes Addressing the requirements of ISO 10993-11 and regulators There is an unmet need for In vitro toxicity bioassay with higher abroad requires an understanding of the requirements as well sensitivity, lower interference, and better predictive value. In as the limitations of the animal models. Utilizing requirements this workshop, two institutions will share their experience with required of pharmaceuticals and adjusting them to the the impedance-based xCELLigence RTCA technology for the in application of ISO 10993-11 provides for a robust study. vitro assessment of water and food safety. 10:45 AM to 11:45 AM CC Room 24B Wednesday, March 25 HμREL: “Plug-and-Play” Primary Hepatic Models for a Variety of Definitive Hepatotoxicity Applications 9:15 AM to 10:15 AM CC Room 24A Presented by: Hurel Corporation Application of Molecular Imaging and Radiochemistry in Hμrel’s primary hepatic co-cultures maintain hepatic functions Drug Development over time, making Hμrel’s co-culture models ideal for extended Presented by: MPI Research in vitro hepatotoxicity monitoring. Our symposium will Contemporary drug development is a lengthy process. demonstrate Hμrel’s co-culture system for a variety of in Molecular imaging (MI) has become a solution to decrease vitro toxicity applications, including: high content analysis, development time via assessment of specific molecular targets. “real-time” hepatotoxicity monitoring (ACEA Biosciences), and MI is a multidisciplinary field evaluating biological processes at Hμrel’s microfluidic Hμrelflow™. the molecular and cellular levels in vivo. This session focuses on application of molecular imaging drug development. 10:45 AM to 11:45 AM CC Room 24A Unraveling the Gordian Knot of Predictive Toxicology: Can 9:15 AM to 10:15 AM CC Room 24C Next-Gen Culture Systems Solve the Puzzle? Consequences of Immunogenicity in Nonclinical Safety Presented by: Organovo Studies How well do your preclinical models translate to the clinic? Presented by: Charles River Better prediction of human outcomes will require new strategies In nonclinical safety testing, biotherapeutics have the that accurately model human tissue complexity. Join us for a potential to induce an immune response. This session thought-provoking panel discussion on the opportunities and will cover the effects of immunogenicity responses to challenges created in the application of next-gen culture systems biotherapeutics, including the approach taken to determine to the drug development process. immunogenicity involvement and the methods for predicting clinical immunogenicity. Nonclinical case studies on adverse immunogenicity events will be presented. EXHIBITOR-HOSTED SESSIONS

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Wednesday Continued 1:45 PM to 2:45 PM CC Room 24B Advanced In Vitro ADME and Toxicology Services Designed 12:15 PM to 1:15 PM CC Room 24C to Improve Drug Safety and Efficacy Advances in In Vitro and In Silico Techniques: Regulatory Presented by: BioReliance Acceptance Worldwide BioReliance, a scientific leader in toxicology for more than 50 Presented by: Huntingdon Life Sciences/Harlan years, is introducing a suite of advanced In vitro ADME/Tox Laboratories assays and services designed to improve drug safety and efficacy. Advances in in vitro and in silico estimation of toxicological Drug safety, transporter, and metabolism data generated in end points have challenged traditional approaches to safety novel liver, kidney, and intestinal cell lines will be presented. assessment. The acceptability of these new methodologies has been acknowledged by regulatory authorities, worldwide. We 1:45 PM to 2:45 PM CC Room 24C discuss our experiences in using these techniques to achieve Characterizing In Vitro-Generated Mouse Cardiomyocytes regulatory success in a range of product types. by RNA-Seq using QIAGEN’s Ingenuity Pathway Analysis (IPA) 12:15 PM to 1:15 PM CC Room 24A Presented by: QIAGEN Bioinformatics Kidney Toxicity Biomarker Analysis Tips from the Experts: Why Just Multiplex When You Can MILLIPLEX? IPA was used to characterize the transcriptome during the differentiation of cardiomyocytes from mouse ES cells. Such Presented by: EMD Millipore cells can be useful for compound toxicity screening and a means In collaboration with Pfizer, EMD Millipore’s assay developers to reduce the use of animals. IPA maximizes insight into the designed a bead-based multiplex assay to simultaneously biology of the cells via individual isoforms expressed as the cells measure multiple, PSTC-qualified kidney injury biomarkers in mature. dog urine. Join us to participate in an interactive demonstration of MILLIPLEX® MAP Canine Kidney Toxicity assays to 1:45 PM to 2:45 PM CC Room 24A simultaneously detect low-level biomarkers using the Luminex Sharpen the Focus of Your Toxicology Research Program MAGPIX® instrument. Using Agilent’s Integrated Biology ‘Omics Solutions Presented by: Agilent Technologies 12:15 PM to 1:15 PM CC Room 24B MicroRNA in Biofluids—Robust Biomarkers for Disease, Agilent’s GeneSpring Multiomics Suite enables insights to Toxicology, or Injury Studies be gained in underlying mechanisms of toxicity through the analysis and visualization of multiomic data and mapping Presented by: Exiqon of affected pathways. Come to our workshop to learn about MicroRNAs represent the best characterized class of small how it is being used to advance understanding of mechanisms RNAs (21-23nt) which are rapidly becoming recognized as underpinning endocrine disruption. promising biomarkers in toxicology. MicroRAs are highly stable in common clinical sample types like plasma serum, and urine where their levels may be dramatically altered in response to drug-induced toxicity. Diamond Level Supporter Prize Drawing Win $500! EXHIBITOR-HOSTED SESSIONS EXHIBITOR-HOSTED Drawings to take place on Monday, Tuesday, and Wednesday in the ToxExpo. $500 American Express Gift Card awarded each day. Drop your business cards in the ToxExpo prize drawing boxes found in all Diamond Level Exhibitor Supporter booths, see t on map. Booth Page ♦ Battelle 1727 36 ♦ Charles River 1326 45 ♦ National Institute of Environmental Health Sciences (NIEHS) 2228 92 ♦ Pfi zer Worldwide Research and Development 1321 99 ♦ SOT Endowment Fund, Society of Toxicology 526 115 ♦ WuXi AppTec 1833 133

Products and Services 365 days of the year—Visit ToxExpo.com 20 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo The Society of Toxicology 2015 Mobile Event App Quick Start Guide Download the app (SOT2015) from your app market place or access the Mobile Event App and Online Planner at http://www.toxicology.org/sot2015

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Use the enhanced Scroll down to view additional search tool: icon buttons for each of the Schedule: features and tools within the by Session Title app Abstracts: by Title, Keyword, Number, Author Name or Affi liation, Log in to customize the app— or Abstract Content select the My Schedule button to prompt the login (same as Speakers: your SOT website login) by Name or Affi liation Exhibitors: Log in to message to other by Company Name, Booth Annual Meeting attendees Number, or Product Categories Use the gear icon to access Use the More option to view your profi le and manage additional features in the app privacy settings

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ABC Laboratories 1236 7200 ABC Lane Columbia, MO 65202 United States Tel: 573.777.6209 Fax: 573.777.6033 Email: [email protected] Website: www.abclabs.com Since 1968, ABC has been delivering analytical expertise in support of product development. But like the industries we serve, our company has changed. Today’s ABC offers more than superior science and regulatory rigor. Through development know-how, cross- disciplinary technical expertise, and applied experience with multiple regulatory frameworks, ABC delivers the kind of insight that drives better outcomes. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Aquatic Sciences/Testing, Bioanalytical Services, Chemical Synthesis, Environmental Chemistry/Fate Absorption Systems 309 436 Creamery Way Exton, PA 19341 United States Tel: 610.280.1428 Email: [email protected] Website: www.absorption.com Absorption Systems is a preclinical CRO specializing in PK and toxicology studies conducted in our AAALAC-accredited facility. We can help identify the most appropriate species based on metabolite profiling and develop optimized formulations for difficult compounds. Our facilities of nearly 50,000 sq. ft. are strategically located on both coasts. Our reputation for scientific expertise, outstanding customer service, and high-quality data make us the leading choice for your outsourcing needs. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Bioanalytical Services, CRO—Contract Research Organization, In Vivo Research/Testing, Medical Devices/Testing Accelera S.r.l. 2220 Viale Pasteur 10 Nerviano (Milano), 20014 Italy Tel: +39-0331-1984 257 Fax: +39.0331-1984.200 Email: [email protected] Website: www.accelera.org Accelera, the CRO of choice as a drug development partner for pharma and biotech companies around the world. From our unique history Accelera offers a unique range of integrated and tailored drug discovery and development services: Full IND-enabling packages; Regulatory Toxicology (including NHP); Biologics and Biomarkers; Safety Pharmacology; ADME/PK; Preclinical and Clinical bioanalysis; HTP Preclinical Profiling; Cancer Pharmacology; Regulatory Consultancy. With Accelera, experience results. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), CRO–Contract Research Organization, Infusion Equipment, Primate Supplies/Testing, Reproductive Toxicology

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ACEA Biosciences, Inc. 906 6779 Mesa Ridge Road, #100 San Diego, CA 92121 United States Tel: 858.724.0928 Toll Free: 866.308.2232 Fax: 858.724.0927 Email: [email protected] Website: www.aceabio.com EXHIBITOR DESCRIPTIONS EXHIBITOR ACEA Biosciences, Inc. is a pioneer in the development and commercialization of high-performance microelectronic systems for cell-based assays. Among the six systems available, the xCELLigenceÒ RTCA-Cardio System monitors the beating function of cardiomyocytes in real time, providing a high-throughput, quantitative, and predictive assay system for early detection of cardiac liabilities of drug candidates. For more information, please visit our website at www.aceabio.com. Product Categories: Biotechnology Products, Instruments, Research, Safety Assessment ACGIH® 610 1330 Kemper Meadow Drive Cincinnati, OH 45240 United States Tel: 513.742.2020 Fax: 513.742.3355 Email: [email protected] Website: www.acgih.org ACGIH® is a scientific organization that advances occupational and environmental health. Examples include our annual editions of the TLVs® and BEIs® and other scientific guidelines in ACGIH‘s Signature Publications Series. At ToxExpo we will showcase the outstanding educational events, publications, and software for which ACGIH is renowned. Information regarding membership will also be available. Please stop by and see us. Product Categories: Education, Industrial Hygiene, International Organizations, Organizations, Publishers Advinus Therapeutics Limited 2121 21/22, Phase II, Peenya Industrial Area Bangalore, 500058 India Tel: +91 80 2839 4959 Fax: +91 80 2839 4015 Email: [email protected] Website: www.advinus.com Advinus is the Most Experienced Toxicology Center promoted by TATAs catering to pharma, agro and chemical sectors. This highly- accredited center (GLP since 1992) has the largest vivarium in India which is AAALAC-certified with ADME, Genotox, Safety Pharm, General Tox, Reprotox, Ecotox capabilities. Conducted >50 Carci studies including Transgenic. Track record of 30 IND and >6000 standalone toxicology studies submissions globally. Expertise of infusion administration up to 1 h in rodents and nonrodents. Product Categories: Acute Toxicology Services/Testing, ADME (Absorption/Distribution/Metabolism/Excretion), Agrochemical Product Safety/Toxicology, CRO—Contract Research Organization, Ecology/Ecotoxicology Services

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AEgis Technologies Group 1000

410 Jan Davis Drive Please see our ad on page 25. Huntsville, AL 35806 United States Tel: 407.380.5001 Fax: 407.380.7902 Email: [email protected] Website: www.acslx.com AEgis Technologies provides modeling and simulation software tools, support, training, and consulting services to scientists working in pharmaceutical and toxicological research around the world. AEgis’ family of software tools for PK/PD/PBPK modeling, computational biology, and risk assessment includes: the acslX environment for modeling and simulation of biological systems, ADME Workbench for flexible, robust pharmacokinetic modeling, and NSAP for safety assessment of engineered nanomaterials. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Pharmacokinetics, Risk Assessment, Software, Toxicokinetics Agena Bioscience 939 3565 General Atomics Court San Diego, CA 92121 United States Tel: 877.443.6663 Email: [email protected] Website: www.agenabio.com Use Agena Bioscience's nucleic acid detection and quantification technology (the MassARRAY® System), for flexible and cost- effective analysis of genetic polymorphisms in drug ADME/T. Analyze SNPs, insertions and deletions, and copy number variations (CNVs) in ten, to hundreds of samples per day. Select from the ADME PGx Pro Panel (36 key genes, 99% of PharmaADME working group core list), focused sets (CYP2D6, CYP2C19, and CYP2C9/VKORC1) or a custom assay set designed to meet your exact needs. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Cancer Biology/Carcinogenicity, Genomics Research/Testing, Toxicogenomics AI BioTech, LLC 1003 601 Biotech Drive Richmond, VA 23235 United States Tel: 804.521.7377 Toll Free: 844.466.8668 Fax: 804.977.5038 Email: [email protected] Website: www.aibiotech.com AI BioTech is a comprehensive CRO providing research and development services to the biotechnology industry, academic institutions, pharmaceutical companies, and government agencies. We provide a multifaceted, integrated approach to research and project support under GLP and CLIA guidelines. We are also accredited by CAP. Our ImmunoTox division offers validated immune system related assays in support of preclinical and human clinical studies. Product Categories: Bioanalytical Services, Biochemistry, Genomics Research/Testing, Immunology Research/Testing, LC/MS— Liquid Chromatography/Mass Spectroscopy

Products and Services 365 days of the year—Visit ToxExpo.com 24 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo Follow us on Twitter at @SOToxicology and @ToxExpo 25 For up-to-date information use Tweet using #2015SOT and #toxexpo the SOT Mobile Event App or the Online Planner EXHIBITOR DESCRIPTIONS EXHIBITOR DESCRIPTIONS

Alabama Research & Development 1541 152 Metal Samples Road Munford, AL 36268 United States Tel: 256.358.0460 Email: [email protected] Website: www.tissueslicer.com The Krumdieck MD6000 Live Tissue Microtome is designed to prepare thin reproducible tissue slices suitable for toxicology studies. It features a user-friendly touch screen with separate speed controls for the blade and reciprocating arm. It includes a revised blade holder to improve stability for more consistent slices. A counterbalanced drive shaft reduces noise and vibration. We also manufacture accessories for tissue coring, embedding, and incubation. Product Categories: Microtomes, Tissue Equipment/Research/Supplies ALCEDIAG 635 Cap Delta 1682 rue de la Valsiere Montpellier, 34184 France Tel: +33 (0)467406110 Email: [email protected] Website: www.alcediag-alcen.com ALCEDIAG creates and commercializes highly innovative approaches for medical diagnostics and predictive toxicology. The company aims at identifying new biological markers, improving technologies along with algorithms for personalized medicine. Our in vitro screening test, EDITOX, offers a predictive tool to reduce the risk of severe adverse psychiatric effects. Our algorithm identifies 97% of at risk compounds offering a rapid and robust rule-out test used in drug development strategies. Product Categories: Acute Toxicology Services/Testing, In Vitro Research/Testing, Preclinical Research/Testing, Risk Assessment, Toxicogenomics Alconox, Inc. 1630 30 Glenn Street, Suite 309 White Plains, NY 10603 United States Tel: 914.948.4040 Email: [email protected] Website: www.alconox.com Alconox, Inc. is dedicated to being the leader in critical cleaning detergents. We manufacture quality detergents made in the United States and provide outstanding technical service to the scientists and engineers with precision cleaning needs. Service to the industry, precision formulation, quality control, and excellent technical services are the benchmarks of Alconox, Inc. Our customer support team can recommend solutions to specific precision cleaning problems. Product Categories: Chemical Product Safety/Toxicology Algorithme Pharma 1141 575 Armand Frappier Laval, QC H7V 4B3 Canada Tel: +450.973.6077 Email: [email protected] Website: www.algopharm.com Altasciences, a holding company, includes Algorithme Pharma (Canada and USA) and Vince & Associates Clinical Research, providing comprehensive early stage clinical drug development services in Phase I/IIa, including the necessary support services in this critical stage of drug development. Their successful recruitment and retention of special populations in increasingly complex early development clinical trials allows Altasciences to best meet the changing needs of our industry. Product Categories: Bioanalytical Services, CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, Pharmacokinetics, Preclinical Research/Testing

Products and Services 365 days of the year—Visit ToxExpo.com 26 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo EXHIBITOR DESCRIPTIONS

Alliance Pharma 1207 17 Lee Boulevard Malvern, PA 19355 United States Tel: 610.608.5917 Email: [email protected] Website: www.alliancepharmaco.com As a CRO, Alliance Pharma, Inc. specializes in GLP and non-GLP bioanalytical (BA) services for both small and large molecules, as well as drug metabolism and pharmacokinetic (DMPK) support. We provide services for preclinical and clinical programs in the EXHIBITOR DESCRIPTIONS EXHIBITOR following areas: small molecule LC-MS/MS bioanalysis of drugs, biomarker and agrochemicals, large molecule immunoassays to support PK, immunogenicity studies and biomarker analysis, cell based assays, drug metabolism studies. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Bioanalytical Services, CRO—Contract Research Organization, LC/MS-Liquid Chromatography/Mass Spectroscopy, Pharmacokinetics Alpha Genesis, Inc. (AGI) 900

95 Castle Hall Road Please see our ad on page 31. Yemassee, SC 29945 United States Tel: 843.589.5190 Fax: 843.589.5290 Email: [email protected] Website: www.alphagenesisinc.com Alpha Genesis, Inc. (AGI) is a direct provider of nonhuman primates to the biomedical research community. AGI is dedicated to high- quality management and oversight of its primate colonies, and is one of the few providers to offer both US bred and imported primate research models conditioned to meet your specific research needs. Proven breeding programs and AAALAC-accredited facilities translate into the best care and preparation of primates to meet your research needs. Product Categories: Animal Models, Cells/Tissue, Preclinical Research/Testing Alpha MED Scientific Inc. 2211 209, 7-7-15, Saito-asagi Ibaraki, Osaka 567-0085 Japan Tel: +81-72-648-7973 Email: [email protected] Website: www.med64.com Alpha MED Scientific provides the MED64 micro-electrode array (MEA) system for in vitro electrophysiology. With its industry's most-sensitive electrodes, the MED64 provides clean and accurate electrophysiological recordings, enabling advanced semi- automated drug screening and safety screening. The new medium throughput system will enable you to perform high-quality drug and safety screening for up to 8 samples simultaneously and is easily scalable for testing hundreds of compounds. Product Categories: Chronic Toxicology, In Vitro Equipment/Supplies, Pharmaceutical Product Safety/Toxicology, Pharmacology

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Alturas Analytics, Inc. 1802 1324 Alturas Drive Moscow, ID 83843 United States Tel: 208.883.3400 Toll Free: 877.344.1279 Fax: 208.882.9246 Email: [email protected] Website: www.alturasanalytics.com Alturas Analytics, Inc. is a research-intensive CRO specializing in LC-MS/MS bioanalysis of small and large molecules. GLP and non-GLP services include bioanalytical method development and validation, routine quantitative analysis of preclinical and clinical samples, PK and TK analysis and protein binding determinations. Alturas is on the leading edge of antibody and biomarker analysis using LC-MS/MS techniques, as well as the world leader in Dried Blood Spot (DBS) and novel Dried Matrix Spot (DMS) analysis. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Bioanalytical Services, Biomarkers, GLP—Good Laboratory Practice Services, LC/MS—Liquid Chromatography/Mass Spectroscopy American Board of Toxicology (ABT) 1307 PO Box 97786 Raleigh, NC 27624 United States Tel: 919.841.5022 Fax: 919.841.5042 Email: [email protected] Website: www.abtox.org ABT was founded to establish a process for certification which would evaluate and document competency in the field of toxicology. ABT's purposes are to encourage the study of toxicology, to stimulate its advancement by establishing standards for professional practice, to prepare and administer procedures including tests for the implementation of such standards, and to confer recognition upon those members of the profession who, measured against such standards, demonstrate competence. Product Categories: Accreditation, Organizations American College of Toxicology (ACT) 736 1821 Michael Faraday Drive, Suite 300 ★ 2015 Silver Level Supporter Reston, VA 20190 United States Tel: 703.547.0875 Email: [email protected] Website: www.actox.org The American College of Toxicology is a premier organization that educates, leads, and serves professionals in toxicology and related disciplines by promoting the exchange of information and perspectives on applied toxicology and safety assessment. The benefits of membership are numerous, including attendance to ACT’s Annual Meetings and educational courses at a reduced rate, opportunities for professional networking, subscription to the International Journal of Toxicology, and access to the online membership directory and to various educational resources. Product Categories: Education, International Organizations, Organizations, Pharmaceutical Product Safety/Toxicology

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American College of Veterinary Ophthalmologists 2141 PO Box 1311 Meridian, ID 83680 United States Tel: 208.466.7624 Email: [email protected] Website: www.acvo.org The American College of Veterinary Ophthalmologists is the organization of board certified veterinary ophthalmologists. These specialists are uniquely qualified to consult in the preclinical GLP assessment of ocular toxicity in general toxicology and ocular EXHIBITOR DESCRIPTIONS EXHIBITOR specific studies. Veterinary ophthalmologists have the necessary skills for administration of test article directly into the eye, including subconjunctival, anterior chamber, intravitreal, and subretinal injections. Product Categories: Clinical Toxicology/Toxicology, Ophthalmic Products, Ophthalmic Research/Testing, Veterinary Consulting/ Services American Preclinical Services 1933 8945 Evergreen Boulevard NW Minneapolis, MN 55433 United States Tel: 763.717.7990 Fax: 763.717.2042 Email: [email protected] Website: www.americanpreclinical.com American Preclinical Services (APS) is your trusted preclinical CRO partner. APS provides the full array of ISO 10993 biocompatibility testing, hospital grade surgical, and catheterization labs, state-of-the-art medical diagnostic imaging and histopathology services. APS operates an AAALAC-accredited facility and offers GLP-compliant studies. Our scientific and veterinary staff have decades of industry research experience spanning all major organ systems and preclinical disciplines. Product Categories: Genotoxicity Products/Services, Histopathology, In Vitro Research/Testing, In Vivo Research/Testing, Medical Devices/Testing, Pathology, Pharmacology, Preclinical Research/Testing American Screening 2113 1651 East 70th Street PMB 404 Shreveport, LA 71105 United States Tel: 318.798.3306 Fax: 318.798.3386 Email: [email protected] Website: www.americanscreeningcorp.com American Screening’s drug testing products are designed for maximum accuracy with up to 99% accuracy rate, FDA 510K approval and CLIA Waived. Purchasing millions of tests each year enables us to extend discounted drug tests to our customers that the competition just can’t match. We have numerous certifications including ISO 13485 and Health Canada. Product Categories: Clinical Toxicology/Testing, In Vitro Research/Testing, Medical Devices/Testing, Photo-Biology/Toxicology Services/Testing

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Americans for Medical Progress 511 526 King Street, Suite 201 Alexandria, VA 22314 United States Tel: 703.836.9595 Fax: 703.836.9594 Email: [email protected] Website: www.amprogress.org Americans for Medical Progress is dedicated to protecting your investment in biomedical research. We focus on public outreach that builds understanding and appreciation for necessary and humane animal research. We also provide vital news, information and analysis to biomedical research stakeholders to ensure they have the resources they need to deflect campaigns that threaten the future of medical progress. Product Categories: Education Ani Lytics, Inc. 1720 200 Girard Street, Suite 200 25 years or more ToxExpo Exhibitor Gaithersburg, MD 20877 United States Tel: 301.921.0168 Fax: 301.977.0433 Email: [email protected] Website: anilyticsinc.com Ani Lytics, Inc. performs clinical chemistry and hematology testing exclusively in support of biomedical research. Methods development and validation are offered. All methods are specific and/or appropriate for the species being tested. All work is in compliance with the GLPs. Product Categories: Biomarkers, Clinical Chemistry/Laboratory Analysis, Endocrinology Research/Testing, GLP—Good Laboratory Practice Services, Preclinical Research/Testing Antech Diagnostics GLP 1304 600 Airport Boulevard, Suite 500 Morrisville, NC 27560 United States Tel: 919.277.0822 Fax: 919.277.0825 Email: [email protected] Website: www.antechglp.com Antech Diagnostics GLP is a clinical pathology laboratory that is fully compliant with the Good Laboratory Practice Regulations as set forth in 21 CFR Part 58 as well as other regulatory requirements. On-site QA and an exceptional focus on customer service allow us to meet your study deadlines. We offer analysis of veterinary specimens in hematology, urinalysis, special chemistry and immunoassays. We also perform testing for non-GLP and GCP studies. Product Categories: Clinical Chemistry/Laboratory Analysis, Clinical Pathology, Endocrinology Research/Testing, Hematology

Products and Services 365 days of the year—Visit ToxExpo.com 30 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo Follow us on Twitter at @SOToxicology and @ToxExpo 31 For up-to-date information use Tweet using #2015SOT and #toxexpo the SOT Mobile Event App or the Online Planner EXHIBITOR DESCRIPTIONS EXHIBITOR DESCRIPTIONS

Applied BioPhysics, Inc. 1005 185 Jordan Road Troy, NY 12180 United States Tel: 518.880.6860 Fax: 518.880.6865 Email: [email protected] Website: www.biophysics.com ECISTM (Electric Cell-Based Impedance Sensing) is a real-time, impedance-based method to study the behavior of cells grown in tissue culture. Assays include TEER, migration, proliferation, signal transduction, cell differentiation, phenotypic assays, cell toxicity, stem cell biology as well as cell behavior under dynamic flow conditions. The measurement is continuous and label free. Up to four 96 well plates can be run simultaneously without opening the incubator door. Product Categories: Biomedical Research Products, Instruments, Manufacturing-Custom, Microarrays Aptuit LLC 719 Two Greenwich Office Park 25 years or more ToxExpo Exhibitor Greenwich, CT 06831 United States Tel: 855.506.6360 Email: [email protected] Website: www.aptuit.com Aptuit is a pharmaceutical services company that delivers early to mid-phase drug development solutions by applying scientific excellence, a platform of exceptional technologies, and a team that combines the efficiency of a CRO with the scientific expertise of a R&D engine. Working as a highly integrated team, the Preclinical Safety group provides a wide spectrum of preclinical studies tailored to address your regulatory and investigative needs, including both standard and customized studies. Product Categories: Biotechnology Research/Testing, CRO—Contract Research Organization, Gene Expression, Regulatory Services/Toxicology, Safety Assessment Aquaneering, Inc. 1842 7960 Stromesa Ct. San Diego, CA 92126 United States Tel: 858.578.2028 Toll Free: 888.932.2782 Fax: 858.689.9326 Email: [email protected] Website: www.aquaneering.com Aquaneering is featuring recent product development solutions for Aquatic Housing Systems used in the rapidly growing area of toxicology studies with increased biosecurity requirements. The Leader in Aquatic Housing for Zebrafish, Xenopus, and other species used for medical research, AQUANEERING offers unmatched knowledge of highly advanced filtration technologies resulting in undetectable levels of ammonia and nitrites. Manufacturer of the largest Zebrafish systems in the world. Product Categories: Animal Equipment, Aquatic Sciences/Testing

Products and Services 365 days of the year—Visit ToxExpo.com 32 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo ePosters—A Convenient Way to View Posters Did you miss the opportunity to view a poster of interest? In addition to attending Poster Sessions, you can view some posters through the SOT Mobile Event App. • Search and view the ePosters on your mobile device using the ePoster feature in the SOT Mobile Event App—before, during, and after the meeting (until May 11, 2015). If you are a poster presenter, please take a few minutes to upload your PowerPoint or PDF poster through an Internet-based, user-friendly presentation system prior to the meeting at https://cms.psav.com/sot2015 or during the meeting in the Speaker Ready Room at the San Diego Convention Center, Room 11B.

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Arbor Assays 2145 1514 Eisenhower Place Please see our ad on page 33. Ann Arbor, MI 48108 United States Tel: 734.677.1774 Toll Free: 855.677.1774 Fax: 734.661.1884 Email: [email protected] Website: www.arborassays.com Arbor Assays specializes in the development of high sensitivity assay kits, high-purity inhibitors, and antibodies for drug discovery and basic research. Products for research in non-invasive endocrinology, mitochondrial dysfunction, oxidative stress, cell signaling biomarkers, kidney damage, cholinesterase activity, and other areas are readily available. We also offers custom assay development and testing services. We make unique kits to measure P450, AChE and BChE Activity. Product Categories: Antibody Products, Biomarkers, Immunology Equipment/Supplies, Reproductive Toxicology, Wildlife Testing ArunA Biomedical, Inc. 2237 425 River Road Athens, GA 30602 United States Tel: 706.542.9191 Fax: 706.262.2821 Email: [email protected] Website: www.arunabiomedical.com ArunA Biomedical designs, develops and manufactures biologically relevant products and services derived from human pluripotent stem cells. ArunA’s products satisfy a wide range of research applications in an easy-to-use monolayer format and are well suited for cellular assay and imaging systems. Because of the unique features of ArunA’s cells and a proprietary manufacturing system, the Company is able to provide reproducible human cellular models efficiently and cost effectively. Product Categories: Cells/Tissue, Developmental Toxicology, In Vitro Metabolism, Neurobiology/Neurotoxicology, Reproductive Toxicology Asterand Bioscience 1008 440 Burroughs Suite 501 Detroit, MI 48202 United States Tel: 313.263.0960 Email: [email protected] Website: www.stemgent.com Asterand Bioscience, a leading supplier of tissue-based research and cellular reprogramming products and services, provides researchers a comprehensive portfolio of tools for human cell research. These include human tissue, biofluids, cell lines, primary cells, and services supporting gene expression, protein localization, 2D and 3D cell-based assays and tissue cross-reactivity. Product Categories: Clinical Toxicology/Testing, Gene Expression, Preclinical Research/Testing, Tissue Equipment/Research/ Supplies

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Axiogenesis 903 600 W Germantown Pike, Suite 110 Plymouth Meeting, PA 19462 United States Tel: 844.511.6959 Email: [email protected] Website: www.axiogenesis.com Since 2000, Axiogenesis has been in business to capture the promise of stem cells to revolutionize the fields of drug discovery, safety/tox & life sciences research. Axiogenesis develops and commercializes stem cell-derived, in vitro-differentiated cell types, EXHIBITOR DESCRIPTIONS EXHIBITOR as well as drug development assays and disease models, to help researchers discover cures. Axiogenesis offers human iPSC-derived cardiomyocytes (Cor.4U®), peripheral neurons (Peri.4U™) and dopaminergic neurons (Dopa.4U™). Product Categories: Cardiology/Cardiotoxicology, Cells/Tissue, In Vitro Research/Testing, Pharmacology, Safety Assessment Axion Biosystems, Inc. 817 1819 Peachtree Road NE, Suite 350 Atlanta, GA 30309 United States Tel: 404.477.2557 Email: [email protected] Website: www.axionbiosystems.com Axion's Maestro platform elevates in vitro microelectrode array (MEA) technology to the high-throughput arena, offering 12- and 48- well recordings in standard microplate formats. Multiple non-invasive electrodes in each well directly measure electrical activity from intact networks of excitable cells. Axion’s technology provides a systems-level, label-free platform for high-throughput investigations in neurotoxicology, cardiac safety, in vitro disease modeling, and drug discovery. Product Categories: Biotechnology Products, Biotechnology Research/Testing, High-Throughput Test Systems, In Vitro Equipment/ Supplies, In Vitro Research/Testing BASF SE 2008 GV/TE - Z470 Ludwigshafen, 67056 Germany Tel: +49 621 60-41340 Email: [email protected] Website: www.basf.com BASF experimental toxicology and ecology with decades of experience offers a complete range of regulatory studies in the field of toxicology and ecology in accordance with the most stringent standards demanded by authorities globally. The studies are conducted in AAALAC-certified laboratories in compliance with OECD, EC, EPA, MHLW/METI, J/MAFF, FDA guidelines, current animal protection regulations, and Good Laboratory Practice (GLP), with a clear commitment to quality and continuous improvement. Product Categories: Agrochemical Product Safety/Toxicology, Chemical Product Safety/Toxicology, In Vivo Research/Testing, Inhalation Research/Testing, Reproductive Toxicology BASi (Bioanalytical Systems, Inc) 1200 2701 Kent Avenue 25 years or more ToxExpo Exhibitor West Lafayette, IN 47906 United States Tel: 765.586.7675 Email: [email protected] Website: www.BASInc.com BASi, a global contract research organization, has provided the pharmaceutical, biotech and chemical industries with high-quality preclinical, clinical, pharmaceutical and bioanalytical support for more than 40 years. Services include toxicology/pathology, carcinogenesis/oncology studies, reproductive studies, pharmacokinetics/toxicokinetics and comply with GLP, GMP and GCP regulations. BASi is known for its expertise, responsiveness, and exemplary regulatory record. Product Categories: Acute Toxicology Services/Testing, Chronic Toxicology, GLP—Good Laboratory Practice Services, In Vivo Research/Testing, Reproductive Toxicology

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Battelle 1727

505 King Avenue ♦ 2015 Diamond Level Supporter Columbus, OH 43201 25 years or more ToxExpo Exhibitor United States Tel: 800.201.2011 Website: www.battelle.org Battelle is the world’s largest, independent research and development organization, providing a full array of GLP-compliant, nonclinical services and efficacy testing of drugs, vaccines and biologics to pharmaceutical, biotech, agrochemical companies and government agencies. We are a pioneer in the field of inhalation technology, safety pharmacology, and toxicology, and provide critical therapies and solutions to improve healthcare worldwide. Product Categories: Agrochemical Product Safety/Toxicology, Efficacy Testing, GLP—Good Laboratory Practice Services, Pharmaceutical Product Safety/Toxicology, Virology Research/Testing BBD BIOPHENIX S.L. - BIOBIDE 313 Paseo Mikeletegi 56, bajo San Sebastian, 20009 Spain Tel: +34 943 309360 Fax: +34 943 309370 Email: [email protected] Website: www.biobide.es The unique CRO specialized in the zebrafish animal model that combines image analysis and automation to work under a GLP environment. The know-how and expertise developed by Biobide has been acquired by BBD BioPhenix to help companies in their R&D process decreasing time and cost for a better selection of candidates. We offer toxicity and efficacy assays, specialized in tailor made solutions based on already validated assays, with high expertise generating transgenic/mutant zebrafish lines. Product Categories: Behavioral Testing/Equipment, Cardiology/Cardiotoxicology, Ecology/Ecotoxicology Services, Reproductive Toxicology Bio Medic Data Systems, Inc. 1501

1 Silas Road 25 years or more ToxExpo Exhibitor Seaford, DE 19973 United States Tel: 302.628.4100 Toll Free: 800.526.2637 Fax: 302.628.4110 Email: [email protected] Website: www.bmds.com BioMedic Data Systems manufactures implantable electronic RFID transponders that register ID and/or temperature subcutaneously. Our readers scan the transponders, as well as collect data from peripherals; like scales and calipers. Our readers can work as stand- alone storage devices or connect to a computer, transferring data real time. Product Categories: Animal Identification, Biomedical Research Products, Data Acquisition, Electronics, Telemetry/Telepathology

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Bioculture (Mauritius) Ltd 1028 PO Box 420 Glenmoore, PA 19343 United States Tel: 484.599.1064 Fax: 230.626.2844 Email: [email protected] Website: www.bioculturemauritius.com Since 1984, Bioculture has been supplying naturally occurring BV, SRV, STLV SIV, SVV, and malaria free Macaca fascicularis to EXHIBITOR DESCRIPTIONS EXHIBITOR the biomedical researchers to improve the lives of people worldwide. Bioculture produces F1, F2, and F2+ purpose bred cynos in its AAALAC, Home Office, and ISO approved facilities in Mauritius. Our cynos are available in the UK, EU, US, and SE Asia. Ask us about Client customized cyno training and adaptation programs to reduce stress and speed the time to study post-arrival. Product Categories: Animal Models, Cells/Tissue, Primate Supplies/Testing, Tissue Equipment/Research/Supplies BioPorto Diagnostics A/S 907 Tuborg Havnevej 15, Street Hellerup, 2900 Denmark Tel: +45 45290000 Email: [email protected] Website: www.bioporto.com BioPorto Diagnostics focuses on the development of high-quality antibodies and biomarkers. Our solutions apply in all phases of pharmaceutical development. As a result of our dedicated focus on creation of innovative solutions for pharmaceutical development and basic research, we are able to offer a unique, early nephrotoxicity biomarker NGAL. Our market leading NGAL range includes NGAL measurements in rat, mouse, dog, pig, monkey and human. Further information at: www.ngal.com. Product Categories: Acute Toxicology Services/Testing, Antibody Products, Biomarkers, Biotechnology Products, Safety Assessment Biopredic International 608 5801 W 129th #101 Overland Park, KS 66209-3605 United States Tel: 913.530.5281 Fax: 913.685.1150 Email: [email protected] Website: www.biopredic.com Biopredic International develops and markets unique in vitro systems to test exogenous chemicals' toxicity risk, pharmacologic effect, target interaction, and effect on metabolism, excretion, and absorption. Our HepaRG human hepatic cells are a breakthrough for in vitro studies; reproducible and predictable, they demonstrate many mechanisms of toxicity; can be reliably infected with many viral agents; and have demonstrated utility in Liver Assist Devices and 3D bioreactors. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Cells/Tissue, Dermal Research/Testing, In Vitro Metabolism, Toxicogenomics

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Biopta Ltd 1234 Weipers Centre, Garscube Estate, Bearsden Road Glasgow, G61 1QH United Kingdom Tel: +44 0 141.330.3831 Fax: +44 0 141.330.2166 Email: [email protected] Website: www.biopta.com Biopta Ltd is the leading CRO focused on the use of fresh functional human tissues in drug development. Based in Glasgow, UK, Biopta has been providing services to the industry since 2002 establishing itself as the world leader in the use of fresh human tissue. Our core expertise is utilizing fresh human tissue and measuring a functional response such as constriction or dilation, or the release of markers. These assays can be applied to a wide range of both diseased and healthy tissues. Product Categories: Safety Assessment, Efficacy Testing, Nonclinical Research, Preclinical Research/Testing BioreclamationIVT 1300 1450 S Rolling Road 25 years or more ToxExpo Exhibitor Baltimore, MD 21227 United States Tel: 410.394.7600 Fax: 443.836.0340 Email: [email protected] Website: bioreclamationivt.com BioreclamationIVT is a worldwide provider of biological and in vitro products to pharmaceutical and biotechnology organizations. We specialize in control and disease state matrices manufactured from human and animal blood, plasma and serum. We provide large lots of hepatocytes, other cell types, and subcellular fractions. For inquiries email [email protected] or visit us at www.bioreclamationivt.com. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Biomedical Research Products, Cells/Tissue, In Vitro Metabolism, Preclinical Research/Testing BioReliance 1313 3050 Spruce Street 25 years or more ToxExpo Exhibitor St Louis, MO 63103 United States Tel: 314.771.5765 Fax: 314.286.7817 Email: [email protected] Website: www.bioreliance.com/toxicology.aspx BioReliance, a leader in contract services for product safety, is a specialized provider for all industries, focusing on dedicated and superior delivery of services. Our areas of expertise include a novel suite of in vitro ADME/Tox services; and comprehensive GeneTox resources, with screening and GLP assays, as well as paradigms to follow up positive results. We also are the leading provider of transgenic carcinogenicity assessment and cutting-edge R&D developing new and innovative assays. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Consumer Product Safety/Toxicology, In Vitro Metabolism, Metabolism Studies, Pharmaceutical Product Safety/Toxicology

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Biosearch Technologies, Inc. 2119 2199 So. McDowell Boulevard Petaluma, CA 94954-6904 United States Tel: 415.883.8400 Email: [email protected] Website: www.biosearchtech.com Biosearch Technologies offers sophisticated oligonucleotide-based tools for real-time PCR and Stellaris® RNA FISH. Stellaris RNA FISH makes use of multiple, singly-labeled oligonucleotides to enable localization and quantification of RNA at the single cell and EXHIBITOR DESCRIPTIONS EXHIBITOR molecule level. Scientists can visualize RNA in cells and tissue without purification, reverse transcription, or amplification. Product Categories: Biotechnology Products, Cells/Tissue, Chemical Synthesis, Gene Expression, Genomics Products, Genomics Research/Testing, Manufacturing-Custom, Medical Devices/Testing, Molecular Biology/Products/Synthesis, Synthesis BioSpyder Technologies 2233 2736 Loker Ave W, Suite B Carlsbad, CA 92010 United States Tel: 760.476.1800 Email: [email protected] Website: biospyder.com BioSpyder is developing and marketing a targeted sequencing technology for measuring gene expression, TempO-Seq™, which reduces the complexity of the sample submitted for sequencing, and thus cost per sample, while permitting large numbers of genes to be measured. While transformative throughout life science and diagnostic applications, BioSpyder is focused first on safety and high content screening and single cell assay, growth markets within the pharma industry. Product Categories: Biotechnology Products, Gene Expression, Genomics Products, High-Throughput Test Systems, In Vitro Research/Testing BioStat Consultants, Inc. 927 528 W Centre Avenue Portage, MI 49024 United States Tel: 269.329.7976 Fax: 810.626.0012 Email: [email protected] Website: www.biostat.net Experience, Expertise, and Excellence. BioSTAT’s contract statistical services are tailored to the specific needs of toxicology and drug discovery for both human and animal health, in the . Product Categories: Consulting Services, Pharmaceutical Product Safety/Toxicology, Quality Assurance, Statistical Analysis Services BioTox Sciences 1709 PO Box 910418 San Diego, CA 92191 United States Tel: 858.605.5882 Email: [email protected] Website: www.biotoxsciences.com BTS Research, based in San Diego, is a Contract Research Organization (CRO) offering comprehensive services for In Vitro and In Vivo preclinical studies in a state of the art AAALAC-accredited vivarium. Our services encompass toxicology, pharmacology, cancer and metabolism testing in Non-Human Primates, Dog, Pigs, Rabbits and Rodents. Product Categories: CRO—Contract Research Organization, Pharmaceutical Product Safety/Toxicology, Preclinical Research/ Testing, Regulatory Services/Toxicology

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BMG LABTECH 1944 13000 Weston Parkway, Suite 109 Cary, NC 27513 United States Tel: 877.264.5227 Fax: 919.678.1640 Email: [email protected] Website: www.bmglabtech.com BMG LABTECH—The Microplate Reader Company—offers a wide range of microplate readers for a multitude of applications in life science, drug discovery and research. No matter what your assay, BMG LABTECH offers multimode, dedicated and HTS microplate readers to fit your application needs. Product Categories: Analytical Instruments Bruker 1042 15 Fortune Drive Billerica, MA 01821 United States Tel: 978.667.9580 Email: [email protected] Website: www.bruker.com Our range of techniques includes resonance imaging (MRI), PET/MRI imaging, Optical Imaging, PET/SPECT/CT imaging, micro- CT and magnetic particle imaging (MPI) as well as MALDI Imaging. Product Categories: In Vivo Research/Testing, Instruments BSL BIOSERVICE Scientific Laboratories GmbH 837 Behringstr. 6/8 Planegg, 82152 Germany Tel: +49 89 899 650 0 Fax: +49 89 899 650 11 Email: [email protected] Website: www.bioservice.com BSL BIOSERVICE Scientific Laboratories GmbH is an internationally active CRO and preferred partner of Eurofins, a world leader in analytical testing. Our laboratories are part of a global scientific network offering services from discovery and preclinical testing to market approval. BSL BIOSERVICE has the proven experience, a wide range of services and the necessary expertise to initiate preclinical drug development by designing, performing and documenting biological safety and activity tests. Product Categories: Chemical Product Safety/Toxicology, Food Safety/Toxicology, In Vitro Research/Testing, Medical Devices/ Testing, Pharmaceutical Product Safety/Toxicology Calvert Laboratories, Inc. 918

130 Discovery Drive ★ 2015 Silver Level Supporter Scott Township, PA 18447 25 years or more ToxExpo Exhibitor United States Tel: 570.586.2411 Toll Free: 800.300.8114 Fax: 570.586.3450 Email: [email protected] Website: www.calvertlabs.com Calvert Labs is a collaborative preclinical CRO bringing extensive experience, an innovative, solutions-oriented approach and unsurpassed performance to your drug development program. We offer a range of lead identification and optimization services and a wide array of preclinical services in most therapeutic areas to meet your R&D needs, helping you navigate your GLP testing needs prior to advancing to clinical trials. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), CRO—Contract Research Organization, Pharmacology, Preclinical Research/Testing, Regulatory Services/Toxicology

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Cardno ChemRisk & Cardno 627 101 2nd Street, Suite 700 San Francisco, CA 94105 United States Tel: 415.618.3200 Fax: 415.896.2444 Email: [email protected] Website: www.chemrisk.com Cardno ChemRisk is a scientific consulting firm committed to helping clients around the globe improve the health and safety of their EXHIBITOR DESCRIPTIONS EXHIBITOR products, operations, workers, the public, and the environment. We are focused on providing sustainable solutions to critical issues, and to proactively prevent issues from occurring in the first place. Cardno ChemRisk leads the way in working with the government, industry, and academia to provide objective, science-based solutions to difficult challenges. Product Categories: Consulting Services, Consumer Product Safety/Toxicology, Environmental Health, Risk Assessment CARE Research LLC/Colorado Histo-Prep 721 6200 East County Road 56 25 years or more ToxExpo Exhibitor Fort Collins, CO 80524 United States Tel: 970.493.2660 Fax: 970.493.8834 Email: [email protected] Website: www.careresearchllc.com A preclinical research lab in full compliance with US FDA and EPA GLP per the auspices of the Animal Welfare Act in numerous species, viz. rodents, rabbits, guinea pigs, dogs, cats, pigs, sheep, poultry, horses, and cattle. Facilities include 24/7 security, enhanced data management, a surgery suite and C-ARM, with engineered ventilation to maximize efficiency and sterility. Our experienced personnel provide efficient project initiation, completion and flexible scheduling with rapid turnaround. Product Categories; CRO—Contract Research Organization, Histopathology, Pharmacokinetics, Preclinical Research/Testing, Reproductive Toxicology Carter2 Systems, Inc. 2118 PO Box 6206 Beaverton, OR 97007 United States Tel: 207.323.2154 Fax: 503.844.9508 Email: [email protected] Website: csimfg.com Carter2Systems, Inc. designs and manufactures custom cages, transport, enrichment and biocontainment equipment for laboratory animals including non-human primates, dogs, sheep, pigs, ferrets, rabbits and more. Product Categories: Animal Equipment, Caging, Manufacturing-Custom

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Cayman Chemical 1001 1180 East Ellsworth Road Ann Arbor, MI 48108 United States Tel: 734.971.3335 Toll Free: 800.364.9897 Fax: 734.971.3420 Email: [email protected] Website: www.CaymanChem.com Cayman Chemical specializes in the production and distribution of assay kits, high-purity biochemicals, antibodies, and enzymes for drug discovery and basic research. Products for research in mitochondrial dysfunction, oxidative stress, free radical biomarkers, stem cell biology, and other areas are readily available. Cayman also offers custom biochemical synthesis and assays services. Product Categories: Biomedical Research Products, Cancer Biology/Carcinogenicity, CRO—Contract Research Organization, Endocrinology Research/Testing CBSET, Inc. 809 500 Shire Way Lexington, MA 02421 United States Tel: 781.541.5586 Email: [email protected] Website: www.cbset.org CBSET provides GLP (Good Laboratory Practice) and non-GLP research services ranging from early product evaluation, through lead optimization and preclinical safety, to physician assessment and training. CBSET’s nearly 40,000 square foot state-of-the-art facility includes vivariums, surgical suites, SEM, metabolism and pharmacokinetics, histopathology/pathology suites and board- certified veterinarian pathologists on staff. Product Categories: GLP—Good Laboratory Practice Services, Histopathology, Medical Devices/Testing, Pathology, Preclinical Research/Testing CDC NCEH/ATSDR 1843 1600 Clifton Road NE MS F61 Atlanta, GA 30329 United States Phone: 770.488.0589 Fax: 770.488.3377 Website: www.cdc.gov Website: www.cdc.gov/nceh Website: www.atsdr.cdc.gov

The CDC's National Center for Environmental Health prevents and controls diseases and injuries; provides information on critical health issues; and promotes healthy living. The Agency for Toxic Substances and Disease Registry evaluates the health effects of exposure to hazardous substances at sites on the Environmental Protection Agency's National Priorities List and other sites when petitioned. Product Categories: Environmental Health, Government Organizations, Organizations

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Cedarlane 1031 1210 Turrentine Street Burlington, NC 27215 United States Tel: 336.513.5135 Toll Free: 800.721.1644 Fax: 336.513.5138 Email: [email protected] Website: www.cedarlanelabs.com EXHIBITOR DESCRIPTIONS EXHIBITOR CEDARLANE is a reagent company offering a myriad of biological, biochemicals and test kits. Providing products from a magnitude of suppliers, CEDARLANE is the gateway to reagents of the world. As a distributor and aggregator/consolidator, customers can take advantage of savings on shipping costs. Delivery is timely and all products are moved and stored at the appropriate temperatures. Product Categories: Antibody Products, Biomedical Research Products, Biotechnology Products, Hematology, Manufacturing- Custom CellSystems GmbH 1845 Langeler Ring 5 Troisdorf, 53842 Germany Tel: +49-2241-255150 Email: [email protected] Website: www.cellsystems.de CellSystems offers highly sophisticated cell culture products and produce OECD validated reconstructed human epidermis consisting of keratinocytes: epiCS and rhe consisting of keratinocytes plus melanocytes: epiCS-M. epiCS for skin corrosion (OECD Test Guideline 431), skin irritation (OECD TG 439), skin sensitization (under Validation), genotoxicity, phototoxicity, and research and efficacy testing. epiCS-M for pigmentation studies and depigmentation studies. We provide contract research and testing services. Product Categories: Cells/Tissue, CRO—Contract Research Organization, In Vitro Equipment/Supplies, In Vitro Research/Testing, Preclinical Research/Testing Cellular Dynamics International, Inc. 801 525 Science Drive, Suite 200 Madison, WI 53706 United States Tel: 608.310.5100 Fax: 608.310.5101 Email: [email protected] Website: www.cellulardynamics.com Cellular Dynamics International is the world’s largest producer of fully functional human cells derived from induced pluripotent stem (iPS) cells. Our iCell product lines provide industrialized quantities of pure, homogenous, terminally differentiated human cells enabling basic research, efficient drug discovery programs, and reliably predictive toxicity and efficacy screening through in vitro clinical trials. Product Categories: Biotechnology Research/Testing, Cells/Tissue, Efficacy Testing, In Vitro Research/Testing, Pharmacology

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Center for Drug Safety Evaluation and Research 2134 501, Haike Road, Pudong District Shanghai, 201203 China Tel: +86-21-20231-000-1322 Fax: +86-21-20231967 Email: [email protected] Website: www.cdser.simm.ac.cn Center for Drug Safety and Evaluation Research (CDSER) of the Shanghai Institute of Material Medica (SIMM), located in China, is an organization providing our customers high-quality nonclinical safety assessment and early-stage toxicity screening research services. SIMM is under China Academy of Science, and plays directing and guiding role in national pharmaceutical industry. CDSER has experienced and successfully supported Clinical Trial Application (CTA) for Western Pharmaceuticals. Product Categories: CRO—Contract Research Organization, Nonclinical Research, Preclinical Research/Testing, Safety Assessment Certara 1945 5520 Dillard Drive Cary, NC 27518 United States Tel: 919.852.4644 Email: [email protected] Website: www.certara.com Certara is the global biosimulation technology-enabled drug development and drug safety consulting company. Our customers include hundreds of biopharmaceutical companies around the globe, together with several regulatory agencies. Our solutions span the discovery, preclinical and clinical stages of drug development and enable data-driven decisions, leading to more precisely designed trials with a reduced risk of failure and improved subject safety. For more information, visit www.certara.com. Product Categories: Consulting Services, Modeling Products/Services, Pharmacokinetics, Regulatory Services/Toxicology, Software CH Technologies (USA), Inc. 1440 263 Center Avenue 25 years or more ToxExpo Exhibitor Westwood, NJ 07675 United States Tel: 201.417.9805 Fax: 201.666.8611 Email: [email protected] Website: www.chtechusa.com CH Technologies supplies complete systems for nose-only and whole body inhalation exposure. We provide aerosol generators, measurement/sampling devices and animal restraints with applications in industrial hygiene, environmental health, bio-defense, pharmacy and microbiology. Our equipment, service and expertise are recognized globally as being unsurpassed. Product Categories: Biomedical Research Products, Biomedical Research Services, Industrial Hygiene, Inhalation Equipment, Respiratory Toxicology

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ChanTest Corp. 901 14656 Neo Parkway Cleveland, OH 44128 United States Tel: 216.584.0502 Fax: 216.332.1706 Email: [email protected] Website: www.chantest.com With the world’s most complete library of human ion channel-expressing cell lines, ChanTest, a Charles River company, is a market EXHIBITOR DESCRIPTIONS EXHIBITOR leader in the early functional screens for profiling drug candidates or ranking within profiles during the drug-discovery process as well as associated in vitro safety testing. The addition of ChanTest to Charles River enhances the company’s existing portfolio allowing for further optimization of the drug development process. Please visit ChanTest at booth #1326. Product Categories: Bioanalytical Services, CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, Efficacy Testing, Preclinical Research/Testing, In Vitro Research/Testing, Safety Assessment Charles River 1326

251 Ballardvale Street ♦ 2015 Diamond Level Supporter Wilmington, MA 01887 ▲ SOT Affiliate United States Tel: 781.222.6000 25 years or more ToxExpo Exhibitor Fax: 978.988.9236 Please see our ad on inside front cover. Email: [email protected] Website: www.criver.com With a mission to deliver custom, flexible solutions, Charles River provides clients with exactly what they need to improve and expedite the development of new therapies. From discovery all the way through to clinical support, our scientific experts leverage an expansive safety assessment portfolio, a range of laboratory support services and global, state-of-the-art facilities to produce the quality data you need to optimize your drug development program, every step of the way. Product Categories: Acute Toxicology Services/Testing, ADME (Absorption/Distribution/Metabolism/Excretion), Agrochemical Product Safety/Toxicology, Animal Models, Animal Use & Welfare, Aquatic Sciences/Testing, Behavioral Testing/Equipment, Bioanalytical Services, Biochemistry, Biomarkers, Biotechnology Research/Testing, Bone Biology/Toxicology, Cancer Biology/ Carcinogenicity, Cardiology/Cardiotoxicology, Cells/Tissue, Chemical Product Safety/Toxicology, Chronic Toxicology, Clinical Chemistry/Laboratory Analysis, Clinical Pathology, Consumer Product Safety/Toxicology, Cosmetic Product Safety/Toxicology, CRO—Contract Research Organization, Dermal Research/Testing, Developmental Toxicology, Efficacy Testing, Endocrinology Research/Testing, Entomology/Parasitiology Services, Environmental Research/Services/Testing, Fish Toxicology, Genotoxicity Products/Services, GLP—Good Laboratory Practice Services, Histopathology, HPLC—High Pressure Liquid Chromatography, Immunology Research/Testing, In Vitro Metabolism, In Vitro Research/Testing, In Vivo Metabolism, In Vivo Research/Testing, Inhalation Research/Testing, LC/MS-Liquid Chromatography/Mass Spectroscopy, Metabolism Studies, Neonatal/Pediatric Studies, Neurobiology/Neurotoxicology, Nonclinical Research, Ophthalmic Research/Testing, Pathology, Product Safety/ Toxicology, Pharmaceutical Product Safety/Toxicology, Pharmacokinetics, Pharmacology, Photo-Biology/Toxicology Services/ Testing, Preclinical Research/Testing, Regulatory Services/Toxicology, Reproductive Toxicology, Respiratory Toxicology, Safety Assessment, Surgical Services, Telemetry/Telepathology, Toxicogenomics, Toxicokinetics, Transgenic Models, Veterinary Contract Laboratories

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Chemical Solutions Ltd. 1718 273 Mulberry Drive, Suite 9 Mechanicsburg, PA 17050 United States Tel: 717.697.7536 Fax: 717.697.4800 Email: [email protected] Website: www.chemicalsolutionsltd.com Chemical Solutions Ltd. (CSL) is a contract testing laboratory specializing in elemental analyses by ICP-MS. CSL is US FDA- registered and audited, NELAC- and ISO-accredited. The multiple elemental detection, precision, and accuracy benefits of ICP-MS, are suitable for research in the toxicology discipline. CSL has accumulated 17 years of experience in trace elemental analyses. We are able to provide quality data while having the flexibility of staying within your research budget. Stop by 1718! Product Categories: Biotechnology Research/Testing, Clinical Toxicology/Testing, Environmental Research/Services/Testing, GLP—Good Laboratory Practice Services, Metal Toxicology Chilworth Technology Ltd 1734 Southampton Science Park Southampton, Hampshire SO16 7NS United Kingdom Tel: +44(0) 23 8076 0722 Email: [email protected] Website: www.chilworth.co.uk Chilworth offers phys/chem and regulatory laboratory testing, consulting, training and instruments to manufacturing companies across a wealth of industries in over 40 countries. With extensive knowledge and experience in the process safety and regulatory fields (REACH, GHS, CLP, UN Transport, DOT) our staff and facilities ensure the service and data received is of the highest quality. With facilities in the USA, Europe, India and China, we’re local to your needs. Product Categories: Analytical Instruments, Consulting Services, GLP—Good Laboratory Practice Services, Risk Assessment, Safety Assessment CITI Program at University of Miami 734 1400 NW 10th Avenue, Suite 910 Miami, FL 33136 United States Tel: 305.243.7970 Email: [email protected] Website: www.citiprogram.org The Collaborative Institutional Training Initiative (CITI Program) at the University of Miami offers customizable, web-based research ethics training in Animal Care and Use, Biosafety and Biosecurity, Conflicts of Interest, Export Control, Good Clinical Practice, Human Subjects Research, Information Privacy and Security, and Responsible Conduct of Research. Learn more at www.citiprogram.org. Product Categories: Education

Products and Services 365 days of the year—Visit ToxExpo.com 46 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo Academy of Toxicological Sciences

What does it take to be a Fellow of the Academy of Toxicological Sciences?

Knowledge Involvement Leadership Experience

ATS Headquarters 1821 Michael Faraday Drive, Suite 300, Reston, VA 20190 Tel: 703.438.3103 • Website: www.acadtoxsci.org

Information and application forms can be found at: www.acadtoxsci.org

A Member of the International Union of Toxicology

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CiToxLAB 2327 445 Armand-Frappier Boulevard Laval, QC H7V 4B3 Canada Tel: +450.973.2240 Email: [email protected] Website: www.citoxlab.com CiToxLAB (with facilities in North America and Europe) offers a range of preclinical services to meet the needs of Pharma, Biotech and Chemical industries worldwide. Our services portfolio includes: Toxicology (general, reproductive, juvenile, infusion, inhalation, carcinogenicity, transgenics) and safety pharmacology (incl. EEGs). Other expertise includes: Drug discovery and DMPK, genotoxicology, toxicogenomics, bioanalysis, immunology, ecotoxicology, radiation safety (ARS), NHPs and minipigs. Product Categories: Agrochemical Product Safety/Toxicology, Cosmetic Product Safety/Toxicology, Genomics Research/Testing, In Vitro Research/Testing, In Vivo Research/Testing ClearH2O, Inc. 1043 117 Preble Street Portland, ME 04101 United States Tel: 207.221.0039 Toll Free: 888.493.7645 Fax: 207.774.3449 Email: [email protected] Website: www.clearh2o.com ClearH2O® offers barrier packed hydration, nutrition, enrichment and medication delivery products that enhance the wellness and survival of research animals. Our knowledge of taste preferences improves consumption. ClearH2O products help you protect your investment in research and results. HydroGel is the #1 choice for breeders for hydrating animals in transit. Product Categories: Animal Diets, Biotechnology Products, Diet Formulation, Primate Supplies/Testing Clever Sys Inc 1138 11425 Isaac Newton Square S Suite 202 Reston, VA 20190 United States Tel: 703.787.6946 Email: [email protected] Website: www.cleversysinc.com Clever Sys is a bioinformatics company specializing in automated behavioral testing, including data collection and analysis. Clever Sys, combines video tracking with patented behavior recognition technology to study behavior in animals as complex as humans and as simple as fruit flies. The applications of behavior recognition are broad, and CSI’s customers include biotech and medical researchers; pharmaceutical companies, military, and homeland security offices, and medical patient care centers. Product Categories: Behavioral Testing/Equipment, Biomedical Research Services, CRO—Contract Research Organization, High-Throughput Test Systems, Image Capture Devices

Products and Services 365 days of the year—Visit ToxExpo.com 48 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo EXHIBITOR DESCRIPTIONS

Comparative Biosciences (CBI) 737 786 Lucerne Drive Sunnyvale, CA 94085 United States Tel: 408.738.9260 Fax: 408.738.9278 Email: [email protected] Website: www.compbio.com CBI provides the best resources and quality service to all sectors of the biomedical community. With a multitude of expertise, we are EXHIBITOR DESCRIPTIONS EXHIBITOR able to serve pharmaceutical and biotech companies as well as academic, industrial and governmental organizations. CBI’s extensive experience performing GLP and non-GLP preclinical toxicology, efficacy, pharmacology, pharmacokinetics-pharmacodynamics, histopathology, and safety studies make us the ideal collaborator for your next scientific breakthrough. Product Categories: Acute Toxicology Services/Testing, Animal Models, CRO—Contract Research Organization, Dermal Research/ Testing, In Vivo Research/Testing CorDynamics 1206 2242 W. Harrison Street, Suite 108 Chicago, IL 60612 United States Tel: 312.421.8876 Toll Free: 877.644.3142 Fax: 312.873.3710 Email: [email protected] Website: www.cordynamics.com CorDynamics is the only CRO dedicated to answering your cardiovascular toxicology and safety pharmacology questions for your lead compound today rather than reacting tomorrow. Let us help you make good science decisions as well as good business decisions. Consider us your satellite cardiovascular lab and think tank. Investigating safety and disease models like heart failure, pulmonary arterial hypertension, atrial fibrillation, thrombosis and ischemia reperfusion is our specialty. Product Categories: Cardiology/Cardiotoxicology, CRO—Contract Research Organization, Preclinical Research/Testing, Safety Assessment, Telemetry/Telepathology Cosmo Bio USA, Inc. 831 2792 Loker Avenue West, Suite 101 Carlsbad, CA 92010 United States Tel: 760.431.4600 Fax: 760.431.4604 Email: [email protected] Cosmo Bio USA provides quality life science products from leading Japanese manufacturers to research laboratories throughout North America. We take pride in that our products fill a current need for hard to find reagents and instruments and are created under the meticulous care of Japanese scientists. Our products fall into many categories including antibodies, tissue culture, IHC, ELISA, molecular biology reagents, as well as a number of tools for cancer, stem cell, and neuroscience research. Product Categories: Antibody Products, Cancer Biology/Carcinogenicity, Cells/Tissue, Immunohistochemistry Research/Supplies, Molecular Biology/Products/Synthesis

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Covance Inc. 1601

3301 Kinsman Boulevard ▲ SOT Affiliate Madison, WI 53704 25 years or more ToxExpo Exhibitor United States Tel: 952.767.3628 Fax: 952.884.5680 Email: [email protected] Website: www.covance.com As one of the world’s largest and most comprehensive drug development service companies, we have helped pharmaceutical and biotech companies develop one-third of all prescription drugs in the marketplace today. Because of our broad experience and specialized expertise, we’re in a unique position to supply insights that go above and beyond testing. Together with our clients, we create solutions that transform potential into reality. Product Categories: Consulting Services, CRO—Contract Research Organization, Nonclinical Research, Preclinical Research/ Testing CRC Press—Taylor & Francis Group LLC 1626 6000 Broken Sound Parkway NW, Suite 300 25 years or more ToxExpo Exhibitor Boca Raton, FL 33487 United States Please see our ad on the inside back cover. Tel: 561.994.0555 Fax: 561.361.6018 Email: [email protected] Website: www.crcpress.com CRC Press, Taylor and Francis Group is a global publisher of print and electronic books and journals for the medical, scientific, and technical communities. Visit our booth to browse our new and bestselling publications in toxicology and to take advantage of convention discounts of up to 25%. For a complete catalog of all of our toxicology publications and forthcoming titles, or to sign up for our email list to receive exclusive offers, please visit our website today. Product Categories: Publishers Critical Path Institute 743 1730 E. River Road Tucson, AZ 85718 United States Tel: 520.382.1377 Email: [email protected] Website: www.c-path.org The Predictive Safety Testing Consortium (PSTC) is a unique public private partnership that brings together pharmaceutical companies to share and validate each other’s safety testing methods in cooperation with the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), and the Japanese Pharmaceuticals and Medical Devices Agency (PMDA). PSTC is one of seven consortia comprising the Critical Path Institute (C-Path), a nonprofit organization. Product Categories: Biomarkers, Regulatory Services/Toxicology, Research

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CTEH® 1136 5120 North Shore Drive North Little Rock, AR 72118 United States Tel: 501.801.8500 Fax: 501.801.8501 Email: [email protected] Website: www.cteh.com Center for Toxicology and Environmental Health, L.L.C., CTEH is a science-based environmental consulting firm established to EXHIBITOR DESCRIPTIONS EXHIBITOR provide toxicology and human health consulting services to the public and private sectors. We pride ourselves on providing highly technical and responsive professionals to evaluate and develop solutions to a wide variety of health and environmental issues. CTEH specializes in toxicology, risk assessment, industrial hygiene, occupational health, and emergency response. Product Categories: Chemical Product Safety/Toxicology, Consulting Services, Environmental Health, Industrial Hygiene CXR Biosciences Limited 1715 2 James Lindsay Place, Dundee Technopole Dundee, Tayside DD1 5JJ United Kingdom Tel: +44 1382 432163 Fax: +44 1382 432153 Email: [email protected] Website: www.cxrbiosciences.com CXR Biosciences is a unique CRO providing innovative mechanism-based approaches to improve compound development or resolve unexpected toxicity issues. We are experts in investigative toxicology and ADME with emphasis on the prediction of animal to human data and work with numerous pharma, agrochemical, petrochemical, and food and consumer product companies. Our portfolio includes in vitro and in vivo toxicology biomarkers, screening and investigative toxicology protocols, for chemicals and nanomaterials. Product Categories: Chemical Product Safety/Toxicology, Mechanistic Research/Testing, Microarrays, Pesticide Product Safety/ Toxicology, Preclinical Research/Testing Cyprotex 1733 313 Pleasant Street Watertown, MA 02472 United States Tel: 617.600.4300 Email: [email protected] Website: www.cyprotex.com Cyprotex is an AIM-listed company (CRX) headquartered in Macclesfield, UK with laboratories in Watertown, MA and Kalamazoo, MI (CeeTox). The company is the leader in predictive toxicology and ADME research, offers several proprietary technologies (CellCiphr® Premier. eCiphr®Cardio and eCiphr®Neuro) and prides itself on custom assay development and fast turnaround times. Product Categories: CRO—Contract Research Organization

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Data Sciences International (DSI) 1918 119 14th Street NW 25 years or more ToxExpo Exhibitor St. Paul, MN 55112 United States Tel: 651.481.7400 Toll Free: 800.262.9687 Fax: 651.481.7417 Email: [email protected] Website: www.datasci.com DSI offers preclinical physiological monitoring solutions for respiratory, CV, and CNS applications involving acute or chronic studies. Products include data collection and analysis systems coupled with hardwired amplifiers, implantable telemetry, and JET external telemetry. New offerings include smaller telemetry implants, jacketed telemetry with BP, automated analysis, respiratory chambers, and implantable infusion pumps. Offices throughout Europe, USA, and Asia provide support and expertise. Product Categories: Blood Pressure Accessories, Data Acquisition, Data Reporting Systems, Surgical Services, Telemetry/ Telepathology Datacolor Inc. 1816

5 Princess Road ★ 2015 Contributor Level Supporter Lawrenceville, NJ 08648 United States Tel: 610.704.7272 Email: [email protected] Website: www.scientific.datacolor.com/products Get consistent, report-quality images with scientific integrity, fast! Datacolor brings you CHROMACAL™, an innovative color calibration solution for brightfield microscopy. A first-of-its-kind system, CHROMACAL ensures consistent color in digital microscopy images to ensure a reliable basis for evaluation, communication, and documentation. CHROMACAL performs both image and monitor calibration for color consistency throughout the imaging process. See CHROMACAL for yourself in BOOTH #1816. Product Categories: Histopathology, Image Capture Devices, Immunohistochemistry Research/Supplies, Instruments, Photo-Biology/Toxicology Services/Testing Datamars, Inc. 613 250 West Cummings Park Woburn, MA 01801 United States Tel: 781.281.2216 Fax: 781.300.7330 Email: [email protected] Website: www.datamars.com Datamars is the global leader for high-performance RFID solutions in the animal identification market. Our expertise, innovation record and profound understanding of customers’ needs have earned Datamars a reputation for unsurpassed quality and performance. Datamars employs more than 600 employees worldwide. Datamars is a private company, headquartered in Bedano, Switzerland. For more information, visit datamars.com. Product Categories: Animal Equipment, Animal Identification, Data Management, In Vivo Equipment/Supplies

Products and Services 365 days of the year—Visit ToxExpo.com 52 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo EXHIBITOR DESCRIPTIONS

Dermal Technology Laboratory Ltd 1637 Med IC4, Keele University Science and Business Park Keele, Staffordshire ST5 5NL United Kingdom Tel: +44 1782 443043 Fax: +44 1782 443050 Email: [email protected] Website: www.dermaltechnology.com Dermal Technology Laboratory, based in the UK, conducts in vitro dermal absorption studies as part of the risk assessment process for chemicals and formulated products used by the crop protection, personal care and industrial chemical sectors. DTL also DESCRIPTIONS EXHIBITOR undertakes investigations on the skin absorption and distribution of pharmaceutical compounds into and through human skin. This includes the design of novel formulations in order to optimise the dermal delivery of bioactive compounds. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Agrochemical Product Safety/Toxicology, Dermal Research/Testing, In Vitro Research/Testing, Product Registration Detroit R & D, Inc. 821 2727 Second Avenue, Suite 4113 Detroit, MI 48201 United States Tel: 313.961.1606 Fax: 313.963.7130 Email: [email protected] Website: www.detroitrandd.com Detroit R&D specializes in the research and development of diagnostic tools for biomarkers of hypertension, stress, cancer and environmental health. We provide P450-, lipoxygenase- and epoxide hydrolase-dependent ELISAs (14,15- and 11,12-DHET, 20- HETE, 12-HETE, 15-HETE), an oxidative stress (8-isoprostane) ELISA, the GDF-15 (MIC-1) prostate cancer ELISA, Bisphenol A ELISA, antibodies for drug-metabolizing enzymes and phosphorylated proteins and a mitochondrial DNA damage analysis kit. Product Categories: Antibody Products, Biomarkers, In Vitro Research/Testing, Preclinical Research/Testing DiaPharma Group, Inc. 1938 8948 Beckett Road West Chester, OH 45069 United States Tel: 513.860.9324 Email: [email protected] Website: www.diapharma.com The dead cells still count for DILI (Booth 1938). Visit DiaPharma to discuss cytokeratin 18 biomarkers for hepatotoxicity prediction (research use only). The M30 Apoptosense® ELISA detects hepatocyte apoptosis in the blood while M65®/M65 Epideath® ELISAs detect both apoptosis and necrosis, irrespective of whether caused by drugs, toxins, or disease. Product Categories: Biomedical Research Products, In Vitro Research/Testing, Research

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DiscoveRx 2316 42501 Albrae Street, Suite D Fremont, CA 94538 United States Tel: 650.279.7013 Toll Free: 866.448.4864 Email: [email protected] Website: www.kinomescan.com DiscoveRx® offers a comprehensive portfolio of innovative solutions for GPCRs, Kinases, NHRs, and now BioSeek®’s proprietary BioMAP® primary cell phenotypic profiling platform to support discovery efforts at all stages of discovery and development. From lead discovery and optimization to preclinical and beyond, DiscoveRx provides an integrated suite of solutions to identify off-target interactions with potential safety liability, accelerate development and maximize program success. Product Categories: Biotechnology Products, CRO—Contract Research Organization, In Vitro Research/Testing, Preclinical Research/Testing, Safety Assessment DMT-USA Inc. 521 525 Avis Drive, Suite 10 Ann Arbor, MI 48108 United States Tel: 734.355.1877 Email: [email protected] Website: www.dmt-usa.com DMT is a life science company with more than thirty years of experience in development, manufacturing and sales of hardware and software for ex-vivo studies in physiology, pharmacology and toxicology. We provide the needs of the user with high-level mechanical, electrical and software engineering expertise to become one of the world's leading designers and manufacturer of Wire, Pressure and Muscle Strip Myographs as well as Tissue Organ Bath Systems. Product Categories: Data Acquisition, In Vivo Research/Testing, Pharmacology, Pulmonary Equipment/Research, Tissue Equipment/Research/Supplies Douglas Connect GmbH 617 Baermeggenweg 14 Zeiningen, 4314 Switzerland Tel: +41 61 851 01 70 Email: [email protected] Website: www.douglasconnect.com Douglas Connect are European leaders in toxicology infrastructure providing secure cloud-based web services, data warehousing, research and analysis services and regulatory consulting. We coordinate a collaboration pool of partners allowing us to source the best competencies and resources required for each project. We lead the development of OpenTox as the leading global open framework for predictive toxicology and ToxBank as an international consultancy and infrastructure. Product Categories: Data Management, Regulatory Services/Toxicology, Safety Assessment, Software, Toxicokinetics

Products and Services 365 days of the year—Visit ToxExpo.com 54 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo EXHIBITOR DESCRIPTIONS

DV Biologics 1402 1239 Victoria Street Costa Mesa, CA 92627 United States Tel: 951.312.2751 Fax: 877.773.5959 Email: [email protected] Website: www.dvbiologics.com DV Biologics is a trusted global supplier of human biological tools for researchers and biopharmaceutical companies with the highest EXHIBITOR DESCRIPTIONS EXHIBITOR quality human-derived primary cells, media, and genomics/proteomics tools for toxicology, assay, and tissue engineering for drug discovery and development- including experimental controls, disease marker discover, and absorption assays. Our portfolio contains 600 products such as: CDNA, RNA, lysate, tissue blocks, stem cells and primary cells (diseased and normal). Product Categories: Acute Toxicology Services/Testing, ADME (Absorption/Distribution/Metabolism/Excretion), Cardiology/ Cardiotoxicology, Cells/Tissue, In Vitro Research/Testing Dynex Technologies 931 14340 Sullyfield Circle Chantilly, VA 20151 United States Tel: 703.631.7800 Toll Free: 800.288.2354 Email: [email protected] Website: www.dynextechnologies.com Dynex™, the leader in automated microplate processing has been delivering innovative ELISA instrumentation for over 40 years to meet the demands of clinical and life science labs including the fully automated DSX®, DS2®, and the breakthrough Agility® High-Throughput ELISA system. See the New Multiplier Flex™ powered by M2® Multiplexed microwell technology—the superior platform for assay development in multiplex format. Product Categories: Clinical Toxicology/Testing, High-Throughput Test Systems, Immunology Equipment/Supplies, Immunology Research/Testing, Microarrays eBioscience, An Affymetrix Company 832 10255 Science Center Drive San Diego, CA 92121 United States Tel: 888.999.1371 Toll Free: 888.999.1371 Fax: 858.642.2046 Email: [email protected] Website: www.ebioscience.com eBioscience, an Affymetrix company, develops and manufactures over 11,000 antibodies, proteins, immunoassays and multiplex assays at ISO-certified facilities worldwide. Focused on accelerating scientific discovery in immunology and oncology, we provide innovative solutions to researchers and clinicians looking to answer questions driving today's life science communities. Partner with the industry leader of translational science. Product Categories: Antibody Products, Biomarkers, Gene Expression, Immunohistochemistry Research/Supplies, Immunology Research/Testing

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ECGVET, LLC 1100 PO Box 613 Kingston, NJ 08528 United States Tel: 732.766.5755 Email: [email protected] Website: www.anilab.com ECGVET provides expert electrocardiographic evaluations for toxicology and safety pharmacology studies. ECGVET also provides blood pressure data evaluation, including High-Definition Oscillometry (HDO) data evaluation. In addition, preclinical studies utilizing, but not limited to, dogs, non-human primates or minipigs are offered through BWEF, Inc. Animal boarding and sales are also offered through BWEF, Inc. Product Categories: Cardiology/Cardiotoxicology, Consulting Services, Veterinary Consulting/Services Ellegaard Göttingen Minipigs A/S 1012 Soroe Landevej 302 Dalmose Denmark Tel: +45 20 27 46 80 Fax: +45 5818 5880 Email: [email protected] Website: www.minipigs.com Ellegaard Göttingen Minipigs is the exclusive breeder of genetically well-defined Göttingen Minipigs and has supplied the scientific community for more than thirty years. The company has been AAALAC-accredited since 1998 and has high standard of minipig health. Göttingen Minipigs are fully accepted by the regulatory authorities such as EMA and FDA and should always be considered when choosing your non-rodent model for pharmacology or toxicology. Clean pigs for clear results. Product Categories: Animal Husbandry, Animal Models, Animal Use & Welfare Elm Hill Breeding Labs, Inc. 2027 7 Kidder Road Chelmsford, MA 01824 United States Tel: 978.256.2322 Toll Free: 800.941.4349 Fax: 978.256.2545 Email: [email protected] Website: www.elmhilllabs.com Elm Hill Labs is the largest producer of virus-antibody-free guinea pigs exclusively in the United States. Elm Hill Labs has been raising guinea pigs for the research community for over 50 years, and is known as “The Guinea Pig Specialist.” Product Categories: Animal Husbandry, Animal Models Elsevier 1406

360 Park Ave South 25 years or more ToxExpo Exhibitor New York, NY 10010 United States Tel: 631.665.1833 Email: [email protected] Website: www.elsevier.com Explore Elsevier’s high-impact toxicology content. Learn the latest in research news from journals such as Toxicology & Applied Pharmacology, and our new open access journal, Toxicology Report. Our exciting books on display include Handbook of Toxicology of Chemical Warfare Agents and many others. Discover our highly regarded electronic research and solution tools! Product Categories: Publishers

Products and Services 365 days of the year—Visit ToxExpo.com 56 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo SOT Pavilion Your Place to Connect at the Annual Meeting

Located in the ToxExpo Exhibit Hall, the SOT Pavilion is your place to connect and learn about SOT programs, services, membership benefi ts, and more. Find out about the SOT Endowment Fund, Toxicological Sciences, SOT awards, supported awards and fellowships, ToXchange—the SOT member network, educational programs from K–12 through the toxicology career, and everything taking place at the Annual Meeting. The SOT Pavilion is your place on the exhibit fl oor for all you want to learn about SOT and more. It’s a great place to connect, network, and discover what’s new. The SOT Pavilion is Booth 526 inside the Exhibit Hall. Find out how you can: • Apply to Join SOT or Check • Learn about the Wide on Member Status Variety of SOT’s Online • Participate in Your SOT Resources Regional Chapter, Special • Actively Participate in Interest Group, and/or ToXchange, the Private Specialty Section and Secure SOT Member • Connect through the SOT Network Website • Nominate and/or Apply for • Utilize the SOT Job Bank SOT Awards • Get one-on-one SOT Mobile Event App and Online Planner Assistance

SOT component group (Regional Chapters, Special Interest Groups, and Specialty Sections) and Global Gallery of Toxicology posters will be on display each day throughout ToxExpo hours. Stop by for a special “Representative Attended” poster session from 11:45 am–12:15 pm on Monday, March 23. “Meet the Leaders” each day from 3:00 pm–4:00 pm and learn more about the component groups within the Society of Toxicology.

Come see the High School Poster Exposition across from the SOT Pavilion from 10:30 am–12:30 pm on Tuesday, March 24. Meet with Toxicological Sciences Editors Monday–Wednesday

Gary W. Miller, Editor-in-Chief 10:00 am–11:00 am and 2:00 pm–3:00 pm

Virginia Hawkins, Managing Editor 9:00 am–4:00 pm (Look for signage on-site for more information)

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EMD Millipore Corporation 408 290 Concord Road Billerica, MA 01821 United States Tel: 800.645.5476 Fax: 800.304.1985 Email: [email protected] Website: www.millipore.com EMD Millipore is the Life Science division of Merck KGaA, Germany. We provide small molecules, transdermal diffusion models, water purification systems, analysis platforms for cellular, protein and nucleic acid toxicity biomarkers, and cell lines for hepatotoxicity. Our products and services provide testing for toxicity, TK/PK and immunogenicity, facilitating complete workflow solutions. Product Categories: Biotechnology Research/Testing, HPLC- High Pressure Liquid Chromatography, Immunohistochemistry Research/Supplies, Molecular Biology/Products/Synthesis, Research emka TECHNOLOGIES, INC. 2018 307 Annandale Road, Suite 203 Falls Church, VA 22042 United States Tel: 703.237.9001 Fax: 703.237.9006 Email: [email protected] Website: www.emkatech.com Together, emka TECHNOLOGIES and SCIREQ offer globally integrated solutions for physiology, pharmacology, and toxicology research. We provide a complete range of innovative instruments and services for in vivo and in vitro research. Our biomedical hardware and software combine accuracy and reproducibility to provide unparalleled insight into cardiovascular, respiratory and neurology studies, as cited in over 1,000 scientific publications. Visit our booth to discuss your research application! Product Categories: Behavioral Testing/Equipment, Cardiology/Cardiotoxicology, Cells/Tissue, In Vitro Equipment/Supplies, In Vivo Equipment/Supplies, Neurobiology/Neurotoxicology, Telemetry/Telepathology, Tissue Equipment/Research/Supplies Environ International Corp. 1345 1900 N. 18th Street, Suite 804 Monroe, LA 71201 United States Tel: 318.547.2429 Fax: 318.325.4889 Email: [email protected] Website: www.environcorp.com ENVIRON works with clients around the world to help resolve their most demanding environmental and human health issues. We combine resources across geographic boundaries and scientific disciplines to provide clients with the best, most responsive teams. ENVIRON’s preeminent skills in health sciences, exposure assessment and chemical transport help guide efforts to address the increasingly complex challenges related to protecting human health in occupational, consumer, and environmental settings. Product Categories: Consulting Services, Consumer Product Safety/Toxicology, Environmental Health, Epidemiology Services, Risk Assessment

Products and Services 365 days of the year—Visit ToxExpo.com 58 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo Follow us on Twitter at @SOToxicology and @ToxExpo 59 For up-to-date information use Tweet using #2015SOT and #toxexpo the SOT Mobile Event App or the Online Planner EXHIBITOR DESCRIPTIONS EXHIBITOR DESCRIPTIONS

Environmental Health Perspectives (EHP) 2127, 2129 PO Box 12233, K3-01 Research Triangle Park, NC 27709 United States Tel: 919.541.4561 Fax: 919.541.0273 Email: [email protected] Website: www.ehp.niehs.nih.gov Environmental Health Perspectives (EHP), published by the National Institute of Environmental Health Sciences, provides peer- reviewed research and news on the effect of the environment on human health. With an impact factor of 7.03, EHP is one of the top monthly journals in public, environmental, and occupational health. Product Categories: Endocrinology Research/Testing, Environmental Health, Exposure Assessment, Reproductive Toxicology, Toxicogenomics Enzo Life Sciences 1045 10 Executive Boulevard Farmingdale, NY 11735 United States Tel: 631.694.7070 Fax: 610.941.9252 Email: [email protected] Website: www.enzolifesciences.com The Enzo Life Sciences technical platform focus includes genomics, molecular biology, immunology, immunoassays, proteostasis, epigenetics, drug screening, and small molecule chemistry. Our product portfolio of fluorescent labels and dyes, ELISAs, enzyme activity assays, biochemicals, antibodies, and proteins serves the life sciences research, drug discovery and development, and clinical research markets. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Biochemistry, Chemical Product Safety/Toxicology, High-Throughput Test Systems EPISKIN 633 4 rue Alexander Fleming LYON, 69007 France Tel: +043 728 2200 Email: [email protected] Website: www.episkin.com EPISKIN, world leader in tissue engineering, is partnering with industries to develop relevant and reliable safety and efficacy tests for decision making during research and development phases. Some screening tests are already OECD validated as alternatives to animal use, and others are in the process of validation. For more than 23 years EPISKIN is committed to mass produce 52 weeks per year 3D models that exceed market expectations in term of performance, reliability and simplicity. Product Categories: Dermal Research/Testing, Efficacy Testing, In Vitro Research/Testing, Ophthalmic Research/Testing, Regulatory Services/Toxicology

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Epithelix 1244 14, chemin des aulx Plan-les-Ouates, Geneva CH-1228 Switzerland Tel: +41(0)22 794 65 15 Fax: +41(0)22 794 65 17 Email: [email protected] Website: www.epithelix.com Epithelix is a leader for in vitro inhalation toxicology assessment. Epithelix provides worldwide unique and robust 3D in vitro human EXHIBITOR DESCRIPTIONS EXHIBITOR respiratory tissues (MucilAir) which can be kept in culture for more than 1 year, allowing long-term and/or repeated toxicity testing in vitro. Epithelix also offers a panel of innovative in vitro testing services tailored to meet the specific needs of its customers in chemical, cosmetic, and pharmaceutical industry. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Cancer Biology/Carcinogenicity, Cells/Tissue, CRO—Contract Research Organization, In Vitro Equipment/Supplies, In Vitro Research/Testing, Inhalation Research/Testing, Metal Toxicology, Pharmaceutical Product Safety/Toxicology, Preclinical Research/Testing, Pulmonary Equipment/Research, Preclinical Research/Testing, Pulmonary Equipment/Research, Respiratory Toxicology, Toxicokinetics EPL Archives, Inc. 1617 45610 Terminal Drive Sterling, VA 20166 United States Tel: 703.435.8780 Fax: 703.435.1330 Email: [email protected] Website: www.eplarchives.com EPL Archives, a leader in the archive/biorepository field, provides secure GLP, GCP, GMP archival of research materials. EPL Archives provides secure preservation of research materials, including the fields of discovery, preclinical, clinical and manufacturing. EPL Archives' facilities, located in USA and France, provide in excess of 1,000,000 cubic feet of secure space, as well as the capacity to archive several hundred cryo freezers, creating one of the largest biorepositories in the world. Product Categories: Archiving/GLP Compliant Archiving, Data Management, GLP—Good Laboratory Practice Services, Storage/ Biorepository Services EPL, Inc. 1619 PO Box 169 25 years or more ToxExpo Exhibitor Sterling, VA 20167 United States Please see our ad on page 57. Tel: 703.471.7060 Fax: 703.471.8447 Email: [email protected] Website: www.epl-inc.com Experimental Pathology Laboratories, Inc. (EPL) is the world’s largest independent provider of GLP-compliant toxicologic pathology services. Since 1971, EPL has provided necropsy and histology support, pathology evaluation and consultation including pathology peer review and organizing Pathology Working Groups (PWG) for industry and government clients. We are able to customize our services to meet our clients’ specific scientific, regulatory and management objectives. Product Categories: Histopathology, Pathology, Archiving/GLP Compliant Archiving, Consulting Services

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Eurofins Pharma Discovery Services 1319 15318 NE 95th Street Redmond, WA 98052 United States Tel: 425.895.8666 Fax: 425.895.8668 Email: [email protected] Website: www.cerep.com With facility sites all around the world (France, Scotland, USA and Taiwan), Eurofins Pharma Discovery Services provides you the largest portfolio of pharmacology assays: in vitro pharmacology and ADME; in vivo models (pharmacology and safety); in vitro cellular models for immunology, oncology and functional toxicology. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), In Vitro Research/Testing, In Vivo Research/Testing, Preclinical Research/Testing EUROTOX 2015 636

c/o K.I.T. Group GmbH Dresden, Muenzgasse 2, 01067 Dresden, Germany ★ 2015 Gold Level Supporter Porto Portugal Please see our ad on page 59. Tel: +49 351 4967 541 Fax: +49 351 4956 116 Email: [email protected] Website: www.eurotox2015.org Welcome to Porto! The Portuguese Society of Pharmacology is proud to host EUROTOX 2015 in Portugal. Featuring in the UNESCO's World Heritage list since 1996, Porto is renowned for its natural and cultural attractions, gastronomy and the famous Port wines. EUROTOX attendants from all over the world will have the opportunity to establish and reinforce scientific networks, share the advancements in Toxicology and experience Portuguese hospitality. Visit us at booth no. 636 and convince yourself! Product Categories: Biomarkers, Clinical Toxicology/Testing, Food Safety/Toxicology, Metal Toxicology, Pharmacology Exemplar Genetics 1013 PO Box 198 Sioux Center, IA 51250 United States Tel: 712.722.2767 Fax: 712.722.2126 Email: [email protected] Website: www.exemplargenetics.com Exemplar Genetics is pioneering the development of large animal models for research in human diseases. Our patented technology enables us to efficiently target known genes associated with human diseases. Our ExeGen miniswine models mimic human disease phenotype enhancing your preclinical efficacy studies. ExeGen Miniswine models include: cardiovascular, hypercholesterolemia, atherosclerosis, cystic fibrosis, cardiac arrhythmia, cancer, muscular dystrophy, neuromuscular, and rare diseases. Product Categories: Animal Models, Gene Expression, In Vivo Research/Testing, Research

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Exiqon, Inc 317 12 Gill Street, Suite 1650 Woburn, MA 01801 United States Tel: 888.647.2879 Fax: 781.376.4152 Email: [email protected] Website: www.exiqon.com Researchers in academia, biotech, and pharma industries are using our products to make groundbreaking discoveries. We focus on EXHIBITOR DESCRIPTIONS EXHIBITOR collaborations that apply microRNA as biological markers in clinical research and clinical validation to reduce the time and cost of clinical trials, reduce adverse drug reactions and optimize therapies for patients’ needs. The unique value proposition of Exiqon is our ability to leverage potential of microRNAs as a novel group of biomarkers with our proprietary LNA detection technology. Product Categories: Biomarkers, Gene Expression, In Vitro Research/Testing, In Vivo Research/Testing, Microarrays Experimur 1915 4045 S. Morgan Street Chicago, IL 60609 United States Tel: 773.254.2700-232 Fax: 773.254.2723 Email: [email protected] Website: www.Experimur.com Experimur is a full-service CRO with extensive capabilities in the conduct of preclinical toxicology studies. Place your programs with Experimur and experience the superiority of a team skilled with decades of expertise, top quality and unmatched service. We invite you to our spectacular AAALAC-Accredited, USDA-registered, 54,000 sq. ft. state-of-the-art facility and vivarium, which includes extensive in-house support services for histology, pathology, clinical pathology and analytical chemistry. Product Categories: Chronic Toxicology, CRO—Contract Research Organization, Developmental Toxicology, Ophthalmic Research/Testing, Preclinical Research/Testing Exponent, Inc. 1306 149 Commonwealth Drive Menlo Park, CA 94025 United States Tel: 650.688.6951 Toll Free: 888.656.3976 Fax: 650.688.7077 Email: [email protected] Website: www.exponent.com Solving complex health problems requires an experienced, multidisciplinary team of professionals. Exponent’s Health Sciences Group includes toxicologists, epidemiologists, board-certified physicians, health economists, industrial hygienists, and statisticians. Centers of Excellence Include: Toxicology and Mechanistic Biology, Epidemiology and Biostatistics, Exposure Assessment and Dose Reconstruction, Occupational Medicine and Industrial Hygiene, Chemical Regulation and Food Safety, 20 US and 5 International Offices. Product Categories: Consulting Services, Epidemiology Services, Exposure Assessment, Food Safety/Toxicology, Risk Assessment

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ExPub (Expert Publishing) 1909 10 Estes Street Ipswich, MA 01938 United States Tel: 303.504.6390 Email: [email protected] Website: www.expub.com ExPub is the premier provider of up-to date decision-support chemical hazard information for EH&S professionals. With one simple search, ExPub gives you access to the world’s largest collection of its kind, including hard-to-find content from IARC, WHO, the National Toxicology Program, and other highly-regarded sources from around the globe. Call us today for your Free Trial and see why EH and S professionals stay up to date with chemical hazard information from ExPub. Product Categories: Literature Searches, MSDS (Material Safety Data Sheets) Management, Publishers, Risk Assessment FlowMetric 828 3805 Old Easton Road Doylestown, PA 18902 United States Tel: 267.893.6630 Fax: 267.893.6623 Email: [email protected] Website: www.flowmetric.com FlowMetric Inc is a specialized CRO partner providing state-of-the-art polychromatic flow cytometry experimental design, execution, analysis and aseptic cell sorting services. FlowMetric Inc provides preclinical through clinical development flow cytometry services in a GLP certified environment. We specialize in meeting client critical needs in an ever demanding context of decreased timelines and costs available for drug development. Product Categories: Biomarkers, Cells/Tissue, CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, High-Throughput Test Systems, Immunology Research/Testing, In Vitro Research/Testing, Nonclinical Research, Preclinical Research/Testing, Storage/Biorepository Services Fraunhofer ITEM 928 Nikolai-Fuchs Strasse 1 Hannover, 30625 Germany Tel: +49 511 5350 462 Fax: +49 511 5350 155 Email: [email protected] Website: www.item.fraunhofer.de At the Fraunhofer ITEM, expertise in various disciplines in toxicology, human and veterinary medicine, biology, chemistry, and physics forms the basis for comprehensive contract research work and services, including preclinical and clinical testing, drug research, consumer and environmental protection. Drug research with scope of application by inhalation is an important part of our activities. Product Categories: Clinical Toxicology/Testing, CRO—Contract Research Organization, In Vitro Research/Testing, Inhalation Research/Testing, Risk Assessment

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Gene Tools LLC 2028 1001 Summerton Way Philomath, OR 97370 United States Tel: 541.929.7840 Fax: 541.929.7841 Email: [email protected] Website: www.gene-tools.com Gene Tools manufactures Morpholino oligos for blocking translation, modifying splicing or inhibiting miRNA activity. Morpholinos EXHIBITOR DESCRIPTIONS EXHIBITOR are used in cell cultures, embryos or, as Vivo-Morpholinos, in adult animals. Morpholinos are effective, specific, stable and non-toxic. Backed by Ph.D.-level customer support, Gene Tools designs and synthesizes Morpholinos and offers cytosolic delivery options. Product Categories: Biochemistry, Biotechnology Products, Gene Expression, In Vivo Research/Testing, Molecular Biology/ Products/Synthesis Genentech 1032

1 DNA Way ★ 2015 Gold Level Supporter South San Francisco, CA 94080-4990 ▲ SOT Affiliate United States Tel: 650.225.2580 Fax: 650.225.6000 Website: www.gene.com We’re passionate and rigorous about our science. For over 30 years, Genentech has been at the forefront of the biotechnology industry, using human genetic information to develop novel medicines for serious or life-threatening diseases. Our Safety Assessment Department delivers expertise in veterinary pathology, toxicology and investigative toxicology. We design, implement, interpret and communicate results of preclinical studies that enable informed decisions with comprehensive risk assessments. Product Categories: Biotechnology Research/Testing, Developmental Toxicology, Pathology, Pharmaceutical Product Safety/ Toxicology, Safety Assessment Genox Corporation 1210 1414 Key Highway, Suite 300 Baltimore, MD 21230 United States Tel: 410.347.7616 Toll Free: 800.810.5450 Fax: 410.347.7617 Email: [email protected] Website: www.genox.com Genox Corporation offers products and in-house analytical testing services to measure the oxidative damage biomarkers. Products include ELISA kits and monoclonal antibodies to measure the DNA damage, protein damage, and lipid oxidation biomarkers. Analytical services are provided to test for antioxidative activity and oxidative damage biomarkers. Product Categories: Antibody Products, Biomarkers, Clinical Chemistry/Laboratory Analysis, Immunohistochemistry Research/ Supplies, In Vitro Research/Testing

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Gentronix, Limited 1130 Biohub at Alderley Park Alderley Edge, Cheshire SK10 4TG United Kingdom Tel: +44 7792 215 300 Fax: +44 1625 238 701 Email: [email protected] Website: www.gentronix.co.uk Gentronix provides services and solutions to help chemistry driven organisations develop safer products more quickly at lower cost. We invented GreenScreen HC and BlueScreen HC available worldwide as reagent kits and as a service. We are GLP compliant providing Ames (OECD 471), MNT (OECD 487) as well as Ames screening, Flow MNT, in vivo MNT analysis, comet, apoptosis and cytotoxicity . Come and visit us at Booth 1130 during ToxExpo 2015, and visit our website www.gentronix.co.uk. Product Categories: CRO—Contract Research Organization, Genotoxicity Products/Services, GLP—Good Laboratory Practice Services, Preclinical Research/Testing, Regulatory Services/Toxicology Gyros 1044 30 Technology Drive Suite 1F Warren, NJ 07059 United States Tel: 908.755.0011 Email: [email protected] Website: www.gyros.com Gyros manufactures innovative laboratory platforms and kits that maximize productivity by miniaturizing and automating immunoassays at nanoliter-scale. Gyrolab open platforms accelerate assay development and bioanalysis for time critical workflows in R&D and preclinical tox. Its' affinity flow-through format, eliminates incubations with shorter run times. Gyros’ technology ensures high reproducibility and productivity with Gyrolab platforms that process up to 112 data points per CD in an hour. Product Categories: Analytical Instruments, Biomarkers, Ophthalmic Research/Testing, Pharmacokinetics, Toxicokinetics H&T Corporation 2019 2-20-4 Morikawachi-Nishi, Higashi-Osaka Osaka, 577-0061 Japan Tel: +81 6 6785-3322 Fax: +81 6 6785-3435 Email: [email protected] Website: www.ht21.co.jp H&T Corporation has been proudly dedicated to develop a preclinical testing support system TOX-LAUNCHER for more than a decade. Since pathologists’ ideas are fully reflected on the system, data management and report creations are flexible enough to operate varieties of studies along with FDA 21 CFR Part11 and other regulations. The user-friendly system can suit both GLP and non-GLP laboratories. Please visit booth 2019 and check TOX-LAUNCHER and other product lines. Product Categories: Data Management, Data Reporting Systems, Software

Products and Services 365 days of the year—Visit ToxExpo.com 66 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo EXHIBITOR DESCRIPTIONS

Hamilton Thorne 1232 100 Cummings Center, Suite 465 E Beverly, MA 01915 United States Tel: 978.921.2050 Toll Free: 800.323.0503 Fax: 978.921.0250 Email: [email protected] Website: www.hamiltonthorne.com EXHIBITOR DESCRIPTIONS EXHIBITOR Hamilton Thorne presents the TOX IVOS sperm analyzer for reproductive toxicology studies of rat sperm and sperm of other laboratory animals. Also available on the TOX IVOS is our VIADENT option for determining viability on the same live sample used for motility analysis. For those studying fish sperm, the CEROS analyzer with cooling stage maintains the sample at optimum temperature during analysis. Both systems are 21 CFR Part 11 compliant. Product Categories: Aquatic Sciences/Testing, Clinical Toxicology/Testing, Fish Toxicology, Medical Devices/Testing HemoGenix Inc. 1109 1485 Garden of the Gods Road, Suite 152 Colorado Springs, CO 80907 United States Tel: 719.264.6250 Fax: 719.264.6253 Email: [email protected] Website: www.hemogenix.com HemoGenix is a contract research testing and development company that specializes in in vitro assay toxicity testing on primary stem and progenitor cells from a variety of organs and tissues and from multiple species. HemoGenix is the "gold standard" in hemotoxicity testing. Other high-throughput assays are available for, but not limited to, immuno-, MSC, neuro- and hepatotoxicity. We work with other CROs to perform in vitro tox studies on ex vivo primitive cells from preclinical animal studies. Product Categories: Biotechnology Research/Testing, Hematology, High-Throughput Test Systems, In Vitro Research/Testing, Nonclinical Research Hepregen Corporation 629 200 Boston Avenue, Suite 1500 Medford, MA 02155 United States Tel: 781.391.0205 Fax: 781.391.0315 Email: [email protected] Website: www.hepregen.com Hepregen is the exclusive provider of in vitro ADME/Tox products and services using HepatoPac, a novel and highly predictive microliver culture platform that remains functional for several weeks. HepatoPac is an ideal platform for many investigative and mechanistic drug safety applications such as chronic, metabolism-mediated, and inflammation-mediated toxicities. HepatoPac has been developed for human and other preclinical species models and is in use at many global pharmaceutical companies. Product Categories: In Vitro Metabolism, In Vitro Research/Testing, Metabolism Studies, Pharmaceutical Product Safety/ Toxicology

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Histo-Scientific Research Laboratories (HSRL) 1103 5930 Main Street Mt. Jackson, VA 22842 United States Tel: 540.477.4440 Fax: 540.477.4448 Email: [email protected] Website: www.hsrl.org HSRL's necropsy, histology, pathology, and archiving services are known for expertise, quality, and efficiency. We support GLP studies in a responsive and cost-effective manner. Necropsy services are provided at your facility. The quality of our slides is exceptional. Our board-certified pathologists have extensive experience, specializing in various fields of expertise. HSRL Archives offers ambient, refrigerated, and frozen storage along with worldwide shipping logistics. Product Categories: Archiving/GLP Compliant Archiving, GLP—Good Laboratory Practice Services, Histopathology, Pathology HistoTox Labs, Inc. 1716 2108 55th Street, Suite 110 Boulder, CO 80301 United States Tel: 303.633.5401 Fax: 303.565.3764 Email: [email protected] Website: www.histotoxlabs.com HistoTox Labs is a GLP-compliant contract laboratory performing histology, immunohistochemistry and pathology services for preclinical toxicity, arthritis, cancer, and inflammation-related studies. Our commitment to outstanding customer service, high-quality sections, competitive pricing and quick turnaround times, have made HistoTox Labs the ideal source for reliable histopathology services for over 10 years. Product Categories: CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, Histopathology, Immunohistochemistry Research/Supplies, Pathology HTG Molecular Diagnostics 1208 3430 E Global Loop Tucson, AZ 85706 United States Tel: 520.901.2135 Email: [email protected] Website: www.htgmolecular.com HTG Molecular provides a novel, automated technology platform that quickly and simultaneously profiles thousands of clinically relevant molecular targets from samples a fraction of the size required by other technologies. The HTG Edge system was developed to facilitate routine use of complex molecular profiling for research or clinical labs. Product Categories: Biomarkers, Gene Expression, Instruments, Microarrays, Preclinical Research/Testing

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Huntingdon Life Sciences/Harlan Laboratories 1515

PO Box 2360, Mettlers Road ▲ SOT Affiliate East Millstone, NJ 08875-2360 25 years or more ToxExpo Exhibitor United States Tel: 732.873.2550 Fax: 732.873.8899 Email: [email protected] Website: www.harlan.com Huntingdon Life Sciences/Harlan is an international contract research organization offering a comprehensive range of non-clinical EXHIBITOR DESCRIPTIONS EXHIBITOR development services to pharmaceutical, biopharmaceutical, crop protection, and chemical companies. Our mission is to help our customers develop safe and effective new compounds that make a real difference to people’s lives. Our Research Models and Services operating group provides high-quality research models and lab animal diets with support services worldwide. Product Categories: Agrochemical Product Safety/Toxicology, Animal Models, Chemical Product Safety/Toxicology, Inhalation Research/Testing, Preclinical Research/Testing Hµrel Corporation 2116 675 US Highway 1 North Brunswick, NJ 08902 United States Tel: 919.265.8210 Email: [email protected] Website: www.hurelcorp.com HµREL® Corporation develops advanced liver tissue constructs and microfluidic cell-based assay platforms for preclinical predictive toxicology, drug metabolism and pharmacokinetics. HµREL®’s stable, high-functioning metabolic competency and long endurance, enable novel in vitro experiments including long-term multiple dosing toxicity, metabolic clearance, long-term CYP inhibition or metabolite generation studies. HµRELflow recirculating microfluidics allow for multi-tissue interactions. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Cells/Tissue, CRO- Contract Research Organization, In Vitro Research/Testing, Microfluidics Hurley Consulting Associates, Ltd. 2328 25 DeForest Avenue Summit, NJ 07901 Tel: 908.273.8490 Fax: 908-273-2670 Email: [email protected] Website: www.hurleyconsulting.com For over 25 years, Hurley Consulting Associates has specialized in Finding Solutions for its clients' regulatory and commercial development needs. With unique expertise to prepare global regulatory submission documents, we integrate nonclinical, clinical and CMC evaluations; perform data analyses and develop regulatory strategies. We can serve as your US agent for regulated products for the entire IND through NDA process. Stop by our booth for more information. Product Categories: Consulting Services, CRO—Contract Research Organization, Pharmacology, Regulatory Services/Toxicology, Statistical Analysis Services

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ICDD-sas 731 800 avenue du Chateau de Jouques Gemenos, 13420 France Tel: +33 484 830 020 Email: [email protected] Website: www.icdd-sas.com ICDD-sas is a science-based company, established as a contract research provider in predictive toxicology. ICDD-sas uses its proprietary platforms centered on the mitochondrion, to select the safest drugs from the most active lead molecules developed and provided by our clients. ICDD also partners with drug developers for the discovery and development of companion diagnsotic identifying tolerance and efficacy of drugs in clinical responders. Talk to our representative for more info. Product Categories: Biomarkers, Neurobiology/Neurotoxicology, Preclinical Research/Testing, Risk Assessment, Safety Assessment ICF International 2128 9300 Lee Highway Fairfax, VA 22031 United States Tel: 703.934.3000 Fax: 703.934.3740 Email: [email protected] Website: www.icfi.com ICF International delivers technical consulting services to public and private sector clients in areas ranging from environmental exposure and human health risk sciences to IT services and public health data surveys. Our scientists, managers, and programmers collaborate with clients to implement robust analyses and creative solutions for emerging needs such as transparent systematic data review. ICF is distinguished by our innovation and commitment to exceeding client expectations. Product Categories: Chemical Product Safety/Toxicology, Data Management, Environmental Health, Modeling Products/Services, Risk Assessment IDEXX Laboratories, Inc. 1112

One IDEXX Drive ★ 2015 Contributor Level Supporter Westbrook, ME 04092 United States Tel: 760.518.9198 Email: [email protected] Website: www.idexxbioresearch.com IDEXX BioResearch provides analytical and diagnostic testing services and instrumentation specifically designed for mice, rats, nonhuman primates and other common research species. Our comprehensive menu of analytical services, including health monitoring, preclinical testing services, veterinary clinical trial support and cell-line quality assurance deliver accurate, reliable data and simplify your ability to conduct quality research. Product Categories: Clinical Chemistry/Laboratory Analysis, Hematology, Histopathology, Preclinical Research/Testing, Veterinary Contract Laboratories

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IIT Research Institute (IITRI) 1719 10 W 35th Street 25 years or more ToxExpo Exhibitor Chicago, IL 60616 United States Tel: 312.567.4924 Fax: 312.567.4106 Email: [email protected] Website: www.iitri.org IIT Research Institute (IITRI) is a preclinical CRO delivering comprehensive and high-quality drug discovery and GLP safety testing EXHIBITOR DESCRIPTIONS EXHIBITOR services. We provide our sponsors with a highly experienced and collaborative scientific team for seamless study execution. Areas of specialty include complete GLP safety testing to support IND and NDA submissions, bioanalytical services through Phase II clinical trials, inhalation toxicology, cancer drug development, and extensive infectious disease capabilities. Product Categories: CRO—Contract Research Organization, In Vivo Research/Testing, Pharmaceutical Product Safety/Toxicology, Preclinical Research/Testing, Respiratory Toxicology ImQuest BioSciences 612 7340 Executive Way Suite R Frederick, MD 21704 United States Tel: 301.696.0274 Email: [email protected] Website: www.imquestbio.com ImQuest BioSciences is a preclinical contract research and development company that evaluates the potential of new and novel pharmaceutical products. We provide expert laboratory research services to define the efficacy and toxicity of pharmaceutical products and specialize in the development of drugs, vaccines and biologic products for the treatment and prevention of infectious disease, cancer and inflammatory disease. Product Categories: CRO—Contract Research Organization, In Vitro Research/Testing, Mechanistic Research/Testing, Microbiological Research/Testing, Pharmaceutical Formulations, Preclinical Research/Testing, Virology Research/Testing In Vitro ADMET Laboratories (IVAL) 1420

9221 Rumsey Road, Suite 8 25 years or more ToxExpo Exhibitor Columbia, MD 21045 United States Tel: 410.869.9037 Toll Free: 866.458.1094 Fax: 410.869.9034 Email: [email protected] Website: www.invitroadmet.com Complete Hepatocyte Solutions for in vitro drug development: Premier provider of pooled cryopreserved hepatocytes from human and animal species for use in drug development research. Expertise in evaluating drug efficacy and adverse effects using primary animal and human hepatocytes with cell and molecular endpoints (gene expression), robot-assisted high-throughput evaluation of P450 inhibition, P450 induction, organ-specific toxicity, and IdMOC platform for multiple organ toxicity. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), CRO—Contract Research Organization, Gene Expression, In Vitro Metabolism, Preclinical Research/Testing

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INDIGO Biosciences, Inc. 1006 1981 Pine Hall Road State College, PA 16801 United States Tel: 814.234.1919 Fax: 814.272.0152 Email: [email protected] Website: www.INDIGObiosciences.com With INDIGO’s nuclear receptor experts at your service, you get results you can be confident in, every time. With our convenient lab- in-a-box assay kits, you can bring the power of INDIGO into your lab to perform quick, simple, and reliable in-house discovery and toxicology screening. If you’d rather put our experts to the test, send us your compounds and we’ll screen them in our lab. Either way, when you need fast, accurate results, trust the Nuclear Receptor Experts. KNOW INDIGO Product Categories: Acute Toxicology Services/Testing, CRO—Contract Research Organization, Gene Expression, Microarrays Infinite Trading Inc 936 3651 Lindell Road, Suite D120 Las Vegas, NV 89103 United States Tel: 888.415.9964 Email: [email protected] Website: www.hidow.com/ Hi-Dow's mission is to provide pain relief to consumers who suffer with chronic and acute body aches and stiffness with the use of federally tested and approved electrophysiology therapy massagers. We also combine aggressive strategic marketing, quality products and services at an affordable price for the best in pain relief to our customers. Product Categories: Electronics InSphero Inc. 2318 CTI Desk/Swissnex, 420 Broadway Cambridge, MA 02138 United States Tel: 800.779.7558 Email: [email protected] Website: www.insphero.com InSphero is the leading provider of 3D InSight™ Microtissues and screening services to the pharmaceutical, cosmetics and chemical industry. Our assay-ready 3D InSight™ Liver Microtissues (human, rat, HepG2, dog, minipig) enable more biologically relevant and predictive in vitro compound assessment, including long-term and idiosyncratic toxicity. Produced to ISO standards using GravityPLUS™ hanging drop technology, our growing microtissue pipeline includes cardiac, pancreatic, and neural models. Product Categories: Cancer Biology/Carcinogenicity, Cosmetic Product Safety/Toxicology, In Vitro Research/Testing, Pharmaceutical Product Safety/Toxicology, Reproductive Toxicology Instech Laboratories 1535 5209 Militia Hill Road 25 years or more ToxExpo Exhibitor Plymouth Meeting, PA 19462 United States Tel: 800.443.4227 Fax: 610.941.0134 Email: [email protected] Website: www.instechlabs.com Instech Laboratories is a leader in laboratory animal infusion and sampling with a focus on improving efficiency and adherence to the 3Rs. *PinPort™ streamlines access to externalized catheters *Plastic feeding tubes minimize trauma during oral gavage *Vascular Access Harnesses™ simplify connection of tethered mice and rats *ABS2™ automates the collection of blood samples from mice, rats and large animals *OrchesTA™software and infusion pumps automate rodent and large-animal GLP infusion studies. Product Categories: Animal Equipment, Infusion Equipment, Pumps, Surgical Instruments

Products and Services 365 days of the year—Visit ToxExpo.com 72 Follow us on Twitter at @SOToxicology and @ToxExpo Tweet using #2015SOT and #toxexpo Global Gallery of Toxicology A Worldwide Vision for Toxicology

Toxicology-related scientific societies from around the world are invited to display a poster showcasing their key information, accomplishments, strategic initiatives, and activities. Attendees interested in collaboration and discussion are invited to the Global Gallery Monday, March 23, 11:45 am–12:15 pm, for a representative-attended poster session with all Global Gallery participants. In addition to the 30 2014 Global Gallery participating societies, new participants for the 2015 Annual Meeting include: • Bulgarian Society of Toxicology • Chinese Society of Toxicology • Estonian Society of Toxicology • French Society of Toxicology • • International Society for the Study of Xenobiotics • International Society of Exposure Science • • Israeli Society of Toxicology • Japanese Society of Immunotoxicology • Korean Society of Toxicology • • Scientific Liaison Coalition • Society for Risk Analysis • Swedish Society of Toxicology •

Poster sare displayed prominently in the ToxExpo Exhibit Hall.

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Instem 1127 161 Washington Street, Suite 1550 25 years or more ToxExpo Exhibitor Conshohocken, PA 19428 United States Tel: 610.941.0990 Fax: 610.941.0992 Email: [email protected] Website: www.instem.com Come see Provantis®, the premier preclinical software solution for data collection and management that streamlines processes for single users to multi-site global organizations. Now that FDA Final Guidance has been posted, be sure to ask us about SEND and the market-leading submit™ solution and services that more than 30 CRO and Sponsor sites in 11 countries have licensed and utilized. Stop by and see why over 400 clients have chosen an Instem technology to help enhance and improve their research. Product Categories: Computing Systems, Data Management, Data Reporting Systems, Software Institute for In Vitro Sciences, Inc. 1026 30 W. Watkins Mill Road, Suite 100 Gaithersburg, MD 20878 United States Tel: 301.963.4945 Fax: 301.947.6538 Email: [email protected] Website: www.iivs.org The Institute for In Vitro Sciences, Inc. is a nonprofit research and testing laboratory dedicated to the advancement of in vitro methods worldwide. Our familiarity with an array of different in vitro test systems enables us to provide contract testing services using the optimum assays to answer specific product safety and efficacy questions. Our laboratory team has experience in conducting in vitro assay validation studies, and providing hands-on training to an international audience. Product Categories: Chemical Product Safety/Toxicology, Consumer Product Safety/Toxicology, Cosmetic Product Safety/ Toxicology, Efficacy Testing, In Vitro Research/Testing Integrated Analytical Solutions, Inc. 733 1456 Fourth Street, Unit C Berkeley, CA 94710 United States Tel: 510.649.9016 Fax: 510.649.9017 Email: [email protected] Website: www.ianalytical.net Integrated Analytical Solutions, Inc. (IAS) is a contract DMPK company focused on delivering rapid data turn-around in the areas of LC-MS/MS bioanalysis, drug metabolism, and general analytical services. We provide expert bioanalytical services to support both GLP and non-GLP pharmacokinetic and toxicokinetic evaluation of research compounds. Our capabilities in the area of drug metabolism range from standard in vitro stability screens to advanced guidance for metabolite identification. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Bioanalytical Services, In Vitro Metabolism, LC/ MS-Liquid Chromatography/Mass Spectroscopy, Metabolism Studies

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Integrated Laboratory Systems, Inc. (ILS) 708 P O Box 13501 Research Triangle Park, NC 27709 United States Tel: 919.281.1110 Fax: 919.281.1118 Email: [email protected] Website: www.ils-inc.com ILS provides customized solutions for customers in both commercial and government segments. We are a leading company with EXHIBITOR DESCRIPTIONS EXHIBITOR world-class scientists in toxicology, pathology, histology, and the environmental and information science fields. ILS has a flexible and comprehensive service model. We provide an entire suite of scientific services consisting of study design, execution, sample analysis and scientific interpretation/dissemination, or we can provide individual components that meet your needs. Product Categories: Acute Toxicology Services/Testing, Agrochemical Product, Safety/Toxicology, Animal Models, Consulting Services, Endocrinology Research/Testing, Histopathology, Risk Assessment, Immunohistochemistry Research/Supplies, In Vitro Research/Testing, In Vivo Research/Testing, Literature Searches, Pathology, Preclinical Research/Testing Integrated Nonclinical Development Solutions, Inc 1343 6111 Jackson Road, Suite 100 Ann Arbor, MI 48103 United States Tel: 734.929.5392 Fax: 734.929.5303 Email: [email protected] Webstie: www. inds-inc.com Integrated Nonclinical Development Solutions (INDS) provides creative and effective strategic/tactical nonclinical drug development consulting and IT services for pharma and biotechs. We support development from FIH to registration and provide custom application development, data warehousing, system integration, and SEND implementation services. Our new SEND Explorer product line enables review, search, visualization, and warehousing of SEND data. For more info, visit our booth or inds-inc.com. Product Categories: Consulting Services, Nonclinical Research, Pharmaceutical Product Safety/Toxicology, Safety Assessment, Software IntelliCyt Corporation 807 9620 San Mateo Boulevard NE Albuquerque, NM 87113 United States Tel: 505.345.9075 Fax: 866.782.3140 Email: [email protected] Website: www.intellicyt.com IntelliCyt’s screening systems and application-specific kits are optimized and validated to identify and characterize cytotoxicity. Analyze the health of thousands of cells per second with 96-well run times of 3 to 5 minutes. Learn about our micronucleus application that enables the fastest available genotoxicity screening method for the detection of micronuclei (claustogen-induced) and hypodiploid nuclei (aneugen-induced). Product Categories: Antibody Products, Cytology/Cytometry Services/Supplies, High-Throughput Test Systems, In Vitro Research/ Testing

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International Institute for the Advancement of Medicine 1820 125 May Street Edison, NJ 08837 United States Tel: 845.694.8440 Toll Free: 800.486.4426 Fax: 732.661.2527 Email: [email protected] Website: www.iiam.org IIAM is the world-leading provider of healthy and diseased, fresh, human organs for medical research, education and development. These biomaterials are recovered with minimal ischemia from organ transplant donors who have authorized use of the non- transplantable organs for research. IIAM has been providing these biomaterials to qualified researchers, scientists, biotech and healthcare professionals for almost 30 years. Let us serve your research needs. Please contact [email protected]. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Biomedical Research Products, Cells/Tissue, In Vitro Research/Testing, Preclinical Research/Testing Intertek 2115 10420 Wateridge Circle San Diego, CA 92121 United States Tel: 858.558.2599 Email: [email protected] Website: www.intertek-pharma.com Intertek offers 20+ years in bioanalysis and regulatory consulting experience for preclinical and clinical projects. Expert support for both small molecule LC-MS and biologics immunochemistry at our GLP laboratories in CA and Europe provided on method development, validation, and High-Throughput analysis from TK, PK, immunogenicity, to Cell-based services. Also scientific and regulatory consultancy address challenges of product development, regulatory approval and [email protected]. Product Categories: Bioanalytical Services, CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, LC/MS-Liquid Chromatography/Mass Spectroscopy, Toxicokinetics InvitroCue 2210

81 Science Park Drive, #02-03 The Chadwick Please see our ad on page 73. Singapore, 118257 Singapore Tel: +65 8268 1220 Email: [email protected] Website: www.invitrocue.com InvitroCue offers products and services for in vitro DMPK and in vitro toxicology testing, the modeling of infectious diseases, as well as toxicologic and digital pathology. The company utilizes innovative 3D cell culture models, cell lines and image analytics to support better decision making in preclinical studies, clinical trials and diagnostics. Headquartered in Singapore, the company serves research institutes, pharmaceutical companies and CROs across Southeast Asia and China. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Cells/Tissue, CRO—Contract Research Organization, Pathology, Pharmaceutical Product Safety/Toxicology

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Ionic Transport Assays, Inc 909 1100 Corporate Square Drive St. Louis, MO 63132 United States Tel: 314.743.7922 Email: [email protected] Website: www.ionictransport.com Ionic Transport Assays is a contract research organization (CRO) dedicated to establishing and performing manual cellular pharmacology assays on adult human induced pluripotent stem cell-derived (iPSC) cardiomyocytes to evaluate the effects of new EXHIBITOR DESCRIPTIONS EXHIBITOR drugs before they reach clinical trials. Ionic Transport Assays uses physiologically relevant cells that replicate the behavior of a native cardiac cell. We assess drug safety with these cells and save our clients’ time and money to make safer drugs. Product Categories: CRO—Contract Research Organization, Pharmaceutical Product Safety/Toxicology, Preclinical Research/ Testing, Safety Assessment IPS Therapeutique 1134 975 Leon-Trepanier Sherbrooke, QC J1G 5J6 Canada Tel: +819.820.1515 Fax: +819.820.1516 Email: [email protected] Website: www.ipstherapeutique.com IPST started its contract research activities in 1999 by conducting hERG inhibition patch-clamp assays on transfected cell lines and freshly dispersed myocytes. IPST’s services expanded to efficacy and cardiac safety studies, with vascular and cardiac muscle tension measurements and isolated organ models. Our in vitro and ex-vivo assays are fully GLP-compliant. A new line of in vivo pathology models was validated in 2010 to enhance IPST’s extensive range of efficacy services. Product Categories: CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, In Vitro Research/Testing, In Vivo Research/Testing, Safety Assessment ITR Canada (Bozo & ITR Group) 1827 19601 Clark Graham Boulevard 25 years or more ToxExpo Exhibitor Baie D Urfe (Montreal), QC H9X 3T1 Canada Tel: +514.457.8527 Email: [email protected] Website: www.itrlab.com Located in Canada and Japan, ITR Group’s GLP-compliant safety testing services can support your next product registration effort in any global market. We perform studies in general toxicology, infusion, inhalation, safety pharmacology, immunology, DART, genetic toxicology lab support services include analytical, bioanalytical, ligand binding (PK, PD and biomarkers) assays, and flow cytometry. Work with us and discover how pleasant and productive a customer centric philosophy can be. Product Categories: Biotechnology Research/Testing, CRO—Contract Research Organization, Immunology Research/Testing, Inhalation Research/Testing, Pharmaceutical Product Safety/Toxicology

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IUTOX 537 1821 Michael Faraday Drive, Suite 300 Reston, VA 20190 United States Tel: 703.438.3103 Fax: 703.438.3113 Email: [email protected] Website: www.iutox.org Founded in 1980, IUTOX has 63 member societies representing countries in six continents comprised of nearly 25,000 toxicologists from industry, academia and government. As a WHO NGO, IUTOX provides risk assessment, education, and training and other capacity building activities to scientists in developing and least developed countries. Visit us at www.iutox.org to learn more about our 9th Congress of Toxicology in Developing Countries being held in Natal, Brazil November 7–10, 2015, and our International Congress of Toxicology scheduled for October 2–6, 2016, in Merida, Mexico. Product Categories: International Organizations, Risk Assessment Jackson Laboratory, The 1107 600 Main Street Bar Harbor, ME 04609 United States Tel: 207.288.6000 Email: [email protected] Website: www.jax.org The Jackson Laboratory is an independent, nonprofit biomedical research institution based in Bar Harbor, ME, with facilities in California and Connecticut. Our mission is to discover precise genomic solutions for disease and empower the global biomedical community in our shared quest to improve human health. We distribute more than 6,000 mouse strains, provide enabling tools, curate critical data and deliver services that help to realize the goals of research and clinical communities worldwide. Product Categories: Animal Models, Efficacy Testing, In Vivo Research/Testing, Preclinical Research/Testing Jai Research Foundation (JRF - America) 919 N.H. 8, Near Daman Ganga Bridge Valvada, Vapi, Gujarat 396105 India Tel: +91-990-990-0905 Email: [email protected] Website: www.jrfglobal.com JRF is a GLP and an AAALAC-accredited global preclinical CRO with labs in the US, Japan, India, and the UK. Over 20,000 of our GLP reports have been well received by global regulators like FDA, EMA, etc. Our IND enabling safety assessments include mammalian, inhalation, developmental, and reproductive toxicology; geno, immuno and neurotoxicity, carcinogenicity, EDSP, DMPK, in vitro toxicology and Zebra fish discovery research. Please visit our booth to enjoy Indian Masala Tea with our Toxicologists! Product Categories: Acute Toxicology Services/Testing, ADME (Absorption/Distribution/Metabolism/Excretion), Cancer Biology/ Carcinogenicity, Chronic Toxicology, CRO—Contract Research Organization, Dermal Research/Testing, Pharmaceutical Product Safety/Toxicology, Preclinical Research/Testing, Reproductive Toxicology, Developmental Toxicology, Ecology/Ecotoxicology Services, Endocrinology Research/Testing, Genotoxicity Products/Services, In Vitro Research/Testing, Inhalation Research/Testing

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Japanese Society of Toxicology 539 Medical Tribune, Inc., Italian Cultural Institute Bldg. 8F, 2-1-30 Kudan Minami, Chiyoda-ku Tokyo, 102-0074 Japan Tel: +81-3-3239-7264 Fax: +81-3-3239-7225 Email: [email protected] Website: www.jsot.jp/english In 1975 and 1976, The Toxicology Research Group and the Toxic Action Research Group were formed, respectively, and in 1981, EXHIBITOR DESCRIPTIONS EXHIBITOR these two merged to JSOT, which now has over 2,600 members, second largest among IUTOX members. Our mission is to advance health through understanding of toxicology, and to stimulate research in toxicology by 1) Annual meeting, 2) Publishing The Journal of Toxicological Sciences, 3) Education and certification of toxicologists (DJSOT), and other scientific/publicity activities. Product Categories: Organizations KAER Biotherapeutics 1841 926 S. Andreasen Drive, Suite 105 Escondido, CA 92029-1939 United States Tel: 760.744.0075 Fax: 760.480.9401 Email: [email protected] Website: www.kaerbio.com KAERTM specializes in high-dose rate generation and delivery of aerosols, especially biologics (6g/m3, protein). SUPRAER generates a large liquid aerosol of the active agent that is rapidly dried, concentrated and delivered as a solid phase aerosol of pure agent. SARES, small animal respiratory aerosol exposure system facilitates the delivery of these aerosols to 12 rats or guinea pigs. Applications include, safety pharmacology, toxicology, drug discovery, vapor generation and spray drying. Product Categories: Acute Toxicology Services/Testing, Environmental Research/Services/Testing, Inhalation Research/Testing, Pulmonary Equipment/Research, Respiratory Toxicology Kallistem 2332 ENS Lyon 46 allée d’Italie Lyon, 69364 cedex 07 France Tel: +336-801-75812 Email: [email protected] Website: www.kallistem.com/en Kallistem is a biotech company specialized in male fertility and spermatogenesis in vitro. We propose services on predictive testicular toxicology based on a 3D Testicular Cell Culture model: Bio-AlteR®. This system achieves all the key steps of spermatogenesis. It is used as a robust and reliable tool for the evaluation of the toxic effect of substances on male fertility. Our commitment is to support our customers in testicular toxicity issues by offering in vitro tests the most relevant. Product Categories: Biotechnology Research/Testing, Chemical Product Safety/Toxicology, CRO—Contract Research Organization, Pharmaceutical Product Safety/Toxicology, Reproductive Toxicology

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KCAS Bioanalytical Services 727 12400 Shawnee Mission Parkway Shawnee, KS 66216 United States Tel: 913.248.3000 Fax: 913.248.3106 Email: [email protected] Website: www.kcasbio.com KCAS Bioanalytical Services is a contract research organization (CRO) with 35+ years of bioanalytical and immunoanalytical expertise. Our experienced scientific team specializes in the development and validation of robust small molecule, large molecule and biomarker methods for preclinical and clinical studies. Learn more at www.kcasbio.com. Product Services: Bioanalytical Services, Biomarkers, CRO—Contract Research Organization, Preclinical Research/Testing, Toxicokinetics Kingfisher Biotech 930 1000 Westgate Drive Suite 123 St. Paul, MN 55114 United States Tel: 651.646.0089 Fax: 651.646.0095 Email: [email protected] Website: www.kingfisherbiotech.com Kingfisher Biotech, Inc. is committed to accelerating basic veterinary research and human disease research done in animal models by developing and commercializing research reagents specific for a variety of species, including bovine, canine, chicken, equine, feline, guinea pig, hamster, human, mouse, ovine, rabbit, rat, swine, and turkey. Currently, we offer over 1200 recombinant proteins, polyclonal antibodies, monoclonal antibodies, and ELISA kits for animal health and animal model research. Product Categories: Antibody Products, Biomarkers, Biotechnology Products, Veterinary Product Development Korea Institute of Toxicology (KIT) 1117 141 Gajeong-ro, Yuseong-gu, PO Box 123 Daejeon, 305-600 Korea (South) Tel: +82-42-610-8204 Fax:+82-42-610-8085 Email: [email protected] Website: www.kitox.re.kr/eng Korea Institute of Toxicology (KIT) is a world-class prestigious nonclinical contract research organization located in South Korea. KIT’s GLP system has been certified by Korean and international regulatory authorities based on OECD and US.FDA GLP criteria. Also, KIT is the first organization in Asia accredited by AAALAC International for humane laboratory animal treatment. KIT offers a full range of nonclinical research with high scientific standards and competitive prices. Product Categories: CRO—Contract Research Organization, Inhalation Research/Testing, Preclinical Research/Testing, Risk Assessment, Safety Assessment

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Kunming Biomed International (KBI) 1644 No. 1 Boda Rd, Yuhua Area, Cheng-Gong New Town Kunming, 650500 China Tel: +1 650 283 6724 Fax: +868 716 5952827 Email: [email protected] Website: www.kbimed.com Kunming Biomed International (KBI), located in southwest China, is a CRO providing preclinical research services specialized EXHIBITOR DESCRIPTIONS EXHIBITOR in non-human primates. The core competency of KBI is to provide non-human primate disease models to test drug candidates and medical devices for their pharmacological effects and biocompatible repairs. We also conduct adjacency studies in PK/PD, in vivo pharmacology, histology/pathology, and preliminary non-GLP toxicology. KBI has already achieved AAALAC accreditation. Product Categories: Animal Models, CRO—Contract Research Organization, Nonclinical Research, Primate Supplies/Testing Lab Products, Inc. 1400 742 Sussex Avenue 25 years or more ToxExpo Exhibitor Seaford, DE 20852 United States Tel: 800.526.0469 Fax: 302.628.4309 Email: [email protected] Website: www.labproductsinc.com Lab Products remains the world’s leading innovator of laboratory animal housing and care equipment. We provide cost-effective solutions for housing animals ranging from mice to non-human primates. Each system is designed to help ensure the well-being of animals and personnel, meet your research requirements and minimize experimental variables. Product Categories: Animal Equipment, Animal Husbandry, Caging, Inhalation Equipment, Manufacturing-Custom LabLogic Systems, Ltd. 1212 Paradigm House, 3 Melbourne Avenue Broomhill, Sheffield United Kingdom Tel: +44 114.266.7267 Fax: +44 114 266 39 44 Email: [email protected] Website: www.lablogic.com LabLogic Systems is the leading provider of LIMS and radiochromatography instrumentation and software for drug metabolism. Our products include: Debra LIMS for ADME studies, Laura radiochromatography software, B-RAM Model 5 rHPLC detector, Seescan for quantitative whole body autoradiography, Stacy sample tracking, and radioisotope inventory. Product Categories: Chromatography Products, Data Acquisition, Data Management, Instruments, Software Lampire Biological Laboratories, Inc. 1002 PO Box 270 Pipersville, PA 18947 United States Tel: 267.772.7013 Fax: 215.795.0237 Email: [email protected] Website: www.lampire.com Lampire provides zebrafish and rat embryo teratogenicity studies, in vitro ADME services, custom polyclonal and monoclonal antibody services, peptide synthesis, antibody purification and conjugation, cell culture services, and immunoassay development. Products include the LAMPIRE OMNI, Cell Culture Bag, IgGs, secondary antibodies, plus a wide variety of blood products and tissues. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Antibody Products, CRO—Contract Research Organization, Developmental Toxicology, Pharmaceutical Product Safety/Toxicology

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Leadscope, Inc. 716 1393 Dublin Road Columbus, OH 43215 United States Tel: 614.675.3730 Toll Free: 888.785.6483 Fax: 614.675.3732 Email: [email protected] Website: www.leadscope.com Leadscope produces high-quality QSAR models and databases. Our Model Applier meets all the requirements of ICH M7 Guidance on testing for impurities. Our Model Applier produces an ICH M7 consensus prediction as used by the US FDA. Our consensus prediction incorporates the statistical QSAR models; expert alerts results and experimental data. We will also be demonstrating our new “Regulatory Submission Tool”, which is a wizard-based tool to assist in preparing a submission for ICH M7. Product Categories: Modeling Products/Services, QSAR (Quantitative Structure Activity Relationship) Modeling/Analysis, Safety Assessment, Software Leyden Group 1814 640 Plaza Drive, Suite 330 Highlands Ranch, CO 80129 United States Tel: 303.865.2897 Email: [email protected] Website: www.leydengroup.com The Leyden Group is a Colorado-based recruiting and search firm, which has worked exclusively in the toxicology disciplines for over 30 years. We work with private sector employers who seek scientists/professionals with expertise in toxicology, pathology, risk assessment, and product safety. Product Categories: Career Advisors, Head Hunters Lhasa Limited 1635 Granary Wharf House, 2 Canal Wharf Leeds, W. Yorks, LS11 5PS United Kingdom Tel: 44 113.394.6020 Email: [email protected] Website: www.lhasalimited.org Lhasa Limited is a not-for-profit organization that facilitates collaborative data sharing projects in the pharmaceutical and chemistry- related industries. A pioneer in the production of knowledge based systems for forward thinking scientists, and producer of state of the art in silico prediction and database systems Derek Nexus: Predicting toxicity Sarah Nexus: Predicting mutagenicity Meteor Nexus: Predicting metabolic fate Zeneth: Predicting forced degradation pathways Vitic Nexus: Toxicity database. Product Categories: Computing Systems, Data Management, Education, QSAR (Quantitative Structure Activity Relationship) Modeling/Analysis, Software

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Litron Laboratories 1818 3500 Winton Place Rochester, NY 14623 United States Tel: 585.442.0930 Fax: 585.442.0934 Email: [email protected] Website: www.litronlabs.com Litron Laboratories is the world leader in genetox analysis via flow cytometry. Routinely used by pharmaceutical companies and EXHIBITOR DESCRIPTIONS EXHIBITOR CROs around the world, our In Vivo and In Vitro MicroFlow® kits provide state-of-the-art flow cytometric micronucleus (MN) analysis for a wide range of species and cell lines. As a valuable compliment to the In Vivo MN method, our MutaFlow® kits take advantage of fast, efficient flow cytometry for the detection of In Vivo mutations at the Pig-a gene. Product Categories: Genotoxicity Products/Services, High-Throughput Test Systems, In Vitro Research/Testing, In Vivo Research/ Testing, Pharmaceutical Product Safety/Toxicology Lomir Biomedical, Inc. 1819 95 Huot Notre-Dame-de-L’Ile-Perrot, QC J7V 7M4 Canada Tel: +514.425.3604 Toll Free: +877.425.3604 Fax: +514.425.3605 Email: [email protected] Website: www.lomir.com Lomir is the world’s largest manufacturer of animal jackets, infusion products and restrainers. Products include infusion systems, protective jackets restrainers, handling equipment and environmental enrichment, available for all laboratory animal species. Manufacturing capabilities complete with use of innovative raw materials enable Lomir to undertake custom production while retaining the same levels of customer service trusted for over 20 years. Visit us to discuss your requirements in detail. Product Categories: Animal Equipment, In Vivo Equipment/Supplies, Infusion Equipment, Pumps, Telemetry/Telepathology Lovelace Respiratory Research Institute (LRRI) 1602 2425 Ridgecrest Drive SE Albuquerque, NM 87108 United States Tel: 505.348.9456 Fax: 505.348.8542 Email: [email protected] Website: www.LRRI.org The Lovelace Respiratory Research Institute is a private nonprofit biomedical research organization. LRRI offers internationally- recognized expertise in aerosol science, medicinal aerosol delivery, inhalation exposure technology, respiratory-cardiovascular- infectious disease research, pharmacology models, inhalation toxicology, ADME/PK, CBRNE countermeasures and clinical trials. Studies are routinely performed under GLP standards. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Animal Models, Efficacy Testing, Inhalation Research/Testing, Pharmaceutical Product Safety/Toxicology

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Luxcel Biosciences, Ltd. 2227 Western Gateway Building, Office 204, UCC Cork Ireland Tel: +353 21 420 5348 Fax: +353 1 4811 801 Email: [email protected] Website: www.luxcel.com Assay kits for simple and convenient fluorescence-based, High-Throughput approach to the real-time analysis of Mitochondrial Respiration (OCR), Glycolysis (ECAR) and Intracellular Oxygen Concentration on a 96 or 384 well plate reader format. Measure cellular bioenergetics, Warburg and mitochondrial function, using whole cells, isolated mitochondria and 3D culture (spheroids, Raft, collagen and scaffolds) for cell biology and monitoring drug toxicity and function. Product Categories: Acute Toxicology Services/Testing, Cancer Biology/Carcinogenicity, Cardiology/Cardiotoxicology, In Vitro Metabolism, Preclinical Research/Testing Malvern Instruments 2213 117 Flanders Road Westborough, MA 01581 United States Tel: 508.768.6400 Email: [email protected] Website: www.nanosight.com Malvern supports better characterization/control of proteins/macromolecules. Charge, size, mass, molecular weight, polydispersity are critical parameters, measured using: NanoSight Nanoparticle Tracking Analysis, particle-by-particle characterization; Zetasizer, dynamic/static light scattering for size, molecular weight, protein charge; Viscotek SEC, molecular weight/structure; Viscosizer 200, particle size, concentration, formulation viscosity. Product Categories: Biomarkers, Biotechnology Products, Instruments, Pharmaceutical Formulations Marken 2016 4307 Emperor Boulevard, Suite 210 Durham, NC 27703 United States Tel: 240.417.4591 Email: [email protected] Website: www.marken.com Marken is a premium courier dedicated to life sciences. With over 30 year’s expertise in critical logistics and offices in 24 countries worldwide, we provide reliable supply chain management for biomedical research from early research and development through manufacturing and clinical trials. We provide global door-to-door solutions including customs/regulatory support and temperature control for shipment of preclinical and clinical biological specimens, drug product, medical devices, and small animal models. Product Categories: Animal Models, Biomedical Research Services, Nonclinical Research, Preclinical Research/Testing, Storage/ Biorepository Services

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Marshall BioResources 1018 5800 Lake Bluff Road 25 years or more ToxExpo Exhibitor North Rose, NY 14516 United States Tel: 315.587.2295 Fax: 315.587.2109 Email: [email protected] Website: www.marshallbio.com Marshall BioResources provides purpose-bred beagles, mongrels/hounds, Göttingen minipigs and ferrets for biomedical research. EXHIBITOR DESCRIPTIONS EXHIBITOR Marshall beagles are recognized worldwide as the leading canine toxicology model. Our dogs are healthy, well socialized, and uniform in size. They are bred and raised with genetic consistency in the US and China. The Göttingen minipig is the smallest available swine breed in North America and the animals are raised in a full-barrier environment. Product Categories: Animal Models Mary Ann Liebert, Inc. 1040 140 Huguenot Street New Rochelle, NY 10801 United States Tel: 914.740.2100 Email: [email protected] Website: www.liebertpub.com Applied In Vitro Toxicology, a new peer-reviewed journal, provides the latest research on the application of alternative in vitro testing methods for predicting adverse effects in the pharmaceutical, chemical, and personal care industries, and addresses the important issues facing the various chemical industries, including regulatory requirements; the reduction, refinement, and replacement of ; and the most appropriate methods for assessing safety and satisfying regulatory demands. Product Categories: Publishers, Research MatTek Corporation 620 200 Homer Avenue Ashland, MA 01721 United States Tel: 508.881.6771 Toll Free: 800.634.9018 Fax: 508.879.1532 Email: [email protected] Website: www.mattek.com MatTek Corporation is a world leader in the production of innovative 3D reconstructed human tissue models for toxicology, product development, safety and efficacy assessment, and target organ research applications. Our human cell-based in vitro models have provided superior biological relevance and reproducibility for the cosmetic, chemical, and pharmaceutical industries for over 20 years. Product Categories: Cells/Tissue, Chemical Product Safety/Toxicology, Consumer Product Safety/Toxicology, Cosmetic Product Safety/Toxicology, In Vitro Research/Testing

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MB Research Laboratories 1145 1765 Wentz Road Spinnerstown, PA 18968 United States Tel: 215.536.4110 Fax: 215.536.1816 Email: [email protected] Website: www.mbresearch.com MB Research Laboratories is a private CRO that has been conducting acute and subchronic toxicity studies since 1972. In addition to in vivo assays, MB is a leader in the field of alternative and in vitro toxicology with extensive experience in HET-CAM, BCOP, 3D Human Tissue Constructs/Equivalents, LLNA and Phototoxicity studies. MB is regularly inspected by the US EPA, US FDA, and USDA and has exemplary inspection records. Furthermore, we have been continuously accredited by AAALAC since 1975. Product Categories: Acute Toxicology Services/Testing, CRO—Contract Research Organization, In Vitro Research/Testing, In Vivo Research/Testing, Preclinical Research/Testing Medicilon Preclinical Research (Shanghai) LLC 1121 585 Chuanda Road, Chuansha Economic Park Shanghai, 201200 China Tel: 1.858.504.1256 Email: [email protected] Website: www.medicilon.com As one of the top drug discovery CRO in China, Medicilon provides fully integrated pharmaceutical services to the global pharmaceutical community. The services across chemistry, biology and structure biology, DMPK/PD, toxicology (GLP, non-GLP) services are specially designed to help clients develop their research and discovery programs from the initial idea stage to the IND filing phase. Product Categories: Biochemistry, CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, Pharmacokinetics, Preclinical Research/Testing Medicyte GmbH 1037 Im Neuenheimer Feld 581 Heidelberg, 69120 Germany Tel: +49 6221 72925 44 Email: [email protected] Website: www.medicyte.com Medicyte is combining large scale cell expansion with physiological relevance, thereby meeting the demand for high numbers of metabolic competent assay cells for screening and high-throughput applications, e.g. in ADMET or drug discovery. Medicyte provides assay-ready cells from various upcyted® human healthy or diseased tissues and optimized medium formulations but is also outlicensing its technology for the custom upcyting® of requested tissues. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Biotechnology Research/Testing, Cells/Tissue, Genotoxicity Products/Services, Preclinical Research/Testing

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Medline Industries, Inc. 929 One Medline Place Mundelein, IL 60060 United States Tel: 616.862.8030 Email: [email protected] Website: www.medline.com Medline Industries, Inc. is the largest privately held manufacturer and distributor of healthcare supplies in the United States, providing more than 350,000 products. As a $5.8 billion, privately-held enterprise, we manufacture and distribute solutions to animal research, EXHIBITOR DESCRIPTIONS EXHIBITOR contract research, pharmaceutical and medical device organizations. Our leading products include laboratory supplies, medical/ surgical products and a variety of PPE, including protective apparel, gloves and eyewear. Product Categories: Behavioral Testing/Equipment, Instruments, Product Development, Surgical Instruments, Tissue Equipment/ Research/Supplies Meso Scale Discovery 643 1601 Research Boulevard Rockville, MD 20886 United States Tel: 240.314.2795 Email: [email protected] Website: www.mesoscale.com Meso Scale Discovery (MSD®) is a leader in high performance, multiplex-enabled biomarker assays for cytokines, toxicology, neurodegeneration, and metabolic disease research, used by leading biopharmaceutical and academic researchers in human and animal model studies. MSD's proprietary electrochemiluminescence (ECL) platform delivers exceptional sensitivity, wide dynamic range and rapid turnaround. For more information email [email protected] or visit www.mesoscale.com. Product Categories: Biomarkers, Cardiology/Cardiotoxicology, Instruments, Pharmacokinetics, Preclinical Research/Testing MetaSystems Group, Inc. 513 70 Bridge street, Suite 100 Newton, MA 02458 United States Tel: 617.924.9950 Toll Free: 888.489.9959 Fax: 617.924.9954 Email: [email protected] Website: www.metasystems.org MetaSystems provides easy-to-use genetic imaging high-throughput slide scanning systems for clinical laboratories and biomedical research, fully automatic slide analysis platform Metafer, slide feeder, interphase spot counting, rare cell detection, metaphase search, tissue micro array analysis in fluorescence, brightfield. Ikaros: automatic karyotyping;Isis: FISH imaging. Isis options include: CGH, mFISH and high-resolution color banding analysis. MetaSystems also offers DNA probes and filters. Product Categories: Hematology, Histopathology, Pathology, Telemetry/Telepathology Mexican Society of Toxicology 638 Avenue Cafetales #1747, Colonia Haciendas de Coyoacán Mexico City, 04970 Mexico Tel: +(52) 55-57473310 Fax: +(52) 55-57473395 Email: [email protected] Website: www.somtox.com.mx SoMOTox will host the next International Congress of Toxicology to be held in Merida, Yucatan, Mexico in October 2016. We invite you to participate and to enjoy the city entrance to the Maya culture. Product Categories: International Organizations

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Michelson Prize and Grants in Reproductive Biology 2240 PO Box 66370 Los Angeles, CA 90066 United States Tel: 310.574.5780 Email: [email protected] Website: www.michelsonprizeandgrants.org The Michelson Prize and Grants provides international research grants of up to $750,000 to develop the first nonsurgical spay/ neuter method for male and female cats and dogs. The $25 million Michelson Prize will be awarded to the first entity to develop the successful product. For more information, visit www.michelsonprizeandgrants.org. Product Categories: Endocrinology Research/Testing, Immunology Research/Testing, Neurobiology/Neurotoxicology, Reproductive Toxicology, Research Microchip ID 1839 PO Box 1028 Lake Zurich, IL 60047 United States Tel: 847.387.0577 Email: [email protected] Website: www.microchipid.us “The Science of Laboratory Animal Identification” Microchip ID is dedicated to bring to the world’s Medical Research Industry the most cost-effective RFID technology. Utilizing our equipment to obtain a positive identification, in combination with our or your software, it is possible to track and record any aspect of your animals on study without errors. We can provide the end user with handheld and table top readers plus two sizes of implantable transponders ID100US 2x11mm, and ID100bUS 1.4x8mm. Product Categories: Animal Equipment, Animal Identification, Data Acquisition, Data Management, Preclinical Research/Testing MicroMatrices Associates Ltd 2017 Dundee University Incubator, James Lindsay Place Dundee, Angus DD15JJ United Kingdom Tel: +44(0)1382 322909 Email: [email protected] Website: www.micromatrices.com MicroMatrices is a specialist provider of mechanism-based safety assessment solutions to the pharmaceutical and chemical industries. Our products include problem solving services and technology for identification biomarkers that may be useful in classifying and risk assessing drugs and chemicals according to their mode of action. These products and services are of utmost relevance for product development and also for product rescue/repositioning. Product Categories: Biosensors, Microarrays, Pesticide Product Safety/Toxicology, Preclinical Research/Testing, Risk Assessment Millar, Inc. 1035 6001-A Gulf Freeway Houston, TX 77023 United States Tel: 832.667.7133 Toll Free: 800.667.2343 Fax: 713.714.8497 Email: [email protected] Website: www.millarinstruments.com At Millar, we are making the improbable possible by providing innovative solutions for chronic physiologic monitoring of cardiovascular, biopotential, neurological and tissue oxygenation data. Our wireless telemetry system enhances research with unparalleled signal quality and in-depth, highly accurate data, decreasing study time frames. The telemetry system also features unique rechargeable and reusable telemeters. Product Categories: Biosensors, Cardiology/Cardiotoxicology, Data Acquisition, In Vivo Research/Testing, Telemetry/ Telepathology

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Mimetas 2212 Booth Number: 2212 JH Oortweg 19 Leiden, 2333CH Netherlands Email: [email protected] Website: www.mimetas.com MIMETAS products are a unique combination of biotech and engineering. The best and unsurpassable model for testing new drugs is the human body. At MIMETAS we offer the second best model - it uses human cells, growing in three-dimensional structures, just EXHIBITOR DESCRIPTIONS EXHIBITOR as in our bodies. The cells are continuously perfused with growth medium, just as they are perfused with blood in our bodies. This wonderful invention is called the OrganoPlate™. Product Categories: Biotechnology Products, Biotechnology Research/Testing, Cells/Tissue Molecular Networks GmbH 1838 Henkestr. 91 Erlangen, 91052 Germany Tel: +49 9131 815668 Email: [email protected] Website: www.molecular-networks.com Molecular Networks (www.molecular-networks.com), creator of CORINA, PETRA and a leading cheminformatics company, now offers innovative approaches to predictive toxicology. Physicochemical properties, metabolic rules and chemotype alerts enable scientists to find analogs, profile compounds and understand toxicity in chemical discovery and safety and risk assessment. The product portfolio includes database and software products and customized solutions. Product Categories: Data Management, QSAR (Quantitative Structure Activity Relationship) Modeling/Analysis, Risk Assessment, Safety Assessment, Software Moltox 1309 PO Box 1189, 157 Industrial Park Drive Boone, NC 28607 United States Tel: 828.264.9099 Toll Free: 800.536.7232 Fax: 828.264.0103 Email: [email protected] Website: www.moltox.com Moltox is recognized worldwide as the leading manufacturer of quality products for genetic toxicology testing and research. Moltox products include the full range of materials needed to perform microbial mutagenicity assays including culture media, S9, strains, control chemicals and conventional and fluctuation test assay kits. Product Categories: Chemical Product Safety/Toxicology, Genotoxicity Products/Services, In Vitro Metabolism, Manufacturing- Custom

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Mouse Specifics Inc 619 2 Central Street, Level 01, Suite 01 Framingham, MA 01701 United States Tel: 617.571.8408 Email: [email protected] Website: www.mousespecifics.com Mouse Specifics, Inc. is a biotechnology company engaged in the development and commercialization of non-invasive high- throughput physiological assays for studying the effects of genes and drugs in mouse models of human disease. Our proprietary technology for rapidly screening targets in the cardiovascular and central nervous systems of conscious mice should accelerate development of drug therapies. Applications include study of mouse models of muscular dystrophy, ALS, and Down Syndrome. Product Categories: Cardiology/Cardiotoxicology, In Vivo Research/Testing, Neonatal/Pediatric Studies, Preclinical Research/ Testing, Product Development MPI Research 1801

54943 North Main Street ★ 2015 Platinum Level Supporter Mattawan, MI 49071 ▲ SOT Affiliate United States 25 years or more ToxExpo Exhibitor Tel: 269.668.3336 Fax: 269.668.4151 Please see our ad on the back cover. Email: [email protected] Website: www.mpiresearch.com MPI Research provides preclinical and clinical services to agricultural, environmental, biopharmaceutical, medical device, animal health, and chemical industries. MPI Research serves Sponsors through representatives in the United States, Europe, and Asia. Our recent achievements warrant a closer look to see how we've expanded to integrate the full spectrum of services for new drug and device candidates. For more information, visit www.mpiresearch.com Product Categories: Animal Models, Animal Use & Welfare, Biomarkers, CRO—Contract Research Organization, Developmental Toxicology, Efficacy Testing, GLP—Good Laboratory Practice Services, Histopathology, Neurobiology/Neurotoxicology, Nonclinical Research, Pathology, Pharmacology Preclinical Research/Testing, Reproductive Toxicology, Safety Assessment MRIGlobal 1543

425 Volker Boulevard ★ 2015 Silver Level Supporter Kansas City, MO 64110 25 years or more ToxExpo Exhibitor United States Tel: 816.753.7600 Fax: 816.753.8420 Email: [email protected] Website: www.mriglobal.org MRIGlobal, a not-for-profit research and development organization, delivers global solutions in national security and defense, energy and environment, life and animal sciences, agriculture and food safety, and transportation. The organization performs scientific research, advanced engineering and program integration, and management for clients in government, industry, and academia. Product Categories: Bioanalytical Services, Chemical Product Safety/Toxicology, Chemical Synthesis, CRO—Contract Research Organization, Toxicokinetics

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Multi Channel Systems 830 Aspenhaustrasse 21 Reutlingen, 72770 Germany Tel: +49 7121.909.2525 Email: [email protected] Website: www.alascience.com The main focus of Multi Channel Systems is the development of scientific measuring instrumentation and equipment for research groups at universities and for the pharmaceutical industry, in the field of electrophysiology. We provide solutions for extracellular EXHIBITOR DESCRIPTIONS EXHIBITOR recordings with microelectrode arrays in vitro, featuring recording systems from 1 to 96 wells. Being in the electrophysiology market for over 15 years, we are the experts for basic research as well as screening experiments with MEAs. Product Categories: Biotechnology Products, Data Acquisition, High-Throughput Test Systems, In Vitro Equipment/Supplies, In Vivo Equipment/Supplies MultiCASE Inc 1133 23811 Chagrin Boulevard, Suite 305 Beachwood, OH 44122 United States Tel: 216.314.1341 Fax: 216.831.3742 Email: [email protected] Website: www.multicase.com MultiCASE Inc offers most advanced in silico toxicology software and services. We develop and license state of the art predictive toxicology software, perform in silico toxicity evaluation of drug candidates, impurities, metabolites and reagents. Our products are used by regulatory agencies, pharma/chemical/cosmetic companies. High-quality consulting services are also provided. We can help in: Reducing drug development costs; Reducing animal usage for toxicity evaluations. Product Categories: Consulting Services, Genotoxicity Products/Services, QSAR (Quantitative Structure Activity Relationship) Modeling/Analysis, Safety Assessment, Software NAMSA 916 6750 Wales Road Northwood, OH 43619 United States Tel: 419.666.9455 Fax: 419.662.4802 Email: [email protected] Website: www.namsa.com Beyond Contract Research, NAMSA is a medical research organization speeding product development for medical devices, IVDs, regenerative medicine and combination products. Using its MRO™ approach, NAMSA plays an important role in translational research, applying its unique combination of disciplines to move client’s products “from bench to bedside” more rapidly. Product Categories: Clinical Pathology, Efficacy Testing, Medical Devices/Testing, Preclinical Research/Testing Nanion Technologies Inc. 819 675 US Highway 1 North Brunswick, NJ 08902 United States Tel: 732.543.0565 Email: [email protected] Website: www.naniontech.com ‘Inspired by scientists’ is the definitive essence which provides the basis of all Nanion products. Scientists work together with engineers and designers. In the case of the CardioExcyte®, is a high resolution device recording contractility in intact cardiomyocyte networks utilizing non-invasive impedance measurements. It is a fully automated device, recording from 96 wells at a time with embedded electronics and a sophisticated sensor technology integrated in the well-plate based consumables. Product Categories: Cardiology/Cardiotoxicology, Medical Devices/Testing, Neurobiology/Neurotoxicology, Safety Assessment

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nanoComposix 1717 4878 Ronson Court, Suite K San Diego, CA 92111 United States Tel: 858.565.4227 Fax: 619.330.2556 Email: [email protected] Website: www.nanocomposix.com nanoComposix specializes in the production of precisely engineered and highly characterized nanomaterials for toxicology research. Our Biopure nanoparticles are concentrated, free of residual reactants, sterile and endotoxin-free. Selected by the OECD, NIH, FDA, and NIST as nanotoxicology reference materials, each batch is guaranteed to meet your specifications. Visit us to hear more about our latest shaped materials: nanocubes, nanorods, nanoribbons, and nanoplates. Product Categories: Biomarkers, Chemical Synthesis, CRO—Contract Research Organization, Environmental Chemistry/Fate, Safety Assessment National Disease Research Interchange 842 1628 John F. Kennedy Boulevard, 8 Penn Center, 15th Floor Philadelphia, PA 19103 United States Tel: 215.557.7361 Toll Free: 800.222.7364 Email: [email protected] Website: www.ndriresource.org The National Disease Research Interchange (NDRI) is a 501(c)(3) not-for-profit, NIH-funded organization that provides project- driven human biospecimen service to academic and corporate scientists. NDRI has over 30 years of experience globally distributing human biospecimens for research. Our extensive recovery network has the expertise to provide anatomical structures, organs, and tissues with annotated data. Product Categories: Gene Expression, Tissue Equipment/Research/Supplies National Institute of Environmental Health Sciences (NIEHS) 2228

PO Box 12233, Mail Drop B2-02 ♦ 2015 Diamond Level Supporter Research Triangle Park, NC 27709 United States Tel: 919.541.3345 Email: [email protected] Website: www.niehs.nih.gov The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, is located in Research Triangle Park, North Carolina. Our mission is to discover how the environment affects people, in order to promote healthier lives. NIEHS is home to the National Toxicology Program (NTP). Product Categories: Environmental Health, Environmental Research/Services/Testing, Environmental Risk Assessment, Exposure Assessment, Government Organizations

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National Institute of Technology and Evaluation 2242 2-49-10 Nishihara, Shibuya-ku Tokyo, 151-0066 Japan Tel: +81-3-3481-1735 Email: [email protected] Website: www.nite.go.jp/index-e.html National Institute of Technology and Evaluation (NITE) is an Incorporated Administrative Agency in Japan for supporting economic and industrial administrations such as chemical management. NITE has developed Hazard Evaluation Support System (HESS) for EXHIBITOR DESCRIPTIONS EXHIBITOR supporting the evaluation of repeated dose toxicity by category approach, which was developed by a Japanese national project, and has released for free last year. In our booth, we will provide introduction of HESS and user support. Product Categories: Chemical Product Safety/Toxicology, Government Organizations, QSAR (Quantitative Structure Activity Relationship) Modeling/Analysis, Regulatory Services/Toxicology National Jewish Health 518 1400 Jackson Street Denver, CO 80206 United States Tel: 303.398.1303 Email: [email protected] Website: www.njlabs.org National Jewish Health Laboratories offer in vitro, preclinical and clinical testing under CAP/CLIA/ISO15189 and GLP compliance. With 1,200+ studies experience, we can assess complement and inflammation in a number of test systems including humans, NHP. Complement activation, cytokines, ADA, immune complex detection and functional immunology testing used to assess biologics, vaccines, antibodies, nanoparticles and oligonucleotides. We offer study design, data analysis and adversity assessment. Product Categories: Biotechnology Research/Testing, Clinical Toxicology/Testing, Immunology Research/Testing, Pharmaceutical Product Safety/Toxicology, Preclinical Research/Testing National Library of Medicine 2126 8600 Rockville Pike Bethesda, MD 20894 United States Tel: 888.346.3656 Email: [email protected] Website: www.tox.nlm.nih.gov The National Library of Medicine (NLM) Specialized Information Services Division (SIS) is responsible for information resources and services in toxicology, environmental health, chemistry, and other topics. This includes databases and special topics Web pages, with access to many of its resources online, as downloads, Smartphone apps, and/or as Web pages optimized for mobile devices. All are available for free. For more information visit www.nlm.nih.gov. Product Categories: Chemical Product Safety/Toxicology, Consumer Product Safety/Toxicology, Education, Environmental Health, Risk Assessment National Toxicology Program 2226 PO Box 12233 Research Triangle Park, NC 27709 United States Tel: 919.541.3419 Email: [email protected] Website: www.ntp.niehs.nih.gov The National Toxicology Program is a cooperative effort within the US Department of Health and Human Services established to coordinate toxicology research and testing activities, develop and validate improved testing methods, and provide information about potentially hazardous agents that can be used to make decisions that protect public health. Product Categories: Animal Use & Welfare, Environmental Health, High-Throughput Test Systems, In Vivo Research/Testing, Safety Assessment

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Nat’l Center for Toxicological Research 614 3900 NCTR Road Jefferson, AR 72079 United States Tel: 870.543.7884 Email: [email protected] Website: www.fda.gov The National Center for Toxicological Research (NCTR), is the only FDA center located outside the Washington, DC metropolitan area. The one-million square foot research campus in Jefferson, Arkansas plays a critical role in the missions of FDA and the Department of Health and Human Services to promote and protect public health. NCTR plays a critical role in FDA’s mission. The unique scientific expertise of NCTR is critical in supporting FDA product centers and their regulatory roles. Product Categories: Government Organizations, Regulatory Services/Toxicology Nature Publishing Group 2218 75 Varick Street New York, NY 10013 United States Tel: 212.726.9200 Website: www.nature.com The NPG portfolio combines the excellence of Nature, its associated research and review journals, and leading academic and society journals in the life, physical and clinical sciences. Open access options are offered through the academic and society journals, Nature Communications and through a new fully open access publication: Scientific Reports. Product Categories: Publishers NeuroScience Associates (NSA) 1444 10915 Lake Ridge Drive Knoxville, TN 37934 United States Tel: 865.966.1266 Toll Free: 866.341.8191 Fax: 540.341.8192 Email: [email protected] Website: www.nsalabs.com NeuroScience Associates (NSA) provides mass production neurohistology services utilizing proprietary MultiBrain® and MultiCord® technologies for safety and R&D studies. NSA specializes in design and execution of safety studies including GLP safety certifications, low-cost R&D safety screens and specialized protocols required by the US FDA such as NMDA receptor antagonist safety evaluations. NSA provides traditional histology staining, immunohistochemistry, and a variety of specialty stains. Product Categories: CRO—Contract Research Organization, High-Throughput Test Systems, Neurobiology/Neurotoxicology, Pharmaceutical Product Safety/Toxicology, Preclinical Research/Testing Noveprim Group Ltd. 943 Le Vallon Vieux Grand Port, Mauritius Mauritius Tel: 717.368.5649 Email: [email protected] Website: www.noveprimgroup.com Noveprim Group Ltd. was founded in 1990 as a reliable source of purpose-bred Cynomolgus Macaque from Mauritius. Today, Noveprim has established itself as a world reference primate breeder. With its state-of-the-art facilities in Mauritius and in Europe, Noveprim is committed to breeding high-quality, SPF macaque research models that meet or exceed the requirements of the biomedical industry. Product Categories: Animal Models, Biomedical Research Products, Primate Supplies/Testing

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• Ranked among the top 20134.478 IMPACT journals in toxicology FACTOR • Rapid online publication • Optional open access

For more information visit toxsci.oxfordjournals.org

Meet with Editor-in-Chief Gary W. Miller at the SOT Pavilion, Booth 526 Monday to Wednesday, 10:00 AM to 11:00 AM and 2:00 PM to 3:00 PM

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NSF International/Health Sciences 1108

789 N. Dixboro ★ 2015 Silver Level Supporter Ann Arbor, MI 48105 United States Tel: 734.585.6848 Email: [email protected] Website: www.pharmalytica.com NSF Health Sciences supports the analytical challenges of the pharmaceutical, biotechnology and medical device industries. Testing and expertise: Extractables/Leachables; Oligonucleotide and Aptamer Analysis; Clinical/Non-clinical Bioanalysis; Method Development/Validation and Stability Testing. NSF’s Applied Research Center advances public health in water, food, pharma, and sustainability through R&D; Testing; Consulting – Chemistry, Microbiology, Toxicology; and Human Health Risk Assessment. Product Categories: Bioanalytical Services, Consulting Services, GLP—Good Laboratory Practice Services, Medical Devices/ Testing, Risk Assessment Nucro-Technics Incorporated 1305 2000 Ellesmere Road, Unit #16 25 years or more ToxExpo Exhibitor Scarborough, ON M1H 2W4 Canada Tel: +416.438.6727 Fax: +416.438.3463 Email: [email protected] Website: www.nucro-technics.com Since 1970, Nucro-Technics has provided toxicology, PK, bioanalytical, method development/validation, genetox, and biomarker analysis services to the pharmaceutical, medical device, and biotech industries. Our experience working with a wide array of molecules, and our strong sponsor relationships, have earned us our reputation as the CRO-of-choice for many companies. We are AAALAC-accredited and have been inspected by both the FDA and Health Canada as well as the SCC for compliance to GLP. Product Categories: Bioanalytical Services, CRO—Contract Research Organization, Genotoxicity Products/Services, Preclinical Research/Testing, Toxicokinetics, Pharmacokinetics Oak Hill Genetics 934 21434 Oak Hill Road Ewing, IL 62836 United States Tel: 618.629.2692 Toll Free: 877.949.2620 Fax: 618.629.2128 Email: [email protected] Oak Hill Genetics is a family-owned and operated facility dedicated to providing high-quality animals for the research world. Oak Hill Genetics is a USDA Class A facility that provides domestic swine and large framed mongrel dogs. Our goal is to provide the research community with animals and service responsive to your needs. Product Categories: Animal Models

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Omni International 933 935C Cobb Place Boulevard Kennesaw, GA 30144 United States Tel: 678.324.3742 Toll Free: 800.776.4431 Fax: 770.421.0206 Email: [email protected] Website: www.omni-inc.com EXHIBITOR DESCRIPTIONS EXHIBITOR Omni International, Inc is a leading global manufacturer and distributor of laboratory homogenizers. Since 1956, the name Omni has been synonymous with laboratory homogenizers. Referenced in over 10,000 peer reviewed scientific articles, Omni International homogenizers can be found in laboratories worldwide and are counted on for years of trouble-free operation. Product Categories: High-Throughput Test Systems Organovo 637

6275 Nancy Ridge Drive, Suite 110 ▲ SOT Affiliate San Diego, CA 92121 United States Tel: 858.224.1005 Email: [email protected] Website: www.organovo.com Organovo designs and creates dynamic, multi-cellular, and functional human tissues for use in drug discovery and medical research utilizing proprietary 3D bioprinting technology. Our living human tissues are proven to function like native tissues and are made available through contract toxicity testing services, customized projects, and partnerships. Product Categories: Acute Toxicology Services/Testing, ADME (Absorption/Distribution/Metabolism/Excretion), Animal Models, In Vitro Metabolism, Pharmaceutical Product Safety/Toxicology OtoScience Labs 729 1225 Tendick Street Jacksonville, IL 62650 United States Tel: 760.310.4799 Email: [email protected] Website: www.otosciencelab.com/ OtoScience Labs conducts contract research on hearing loss and tinnitus (ototoxicity) in rats and mice. We use a patented system for the measurement of tinnitus and hearing loss to help pharmaceutical and biotech companies develop preventative and treatment strategies for these maladies. Our ototoxicity testing includes the following assays: Startle Hearing Loss, auditory brainstem response (ABR), otoacoustic emission (OAE), and cochleagrams. Product Categories: Behavioral Testing/Equipment, CRO—Contract Research Organization, Food Safety/Toxicology, Preclinical Research/Testing, Safety Assessment Otto Trading, Inc 2031 1921 Carnegie Ave Suite C Santa Ana, CA 92705 United States Tel: 714.540.5595 Email: [email protected] Website: www.irestmassager.com Manufacturer and distributor of hand-held portable digital massager, TENS unit. Product Categories: Environmental Health

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Oxford University Press 739 198 Madison Avenue Please see our ad on page 95. New York, NY 10016 United States Tel: 919.677.0977 Email: [email protected] Website: www.oup.com Oxford University Press publishes the official journal of the Society of Toxicology, Toxicological Sciences, which contains premier peer-reviewed, hypothesis-driven, original research articles in all areas of toxicology. Editor-in-Chief: Gary W. Miller. http://toxsci.oxfordjournals.org Product Categories: Publishers Pacific BioLabs 820 551 Linus Pauling Drive Hercules, CA 94547 United States Tel: 510.964.9000 Fax: 510.964.0551 Email: [email protected] Website: www.pacificbiolabs.com Pacific BioLabs offers GLP/cGMP testing services to the biopharmaceutical and medical device industries. Our services include general toxicology, PK/ADME, biocompatibility, potency bioassays, sterility assurance, analytical chemistry, and microbiology. Pacific BioLabs is AAALAC-accredited and ISO 9001:2008 certified. Product Categories: Acute Toxicology Services/Testing, CRO—Contract Research Organization, Pharmaceutical Product Safety/ Toxicology, Preclinical Research/Testing Partek Incorporated 1111 624 Trade Center Boulevard St. Louis, MO 63005 United States Tel: 314.878.2329 Fax: 314.275.8453 Email: [email protected] Website: www.partek.com Partek Incorporated develops intuitive software built on a foundation of superior statistics and advanced visualizations to enable biologists and bioinformaticists to discover biological meaning of next generation sequencing and microarray data. With streamlined analysis workflows for RNA-Seq, SmRNA-Seq, Targeted-Seq, Exome-Seq, and ChIP-Seq, our complete analysis solution takes you from alignment through pathways, making it the fastest way to biology. Partek, turning data into discovery®. Product Categories: Biotechnology Products, Data Management, Genomics Products, Software PDS Life Sciences 1634 100 Valley Road, Suite 204 25 years or more ToxExpo Exhibitor Mount Arlington, NJ 07856 United States Tel: 973.398.2800 Fax: 815.642.4287 Email: [email protected] Website: www.PDS-Preclinical.com PDS scientists and software specialists have built the premiere integrated data management software solution, ASCENTOS™. PDS' Ascentos makes it simple for scientists to conduct discovery, toxicology, pathology and safety assessment research. Ascentos was designed to seamlessly adjust to your laboratory workflow to streamline data management from study setup to final reporting. TranSEND™ is your all-encompassing solution to convert, harmonize and validate FDA mandated SEND data sets. Product Categories: Computing Systems, Data Acquisition, Data Management, Data Reporting Systems, Software

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Perceptive Instruments Ltd. 1404 St. Francis House, Olding Road Bury St Edmunds, Suffolk IP33 3TA United Kingdom Tel: +44 1284 765566 Fax: +44 1284 489318 Email: [email protected] Website: www.perceptive.co.uk Perceptive Instruments aim to help you improve the integration between data acquisition, auditing and reporting for your genetox EXHIBITOR DESCRIPTIONS EXHIBITOR assays. Our flagship products include Comet Assay IV, Sorcerer Colony Counter, Ames Study Manager and Cyto Study Manager. With over 20 years experience, we have always delivered highly effective GLP-compliant solutions along with excellent customer service. We have a reputation for quality and operate a quality management system to ISO 9001:2008 and ISO 90003:2004. Product Categories: Analytical Instruments, Data Acquisition, Data Management, Data Reporting Systems, Software Pfizer Worldwide Research and Development 1321

445 Eastern Point Road ♦ 2015 Diamond Level Supporter Groton, CT 06340 ▲ SOT Affiliate United States Tel: 860.441.8429 Email: [email protected] Website: www.pfizer.com Founded in 1849, Pfizer is the world’s premier biopharmaceutical company taking new approaches to better health. We discover, develop, and manufacture safe and effective quality products to treat and help prevent disease. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better healthcare and health system support. Product Categories: Biotechnology Research/Testing, Nonclinical Research, Pharmaceutical Formulations, Pharmaceutical Product Safety/Toxicology, Research Pharmaron 827 6 Venture Suite 250 Irvine, CA 92618 United States Tel: 949.788.0586 Fax: 949.788.9204 Email: [email protected] Website: www.pharmaron.com Pharmaron is the leading integrated R&D service provider in China offering services in chemistry, biology, DMPK, pharmacology, and GLP toxicology. Pharmaron’s AAALAC-accredited, US GLP-compliant toxicology facilities are the most advanced in China with an unparalleled track record in support of global regulatory filings. Pharmaron conducts acute, sub-chronic and chronic general toxicology and safety pharmacology studies for US, European, and Asian biotech and pharmaceutical clients. Product Categories: CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, Pathology, Pharmacology, Toxicokinetics

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PhenoVista Biosciences 2120 6197 Cornerstone Court #103 San Diego, CA 92121 United States Tel: 858.437.9650 Email: [email protected] Website: www.phenovista.com PhenoVista Biosciences is a niche CRO based in San Diego California that provides phenotypic assay development services. Our specialty is in listening to our customers and working with them to develop the most relevant and statistically robust assay possible, on budget and on schedule. We are passionate about enabling world-class biological research. Our greatest satisfaction comes from seeing the faces of our clients light up when they see their data! Come chat with us about your dream assay. Product Categories: Cancer Biology/Carcinogenicity, CRO—Contract Research Organization, Developmental Toxicology, Neurobiology/Neurotoxicology, Preclinical Research/Testing PhoenixBio Co., Ltd. 311 65 Broadway, Suite 403 New York, NY 10006 United States Tel: 212.379.6411 Fax: 212.379.6422 Email: [email protected] Website: www.phoenixbio.co.jp/en PhoenixBio Co., Ltd. is a Japanese company producing the PXB-Mouse® model, the world’s most widely used human liver chimeric mouse for DMPK and Toxicology with a liver up to 95% replaced by human hepatocytes. We use the model to provide high-quality in-house study services for drug discovery and development mostly in the field of DMPK/toxicology and hepatitis virology. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Animal Models, CRO—Contract Research Organization, Preclinical Research/Testing, Toxicogenomics Phylonix Pharmaceuticals Inc 1800 100 Inman Street Cambridge, MA 02139 United States Tel: 617.441.6700-301 Fax: 617.492.7921 Email: [email protected] Website: www.phylonix.com Phylonix is a biotechnology company focused on profiling drug toxicity and efficacy using zebrafish as a model organism. Key pathways are highly conserved. We have developed numerous disease models, including angiogenesis, apoptosis, xenotransplant, neuronal disorders, and heart diseases. Increase screening throughput using whole animal assays. Acute Toxicology Services/Testing, Animal Models, Cardiology/Cardiotoxicology, Chronic Toxicology, Preclinical Research/Testing

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PointCross Life Sciences 1242 1291 E Hillsdale Boulevard, Suite 304 Foster City, CA 94404 United States Tel: 360.790.8971 Toll Free: 866.468.1900 Fax: 650.350.1903 Email: [email protected] Website: www.pointcrosslifesciences.com EXHIBITOR DESCRIPTIONS EXHIBITOR PointCross Life Sciences offers technology and services for CDISC SEND Readiness and analytics and visualization of nonclinical data. Our product DSIMS is deployed at the FDA as NIMS, SDIS for safety signal detection across studies and species. Provide services for data standardization, standards compliance, data fitness and quality assurance to compare study report data to SEND datasets. We have standardized over 6000 studies for clients since 2008. Learn more at pointcrosslifesciences.com. Product Categories: Computing Systems, Consulting Services, Data Management, Data Reporting Systems, Software Poly Scientific R&D Corp. 321 70 Cleveland Avenue Bay Shore, NY 11706 United States Tel: 631.586.0400 Toll Free: 800.645.5825 Fax: 631.254.0618 Email: [email protected] Website: www.polyrnd.com Since 1969 Poly Scientific R&D Corp. has manufactured special stains and reagents used in histology, microbiology, cytology and clinical laboratories. Our products are made fresh to order with BSC certified stains and USP or ACS grade reagents ensuring you receive the highest quality and longest shelf life possible. In addition to our catalog items we will custom formulate and package according to your needs. Visit our website. It is user friendly and easy to navigate through. Product Categories: Clinical Pathology, Hematology, Manufacturing-Custom, Pathology, Pharmaceutical Product Safety/ Toxicology Porsolt 915 ZA de Glatigné Le Genest St Isle, 53 940 France Tel: +33 2 43 69 36 07 Fax: +33 2 43 68 04 00 Email: [email protected] Website: www.porsolt.com Porsolt, a long established, fully GLP compliant, preclinical CRO, has been providing efficacy evaluation and safety pharmacology services for almost 30 years, covering early screening thru regulatory submission. Porsolt provides physiopathological models in multiples species, customized procedures, and tailored solutions, (including in vitro assays and drug formulation analysis), for psychiatric and neurological disorders, pain, cardiac and vascular diseases, metabolic and eating disorders. Product Categories: CRO—Contract Research Organization, Efficacy Testing, Pharmacology, Preclinical Research/Testing, Safety Assessment

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Pre-Clinical Research Services, Inc. (PCRS) 1240 1512 Webster Court Fort Collins, CO 80524 United States Tel: 970.232.1122 Fax: 970.232.1126 Email: [email protected] Website: www.preclinicalresearch.com PCRS offers GLP and non-GLP preclinical services to support pharmacokinetics, pharmacology and toxicology studies and numerous surgical models. Our expertise in a wide range of purpose-bred and large animal species allows us to efficiently support drug and medical device development. We provide rapid startup times and turnaround to manage our clients’ needs. Product Categories: Acute Toxicology Services/Testing, Chronic Toxicology, GLP—Good Laboratory Practice Services, Medical Devices/Testing, Preclinical Research/Testing PreLabs 1707 33 West Chicago Avenue Oak Park, IL 60302 United States Tel: 708.613.6000 Fax: 708.613.6100 Email: [email protected] Website: www.PreLabs.com PreLabs is an innovative, cost-effective preclinical contract support organization operating within AAALAC-accredited programs since 1988. We have a proven reputation for delivering scientific expertise and operational excellence ranging from consultancy services to comprehensive NHP solutions. Our PrimGen division introduced Primates with Passports to exclusively support global NHP programs including: import, quarantine, genetics, sales and distribution, staging, logistics, and bioproducts. Product Categories: Animal Models, Biomedical Research Services, In Vivo Research/Testing, Preclinical Research/Testing Primate Products, Inc. 745

PO Box 1588 25 years or more ToxExpo Exhibitor Immokalee, FL 34143 United States Tel: 239.867.2020 Toll Free: 866.881.5444 Fax: 239.867.2030 Email: [email protected] Website: www.primateproducts.com Primate Products, Inc., (PPI) corporate mission is to develop and distribute products and services that enhance the conservation and care of nonhuman primates. Through its accomplishments to date, PPI products and services touch the lives of approximately 95% of nonhuman primates used in research. Product Categories: Animal Equipment, Animal Models, Caging, Primate Supplies/Testing, Surgical Services

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Product Safety Labs 1701

2394 Route 130 25 years or more ToxExpo Exhibitor Dayton, NJ 08810 United States Tel: 732.438.5100 Email: [email protected] Website: www.productsafetylabs.com For over 40 years Product Safety Labs (PSL) has been an industry leader in the conduct of studies for Toxicological Research and Analytical Chemistry to the Agrochemical, Dietary Supplement, Animal Health, Medical Device, Pharmaceutical and Household EXHIBITOR DESCRIPTIONS EXHIBITOR Product industries. Our facilities in the US are GLP compliant and AAALAC-accredited. PSL prides itself on its commitment to quality, offering competitive pricing and on-time reports delivered through its team of expert, professional staff. Product Categories: Chemical Product Safety/Toxicology, CRO—Contract Research Organization, Inhalation Research/Testing, Reproductive Toxicology Promega Corp 2319 2800 Woods Hollow Road Madison, WI 53711 United States Tel: 608.274.4330 Toll Free: 800.356.9526 Fax: 608.277.2601 Email: [email protected] Website: www.promega.com Promega Corporation designs and manufactures: cell-based assays that deliver more biologically relevant data for drug discovery, screening, and basic research applications including mechanistic toxicity, ADME, biologics bioassays, reporter technologies for cell signaling to protein interactions; novel protein function and analysis systems; manual to automated nucleic acid purification for research, biobanking and clinical applications; with custom assay design services and GMP capability. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Biotechnology Products, High-Throughput Test Systems, In Vitro Metabolism, Molecular Biology/Products/Synthesis Public Interest Incorporated Foundation Biosafety Research Center (BSRC) 420 582-2, Shioshinden Iwata, Shizuoka Japan Tel: +81-538-58-1266 Fax: +81-538-58-3586 Email: [email protected] Website: www.anpyo.or.jp To present the contents of research business of Biosafety Research Center (BSRC). Product Categories: Cancer Biology/Carcinogenicity, CRO—Contract Research Organization, Fish Toxicology, In Vitro Research/ Testing, In Vivo Research/Testing Purina LabDiet 1509 PO Box 19798 25 years or more ToxExpo Exhibitor St. Louis, MO 63144 United States Tel: 800.227.8941 Email: [email protected] Website: www.labdiet.com Purina Mills is the International supplier of the LabDiet® and TestDiet® products used in lab animal nutrition. All products are manufactured in our ISO9001:2008 Certified plant in Richmond, IN. Diets are available in Standard, Certified, Autoclavable, Irradiated, Vac-Pak and Micro-Pak. Custom diets are also available upon request. Product Categories: Animal Diets, Diet Formulation

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PWG Genetics 1102 15 Tech Park Crescent Singapore, 638117 Singapore Tel: +65 6863 3042 Fax: +65 6863 4834 Email: [email protected] Website: www.spfpig.com PWG Laboratories in Singapore offers unmatched preclinical research capabilities using its proprietary Micropig, NHPs and conventional animal models. OECD/US FDA GLP compliant study services in the area of drug and medical device development: toxicology/pharmacology, efficacy, bioanalysis and ISO10993 are offered. AAALAC-accredited animal facilities are also equipped with MRI, Micro-CT/PET, C-Arm and angiography enabling state-of-the-art imaging required for multi-disciplinary investigations. Product Categories: Animal Models, Biomedical Research Services, CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, Preclinical Research/Testing QIAGEN Bioinformatics 1201 1700 Seaport Boulevard, 3rd Floor 25 years or more ToxExpo Exhibitor Redwood City, MA 94063 United States Tel: 650.381.5100 Fax: 650.381.5190 Email: [email protected] Website: www.qiagen.com/ingenuity QIAGEN Redwood City, the company’s Center of Excellence in Biological Analysis and Interpretation, is a leading provider of biomedical information and analysis solutions for the exploration, interpretation and analysis of complex biological systems. Marketed under the Ingenuity brand, these innovative solutions are used by tens of thousands of researchers and clinicians at hundreds of leading institutions worldwide. Further information can be found at www.qiagen.com/ingenuity. Product Categories: Cancer Biology/Carcinogenicity, Gene Expression, Microarrays, Toxicogenomics QPS-THI 2029 Three Innovation Way, Suite 240 Newark, DE 19711 United States Tel: 302.690.4962 Fax: 302.369.5602 Email: [email protected] Website: www.qps-usa.com/default QPS is a GCP/GLP-compliant CRO that supports discovery, preclinical, and clinical drug development. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Bioanalytical Services, CRO—Contract Research Organization

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QTest Labs 1737 PO Box 12381 Columbus, OH 43212 United States Tel: 614.760.0800 Fax: 614.760.0900 Email: [email protected] Website: www.qtestlabs.com QTest Labs specializes in cardiovascular efficacy, safety, toxicology, and risk assessment of drugs and/or devices. Our aim is EXHIBITOR DESCRIPTIONS EXHIBITOR to minimize lead-time and cardiovascular risk, while increasing mechanistic understanding of a therapy. We provide in-depth cardiovascular consultation coupled with assessment paradigms that include a wide range of techniques, species, and preparations in both normal and clinically-relevant disease models in order to provide a rapid and comprehensive evaluation. Product Categories: Animal Models, Cardiology/Cardiotoxicology, CRO—Contract Research Organization, In Vivo Research/ Testing, Safety Assessment Qualyst Transporter Solutions 609 2810 Meridian Parkway, Suite 100 Durham, NC 27713 United States Tel: 919.313.6500 Email: [email protected] Website: www.qualyst.com Qualyst Transporter Solutions is the world’s only provider of hepatic drug transporter services and products utilizing an integrated cell system in a sandwich-culture. An integrated cell system is important because it is the only model in which hepatic transporters are expressed, localized and functioning comparable to in vivo conditions. This model allows for in vitro prediction of in vivo hepatic transporter based interactions. Product Categories: In Vitro Metabolism, In Vitro Research/Testing, Metabolism Studies, Pharmacokinetics Quidel 516 12544 High Bluff Drive, Suite #200 San Diego, CA 92130 United States Tel: 858.552.1100 Toll Free: 800.227.8855 Email: [email protected] Quidel is the option for all your research, biosafety, and cytotoxicity testing needs. Quidel offers products to meet biosafety testing and Complement dependent cytotoxicity testing needs, such as normal human sera, cobra venom factor and Complement fragment assays. MicroVue™ ELISA assays, depleted sera, proteins, monoclonal and polyclonal antibodies, antisera, antigens, controls, and special reagents are also available to round-out a comprehensive laboratory portfolio. Product Categories: Animal Models, Antibody Products, Biomedical Research Products, Preclinical Research/Testing, Research Quintiles 710 777 Oakmont Lane Suite #100 Westmont, IL 60559 United States Tel: 630.203.6231 Email: [email protected] Website: www.quintiles.com Quintiles (NYSE: Q), a Fortune 500 company, is the world’s largest provider of biopharmaceutical development and commercial outsourcing services. With a network of more than 30,000 employees conducting business in ~100 countries, we helped develop or commercialize all of 2013’s top-100 best-selling drugs on the market. Quintiles’ CardioCheck consists of a panel of in vitro assays that provide rapid insight into the cardiotoxic potential of drugs in the preclinical stage of development. Product Categories: Cardiology/Cardiotoxicology, Cells/Tissue, In Vitro Research/Testing, Preclinical Research/Testing, Safety Assessment

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Quotient Bioresearch 621 Metabolism and Chemistry Northamptonshire United Kingdom Tel: +44 7900 893 382 Fax: +44 1933 319990 Email: [email protected] Website: www.quotientbioresearch.com Quotient Bioresearch is a leading provider of services to agrochemical, animal health, biotechnology and pharmaceutical clients worldwide. We have the world’s largest dedicated custom radiolabelling group specializing in the synthesis of carbon-14 and tritium compounds together with an experienced group of metabolism scientists conducting both preclinical and clinical metabolism, metabolite identification and environmental fate studies to International Guidelines. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Environmental Chemistry/Fate, In Vitro Metabolism, In Vivo Metabolism, Metabolism Studies ReachBio 2326 123 NW 36th Street, Suite 235 Seattle, WA 98107 United States Tel: 206.420.0300 Toll Free: 877.838.2355 Fax: 206.420.0301 Email: [email protected] Website: www.reachbio.com ReachBio Research Labs (©ReachBio LLC) provides specialized contract research services and cell biology tools to the drug development and life science research communities. We utilize primary cell systems for more predictable and clinically relevant assays, impacting internal decision making. Our platform is broad and we can address cytokine storm risk, immunotoxicity, myelosuppression, cancer stem cell evaluation and much more supported with a variety of assays and in multiple species. Product Categories: Cancer Biology/Carcinogenicity, Cells/Tissue, CRO—Contract Research Organization, Hematology, Immunology Research/Testing, In Vitro Research/Testing, In Vivo Research/Testing, Preclinical Research/Testing, RegCheck 2330 25 DeForest Avenue Summit, NJ 07901 United States Tel: 908.273.8637 Fax: 908-273-2670 Email: [email protected] Website: www.myregcheck.com RegCheck™ provides a standardized, proven method for users to objectively evaluate study documentation and identify deficiencies with suggested corrective actions. RegCheck™ helps to avoid costly late-stage rework and potential delays by detecting potential issues that could prolong regulatory authorities’ review and approval. RegCheck™ is annotated to applicable 21 CFR and guidance documents. This easy to use tool can address multiple team objectives. Product Categories: Literature Searches, Nonclinical Research, Product Development, Regulatory Services/Toxicology, Software

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ReproCell 1143 51 Moulton Street Cambridge, MA 02138 United States Tel: 617.245.0000 Fax: 617.812.5900 Email: [email protected] Website: www.reprocell.com/en ReproCELL is an expanding global leader in providing researchers with integrated tools for translational research. ReproCELL, along EXHIBITOR DESCRIPTIONS EXHIBITOR with its Bioserve, Reinnervate and Stemgent brands offers a comprehensive suite of products and services from human biospecimen procurement to 3D cell culture, through cellular reprogramming and differentiation to readily-available differentiated cells. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Antibody Products, Cardiology/Cardiotoxicology, Cells/Tissue, In Vitro Equipment/Supplies Research Diets, Inc. 1027 20 Jules Lane New Brunswick, NJ 08901 United States Tel: 732.247.2390 Fax: 732.247.2340 Email: [email protected] Website: www.researchdiets.com Research Diets, Inc. formulates and produces purified OpenSource Diets® for laboratory animals. Custom diets shipped in 5-7 days. The BioDAQ® Food and Liquid Intake Monitor features spill-reducing hoppers, mounts to home cage, records the time, duration, amount of each meal automatically. Automated gate is programmable by time or amount consumed. Data is interpreted using powerful analysis software. Product Categories: Diet Formulation, In Vivo Metabolism, Animal Diets, Animal Equipment Reveal Biosciences 519 6195 Cornerstone Court East 110 San Diego, CA 92121 United States Tel: 858.274.3663 Email: [email protected] Website: www.revealbio.com Reveal Biosciences specializes in advanced tissue technologies as a service. Our fully automated facility and experienced scientists offer in situ hybridization (ISH), immunohistochemistry (IHC), image analysis (quantification) and digital pathology expertise. Our ISH technology combines a sensitive highly multiplexed mRNA assay with the power of ImageDx, our proprietary image analysis software, to provide quantitative ISH localization data from tissue samples. Product Categories: Biomarkers, CRO—Contract Research Organization, Histopathology, Pathology, Preclinical Research/Testing

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Ricerca Biosciences LLC 738 7528 Auburn Road 25 years or more ToxExpo Exhibitor Concord, OH 44077 United States Tel: 440.357.3151 Fax: 440.354.4415 Email: [email protected] Website: www.ricerca.com Ricerca offers integrated nonclinical services for drug candidate selection and development. Specialties include support in DMPK and toxicology screening, GLP drug safety and metabolism assessments (PK/TK, ADME, bioanalytical, safety pharmacology, and short-term to chronic toxicology studies). Our extensive profile of IND enabling pivotal studies support swift progression of your lead compounds into the clinic – streamlining your development process. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Agrochemical Product Safety/Toxicology, CRO— Contract Research Organization, In Vivo Metabolism, Regulatory Services/Toxicology Ridglan Farms, Inc 1303 PO Box 318 Mt. Horeb, WI 53572 United States Tel: 608.437.8670 Fax: 608.437.4731 Email: [email protected] Website: www.ridglan.com Ridglan Farms’ beagles are bred to be better and raised to be the best! Bordetella free animals available. New isolation facility ideal for conducting duration of immunity (DOI) studies and other studies. If you want top quality animals, unmatched customer service and delivery when you want it, then you are looking for Ridglan Farms. Contact us for all your beagle needs. Product Categories: Animal Models RightAnswer.com 1011 9538 Shenstone Drive Parker, CO 80134 United States Tel: 303.906.7711 Fax: 303.840.4846 Email: [email protected] Website: www.rightanswer.com RightAnswer provides quick and easy access to in-depth chemical and regulatory information on over 400,000 substances—a trusted one-stop resource for: Toxicology/Risk Assessment; EHS; Chemical Approvals; Incident Response; Regulatory Compliance; (M)SDS Authoring and Management; and Product Stewardship. Stop by booth 1011 to get a free 15-day trial. RightAnswer is also your trusted source for GHS labeling solutions, for day-to-day creation, use, and maintenance of critical shipping documents. Product Categories: Chemical Product Safety/Toxicology, Environmental Risk Assessment, Industrial Hygiene, Pharmaceutical Product Safety/Toxicology, Regulatory Services/Toxicology

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Rockland Immunochemicals, Inc. 2217 PO Box 5199 Limerick, PA 19468 United States Tel: 484.791.3823 Toll Free: 800.656.7625 Fax: 484.369.8654 Email: [email protected] Website: www.rockland-inc.com EXHIBITOR DESCRIPTIONS EXHIBITOR Rockland Immunochemicals supports the academic, biopharma and diagnostic industries with antibodies and antibody based tools™ for basic research, assay development and preclinical studies for over 50 years. Established in Pennsylvania, Rockland manufactures over 10,000 products for use in critical assays including western blotting, immunohistochemistry, immunofluorescence microscopy, ELISA and Flow cytometry. Product Categories: Antibody Products Royal Society of Chemistry, Cambridge 2143 Thomas Graham House, Science Park, Milton Road Cambridge, Cambridgeshire CB4 0WF United Kingdom Tel: +44 (0)1223 420066 Fax: +44 (0)1223 420247 Email: [email protected] Website: www.rsc.org The Royal Society of Chemistry is the world’s leading chemistry community, advancing excellence in the chemical sciences. Our diverse portfolio covers the breadth of the chemical and toxicological sciences in high-impact publications, including: • Toxicology Research: the journal for the best research in fundamental and applied aspects of toxicology • Issues in Toxicology Series: the suite of professional reference books on toxicological research and chemical exposure. Product Categories: Biomarkers, Communications, Education, Publishers, Research RTC, Research Toxicology Centre S.p.A. 718

Via Tito Speri, 12 ▲ SOT Affiliate Pomezia (Rome), 00040 Italy Tel: +(39) 331.606.8131 Fax: +(39) 06-910-5737 Email: [email protected] Website: www.rtc.it RTC leading CRO in Europe with 42 years of experience providing high-quality in nonclinical research to national and international pharmaceutical and chemical companies. RTC is accredited by AAALAC. RTC offers a full range of experimental services, performed by experts in the development of: Small molecules, biologicals, medical devices, veterinary drugs, food, chemicals, agrochemicals, and biocides. RTC high standard quality is guaranteed through European, American, and Japanese authorities’ approval. Product Categories: CRO—Contract Research Organization, Dermatotoxicology, Food Safety/Toxicology, Genotoxicity Products/ Services, Preclinical Research/Testing

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RTI International 814 3040 East Cornwallis Road Research Triangle Park, NC 27709 United States Tel: 919.541.6000 Email: [email protected] Website: www.rti.org/page.cfm/Dr RTI International is an independent nonprofit institute that provides research, development, and technical services for drug discovery and development, biochemical toxicology, nanotoxicology, ADME, bioanalytical chemistry, pharmacokinetics, metabolomics and proteomics, and neuropharmacology. RTI is the site of the the NIH-funded Eastern Regional Metabolomics Resource Core. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Bioanalytical Services, Biomarkers, Pharmacology, Pharmacokinetics SAGE Labs 618 2033 Westport Center Drive Saint Louis, MO 63146 United States Tel: 314.400.6616 Email: [email protected] Website: www.sageresearchlabs.com SAGE Labs, Horizon Discovery Group company, specializes in the custom design, development and characterization of unique, next- generation animal research models featuring specific gene deletions, insertions and modifications. We also provide extensive support services for researchers working with animal research models. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Animal Models, Transgenic Models Sarstedt Inc 421 1025 St. James Church Road Newton, NC 28658-0468 United States Tel: 828.465.4000 Toll Free: 800.257.5101 Fax: 828.465.4003 Email: [email protected] Website: www.sarstedt.com/php/main.php Sarstedt develops, manufactures, and markets laboratory equipment and consumables for medicine and research. Products include S-Monovette®, Multivette®, and Microvette® blood collection systems; a comprehensive range of cell culture labware including dishes, plates and flasks available in three surface options; and benchtop instruments including mixers, shakers and mini centrifuges. Product Categories: Biotechnology Products, Instruments, Medical Devices/Testing, Molecular Biology/Products/Synthesis, Tissue Equipment/Research/Supplies Science/AAAS 1015 1200 New York Avenue, NW Washington, DC 20005 United States Tel: 202.326.6417 Fax: 202.842.1065 Email: [email protected] Website: www.aaas.org Since 1848, AAAS and its members have worked together to advance science and serve society. As part of these efforts, AAAS publishes Science, a multidisciplinary peer-reviewed journal, and offers programs focused on science policy, international cooperation, science education, diversity, and career development for scientists. Product Categories: Career Advisors, Education, International Organizations, Organizations, Publishers

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SCIREQ, Inc. (Scientific Respiratory Equipment) 2020 6600 rue Street-Urbain, Suite 300 Montreal, QC H2S 3G8 Canada Tel: +877.572.4737 Fax: +514.286.1627 Email: [email protected] Website: www.scireq.com Together, SCIREQ and emka TECHNOLOGIES offer globally integrated solutions for physiology, pharmacology, and toxicology EXHIBITOR DESCRIPTIONS EXHIBITOR research. We provide a complete range of innovative instruments and services for in vivo and in vitro research. Our biomedical hardware and software combine accuracy and reproducibility to provide unparalleled insight into cardiovascular, respiratory and neurology studies, as cited in over 1,000 scientific publications. Visit our booth to discuss your research application! Product Categories: Inhalation Equipment, Inhalation Research/Testing, Preclinical Research/Testing, Pulmonary Equipment/ Research, Respiratory Toxicology Seahorse Bioscience 520 16 Esquire Road N. Billerica, MA 01862 United States Tel: 978.671.1600 Fax: 978.671.1611 Email: [email protected] Website: www.seahorsebio.com The XFe Analyzer and stress test kits measure cellular bioenergetics in real-time, simultaneously measuring mitochondrial respiration and glycolysis. The XFe sequentially delivers compounds via multiple drug ports to provide dose response, agonist or antagonist response, or pathway perturbation. By connecting genomic and proteomic data to physiologic traits of cells, the XFe provides greater understanding of in vitro toxicity and mitochondrial dysfunction in cancer, obesity, and other diseases. Product Categories: Analytical Instruments, Biotechnology Products, In Vitro Metabolism, Instruments, Metabolism Studies Sequani Limited 1527

Bromyard Road ▲ SOT Affiliate Ledbury, Herefordshire HR8 1LH 25 years or more ToxExpo Exhibitor United Kingdom Tel: +441.531.634121 Email: [email protected] Website: www.sequani.com Sequani a CRO with a 40 year heritage and a world-renowned reputation for non clinical toxicology in the drug development, crop protection and chemical safety industries. In a fast-moving, ever changing sector, our agility, creativity and unusually personal client relationships make all the difference. In other words, we offer better value for money. Everyone will tell you they try to build trust with their clients, but we really feel we’re getting it right. It’s what drives everything we do. Product Categories: Agrochemical Product Safety/Toxicology, Biomarkers, CRO—Contract Research Organization, Dermal Research/Testing, Histopathology, Pharmaceutical Product Safety/Toxicology, Preclinical Research/Testing, Safety Assessment, Toxicokinetics, Reproductive Toxicology

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Seventh Wave 1341 743 Spirit 40 Park Drive Chesterfield, MO 63005 United States Tel: 636.519.4885 Fax: 636.519.4886 Email: [email protected] Website: www.7thwavelabs.com Seventh Wave is a CRO specializing in preclinical drug development services including advisory services in toxicology and pathology, PK/TK/PD, pharmacology, and bioanalytical services. Services are provided to clients within the pharmaceutical, food and nutrition, biomedical device, agricultural, and chemical industries. GLP-related activities are comprised predominantly of gross and histopathology, pathology peer reviews and TK/PD data analysis in support of preclinical safety studies. Product Categories: Bioanalytical Services, Histopathology, Nonclinical Research, Pathology, Pharmacolog Shanghai InnoStar Biotech Co., Ltd (InnoStar) 1806 199 Guoshoujing Road, Zhangjiang HiTech Park, Pudong Shanghai, 201203 China Tel: +86-21-50800333 ext 117 Fax: +86-21-50801259 Email: [email protected] Website: www.ncdser.com Shanghai InnoStar (also named National Shanghai Center for New Drug Safety Evaluation and Research, NCDSER) is a GLP-certified CRO by CFDA, FDA and OECD. InnoStar provides non-clinical safety evaluation services including general, developmental, reproductive and genetic toxicology, safety pharmacology, pathology, clinical pathology, analysis/bioanalysis using rodents, rabbits, dogs and monkeys, etc., which meet or even exceed quality standards required by clients and regulatory authorities. Product Categories: Chronic Toxicology, Developmental Toxicology, Regulatory Services/Toxicology, Reproductive Toxicology Simulations Plus, Inc. 2312 42505 10th Street West Lancaster, CA 93534 United States Tel: 661.723.7723 Toll Free: 888.266.9294 Fax: 661.723.5524 Email: [email protected] Website: www.simulations-plus.com Simulations Plus GastroPlus™, DDDPlus™, MembranePlus™, ADMET Predictor™, MedChem Studio™, and MedChem Designer™ software are used in drug discovery and development for advanced data mining and molecule classification, de novo drug design, ADME-Tox property prediction (including “sites of metabolism” predictions), SAR model building, simulation of in vitro dissolution experiments and simulation of absorption/PBPK/PD and drug-drug interactions in humans and animals through various administration routes. Product Categories: Toxicokinetics, ADME (Absorption/Distribution/Metabolism/Excretion), Consulting Services, Modeling Products/Services, QSAR (Quantitative Structure Activity Relationship) Modeling/Analysis

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Sinclair Bio Resources 2035 PO Box 658 Columbia, MO 65205 United States Tel: 573.387.4400 Fax: 573.387.4404 Email: [email protected] Website: www.sinclairbioresources.com Sinclair BioResources is an AAALAC-accredited, USDA-inspected Miniature Swine producer offering four lineages; Yucatan, Micro EXHIBITOR DESCRIPTIONS EXHIBITOR Yucatan, Hanford and Sinclair. Sinclair is experienced in preshipping alterations including surgical alterations, preconditioning, and diabetes induction. Sinclair also has a thorough socialization program resulting in the most docile, easy to work with Miniature Swine available. Contact us with technical questions and experience our industry leading client service. Product Categories: Animal Models, Biomedical Research Products, Biomedical Research Services, In Vivo Research/Testing, Animal Diets Sinclair Research Center LLC 726 PO Box 658 Columbia, MO 65205 United States Tel: 573.387.4400 Fax: 573.387.4404 Email: [email protected] Website: www.sinclairresearch.com Toxicology: All species, acute to chronic studies, exploratory tox/efficacy and GLP IND enabling studies. Specialties: TK/PK/ADME, large animal studies including Dog, Miniature Swine and NHP, studies in diabetic Miniature Swine, Dogs and NHP, dermal, ocular, juvenile tox, 10993 Biocomp. Surgical Services: cardiovascular, orthopedic, wound healing, VAPs in large animals. Animal Models: Type I/II diabetes, obesity, atherosclerosis, osteoporosis, dermal, inflammation, and cardiovascular. Product Categories: Animal Models, GLP—Good Laboratory Practice Services, Medical Devices/Testing, Pharmacology, Preclinical Research/Testing Smithers 709

790 Main Street ★ 2015 Silver Level Supporter Wareham, MA 02571 25 years or more ToxExpo Exhibitor United States Tel: 508.295.2550 Fax: 508.295.8107 Email: [email protected] Website: www.smithers.com Smithers is a trusted provider of contract research services. Smithers Avanza Toxicology Services supports development through the identification of safety and/or efficacy outcomes. Our expertise includes single dose to two-year general toxicology studies, vaccine safety testing, and infusion studies. Smithers Viscient provides environmental testing and regulatory services, including ecotoxicology, environmental fate, metabolism, avian toxicology, chemistry, and endocrine disruptor testing. Product Categories: Acute Toxicology Services/Testing, Agrochemical Product Safety/Toxicology, CRO—Contract Research Organization, Developmental Toxicology, Ecology/Ecotoxicology Services, Environmental Chemistry/Fate, Environmental Research/Services/Testing, Environmental Risk Assessment, Metabolism Studies, Pharmaceutical Product Safety/Toxicology, Pharmacokinetics, Preclinical Research/Testing, Regulatory Services/Toxicology, Reproductive Toxicology, Toxicokinetics

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SNBL USA SRC 712 PO Box 1638 Alice, TX 78333 United States Tel: 361.664.8844 Email: [email protected] Website: www.snblusa.com SNBL USA offers a unique range of safety assessment services to fulfill its commitment to help free patients from suffering. Managed and operated by a team world renowned for its wide-ranging NHP expertise, SNBL USA offers programs ranging from regulatory tox to customized study designs in multiple drug classes (biologics, small molecules, oligonucleotides, and vaccines). Specialized capabilities include DART, radiation, apheresis, TBI, immunotoxicology, and carcinogenicity. Product Categories: Animal Models SNBL USA, Ltd. 1215

6605 Merrill Creek Parkway ▲ SOT Affiliate Everett, WA 98203 25 years or more ToxExpo Exhibitor United States Tel: 425.322.1950 Fax: 425.407.8601 Email: [email protected] Website: www.snblusa.com SNBL USA offers unique services to support drug development. Managed and operated by a team known for its extensive NHP experience and expertise, we facilitate programs ranging from regulatory toxicology to customized study designs and disease models. Specialized capabilities include biologics safety, repro tox, safety pharmacology, immunotoxicology, and carcinogenicity studies. SNBL USA can assure a quick study start with its in house colony and state of the art facility that can house approx 4000 NHPs. Product Categories: CRO—Contract Research Organization, Preclinical Research/Testing, Safety Assessment, Pharmacokinetics, Reproductive Toxicology SoBran Inc. 1029 4000 Blackburn Lane, Suite 100 Burtonsville, MD 20866 United States Tel: 301.648.3404 Fax: 301.476.9598 Email: [email protected] Website: www.sobranbioscience.com For over 12 years experts at SoBran have provided high-quality animal research and drug development services nationwide. We combine our in-house expertise with a network of world-class partners creating a fully integrated preclinical contract research network. We support a range of GLP and non-GLP compliant in vivo research at our AAALACi-accredited, ISO certified facility. We offer services for: • Drug development • Safety toxicology • ADME/PK • Animal model development and breeding services. Product Categories: Biomedical Research Services, CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, In Vivo Research/Testing, Preclinical Research/Testing

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Society of Quality Assurance (SQA) 1940 154 Hansen Road, Suite 201 Charlottesville, VA 22911 United States Tel: 434.297.4772 Fax: 434.977.1856 Email: [email protected] Website: www.sqa.org SQA is a membership society dedicated to advancing the principles and knowledge of quality assurance essential to human, animal, EXHIBITOR DESCRIPTIONS EXHIBITOR and environmental health. Members perform duties relating to quality assurance of non-clinical laboratory studies subject to the Good Laboratory Practice regulations of the US EPA and the US FDA; Clinical studies subject to Good Clinical Practice regulations of the FDA and International Conference on Harmonization; and Current Good Manufacturing Practices worldwide. Product Categories: Accreditation, Education, GLP—Good Laboratory Practice Services, International Organizations, Quality Assurance Society of Toxicology 526

1821 Michael Faraday Drive, Suite 300 ♦ 2015 Diamond Level Supporter Reston, VA 20190 25 years or more ToxExpo Exhibitor United States Tel: 703.438.3115 Fax: 703.438.3113 Email: [email protected] Website: www.toxicology.org The SOT Pavilion is your place to connect and learn about Society of Toxicology programs, services, membership benefits, and more. Find out about the SOT Endowment Fund; Toxicological Sciences, the official journal of the Society; SOT awards and fellowships; ToXchange, the SOT member network; educational programs directed across the spectrum from K–12 to throughout the toxicology career; the SOT on-site Job Bank; and everything taking place at the Annual Meeting. In addition to being a Wi-Fi hot spot, the SOT Pavilion has a bank of computers with Internet access for attendee use. Product Categories: Education, Organizations SOLVO Biotechnology 1732 111 Huntington Avenue Boston, MA 02199 United States Tel: 408.478.0150 Email: [email protected] Website: www.solvo.com Drug Transporter Services and Products from the Expert! With 14 years experience and 450 customers in 40 countries, SOLVO Biotechnology is the leading provider of transporter services and products. Leveraging our expertise in efflux and uptake transporters, we generate quality reports for submission to the FDA and the EMA. From small molecules to protein therapeutics, SOLVO can test all your transporter needs! For further information, please visit us at booth #1732. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), CRO—Contract Research Organization, Metabolism Studies, Pharmacokinetics, Research

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Sony Corporation 509 1-7-1 Konan Minato-ku Tokyo, 108-0075 Japan Tel: +81-3-6748-2536 Email: [email protected] Website: www.sony.co.jp/Products/LCI/products/si8000/index.html Sony exhibits a new imaging system suitable for the label-free characterization of cell movement. Based on the deep understanding of image processing technology, Sony developed an imaging platform for the quantification of various behaviors of cells. This system equips a high-speed camera, CO2-incubator, XYZ-scanning stage and specialized software, enabling quantitative assessment of cellular micro- and macro-movement. For further details, please visit Sony booth (#509) at SOT! Product Categories: Cancer Biology/Carcinogenicity, Cardiology/Cardiotoxicology, Image Capture Devices, In Vitro Research/ Testing, Neurobiology/Neurotoxicology Sophion Bioscience, Inc. 1844 Baltorpvej 154 DK-2750 Ballerup Denmark Tel: +454 460 8800 FAX: +454 460 8800 Email: [email protected] Website: www.biolinscientific.com/sophion Sophion, part of Biolin Scientific, introduced the world’s first automated patch clamp system, QPatch, in 2001 and it was launched commercially in 2004. Today systems can be found in a large number of laboratories worldwide. Our latest product, the Qube, have taken automated patch clamp to a new level. We now provide state-of-the-art automated patch clamp systems for medium to high- throughput offering compromised data quality in a user-friendly set up from assay development to data analysis. Product Categories: Cardiology/Cardiotoxicology, High-Throughput Test Systems, In Vitro Equipment/Supplies, Neurobiology/ Neurotoxicology, Safety Assessment Southern Research 1301

2000 9th Avenue South 25 years or more ToxExpo Exhibitor Birmingham, AL 35205 United States Tel: 205.504.1190 Toll Free: 888.322.1166 Fax: 205.581.2044 Email: [email protected] Website: www.southernresearch.org Southern Research is a science-driven, client-focused, preclinical contract research organization with over 50 years of experience in drug development. Services include efficacy testing, with special expertise in anti-cancer drugs and anti-infectives (anti-bacterial and anti-viral, supported by BSL-2 and BSL-3 laboratories and animal facilities) and a complete range of safety tests, including reproductive toxicology, with extensive bioanalytical, PCR and anatomic/clinical pathology facilities. Product Categories: Acute Toxicology Services/Testing, Developmental Toxicology, GLP—Good Laboratory Practice Services, Pharmaceutical Product Safety/Toxicology, Preclinical Research/Testing

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Springer 715 233 Spring Street New York, NY 10013 United States Tel: 212.460.1600 Toll Free: 800.777.4643 Fax: 212.460.1700 Email: [email protected] Website: www.springer.com EXHIBITOR DESCRIPTIONS EXHIBITOR Come browse current Springer Toxicology titles. Get 20% off print and eBooks. Learn about MyCopy editions: a printed eBook for $ 24.99 only. Springer, your partner in publishing. Meet our editors at the Springer booth to discuss your publishing proposal. Find all offers online at our website. Product Categories: Publishers SRI International 1126

333 Ravenswood Avenue ★ 2015 Silver Level Supporter Menlo Park, CA 94025 25 years or more ToxExpo Exhibitor United States Tel: 650.859.3000 Email: [email protected] Website: www.sri.com/biosciences SRI Biosciences provides our clients the discovery/ services necessary to advance drugs/biologics through IND-enabling studies. We offer tailored studies and turn-key programs with expertise in: target identification, lead discovery/ optimization, pharmacology, efficacy, PK/ADME, safety toxicology, formulation, cGMP manufacturing, regulatory strategy/IND preparation, and Phase I clinical trials. Let SRI be the solution to your discovery/development needs! Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, Pharmaceutical Product Safety/Toxicology, Pharmacokinetics STEMCELL Technologies Inc 1101 Suite 400 - 570 West 7th Avenue Vancouver, BC V5Z 1B3 Canada Tel: +800.667.0322 Fax: +800.567.2899 Email: [email protected] Website: www.stemcell.com STEMCELL Technologies Inc.’s Contract Assay Services (CAS) works with you to design and perform custom experiments. Our primary cell assays assess the effects of compounds on the proliferation and differentiation of hematopoietic, neural, mesenchymal and mammary stem cells. CAS will enhance your ability to determine the potency and safety of compounds earlier in drug development, saving time and resources. Since 2000, we have worked with over 120 academic and industrial organizations worldwide. Product Categories: Bone Biology/Toxicology, Hematology, In Vitro Research/Testing, In Vivo Research/Testing, Preclinical Research/Testing

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Stemina Biomarker Discovery, Inc. 1919 504 S. Rosa Road, Suite 150 Madison, WI 53719 United States Tel: 608.204.0104 Fax: 608.204.0107 Email: [email protected] Website: www.stemina.com Stemina Biomarker Discovery is a metabolomics company focused on the discovery, development and commercialization of molecular biomarkers to improve drug safety and human health. Stemina’s cell-based assays arise from the strategic convergence human embryonic stem (hES) cells and metabolomics. Stemina uses mass spectrometry to analyze the small molecules secreted by hES cells, differentiated cells made from hES cells, iPS cells, and cancer stem cells in response to drugs, injury or disease. Product Categories: Biomarkers, Cardiology/Cardiotoxicology, Developmental Toxicology, In Vivo Research/Testing, Safety Assessment Stillmeadow Inc 1418 12852 Park One Drive 25 years or more ToxExpo Exhibitor Sugar Land, TX 77478 United States Tel: 281.240.8828 Fax: 281.240.8448 Email: [email protected] Website: www.stillmeadow.com STILLMEADOW, INC. is a full-service CRO established in 1975. We are AAALAC, NELAP, and J-MAFF accredited. Testing includes toxicology, environmental toxicology, microbiology, entomology, chemistry and companion animal efficacy and safety studies. Complete information can be found on our website (www.stillmeadow.com). Product Categories: HPLC- High Pressure Liquid Chromatography, Inhalation Research/Testing, LC/MS-Liquid Chromatography/ Mass Spectroscopy Strand Life Sciences 642 548 Market Street San Francisco, CA 94104 United States Tel: 650.288.4735 Toll Free: 866.866.9326 Email: [email protected] Website: www.strandls.com Strand Life Sciences has pioneered the practice of scientific intelligence in life and health sciences. Leveraging its unmatched interdisciplinary scientific expertise with its decision support technologies, Strand empowers health and life sciences scientists to transform raw data into insights. Strand offers products and services for toxicologists, biologists and chemists that combine advanced visualization, predictive systems modeling, data integration and scientific context management. Product Categories: Acute Toxicology Services/Testing, In Vitro Research/Testing, Mechanistic Research/Testing, Safety Assessment

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Strategic Applications, Inc. (SAI) 1216 278 Park Avenue 25 years or more ToxExpo Exhibitor Lake Villa, IL 60046 United States Tel: 847.356.0321 Fax: 847.356.0382 Email: [email protected] Website: www.sai-infusion.com SAI is your comprehensive infusion and sampling, training and supply company. Our goal is to identify and provide the best possible EXHIBITOR DESCRIPTIONS EXHIBITOR tools and services to fit your scientific and budgetary needs. Our products include, Quick Connect infusion systems, Huber and blunt needles, custom designed catheters, access ports, ambulatory and stationary infusion pumps, software, jackets, harnesses, tethers and complete infusion systems for all species. Product Categories: Consulting Services, Infusion Equipment, Manufacturing-Custom, Pumps Suburban Surgical Company 1600

275 Twelfth Street 25 years or more ToxExpo Exhibitor Wheeling, IL 60090-2798 United States Tel: 847.537.9320 Toll Free: 800.323.7366 Fax: 847.537.9061 Email: [email protected] Website: www.suburbansurgical.com For 65+ years, Suburban Surgical Company has provided quality products and services for the research industry. We offer the finest stainless steel cages, and our primate cages are widely recognized for their excellence. We manufacture a variety of cages including: Avian, Cat, Dog, Rabbit, Rodent, Mouse and Guinea Pig and specialize in Isolation Cubicles, Racks, Carts, Pens, ICU and Tables including Operating, Exam, Lift and Prep-Procedure. All made in the USA. Product Categories: Animal Equipment, Caging, Manufacturing-Custom, Primate Supplies/Testing, Veterinary Product Development Syngene International Limited 836 Plot No. 2&3, Bommasandra IV Phase, Jigani Link Road Bangalore, Karnataka 560099 India Tel: +9180 2808 5453 Email: [email protected] Website: www.syngeneintl.com Syngene International Ltd. is India’s leading CRO and offers integrated discovery and development services with capabilities in medicinal chemistry, biology, in vivo pharmacology, toxicology, custom synthesis, process R&D and formulation development for small and large molecules. Syngene supports R&D programs from lead generation to clinical supplies. We are currently offering these services to over 70 clients globally. Our state-of-the-art research facilities. Product Categories: Nonclinical Research, CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, Manufacturing-Custom

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SynVivo 945 701 McMillian Way Huntsville, AL 35806 United States Tel: 256.726.4810 Email: [email protected] Website: www.synvivo.cfdrc.com SynVivo is a physiological, cell-based assay platform that provides a morphologically and biologically realistic microenvironment allowing real-time study of cellular behavior, drug delivery and drug discovery. Product Categories: Biotechnology Research/Testing, Cancer Biology/Carcinogenicity, In Vitro Research/Testing, Microfluidics, Neurobiology/Neurotoxicology Taconic 1142 One Hudson City Centre 25 years or more ToxExpo Exhibitor Hudson, NY 12534 United States Tel: 888.822.6642 Fax: 518.697.3905 Email: [email protected] Website: www.taconic.com Taconic, a leading provider of life sciences solutions to researchers worldwide, offers innovative animal models and scientific services for in vivo biomedical studies. Taconic’s wide range of advanced solutions include custom model design, generation and production, off-the-shelf model repositories, compound profiling, imaging, phenotyping, contract research, genetic monitoring and health testing. Product Categories: Animal Diets, Animal Models, In Vivo Research/Testing, Pharmaceutical Product Safety/Toxicology, Pharmacokinetics Takara Bio Europe AB 1009 Arvid Wallgrens Backe 20 Gothenburg, SE-41304 Sweden Tel: +46 31 7580957 Fax: +46 31 7580910 Email: [email protected] Website: www.cellartis.com Takara Bio Europe AB have highly reproducible iPSC and hESC derived hepatocytes and cardiomyocytes with significantly improved functionality ideal for ADMET, Safety Pharmacology and drug metabolism studies. Takara Bio Europe is a leader in stem cell technology and have robust and reproducible ways of controlling pluripotent stem cell production and differentiation. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Biomedical Research Products, Cardiology/ Cardiotoxicology, Genotoxicity Products/Services, Pharmaceutical Product Safety/Toxicology Tandem Labs 2014 1121 East 3900 South, Suite C-210 Salt Lake City, UT 84124 United States Tel: 801.293.2400 Fax: 801.313.6495 Email: [email protected] Website: www.tandemlabs.com Tandem Labs is a leading bioanalytical service provider with technology and services focused on supporting small and large-molecule development efforts for discovery, preclinical and clinical studies. We strive to differentiate ourselves with our scientific expertise, responsive project management staff, structured method development, on-time metrics, and strong regulatory history. Our menu includes GLP LC-MS/MS and immunoanalytical services, specialized testing, as well as biomarker services. Product Categories: Bioanalytical Services, Biomarkers, Biotechnology Research/Testing, CRO—Contract Research Organization, GLP—Good Laboratory Practice Services

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Tecniplast USA, Inc 2044 1345 Enterprise Drive West Chester, PA 19380 United States Tel: 484.947.7065 Email: [email protected] Website: www.tecniplastusa.com Tecniplast USA designs, manufactures, and installs innovative and top quality products for animal research laboratories of any size. Our offerings include housing systems for rodents and aquatics, changing stations, cage, bottle, and rack washing equipment, EXHIBITOR DESCRIPTIONS EXHIBITOR full or partial automation for clean and dirty sides; bedding disposal and dispensing systems with laminar flow technology, etc. For information, contact [email protected], Visit www.tecniplastusa.com, and/or Visit www.aquaticsolutionsusa.com Product Categories: Animal Equipment, Aquatic Sciences/Testing, Caging, Data Reporting Systems That’s Nice 2037 89 5th Avenue, 5th Floor New York, NY 10003 United States Tel: 212.366.4455 Email: [email protected] Website: thatsnice.com That’s Nice is a full-service agency providing research-driven brand management and marketing that enable businesses to achieve their goals. Our integrated services reflect 18 years of knowledge in life science and materials science markets, a passion for strategic thinking, and a comprehensive approach that meets the needs of global companies. Product Categories: Communications THINKY U.S.A., INC. 2111 23151 Verdugo Drive, Suite 107 Laguna Hills, CA 92653 United States Tel: 949.768.9001 Fax: 949.768.9003 Email: [email protected] Website: www.thinky-usa.com THINKY USA, Inc. NO BUBBLE MIXER: Mixes, disperses, and degasses materials (0.5g to 20kg) in minutes with/without the use of vacuum. Patented THINKY Mixers are used by 32,000 users worldwide for an extensive range of applications. Easy to clean up. NANO PULVERIZER: Pulverizes your materials to Nano-size “In Minutes” with very sharp particle size dispersion. Built-in Chiller contributes to sustain the Crystallinity of your materials. It disperses materials as well and it is easy to clean up. Product Categories: Biomedical Research Products, Instruments, Veterinary Product Development Three S Japan Co., Ltd. 2021 Segawaikebukuro building 301, 2-14-10 Minami-Ikebukuro Toshima-ku, Tokyo 171-0022 Japan Tel: +81 3 5911-7022 Fax: +81 3 5911-7028 Email: [email protected] Website: www.3sjapan.com Three S Japan Co., Ltd. is a group of professionals well versed in product development of drugs and other compounds, including nonclinical studies and clinical trials. Our business consists mainly of the following two services: 1. Preparation of various documents for application (CTD) of medicines and other compounds; 2. Accurate support to clients’ needs in developing medicines and other compounds by standing on a common ground with clients. Product Categories: Consulting Services, Consumer Product Safety/Toxicology, Cosmetic Product Safety/Toxicology, CRO— Contract Research Organization, Regulatory Services/Toxicology

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Tianjin Institute of Pharmaceutical Research 826 Huiren Avenue, 308, Binhai Science and Techolongy Park, Binhai High-Tech Zone Tianjin, 300301 China Tel: +86 138 205 74481 Fax: +022 848 45266 Email: [email protected] Website: www.tjipr.com/indexE.asp TJIPR the parental organization of Tianjin Center for Drug safety Assessment and Research (TDAR), was originally founded in 1959. TDAR is a state-owned high-tech pharmaceutical industry. As a CRO Company in China, the service provided covers preclinical safety evaluation, pharmacodnamic and pharmacokinetic study of new medical entity, biological products and other chemicals. As well, TDAR has been certified by GLP (SFDA) and accredited by AAALAC International. Product Categories: GLP—Good Laboratory Practice Services, Pharmacology, Regulatory Services/Toxicology, Safety Assessment, Pharmacokinetics TNO Triskelion 1921 Utrechtseweg 48, PO Box 844 Zeist, Utrecht 3700 AV Netherlands Tel: +31 88 866 16 28 Fax: +31 88 866 69 70 Email: [email protected] Website: www.triskelion.nl TNO Triskelion is a contract research organization active in toxicology research, analytical chemistry and chemical risk analyses. The mission of TNO Triskelion is to guarantee the quality and safety of food ingredients, chemical substances and medicines. TNO Triskelion is a subsidiary of TNO, the Netherlands Organisation for Applied Scientific Research. Product Categories: Chemical Product Safety/Toxicology, CRO—Contract Research Organization, Inhalation Research/Testing, Pharmaceutical Product Safety/Toxicology, Reproductive Toxicology TOXI-COOP Toxicological Research Center 1640 Magyar Jakobinusok tere 4/B Budapest, H-1122 Hungary Tel: +36 30 8462664 Fax: +36 87 481681 Email: [email protected] Website: www.trc.hu Toxi-Coop is a European CRO offering GLP, OECD, and FDA compliant preclinical in vivo and in vitro toxicology testing for food ingredients, chemicals (REACH), agrochemicals, pharmaceuticals, cosmetics, biocides, and medical devices. Our services include general toxicology (acute to carcinogenicity), genetic toxicology, reproductive toxicology, ecotoxicology, biotic/abiotic degradation, physico-chemical measurements meeting high standards for quality and timeliness at highly competitive pricing. Product Categories: Agrochemical Product Safety/Toxicology, Bioanalytical Services, Chemical Product Safety/Toxicology, Cosmetic Product Safety/Toxicology, CRO- Contract Research Organization, Ecology/Ecotoxicology Services, Endocrinology Research/Testing, Environmental Research/Services/Testing, Food Safety/Toxicology, Genotoxicity Products/Services, GLP- Good Laboratory Practice Services, In Vitro Research/Testing, In Vivo Research/Testing, Medical Devices/Testing, Pesticide Product Safety/Toxicology, Pharmaceutical Product Safety/Toxicology, Preclinical Research/Testing, Regulatory Services/Toxicology, Reproductive Toxicology, Toxicokinetics

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Toxicology Excellence for Risk Assessment (TERA) 2231

2300 Montana Avenue, Suite 409 ★ 2015 Gold Level Supporter Cincinnati, OH 45211 ▲ SOT Affiliate United States Tel: 513.542.7475 Fax: 513.542.7487 Email: [email protected] Website: www.tera.org Toxicology Excellence For Risk Assessment (TERA) is a non-profit risk assessment organization dedicated to the best use of toxicity EXHIBITOR DESCRIPTIONS EXHIBITOR information for risk assessment. Information on key TERA projects and resources will be available, including risk databases (ITER, RiskIE), training courses (Dose-Response Assessment Boot Camp), the KidsChemicalSafety.org, the Alliance for Risk Assessment, assessments, methods, peer review (ITERate), and the Occupational Alliance for Risk Assessment (OARS). Product Categories: Chemical Product Safety/Toxicology, Consulting Services, Consumer Product Safety/Toxicology, Environmental Risk Assessment, Risk Assessment Toxicology Regulatory Services (TRS) 1113 2365 Hunters Way Charlottesville, VA 22911 United States Tel: 434.977.5957 Fax: 434.977.0899 Email: [email protected] Website: www.toxregserv.com TRS provides scientific, regulatory and GLP QA consulting services for obtaining/maintaining worldwide approval of regulated and nonregulated products. Regulatory services: defining testing requirements; designing, implementing and monitoring toxicology, product chemistry, residue, e-fate and effects studies; interface with regulatory agencies; risk assessments. QA services: protocol reviews; data/report audits; facility inspections; GLP compliance program design. Product Categories: Consulting Services, GLP—Good Laboratory Practice Services, International Product Registration/Services, Quality Assurance, Regulatory Services/Toxicology Toxicology Research Laboratory (TRL) 1545 808 South Wood Street, Room 1306 Chicago, IL 60612 United States Tel: 312.996.9185 Fax: 312.996.7755 Email: [email protected] Website: www.uic.edu/labs/tox/tr The Toxicology Research Laboratory (TRL) has performed clinical and preclinical safety/toxicity and efficacy assessment of new drugs and chemicals for more than 25 years. TRL conducts GLP studies in rodents, rabbits, dogs, nonhuman primates and other species. TRL conducts efficacy studies in many models, including diabetes, mucositis, infection, acute radiation syndrome in mice and monkeys, etc. Bioanalytical and analytical support for toxicology, ADME and other studies are provided on-site. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Bioanalytical Services, Chemical Product Safety/ Toxicology, Efficacy Testing, Genotoxicity Products/Services

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Toxikon Corporation 1627 15 Wiggins Avenue 25 years or more ToxExpo Exhibitor Bedford, MA 01730 United States Tel: 800.458.4141 Email: [email protected] Website: www.toxikon.com Toxikon is an ISO/IEC 17025-accredited CRO registered with the FDA for drug, biologic, and medical device testing. Toxikon’s services include acute, subchronic, and chronic toxicity, reproductive toxicity, genetic toxicology, carcinogenicity, PK, TK, bioavailability, ADME, chemical characterization, impurities analysis and synthesis, bioanalysis, and microbiology. Additionally, full IND/NDA enabling studies are performed with a multidisciplinary approach to program management. Product Categories: Animal Models, Bioanalytical Services, CRO—Contract Research Organization, In Vitro Research/Testing, In Vivo Research/Testing ToxPlanet 2229 PO Box 1603 Cornelius, NC 28031 United States Tel: 704.896.7499 Email: [email protected] Website: www.toxplanet.com ToxPlanet launches this summer! Visit our booth, or register on toxplanet.com, and be among the first to learn about disruptive information solutions for the world of toxicology. Product Categories: Chemical Product Safety/Toxicology, Computing Systems, Literature Searches, MSDS (Material Safety Data Sheets) Management, Publishers ToxServices LLC 1911

1367 Connecticut Avenue, NW, Suite 300 ★ 2015 Platinum Level Supporter Washington, DC 20036 United States Tel: 202.429.8787 Fax: 202.429.8788 Email: [email protected] Website: www.toxservices.com ToxServices is a global provider of scientific-based consulting services that applies science to promote human health and environmental sustainability. ToxServices is a third-party profiler for the US EPA Design for the Environment (DfE) Safer Product Labeling Program, an authorized third-party profiler for GreenScreen™, and an accredited Cradle to Cradle® assessor. ToxServices provides clients with CleanGredients® evaluations, Health Product Declarations (HPD), and expert witness support. Product Categories: Consulting Services, Product Development, Regulatory Services/Toxicology, Risk Assessment, Safety Assessment ToxStrategies 732 9390 Research Boulevard, Suite 100 Austin, TX 78759 United States Tel: 512.382.9830 Email: [email protected] Website: www.toxstrategies.com ToxStrategies is a multidisciplinary scientific consulting firm that strives to develop innovative solutions to address the scientific, technical, and regulatory challenges confronting our clients. We have a reputation for applying sound science in all that we do, for thinking outside of the box, and for tailoring our approach to meet the specific needs of our clients, whether that need be for a rapid response or a comprehensive analysis. Product Categories: Consulting Services, Environmental Health, Food Safety/Toxicology, Industrial Hygiene, Risk Assessment

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Toxys 2214 Albinusdreef 2 Leiden, Zuid-Holland 2300 RC Netherlands Tel: +31 71 5269645 Email: [email protected] Website: www.toxys.com Toxys is an innovative Dutch CRO that provides next-generation genotoxicity testing services to rapidly identify potential carcinogenic properties of novel compounds during the early phases of product and drug development. Our ToxTracker assay is a EXHIBITOR DESCRIPTIONS EXHIBITOR state-of-the-art stem cell-based reporter system to identify various potentially carcinogenic properties of novel compounds with a superior sensitivity and specificity compared to conventional in vitro (geno) toxicity tests available on the market. Product Categories: Chemical Product Safety/Toxicology, CRO—Contract Research Organization, Genotoxicity Products/Services, In Vitro Research/Testing, Mechanistic Research/Testing TPL Pathology Labs R&D 1038, 1039 Sasbacherstraße 10 Freiburg, 79111 Germany Tel: +49 76 11203626 Email: [email protected] Website: www.tpl-pathology-labs.com TPL is your partner in Central Europe in histopathology services. TPL has continued to offer services in the field of human and toxicological pathology, target validation with microarrays and IHC techniques, epidemiological studies on human tissues, Xenograft tumor mouse model and cutting and grinding techn for implants. Product Categories: Antibody Products, Histopathology, Immunohistochemistry Research/Supplies, Preclinical Research/Testing, GLP—Good Laboratory Practice Services, Histopathology, Immunohistochemistry Research/Supplies, Preclinical Research/ Testing, Antibody Products, GLP—Good Laboratory Practice Services Translational Bioscience Inc. 639 428 Oakmead Parkway Sunnyvale, CA 94085 United States Tel: 408.475.2557 Email: [email protected] Website: www.translationalbioscience.com TransBio is a multidisciplinary CRO that caters expert solutions to pharma/biotech companies by offering preclinical and clinical toxicity screening utilizing primary human, primary animal and cell line culture models. We offer comprehensive safety screening services, mechanistic evaluation, a large portfolio of assays and novel assay development for evaluating toxicity in the liver, heart, kidney, bone marrow, immune system, skin, nervous system, adipose tissue and peripheral blood. Product Categories: Bone Biology/Toxicology, Cardiology/Cardiotoxicology, CRO—Contract Research Organization, Neurobiology/Neurotoxicology, Safety Assessment

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Trevigen Inc. 1810 8405 Helgerman Court Gaithersburg, MD 20877 United States Tel: 301.216.2800 Fax: 301.216.2801 Email: [email protected] Website: www.trevigen.com Trevigen, Inc. is focused on the development of products and technologies for cancer research, drug discovery, genetic toxicology, regenerative medicine and stem cell work. We offer kits and reagents for the study of DNA damage and repair, apoptosis, oxidative stress, cancer cell behavior, 3D culture, and stem cells. The company is the recipient of several SBIR grants from the National Institutes of Health. Product Categories: Biomedical Research Services, Biotechnology Research/Testing, Cancer Biology/Carcinogenicity, Genotoxicity Products/Services, Preclinical Research/Testing Triangle Research Labs, LLC 1736 6 Davis Drive, PO Box 14453 Research Triangle Park, NC 27709 United States Tel: 919.549.3587 Toll Free: 800.748.8979 Email: [email protected] Website: www.triangleresearchlabs.com Triangle Research Labs (TRL) produces high-quality hepatocytes for use in preclinical ADMETox applications. TRL provides both human and animal, fresh and cryopreserved hepatocytes, and their relevant media. Additionally, TRL distributes GenoMembrane Transporter Products and the Nexcelom CelloMeter Vision - HepatoMeter. TRL has decades of experience in the hepatic sciences and is a leader in quality and service in the business. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), In Vitro Metabolism, Metabolism Studies, Pharmaceutical Product Safety/Toxicology, Preclinical Research/Testing TSE Systems, Inc. 1927 186 Chesterfield Industrial Boulevard Chesterfield, MO 63005 United States Tel: 866.466.8873 Toll Free: 866.466.8873 Fax: 866.467.8873 Email: [email protected] Website: www.TSE-Systems.com Manufacturer of Sophisticated Life Science Research Instrumentation for in vivo and in vitro research since 1886. Experts for automated high-throughput systems for behavior, cardiovascular, inhalation and metabolism studies. Inhalation–PhenoMaster– IntelliCage–MotoRater–Multi Conditioning–Fish Behavior NEW: STELLAR Telemetry: Blood Pressure, Biopotentials, Temperature, Activity NanoSpectroPan: Easy measurement from nanoparticles up to microparticles E-Spray NanoGen: Twin-head electrospray system. Product Categories: Animal Equipment, Behavioral Testing/Equipment, Data Acquisition, Environmental Research/Services/ Testing, GLP- Good Laboratory Practice Services, In Vivo Metabolism, Inhalation Equipment, Preclinical Research/Testing, Surgical Services, Telemetry/Telepathology

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US Army Medical Research Institute of Chemical Defense (USAMRICD) 419 3100 Ricketts Point Road Aberdeen Proving Ground, MD 21010-5400 United States Tel: 410.436.3042 Email: [email protected] Website: www.usamricd.apgea.army.mil The US Army Medical Research Institute of Chemical Defense (USAMRICD) is the nation's leading science and technology lab in medical chemical countermeasures research and development. With sophisticated labs located at Aberdeen Proving Ground, MD, EXHIBITOR DESCRIPTIONS EXHIBITOR MRICD manages a diversified portfolio of medical chemical warfare agent research projects for the DoD and other Federal Agencies. MRICD is knowledgeable and experienced in all aspects of the operation of non-clinical research laboratory operations. Product Categories: Biochemistry, Government Organizations, In Vitro Research/Testing, In Vivo Research/Testing, Respiratory Toxicology US EPA/Office of Research and Development 2133 109 T.W. Alexander Drive Research Triangle Park, NC 27709 United States Tel: 919.541.7818 Fax: 919.541.0317 Email: [email protected] Website: www.epa.gov/ord Researchers at the US Environmental Protection Agency provide innovative and sustainable solutions to address today’s complex environmental problems and protect human health and the environment. Research focuses on the nation’s top environmental priorities: improve air quality; protect America’s waters; respond to climate change; assure chemical safety; clean up communities; provide support to homeland security and assess health risks to environmental contaminants. Visit, www.epa.gov/research. Product Categories: Environmental Health, Environmental Risk Assessment, Exposure Assessment, Government Organizations, Research Veritox, Inc. 1633 18372 Redmond-Fall City Road Redmond, WA 98052 United States Tel: 425.556.5555 Fax: 425.556.5556 Email: [email protected] Website: www.veritox.com Veritox’s board-certified experts in toxicology, industrial hygiene, and medical toxicology provide scientific advice and testimony for a diverse group of clients, including individuals, private and public corporations, governments (US and other), and non-governmental organizations. We offer expertise and consulting services in general, regulatory, medical, and forensic toxicology; birth defects; industrial hygiene; exposure assessment; and, environmental and occupational health. Product Categories: Chemical Product Safety/Toxicology, Chronic Toxicology, Consulting Services, Consumer Product Safety/ Toxicology, Developmental Toxicology, Engineering Services, Environmental Health, Expert Witness Services, Exposure Assessment, Industrial Hygiene, Literature Searches, Metal Toxicology, Pesticide Product Safety/Toxicology, Pharmaceutical Product Safety/Toxicology, Reproductive Toxicology, Respiratory Toxicology

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Vet Path Services (VPS) 1832 6450 Castle Drive Mason, OH 45040 United States Tel: 513.469.0777 Fax: 513.469.2474 Email: [email protected] Website: www.vetpathservicesinc.com Vet Path Services (VPS) is a GLP-compliant corporation providing contract pathology services (anatomic, clinical, and peer review), histology services (paraffin and plastic), and pathology specimen archiving services. VPS employs 9 highly-experienced board- certified (ACVP) pathologists, supporting standard toxicology, transgenic, and target animal safety studies. VPS supports clients in North America, Asia, and Europe. Product Categories: Archiving/GLP Compliant Archiving, Clinical Pathology, GLP—Good Laboratory Practice Services, Histopathology, Pathology Vimta Labs Limited 1939 Vimta Labs Limited, # 5 Alexandria Knowledge Park, Genome Valley, Turkapally Hyderabad, Andhra Pradesh 500078 India Tel: +91 40 6740 4125 Fax: +91 40 6740 4401 Email: [email protected] Website: www.vimta.com VIMTA is oriented to be the most efficient, reliable, and impeccable preclinical service provider. A highly dedicated pool of scientific talent, quality professionals, and support personnel is at the core of VIMTA's ability to deliver faster service to our clients. The team and the respective leaders are highly experienced and have significant working exposure in planning, execution and management of pharmacology, DMPK, safety pharmacology and toxicity projects for medical device, pharma and biotech industry. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Bioanalytical Services, Chronic Toxicology, Medical Devices/Testing, Preclinical Research/Testing Vitrocell Systems GmbH 1442 Fabrik Sonntag 3 Waldkirch, 79183 Germany Tel: +49 7681 497 79 50 Fax: +49 7681 497 79 79 Email: [email protected] Website: www.vitrocell.com VITROCELL® is specialised in the development of advanced in vitro exposure systems for inhalation toxicology: lung cells can be exposed to gases, environmental atmospheres, nano particles and complex mixtures at the air/liquid interface. VITROCELL® Skin modules and autosamplers are designed for the exposure of tissue. Our customers are leading research institutes, contract research organisations, regulatory authorities as well as the pharmaceutical and other industries throughout the world. Product Categories: Environmental Health, In Vitro Equipment/Supplies, In Vitro Metabolism, In Vitro Research/Testing, Inhalation Equipment, Instruments, Microfluidics, Pumps, Respiratory Toxicology, Tissue Equipment/Research/Supplies

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Vitron, Inc. 319 8320 S Wentworth Road 25 years or more ToxExpo Exhibitor Tucson, AZ 85747 United States Tel: 520.647.7411 Email: [email protected] Website: www.vitron.com Vitron develops and manufactures tissue slice research equipment and provides researchers with Brendel/Vitron tissue slicers, dynamic organ culture incubators, titanium and teflon roller inserts, and various other slice handling tools. Vitron is also a full- EXHIBITOR DESCRIPTIONS EXHIBITOR functioning in vitro contract laboratory specializing in conducting highly viable and fully functioning human precision-cut liver, kidney, lung, heart, and intestine slice experiments as well as animal liver, kidney and lung slices. Product Categories: Cells/Tissue, CRO—Contract Research Organization, In Vitro Equipment/Supplies, In Vitro Metabolism, In Vitro Research/Testing Vivo Bio Tech Limited 935 A1, 3 Floor, Surabhi Plaza, Vikrampuri Secunderabad, Telangana 500009 India Tel: +919.704.918555 Fax: +914.027.890669 Email: [email protected] Website: www.vivobio.com Vivo Bio Tech is a CRO offering wide array of drug discovery and development services in the areas – GLP/Non-GLP preclinical toxicology and pharmacology. The state-of-the-art 125,000 Sq.ft. ‘Preclinical Research Facility’ is GLP certified and AAALAC international-accredited. The company is the authorized breeder and distributor of Taconic Biosciences’ rodent models in India. Product Categories: Animal Models, CRO—Contract Research Organization, In Vitro Research/Testing, Pathology, Preclinical Research/Testing vivoPharm 1834 1214 Research Boulevard, Suite 1050 Hummelstown, PA 17036 United States Tel: 717.798.9990 Email: [email protected] Website: www.vivopharm.com vivoPharm is research organization that provides integrated preclinical services in various disease areas. We specialize in planning and conducting efficacy and toxicology studies studies to guide your drug development program, as needed for IND filings. We are transparent, flexible and reliable. vivoPharm guarantees short response times, consistency of service, regular up dates and transparency. vivoPharm is a GLP-compliant audited facility. Product Categories: Bioanalytical Services, CRO—Contract Research Organization, GLP—Good Laboratory Practice Services, In Vitro Research/Testing, In Vivo Research/Testing

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Vivotecnia 835 Santiago Grisolía 2 Tres Cantos, Madrid 28760 Spain Tel: +34917280713 Email: [email protected] Website: www. vivotecnia.com/home-page Vivotecnia is a non-clinical CRO that performs in vivo safety studies for pharmaceutical, biotech, chemical, agrochemical, cosmetic and tobacco companies all over the world. Our two main focuses are large animal studies (non-human primates, dogs, minipigs) and inhalation toxicology. Our inhalation facilities have a worldwide unique sealed glass exposure system. Besides toxicology studies in all species and administration routes, we conduct in vitro tests, efficacy and safety pharmacology studies. Product Categorise: CRO—Contract Research Organization, Inhalation Research/Testing, Nonclinical Research, Pharmaceutical Product Safety/Toxicology, Preclinical Research/Testing VRL Laboratories 2219 7540 Louis Pasteur, Suite 250 San Antonio, TX 78229 United States Tel: 210.615.7275 Fax: 210.615.7771 Email: [email protected] Website: www.vrl.net VRL is a proven leader of diagnostic testing services used and trusted worldwide. Our expertise has allowed us to now offer small animal testing. VRL will continue to deliver the same outstanding customer service, unmatched turn-around times and high-quality testing throughout our many testing platforms since 1988. Product Categories: GLP—Good Laboratory Practice Services, Microbiological Research/Testing, Primate Supplies/Testing, Research, Virology Research/Testing Wake Forest Innovations 941 200 East 1st Street - Box #2 Winston-Salem, NC 27101 United States Tel: 336.713.1591 Email: [email protected] Website: www.WakeForestInnovations.com Wake Forest Innovations establishes and manages new businesses and partnerships with industry, academia and government, based on the innovative products and services of Wake Forest Baptist Medical Center and Wake Forest University. Contract research and development services include: preclinical study development and management; clinical trial study development and management; core laboratory services; and applied training for health care practitioners. Product Categories: CRO—Contract Research Organization, Efficacy Testing, In Vivo Research/Testing. Nonclinical Research, Preclinical Research/Testing

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WestChina-Frontier PharmaTech Co., Ltd. (WCFP) 1135 28 Gaopeng Avenue, Hi-Tech Development Zone Chengdu, Sichuan 610041 China Tel: +86 138 8091 8590 Fax: +86 28 85125190 Email: [email protected] Website: www.frontierbsi.com WestChina-Frontier PharmaTech Co., Ltd (WCFP) is a first-class CRO in China. WCFP provide full-range preclinical services EXHIBITOR DESCRIPTIONS EXHIBITOR of drug efficacy and safety evaluation services (GLP and Non-GLP) including general, developmental, reproductive and genetic toxicology, safety pharmacology, carcinogenicity, pathology, analysis and efficacy service in nonhuman primates. With 26,000 m2 fully-operational facility accredited by AAALAC/OECD/CAP, WCFP has been serving its sponsors worldwide in preclinical research. Product Categories: CRO—Contract Research Organization, Efficacy Testing, Food Safety/Toxicology, Pharmaceutical Product Safety/Toxicology, Regulatory Services/Toxicology WIL Research 1019

1407 George Road ★ 2015 Contributor Level Supporter Ashland, OH 44805 ▲ SOT Affiliate United States 25 years or more ToxExpo Exhibitor Tel: 419.289.8700 Fax: 419.289.3650 Email: [email protected] Website: www.wilresearch.com WIL Research is a global CRO dedicated to listening to customer needs. The company custom designs product safety toxicological research, bioanalytical, and formulation services for pharmaceutical, biotechnology, chemical, agrochemical, and food companies, as well as manufacturing support for clinical trials. With approximately 1,100 dedicated scientific, technical, and support personnel located around the world, WIL Research offers technological expertise, flexible study design, and quality results. Product Categories: Bioanalytical Services, CRO—Contract Research Organization, Endocrinology Research/Testing, Pharmaceutical Formulations, Regulatory Services/Toxicology Wildlife International, a Division of EAG, Inc. 1531 8598 Commerce Drive 25 years or more ToxExpo Exhibitor Easton, MD 21601 United States Tel: 410.822.8600 Fax: 410.822.0632 Email: [email protected] Website: www.wildlifeinternational.com Wildlife International, PTRL-Europe and PTRL-West together from a Division of EAG, Inc.. We are a leading contract research organization (CRO) specializing in ecotoxicology, environmental fate, metabolism and chemistry. Since over 37 years, we serve and provide support to a global clientele with GLP-studies to meet global regulatory requirements for , pharmaceutical, animal health products, and industrial chemicals. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Agrochemical Product Safety/Toxicology, Ecology/ Ecotoxicology Services, Environmental Chemistry/Fate, In Vivo Metabolism

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World Precision Instruments 1114 175 Sarasota Center Boulevard Sarasota, FL 34240 United States Tel: 941.371.1003 Fax: 877.230.0162 Email: [email protected] Website: www.wpiinc.com World Precision Instruments, (WPI)-providing bioscience instruments to research scientists for over 40 years. We are a global supplier of microdissection instruments and associated small animal surgical products. Our diverse products lines include muscle physiology research, anesthesia, ventilators, syringe pumps, microinjection, stereotaxic frames, amplifiers, stimulators, isolators and micromanipulators. Product Categories: Infusion Equipment, Microdissection Instruments, Neurobiology/Neurotoxicology, Pumps, Surgical Instruments Worldwide Clinical Trials 2026 8609 Cross Park Drive Austin, TX 78754 United States Tel: 512.834.7766 Fax: 512.834.1165 Email: [email protected] Website: www.wwctrials.com Worldwide Clinical Trials provides full-service drug development services to the pharmaceutical industry. We can support you in your preregistration through peri-approval studies, but also specialize in bioanalytical and early phase development. This powerful combination of services ensures that you are working with a global CRO that can understand and meet the needs of your entire drug development program. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Bioanalytical Services, CRO—Contract Research Organization, Pharmacokinetics, Pharmacology Worldwide Primates, Inc. 1205 P O Box 971279 Miami, FL 33197 United States Tel: 305.378.9585 Fax: 305.232.3838 Email: [email protected] Website: www.wwprimates.com An importer, distributor and breeder of premium quality nonhuman primate models as well as nonhuman primate bio-products. We offer cynomolgus from multiple country origins, rhesus, Caribbean Green monkeys, marmosets, squirrel monkeys, and baboons. We have two facilities in the US, both CDC approved quarantine centers. We provide logistical support for transport, consulting, and delivery to clients. Please contact us for more information on our NHP models. Product Categories: Animal Equipment, Animal Models, Biomedical Research Products, Modeling Products/Services, Primate Supplies/Testing

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WuXi AppTec 1833 288 Fute Zhong Road, Waigaoqiao Free Trade Zone ♦ 2015 Diamond Level Supporter Shanghai, 200131 ▲ China SOT Affiliate Tel: +86 (21) 5046-1111 Toll Free: +1 888.794.0077 Fax: +86 (21) 5046-1000 Email: [email protected] Website: www.wuxiapptec.com EXHIBITOR DESCRIPTIONS EXHIBITOR WuXi AppTec offers a full-range of in vivo and in vitro preclinical safety evaluation studies as part of an integrated portfolio of cost- effective and efficient outsourcing solutions for drug and medical device discovery and development. Focusing on quality, flexibility and responsiveness, WuXi partners with Sponsors to provide comprehensive 501(k)/PMA/IND/NDA-enabling toxicology and laboratory services meeting global regulatory standards helping worldwide customers shorten time and lower costs for R&D. Product Categories: Bioanalytical Services, CRO—Contract Research Organization, Medical Devices/Testing, Preclinical Research/Testing, Safety Assessment Xenometrics 1703 17745 Metcalf Avenue Stillwell, KS 60685 United States Tel: 913.850.5000 Email: [email protected] Website: www.xenometricsllc.com Xenometrics, LLC, of Stilwell, Kansas, is a GLP compliant, USDA registered, AAALAC-accredited contract research organization, providing services to the pharmaceutical, biotech, companion animal health, and industrial- and agro-chemical industries. Xenometrics’ research species includes rodents, rabbits, minipigs, dogs, cats, nonhuman primates, and other research species. Xenometrics’ study services include: General Toxicology, and DART, Safety Pharmacology and DMPK. Product Categories: Developmental Toxicology, Nonclinical Research, ADME (Absorption/Distribution/Metabolism/Excretion), Chronic Toxicology, CRO—Contract Research Organization XenoTech, LLC 818 16825 W 116th Street Lenexa, KS 66219 United States Tel: 913.438.7450 Toll Free: 877.588.7530 Fax: 913.227.7100 Email: [email protected] Website: www.xenotechllc.com XenoTech is a global Contract Research Organization with unparalleled experience and expertise in evaluating drug candidates, nutraceuticals, cosmetics, food additives and other compounds widely known as xenobiotics, substrates, inhibitors and inducers of cytochrome P450, UGT and other drug metabolizing enzymes and drug transporters. The company offers a variety of in vitro and in vivo safety assessment studies for drug candidate evaluation as well as an extensive portfolio of in vitro products. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), CRO—Contract Research Organization, In Vitro Metabolism, In Vitro Research/Testing, Preclinical Research/Testing

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XpressBio 2336 PO BOX #458 Thurmont, MD 21788 United States Tel: 301.228.2444 Toll Free: 888.562.8914 Fax: 301.560.6570 Email: [email protected] Website: www.xpressbio.com XpressBio manufactures ELISA reagents for rodents, Simians, canines, and felines. Our Animal Health Monitoring ELISA products range from an array of assays such as MHV, MPV, PVM, RPV, ECUN, MAD, RHDV, to a very unique native mouse parvo ELISA kit, mouse and rat Pasteurella, and Helicobacter ELISA Kits. Our custom Multiplex ELISA assays are totally unique in the industry. We also manufacture Toxicity ELISA Assays as well as Vaccine Research Assays. Product Categories: Antibody Products, Genomics Products, Immunology Research/Testing, Primate Supplies/Testing, Virology Research/Testing Xybion Medical Systems 1608 201 Littleton Road Morris Plains, NJ 07950 United States Tel: 973.538.5111 Fax: 973.540.9712 Email: [email protected] Website: www.xybion.com Xybion is the global leader for preclinical, quality and compliance solutions for R&D organizations. Xybion’s Pristima® Suite is a comprehensive Research and Safety Study Management application. The fully integrated system offers advanced capabilities for pharmacology, toxicology and pathology data management. This unique solution delivers key functionality that integrate the business, animal management and scientific aspects of research studies. Visit Booth 1608 to learn more. Product Categories: Animal Use & Welfare, Computing Systems, Data Reporting Systems, Software Yecuris Corporation 913 PO Box 4645 Tualatin, OR 97062 United States Tel: 503.352.4663 Email: [email protected] Website: www.yecuris.com Yecuris is an Oregon based biotechnology company specialized in the development of novel tools and reagents for discovery and development. The FRG® KO mouse allows for the generation of models with humanized liver and immune systems. These models have proven useful in the assessment of drug metabolism, toxicity, infectious disease drug candidates. Additionally, high-quality human hepatocytes can be isolated from the models to be used in traditional in vitro assays including the MetAbArray™. Product Categories: Animal Models, Cells/Tissue, CRO—Contract Research Organization, Metabolism Studies, Transgenic Models

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Zoologix, Inc. 1642 9811 Owensmouth Avenue, Suite 4 Chatsworth, CA 91311 United States Tel: 818.717.8880 Fax: 818.717.8881 Email: [email protected] Website: www.zoologix.com Zoologix performs fast, sensitive, specific PCR and ELISA testing for infectious diseases of primates, rodents, dogs, cats, birds, EXHIBITOR DESCRIPTIONS EXHIBITOR amphibians, pigs, livestock, exotics and other research animals. Zoologix has more PCR tests for animals than any other source —see www.zoologix.com or phone us at 818.717.8880. Zoologix: The PCR Experts. Product Categories: Aquatic Sciences/Testing, Genomics Research/Testing, Veterinary Contract Laboratories, Virology Research/ Testing, Wildlife Testing Zyleris PharmaTech 1917 11 N. Skokie Hwy, Suite G-16 Lake Bluff, IL 60044 United States Tel: 847.604.8474 Email: [email protected] Website: www.zyleris.com High-Throughput Franz Cell Technology for Skin Absorption Screening Our technology was developed based on industry standard Franz Cell principle. It offers the best of both worlds—speed, cost-efficiency associated with high-throughput experimentation, and data compatibility with the Franz Cell technology. Services provided: 1. Skin absorption and penetration screening. 2. Corneal absorption and penetration screening. 3. Nail penetration screening. 4. Absorption depth profiling in stratum corneum. Product Categories: ADME (Absorption/Distribution/Metabolism/Excretion), Dermal Research/Testing, In Vitro Research/Testing, Pharmaceutical Formulations, Pharmacokinetics

Diamond Level Supporter Prize Drawing Win $500!

Drawings to take place on Monday, Tuesday, and Wednesday in the ToxExpo. $500 American Express Gift Card awarded each day. Drop your business cards in the ToxExpo prize drawing boxes found in all Diamond Level Exhibitor Supporter booths, see t on map. Booth Page ♦ Battelle 1727 36 ♦ Charles River 1326 45 ♦ National Institute of Environmental Health Sciences (NIEHS) 2228 92 ♦ Pfi zer Worldwide Research and Development 1321 99 ♦ SOT Endowment Fund, Society of Toxicology 526 115 ♦ WuXi AppTec 1833 133

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Accreditation International Institute for the Advancement of Medicine..... 1820 American Board of Toxicology (ABT)...... 1307 InvitroCue...... 2210 Society of Quality Assurance (SQA)...... 1940 Jai Research Foundation (JRF - America)...... 919 Lampire Biological Laboratories, Inc...... 1002 Acute Toxicology Services/Testing Lovelace Respiratory Research Institute (LRRI)...... 1602 Advinus Therapeutics Limited...... 2121 Medicyte GmbH...... 1037 ALCEDIAG...... 635 Organovo...... 637 BASi (Bioanalytical Systems, Inc)...... 1200 PhoenixBio Co., Ltd...... 311 BioPorto Diagnostics A/S...... 907 Promega Corp...... 2319 Charles River...... 1326 QPS-THI...... 2029 Comparative Biosciences (CBI)...... 737 Quotient Bioresearch...... 621 CATEGORICAL LISTING CATEGORICAL DV Biologics...... 1402 ReproCell...... 1143 INDIGO Biosciences, Inc...... 1006 Ricerca Biosciences LLC...... 738 Integrated Laboratory Systems, Inc. (ILS)...... 708 RTI International...... 814 Jai Research Foundation (JRF-America)...... 919 SAGE Labs...... 618 KAER Biotherapeutics...... 1841 Simulations Plus, Inc...... 2312 Luxcel Biosciences, Ltd...... 2227 SOLVO Biotechnology...... 1732 MB Research Laboratories...... 1145 SRI International...... 1126 Organovo...... 637 Takara Bio Europe AB...... 1009 Pacific BioLabs...... 820 Toxicology Research Laboratory (TRL)...... 1545 Phylonix Pharmaceuticals Inc...... 1800 Triangle Research Labs, LLC...... 1736 Pre-Clinical Research Services, Inc. (PCRS)...... 1240 Vimta Labs Limited...... 1939 Smithers...... 709 Wildlife International, a Division of EAG, Inc...... 1531 Southern Research...... 1301 Worldwide Clinical Trials...... 2026 Strand Life Sciences...... 642 Xenometrics...... 1703 ADME (Absorption/Distribution/ XenoTech, LLC...... 818 Metabolism/Excretion) Zyleris PharmaTech...... 1917 ABC Laboratories...... 1236 Agrochemical Product Safety/Toxicology Absorption Systems...... 309 Advinus Therapeutics Limited...... 2121 Accelera S.r.l...... 2220 BASF SE...... 2008 Advinus Therapeutics Limited...... 2121 Battelle...... 1727 AEgis Technologies Group...... 1000 Charles River...... 1326 Agena Bioscience...... 939 CiToxLAB...... 2327 Alliance Pharma...... 1207 Dermal Technology Laboratory Ltd...... 1637 Alturas Analytics, Inc...... 1802 Huntingdon Life Sciences/Harlan Laboratories...... 1515 Biopredic International...... 608 Integrated Laboratory Systems, Inc. (ILS)...... 708 BioreclamationIVT...... 1300 Ricerca Biosciences LLC...... 738 BioReliance...... 1313 Sequani Limited...... 1527 Calvert Laboratories, Inc...... 918 Smithers...... 709 Charles River...... 1326 TOXI-COOP Toxicological Research Center...... 1640 Dermal Technology Laboratory Ltd...... 1637 Wildlife International, a Division of EAG, Inc...... 1531 DV Biologics...... 1402 Enzo Life Sciences...... 1045 Analytical Instruments Epithelix...... 224 BMG LABTECH...... 1944 Eurofins Pharma Discovery Services...... 1319 Chilworth Technology Ltd...... 1734 Hurel Corporation...... 2116 Gyros...... 1044 In Vitro ADMET Laboratories (IVAL)...... 1420 Perceptive Instruments Ltd...... 1404 Integrated Analytical Solutions, Inc...... 733 Seahorse Bioscience...... 520

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Animal Diets Organovo...... 637 ClearH2O, Inc...... 1043 PhoenixBio Co., Ltd...... 311 Purina LabDiet...... 1509 Phylonix Pharmaceuticals Inc...... 1800 Research Diets, Inc...... 1027 PreLabs...... 1707 Sinclair Bio Resources...... 2035 Primate Products, Inc...... 745 Taconic...... 1142 PWG Genetics...... 1102 QTest Labs...... 1737 Animal Equipment Quidel...... 516 Aquaneering, Inc...... 1842 Ridglan Farms, Inc...... 1303 Carter2 Systems, Inc...... 2118 SAGE Labs...... 618 Datamars, Inc...... 613 Sinclair Bio Resources...... 2035 Instech Laboratories...... 1535 Sinclair Research Center LLC...... 726 Lab Products, Inc...... 1400 SNBL USA SRC...... 712 Lomir Biomedical, Inc...... 1819 Taconic...... 1142 Microchip ID...... 1839 The Jackson Laboratory...... 1107 Primate Products, Inc...... 745 Toxikon Corporation...... 1627 Research Diets, Inc...... 1027 Vivo Bio Tech Limited...... 935 Suburban Surgical Company...... 1600 Worldwide Primates, Inc...... 1205 Tecniplast USA, Inc...... 2044 Yecuris Corporation...... 913 TSE Systems, Inc...... 1927

Animal Use & Welfare CATEGORICAL LISTING Worldwide Primates, Inc...... 1205 Charles River...... 1326 Animal Husbandry Ellegaard Göttingen Minipigs A/S...... 1012 Ellegaard Göttingen Minipigs A/S...... 1012 MPI Research...... 1801 Elm Hill Breeding Labs, Inc...... 2027 National Toxicology Program...... 2226 Lab Products, Inc...... 1400 Xybion Medical Systems...... 1608 Animal Identification Antibody Products Bio Medic Data Systems, Inc...... 1501 Arbor Assays...... 2145 Datamars, Inc...... 613 BioPorto Diagnostics A/S...... 907 Microchip ID...... 1839 Cedarlane...... 1031 Animal Models Cosmo Bio USA, Inc...... 831 Alpha Genesis, Inc. (AGI)...... 900 Detroit R & D, Inc...... 821 Bioculture (Mauritius) Ltd...... 1028 eBioscience, An Affymetrix Company...... 832 Charles River...... 1326 EMD Millipore Corporation...... 408 Comparative Biosciences (CBI)...... 737 Genox Corporation...... 1210 Ellegaard Göttingen Minipigs A/S...... 1012 IntelliCyt Corporation...... 807 Elm Hill Breeding Labs, Inc...... 2027 Kingfisher Biotech...... 930 Exemplar Genetics...... 1013 Lampire Biological Laboratories, Inc...... 1002 Huntingdon Life Sciences/Harlan Laboratories...... 1515 Quidel...... 516 Integrated Laboratory Systems, Inc. (ILS)...... 708 ReproCell...... 1143 Kunming Biomed International (KBI)...... 1644 Rockland Immunochemicals, Inc...... 2217 Lovelace Respiratory Research Institute (LRRI)...... 1602 TPL Pathology Labs R&D...... 1038, 1039 Marken...... 2016 XpressBio...... 2336 Marshall BioResources...... 1018 Aquatic Sciences/Testing MPI Research...... 1801 ABC Laboratories...... 1236 Noveprim Group Ltd...... 943 Aquaneering, Inc...... 1842 Oak Hill Genetics...... 934 Charles River...... 1326

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Hamilton Thorne...... 1232 EMD Millipore Corporation...... 408 Tecniplast USA, Inc...... 2044 Enzo Life Sciences...... 1045 Zoologix, Inc...... 1642 Gene Tools LLC...... 2028 Archiving/GLP Compliant Archiving Medicilon Preclinical Research (Shanghai) LLC...... 1121 US Army Medical Research Institute of EPL Archives, Inc...... 1617 Chemical Defense (USAMRICD)...... 419 EPL, Inc...... 1619 Biomarkers Histo-Scientific Research Laboratories (HSRL)...... 1103 Vet Path Services (VPS)...... 1832 Alturas Analytics, Inc...... 1802 Ani Lytics, Inc...... 1720 Behavioral Testing/Equipment Arbor Assays...... 2145 BBD BIOPHENIX S.L. - BIOBIDE...... 313 BioPorto Diagnostics A/S...... 907 CATEGORICAL LISTING CATEGORICAL Charles River...... 1326 Charles River...... 1326 Clever Sys Inc...... 1138 Critical Path Institute...... 743 emka TECHNOLOGIES, INC...... 2018 Detroit R & D, Inc...... 821 Medline Industries, Inc...... 929 eBioscience, An Affymetrix Company...... 832 OtoScience Labs...... 729 EUROTOX 2015...... 636 TSE Systems, Inc...... 1927 Exiqon, Inc...... 317 Bioanalytical Services FlowMetric...... 828 ABC Laboratories...... 1236 Genox Corporation...... 1210 Absorption Systems...... 309 Gyros...... 1044 AI BioTech, LLC...... 1003 HTG Molecular Diagnostics...... 1208 Algorithme Pharma...... 1141 ICDD-sas...... 731 Alliance Pharma...... 1207 KCAS Bioanalytical Services...... 727 Alturas Analytics, Inc...... 1802 Kingfisher Biotech...... 930 BASi (Bioanalytical Systems, Inc)...... 1200 Malvern Instruments...... 2213 ChanTest Corp...... 901 Meso Scale Discovery...... 643 Charles River...... 1326 MPI Research...... 1801 Integrated Analytical Solutions, Inc...... 733 nanoComposix...... 1717 Intertek...... 2115 Reveal Biosciences...... 519 KCAS Bioanalytical Services...... 727 Royal Society of Chemistry, Cambridge...... 2143 MRIGlobal...... 1543 RTI International...... 814 NSF International/Health Sciences...... 1108 Sequani Limited...... 1527 Nucro-Technics Incorporated...... 1305 Stemina Biomarker Discovery, Inc...... 1919 QPS-THI...... 2029 Tandem Labs...... 2014 RTI International...... 814 Biomedical Research Products Seventh Wave...... 1341 Applied BioPhysics, Inc...... 1005 Tandem Labs...... 2014 Bio Medic Data Systems, Inc...... 1501 Toxicology Research Laboratory (TRL)...... 1545 BioreclamationIVT...... 1300 TOXI-COOP Toxicological Research Center...... 1640 Cayman Chemical...... 1001 Toxikon Corporation...... 1627 Cedarlane...... 1031 Vimta Labs Limited...... 1939 CH Technologies (USA), Inc...... 1440 vivoPharm...... 1834 DiaPharma Group, Inc...... 1938 WIL Research...... 1019 International Institute for the Advancement of Medicine..... 1820 Worldwide Clinical Trials...... 2026 Noveprim Group Ltd...... 943 Biochemistry Quidel...... 516 AI BioTech, LLC...... 1003 Sinclair Bio Resources...... 2035 Charles River...... 1326 Takara Bio Europe AB...... 1009

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THINKY U.S.A., INC...... 2111 National Jewish Health...... 518 Worldwide Primates, Inc...... 1205 Pfizer Worldwide Research and Development...... 1321 Biomedical Research Services SynVivo...... 945 Tandem Labs...... 2014 CH Technologies (USA), Inc...... 1440 Trevigen Inc...... 1810 Clever Sys Inc...... 1138 Marken...... 2016 Blood Pressure Accessories PreLabs...... 1707 Data Sciences International (DSI)...... 1918 PWG Genetics...... 1102 Bone Biology/Toxicology Sinclair Bio Resources...... 2035 Charles River...... 1326 SoBran Inc...... 1029 STEMCELL Technologies Inc...... 1101 Trevigen Inc...... 1810 Translational Bioscience Inc...... 639 Biosensors Caging MicroMatrices Associates Ltd...... 2017 Carter2 Systems, Inc...... 2118 Millar, Inc...... 1035 Lab Products, Inc...... 1400 Biotechnology Products Primate Products, Inc...... 745 ACEA Biosciences, Inc...... 906 Suburban Surgical Company...... 1600 Axion Biosystems, Inc...... 817 Tecniplast USA, Inc...... 2044 BioPorto Diagnostics A/S...... 907 Cancer Biology/Carcinogenicity Biosearch Technologies, Inc...... 2119 CATEGORICAL LISTING Agena Bioscience...... 939 BioSpyder Technologies...... 2233 Cayman Chemical...... 1001 Cedarlane...... 1031 Charles River...... 1326 ClearH2O, Inc...... 1043 Cosmo Bio USA, Inc...... 831 DiscoveRx...... 2316 Epithelix...... 1244 EMD Millipore Corporation...... 408 InSphero Inc...... 2318 Gene Tools LLC...... 2028 Jai Research Foundation (JRF - America)...... 919 Kingfisher Biotech...... 930 Luxcel Biosciences, Ltd...... 2227 Malvern Instruments...... 2213 PhenoVista Biosciences...... 2120 Mimetas...... 2212 Public Interest Incorporated Foundation Multi Channel Systems...... 830 Biosafety Research Center(BSRC)...... 420 Partek Incorporated...... 1111 QIAGEN Bioinformatics...... 1201 Promega Corp...... 2319 ReachBio...... 2326 Sarstedt Inc...... 421 Sony Corporation...... 509 Seahorse Bioscience...... 520 SynVivo...... 945 Biotechnology Research/Testing Trevigen Inc...... 1810 Aptuit LLC...... 719 Cardiology/Cardiotoxicology Axion Biosystems, Inc...... 817 Axiogenesis...... 903 Cellular Dynamics International, Inc...... 801 BBD BIOPHENIX S.L. - BIOBIDE...... 313 Charles River...... 1326 Charles River...... 1326 Chemical Solutions Ltd...... 1718 CorDynamics...... 1206 EMD Millipore Corporation...... 408 DV Biologics...... 1402 Genentech...... 1032 ECGVET, LLC...... 1100 HemoGenix Inc...... 1109 emka TECHNOLOGIES, INC...... 2018 ITR Canada (Bozo & ITR Group)...... 1827 Luxcel Biosciences, Ltd...... 2227 Kallistem...... 2332 Meso Scale Discovery...... 643 Medicyte GmbH...... 1037 Millar, Inc...... 1035 Mimetas...... 2212

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Mouse Specifics Inc...... 619 CXR Biosciences Limited...... 1715 Nanion Technologies Inc...... 819 Enzo Life Sciences...... 1045 Phylonix Pharmaceuticals Inc...... 1800 Huntingdon Life Sciences/Harlan Laboratories...... 1515 QTest Labs...... 1737 ICF International...... 2128 Quintiles...... 710 Institute for In Vitro Sciences, Inc...... 1026 ReproCell...... 1143 Kallistem...... 2332 Sony Corporation...... 509 MatTek Corporation...... 620 Sophion Bioscience, Inc...... 1844 Moltox...... 1309 Stemina Biomarker Discovery, Inc...... 1919 MRIGlobal...... 1543 Takara Bio Europe AB...... 1009 National Institute of Technology and Evaluation...... 2242 Translational Bioscience Inc...... 639 National Library of Medicine...... 2126 CATEGORICAL LISTING CATEGORICAL Career Advisors Product Safety Labs...... 1701 RightAnswer.com...... 1011 Leyden Group...... 1814 TNO Triskelion...... 1921 Science/AAAS...... 1015 Toxicology Excellence for Risk Assessment (TERA)...... 2231 Cells/Tissue Toxicology Research Laboratory (TRL)...... 1545 Alpha Genesis, Inc. (AGI)...... 900 TOXI-COOP Toxicological Research Center...... 1640 ArunA Biomedical, Inc...... 2237 ToxPlanet...... 2229 Axiogenesis...... 903 Toxys...... 2214 Bioculture (Mauritius) Ltd...... 1028 Veritox, Inc...... 1633 Biopredic International...... 608 Chemical Synthesis BioreclamationIVT...... 1300 ABC Laboratories...... 1236 Biosearch Technologies, Inc...... 2119 Biosearch Technologies, Inc...... 2119 CellSystems GmbH...... 1845 MRIGlobal...... 1543 Cellular Dynamics International, Inc...... 801 nanoComposix...... 1717 Charles River...... 1326 Cosmo Bio USA, Inc...... 831 Chromatography Products DV Biologics...... 1402 LabLogic Systems, Ltd...... 1212 emka TECHNOLOGIES, INC...... 2018 Chronic Toxicology Epithelix...... 1244 Alpha MED Scientific Inc...... 2211 FlowMetric...... 828 BASi (Bioanalytical Systems, Inc)...... 1200 Hurel Corporation...... 2116 Charles River...... 1326 International Institute for the Advancement of Medicine..... 1820 Experimur...... 1915 InvitroCue...... 2210 Jai Research Foundation (JRF - America)...... 919 MatTek Corporation...... 620 Phylonix Pharmaceuticals Inc...... 1800 Medicyte GmbH...... 1037 Pre-Clinical Research Services, Inc. (PCRS)...... 1240 Mimetas...... 2212 Shanghai InnoStar Biotech Co., Ltd (InnoStar)...... 1806 Quintiles...... 710 Veritox, Inc...... 1633 ReachBio...... 2326 Vimta Labs Limited...... 1939 ReproCell...... 1143 Xenometrics...... 1703 Vitron, Inc...... 319 Yecuris Corporation...... 913 Clinical Chemistry/Laboratory Analysis Chemical Product Safety/Toxicology Ani Lytics, Inc...... 1720 Antech Diagnostics GLP...... 1304 BASF SE...... 2008 Charles River...... 1326 BSL BIOSERVICE Scientific Laboratories GmbH...... 837 Genox Corporation...... 1210 Charles River...... 1326 IDEXX Laboratories, Inc...... 1112 CTEH®...... 1136

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Clinical Pathology Three S Japan Co., Ltd...... 2021 Antech Diagnostics GLP...... 1304 Toxicology Excellence for Risk Assessment (TERA)...... 2231 Charles River...... 1326 Toxicology Regulatory Services (TRS)...... 1113 NAMSA...... 916 ToxServices LLC...... 1911 Poly Scientific R&D Corp...... 321 ToxStrategies...... 732 Vet Path Services (VPS)...... 1832 Veritox, Inc...... 1633 Clinical Toxicology/Testing Consumer Product Safety/Toxicology American College of Veterinary Ophthalmologists...... 2141 BioReliance...... 1313 American Screening...... 2113 Cardno ChemRisk & Cardno...... 627 Asterand Bioscience...... 1008 Charles River...... 1326 Chemical Solutions Ltd...... 1718 Environ International Corp...... 1345 Dynex Technologies...... 931 Institute for In Vitro Sciences, Inc...... 1026 EUROTOX 2015...... 636 MatTek Corporation...... 620 Fraunhofer ITEM...... 928 National Library of Medicine...... 2126 Hamilton Thorne...... 1232 Three S Japan Co., Ltd...... 2021 National Jewish Health...... 518 Toxicology Excellence for Risk Assessment (TERA)...... 2231 Veritox, Inc...... 1633 Communications Cosmetic Product Safety/Toxicology Royal Society of Chemistry, Cambridge...... 2143 Charles River...... 1326

That's Nice...... 2037 CATEGORICAL LISTING CiToxLAB...... 2327 Computing Systems InSphero Inc...... 2318 Instem...... 1127 Institute for In Vitro Sciences, Inc...... 1026 Lhasa Limited...... 1635 MatTek Corporation...... 620 PDS Life Sciences...... 1634 Three S Japan Co., Ltd...... 2021 PointCross Life Sciences...... 1242 TOXI-COOP Toxicological Research Center...... 1640 ToxPlanet...... 2229 CRO—Contract Research Organization Xybion Medical Systems...... 1608 Absorption Systems ...... 309 Consulting Services Accelera S.r.l...... 2220 BioStat Consultants, Inc...... 927 Advinus Therapeutics Limited...... 2121 Cardno ChemRisk & Cardno...... 627 Algorithme Pharma...... 1141 Certara...... 1945 Alliance Pharma...... 1207 Chilworth Technology Ltd...... 1734 Aptuit LLC...... 719 Covance Inc...... 1601 BASi (Bioanalytical Systems, Inc)...... 1200 ® CTEH ...... 1136 BioTox Sciences...... 1709 ECGVET, LLC...... 1100 Calvert Laboratories, Inc...... 918 Environ International Corp...... 1345 CARE Research LLC/Colorado Histo-Prep...... 721 EPL, Inc...... 1619 Cayman Chemical...... 1001 Exponent, Inc...... 1306 CellSystems GmbH...... 1845 Hurley Consulting Associates, Ltd...... 2328 Center for Drug Safety Evaluation and Research...... 2134 Integrated Laboratory Systems, Inc. (ILS)...... 708 ChanTest Corp...... 901 Integrated Nonclinical Development Solutions, Inc...... 1343 Charles River...... 1326 MultiCASE Inc...... 1133 Clever Sys Inc...... 1138 NSF International/Health Sciences...... 1108 Comparative Biosciences (CBI)...... 737 PointCross Life Sciences...... 1242 CorDynamics...... 1206 Simulations Plus, Inc...... 2312 Covance Inc...... 1601 Strategic Applications, Inc. (SAI)...... 1216 Cyprotex...... 1733

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ChanTest Corp...... 901 Quidel...... 516 Charles River...... 1326 Quintiles...... 710 CorDynamics...... 1206 ReachBio...... 2326 Covance Inc...... 1601 Reveal Biosciences...... 519 CXR Biosciences Limited...... 1715 RTC, Research Toxicology Centre S.p.A...... 718 Detroit R & D, Inc...... 821 SCIREQ, Inc. (Scientific Respiratory Equipment)...... 2020 DiscoveRx...... 2316 Sequani Limited...... 1527 Eurofins Pharma Discovery Services...... 1319 Sinclair Research Center LLC...... 726 Epithelix...... 1244 Smithers...... 709 Experimur...... 1915 SNBL USA, Ltd...... 1215 FlowMetric...... 828 SoBran Inc...... 1029 CATEGORICAL LISTING CATEGORICAL Gentronix, Limited...... 1130 Southern Research...... 1301 HTG Molecular Diagnostics...... 1208 STEMCELL Technologies Inc...... 1101 Huntingdon Life Sciences/Harlan Laboratories...... 1515 The Jackson Laboratory...... 1107 ICDD-sas...... 731 TOXI-COOP Toxicological Research Center...... 1640 IDEXX Laboratories, Inc...... 1112 TPL Pathology Labs R&D...... 1038, 1039 IIT Research Institute (IITRI)...... 1719 Trevigen Inc...... 1810 ImQuest BioSciences...... 612 Triangle Research Labs, LLC...... 1736 In Vitro ADMET Laboratories (IVAL)...... 1420 TSE Systems, Inc...... 1927 Integrated Laboratory Systems, Inc. (ILS)...... 708 Vimta Labs Limited...... 1939 International Institute for the Advancement of Medicine..... 1820 Vivo Bio Tech Limited...... 935 Ionic Transport Assays, Inc...... 909 Vivotecnia...... 835 Jai Research Foundation (JRF - America)...... 919 Wake Forest Innovations...... 941 KCAS Bioanalytical Services...... 727 WuXi AppTec...... 1833 Korea Institute of Toxicology (KIT)...... 1117 XenoTech, LLC...... 818 Luxcel Biosciences, Ltd...... 2227 Primate Supplies/Testing Marken...... 2016 Accelera S.r.l...... 2220 MB Research Laboratories...... 1145 Bioculture (Mauritius) Ltd...... 1028 Medicilon Preclinical Research (Shanghai) LLC...... 1121 ClearH2O, Inc...... 1043 Medicyte GmbH...... 1037 Kunming Biomed International (KBI)...... 1644 Meso Scale Discovery...... 643 Noveprim Group Ltd...... 943 Microchip ID...... 1839 Primate Products, Inc...... 745 MicroMatrices Associates Ltd...... 2017 Suburban Surgical Company...... 1600 Mouse Specifics Inc...... 619 VRL Laboratories...... 2219 MPI Research...... 1801 Worldwide Primates, Inc...... 1205 NAMSA...... 916 XpressBio...... 2336 National Jewish Health...... 518 NeuroScience Associates (NSA)...... 1444 Product Development Nucro-Technics Incorporated...... 1305 Medline Industries, Inc...... 929 OtoScience Labs...... 729 Mouse Specifics Inc...... 619 Pacific BioLabs...... 820 RegCheck...... 2330 PhenoVista Biosciences...... 2120 ToxServices LLC...... 1911 PhoenixBio Co., Ltd...... 311 Product Registration Phylonix Pharmaceuticals Inc...... 1800 Porsolt...... 915 Dermal Technology Laboratory Ltd...... 1637 Pre-Clinical Research Services, Inc. (PCRS)...... 1240 Publishers PreLabs...... 1707 ACGIH®...... 610 PWG Genetics...... 1102 CRC Press—Taylor & Francis Group LLC...... 1626

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Elsevier...... 1406 RegCheck...... 2330 ExPub (Expert Publishing)...... 1909 Ricerca Biosciences LLC...... 738 Mary Ann Liebert, Inc...... 1040 RightAnswer.com...... 1011 Nature Publishing Group...... 2218 Shanghai InnoStar Biotech Co., Ltd (InnoStar)...... 1806 Oxford University Press...... 739 Smithers...... 709 Royal Society of Chemistry, Cambridge...... 2143 Three S Japan Co., Ltd...... 2021 Science/AAAS...... 1015 Tianjin Institute of Pharmaceutical Research...... 826 Springer...... 715 Toxicology Regulatory Services (TRS)...... 1113 ToxPlanet...... 2229 TOXI-COOP Toxicological Research Center...... 1640 Pulmonary Equipment/Research ToxServices LLC...... 1911 WestChina-Frontier PharmaTech Co., Ltd...... 1135 DMT-USA Inc...... 521 WIL Research...... 1019 Epithelix...... 1244 KAER Biotherapeutics...... 1841 Reproductive Toxicology SCIREQ, Inc. (Scientific Respiratory Equipment)...... 2020 Accelera S.r.l...... 2220 Pumps Arbor Assays...... 2145 ArunA Biomedical, Inc...... 2237 Instech Laboratories...... 1535 BASF SE...... 2008 Lomir Biomedical, Inc...... 1819 BASi (Bioanalytical Systems, Inc...... 1200 Strategic Applications, Inc. (SAI)...... 1216 BBD BIOPHENIX S.L. - BIOBIDE...... 313 Vitrocell Systems GmbH...... 1442 CARE Research LLC/Colorado Histo-Prep...... 721 CATEGORICAL LISTING World Precision Instruments...... 1114 Charles River...... 1326 QSAR (Quantitative Structure Activity Environmental Health Perspectives (EHP)...... 2129, 2127 Relationship) Modeling/Analysis InSphero Inc...... 2318 Leadscope, Inc...... 716 Jai Research Foundation (JRF - America)...... 919 Lhasa Limited...... 1635 Kallistem...... 2332 Molecular Networks GmbH...... 1838 Michelson Prize and Grants in Reproductive Biology...... 2240 MultiCASE Inc...... 1133 MPI Research...... 1801 National Institute of Technology and Evaluation...... 2242 Product Safety Labs...... 1701 Simulations Plus, Inc...... 2312 Sequani Limited...... 1527 Quality Assurance Shanghai InnoStar Biotech Co., Ltd (InnoStar)...... 1806 Smithers...... 709 BioStat Consultants, Inc...... 927 SNBL USA, Ltd...... 1215 Society of Quality Assurance (SQA)...... 1940 TNO Triskelion...... 1921 Toxicology Regulatory Services (TRS)...... 1113 TOXI-COOP Toxicological Research Center...... 1640 Regulatory Services/Toxicology Veritox, Inc...... 1633 Aptuit LLC...... 719 Research BioTox Sciences...... 1709 ACEA Biosciences, Inc...... 906 Calvert Laboratories, Inc...... 918 Critical Path Institute...... 743 Certara...... 1945 DiaPharma Group, Inc...... 1938 Charles River...... 1326 EMD Millipore Corporation...... 408 Critical Path Institute...... 743 Exemplar Genetics...... 1013 Douglas Connect GmbH...... 617 Mary Ann Liebert, Inc...... 1040 EPISKIN...... 633 Michelson Prize and Grants in Reproductive Biology...... 2240 Gentronix, Limited...... 1130 Pfizer Worldwide Research and Development...... 1321 Hurley Consulting Associates, Ltd...... 2328 Quidel...... 516 National Institute of Technology and Evaluation...... 2242 Royal Society of Chemistry, Cambridge...... 2143 Nat'l Center for Toxicological Research...... 614 SOLVO Biotechnology...... 1732

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