SUPPLEMENTARY DATA

Low-Dose Azathioprine With Allopurinol For Inflammatory Bowel Disease: DNA-Incorporated Deoxythioguanine and Transcriptome Analysis as Biological Indicators Sally A. Coulthard1*, Phil Berry2, Sarah McGarrity2, Simon McLaughlin3, Azhar Ansari4 and Christopher P. F. Redfern2

1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne; 2Northern Institute of Cancer Research, Newcastle University, Newcastle upon Tyne; 3Department of Gastroenterology, Royal Bournemouth Hospital, Bournemouth, Dorset; Faculty of health and social sciences, Bournemouth University, Bournemouth, Dorset 4Gastroenterology Dept., East Surrey Hospital, Redhill, East Surrey

Corresponding author *Dr Chris Redfern Northern Institute for Cancer Research, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH Telephone: +44 191 208 4416 Email: [email protected]

LIST OF SUPPLEMENTARY DATA Supplementary Figure 1: Linear model of DNA-incorporated dTG with time. Supplementary Table 1- Samples by site Supplementary Table 2 Genes significantly repressed > 1.5 fold in response to LDAA treatment Supplementary Table 3 Genes significantly over-expressed > 1.5 fold in response to LDAA treatment Supplementary Table 4 Gene Ontologies with significant enrichment for genes repressed > 1.5 fold in response to LDAA treatment BH FDR < 0.001 Supplementary Table 5 Gene Ontologies with significant enrichment for genes over-expressed > 1.5 fold in response to LDAA treatment BH FDR < 0.001 Supplementary Table 6 Genes significantly repressed > 1.5 fold in response to AZA treatment Supplementary Table 7 Genes significantly over-expressed > 1.5 fold in response to AZA treatment Supplementary Table 8 Gene Ontologies with significant enrichment for genes repressed > 1.5 fold in response to AZA treatment BH FDR < 0.05 Supplementary Table 9 Gene ontologies with significant enrichment for genes over-expressed in response to AZA for a sub-sample of three of the five AZA-treated patients Supplementary Table 10 Genes significantly repressed or over-expressed_> 1.5 fold in both LDAA and AZA-treated patients. Supplementary Table 11 Gene ontology terms associated with genes common to LDAA and AZA treatments.

Supplementary Figure 1

Linear model of dTG versus time category (approximately equal intervals of around 84 days or 12 weeks). A Box-Cox transformation (dTG values raised to power of 0.22) was applied to normalise dTG data. Red symbols are ESH data, with solid fill representing LDAA patients and open symbols are AZA-treated patients. Black (open) symbols are AZA-treated patients from other sites. Red lines are a linear model (additive for time and drug effects) fitted to the ESH data for LDAA- (solid lines) and

AZA-treated patients (dashed line); in this model the drug effect was significant (ANOVA, F1,55 = 7.8, P = 0.007 ). The black line is the same model fitted to all data (ie ESH data plus data from other sites for AZA-treated patients) as the drug effect was marginal (ANOVA, F1,122 = 3.4, P = 0.066 ). For both models, the effect of time category was significant (ANOVA, P ≤ 0.011). Similar results were obtained using time on therapy for each patient as a continuous predictor.

Number of patients in each time period by drug group.

All sites ESH only Days AZA LDAA AZA LDAA < 84 14 2 2 2 84-167 13 9 5 9 168-252 3 2 1 2 > 252 67 35 19 35 total 97 48 27 48

Supplementary Table 1- Samples by site: patients on full-dose azathioprine alone (AZA) or receiving low-dose azathioprine with allopurinol (LDAA) and with measurements of DNA-incorporated thiopurines in nucleated blood cells (NBC) Number of patients Site code AZA LDAA* CHS 6 0 DCH 2 0 ESH 27 48 NF 9 0 NTH 31 0 RBCH 12 0 STH 5 0 STT 5 0

*LDAA samples from sites other than ESH were excluded from analyses as these were from patients transferred from AZA rather than thiopurine-naïve patients as at ESH. One patient in the LDAA group at ESH was treated with the xanthine oxidase inhibitor Febuxostat instead of allopurinol.

Table S2: LDAA, genes repressed on treatment compared to pre-treatment sample.

Gene Symbol Entrez ID logFC logCPM LR PValue AANAT 15 -1.191504596 1.324612827 28.54951625 9.13E-08 ABHD12B 145447 -0.986452883 4.531484448 18.78955774 1.46E-05 ACO1 48 -0.783656985 5.053360859 20.78661167 5.13E-06 ACSL1 2180 -0.584765836 10.23477937 3.942845788 0.047071085 ACVR1B 91 -0.47842508 4.571553125 4.379700651 0.036369384 ADAM19 8728 -0.404583862 7.469457161 5.018490248 0.025078026 ADAM9 8754 -0.662526487 4.794411938 10.25916162 0.001360075 ADAMTSL4 54507 -0.436392631 7.478503265 6.063773844 0.013798252 ADAR 103 -0.422429673 9.370059669 4.31356443 0.03780966 ADCY3 109 -0.606639585 3.039347632 5.120584247 0.023643655 ADCY4 196883 -0.430251513 3.460026976 4.577854984 0.032387734 ADGRG2 10149 -0.607721356 1.810953283 5.494836664 0.019072709 ADGRG3 222487 -0.623722929 7.616781091 7.383446588 0.00658269 ADORA2A-AS1 646023 -0.628243252 2.091308555 10.24197822 0.001372803 AGBL5 60509 -0.623074106 4.023774624 9.079298561 0.002585192 AIM2 9447 -0.920724303 4.755777695 13.56699 0.000230198 AIMP2 7965 -0.502652954 1.490324981 5.500503006 0.019011004 AIRN 100271873 -0.473067169 3.765751623 6.472855782 0.010953438 ALKBH4 54784 -0.701325757 3.128429544 12.78418703 0.000349562 ALOX12 239 -0.481116481 4.175854528 8.143950049 0.004320506 ALOX5AP 241 -0.431179132 6.818494065 4.352406918 0.036956681 ANKDD1A 348094 -0.568099138 3.528232188 9.893524729 0.001658614 ANKRD18A 253650 -0.857095233 2.193215273 4.554505547 0.032832243 ANKRD22 118932 -1.302621522 2.908321407 14.6336721 0.000130561 ANKRD33B 651746 -0.677244001 4.488250653 8.171228444 0.004256007 ANKRD55 79722 -0.558854337 2.287387423 5.154498274 0.023186233 ANKS1B 56899 -1.788773459 2.052243775 65.64147302 5.41E-16 ANXA3 306 -0.899354839 6.677726157 4.700177436 0.030159504 AP4B1-AS1 100287722 -0.723104081 2.234951007 8.204900218 0.004177741 AP5B1 91056 -0.512562208 7.553037305 5.613662657 0.017820976 APOBEC3A 200315 -0.40269303 5.358019084 5.489413669 0.019131958 APOBEC3B 9582 -0.820162744 4.55877326 16.18031254 5.76E-05 APOL6 80830 -0.456430485 7.795859284 6.288499894 0.012152386 APOM 55937 -0.449254091 1.934277656 3.921347361 0.047676655 APTR 100505854 -0.517840352 3.086688847 5.932742172 0.014862097 ARGFXP2 503640 -0.714192965 2.765115491 11.6138282 0.000654633 ARHGAP24 83478 -0.477043503 4.204166096 4.54104686 0.033091349 ARHGAP26-AS1 100874239 -0.662540571 3.406569233 10.81107451 0.001008947 ARHGEF26 26084 -0.674347617 1.86755273 6.727906848 0.009491592 ARRDC5 645432 -0.467424329 2.766723783 4.332910116 0.037382281 ASAP1-IT2 100507117 -0.666691674 2.653748914 7.771574877 0.005307476 ASB14 142686 -0.67499297 2.28964838 6.062183961 0.013810679 ASB9P1 728619 -0.596545537 1.799497598 6.724579666 0.009509314 ASGR2 433 -0.689107869 3.002909194 5.781688426 0.016193978 ASPH 444 -0.551813978 6.051991591 3.845395817 0.049882746 ATAT1 79969 -0.552295203 1.775410353 6.615212249 0.010111129 ATP11B 23200 -0.433723305 7.867978251 4.088934181 0.043164853 ATP1A1-AS1 84852 -0.582602724 2.477017817 7.816144317 0.005178155 ATP8B1 5205 -0.447677953 4.295545412 5.339927615 0.020842339 ATP8B4 79895 -0.847306735 5.958904608 4.746824027 0.029352421 B4GALT5 9334 -0.569267302 7.380725393 6.029819772 0.014066169 BAIAP2L1 55971 -0.987990399 2.892133757 23.42684762 1.30E-06 BATF2 116071 -1.494752715 2.544983925 26.18651703 3.10E-07 BCL6 604 -0.615072682 8.833857711 6.416237575 0.011308149 BEAN1 146227 -0.732015198 2.013132929 9.620553006 0.001924118 BEND7 222389 -0.600543732 2.345892933 4.607443301 0.031833461 BMP8A 353500 -0.499064505 1.999112403 5.955288265 0.014673203 BMX 660 -0.784964522 3.693910467 6.08654257 0.013621538 BORCS8 729991 -0.452609747 3.130157993 6.585247864 0.01028273 BRD7P3 23629 -0.598663576 2.707637311 7.871535867 0.005021898 BST1 683 -0.475427223 5.873362641 5.850535938 0.015572308 BYSL 705 -0.562295904 3.734967314 5.194837959 0.022654067 C10orf11 83938 -0.654729685 1.344634775 7.302788606 0.006884768 C11orf42 160298 -0.927543259 1.973936626 14.0103997 0.000181802 C11orf95 65998 -0.424674072 2.3710683 4.006855202 0.0453156 C19orf44 84167 -0.534213581 1.223540751 5.948341919 0.014731136 C1orf56 54964 -1.398041657 3.727599521 56.17083581 6.64E-14 C1QTNF7 114905 -0.575618543 2.644362376 8.763635894 0.003072958 C1RL 51279 -0.509435505 6.454531116 6.35357757 0.011714483 C1RL-AS1 283314 -0.555853253 5.193299513 8.633421739 0.003300511 C3AR1 719 -0.810180226 4.68445987 10.43001619 0.001239837 C4orf19 55286 -0.492535654 1.445163008 5.178870191 0.022863186 C5orf45 51149 -0.82724434 2.878315477 18.86241161 1.40E-05 C5orf56 441108 -0.862877091 4.873769155 22.19073138 2.47E-06 C5orf58 133874 -0.530099852 4.206036802 6.629077111 0.010032723 C5orf66 100996485 -0.948506242 3.53592578 20.60069841 5.66E-06 C7orf49 78996 -0.757919495 5.509912325 14.42424983 0.000145911 C9orf139 401563 -0.550191759 3.959176642 7.708631501 0.00549574 C9orf66 157983 -0.496741255 3.373525672 7.298628557 0.006900726 C9orf84 158401 -0.978079393 7.22180488 12.32599657 0.000446693 CA4 762 -0.760642162 3.633501924 6.987731825 0.008207029 CACNA1E 777 -1.24199829 4.661005458 14.1590688 0.000167985 CAMKK2 10645 -0.437277538 7.08271834 4.453334581 0.034833166 CAPN12 147968 -0.59793688 2.529527543 9.351864544 0.002227587 CAPN3 825 -0.501043269 4.502391772 4.611278117 0.031762352 CAPNS2 84290 -0.604481025 1.759750407 4.108790905 0.042660851 CARD14 79092 -0.767677995 3.079932618 10.31699472 0.001318108 CARD17 440068 -0.481123117 1.41264383 5.015238385 0.02512517 CARD6 84674 -0.541309494 4.908407692 5.764970825 0.016348756 CBS 875 -0.810513675 2.71417436 6.755924784 0.009343691 CC2D2A 57545 -0.793144259 6.097924546 21.22221616 4.09E-06 CCDC17 149483 -0.465235772 3.31656568 5.886640789 0.015256175 CCDC36 339834 -0.477991136 2.087337431 4.895263193 0.026930468 CCDC73 493860 -0.890494635 1.747163756 15.57344931 7.94E-05 CD163 9332 -0.717452376 5.788826162 5.982041264 0.014452266 CD274 29126 -0.904738369 4.983801709 16.53926601 4.77E-05 CDH26 60437 -0.463342113 2.098834261 4.000697454 0.04548144 CDK14 5218 -0.442982123 5.311170996 6.305161823 0.012038692 CEACAM1 634 -0.880936572 5.059442885 11.84146067 0.000579264 CEACAM6 4680 -1.389387705 3.939011166 4.749400934 0.029308496 CEBPZOS 100505876 -0.44557969 3.647677901 4.597438299 0.032019766 CECR6 27439 -0.580621873 3.967181015 5.821452445 0.015831866 CENPO 79172 -0.500174027 1.914288886 4.694959785 0.030251207 CEP295NL 100653515 -0.570945662 3.838852846 8.293167482 0.003979452 CERKL 375298 -0.606381385 3.576753647 8.128620489 0.004357189 CETP 1071 -0.752612875 2.322446522 13.9753725 0.000185221 CFAP126 257177 -0.6791657 2.035750595 10.92336051 0.000949592 CFLAR-AS1 65072 -0.873077433 5.845139758 22.6984202 1.90E-06 CHKA 1119 -0.438175854 4.218019318 5.925385457 0.014924273 CHRNB2 1141 -0.781470328 3.838958988 20.15018836 7.16E-06 CKAP4 10970 -0.624403244 5.456813013 5.211425547 0.022438929 CLEC12B 387837 -0.552949464 2.583342452 5.303919896 0.021277488 CLEC17A 388512 -0.425147433 5.092029011 6.207703764 0.012719552 CLEC4D 338339 -0.991753091 5.332475253 10.1500433 0.001442979 CLOCK 9575 -0.404220546 5.337955599 5.422830699 0.019875112 CLTCL1 8218 -0.898551497 3.57544524 4.85012257 0.027644168 CNIH4 29097 -0.535837205 5.284443457 5.88560445 0.015265157 CNOT11 55571 -0.554423121 5.817603088 10.94318095 0.000939487 CNTD1 124817 -1.057746444 2.449381783 25.75241459 3.88E-07 COL17A1 1308 -1.016954675 2.578632729 5.432822598 0.019761713 COL6A3 1293 -0.606216861 1.809014602 4.084034834 0.043290169 CORO2A 7464 -0.578094019 3.859312201 5.28189586 0.021548272 COX20 116228 -0.909130406 2.892366962 16.47301824 4.93E-05 CP 1356 -0.772423137 1.997273619 12.85467561 0.000336637 CR1 1378 -0.617890581 10.26726669 5.203533043 0.022541028 CREB3L4 148327 -0.660939604 1.237493045 9.081304026 0.002582358 CSGALNACT2 55454 -0.546148786 6.612103169 6.298586927 0.012083426 CSNK1A1L 122011 -0.648921083 5.051711712 7.502275794 0.006162108 CYBB 1536 -0.526691887 8.816940724 4.500937718 0.033876272 CYP1B1 1545 -0.404501915 5.449168081 4.431411406 0.03528332 DALRD3 55152 -0.492601884 2.795246012 6.812318239 0.009053116 DCAF13P3 100132724 -0.493697428 0.938892131 4.161716128 0.041347491 DCDC2B 149069 -0.845381428 2.306514684 17.00568673 3.73E-05 DDIAS 220042 -0.773109495 2.860793908 11.6140181 0.000654566 DDX58 23586 -0.434697399 7.070780757 5.053213209 0.024580314 DDX60 55601 -0.697881442 5.96649068 9.739911149 0.001803096 DDX60L 91351 -0.769481087 8.56207505 12.72660773 0.00036049 DHCR24 1718 -0.465455391 2.145397097 4.414863987 0.035627119 DHFR 1719 -0.511921286 3.707685321 4.110317366 0.042622364 DHRS9 10170 -0.677850677 4.895019186 8.625679776 0.003314567 DHX58 79132 -0.481671641 3.415914529 6.378497431 0.011551118 DISC1 27185 -0.539321514 3.447244617 6.222646295 0.012612646 DISC2 27184 -0.729115564 2.872924048 14.18325265 0.00016584 DLEC1 9940 -0.527419454 3.467292218 7.399653056 0.006523646 DLEU1 10301 -0.445424576 4.527003918 5.488191386 0.019145338 DNAH10 196385 -0.817791112 1.742317246 6.677370159 0.009764458 DNAH17 8632 -0.985686408 5.425291264 16.79833339 4.16E-05 DND1 373863 -0.582566687 2.5299895 8.540126579 0.003474015 DOK4 55715 -0.522979445 2.180950255 5.551356812 0.018466367 DONSON 29980 -0.470632845 3.343462002 6.714533103 0.009563032 DPYD-AS1 100873932 -1.184196643 1.981855501 28.35209363 1.01E-07 DSC2 1824 -0.549861642 6.516975057 5.721799891 0.016755546 DUSP3 1845 -0.431307258 4.80067487 5.01054669 0.02519335 DYSF 8291 -0.710537642 9.310386765 5.959186752 0.014640793 EHMT1-IT1 643210 -0.627908257 1.218685961 7.67897936 0.005586776 EIF2AK2 5610 -0.782792294 6.545290916 14.33062386 0.00015335 EIF4E3 317649 -0.401900079 7.482589455 5.133269462 0.023471475 EML6 400954 -0.464793793 2.829237605 5.210819212 0.022446756 ENTPD1 953 -0.404396276 8.247328502 3.921542056 0.047671134 ENTPD1-AS1 728558 -0.910464947 4.524971703 18.77875272 1.47E-05 ENTPD7 57089 -0.496104282 4.061904099 4.005264586 0.045358377 EPB41L5 57669 -0.648095471 3.392037659 11.71638498 0.000619522 EPHX1 2052 -0.411866948 2.769671368 4.443923834 0.035025659 EPSTI1 94240 -0.852207974 5.764254661 10.83020523 0.000998576 F5 2153 -0.726155082 7.385376041 6.150637424 0.013136475 FAM151B 167555 -0.643708588 2.656387016 4.724886943 0.029729138 FAM157A 728262 -0.454293936 8.843784327 3.89865639 0.048324741 FAM157B 100132403 -0.436365162 7.994038455 3.951554548 0.046828089 FAM160A2 84067 -0.573963498 5.436821137 7.990502941 0.004702335 FAM168A 23201 -0.485146385 5.38465931 7.985600311 0.004715086 FAM196B 100131897 -0.47575076 5.606624193 7.239657811 0.007131057 FAM198B 51313 -0.536087367 5.180454979 7.724917962 0.005446383 FAM72D 728833 -0.549307325 1.594706628 5.233665384 0.022153799 FAM98C 147965 -0.61187386 3.115553312 10.81136837 0.001008787 FAN1 22909 -0.411015347 4.166609249 6.094116673 0.013563271 FANCA 2175 -0.697483328 4.030082797 16.61394047 4.58E-05 FAR2 55711 -0.46110702 5.536976019 4.44158463 0.035073679 FAS-AS1 100302740 -0.837954742 1.865774703 10.57334042 0.001147302 FAT2 2196 -0.427042365 1.745616534 3.900653455 0.048267331 FBXL5 26234 -0.416065919 8.782163951 4.600648733 0.03195986 FBXO6 26270 -0.576485862 2.981152961 6.147263177 0.013161562 FCAR 2204 -0.831732256 6.01576383 9.218963883 0.002395211 FCGR1A 2209 -1.007272442 6.023224799 14.29272096 0.000156469 FCGR1B 2210 -0.877127563 6.406771829 12.277722 0.000458398 FCGR1CP 100132417 -1.01437876 5.860019595 18.66390604 1.56E-05 FDPSP2 619190 -0.445267576 4.085537605 6.088441835 0.013606903 FGD4 121512 -0.498353928 6.700843798 4.671560938 0.030666044 FKBP1AP1 2282 -0.534868136 2.705180923 6.832244293 0.008952671 FKBP5 2289 -0.890594716 7.536708655 3.891905591 0.048519343 FNDC9 408263 -0.597939316 3.247128009 11.20825223 0.000814344 FOLR3 2352 -0.751858173 4.521096502 4.84672407 0.02769869 GABBR1 2550 -0.560521601 4.898676467 8.156929002 0.004289695 GABRR2 2570 -0.52232541 1.392251166 4.927834314 0.026427418 GALM 130589 -0.431662767 3.284931998 5.010089357 0.025200007 GALNT14 79623 -1.04753899 3.836372484 6.271515021 0.012269419 GATS 352954 -0.426150592 3.504083746 5.544194061 0.018542093 GBA 2629 -0.513348719 5.676334007 6.444095871 0.011132168 GBAP1 2630 -0.525275209 4.349311715 8.831898073 0.002960103 GBP1 2633 -0.738482895 6.721926682 11.06545879 0.000879508 GCNT1 2650 -0.593127941 4.421411382 5.966990036 0.014576141 GCNT7 140687 -0.520283712 3.23023182 7.558348086 0.005973272 GFI1 2672 -0.681059671 3.043449445 4.459813961 0.034701277 GFOD1 54438 -0.530522639 3.863653645 4.940329985 0.026237027 GIF 2694 -0.490869865 2.495146684 4.866161573 0.027388355 GK 2710 -0.501101698 7.056145795 5.161361647 0.023094784 GK3P 2713 -0.64178029 4.808466379 6.247620583 0.012436025 GLB1L 79411 -0.488462231 1.691315678 4.636739311 0.031294408 GLI1 2735 -0.43818968 5.820606501 6.000289917 0.014303528 GNAL 2774 -0.705500173 3.808392868 14.09354593 0.00017394 GNG12-AS1 100289178 -0.443197983 1.955273219 4.256852145 0.039092297 GPI 2821 -0.483562776 5.786218055 4.030815307 0.044676345 GPR141 353345 -0.911720465 4.400577069 8.201597739 0.004185352 GPR160 26996 -0.520419452 4.59369842 3.964352699 0.046473387 GPR52 9293 -0.440220395 2.469285726 5.17101614 0.022966778 GPX2 2877 -0.46226197 2.642825386 4.09846419 0.042922186 GRAMD1B 57476 -0.574683961 2.919209504 10.0482468 0.00152493 GRB10 2887 -0.830680057 4.198565823 3.925955503 0.047546164 GRIK1 2897 -0.515563984 2.168545638 5.571837798 0.018251595 GRIP1 23426 -0.618727897 3.08020762 9.079476609 0.00258494 GRIP2 80852 -0.94725632 3.169884618 25.53533339 4.34E-07 GTPBP1 9567 -0.420469632 6.501853371 5.006705344 0.025249316 GUCY2C 2984 -0.904535495 3.100069688 15.32603769 9.05E-05 GYG1 2992 -0.832631244 5.928265286 4.758551688 0.029153069 HAS3 3038 -0.484707218 2.303230893 6.034294799 0.014030555 HEATR6 63897 -0.438190799 3.422585003 5.935341118 0.014840196 HERC5 51191 -0.903654856 5.091759452 8.293053428 0.003979702 HGF 3082 -0.594606518 3.112958815 7.103494332 0.007693382 HIST1H1B 3009 -0.90199744 4.099508165 3.872949583 0.049070213 HK3 3101 -0.752427021 7.73966107 7.54451774 0.006019293 HLA-F-AS1 285830 -0.473634653 3.438176342 5.776912519 0.016238041 HORMAD1 84072 -0.655194244 3.254619373 11.16026692 0.000835679 HOXA2 3199 -0.462772404 1.366709717 4.563641664 0.032657562 HSPA1L 3305 -0.750944857 2.904337309 11.62357159 0.000651212 HTATSF1P2 401233 -0.544085039 5.143102464 6.668510106 0.009813119 HTR2B 3357 -0.505916712 1.675452459 4.027539166 0.044763189 HYAL1 3373 -0.684648128 2.279292226 8.755021225 0.003087508 IAH1 285148 -0.409237027 3.804486939 4.65458129 0.030970785 IFI16 3428 -0.670209712 7.930886739 9.589600066 0.001956826 IFI35 3430 -0.571941765 3.919540076 9.170758209 0.002459127 IFI44 10561 -1.176903545 5.348559856 12.77075041 0.000352082 IFI44L 10964 -1.392560559 5.611817929 14.60737781 0.000132395 IFI6 2537 -0.742042802 4.641919662 4.343304992 0.037154734 IFIT3 3437 -0.711068715 7.102086332 4.601778052 0.031938815 IFIT5 24138 -0.45804149 5.487449253 4.526170978 0.033380225 IFITM3 10410 -0.859148666 6.696057222 13.59945928 0.000226251 IFNK 56832 -0.526958974 2.944725409 4.569449871 0.032547016 IL10RB-AS1 100288432 -0.516320172 3.698780774 8.122715386 0.004371404 IL18R1 8809 -1.134279697 5.814519149 7.12658687 0.007594917 IL18RAP 8807 -0.991363355 6.225387457 5.162729288 0.023076606 IL24 11009 -0.449520714 2.39359824 4.373832806 0.036494817 IL27 246778 -0.552398693 1.853305526 6.842393199 0.00890195 IL4R 3566 -0.64559351 7.785708562 4.775645274 0.028865027 IRAK1BP1 134728 -0.817341614 1.693979114 14.87459079 0.0001149 IRAK3 11213 -0.797752077 7.974865741 6.410790258 0.011342892 ITGAM 3684 -0.642631885 8.535709976 6.415860184 0.011310553 ITGB4 3691 -0.704666259 2.544952624 4.970215238 0.025787438 JAK3 3718 -0.443702641 8.183572429 3.927749413 0.047495467 JDP2 122953 -0.463298989 4.30298472 4.915730836 0.026613202 JMJD6 23210 -0.437741539 4.611761387 4.574714988 0.032447143 JMJD8 339123 -0.411721037 2.395823103 3.867574279 0.049227621 KATNAL2 83473 -0.439396504 1.730086437 4.550466028 0.032909788 KCNAB1 7881 -0.498524866 2.156242961 4.456179716 0.034775188 KCNH3 23416 -0.609506782 2.5350169 5.716068925 0.016810327 KCNH7 90134 -1.012020989 5.82473193 19.91510727 8.10E-06 KCNJ15 3772 -0.659219083 8.167967733 7.665952105 0.005627256 KCNQ1OT1 10984 -0.486369107 8.141470361 6.316155565 0.011964275 KCNRG 283518 -0.658941114 3.970934919 11.09242467 0.000866811 KCNS1 3787 -0.505966808 3.168597824 7.096082536 0.007725262 KDELR3 11015 -0.428478853 2.897387975 5.231132372 0.022186084 KIAA0825 285600 -0.50199449 5.280920836 5.610564133 0.017852515 KIAA1958 158405 -0.829954368 1.719166716 12.02483425 0.000524964 KIF1B 23095 -0.808382114 7.342624516 10.27255298 0.001350238 KLHL2 11275 -0.557583148 6.456619169 4.913219357 0.026651922 KLHL29 114818 -0.598264995 2.220894829 7.047850441 0.007936043 KREMEN1 83999 -0.782321282 6.767655755 5.678359235 0.017175422 KRR1 11103 -0.411210405 4.934467225 4.002844412 0.045423546 LACTB 114294 -0.468851907 4.428190919 5.829614576 0.015758576 LAIR1 3903 -0.428879748 5.122402037 3.884394844 0.048736823 LAMB1 3912 -0.645654776 2.426956029 7.285607625 0.006950922 LAMC1 3915 -0.553939539 2.69567967 4.055444884 0.044029116 LDHAL6A 160287 -0.567317451 1.648369502 6.688424061 0.009704095 LHFPL2 10184 -0.402407786 5.199380829 5.561414034 0.018360578 LHX4 89884 -0.567722493 1.539394777 4.146533095 0.04171986 LILRA3 11026 -0.523928306 4.091010901 5.533450082 0.018656283 LILRA5 353514 -0.478139818 6.923954272 4.483502779 0.034223511 LILRA6 79168 -0.640792934 6.34740804 8.296823666 0.003971448 LILRB5 10990 -0.418340069 4.294469532 4.249199288 0.039268841 LIMK1 3984 -0.42882013 4.596726489 4.478693089 0.034319955 LIMK2 3985 -0.540069653 8.291204343 6.943914981 0.008410484 LIN7A 8825 -0.467834099 4.733562813 4.974837582 0.025718618 LINC00174 285908 -0.568868798 2.25626664 4.644713993 0.031149327 LINC00266-1 140849 -0.460440694 3.887838113 5.978934114 0.014477749 LINC00282 283521 -0.558321394 5.120382574 8.115536906 0.004388747 LINC00854 100874261 -0.668251982 2.466581067 10.34539272 0.001297982 LINC00937 389634 -0.805815815 4.755590774 9.869669157 0.001680257 LINC01270 284751 -0.470387353 3.703042741 3.848386613 0.049793867 LINC01347 731275 -0.478730982 6.784520498 6.1112004 0.013432787 LINC01531 100128682 -0.86058247 2.567022613 11.72853521 0.00061549 LINC01547 84536 -0.444164282 2.600925881 4.408062094 0.035769454 LIPE-AS1 100996307 -0.602309477 2.344707992 6.876800928 0.008732172 LMNB1 4001 -0.619429778 6.889727029 6.934683203 0.008454004 LOC100128770 100128770 -0.675620238 3.216601323 12.77894881 0.000350542 LOC100129083 100129083 -1.417689454 2.621557224 25.82325907 3.74E-07 LOC100129617 100129617 -0.446274751 2.566750752 4.531278411 0.033280747 LOC100129931 100129931 -1.558284118 3.710451158 59.63406238 1.14E-14 LOC100130950 100130950 -0.817352612 2.026516109 15.7040044 7.41E-05 LOC100131496 100131496 -0.571209878 1.56412524 6.456484797 0.011054813 LOC100133331 100133331 -0.530894612 9.33402524 4.720568043 0.029803896 LOC100288069 100288069 -0.522496118 7.469161118 6.752557212 0.009361342 LOC100294362 100294362 -1.178876154 4.895296001 47.08107878 6.81E-12 LOC100379224 100379224 -1.04442385 2.380309989 24.3887504 7.87E-07 LOC100499194 100499194 -0.47847692 2.666137244 6.171736067 0.012980717 LOC100505658 100505658 -0.559102205 3.904765861 7.08221161 0.007785287 LOC100505716 100505716 -0.444958344 2.402220971 4.196348677 0.040511117 LOC100506023 100506023 -0.578445369 2.619617068 7.713727225 0.005480248 LOC100506321 100506321 -0.584068123 3.23071093 9.940599436 0.001616729 LOC100506497 100506497 -0.505824524 1.43929611 5.624111547 0.017715043 LOC100652768 100652768 -0.451297601 2.389849252 5.044765019 0.024700457 LOC148696 148696 -0.403301463 5.043554378 4.869357604 0.027337675 LOC285819 285819 -0.518192237 1.55421801 5.228864427 0.022215032 LOC339874 339874 -0.558289532 1.68983618 4.488207072 0.034129454 LOC399715 399715 -0.819252956 4.681648404 7.962385587 0.004775943 LOC441081 441081 -0.722619596 7.846032742 9.799025107 0.001746044 LOC553103 553103 -0.67283866 2.670903918 7.46096771 0.00630511 LOC641367 641367 -0.622228549 1.936605213 6.608157696 0.010151263 LOC645513 645513 -0.415930078 3.190747007 4.105804895 0.042736245 LOC728175 728175 -0.60489622 1.797835468 7.624985042 0.005756515 LOC729737 729737 -0.565970871 9.194368703 4.358125201 0.03683282 LONRF3 79836 -0.573206569 2.47771735 5.459451118 0.01946276 LOXL3 84695 -0.650736651 3.047450042 8.816515707 0.002985161 LRRN1 57633 -0.907604979 2.799601242 8.998004177 0.002702746 LRTOMT 220074 -0.628233692 4.007244728 12.16666937 0.000486511 LYSMD1 388695 -0.444869942 3.814856194 6.075621082 0.01370601 LYSMD4 145748 -0.615354881 2.793315102 7.178508713 0.007378201 M1AP 130951 -0.763981551 1.541267624 13.12369865 0.000291584 MAGI3 260425 -0.758569874 2.883483526 9.629584361 0.001914679 MAP2K6 5608 -0.717589088 4.265944204 6.298485031 0.01208412 MAPK12 6300 -0.511313683 1.820405335 6.183876729 0.012891951 MAPK14 1432 -0.712050058 8.433211053 7.212540234 0.007239596 MBNL1-AS1 401093 -0.403095787 5.349691777 4.706998441 0.030040057 MCAM 4162 -0.471376204 1.249009589 4.507143008 0.033753575 MCEMP1 199675 -1.266903538 4.831539679 7.318133389 0.006826228 MCM3AP-AS1 114044 -0.606263825 2.465336628 7.069916667 0.00783889 MCTP1 79772 -0.48790026 6.218033792 6.853517024 0.008846695 MCTP2 55784 -0.628868352 8.472250512 5.966513482 0.014580081 MEGF11 84465 -0.425270553 3.624468432 5.011131942 0.025184835 MFSD13A 79847 -0.446242253 3.324920407 4.066295732 0.04374711 MFSD14B 84641 -0.467442837 6.011748093 5.180388698 0.022843213 MGAM 8972 -0.506780203 9.784847499 4.007361177 0.045302002 MGAM2 93432 -0.807751314 3.797588686 14.66724016 0.000128256 MIR21 406991 -0.527941884 1.857636338 4.991128551 0.025477587 MIR223 407008 -0.580985177 5.141990634 4.269393212 0.038804785 MIR3945HG 731424 -0.54922029 3.276384523 4.442426937 0.03505638 MIR4257 100422997 -0.600953478 2.603947789 7.281208852 0.006967963 MIR4513 100616183 -0.681559272 1.663744104 8.162664806 0.00427615 MIR4802 100616274 -0.496727684 1.708017993 4.25974496 0.03902578 MKI67 4288 -0.52813224 5.051791875 4.28314028 0.03849217 MKNK1-AS1 100507423 -0.84950438 3.173633543 9.888511327 0.001663139 MMP24 10893 -0.671985631 3.556231353 12.41734882 0.000425364 MROH6 642475 -0.794687334 1.987311757 9.635972429 0.001908032 MRPL16 54948 -0.440200769 4.124575877 6.777061923 0.009233676 MRS2P2 729633 -0.549266072 2.424131829 4.764690149 0.029049288 MRVI1-AS1 100129827 -0.421497922 2.901590757 5.033640494 0.024859591 MS4A4A 51338 -0.975260072 1.643770024 10.91791835 0.000952386 MSL3 10943 -0.589936702 6.704630894 6.900513872 0.008617098 MSMP 692094 -0.518948815 2.125021614 5.572498806 0.018244706 MTF1 4520 -0.40057961 6.169913033 4.188054247 0.040709796 MTMR8 55613 -0.472384938 1.526835387 4.368194638 0.036615766 MTRNR2L8 100463486 -0.951117463 3.442763529 20.72057078 5.31E-06 MTVR2 246754 -0.449060022 1.279734468 3.961810538 0.046543617 MUC6 4588 -0.521432362 1.101950524 4.138322087 0.041922705 MX1 4599 -0.904684199 6.523921564 8.606993943 0.003348745 MYBPC3 4607 -0.441872215 4.056571469 5.144748457 0.023316788 MYH7B 57644 -0.532868419 3.333148831 5.573258942 0.018236788 MYL5 4636 -0.581544943 2.862969996 8.732582381 0.003125735 MYRIP 25924 -0.601037327 2.394075898 7.074428659 0.007819175 MZF1-AS1 100131691 -0.561947056 1.506001905 6.817226092 0.009028269 NA 100272216 -0.875879263 7.166684448 13.33476373 0.000260531 NAIP 4671 -0.594078751 9.88643713 4.278399614 0.038599676 NCR1 9437 -0.507985805 2.870560347 4.286908114 0.03840695 NIPAL4 348938 -0.654931996 2.822888831 9.827212114 0.001719488 NIPSNAP3B 55335 -0.603519667 3.145174798 5.27505871 0.021633058 NLGN3 54413 -0.417046264 3.025116745 4.661396254 0.030848096 NLRC4 58484 -0.713612153 6.16386178 5.031978916 0.024883451 NLRC5 84166 -0.451464404 8.035228539 6.211799767 0.012690155 NME8 51314 -0.679995164 3.486427277 10.80872654 0.001010228 NOCT 25819 -0.597899071 4.07766487 10.50427791 0.001190985 NQO1 1728 -0.566529385 1.361035415 6.169516291 0.012997014 NQO2 4835 -0.547377311 5.521605013 5.39539232 0.020189986 NRADDP 100129354 -0.446459842 1.254728442 4.125942156 0.042230499 NRG1 3084 -0.837691707 2.322505207 13.13912946 0.000289192 NRIP2 83714 -0.495293363 3.030379216 7.422364199 0.006441812 NTNG2 84628 -0.846356161 4.749251932 11.98078955 0.000537518 NUTM2G 441457 -0.490022281 4.009260681 6.113704114 0.013413772 OAS1 4938 -0.839398716 5.135632285 11.98375336 0.000536664 OAS2 4939 -0.496620629 5.87088121 5.655158265 0.017404104 OAS3 4940 -1.111467725 6.180356649 11.85157237 0.000576127 OASL 8638 -0.764540168 4.712388348 9.009080256 0.002686416 OGN 4969 -0.68488213 1.378285705 6.050564865 0.013901849 OMG 4974 -0.650176788 2.450990365 7.546048349 0.006014182 OPLAH 26873 -0.859884454 3.318367944 5.787574997 0.016139838 P2RX1 5023 -0.423754702 6.005435382 5.90368258 0.015109262 PABPC1L 80336 -0.427544363 4.364866164 5.328323532 0.020981558 PADI2 11240 -0.441392499 8.081851795 4.045214625 0.044296746 PADI4 23569 -0.631918965 7.04014684 7.181476564 0.007366006 PALLD 23022 -0.449154221 2.63824168 4.501925058 0.033856718 PAPLN 89932 -0.597423099 3.96000372 9.9633915 0.001596836 PARP12 64761 -0.436856074 5.242776489 6.367391652 0.011623632 PARP14 54625 -0.575695633 8.852971056 8.464216254 0.003622013 PARP9 83666 -0.680437344 7.462223305 12.20844549 0.000475737 PDE1B 5153 -0.471228564 2.944103303 5.579540181 0.018171493 PDK4 5166 -0.683577197 4.51132285 13.38683684 0.000253396 PDSS1 23590 -0.646258894 1.912613742 7.66051429 0.005644241 PDZD2 23037 -0.473097587 3.517612964 7.483519291 0.006226625 PFDN1 5201 -0.481696067 3.858175999 5.319809716 0.021084314 PFKFB2 5208 -0.973782008 5.997624129 9.458566568 0.002101652 PFKFB3 5209 -0.816967095 7.198425929 8.165027534 0.004270583 PGAP2 27315 -0.495400496 3.969841061 7.280381787 0.006971172 PGD 5226 -0.607401374 7.586861652 7.697961142 0.005528324 PGM1 5236 -0.489007014 4.228035831 4.632147406 0.031378267 PGS1 9489 -0.545847611 7.021668208 5.43589863 0.019726938 PHF21A 51317 -0.406085581 7.302491701 4.772576656 0.028916517 PHTF1 10745 -0.822060059 5.277086868 10.94021027 0.000940995 PIK3AP1 118788 -0.403727949 7.754805658 3.924720353 0.047581103 PIK3CD-AS1 644997 -0.565058421 5.211042242 11.16249726 0.000834675 PITRM1-AS1 100507034 -0.472942285 2.248492378 5.310193601 0.021201 PIWIL4 143689 -0.826523937 2.300127028 4.08388733 0.043293947 PKD2L2 27039 -0.714353444 2.169577381 8.308424467 0.003946161 PLAC9 219348 -0.615799323 1.229030764 8.133104784 0.004346425 PLB1 151056 -0.444652071 5.563655063 3.844348016 0.049913924 PLCD4 84812 -0.511028947 1.779340283 5.052215063 0.024594478 PLEKHG6 55200 -0.429951278 4.273779755 6.238788009 0.012498198 PLIN2 123 -0.436060393 4.316615887 6.009986806 0.014225134 PLIN4 729359 -0.505358356 5.120261658 4.463413105 0.034628241 PLSCR1 5359 -0.932826025 6.581199571 10.78403086 0.001023795 PLTP 5360 -1.620616121 2.0753187 57.01533719 4.32E-14 PML 5371 -0.485619985 5.298134188 6.497725241 0.01080126 PNPLA1 285848 -0.488814699 2.449645904 4.914463009 0.026632741 POU5F1P3 642559 -0.599541847 2.544786614 7.620526506 0.005770764 PP2D1 151649 -0.801791965 2.402316531 9.074604759 0.002591836 PPL 5493 -0.456149081 4.428456221 5.265913262 0.02174701 PPP4R1L 55370 -0.462781373 4.466812198 6.061124693 0.013818965 PPT2-EGFL8 100532746 -1.171232617 1.556656374 17.34986474 3.11E-05 PRDM5 11107 -0.48227936 3.133618064 4.288113704 0.038379724 PRELID1 27166 -0.511781356 4.353736735 6.932709552 0.008463337 PRG4 10216 -0.889894212 2.028139996 17.07005361 3.60E-05 PRICKLE3 4007 -0.557090955 2.042396442 7.226612001 0.007183064 PRKCD 5580 -0.457164685 6.984405201 5.863121571 0.01546135 PROX2 283571 -0.415093315 2.133623907 4.213487093 0.040103814 PRR7-AS1 340037 -0.481600692 4.300783193 8.034773577 0.004588775 PRUNE2 158471 -0.886944967 2.681406351 7.593880572 0.005856675 PSMC3IP 29893 -0.893737495 1.954498915 15.99664728 6.35E-05 PSTPIP2 9050 -0.735971107 6.264375956 8.257550698 0.004058285 PTBP2 58155 -0.446612116 4.368852785 4.792237365 0.028588269 PTCHD3P1 387647 -0.616218473 4.088662349 12.15060485 0.000490719 PTPMT1 114971 -0.55812829 1.321118346 6.452862468 0.011077373 PXK 54899 -0.484532328 5.606473102 4.83253782 0.027927493 PXN-AS1 100506649 -1.361411304 1.976934217 39.77497502 2.85E-10 PYGL 5836 -0.51907974 8.641236242 4.162850415 0.041319813 RAB15 376267 -0.414982015 3.387326811 5.667319662 0.017283845 RABGEF1 27342 -0.411136006 4.724407198 4.517188066 0.033555939 RAD9A 5883 -0.429569821 3.254415816 5.261491907 0.021802322 RALGAPA2 57186 -0.543809798 7.647387001 6.646228752 0.009936592 RBM5-AS1 100775107 -0.675275189 4.309501097 15.10722348 0.000101574 RBP5 83758 -0.78342504 2.60499297 12.60770679 0.00038416 RBPMS 11030 -0.423285092 2.261828581 4.075479173 0.043509924 REC8 9985 -0.722880923 4.151371162 13.75577014 0.00020818 RGL4 266747 -0.71501312 5.249942275 8.040986919 0.004573062 RHBDF2 79651 -0.491056162 5.388501473 6.304489657 0.012043258 RNASEH2C 84153 -0.441410388 3.446805013 6.269992958 0.012279963 RNF175 285533 -0.613280484 4.70544333 6.815859381 0.009035181 RNF213 57674 -0.532829602 10.4158545 5.461894796 0.01943556 RNF215 200312 -0.537602998 1.046809829 5.587955844 0.018084389 RNF39 80352 -0.708388018 1.618672435 11.03517667 0.000893992 ROPN1L 83853 -0.667014866 3.311066569 9.013239042 0.00268031 RRM2 6241 -0.992562189 2.553851993 4.869175047 0.027340567 RSAD2 91543 -0.820149559 5.817521032 5.413072521 0.019986508 SAMD9L 219285 -0.717857398 7.772942577 12.17307373 0.000484843 SAP30L-AS1 386627 -0.479335223 3.363866099 5.290110193 0.021446863 SCRG1 11341 -0.846090799 1.634792959 8.997604755 0.002703337 SCUBE3 222663 -0.402036674 2.959042833 4.158906406 0.041416136 SDCBP2-AS1 100507495 -0.558005361 4.402950668 10.10733757 0.001476802 SDR39U1 56948 -0.564468984 2.655251047 7.757058875 0.005350301 SEMA4A 64218 -0.500189458 6.856161007 4.198760513 0.040453537 SENCR 100507392 -0.44059399 3.215274764 5.692171795 0.017040752 SERINC4 619189 -0.958886398 2.043868898 21.92513679 2.83E-06 SERPING1 710 -1.155429379 3.311399176 16.85186959 4.04E-05 SEZ6 124925 -0.497816067 2.475630437 5.293682848 0.021402911 SFXN5 94097 -0.470676497 4.33283255 5.285283707 0.021506388 SGMS2 166929 -0.622472922 3.937307222 6.737908899 0.00943852 SH3BP5-AS1 100505696 -0.591441971 4.747616047 11.59227157 0.000662265 SIGLEC1 6614 -1.311428039 3.411583568 15.20548992 9.64E-05 SIPA1L2 57568 -0.602846112 6.26255869 4.753742271 0.02923465 SLC10A1 6554 -0.429763518 3.098441409 5.164611229 0.023051617 SLC16A4 9122 -0.425998335 3.099104119 4.257881664 0.039068611 SLC1A4 6509 -0.503796554 3.366383605 4.450822015 0.034884451 SLC22A15 55356 -0.551608841 5.453328535 6.454663852 0.011066148 SLC22A4 6583 -0.418766299 5.25022128 4.857260308 0.02753002 SLC23A1 9963 -0.627809313 1.98868746 9.131032436 0.002513099 SLC24A4 123041 -0.410448433 5.712330048 5.899991768 0.015140956 SLC25A40 55972 -0.549951993 4.575926816 5.13682237 0.023423484 SLC26A6 65010 -0.666915071 1.997257008 5.489240292 0.019133856 SLC26A8 116369 -1.254243098 4.997195014 14.73512277 0.00012372 SLC2A3 6515 -0.567642858 8.82810132 6.179348737 0.012924984 SLC35A4 113829 -0.502651681 4.401055721 4.849123924 0.027660178 SLC37A3 84255 -0.633173699 5.776415287 5.960409786 0.01463064 SLC39A13 91252 -0.660135377 4.777897697 15.27444514 9.30E-05 SLC51A 200931 -0.958865637 3.207428409 13.848905 0.000198112 SLC8A1-AS1 100128590 -0.578043751 3.150514511 6.843054751 0.008898654 SLC9A1 6548 -0.429605554 4.838424094 4.509409031 0.033708885 SLC9A8 23315 -0.573680778 6.15135352 7.051462882 0.007920054 SLCO4C1 353189 -0.493564723 5.164294683 5.275365953 0.021629241 SLED1 643036 -0.796108868 4.117358847 12.18320729 0.000482217 SMA5 11042 -0.492132103 6.29777156 7.038084288 0.007979434 SMARCD3 6604 -0.538311874 4.556856888 5.889767752 0.015229109 SMTNL1 219537 -1.346216147 2.823271602 39.50643303 3.27E-10 SND1-IT1 27099 -0.588854006 4.196769513 11.1802902 0.000826708 SNORA70G 100379132 -0.691167502 2.114371029 9.004604206 0.002693003 SNORD89 692205 -0.491839919 3.356472933 7.028059267 0.008024227 SNRK-AS1 100873954 -1.535039733 3.968594716 72.20130603 1.94E-17 SNX21 90203 -0.509540138 2.03664381 4.955026987 0.026014919 SNX22 79856 -0.520149501 4.148670042 7.836053414 0.00512143 SNX32 254122 -0.536855973 2.106784242 7.223480046 0.007195607 SOCS3 9021 -0.535000984 5.50952507 4.870383474 0.027321429 SORT1 6272 -0.548632843 6.19579903 5.018142172 0.025083067 SPAG5-AS1 100506436 -0.976266342 1.524477613 20.16663955 7.10E-06 SPATA21 374955 -0.999149445 1.912528547 14.84835709 0.00011651 SPDYE3 441272 -0.728482739 3.459350034 15.87431801 6.77E-05 SPDYE8P 389517 -0.484013759 5.806123783 7.031732097 0.008007786 SPIN4 139886 -0.534272977 1.733965344 4.718495866 0.029839834 SPNS2 124976 -0.451558437 1.444571328 4.172911819 0.04107515 SRPK1 6732 -0.631560303 7.50353459 6.893634699 0.00865032 SRPK3 26576 -0.476737337 1.539681111 4.536820663 0.033173151 SRSF12 135295 -0.591428798 2.363131653 4.70159973 0.030134556 SRSF9 8683 -0.414306787 4.09331158 5.541157371 0.018574295 ST20-AS1 283687 -0.44595622 2.62794682 4.616743395 0.031661295 ST3GAL4-AS1 399972 -0.704867737 3.05190402 5.128570205 0.023535107 STAG3 10734 -0.546031111 2.950028727 5.831769715 0.015739282 STARD5 80765 -0.610192549 3.839953132 11.45083679 0.000714618 STARD7-AS1 285033 -0.54994789 2.550425516 8.101008042 0.004424065 STAT1 6772 -0.506754697 8.280601393 7.859029925 0.005056752 STAT2 6773 -0.497341099 7.336316794 8.938812425 0.002791742 SYCP3 50511 -1.17261286 2.812468309 28.11950583 1.14E-07 SYNC 81493 -1.077959509 2.497697515 19.36555946 1.08E-05 SYT2 127833 -0.505674555 4.28256386 7.935105077 0.004848481 TAC4 255061 -0.540721029 1.816467874 5.162129537 0.023084576 TAS2R40 259286 -0.655671323 2.498741354 4.622250148 0.031559811 TBC1D7 51256 -0.404945417 3.163574294 4.565058625 0.032630557 TBC1D8 11138 -0.805144848 4.819531008 7.49545647 0.006185485 TCAIM 285343 -0.699143501 5.119900188 8.152109935 0.004301109 TCN2 6948 -0.583793862 1.741139152 4.332896763 0.037382574 TDRD9 122402 -1.008754045 3.872901115 5.951670514 0.014703346 TEAD2 8463 -0.458951233 1.470111857 4.861722455 0.027458909 TENM1 10178 -0.614228217 4.811186903 11.63675689 0.000646612 THBS3 7059 -0.414605679 4.399416308 4.829771398 0.027972339 THBS4 7060 -0.450295064 2.456105579 4.690292181 0.030333489 TIMELESS 8914 -0.504315462 2.29083966 4.477883836 0.034336211 TIMM10 26519 -0.528777703 1.701647039 4.053564214 0.044078187 TLDC2 140711 -0.84794203 4.379685207 22.77513433 1.82E-06 TLR5 7100 -0.877725137 5.887064368 7.687461487 0.005560579 TMED8 283578 -0.5839679 3.721489761 5.785735474 0.016156737 TMEM106A 113277 -0.485960178 4.158682697 7.808030812 0.005201455 TMEM120B 144404 -0.446303698 3.247085512 4.4834454 0.03422466 TMEM132A 54972 -0.514027834 2.384355983 6.152516593 0.013122524 TMEM144 55314 -0.834265889 2.62977583 12.51823427 0.000403 TMEM170B 100113407 -0.467679237 6.481052144 5.78447393 0.016168336 TMEM176A 55365 -0.443490081 2.78949266 4.285252552 0.038444371 TMEM200B 399474 -0.724434139 3.694557264 12.1079027 0.000502086 TNFAIP6 7130 -0.674153373 4.70018477 8.178736633 0.004238427 TNFSF13B 10673 -0.431792952 6.333194997 5.207026436 0.022495778 TOMM40L 84134 -0.41867498 2.454115574 4.641889464 0.031200633 TONSL 4796 -0.622596404 1.230697439 5.656033216 0.017395423 TOR1B 27348 -0.488368125 4.758656916 8.403810315 0.003744354 TP53I11 9537 -0.672773197 5.132854458 5.311457247 0.021185628 TP53I3 9540 -0.768790306 2.707780339 6.804999571 0.009090298 TPST1 8460 -0.555379308 3.442199982 4.095998917 0.042984823 TPTEP1 387590 -0.432218443 3.605285177 4.827390895 0.02801099 TREML4 285852 -0.443658291 3.759076297 5.182360737 0.022817302 TRIB1 10221 -0.514872386 5.112194667 5.208624877 0.022475104 TRIM13 10206 -0.464601547 6.714297821 6.123430831 0.013340165 TRIM17 51127 -0.405473444 2.458575754 4.214981773 0.040068497 TRIM22 10346 -0.764372744 7.855692333 15.37369105 8.82E-05 TRIM25 7706 -0.47069261 8.467193709 5.820181272 0.015843312 TRPS1 7227 -0.53140909 5.637283883 6.252565335 0.012401358 TRPT1 83707 -0.850593125 2.807465828 14.27747499 0.000157741 TSPAN16 26526 -0.57117015 4.280175536 8.273737348 0.004022262 TSSK3 81629 -0.558237255 2.701705999 6.012937636 0.014201366 TTC7B 145567 -0.465950646 3.719780959 6.076922734 0.013695914 TTLL3 26140 -0.441232071 5.353879536 5.804523317 0.015985001 TTN 7273 -0.412197401 8.615865081 4.57827956 0.032379709 TTYH1 57348 -0.571472566 1.750567483 6.844668312 0.00889062 TUB 7275 -0.500715309 1.636296823 5.462341396 0.019430593 TVP23A 780776 -0.609614669 1.30906997 7.56494184 0.005951457 UHRF1 29128 -0.834085743 2.820070432 10.55276107 0.001160147 UNC5A 90249 -0.984901691 4.489651173 13.55196786 0.000232048 UPB1 51733 -0.760104739 1.445310042 8.394509119 0.003763561 UPP1 7378 -0.702576698 4.901273958 4.832653224 0.027925623 USB1 79650 -0.550632754 5.226906411 5.388780985 0.020266624 USP35 57558 -0.4383996 3.390728418 6.325394328 0.011902102 USP3-AS1 100130855 -0.938261264 3.770858297 21.50507961 3.53E-06 VAT1 10493 -0.532569158 3.701649948 4.237218328 0.039546911 VEGFA 7422 -0.435846323 3.173946746 3.893786333 0.048465044 VPS9D1 9605 -0.665181213 4.568549935 7.171889775 0.007405472 VPS9D1-AS1 100128881 -0.586911287 2.548690689 5.332149453 0.020935551 VSIG10 54621 -0.727286901 2.194480807 10.26386842 0.001356609 VSIG4 11326 -0.582176956 4.372855588 9.654404233 0.001888981 WDFY3 23001 -0.51429281 8.843470803 4.088107236 0.043185978 WDR83 84292 -0.502959598 2.548490015 6.525994279 0.01063091 WNT4 54361 -0.538682026 3.089092737 7.388189723 0.006565353 WSB1 26118 -0.584105805 7.706977243 6.576059293 0.010335947 XAF1 54739 -0.746271731 6.634450928 10.76975214 0.001031723 ZACN 353174 -1.290402209 1.959931752 32.37820884 1.27E-08 ZBP1 81030 -0.505680963 5.177579409 7.266904061 0.007023677 ZBTB11-AS1 100009676 -0.58134928 1.532471927 6.702461555 0.00962799 ZC3H12C 85463 -0.510005862 2.328759371 4.975549814 0.025708031 ZNF233 353355 -0.551610287 1.518431502 6.616166451 0.010105713 ZNF438 220929 -0.580220764 5.516615179 6.659353858 0.009863667 ZNF821 55565 -0.43709606 1.591601713 4.300401372 0.038103379 ZRANB2-AS1 100132618 -0.550654568 1.917103513 4.035561602 0.044550845 Table S3: LDAA, genes over-expressed on treatment compared to pre-treatment

Gene Symbol Entrez ID logFC logCPM LR PValue ABCB10 23456 0.431150116 5.220049392 5.08961457 0.024069541 ABCC13 150000 1.373210243 4.680090967 35.5439776 2.49E-09 ABCG2 9429 1.018860328 3.329836042 15.09581529 0.00010219 ACD 65057 0.559010972 2.480091538 7.14338837 0.007524086 ACP1 52 0.742392404 5.453388724 13.24560349 0.00027322 ACSL6 23305 0.681038334 4.514055768 12.18363465 0.000482106 ACSM3 6296 1.250568848 2.006993577 16.1471353 5.86E-05 ADAL 161823 0.476152366 2.283352643 3.965755519 0.04643468 ADAMTS6 11174 0.521869107 1.772566273 4.440513418 0.035095692 ADD2 119 0.688120667 2.189447496 7.701453477 0.005517638 ADIPOR1 51094 0.542772773 10.06524361 4.7357474 0.02954201 AEN 64782 0.759996612 3.224909696 12.47099869 0.000413319 AGAP1 116987 0.772227647 1.629310868 11.19154736 0.000821708 AGAP12P 399753 0.421080129 3.30557794 4.824436052 0.028059043 AGAP7P 653268 0.481345928 4.470093327 4.328360533 0.037482332 AHSP 51327 1.469007317 5.620895696 33.31976595 7.82E-09 AIDA 64853 0.467453551 6.415341056 5.344982796 0.020781989 AKAP12 9590 0.550415779 3.100170852 5.072618707 0.024306637 AKAP7 9465 0.632387459 5.13277174 9.464921447 0.002094384 ALDH5A1 7915 0.617958469 5.530745089 6.472634244 0.010954804 ALKBH7 84266 0.520158643 1.838879072 5.188693157 0.022734306 ALS2CR12 130540 0.492171268 6.277861379 4.399050004 0.035958956 AMPD2 271 0.482190148 6.722643712 5.282696513 0.021538366 ANGPT1 284 0.530912869 2.946923324 5.910431399 0.015051485 ANK1 286 0.601274763 7.336084755 4.778005726 0.028825485 ANKRD20A9P 284232 0.515205175 4.096224464 5.985555807 0.014423497 ANKRD36BP2 645784 0.939928735 6.30427805 11.13671331 0.000846357 APBB1 322 0.502462904 3.633876231 5.288898381 0.021461792 APLF 200558 0.530107745 4.33514269 5.979282286 0.014474891 APOPT1 84334 0.476050481 2.024458776 5.394393752 0.020201542 AQP3 360 0.44036321 3.941565152 4.58517128 0.032249748 ARHGEF12 23365 0.521095393 8.153521469 6.06601646 0.013780742 ARL4A 10124 1.045068483 6.930250627 34.71485039 3.82E-09 ARL6IP1 23204 0.601443864 7.003725726 11.79255527 0.000594681 ASCC2 84164 0.54535666 7.54236159 4.806229218 0.02835703 ASNA1 439 0.463134877 3.676993781 6.26724494 0.012299023 ATF7IP2 80063 0.627492242 4.684424114 7.479302485 0.006241225 ATP23 91419 0.64699519 2.758692871 10.38000822 0.001273871 ATP5E 514 0.692215383 5.934644517 12.44789555 0.000418463 ATP5EP2 432369 0.699978464 3.517444635 9.52160967 0.002030664 ATP5I 521 0.413943168 4.207104299 4.178655643 0.04093616 ATP5L 10632 0.487198875 5.568275268 7.595415398 0.005851691 AURKA 6790 0.801623959 3.923945244 16.93261577 3.87E-05 AVPR1A 552 0.707599304 1.99549265 11.16177835 0.000834998 BAG1 573 0.707593072 7.278296503 8.849562406 0.002931592 BARD1 580 0.455716103 4.144168662 3.844114536 0.049920874 BBOF1 80127 0.827120406 5.725902427 20.73805944 5.27E-06 BBS12 166379 0.692828117 1.690756778 6.769040074 0.009275271 BCL11B 64919 0.413571427 6.108957247 4.452193232 0.034856453 BCL2L1 598 0.638816498 9.329129314 4.775088592 0.028874361 BDH2 56898 0.602621176 1.431752646 6.652888427 0.009899522 BLVRB 645 1.185716991 6.522585423 26.55194391 2.57E-07 BMS1P5 728053 0.464515515 5.88159587 4.152466444 0.041573925 BNIP3L 665 1.020437107 11.55318165 14.84546065 0.000116689 BPGM 669 0.950037975 7.918845586 24.16935435 8.82E-07 BRIP1 83990 0.480793802 3.882587095 5.622186358 0.017734512 BSG 682 0.642102178 8.016839222 4.507859949 0.033739429 BTF3 689 0.747579403 7.502249042 15.21934872 9.57E-05 C11orf58 10944 0.440828202 6.22199364 6.458850526 0.011040104 C12orf29 91298 0.645384688 3.107035618 12.44466649 0.000419187 C12orf57 113246 0.743402965 2.19527914 11.73637892 0.000612902 C15orf54 400360 0.941405251 2.155442069 19.07426175 1.26E-05 C19orf53 28974 0.440613056 3.328567515 4.332094343 0.0374002 C19orf70 125988 0.640318859 1.963020904 7.625557681 0.005754687 C20orf196 149840 0.700758441 2.748973219 10.55368135 0.001159569 C2orf74 339804 0.453032276 1.985422596 3.956890402 0.04667986 C6orf48 50854 0.452700154 4.311893497 5.832805667 0.015730017 C7orf73 647087 0.453490628 7.282234189 4.914618323 0.026630346 C9orf40 55071 0.676358564 3.640150683 11.1906849 0.00082209 C9orf78 51759 0.528606924 8.116172039 6.113200762 0.013417593 CA1 759 1.471518371 8.105033512 31.43960245 2.06E-08 CA2 760 0.548920484 5.640855582 6.630885509 0.010022543 CACNB4 785 0.821337555 2.17578846 4.240438834 0.039471963 CAMLG 819 0.449158068 3.822631007 6.484699259 0.010880695 CARM1 10498 0.491090711 4.90873195 3.914058415 0.047883832 CCDC124 115098 0.703953561 2.608530482 5.223014267 0.022289882 CCDC15 80071 0.562783599 3.793131276 6.596083884 0.010220332 CCDC7 79741 0.511647892 3.655058478 7.047271265 0.00793861 CCDC91 55297 0.40001911 5.216577357 4.007755847 0.045291398 CCL4 6351 0.555017374 2.348473893 6.840945192 0.008909169 CCL4L1 388372 0.64340607 2.1339504 5.275051409 0.021633149 CCNB1 891 0.66778395 3.041385273 6.36013118 0.011671291 CCNG1 900 0.433229593 5.498035722 6.783363003 0.009201137 CCT2 10576 0.506467318 5.51627532 8.691850872 0.003196359 CD1C 911 0.446888032 2.282534917 4.275391789 0.038668049 CD2 914 0.426791869 5.205778703 4.167451107 0.041207748 CD28 940 0.423185983 5.441337966 3.915994764 0.047828702 CD2AP 23607 0.478304972 5.637753136 4.952829605 0.026048002 CD3D 915 0.828524968 4.7763371 11.33283495 0.000761486 CD52 1043 0.427396383 6.610089602 4.278087361 0.038606768 CD6 923 0.509368717 5.138261024 4.111517135 0.042592139 CD7 924 0.713864376 3.358640924 6.862495299 0.008802354 CD79B 974 0.400765091 3.993273946 3.911717792 0.047950562 CD83 9308 0.582260627 2.030114443 7.010148954 0.008104894 CD8A 925 0.536587555 4.421635718 7.142133009 0.007529355 CD8B 926 0.55292158 3.61853567 8.879200557 0.002884378 CDC27 996 0.452251264 6.906207954 6.969175742 0.008292569 CDC34 997 0.625385017 5.81040397 5.187735221 0.022746841 CDC42BPA 8476 0.565711135 5.348416533 5.13858483 0.023399715 CDC42EP2 10435 0.471608476 4.866075772 6.367160769 0.011625145 CDC7 8317 0.529655009 3.089763842 6.85718978 0.008828529 CDH1 999 0.719394293 3.136972137 6.42563929 0.011248442 CDK8 1024 0.53351846 4.257630072 8.579052104 0.003400523 CDKL1 8814 0.467528464 3.707194327 4.21152363 0.040150258 CDKN1A 1026 0.466798751 4.237589706 4.112962216 0.042555764 CDKN3 1033 0.719792998 1.966634205 10.55714397 0.001157399 CDYL 9425 0.640524586 6.176591907 5.983038803 0.014444094 CENPH 64946 0.578495898 2.570065039 8.011235206 0.004648802 CENPI 2491 0.67644598 2.317691882 7.860405052 0.005052907 CENPK 64105 0.43948212 4.354889708 4.873896609 0.027265867 CEP57L1 285753 0.571835332 3.666897521 8.01036912 0.004651026 CEP70 80321 0.621645122 3.483134044 9.629135292 0.001915148 CFAP20 29105 0.48898819 2.094094878 5.441290781 0.019666131 CFD 1675 0.424553595 4.251200847 3.884936145 0.048721115 CFH 3075 0.874301683 1.417942466 13.74057816 0.000209871 CHEK2 11200 0.579398738 2.769437997 7.244175143 0.007113138 CISD2 493856 0.717528842 5.681612388 9.613416111 0.00193161 CLEC10A 10462 0.485272386 2.798055715 4.233090161 0.039643201 CLIC2 1193 0.799310616 4.79088696 17.53247776 2.82E-05 CLIC5 53405 0.598646843 1.295549137 6.27695408 0.012231816 COL6A2 1292 0.740710519 2.482446123 6.163162661 0.013043778 COPS3 8533 0.478243621 5.087194205 8.654079227 0.003263299 COX6B1 1340 0.426481508 5.752819159 6.070899987 0.013742692 COX7B 1349 0.538207162 4.472091711 6.089144678 0.013601492 COX7C 1350 0.585451381 5.593082523 8.302519927 0.003959011 CR1L 1379 0.681619239 4.484096448 7.552830495 0.005991589 CTNNAL1 8727 0.508197387 3.976938122 7.285506686 0.006951312 DANCR 57291 0.621322176 2.007607601 7.282741302 0.006962021 DCAF12 25853 0.592279086 10.11724084 5.985403925 0.014424739 DCAF6 55827 0.464095591 6.384970493 5.965964597 0.01458462 DCP1B 196513 0.439406696 2.630461778 3.905993258 0.048114179 DCUN1D1 54165 0.655919937 7.769608282 10.68826064 0.001078175 DDI2 84301 0.605772832 5.558793753 9.067654498 0.002601706 DDT 1652 0.763557459 1.413921977 6.414864756 0.011316895 DDX11L1 100287102 0.420941031 3.668794181 5.621299158 0.017743491 DDX11L9 100288486 0.4491778 3.639243138 6.59434148 0.010230339 DENND4A 10260 0.4225501 8.172641251 4.20062971 0.040408971 DHX40 79665 0.435906244 5.601565583 5.927614577 0.014905405 DNA2 1763 0.574173175 4.709897091 7.07523902 0.00781564 DNAJA4 55466 0.575382273 5.151336323 6.343278656 0.011782689 DNAJB2 3300 0.475838646 5.556294881 4.497255284 0.033949304 DNAJB4 11080 0.754146353 3.610929202 14.445204 0.000144297 DNAJC6 9829 0.878103339 5.910028502 20.50659026 5.94E-06 DPCD 25911 0.679345397 1.650576865 7.247579493 0.007099665 DPM2 8818 0.943540786 4.99586028 13.96961633 0.000185789 DPM3 54344 0.750706331 1.153771773 10.63053655 0.001112354 DPP4 1803 0.414594526 3.732544692 5.442314203 0.019654612 DYRK3 8444 0.82588165 2.68238554 10.0870237 0.001493171 DZIP3 9666 0.50129161 3.947460773 5.149959702 0.023246913 E2F2 1870 0.750954633 6.084654005 6.179259132 0.012925639 ECI2 10455 0.462472251 2.169223805 4.839625165 0.02781294 EDF1 8721 0.409353678 5.015070547 5.819658697 0.01584802 EEF1B2 1933 0.631136286 5.479339732 10.04531526 0.001527359 EGLN2 112398 0.451776134 2.645349739 5.269126805 0.021706899 EIF1B 10289 0.49650886 6.65281203 6.026806476 0.014090203 EIF2AK1 27102 0.517662997 7.901650935 6.192517436 0.012829156 ELOF1 84337 0.576142415 4.361102737 6.878998903 0.00872144 ELOVL6 79071 0.733683515 2.868507461 10.23893123 0.001375072 EMC3 55831 1.092754104 7.164712469 24.21784665 8.60E-07 ENKUR 219670 0.523272356 3.453447954 6.072428231 0.013730807 EPB41 2035 0.737683141 10.83070724 8.111574457 0.004398351 EPB41L4A-AS1 114915 0.414843393 2.063076668 4.252914464 0.039183032 EPB42 2038 0.772668418 5.804275297 6.44663943 0.011116241 EPHX2 2053 0.496752933 2.68207289 4.481947828 0.03425466 ERI3 79033 0.496129075 2.6164772 6.025838376 0.014097934 EXPH5 23086 0.471215907 1.166336506 4.025605094 0.044814541 FAHD2B 151313 0.463663124 1.105886277 4.102892148 0.042809924 FAM104A 84923 0.702554356 6.095354429 12.58240721 0.000389395 FAM104B 90736 0.870534153 1.850742775 12.46650257 0.000414315 FAM210B 116151 0.864455671 8.249624413 15.8915613 6.71E-05 FAM43A 131583 0.491440097 2.094241371 4.614565058 0.031701534 FAM46C 54855 0.663720307 11.40084998 5.449606072 0.01957274 FANCB 2187 0.449937708 2.9205891 5.540823645 0.018577837 FAU 2197 0.457145894 6.723098751 6.038972357 0.013993427 FAXDC2 10826 0.597937843 6.578442428 6.43163055 0.011210562 FBL 2091 0.573285946 4.442102272 10.97897041 0.000921516 FBXO7 25793 0.740674834 10.06965198 7.250791434 0.007086977 FCER1A 2205 1.457705216 4.048666239 12.3059924 0.000451506 FCF1 51077 0.411073932 4.296224877 4.865178095 0.02740397 FCGBP 8857 0.45873878 4.370232935 4.380929624 0.036343171 FCHO2 115548 0.478327102 7.212368679 6.263084422 0.012327939 FECH 2235 1.098618318 8.422127755 24.81042811 6.33E-07 FEM1A 55527 0.413410269 4.792186061 4.156328022 0.041479235 FGFR1OP2 26127 0.441431724 6.431861488 7.195188911 0.00730993 FIP1L1 81608 0.441735124 4.9078258 6.412665134 0.011330922 FIS1 51024 0.57645914 5.112184826 7.975381703 0.004741776 FKBP1B 2281 0.685719326 2.338573254 6.586096254 0.01027783 FOXO4 4303 0.702889714 7.236253414 9.764308676 0.001779324 FUNDC1 139341 0.571125239 2.272544371 5.946951988 0.014742756 FUNDC2 65991 0.431124007 4.014726688 4.55003383 0.032918096 GABARAPL2 11345 0.645203288 7.63571891 10.23889748 0.001375098 GAS5 60674 0.57527637 4.343714587 7.062099479 0.007873168 GATA1 2623 0.628365719 3.970722905 6.179883935 0.012921075 GATA2 2624 0.785358858 3.875541245 9.185018063 0.002440041 GCLC 2729 0.407464358 6.020103247 5.93310193 0.014859064 GLRX5 51218 0.606626548 7.078654739 11.77578855 0.000600061 GMPR 2766 0.46457232 5.848352274 4.016258541 0.045063579 GMPS 8833 0.419458714 4.902418091 4.994056131 0.025434522 GOLGA2P10 80154 0.55083736 2.216101938 5.739516792 0.016587355 GOLGA7B 401647 0.54999593 2.057114014 4.304399443 0.038013915 GPR146 115330 0.72562014 4.076493878 6.5754883 0.010339263 GPR162 27239 0.767580288 2.404766055 3.986612603 0.04586318 GPX1 2876 0.740884515 6.95408674 7.072483195 0.007827669 GPX4 2879 0.533191101 5.004431017 6.445720715 0.011121991 GRAMD1C 54762 0.799714209 3.507914846 7.862018052 0.005048401 GRAP 10750 0.426693634 4.102497804 4.666007479 0.030765369 GSPT1 2935 0.491366247 9.165271338 4.828512287 0.027992776 GUK1 2987 0.583605208 7.694494597 3.926704273 0.047524996 GYPA 2993 1.223887993 5.473853463 37.22901256 1.05E-09 GYPB 2994 1.554003041 4.822649461 79.08579453 5.95E-19 GYPC 2995 0.905970718 9.361329082 10.17723125 0.001421855 GYPE 2996 1.002723007 3.093364887 16.52252595 4.81E-05 GZMH 2999 0.510175602 4.057786724 4.43351073 0.035239951 GZMK 3003 0.641261369 3.161833374 6.555994527 0.01045314 GZMM 3004 0.785717884 2.442293739 10.52188094 0.001179694 H2AFJ 55766 0.536055157 3.592313818 5.083664138 0.024152276 HAGH 3029 0.763849491 6.127928118 11.04952986 0.000887097 HBA1 3039 0.986643307 15.64300321 8.495115954 0.003561011 HBA2 3040 0.971700338 17.01097583 6.264042313 0.012321275 HBB 3043 0.92614198 16.81194849 5.864701167 0.015447481 HBD 3045 1.240271685 7.213858318 20.23404035 6.85E-06 HBG1 3047 2.012110927 10.49011733 44.87676886 2.10E-11 HBG2 3048 2.426537131 11.65658859 43.67827629 3.87E-11 HBM 3042 0.965669282 4.993613357 7.068816285 0.007843706 HBQ1 3049 0.943462756 2.741846306 7.068699286 0.007844218 HDC 3067 0.600566149 3.800257015 5.755957581 0.016432837 HEMGN 55363 1.063819306 8.851796319 19.37652915 1.07E-05 HGD 3081 0.591267352 2.097697918 5.60095318 0.017950709 HIBADH 11112 0.517051932 2.85883333 6.462624792 0.011016679 HIST1H4J 8363 0.609600351 5.502049784 4.345529173 0.037106234 HIST1H4K 8362 0.60360006 5.525031683 4.31873633 0.037694905 HIST3H2BB 128312 0.796458259 3.198128482 15.76996276 7.15E-05 HIST4H4 121504 0.54595167 3.69540607 6.133623201 0.013263479 HLA-DPA1 3113 0.451701798 6.66497645 5.651365981 0.01744178 HMBS 3145 0.681550714 3.004600319 5.909427974 0.015060061 HOOK1 51361 0.435507014 2.609707115 4.035776378 0.044545175 HSF5 124535 0.663476343 1.454758671 8.035064655 0.004588037 HSPB1 3315 0.920490623 3.273859549 7.218451096 0.007215795 ICOS 29851 0.52124818 3.126590898 4.634289048 0.031339126 IFIT1B 439996 0.748122879 6.004486679 14.41153432 0.0001469 IFT52 51098 0.528897478 2.946535526 8.481090896 0.003588568 IFT74 80173 0.406852019 3.995307062 4.21816957 0.039993282 INO80B 83444 0.514887988 1.090439361 5.016122001 0.02511235 ISCA1 81689 0.753742624 6.317198527 16.40415997 5.12E-05 ISPD 729920 0.560299289 3.404246751 8.622010709 0.00332125 ITGB8 3696 0.769637686 2.049492727 7.036108581 0.007988241 JAZF1 221895 0.474927078 7.198217513 6.362133985 0.011658125 KAT2B 8850 0.52901142 7.938903452 8.320898301 0.003919153 KEL 3792 0.663818311 2.630956333 3.971720621 0.046270469 KIAA1586 57691 0.762281776 4.811752755 12.613954 0.000382878 KIF14 9928 0.425663424 4.807137305 4.595980549 0.032047006 KIF15 56992 0.447166225 4.371037156 4.422805323 0.03546169 KIF18A 81930 0.616607624 2.955072598 9.728866538 0.001813963 KIF20B 9585 0.570284748 5.680773959 10.37235367 0.001279164 KIF23 9493 0.489322623 2.88276043 4.489835311 0.034096962 KIT 3815 0.490422666 1.352696475 4.168315132 0.041186738 KLF1 10661 1.176622716 3.72378886 6.437227865 0.011175291 KLRB1 3820 0.612130671 4.08966989 7.019101451 0.008064469 KNL1 57082 0.404517562 4.70463391 3.962900233 0.046513499 KPNA5 3841 0.453302067 3.963558047 5.267633657 0.021725526 KRT1 3848 1.159560503 5.826114243 19.4602436 1.03E-05 LARP1B 55132 0.596907828 5.029763825 11.2357598 0.000802363 LBH 81606 0.413962765 5.850124408 4.070798173 0.043630653 LCK 3932 0.539900841 5.688335842 7.765065888 0.005326635 LDHB 3945 0.44568324 6.093943474 5.795437426 0.016067817 LGALS3 3958 0.804705136 5.773207287 17.65326509 2.65E-05 LIN9 286826 0.429581688 2.644203834 4.690187601 0.030335335 LINC01094 100505702 0.43476749 3.53857541 4.868309619 0.027354283 LNX2 222484 0.437746998 4.345720571 6.064354795 0.013793714 LRRC75A-AS1 125144 0.466625864 6.031889223 6.130768874 0.013284908 LRRN3 54674 0.523772606 3.384317062 8.025362791 0.004612679 LSM7 51690 0.676920153 2.442075813 11.49003365 0.000699704 LYL1 4066 0.796115617 5.573984759 8.406421955 0.003738978 LYRM4 57128 0.542100136 1.587384616 5.357523988 0.020633048 LZTFL1 54585 0.692948327 3.012071045 9.505948323 0.002048069 MAN1A2 10905 0.480136837 7.460091541 6.281388095 0.012201249 MAP1LC3B2 643246 0.412693617 4.367283693 5.6590089 0.017365934 MAP3K7CL 56911 0.704119072 6.273306143 9.562802822 0.001985597 MAP7 9053 0.769960287 1.475636705 8.238256598 0.004101651 MATK 4145 0.641051005 2.52483989 4.595538633 0.032055269 MBLAC2 153364 0.479559674 2.079614276 5.161084633 0.023098468 MBNL3 55796 0.693625585 10.1832763 7.671402144 0.005610284 MCM10 55388 0.536340225 2.588442764 4.814392592 0.028223017 MEIS1 4211 0.567418852 3.207146952 6.617500473 0.010098146 MELK 9833 0.652601232 2.462549013 5.432688331 0.019763233 MID1IP1 58526 0.435283939 4.775117515 5.933259915 0.014857732 MID2 11043 0.545037072 1.85434376 4.136988512 0.041955747 MINPP1 9562 0.654098901 3.87858939 8.46569447 0.003619071 MIR1282 100302254 0.460328004 6.226549407 6.111814869 0.013428117 MIR4444-1 100616394 0.46902835 1.667545299 4.469330497 0.034508511 MKRN1 23608 0.649563066 10.02627097 7.0511833 0.007921291 MKRN9P 400058 0.598308516 4.824917501 7.500616723 0.006167787 MND1 84057 0.607851454 1.650477475 5.010128768 0.025199433 MOB4 25843 0.588685365 1.616799076 6.112796229 0.013420664 MORC3 23515 0.485377258 8.518997375 6.6697308 0.0098064 MOSPD1 56180 0.63402939 4.227427097 10.85851707 0.000983424 MPP1 4354 0.497795405 8.542193431 4.813294615 0.028241003 MPP6 51678 0.579774911 4.822559233 7.281902199 0.006965274 MPZL1 9019 0.416549245 5.564996381 4.459477887 0.034708105 MRC1 4360 0.700192778 1.377887658 7.847249787 0.005089808 MRC2 9902 1.351030046 2.825645151 32.02851714 1.52E-08 MRPL22 29093 0.461883482 2.472697641 4.696863304 0.030217718 MRPL34 64981 0.602940462 1.658131189 7.019952347 0.008060638 MRPL54 116541 0.469318393 2.536638654 4.22466784 0.039840416 MRPL55 128308 0.442440504 1.840107518 4.038207221 0.044481051 MRPL57 78988 0.447584318 2.555756283 4.120497525 0.042366617 MRPS12 6183 0.477527301 1.72238518 4.267234896 0.038854108 MTHFS 10588 0.473626683 1.858002403 4.017238482 0.0450374 MTX2 10651 0.46868856 1.76416667 4.181807739 0.040860095 MXI1 4601 0.560553164 8.620138447 6.217333601 0.012650549 MYBL1 4603 0.44137694 4.673137064 4.21958022 0.039960046 MYL4 4635 0.756652726 5.260656415 7.174791696 0.007393503 MZT2B 80097 0.814265383 2.495634431 13.48359723 0.000240658 NACA 4666 0.485847017 7.905063256 7.677995945 0.005589821 NCOA4 8031 0.560938471 10.84424037 5.001194182 0.025329836 NDUFA3 4696 0.658712025 3.554260242 9.956339269 0.001602965 NDUFA5 4698 0.45530789 4.171510466 4.900161839 0.026854179 NDUFB4 4710 0.418751204 3.792200515 4.111920236 0.042581989 NDUFS4 4724 0.471064879 2.809845821 5.522082234 0.018777895 NDUFS7 374291 0.498045928 2.745105401 4.154710139 0.04151888 NEIL3 55247 0.578054227 6.049408421 9.140998658 0.002499446 NEK1 4750 0.50311471 5.260006385 5.541413382 0.018571578 NELL2 4753 0.45798157 4.302166371 5.550432877 0.018476117 NFIX 4784 0.729125128 5.713986955 8.155510502 0.004293051 NGRN 51335 0.641987642 2.038652759 4.890325873 0.027007588 NME2 4831 0.84078594 1.483878937 8.361919796 0.003831655 NME3 4832 0.520734745 2.186643792 5.053318582 0.02457882 NME4 4833 0.607724368 2.557874612 4.598757453 0.031995137 NOV 4856 0.613818171 2.975056378 5.883096166 0.015286917 NSUN3 63899 0.880929911 6.808358848 17.47632449 2.91E-05 NTAN1 123803 0.476529646 3.947518546 6.413341488 0.011326607 NUBP2 10101 0.600457682 2.048638219 5.491528463 0.01910883 NUP35 129401 0.557796421 3.124344599 8.083979519 0.004465827 NUP54 53371 0.43943555 4.938610926 4.657292371 0.030921917 NUSAP1 51203 0.593619185 4.990090188 9.954854109 0.001604258 ODC1 4953 0.415496799 6.274593806 5.243645281 0.022027073 OPA1 4976 0.638790864 7.078579039 11.17553702 0.000828829 OPTN 10133 0.755127628 7.615831329 10.49208255 0.001198872 ORC5 5001 0.435840861 3.321023193 4.498095962 0.033932617 OSBP2 23762 0.948937822 6.690123084 8.202632627 0.004182965 OTUD7B 56957 0.424206299 3.046893997 4.232584163 0.039655021 PAK1IP1 55003 0.500106435 2.231687002 5.971296471 0.014540587 PARPBP 55010 0.570161666 2.979262405 5.492229007 0.019101176 PCMTD1 115294 0.44618256 8.090270952 6.232727221 0.012541044 PCTP 58488 0.491674233 4.585790029 8.636951451 0.003294122 PDE2A 5138 0.477220054 1.374457855 4.443597751 0.035032349 PDZD4 57595 0.580850055 2.526243636 7.493892975 0.006190858 PDZK1IP1 10158 1.059448273 5.348912151 12.51755399 0.000403146 PFDN4 5203 0.55600621 2.166251478 5.822002805 0.015826913 PFDN5 5204 0.449528074 7.340470223 6.337451866 0.011821459 PGM2L1 283209 0.50080683 5.121821641 6.813744242 0.009045889 PHF7 51533 0.530840133 2.748229449 4.132856326 0.042058305 PHLPP2 23035 0.56348979 5.111199439 5.774890856 0.01625673 PHPT1 29085 0.518645087 2.188504199 4.304925489 0.03800216 PIGC 5279 0.778827784 5.721901866 9.324595225 0.002260983 PIP4K2A 5305 0.514933799 9.340162916 5.892832949 0.015202625 PITHD1 57095 0.695030347 6.380504848 8.355837739 0.003844502 PLEK2 26499 0.86629289 3.741304764 10.53288956 0.001172687 PLEKHA5 54477 0.515084461 1.920033933 4.502959397 0.033836246 PLVAP 83483 1.144326201 3.196630522 8.075749446 0.004486155 PMAIP1 5366 0.499854552 3.062532315 3.907056104 0.048083756 POC1B 282809 0.521084151 5.92055886 10.71561704 0.00106235 POLE2 5427 0.719331628 3.66231628 12.75056767 0.000355901 POLL 27343 0.544647379 5.168476967 6.034902193 0.014025728 POLR1D 51082 0.760489952 5.968021396 14.74250332 0.000123237 POLR2I 5438 0.593193485 1.537045378 6.06565052 0.013783598 PPDPF 79144 1.068287141 4.805622652 6.650130483 0.009914856 PPIAL4A 653505 0.606833684 2.853166314 3.895438837 0.048417389 PRDX2 7001 0.640777038 4.693571191 7.430159668 0.006413965 PRDX6 9588 0.793585956 7.533608437 18.77946824 1.47E-05 PRELID2 153768 0.84423232 2.213214541 8.172316179 0.004253456 PRIM1 5557 0.454893307 3.108135653 5.712198322 0.016847429 PRR5 55615 0.47393983 3.184003459 4.089747111 0.043144097 PRR5L 79899 0.539568513 4.629185484 4.369213572 0.036593877 PSME4 23198 0.427182406 7.617692969 5.271592113 0.021676179 PSMF1 9491 0.666682166 7.269091378 7.047771835 0.007936391 PTP4A3 11156 0.550073657 3.412540098 7.065341984 0.007858931 PTPN4 5775 0.431980466 6.701024547 5.563009682 0.018343852 PTPRA 5786 0.44395539 6.725002858 5.293045476 0.021410746 PTPRCAP 5790 0.574701163 4.351781016 5.632653949 0.017628922 PTRHD1 391356 0.673160836 1.276918172 7.68719503 0.0055614 PUS7 54517 0.450979806 2.696806469 4.218679854 0.039981256 RAB23 51715 0.653593959 2.874354644 8.632126534 0.003302858 RAB2B 84932 0.878445326 7.003064079 17.53653044 2.82E-05 RAB6A 5870 0.475547415 6.438187263 8.329938074 0.003899699 RAB6C 84084 0.610453679 1.773073966 8.841145562 0.002945142 RABGAP1L 9910 0.481595456 7.995281914 5.080031738 0.024202927 RAD23A 5886 0.739028384 5.900349875 11.6559192 0.000639986 RAP2A 5911 0.456915911 5.052594295 5.401195744 0.02012296 RASGRP3 25780 0.524070646 4.180073042 4.632745554 0.03136733 RBM38 55544 0.689266943 8.418262964 3.924736524 0.047580646 RBX1 9978 0.697648118 4.23664912 13.30933191 0.000264088 RCL1 10171 0.68844876 4.210102245 9.673744552 0.0018692 REXO2 25996 0.670334602 4.276056757 14.13384774 0.000170253 RFESD 317671 0.993229616 1.690966424 13.18155265 0.000282718 RGCC 28984 0.63072939 4.240518847 11.83630095 0.000580871 RGS10 6001 0.784874555 6.395864257 14.04801789 0.000178202 RHAG 6005 0.83384651 2.687698365 11.92787419 0.000553002 RHEB 6009 0.698760593 3.574001598 13.17303316 0.000284007 RHOB 388 0.40316129 5.313648382 4.133100504 0.042052237 RIDA 10247 0.672612913 1.486060788 8.892137386 0.002864013 RILP 83547 0.513739606 3.606291152 4.57965455 0.032353737 RIOK3 8780 0.707292155 9.663893078 8.955151482 0.002766882 RMRP 6023 0.61290909 10.77656515 6.359780325 0.0116736 RNF11 26994 0.566136642 8.918815561 6.119697751 0.013368366 RNF14 9604 0.80436006 6.431073737 23.41815276 1.30E-06 RNF182 221687 0.553393634 5.913051452 4.495999849 0.03397424 RORC 6097 0.524985625 1.350489604 4.678186879 0.030547974 RPIA 22934 0.865318803 6.203344732 14.69077364 0.000126665 RPL10 6134 0.572199383 6.90146145 7.698306353 0.005527267 RPL10A 4736 0.491637069 6.584876505 6.685642789 0.009719247 RPL11 6135 0.480804059 8.160253447 6.214891181 0.012668014 RPL12 6136 0.957521422 6.896095745 22.44841601 2.16E-06 RPL13 6137 0.412137927 7.345269718 4.703223806 0.030106096 RPL13A 23521 0.436656737 6.692526384 5.209544709 0.022463216 RPL13AP20 387841 0.759920403 2.761524528 12.25427716 0.000464193 RPL14 9045 0.654142678 5.896491162 10.02158817 0.00154716 RPL18 6141 0.538527645 6.956209427 8.587906477 0.003384028 RPL18A 6142 0.642304764 4.991627392 9.939488229 0.001617705 RPL19 6143 0.445751039 7.628584513 5.658042002 0.01737551 RPL22 6146 0.505400663 7.010189081 6.576020951 0.01033617 RPL23 9349 0.571415855 7.454555409 7.661687373 0.005640573 RPL23A 6147 0.527280287 5.889204583 9.479108847 0.002078249 RPL23P8 222901 0.687747113 2.825188958 7.768309162 0.00531708 RPL26 6154 0.647619836 6.755190776 13.28683062 0.000267277 RPL27 6155 0.579572132 6.811099949 7.257669863 0.007059883 RPL28 6158 0.427564897 7.04405348 5.124778673 0.023586578 RPL3 6122 0.410633142 7.570625436 4.809174462 0.028308604 RPL30 6156 0.746425795 8.43678469 13.00314182 0.000310969 RPL31 6160 0.712699254 7.774129905 16.58861125 4.64E-05 RPL32 6161 0.490881683 6.778719376 6.771458852 0.009262709 RPL35 11224 0.610896357 5.069816579 8.685137103 0.003208154 RPL35A 6165 0.764253595 7.664801209 16.30627924 5.39E-05 RPL36 25873 0.498572301 6.779887706 7.409721904 0.006487235 RPL37 6167 0.682965174 8.2421836 10.15321281 0.0014405 RPL37A 6168 0.64871996 8.27485841 8.943532508 0.002784537 RPL38 6169 0.615760988 7.634615248 11.47432336 0.000705643 RPL41 6171 0.708347786 8.374295707 12.4950095 0.000408041 RPL5 6125 0.471174541 7.031422613 6.274829496 0.01224649 RPL6 6128 0.557504044 7.120520669 9.266023451 0.00233444 RPL7 6129 0.772042361 6.58203779 18.11270696 2.08E-05 RPL7A 6130 0.576936131 7.118324009 9.810446546 0.001735234 RPL8 6132 0.476981634 7.177562963 6.15330762 0.013116657 RPL9 6133 0.405323566 5.626499803 4.288138709 0.038379159 RPLP2 6181 0.500080868 8.047989975 6.94471313 0.008406732 RPPH1 85495 0.705081123 10.41940342 8.704923019 0.003173518 RPS11 6205 0.545237688 8.171811368 8.800466462 0.003011535 RPS12 6206 0.711859828 8.042610679 12.53247632 0.000399939 RPS13 6207 0.679501861 6.720901273 10.60700208 0.001126602 RPS14 6208 0.626661454 7.833309272 11.20490651 0.000815813 RPS14P3 644068 0.433475536 1.616692845 4.131226727 0.042098823 RPS15 6209 0.528389304 4.858958747 4.56741442 0.032585712 RPS15A 6210 0.808703884 7.091571412 16.08959496 6.04E-05 RPS17 100505503 0.837677434 8.58724365 13.55246644 0.000231986 RPS18 6222 0.553004147 5.267708589 6.39735825 0.011429031 RPS18P9 645958 0.461272377 4.75898971 7.108268859 0.007672917 RPS19 6223 0.694366236 7.572646929 14.3180387 0.000154378 RPS20 6224 0.556506123 7.72526672 9.434178909 0.002129784 RPS21 6227 0.727818165 5.780888695 10.73669575 0.001050317 RPS23 6228 0.729263168 7.578385417 11.99470184 0.00053352 RPS24 6229 0.691157485 8.232042868 13.8848752 0.000194356 RPS25 6230 0.794371078 7.348869082 20.42772909 6.19E-06 RPS27 6232 0.647230222 4.274762405 9.24568084 0.002360515 RPS27L 51065 0.50333177 3.796799205 6.633366272 0.010008594 RPS29 6235 0.867480363 7.269315154 13.05134404 0.000303067 RPS3 6188 0.561285787 7.490048963 8.375913586 0.003802264 RPS3A 6189 0.640966659 7.335274074 11.28651936 0.000780719 RPS4X 6191 0.488563804 7.945251501 7.265167501 0.007030471 RPS5 6193 0.708989191 6.110752697 11.27570798 0.000785279 RPS8 6202 0.554676271 6.80041692 7.558956638 0.005971255 RPSA 3921 0.495226564 6.507511894 7.025018968 0.008037862 RPSAP58 388524 0.40115121 7.75746449 4.874881392 0.027250314 RPSAP9 653162 0.798555377 4.087301594 13.52554497 0.000235338 RRP9 9136 0.717739748 1.374777108 7.897532153 0.004950229 RSRC1 51319 0.703608731 5.363665477 12.35206534 0.000440499 RUNDC3A 10900 0.597868676 5.050503162 5.675424996 0.017204172 S1PR1 1901 0.479011237 5.47806794 6.15127957 0.013131706 SBDS 51119 0.668979109 4.669492174 14.30194422 0.000155704 SBDSP1 155370 0.761582934 3.912445831 17.76416134 2.50E-05 SCARNA12 677777 0.465296893 6.052100768 5.815467079 0.015885834 SCARNA17 677769 0.433747667 6.017743458 5.343038665 0.020805177 SCARNA2 677766 0.744428774 6.982043531 15.66768725 7.55E-05 SCARNA21 677763 0.474588457 7.977829234 5.48307317 0.019201472 SCARNA5 677775 0.471335492 4.570499512 7.699325041 0.005524148 SCARNA6 677772 0.626775963 4.529991046 10.55419574 0.001159246 SCOC 60592 0.523263658 3.317606236 6.081907532 0.013657322 SELENBP1 8991 0.719296987 7.057837527 7.996549525 0.004686658 SELK 58515 0.865271414 4.644591383 26.73904423 2.33E-07 SEMA4F 10505 0.466103537 2.290512333 4.095563453 0.042995897 SEPW1 6415 0.421262989 3.317311277 4.84713513 0.02769209 SERF2 10169 0.457975449 7.018232283 5.099958569 0.023926415 SERTAD1 29950 0.461322568 2.093306968 4.525167227 0.033399811 SESN3 143686 0.550170514 8.640099864 8.176478459 0.004243707 SFRP2 6423 0.836906958 2.294430608 6.012472514 0.01420511 SGIP1 84251 0.998348543 2.090663955 7.274900661 0.006992476 SGK1 6446 0.598073729 5.960977764 5.11173222 0.023764582 SH2D1A 4068 0.516679883 3.738087301 4.653678017 0.030987085 SH3D21 79729 0.566930922 1.826832955 4.524575549 0.033411363 SHISA4 149345 1.191469264 2.499923528 11.26130909 0.000791394 SIT1 27240 0.563859504 3.230966075 7.543714801 0.006021976 SKA3 221150 0.457307083 5.023192189 5.067696867 0.02437575 SKP1 6500 0.650595932 6.911527192 16.37679347 5.19E-05 SKP1P2 728622 0.795883338 2.913605694 14.98080371 0.00010861 SLC14A1 6563 0.814395859 5.968478197 13.53023565 0.000234751 SLC16A1 6566 0.405096053 3.489267763 5.118426843 0.023673068 SLC18B1 116843 0.449073552 4.292511312 3.954293467 0.04675194 SLC1A5 6510 0.476980851 5.405840213 4.35720027 0.036852825 SLC25A38 54977 0.432410345 4.02107519 4.372250439 0.036528719 SLC25A39 51629 0.66119395 9.413881693 5.094215396 0.024005772 SLC25A51 92014 0.621771226 4.084298247 10.99867259 0.000911772 SLC25A6 293 0.428592791 7.394910788 5.50026028 0.019013643 SLC2A1 6513 0.530327851 5.590900633 5.997542534 0.01432582 SLC4A1 6521 0.679735051 9.442937855 5.73828672 0.016598976 SLC4A10 57282 0.861658385 1.807021427 12.4565854 0.000416521 SLC9B2 133308 0.493099994 2.423311623 4.783151247 0.028739482 SLFN14 342618 0.756215531 4.820939739 9.801136701 0.00174404 SMIM5 643008 0.569310254 3.848670332 6.610954491 0.010135332 SNAPC2 6618 0.506341164 1.274425508 5.270355396 0.021691584 SNCA 6622 0.891859827 9.915326753 11.4198362 0.000726641 SNHG8 100093630 0.695298313 3.301723084 8.442399811 0.003665722 SNORA24 677809 0.477284012 1.839620797 3.927844528 0.04749278 SNORA57 692158 0.55375772 4.380053218 4.163226675 0.041310636 SNRPD2 6633 0.458149921 4.477288084 5.348066443 0.020745264 SNRPG 6637 0.42579709 2.903287593 4.888766069 0.027032 SOD1 6647 0.459484335 4.64900941 6.978171283 0.008250988 SOX6 55553 0.842318674 6.55583716 12.88388727 0.000331423 SPACA6 147650 0.504222553 2.374467653 4.68095725 0.030498749 SPIB 6689 0.515130342 2.927614885 5.165452665 0.023040452 SPTA1 6708 0.669347788 5.191343472 6.805779478 0.009086328 SRRD 402055 0.513692997 4.204500178 5.474133137 0.01929993 SSSCA1 10534 0.693882977 1.110425141 8.890763928 0.002866168 ST13 6767 0.727500885 7.072245706 10.76168851 0.001036228 ST13P4 145165 0.666806493 5.094982433 8.516077116 0.003520225 ST6GALNAC4 27090 0.829799512 4.347936013 13.46437686 0.000243136 STIL 6491 0.531609281 5.869682825 4.997802541 0.025379522 STMN3 50861 0.450037338 3.692587328 6.45317909 0.011075399 STOML2 30968 0.53662354 3.428650841 7.774430906 0.005299091 STRADB 55437 0.958659204 8.148104792 26.43736106 2.72E-07 STRN3 29966 0.438738493 6.259363707 5.82464744 0.015803136 SVBP 374969 0.452496099 3.048905848 5.042370012 0.024734628 SWT1 54823 0.682016913 6.583770807 12.8799989 0.000332112 TADA2A 6871 0.401222083 3.288211202 4.088433171 0.04317765 TANK 10010 0.44958668 6.760073992 7.120873555 0.007619157 TBC1D31 93594 0.420938392 5.430621904 4.225820431 0.039813367 TBCEL 219899 0.745167113 7.290474543 11.96225513 0.000542891 TBPL1 9519 0.481189759 4.60933134 6.985567823 0.008216958 TCEANC 170082 0.437877027 3.482438704 4.852980189 0.027598409 TCEB2 6923 0.745409884 5.74486127 20.30120713 6.62E-06 TCP11L2 255394 0.558413729 8.354101648 9.948319184 0.001609963 TDRKH 11022 0.50838694 1.680537977 4.300093992 0.038110267 TERC 7012 0.716999844 2.41177892 4.318786315 0.037693798 TESC 54997 0.875244974 5.321840943 9.559401431 0.00198928 TEX9 374618 0.721507433 3.278973354 11.17500627 0.000829066 TFPI 7035 0.483197801 3.327503629 4.158086231 0.041436197 TFRC 7037 0.450420198 7.251083246 4.008979321 0.045258542 THBD 7056 0.463571037 4.007186274 5.693591734 0.01702697 TIGD3 220359 0.865987609 2.486943101 8.808953456 0.002997559 TIMM23 100287932 0.465995503 4.673416967 5.002970811 0.02530385 TIPIN 54962 0.506441497 2.229262997 4.524585714 0.033411164 TMA7 51372 0.509614874 4.451340222 5.95415857 0.014682609 TMC5 79838 0.597212929 5.211722973 5.290630235 0.021440459 TMEM204 79652 0.531557664 2.810553807 4.777206399 0.028838869 TMEM56 148534 0.563848197 4.536120644 7.029463686 0.008017936 TMEM63B 55362 0.451505039 5.729631059 4.08009176 0.043391302 TMEM9B 56674 0.403231664 4.543119777 5.875564589 0.015352449 TNFRSF25 8718 0.41267788 4.060701714 4.368629865 0.036606415 TNFRSF9 3604 0.404028859 3.333314716 5.033434098 0.024862554 TOMM7 54543 0.461449019 5.977180017 6.953392174 0.008366045 TPGS2 25941 0.62899285 5.392014983 6.506908729 0.010745615 TPT1 7178 0.481335826 10.1550457 4.612233566 0.03174466 TRAK2 66008 0.745762192 8.662773223 9.740321391 0.001802694 TRAPPC5 126003 0.569811195 3.748999292 4.26140044 0.038987767 TRIM10 10107 1.085254945 3.949771796 12.73603393 0.000358677 TRIM23 373 0.634335265 5.571823002 13.46764803 0.000242712 TRMT61A 115708 0.775649695 1.603569107 11.21287569 0.000812317 TSPAN5 10098 0.693912206 6.391495798 9.828722068 0.001718077 TSSC4 10078 0.458987603 3.33660672 5.695587862 0.017007615 TSTA3 7264 0.483743828 5.025159689 6.173516072 0.012967663 TUBB2A 7280 1.139935851 4.896124123 18.06705983 2.13E-05 TXNDC16 57544 0.566465294 5.01013238 9.12342935 0.002523565 UBA52 7311 0.932228058 9.081827683 18.44491562 1.75E-05 UBAP2 55833 0.477318039 6.907805592 6.308788526 0.012014091 UBASH3A 53347 0.430017603 3.847228903 3.904406837 0.048159625 UBB 7314 0.876967361 11.76241373 8.632397837 0.003302366 UBE2H 7328 0.452421185 7.867394116 6.417828776 0.011298021 UBE2V1 7335 0.782517625 3.499566233 10.83014209 0.00099861 UBL7 84993 0.465563769 4.406542702 4.705283075 0.030070049 UBXN2A 165324 0.439476128 3.582054606 4.653416261 0.03099181 UFC1 51506 0.420899406 4.266279077 5.272377331 0.021666404 UFSP2 55325 0.555750598 2.445842962 7.594038025 0.005856163 UQCRB 7381 0.650262574 6.562875992 14.18450428 0.00016573 UROS 7390 0.519584286 3.017571402 5.36979549 0.02048838 USP12 219333 0.741019133 7.531469514 13.41636478 0.000249439 VRK1 7443 0.530355879 6.211874586 5.914982837 0.015012649 WDR78 79819 0.681414028 2.139979162 6.313977877 0.011978978 WTH3DI 150786 0.557007204 1.547274968 4.738300491 0.029498198 XK 7504 0.658713525 6.730502761 8.980664489 0.002728514 XPO7 23039 0.464860283 7.544744601 5.368479498 0.020503843 YBX1 4904 0.849719047 8.103313225 13.42044741 0.000248896 YBX3 8531 0.656710952 8.846427872 5.752030393 0.016469611 YIPF6 286451 0.598824489 5.755116756 12.48250758 0.00041078 YOD1 55432 0.655367412 9.364017994 8.876560046 0.002888553 ZFAND4 93550 0.509030873 5.01786812 7.32097945 0.006815426 ZFYVE9 9372 0.456198583 1.642805904 4.118268424 0.042422478 ZNF175 7728 0.508927485 2.8863888 6.213677125 0.012676704 ZNF23 7571 0.940002924 4.600869181 18.71742134 1.52E-05 ZNF286A 57335 0.41559062 3.041566923 4.854013997 0.027581874 ZNF428 126299 0.568048305 1.677414608 4.818216998 0.028160461 ZNF542P 147947 0.544930241 3.030436833 6.894650876 0.008645405 ZNF566 84924 0.403255892 3.192291262 4.076925475 0.043472693 ZNF569 148266 0.501197383 3.360273232 5.755182424 0.016440089 ZNF577 84765 0.429046937 3.294132245 3.935451443 0.047278449 ZNF681 148213 0.486925654 2.309208903 4.421858239 0.035481376 ZNF790-AS1 284408 0.459752277 1.0005438 3.869443507 0.049172823 Table S4: Gene Ontologies with significant enrichment for genes repressed in response to LDAA treatment. category over_represented_pvalue numDEInCat numInCat term ontology GO:0051607 1.21E-11 30 161 defense response to virus BP GO:0098542 1.62E-11 37 239 defense response to other organism BP GO:0045087 3.50E-11 64 610 innate immune response BP GO:0006952 6.56E-11 84 931 defense response BP GO:0006955 7.24E-11 84 933 immune response BP GO:0060337 1.41E-09 16 56 type I interferon signaling pathway BP GO:0071357 1.41E-09 16 56 cellular response to type I interferon BP GO:0034340 1.89E-09 16 57 response to type I interferon BP GO:0009615 1.94E-09 33 233 response to virus BP GO:0043207 6.25E-09 48 448 response to external biotic stimulus BP GO:0051707 6.25E-09 48 448 response to other organism BP GO:0045071 1.13E-08 12 34 negative regulation of viral genome replication BP GO:0009607 2.42E-08 48 468 response to biotic stimulus BP GO:0048525 3.30E-08 15 60 negative regulation of viral process BP GO:0002252 4.04E-08 45 431 immune effector process BP GO:0009605 7.20E-08 85 1103 response to external stimulus BP GO:0034097 7.65E-08 44 421 response to cytokine BP GO:0071345 1.09E-07 39 353 cellular response to cytokine stimulus BP GO:0019221 2.27E-07 33 279 cytokine-mediated signaling pathway BP GO:0043901 6.71E-07 16 84 negative regulation of multi-organism process BP GO:0045069 1.04E-06 12 49 regulation of viral genome replication BP GO:0031224 2.85E-08 166 2615 intrinsic component of membrane CC GO:0016021 9.59E-08 162 2580 integral component of membrane CC GO:0005886 2.35E-07 138 2142 plasma membrane CC GO:0044425 4.30E-07 190 3223 membrane part CC GO:0071944 5.33E-07 139 2193 cell periphery CC Table S5: Gene Ontologies with significant enrichment for genes over-expressed in response to LDAA treatment. category over_represented_pvalue numDEInCat numInCat term ontology GO:0006415 6.20E-32 59 91 translational termination BP GO:0043624 2.18E-30 67 151 cellular protein complex disassembly BP GO:0043241 4.75E-28 67 171 protein complex disassembly BP GO:0000184 6.61E-28 59 114 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay BP GO:0006613 2.92E-27 58 105 cotranslational protein targeting to membrane BP GO:0032984 5.86E-27 67 181 macromolecular complex disassembly BP GO:0006414 8.34E-27 58 113 translational elongation BP GO:0006614 1.42E-26 57 103 SRP-dependent cotranslational protein targeting to membrane BP GO:0045047 4.46E-26 57 106 protein targeting to ER BP GO:0072599 4.46E-26 57 106 establishment of protein localization to endoplasmic reticulum BP GO:0070972 3.47E-24 57 119 protein localization to endoplasmic reticulum BP GO:0019083 1.21E-23 61 150 viral transcription BP GO:0006612 1.39E-23 62 160 protein targeting to membrane BP GO:0019080 3.63E-23 62 159 viral gene expression BP GO:0022411 1.20E-22 74 309 cellular component disassembly BP GO:0006413 1.33E-22 60 156 translational initiation BP GO:0044033 1.84E-22 62 167 multi-organism metabolic process BP GO:0000956 1.99E-20 60 178 nuclear-transcribed mRNA catabolic process BP GO:0090150 1.08E-19 68 257 establishment of protein localization to membrane BP GO:0006402 1.09E-19 60 189 mRNA catabolic process BP GO:0072657 1.78E-18 70 301 protein localization to membrane BP GO:0006401 2.98E-18 61 214 RNA catabolic process BP GO:0006605 1.12E-17 80 434 protein targeting BP GO:1902578 1.96E-17 72 343 single-organism localization BP GO:1902580 1.96E-17 72 343 single-organism cellular localization BP GO:0019058 3.08E-16 66 284 viral life cycle BP GO:0072594 3.73E-16 75 400 establishment of protein localization to organelle BP GO:0044802 5.56E-16 83 510 single-organism membrane organization BP GO:0033365 2.08E-15 83 522 protein localization to organelle BP GO:0061024 7.57E-13 85 623 membrane organization BP GO:0006886 5.98E-12 85 655 intracellular protein transport BP GO:0034613 6.08E-12 103 920 cellular protein localization BP GO:0070727 7.28E-12 103 924 cellular macromolecule localization BP GO:1902582 4.81E-11 109 1013 single-organism intracellular transport BP GO:0006412 6.04E-11 72 451 translation BP GO:0016482 8.54E-11 86 717 cytoplasmic transport BP GO:0016032 1.14E-10 83 626 viral process BP GO:0044764 1.49E-10 83 632 multi-organism cellular process BP GO:0044265 2.57E-10 86 719 cellular macromolecule catabolic process BP GO:0044403 1.06E-09 84 668 symbiosis, encompassing mutualism through parasitism BP GO:0044419 1.06E-09 84 668 interspecies interaction between organisms BP GO:0008104 1.94E-09 127 1415 protein localization BP GO:0019439 2.26E-09 107 1135 aromatic compound catabolic process BP GO:0071822 3.41E-09 103 1017 protein complex subunit organization BP GO:1901361 3.66E-09 107 1145 organic cyclic compound catabolic process BP GO:0009057 4.21E-09 90 838 macromolecule catabolic process BP GO:0045184 5.79E-09 112 1185 establishment of protein localization BP GO:0046700 7.01E-09 105 1131 heterocycle catabolic process BP GO:0016071 7.17E-09 75 587 mRNA metabolic process BP GO:0044270 9.00E-09 105 1135 cellular nitrogen compound catabolic process BP GO:0034655 1.20E-08 103 1114 nucleobase-containing compound catabolic process BP GO:0046907 2.47E-08 112 1198 intracellular transport BP GO:0015031 4.21E-08 104 1110 protein transport BP GO:0044765 5.23E-08 165 2120 single-organism transport BP GO:0033036 8.08E-08 133 1627 macromolecule localization BP GO:0051234 1.03E-07 193 2648 establishment of localization BP GO:0051641 1.41E-07 141 1763 cellular localization BP GO:0044248 1.50E-07 145 1861 cellular catabolic process BP GO:0071702 3.56E-07 128 1582 organic substance transport BP GO:0043933 4.00E-07 106 1168 macromolecular complex subunit organization BP GO:0009056 4.85E-07 154 2063 catabolic process BP GO:0006810 5.77E-07 186 2587 transport BP GO:0051179 1.14E-06 213 3126 localization BP GO:0051649 1.82E-06 126 1558 establishment of localization in cell BP GO:0044267 2.54E-06 194 2812 cellular protein metabolic process BP GO:0022626 5.27E-32 58 87 cytosolic ribosome CC GO:0044445 1.08E-25 66 171 cytosolic part CC GO:0044391 1.21E-25 61 121 ribosomal subunit CC GO:0022625 3.06E-21 35 49 cytosolic large ribosomal subunit CC GO:0005840 1.61E-20 66 185 ribosome CC GO:0015934 4.84E-18 37 66 large ribosomal subunit CC GO:0022627 1.35E-12 23 35 cytosolic small ribosomal subunit CC GO:0005829 1.93E-10 173 2098 cytosol CC GO:0015935 4.59E-09 24 55 small ribosomal subunit CC GO:0030529 9.25E-09 77 557 ribonucleoprotein complex CC GO:0005924 2.96E-08 42 296 cell-substrate adherens junction CC GO:0005925 2.96E-08 42 296 focal adhesion CC GO:0030055 4.83E-08 42 299 cell-substrate junction CC GO:0005912 1.17E-07 43 328 adherens junction CC GO:0070161 1.70E-07 43 335 anchoring junction CC GO:0005833 2.46E-06 8 9 hemoglobin complex CC GO:0003735 5.59E-24 63 135 structural constituent of ribosome MF GO:0005198 1.96E-18 76 329 structural molecule activity MF Table S6: AZA, genes repressed on treatment compared to pretreatment.

Gene Symbol Entrez ID logFC logCPM LR PValue ABCB10 23456 -0.578831341 5.719634584 7.263751605 0.007036016 ABCC4 10257 -0.566004187 6.588438342 4.639131045 0.031250822 ABCG2 9429 -0.7286559 3.464301469 6.09617636 0.013547471 ACP1 52 -0.732446721 5.864538891 9.551936354 0.001997386 ADIPOR1 51094 -1.097035124 10.21497187 7.024041179 0.008042252 AGO2 27161 -0.595446776 6.113790949 8.982018173 0.002726493 AIDA 64853 -0.565876541 6.683462608 7.342201527 0.00673543 ALAS2 212 -1.388860422 11.0545216 4.62647652 0.031482154 ALDH2 217 -0.594944457 5.155950266 6.06682517 0.013774433 ALDH5A1 7915 -0.831530043 5.852401264 11.04840985 0.000887633 ALPL 249 -0.446061315 7.088318569 4.6702003 0.030690348 ANK1 286 -1.113616242 7.347317747 8.0520465 0.004545228 ANKRD22 118932 -0.937687655 3.036111826 8.27767773 0.004013543 ANLN 54443 -0.901378615 2.958290134 6.374710531 0.011575792 ANXA3 306 -0.632424268 6.744138887 4.487777906 0.034138024 AP2A1 160 -0.778891594 6.543330132 8.435333819 0.003679993 AP2B1 163 -0.525517581 7.200768661 5.225767768 0.02225462 APOPT1 84334 -0.562394672 2.04909364 3.969925636 0.046319818 ARG2 384 -0.473216865 3.947300997 4.636338689 0.031301715 ARHGAP24 83478 -0.61501936 4.075327539 5.188303886 0.022739399 ARHGAP42 143872 -0.485214101 2.864002572 5.705780913 0.016909131 ARHGEF12 23365 -1.040861021 8.500353029 10.30811351 0.001324466 ARHGEF37 389337 -0.956450288 2.150330519 5.612386647 0.017833957 ARL4A 10124 -0.778972174 7.277942093 8.823857539 0.002973175 ARL6IP1 23204 -0.593969077 7.913468513 5.433933892 0.019749143 ASCC2 84164 -0.968897152 7.649640091 6.826676514 0.008980622 ASPM 259266 -0.705548871 4.254872814 5.065737424 0.024403321 ATAD2 29028 -0.440012512 5.251214974 4.389705224 0.036156564 ATG9A 79065 -0.501352769 4.719910637 6.247150956 0.012439323 ATP23 91419 -0.49652699 2.682582313 6.912983512 0.008557209 ATP6V0C 527 -0.634048009 3.111287014 4.521713175 0.033467303 AURKA 6790 -0.55004661 3.554349221 4.866536386 0.027382407 BABAM1 29086 -0.648624412 5.240475248 4.809695074 0.028300052 BAG1 573 -0.811143752 7.993799168 4.669132087 0.030709443 BAG6 7917 -0.660487807 7.031798974 6.86477696 0.008791122 BBOF1 80127 -0.734956513 5.735979867 4.649675445 0.031059419 BCL11A 53335 -0.470233551 3.011569727 5.653259471 0.017422958 BCL2L1 598 -1.181708841 9.580569657 8.729378422 0.003131232 BCL2L13 23786 -0.537356252 5.908717831 6.120022409 0.013365911 BIRC2 329 -0.858931246 8.169332052 15.82106067 6.96E-05 BLVRB 645 -1.045416935 7.476479834 5.878718839 0.015324969 BMX 660 -0.635792577 3.770803165 4.64345073 0.031172263 BNIP3L 665 -0.893239499 11.9627078 4.150364813 0.041625555 BPGM 669 -0.989163535 8.63881213 7.144149554 0.007520893 BPI 671 -1.037092415 5.024246114 3.88237338 0.048795532 BRCA2 675 -0.508726259 3.928952611 5.383331947 0.020330015 BRD4 23476 -0.629623321 6.153648835 8.04346019 0.004566822 BRIP1 83990 -0.590622018 3.800861221 5.490768055 0.019117143 BSG 682 -0.887385101 7.976164191 5.731741026 0.016660957 BUB1 699 -0.819377404 2.435419468 5.134574837 0.023453831 C11orf42 160298 -0.549782797 1.270684869 5.166156571 0.023031117 C20orf196 149840 -0.53460371 3.005646047 4.99227865 0.02546066 C5 727 -0.46764116 2.46253285 5.921158682 0.014960117 C7orf73 647087 -0.549989765 7.149843893 4.994631109 0.025426073 C9orf40 55071 -0.71946856 4.244774999 6.449358725 0.01109924 C9orf78 51759 -0.911883567 8.485044267 6.446286981 0.011118447 CAMP 820 -1.117161504 6.162642157 4.092018296 0.043086163 CAPN5 726 -0.795312681 2.57563325 7.264274173 0.007033969 CARM1 10498 -0.931732204 4.932770156 9.978790334 0.001583537 CCDC18 343099 -0.400796681 6.097771979 3.999954253 0.045501499 CCNDBP1 23582 -0.616826374 7.365982628 6.066403897 0.013777719 CCNI 10983 -0.666169573 8.263633482 6.835484449 0.008936445 CD163 9332 -0.704738865 5.898512168 6.894820648 0.008644584 CD19 930 -0.512830547 1.886985023 5.020751816 0.025045292 CD55 1604 -0.437779795 7.544504544 4.0656258 0.043764466 CD79A 973 -0.450831776 3.874966939 5.548991246 0.018491341 CDC27 996 -0.5620212 7.237782043 7.918701306 0.004892638 CDC34 997 -1.016375315 6.148871141 8.136018891 0.004339446 CDC42BPA 8476 -0.579684453 5.588185521 5.149587109 0.023251901 CDC7 8317 -0.490359969 3.231860873 4.388876295 0.036174148 CDH1 999 -0.803337562 3.054413824 5.925216711 0.014925703 CDKL1 8814 -0.456041664 3.812998832 5.326178076 0.021007403 CDKN2D 1032 -0.457356756 6.184793207 4.030931239 0.044673275 CDKN3 1033 -0.504056458 2.059934775 4.702977142 0.030110417 CEACAM8 1088 -1.292509046 5.644717031 4.72736784 0.029686283 CEBPD 1052 -0.436094044 5.106279797 4.055373425 0.044030979 CENPE 1062 -0.58821504 4.482178266 4.049298519 0.044189704 CENPH 64946 -0.516141046 2.773987198 7.702446224 0.005514604 CENPI 2491 -0.622572476 2.593612936 4.147532913 0.041695231 CEP57L1 285753 -0.404084645 3.514870137 4.879196601 0.027182268 CHIT1 1118 -0.875194828 2.642251561 5.095912037 0.0239823 CHMP4B 128866 -0.502210229 5.626189444 4.716386581 0.029876462 CHPT1 56994 -0.5648774 6.477445799 4.221086576 0.039924586 CISD2 493856 -0.905533407 6.40493859 12.04996112 0.000517935 CLEC4D 338339 -0.661843044 5.686700151 5.437060661 0.019713817 CLIC2 1193 -0.903715363 4.68207407 13.1856693 0.000282098 CLLU1 574028 -0.685896477 1.463291604 9.922837419 0.001632405 CMAS 55907 -0.916911977 4.950486549 15.83534572 6.91E-05 CNPPD1 27013 -0.687998586 6.062409138 6.433597811 0.011198152 COBLL1 22837 -0.618744405 3.550462025 9.037944749 0.002644328 CPEB4 80315 -0.549395543 7.798554086 7.614872522 0.005788885 CPM 1368 -0.466043469 2.792663291 4.779289491 0.028804003 CR1L 1379 -0.702628084 4.544088466 6.885911234 0.008687777 CREG1 8804 -0.723741306 6.364316157 6.712419724 0.009574372 CRISP3 10321 -1.497588179 4.309867419 8.991456276 0.002712448 CTNNAL1 8727 -0.817794839 4.030312425 6.537675851 0.010561324 CTSB 1508 -0.663977073 8.09733982 5.019916362 0.025057379 CUL4A 8451 -0.730985432 6.53925285 13.06019206 0.000301639 CYBRD1 79901 -0.467739253 5.324091802 4.006444207 0.045326649 CYSTM1 84418 -0.610814028 5.185166381 5.779183618 0.016217072 DCAF10 79269 -0.448804702 5.78327716 5.987631037 0.014406537 DCAF12 25853 -1.232265281 10.84837685 7.305154787 0.006875707 DCAF6 55827 -0.767255584 6.618338274 12.27032593 0.000460218 DCK 1633 -0.414406375 5.836733782 5.080983929 0.024189639 DCTN4 51164 -0.410514972 6.119282061 4.491387589 0.034066016 DCUN1D1 54165 -0.704665993 8.249193328 8.99938843 0.0027007 DDB1 1642 -0.505901622 6.88312054 5.042920718 0.024726766 DENND4A 10260 -0.441193266 7.993853375 3.89884084 0.048319435 DHCR24 1718 -0.629238667 1.967846391 6.989162742 0.00820047 DHX40 79665 -0.450250388 5.869862086 4.704544729 0.030082969 DLEU2L 79469 -0.440040039 1.118199242 4.088782679 0.043168722 DMTN 2039 -1.035811729 8.060960835 7.171551385 0.007406869 DNA2 1763 -0.464065503 4.442470953 4.947975748 0.026121236 DNAH11 8701 -0.766184243 1.129797919 5.450276637 0.019565228 DNAJA4 55466 -0.785865347 5.577638825 7.092172398 0.007742134 DNAJB4 11080 -0.47673213 4.215112351 4.552599853 0.032868802 DNAJC6 9829 -0.754793241 6.278704181 15.03201477 0.000105703 DPCD 25911 -0.81048777 2.4499025 4.155482555 0.041499947 DPM2 8818 -0.896296273 5.745498365 5.032971033 0.024869202 DPY19L1P1 100129460 -0.464412565 4.306339844 5.05762783 0.024517775 DTL 51514 -0.888799738 2.305271828 9.724119472 0.001818654 DYRK3 8444 -0.874613946 2.430150457 5.262392572 0.021791042 E2F2 1870 -0.890171242 6.423155479 5.976121862 0.014500854 ECSIT 51295 -0.6285537 3.55449984 4.369458241 0.036588623 ECT2 1894 -0.408058072 3.934908283 3.964262032 0.046475889 EIF1 10209 -0.508800483 7.75783744 5.043183755 0.024723012 EIF1B 10289 -0.760872075 6.560338662 10.12231778 0.001464847 EIF2AK1 27102 -0.980569605 8.211829528 8.997620096 0.002703314 EIF5AL1 143244 -0.441258095 3.580737676 5.118888469 0.023666771 ELK2AP 2003 -1.124080438 3.314296943 14.18691648 0.000165517 ENTPD5 957 -0.644799188 3.733873008 4.47042213 0.03448647 EPB41 2035 -1.181070657 10.99624104 8.435640234 0.003679373 EPB42 2038 -1.012778257 6.452870276 4.016594217 0.045054609 ERLIN1 10613 -0.744407731 4.546517239 6.872862428 0.008751437 FAHD1 81889 -0.548715774 2.673121625 3.858543174 0.049493285 FAM104A 84923 -0.855097473 6.700956931 6.201978734 0.012760757 FAM117A 81558 -0.901494633 6.728057776 9.785682394 0.001758759 FAM20B 9917 -0.5725729 5.654339961 6.393764411 0.011452191 FAM210B 116151 -1.036544234 8.750997384 6.36412428 0.011645055 FAM214B 80256 -0.451802205 6.270815545 4.7131056 0.02993353 FAM228B 375190 -0.485958108 3.354967198 5.964261191 0.014598716 FAM46C 54855 -1.212532926 11.65857725 7.311214096 0.006852561 FAXDC2 10826 -0.73926597 6.746685815 5.378875143 0.020382015 FBXL4 26235 -0.432030636 5.770079701 5.562196195 0.018352377 FBXO7 25793 -0.830927673 10.61279184 5.179795261 0.022851016 FBXO9 26268 -0.774347587 7.047177211 5.090575349 0.024056209 FCAR 2204 -0.564057436 5.602807137 5.276340105 0.021617142 FCRL1 115350 -0.59024135 4.793238037 7.986894486 0.004711717 FCRL5 83416 -0.467099065 3.203892952 5.976772303 0.014495507 FCRLA 84824 -0.671427455 2.443977061 9.700638388 0.00184204 FECH 2235 -1.149386291 9.615502654 9.177966898 0.00244946 FEM1A 55527 -0.633529015 5.141550359 7.650603131 0.005675334 FGFR1OP2 26127 -0.493649074 7.066188195 5.08483614 0.024135957 FKBP5 2289 -0.872386286 7.399986442 6.325844502 0.011899081 FLJ23867 200058 -0.45498235 1.659105646 3.876627353 0.048962821 FOXO3 2309 -1.172934444 9.810786121 10.08712544 0.001493088 FOXO3B 2310 -1.127362399 7.909052368 13.72037475 0.000212141 FURIN 5045 -0.624144938 6.991290032 7.935032497 0.004848676 FZD5 7855 -0.874623795 1.754739763 11.07581089 0.000874612 GABARAPL2 11345 -0.887395433 8.215869363 7.454837856 0.006326618 GALNT5 11227 -0.658974181 2.537873021 6.362335564 0.0116568 GAS2L3 283431 -0.631123994 1.081317318 6.488580392 0.010856964 GATA1 2623 -0.743718874 4.429216402 4.946052319 0.026150315 GATSL2 389523 -0.877297564 1.892984653 11.69341096 0.000627218 GATSL2 729438 -0.858696036 1.938902135 11.29767294 0.000776043 GCLC 2729 -0.997935904 6.531400729 13.4232242 0.000248528 GCLM 2730 -0.490860615 4.34196453 4.90963564 0.026707274 GDE1 51573 -0.629142233 6.535880315 7.895557828 0.004955635 GID4 79018 -0.649725198 4.717727867 5.870964065 0.01539262 GLRX5 51218 -1.211554708 8.169376643 11.16501217 0.000833544 GLUL 2752 -0.653582603 9.489379982 4.278285274 0.038602273 GMPR 2766 -1.228896439 6.519035099 8.490877404 0.003569316 GPR141 353345 -0.514998285 4.076974248 4.972311542 0.025756204 GPR146 115330 -1.26474505 4.473191379 9.821011091 0.001725295 GRINA 2907 -0.672205473 6.824727137 6.604859336 0.010170084 GSPT1 2935 -1.231489632 9.216337819 11.42820385 0.000723376 GUCD1 83606 -0.894458414 7.899031121 5.736903958 0.01661205 GUCY2C 2984 -0.503076562 2.647004556 4.616728714 0.031661566 GUK1 2987 -0.990471696 8.089988789 5.750605739 0.016482972 H1F0 3005 -0.826043529 4.80428436 6.415364874 0.011313708 HAGH 3029 -0.968347259 6.700514872 6.843318354 0.008897341 HBM 3042 -1.091650315 4.770986183 6.686366858 0.0097153 HECTD4 283450 -0.493740135 7.200523801 5.888482648 0.015240226 HEMGN 55363 -0.641934764 9.30260572 5.24507857 0.022008934 HIPK1 204851 -0.581013137 8.6009859 5.507660789 0.018933353 HIST3H2BB 128312 -0.989452375 4.147090858 9.064144086 0.002606705 HK1 3098 -0.54007765 7.368314454 4.166017983 0.041242622 HPS1 3257 -0.509961427 6.592146751 3.924581795 0.047585024 IFIT1B 439996 -0.964238025 6.481386186 10.27699437 0.001346992 IFRD2 7866 -0.441472341 2.250508821 4.474977977 0.034394646 IFT52 51098 -0.42893095 3.577234304 4.210510822 0.040174237 IGF2BP2 10644 -0.826956967 5.94207288 6.990602611 0.008193876 IGLL5 100423062 -0.966327895 3.501285785 16.11088025 5.97E-05 IL18R1 8809 -0.847408592 6.098216422 4.61473964 0.031698307 IL18RAP 8807 -0.576449672 7.321694463 5.106392119 0.023837842 IL1R1 3554 -0.581497071 4.831587502 4.986440321 0.02554671 INPP5K 51763 -0.440916896 5.189848339 4.400847357 0.035921078 INSR 3643 -0.43515284 3.882368037 3.937389249 0.047224013 IRAK3 11213 -0.690871022 7.837022431 6.835898232 0.008934376 ISCA1 81689 -0.99622261 6.908582234 13.4557861 0.000244252 ISCU 23479 -0.613055168 6.407396674 6.485774717 0.010874114 ISPD 729920 -0.654333765 4.053299536 12.60780583 0.000384139 JAZF1 221895 -0.770473977 7.39871138 10.09538942 0.001486407 JCHAIN 3512 -1.177497678 6.29372114 18.44272861 1.75E-05 KANK2 25959 -1.225814566 4.034693344 8.544822618 0.003465064 KAT2B 8850 -0.884047186 8.299701417 11.05380194 0.000885055 KDM7A 80853 -0.444318263 8.094372605 4.737760576 0.029507457 KIAA0430 9665 -0.715784956 8.687326888 8.915666662 0.002827346 KIAA1586 57691 -0.417872213 5.184609932 6.018254462 0.014158644 KIAA1715 80856 -0.525182902 5.97475299 5.730950121 0.016668462 KIF11 3832 -0.66019763 3.563076678 5.018086197 0.025083878 KIF14 9928 -0.567511506 4.976652194 4.7513156 0.029275904 KIF15 56992 -0.601769922 4.298407577 5.275022795 0.021633505 KIF18A 81930 -0.603318531 3.503394476 6.121759966 0.013352779 KLC3 147700 -0.891663896 2.148313403 10.47751254 0.001208363 KLHL14 57565 -0.624294811 1.317343698 7.657612321 0.005653327 KLHL8 57563 -0.485688608 5.473220178 4.973602927 0.025736982 KRT1 3848 -0.649680375 6.897396639 4.073058723 0.043572307 LGALS3 3958 -0.976087052 6.441296885 6.680188118 0.009749034 LILRA5 353514 -0.443918969 6.930574451 4.279347944 0.038578145 LNX2 222484 -0.50820492 4.07928511 6.762368498 0.009310011 LOC100131257 100131257 -0.567834836 1.404036368 4.348743547 0.03703626 LRRC8A 56262 -0.475350948 4.13060201 6.166975803 0.013015692 LTF 4057 -1.776449055 8.00545401 9.066354318 0.002603556 MAF1 84232 -0.689420469 6.167132077 5.48905934 0.019135836 MANSC1 54682 -0.520671758 4.665181536 4.377411291 0.036418268 MAP1LC3B 81631 -0.618461954 6.473055318 8.898671083 0.002853783 MAP1LC3B2 643246 -0.677890175 4.584564467 8.660585427 0.003251668 MAP2K3 5606 -0.913939866 8.374054084 10.94087806 0.000940656 MAP2K7 5609 -0.495919673 4.684746478 5.13178874 0.023491506 MAP4K5 11183 -0.411580037 6.12159867 4.924875139 0.026472715 MARK3 4140 -0.609441439 7.302863565 8.25028704 0.004074556 MBNL3 55796 -0.947874518 10.71070093 7.330897984 0.006777918 MBOAT2 129642 -0.46547549 7.7853561 5.520458666 0.01879533 MCEMP1 199675 -0.748880447 5.023795143 6.561338108 0.010421797 MCM10 55388 -0.537528774 2.31954968 4.351013029 0.036986939 MCOLN1 57192 -0.716532985 3.764794651 8.76226377 0.003075271 MELK 9833 -0.654178988 2.495299536 7.007028426 0.008119033 METTL9 51108 -0.530536235 6.928834567 4.187647812 0.040719558 MFHAS1 9258 -0.431792276 4.680671405 4.83793106 0.027840277 MFSD13A 79847 -0.435810429 2.504418909 3.85279481 0.049663171 MICAL2 9645 -0.84080931 8.139103999 9.559331501 0.001989355 MICALCL 84953 -0.908730398 3.950910562 12.90776572 0.000327222 MINPP1 9562 -0.466228852 4.196019759 5.955980245 0.014667445 MKI67 4288 -0.904590368 4.94745544 7.002257114 0.008140701 MKRN1 23608 -1.090739819 11.02384404 6.532896243 0.010589739 MKRN9P 400058 -1.149723834 5.556684138 14.67341033 0.000127837 MLC1 23209 -0.730620475 3.272073105 5.316401994 0.021125588 MOSPD1 56180 -0.857171727 4.505125362 14.00723588 0.000182108 MPO 4353 -1.232843533 4.327181227 3.851029035 0.04971548 MPP1 4354 -1.060541755 9.000054829 7.727418798 0.005438845 MPP6 51678 -0.574795169 4.739718811 8.935645557 0.002796586 MRC2 9902 -1.068735346 4.326271571 4.843707085 0.027747186 MS4A1 931 -0.421722508 5.355369134 5.467004163 0.019378817 MS4A4A 51338 -0.91135517 2.036094796 12.57509119 0.000390922 MXI1 4601 -1.131688004 9.071778189 10.72511571 0.001056911 MYBL2 4605 -0.863319665 1.633300653 5.773336915 0.01627111 MYL4 4635 -0.903244785 5.399525129 5.438098012 0.019702112 NCAPG 64151 -0.700188942 3.227047633 9.548954726 0.002000633 NCAPH 23397 -0.73454644 2.270915956 5.17969961 0.022852274 NCR1 9437 -0.486916418 2.767209708 6.644246861 0.009947652 NEDD4L 23327 -0.787034356 3.925175293 5.467422222 0.019374182 NEIL3 55247 -0.45393154 5.990315236 3.854872459 0.049601698 NFIA 4774 -0.62553284 4.474008976 8.16778355 0.004264098 NFIX 4784 -1.058441307 6.025680408 9.376477305 0.002197875 NLRC4 58484 -0.562431538 6.050534905 5.139570778 0.02338643 NME8 51314 -0.737292818 2.651313027 12.3029423 0.000452245 NPL 80896 -0.426407019 6.773092027 4.786740688 0.028679647 NPRL3 8131 -0.739205323 5.980295442 8.452511868 0.003645396 NSUN3 63899 -0.762251604 6.858670315 14.44653337 0.000144195 NUDT4 11163 -0.733009764 7.42214709 7.421990737 0.006443149 ODC1 4953 -0.530853454 7.059640021 4.881551222 0.027145213 OLFM4 10562 -1.535484334 7.003237807 4.129159493 0.042150281 OPTN 10133 -0.769292413 8.02819571 5.252948333 0.021909617 OSBP2 23762 -0.945021968 6.619931528 4.417298131 0.035576327 OSBPL10 114884 -0.63566949 2.359914493 8.022108671 0.004620974 PA2G4 5036 -0.561137057 4.902954239 5.173527071 0.022933607 PARPBP 55010 -0.541041482 2.753201508 5.166408153 0.023027782 PBX1 5087 -0.462732622 4.707391581 4.475559746 0.034382938 PCDH9 5101 -0.473902911 2.166875856 5.262697113 0.02178723 PCMTD2 55251 -0.458907247 6.710223488 5.599627463 0.017964297 PDCD10 11235 -0.519093031 6.481102585 6.480450599 0.010906733 PER1 5187 -0.614633441 3.342673033 5.224779709 0.022267267 PFKFB3 5209 -0.471255743 6.658621019 5.500732489 0.01900851 PGM2L1 283209 -0.892033454 5.309877306 18.63135938 1.59E-05 PHLPP2 23035 -0.495943847 4.897341997 5.085867135 0.024121611 PIM1 5292 -0.760334511 8.755942488 5.000924238 0.025333787 PINK1 65018 -0.803285294 6.671062055 5.980356015 0.014466082 PIP4K2A 5305 -0.923901904 9.762503978 6.642690346 0.009956347 PIP5K1B 8395 -0.557638959 4.699246148 6.379016364 0.011547741 PITHD1 57095 -1.088191698 7.643380527 9.716635449 0.001826075 PLBD1 79887 -0.55205985 7.465058451 5.655331424 0.017402386 PLBD2 196463 -0.430471756 2.16682911 3.880770497 0.048842138 PLCL2 23228 -0.566380485 7.38991362 5.485731684 0.019172294 PLSCR1 5359 -0.460138119 6.334063297 4.776451038 0.028851523 PNPLA2 57104 -0.596280406 4.917798777 6.320164861 0.011937253 POC1B 282809 -0.689481961 5.957983572 8.550741004 0.003453816 POLE2 5427 -0.555419163 3.552204831 9.642848266 0.001900902 POLL 27343 -0.676567141 5.542390473 5.328676402 0.02097731 POTEI 653269 -0.482436394 2.79410451 4.530280945 0.03330015 POU2AF1 5450 -0.479447767 2.171554601 4.786374628 0.028685743 PPM1A 5494 -0.742751848 8.722857483 7.537431949 0.006043011 PPP1CB 5500 -0.521618234 8.378529767 5.021490402 0.025034612 PPP2R5B 5526 -0.790174829 4.359592934 6.485547622 0.010875503 PPP3R1 5534 -0.734842061 8.066625678 10.00843674 0.001558247 PPP4R2 151987 -0.510808125 6.118259007 4.326511222 0.037523081 PRDX2 7001 -0.786725413 5.612599047 4.213874488 0.040094657 PRDX5 25824 -0.647470668 6.185703832 4.584596587 0.032260564 PRELID2 153768 -0.474107915 1.557384644 4.248933858 0.039274979 PSAT1 29968 -0.751373687 1.120500036 6.28705631 0.012162288 PSME4 23198 -0.665282596 7.430322919 9.607654133 0.00193768 PSMF1 9491 -0.866673258 7.471288116 7.330835349 0.006778154 PTGES3 10728 -0.621182935 6.850419051 9.364180903 0.002212669 R3HDM4 91300 -0.727020223 8.747865936 5.619311939 0.017763621 RAB2B 84932 -0.799015108 7.78147508 7.582168609 0.005894848 RAB3IP 117177 -0.400736642 4.841704368 4.717253008 0.029861411 RAB5B 5869 -0.458519529 6.461409261 5.22949379 0.022206995 RAB6A 5870 -0.475784296 6.894547334 4.351826001 0.036969288 RALBP1 10928 -0.439772529 7.068461704 3.921235666 0.047679823 RANBP10 57610 -0.867821075 6.186395473 9.560733881 0.001987836 RANBP9 10048 -0.410110704 6.340999484 3.964021771 0.046482523 RASGRP3 25780 -0.516046655 4.581361431 4.48189681 0.034255683 RBBP8 5932 -0.546460933 4.083800918 7.251137355 0.007085612 RBM38 55544 -1.05673245 8.692831475 7.800970234 0.005221819 RCL1 10171 -0.470250881 4.128938156 5.408465051 0.020039329 RHBDD1 84236 -0.477163676 6.039054757 4.377263438 0.036421428 RILP 83547 -0.833152453 4.232433079 6.524268498 0.010641231 RIOK3 8780 -1.245974845 10.05689142 11.67784725 0.000632487 RMND5A 64795 -0.479612153 8.119798979 3.894554245 0.048442893 RNF10 9921 -1.110397819 9.188059069 8.689292391 0.003200849 RNF11 26994 -0.862165266 9.385050565 7.88407404 0.004987201 RNF123 63891 -0.626288709 5.753271231 7.752813696 0.005362892 RNF14 9604 -1.009161821 6.907017721 11.20218831 0.000817009 RNF187 149603 -0.652342218 5.566695924 4.187912546 0.040713199 RPIA 22934 -1.039567407 7.404847161 10.25041066 0.001366542 RSC1A1 6248 -0.449990047 2.847520076 5.115921336 0.023707275 RUNDC3A 10900 -1.349128287 4.541052534 8.838725646 0.00294905 SAP30 8819 -0.789977021 2.684549361 6.730588816 0.009477331 SBF2-AS1 283104 -0.591720224 2.034148331 6.224984828 0.012595999 SCD 6319 -0.694357876 2.709693327 4.013444636 0.04513884 SCN9A 6335 -0.652187007 2.521063174 8.428173105 0.003694514 SEC62 7095 -0.80718157 8.104357705 10.7815967 0.001025142 SELENBP1 8991 -1.376488902 7.815332363 7.286850916 0.006946113 SELK 58515 -0.805249359 5.62169508 7.343108738 0.006732032 SESN3 143686 -0.735470806 9.038057109 6.87017836 0.00876459 SGMS2 166929 -0.512423736 4.438996483 5.149098069 0.023258451 SHARPIN 81858 -0.562426429 4.799374471 5.133964979 0.023462072 SIAH2 6478 -1.05510011 8.06596087 8.602807049 0.003356453 SKA3 221150 -0.466544013 4.591786939 5.743778326 0.01654716 SKP1 6500 -0.540072483 7.542157624 5.033661556 0.024859289 SKP1P2 728622 -0.669543357 3.204478663 7.616135332 0.005784833 SLC14A1 6563 -1.011581586 6.641136176 7.102093454 0.007699397 SLC18B1 116843 -0.466703094 4.749371919 5.392208506 0.020226855 SLC1A5 6510 -0.945248724 5.662011166 7.346532217 0.006719224 SLC22A16 85413 -0.699474563 1.983612643 5.134095177 0.023460313 SLC25A37 51312 -1.054275375 11.36372131 6.297160646 0.012093152 SLC25A39 51629 -1.195997521 9.828144514 5.954397719 0.014680617 SLC36A4 120103 -0.432377534 3.606806317 4.052188612 0.044114117 SLC38A5 92745 -0.734178137 4.603131668 7.611687431 0.005799119 SLC4A1 6521 -1.314171816 10.00830601 5.811659434 0.015920265 SLC6A8 6535 -1.014258114 6.558071328 5.573928019 0.018229821 SLC6A9 6536 -1.079566804 2.590327706 6.746689785 0.009392178 SLC7A1 6541 -0.500276105 3.955759652 5.789278374 0.016124207 SLC7A5 8140 -0.660434342 4.517169372 5.485923151 0.019170194 SLFN14 342618 -0.420433749 4.525583873 4.110356737 0.042621371 SMIM5 643008 -0.654364499 4.039908154 4.291126125 0.038311782 SMPDL3A 10924 -0.530691076 2.604291274 7.114448891 0.007646511 SNCA 6622 -0.99133506 11.02253699 5.714183223 0.016828392 SNX3 8724 -0.859032066 7.854118199 7.364189053 0.00665356 SORT1 6272 -0.478706081 6.180363878 4.160261032 0.041383026 SOX6 55553 -0.661248827 6.704718451 7.150301282 0.007495139 SPECC1 92521 -0.688168069 8.075072223 5.445649517 0.01961712 SPIB 6689 -0.477726013 2.280017619 5.088691349 0.024082358 SPRY3 10251 -0.400945499 4.094974114 4.948835982 0.026108241 SPTA1 6708 -0.749269242 5.333562709 4.187885596 0.040713846 SPTB 6710 -0.997605003 7.461437953 7.931316189 0.004858644 SRGAP2 23380 -0.445169945 4.183454578 6.033986831 0.014033003 SRRD 402055 -0.899878988 4.904605959 5.857968485 0.015506682 SRXN1 140809 -0.706595692 6.210601295 7.285047386 0.00695309 SSBP3 23648 -0.455432939 4.254326921 5.28348268 0.021528644 ST13 6767 -0.656622587 7.395062793 5.84596141 0.015612841 ST13P4 145165 -0.599170432 5.247409666 4.352495655 0.036954755 ST6GALNAC4 27090 -0.816726481 5.214154134 4.195017116 0.040542944 STAU1 6780 -0.598498113 6.436789228 8.572744997 0.003412323 STEAP3 55240 -0.714646381 1.566653885 10.0366474 0.001534562 STIL 6491 -0.53570637 5.674004835 3.895193739 0.048424454 STK11 6794 -0.575313999 5.128239322 5.452120745 0.019544587 STOM 2040 -0.836261893 8.419701738 5.014326503 0.025138406 STOML2 30968 -0.41575027 3.912594108 4.305965381 0.037978934 STRADB 55437 -1.191576351 8.964700838 7.729926627 0.005431296 STS 412 -0.498348442 3.221244126 5.848951616 0.015586334 SUDS3 64426 -0.438900234 6.190154968 4.97851094 0.025664064 SWT1 54823 -0.544399897 6.801653689 9.310307078 0.002278683 TANGO2 128989 -0.516806378 6.270550739 4.04946998 0.044185216 TANK 10010 -0.414640022 7.062239683 4.453339658 0.034833063 TARS 6897 -0.428269983 5.015963725 4.089213146 0.043157729 TBC1D22B 55633 -0.761083572 5.226987212 9.110143142 0.00254196 TBC1D31 93594 -0.446795002 5.599193782 5.718118203 0.016790717 TBC1D8 11138 -0.638038209 4.739654783 8.65750844 0.003257164 TBCEL 219899 -0.843811265 7.358916328 13.10962685 0.000293782 TCF3 6929 -0.580633552 4.79323499 6.078038198 0.013687269 TCL1A 8115 -0.575858752 3.122112408 7.13096768 0.007576383 TCP11L2 255394 -0.893676265 8.570896917 9.847275709 0.001700835 TENM1 10178 -0.584701556 4.586764877 5.886851239 0.015254352 TERC 7012 -0.603219871 1.773829626 4.342926062 0.037163003 TESC 54997 -0.743832956 6.23356197 4.058152147 0.043958577 TFDP1 7027 -0.615372929 7.103703188 4.527099378 0.033362119 TFDP2 7029 -0.476693705 6.085691786 5.656427791 0.01739151 TFR2 7036 -0.848020977 1.478132197 7.94774762 0.004814726 TFRC 7037 -0.594121048 6.990077416 4.422451661 0.03546904 TGM2 7052 -1.119761565 3.623673878 5.858310329 0.01550367 TIPIN 54962 -0.461152595 2.200143743 4.469473833 0.034505616 TLE1 7088 -0.45817981 1.520771083 4.830850301 0.02795484 TMEM200B 399474 -1.23506873 3.675638722 13.56809164 0.000230063 TMEM56 148534 -0.832316799 5.140279769 10.06617848 0.001510159 TMEM63B 55362 -1.074582643 5.908412645 9.814043214 0.001731843 TMOD1 7111 -1.005347134 5.167364145 8.336559807 0.00388551 TMTC1 83857 -0.476108694 4.021970277 6.476235589 0.010932628 TNS1 7145 -1.402159871 8.373540184 10.13757213 0.001452774 TNXB 7148 -0.497826158 2.812913861 5.802601347 0.016002482 TOP1 7150 -0.489773626 7.073006694 6.046403652 0.013934651 TOP1P1 7151 -0.465330715 2.425949508 4.764023454 0.029060541 TPRG1L 127262 -0.407488203 5.128776612 4.347896938 0.037054677 TRAK2 66008 -0.91399359 8.419501277 9.056740626 0.002617281 TRIM23 373 -0.643256083 6.314912541 7.615818552 0.005785849 TRIM58 25893 -1.374029823 9.259021143 13.54214208 0.000233266 TRIP12 9320 -0.4972338 8.71248195 4.26073095 0.039003135 TRIQK 286144 -0.627314028 4.709233728 6.145511066 0.013174609 TROAP 10024 -0.867976694 2.517072614 5.555517022 0.018422531 TRPM2 7226 -0.493553974 3.611021379 5.872682245 0.015377605 TSPAN5 10098 -1.236691538 7.169848103 16.30871543 5.38E-05 TSTA3 7264 -0.873380722 4.818064631 8.953279046 0.00276972 TTK 7272 -0.955057253 1.433042035 6.713544488 0.009568335 TUBB2A 7280 -1.16512926 5.130814661 7.424511536 0.006434129 UBAP1 51271 -0.471958688 6.421971152 4.07198222 0.043600082 UBE2B 7320 -0.669887527 7.322801103 11.45219926 0.000714094 UBE2F 140739 -0.596836392 5.23949612 6.406063546 0.011373128 UBE2H 7328 -0.970775595 8.116713706 12.17007799 0.000485623 UBE2O 63893 -1.284710502 6.79351989 12.97073254 0.000316398 UBQLN1 29979 -0.436593871 7.037514455 5.233390911 0.022157295 UBXN6 80700 -0.954757813 8.058540546 6.319369075 0.011942611 UGCG 7357 -0.661366885 4.718483059 5.026154917 0.024967269 USP12 219333 -0.854262995 8.030784522 13.66681813 0.000218277 USP6NL 9712 -0.409121261 3.944236236 4.394182679 0.036061741 VRK1 7443 -0.575437252 6.351342745 4.506762396 0.033761088 VTI1B 10490 -0.668572093 4.562145833 5.748315331 0.016504477 WASF2 10163 -0.618732061 7.637612183 6.932045749 0.008466479 WBP2 23558 -0.513157683 6.795058483 4.303401862 0.038036217 WDR26 80232 -0.656156275 9.038006597 6.120908978 0.013359209 WDR45 11152 -0.470743197 5.464203281 3.958021868 0.046648491 WIPI2 26100 -0.442471436 5.932145867 5.273285204 0.021655108 WNK1 65125 -0.911390919 9.665890563 8.551329157 0.0034527 WTH3DI 150786 -0.520600225 2.270804784 5.417982216 0.01993038 XPO7 23039 -0.507503667 7.322391059 4.987829543 0.025526207 YBX3 8531 -0.913814998 9.071960929 5.32933669 0.020969364 YBX3P1 440359 -0.88495348 5.366867063 7.125291257 0.007600407 YIPF6 286451 -0.684317457 6.199404697 10.19704667 0.001406658 YOD1 55432 -1.141739702 9.802198152 11.1165384 0.000855613 YY1AP1 55249 -0.449906672 6.826682979 5.354761715 0.020665758 ZBTB16 7704 -1.04921903 3.559475204 9.392939466 0.002178227 ZER1 10444 -0.854707383 6.941609538 11.38015573 0.000742329 ZFAND4 93550 -0.661662569 4.985473707 10.2283601 0.001382976 ZRANB1 54764 -0.6832093 7.073864214 8.4893377 0.003572338 ZWILCH 55055 -0.431961641 3.66471018 4.380426083 0.036353909 Table S7 AZA, genes over-expressed on treatment compared to pre-treatment.

Gene Symbol Entrez ID logFC logCPM LR PValue ABCA1 19 0.456568523 6.896181055 5.055839691 0.024543087 ABCD2 225 0.579816357 4.571286202 4.290859739 0.038317785 ABCG1 9619 0.420767251 4.760767909 5.120228988 0.023648496 ACACB 32 0.661803401 3.588071877 7.409235002 0.006488991 ACCS 84680 0.477234813 3.323847515 4.528169823 0.033341256 ACSF2 80221 0.626707123 2.678694151 6.617178185 0.010099973 ADGRE4P 326342 1.195748443 5.814635455 19.89238322 8.19E-06 ADORA3 140 0.469430472 3.035863072 3.88901979 0.048602782 ADTRP 84830 0.50987251 2.4858801 6.626686251 0.010046199 AEN 64782 0.520807369 3.724155243 6.49883141 0.010794542 AGAP7P 653268 0.498799737 4.308465213 6.354004918 0.011711661 ANO9 338440 0.770901734 3.578361747 8.205770905 0.004175736 AOC3 8639 0.618399169 2.143224078 5.388377867 0.020271307 APBB1 322 0.656313681 4.017014128 8.060531718 0.004523991 AQP3 360 0.52634529 4.509418223 5.368051999 0.020508869 ARHGAP10 79658 0.412664499 3.063577013 4.480503766 0.034283614 ASPSCR1 79058 0.430169399 1.948860178 4.397606105 0.035989415 ASRGL1 80150 0.47571403 2.519474528 5.881257067 0.015302892 ATP8B2 57198 0.52420364 6.368019147 4.731114707 0.029621681 BBC3 27113 0.436408621 2.473538705 4.967585424 0.025826678 BCDIN3D 144233 0.615661394 1.991113902 6.940011868 0.008428855 BCL2 596 0.449709958 6.3202777 5.663530082 0.017321226 BHLHE40 8553 0.447492051 4.488831726 3.918124463 0.047768144 C10orf128 170371 0.568136376 3.948428878 9.34302984 0.002238352 C22orf29 79680 0.408392176 3.850138987 4.430447496 0.035303251 C5orf63 401207 0.541743663 2.326110798 6.114306219 0.013409204 CACNA1D 776 0.619999373 1.83958929 6.102726208 0.01349735 CACNB4 785 0.499197946 2.162351623 4.268806227 0.038818193 CAMK1 8536 0.603049913 3.64420387 5.026506423 0.024962202 CARMIL2 146206 0.520050674 3.88198322 4.448326427 0.034935468 CCDC18-AS1 100131564 0.454566062 4.616470917 5.042764687 0.024728993 CD101 9398 0.540197222 4.202097307 5.087206354 0.024102989 CD200R1 131450 0.450718889 3.870195208 6.217581519 0.012648778 CD3D 915 0.667616051 5.756006256 5.925319774 0.01492483 CD52 1043 0.453891602 6.901895536 4.825441909 0.028042676 CD6 923 0.598997247 5.181742616 4.848112671 0.027676399 CD7 924 0.531242719 3.81502913 6.33675484 0.011826105 CD8B 926 0.641454409 4.367051796 5.271382694 0.021678787 CDKN1A 1026 0.487804944 4.108135573 4.670521384 0.030684611 CISH 1154 0.518538908 4.350513303 5.715249285 0.016818176 CLC 1178 1.12810691 7.580877414 21.14649115 4.25E-06 CNTNAP1 8506 0.443930009 2.074140577 4.220077261 0.039948342 COL9A2 1298 0.427740259 2.535130862 4.034267633 0.044585023 CROCC 9696 0.525924585 3.09052513 6.624435029 0.010058904 CROCCP3 114819 0.548498042 3.422138194 4.600237286 0.031967531 CSF1 1435 0.632348138 3.228476683 9.360977337 0.002216539 CYP4F12 66002 0.7016982 2.812140934 8.980720354 0.002728431 DDB2 1643 0.462587604 3.753127973 5.928152343 0.014900857 DEPDC5 9681 0.433239008 4.312451373 4.30487522 0.038003283 DFFB 1677 0.443982454 2.618425429 4.206149907 0.040277657 DPH7 92715 0.416121044 2.832607278 4.5092948 0.033711137 EEF2K 29904 0.562362787 4.410241017 8.505938165 0.003539894 ENGASE 64772 0.430736642 4.211815241 4.063197388 0.043827439 ENO2 2026 0.532088204 3.243259704 6.261535801 0.012338719 EPN2 22905 0.878278765 3.113504429 14.42717019 0.000145685 ESYT1 23344 0.569546879 6.97426946 4.930850322 0.026381333 EVL 51466 0.615003668 7.078080544 4.845506165 0.027718256 FBXO44 93611 0.481864948 2.663336909 5.466739691 0.01938175 FLAD1 80308 0.407296618 3.426483155 4.757000299 0.029179359 FLNB 2317 0.489536877 5.553573085 4.015634312 0.045080263 FLT3LG 2323 0.531003917 3.385883729 4.29409254 0.038245001 GALT 2592 0.489955999 4.330551439 4.76026092 0.029124133 GOLGA2P10 80154 0.709177876 2.198262979 8.456372383 0.003637667 GOLGA6L10 647042 0.439910487 3.079098328 3.931940088 0.047377258 GOLGA6L9 440295 0.624118824 4.169182462 6.471444392 0.01096214 GOLGA8A 23015 0.507412411 5.796735634 5.425502168 0.019844728 GOLGA8B 440270 0.50848119 6.409874038 5.661710753 0.017339202 GPR183 1880 0.482258033 5.575426358 4.341984524 0.037183559 GPR34 2857 0.575855435 3.315925939 8.392303207 0.003768131 GPRASP1 9737 0.543856086 4.289417681 5.304887205 0.021265677 GRAP 10750 0.431210789 4.231501686 4.166773805 0.041224226 GSDMB 55876 0.635729926 4.168088608 7.79477609 0.00523975 GSTM4 2948 0.420972238 1.707159261 3.859835428 0.049455179 GUSBP4 375513 0.515570183 3.042648935 4.09972047 0.042890304 HAPLN3 145864 0.634332705 3.433505697 5.686413873 0.017096758 HEMK1 51409 0.41037871 3.952681944 3.921123342 0.047683008 ICOS 29851 0.641313448 3.85136959 4.923929105 0.026487213 IKZF2 22807 0.705787701 5.762270013 4.529109082 0.033322961 IL11RA 3590 0.558445135 4.343735244 4.15039598 0.041624789 IL1RL1 9173 0.701404095 3.476961577 13.25848354 0.000271349 IL32 9235 0.563296299 5.824495452 4.208101879 0.040231331 INPP4B 8821 0.543833754 5.689337316 4.454615339 0.034807055 ITM2A 9452 0.468148287 4.613502206 5.549657483 0.018484304 KIFC2 90990 0.641409028 2.343418861 9.183302451 0.002442329 LCK 3932 0.552845078 6.309108059 4.555248985 0.032817992 LDHB 3945 0.400129573 7.205655098 3.941588618 0.047106273 LFNG 3955 0.595076387 6.395838132 5.490354622 0.019121664 LGALS12 85329 0.44681681 3.826265832 4.525510834 0.033393105 LINC01003 100128822 0.486410815 1.733544438 5.660580287 0.017350382 LMO7 4008 0.401009966 3.333967116 3.84528348 0.049886088 LOC100506123 100506123 0.66253836 4.551539863 6.497058392 0.010805312 LOC100507373 100507373 0.444697897 2.083998072 4.183865803 0.040810511 LOC150776 150776 0.548890062 3.736529166 6.318315251 0.011949711 LOC646471 646471 0.748167029 2.358126138 13.76244429 0.000207442 LOC728392 728392 0.433129061 3.772612063 4.477999409 0.034333889 LPAR6 10161 0.426924047 5.739476295 4.033352584 0.044609209 LSR 51599 0.438317101 2.179940675 4.56955838 0.032544954 LTBP3 4054 0.724735708 3.556429662 7.188552974 0.007337012 MAGEF1 64110 0.505486908 1.986282237 6.685036577 0.009722553 MUM1 84939 0.481784612 2.761286714 4.153893194 0.041538913 NANOS1 340719 0.461103276 2.439592894 4.174016588 0.041048378 NCR3 259197 0.466567018 3.187240869 4.976607304 0.02569232 NME3 4832 0.467678294 2.533900686 5.271640226 0.02167558 NR3C2 4306 0.576442192 3.699128244 4.562732679 0.032674898 NSUN5P2 260294 0.453077844 4.579884771 6.238757689 0.012498412 OBSCN 84033 0.642947635 5.12205436 5.742337454 0.016560739 OXNAD1 92106 0.487053912 5.903385473 5.243635471 0.022027197 P2RY14 9934 0.682378933 4.305911198 5.331791262 0.020939853 P4HTM 54681 0.48632341 2.878324069 5.879064137 0.015321964 PAFAH2 5051 0.553503529 4.059666499 6.598696879 0.010205343 PASK 23178 0.541590542 4.058773836 4.120811548 0.042358754 PATJ 10207 0.62171536 5.126911784 5.142909587 0.023341497 PCED1B 91523 0.441747044 3.867548591 4.031407981 0.044660654 PCED1B-AS1 100233209 0.542137228 4.403933698 6.462444538 0.011017797 PDCD4-AS1 282997 0.477718503 2.084128846 5.776237386 0.016244279 PDZD4 57595 0.569879276 2.697950683 6.414394063 0.011319895 PLCG1 5335 0.529472373 6.024655151 4.810165398 0.02829233 PMAIP1 5366 0.554440027 3.191575987 7.515844346 0.006115861 POLRMT 5442 0.473076276 2.493618228 4.772338559 0.028920516 PRKCQ-AS1 439949 0.659970635 4.884041671 12.18890283 0.000480747 PROCA1 147011 0.576986849 2.204972305 6.099990394 0.013518262 PTP4A3 11156 0.44253125 3.256101089 4.378249995 0.036400352 PTPRCAP 5790 0.450465332 4.310373502 4.71557194 0.029890621 PYROXD2 84795 0.686971952 2.810870672 8.714650916 0.003156629 RAB44 401258 0.41003764 3.900433943 3.975143699 0.046176513 RELL2 285613 0.595922847 1.93083473 8.616811502 0.003330744 RIC3 79608 0.454275928 2.982411292 4.14160698 0.041841431 RPL34 6164 0.796406181 7.555121141 14.68187643 0.000127264 SCARNA17 677769 0.443489266 6.100994157 5.300130218 0.02132383 SEMA4C 54910 0.481329086 3.232111312 4.11631327 0.042471538 SEMA7A 8482 0.803184843 3.626311513 11.06093219 0.000881658 SGK1 6446 0.58778866 6.20467268 6.321938187 0.011925321 SHISA4 149345 0.661240444 3.142806197 4.390125943 0.036147643 SIGLEC10 89790 0.596810907 5.896591942 5.241733744 0.022051288 SIT1 27240 0.577112697 3.891385062 7.534237622 0.006053735 SLC26A11 284129 0.438742511 2.814087491 4.584646163 0.032259631 SLC29A1 2030 0.958795134 3.988007545 16.15425462 5.84E-05 SNHG15 285958 0.468359402 3.112682826 5.879602604 0.015317278 SNORD116-20 100033431 0.499969509 2.693810087 6.54134073 0.010539589 SORD 6652 0.631606633 4.239092186 10.74384162 0.001046269 SPIN3 169981 0.654460655 3.060397153 7.245215678 0.007109017 SPNS3 201305 0.77077084 3.012571747 13.72975319 0.000211084 SREBF1 6720 0.471297229 3.851316636 5.004258487 0.025285033 STMN3 50861 0.462453168 3.904255588 6.079782813 0.013673758 TAF6L 10629 0.442463677 1.705852136 4.647844097 0.031092574 TBC1D4 9882 0.530238078 5.121224418 4.397242432 0.035997091 TEX30 93081 0.50832331 1.709229898 5.927346159 0.014907676 TMEM102 284114 0.417953144 1.93338456 4.526448163 0.033374818 TMEM116 89894 0.528366565 2.791066969 4.277139601 0.038628303 TNFRSF25 8718 0.851183329 4.513161341 8.939317745 0.002790969 TNS2 23371 0.473295336 1.946469238 4.719944428 0.029814707 TP73-AS1 57212 0.4047737 3.113201734 4.169457332 0.041158981 TRABD2A 129293 0.63533496 4.63031619 5.134632581 0.023453051 TRAF1 7185 0.456946972 4.866986165 4.221023879 0.039926061 TRIM73 375593 0.491416011 2.828859561 6.000670273 0.014300444 TRPC6 7225 0.81103607 1.76855582 14.33816614 0.000152737 TSHZ2 128553 0.579756837 3.466932779 3.906011301 0.048113662 TSPYL2 64061 0.558566627 3.711064032 7.906008122 0.004927088 WDR24 84219 0.409535228 2.058581893 3.863070726 0.049359911 YES1 7525 0.427904992 3.168660952 4.364445918 0.036696415 ZAP70 7535 0.559824752 5.667480845 4.310375939 0.03788059 ZC3H12D 340152 0.501642741 3.916039624 4.239897908 0.039484541 ZNF540 163255 0.551833426 2.619852814 7.036559895 0.007986228 ZNF792 126375 0.505998173 3.799821687 4.996788949 0.02539439 ZNF846 162993 0.453844731 2.351561644 4.37460232 0.036478342 Table S8: Gene Ontologies with significant enrichment for genes repressed in response to AZA treatment. category over_represented_pvalue numDEInCat numInCat term ontology GO:0006464 5.36E-06 126 2027 cellular protein modification process BP GO:0036211 5.36E-06 126 2027 protein modification process BP GO:0044257 5.59E-06 38 407 cellular protein catabolic process BP GO:0030163 9.38E-06 42 480 protein catabolic process BP GO:0006511 1.18E-05 34 357 ubiquitin-dependent protein catabolic process BP GO:0008283 1.42E-05 67 927 cell proliferation BP GO:0051603 1.59E-05 36 394 proteolysis involved in cellular protein catabolic process BP GO:0019941 1.99E-05 34 366 modification-dependent protein catabolic process BP GO:0043632 2.50E-05 34 370 modification-dependent macromolecule catabolic process BP GO:0007049 2.78E-05 77 1129 cell cycle BP GO:0044772 3.73E-05 34 380 mitotic cell cycle phase transition BP GO:0044770 4.89E-05 34 385 cell cycle phase transition BP GO:0020027 4.98E-05 5 11 hemoglobin metabolic process BP GO:0043412 5.18E-05 126 2119 macromolecule modification BP GO:0006778 5.18E-05 8 33 porphyrin-containing compound metabolic process BP GO:0014731 3.66E-06 5 7 spectrin-associated cytoskeleton CC GO:0005829 4.61E-05 119 2002 cytosol CC Table S9: Significant GO terms for a sub-sample of 3 AZA-treated patients.

Significant GO terms (FDR P <0.05) for three AZA-treated patients GO term description GO:0002682 regulation of immune system process GO:0002684 positive regulation of immune system process GO:0050865 regulation of cell activation GO:0051249 regulation of lymphocyte activation GO:0046649 lymphocyte activation GO:0050867 positive regulation of cell activation GO:0045321 leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002694 regulation of leukocyte activation Table S10: repressed or over-expressed genes common to both treatments.

Genes significantly repressed and common to LDAA and AZA treatments LDAA AZA Gene.SymbolEntrez.ID logFC logCPM LR PValue Gene.SymbolEntrez.ID logFC logCPM LR PValue ANKRD22 118932 -1.30262 2.908321 14.63367 0.000131 ANKRD22 118932 -0.93769 3.036112 8.277678 0.004014 ANXA3 306 -0.89935 6.677726 4.700177 0.03016 ANXA3 306 -0.63242 6.744139 4.487778 0.034138 ARHGAP24 83478 -0.47704 4.204166 4.541047 0.033091 ARHGAP24 83478 -0.61502 4.075328 5.188304 0.022739 BMX 660 -0.78496 3.69391 6.086543 0.013622 BMX 660 -0.63579 3.770803 4.643451 0.031172 C11orf42 160298 -0.92754 1.973937 14.0104 0.000182 C11orf42 160298 -0.54978 1.270685 5.166157 0.023031 CD163 9332 -0.71745 5.788826 5.982041 0.014452 CD163 9332 -0.70474 5.898512 6.894821 0.008645 CLEC4D 338339 -0.99175 5.332475 10.15004 0.001443 CLEC4D 338339 -0.66184 5.6867 5.437061 0.019714 DHCR24 1718 -0.46546 2.145397 4.414864 0.035627 DHCR24 1718 -0.62924 1.967846 6.989163 0.0082 FCAR 2204 -0.83173 6.015764 9.218964 0.002395 FCAR 2204 -0.56406 5.602807 5.27634 0.021617 FKBP5 2289 -0.89059 7.536709 3.891906 0.048519 FKBP5 2289 -0.87239 7.399986 6.325845 0.011899 GPR141 353345 -0.91172 4.400577 8.201598 0.004185 GPR141 353345 -0.515 4.076974 4.972312 0.025756 GUCY2C 2984 -0.90454 3.10007 15.32604 9.05E-05 GUCY2C 2984 -0.50308 2.647005 4.616729 0.031662 IL18R1 8809 -1.13428 5.814519 7.126587 0.007595 IL18R1 8809 -0.84741 6.098216 4.61474 0.031698 IL18RAP 8807 -0.99136 6.225387 5.162729 0.023077 IL18RAP 8807 -0.57645 7.321694 5.106392 0.023838 IRAK3 11213 -0.79775 7.974866 6.41079 0.011343 IRAK3 11213 -0.69087 7.837022 6.835898 0.008934 LILRA5 353514 -0.47814 6.923954 4.483503 0.034224 LILRA5 353514 -0.44392 6.930574 4.279348 0.038578 MCEMP1 199675 -1.2669 4.83154 7.318133 0.006826 MCEMP1 199675 -0.74888 5.023795 6.561338 0.010422 MFSD13A 79847 -0.44624 3.32492 4.066296 0.043747 MFSD13A 79847 -0.43581 2.504419 3.852795 0.049663 MKI67 4288 -0.52813 5.051792 4.28314 0.038492 MKI67 4288 -0.90459 4.947455 7.002257 0.008141 MS4A4A 51338 -0.97526 1.64377 10.91792 0.000952 MS4A4A 51338 -0.91136 2.036095 12.57509 0.000391 NCR1 9437 -0.50799 2.87056 4.286908 0.038407 NCR1 9437 -0.48692 2.76721 6.644247 0.009948 NLRC4 58484 -0.71361 6.163862 5.031979 0.024883 NLRC4 58484 -0.56243 6.050535 5.139571 0.023386 NME8 51314 -0.68 3.486427 10.80873 0.00101 NME8 51314 -0.73729 2.651313 12.30294 0.000452 PFKFB3 5209 -0.81697 7.198426 8.165028 0.004271 PFKFB3 5209 -0.47126 6.658621 5.500732 0.019009 PLSCR1 5359 -0.93283 6.5812 10.78403 0.001024 PLSCR1 5359 -0.46014 6.334063 4.776451 0.028852 SGMS2 166929 -0.62247 3.937307 6.737909 0.009439 SGMS2 166929 -0.51242 4.438996 5.149098 0.023258 SORT1 6272 -0.54863 6.195799 5.018142 0.025083 SORT1 6272 -0.47871 6.180364 4.160261 0.041383 TBC1D8 11138 -0.80514 4.819531 7.495456 0.006185 TBC1D8 11138 -0.63804 4.739655 8.657508 0.003257 TENM1 10178 -0.61423 4.811187 11.63676 0.000647 TENM1 10178 -0.5847 4.586765 5.886851 0.015254 TMEM200B 399474 -0.72443 3.694557 12.1079 0.000502 TMEM200B 399474 -1.23507 3.675639 13.56809 0.00023

Genes significantly over-expressed and common to LDAA and AZA treatments LDAA AZA Gene.SymbolEntrez.ID logFC logCPM LR PValue Gene.SymbolEntrez.ID logFC logCPM LR PValue AEN 64782 0.759997 3.22491 12.471 0.000413 AEN 64782 0.520807 3.724155 6.498831 0.010795 AGAP7P 653268 0.481346 4.470093 4.328361 0.037482 AGAP7P 653268 0.4988 4.308465 6.354005 0.011712 APBB1 322 0.502463 3.633876 5.288898 0.021462 APBB1 322 0.656314 4.017014 8.060532 0.004524 AQP3 360 0.440363 3.941565 4.585171 0.03225 AQP3 360 0.526345 4.509418 5.368052 0.020509 CACNB4 785 0.821338 2.175788 4.240439 0.039472 CACNB4 785 0.499198 2.162352 4.268806 0.038818 CD3D 915 0.828525 4.776337 11.33283 0.000761 CD3D 915 0.667616 5.756006 5.92532 0.014925 CD52 1043 0.427396 6.61009 4.278087 0.038607 CD52 1043 0.453892 6.901896 4.825442 0.028043 CD6 923 0.509369 5.138261 4.111517 0.042592 CD6 923 0.598997 5.181743 4.848113 0.027676 CD7 924 0.713864 3.358641 6.862495 0.008802 CD7 924 0.531243 3.815029 6.336755 0.011826 CD8B 926 0.552922 3.618536 8.879201 0.002884 CD8B 926 0.641454 4.367052 5.271383 0.021679 CDKN1A 1026 0.466799 4.23759 4.112962 0.042556 CDKN1A 1026 0.487805 4.108136 4.670521 0.030685 GOLGA2P10 80154 0.550837 2.216102 5.739517 0.016587 GOLGA2P10 80154 0.709178 2.198263 8.456372 0.003638 GRAP 10750 0.426694 4.102498 4.666007 0.030765 GRAP 10750 0.431211 4.231502 4.166774 0.041224 ICOS 29851 0.521248 3.126591 4.634289 0.031339 ICOS 29851 0.641313 3.85137 4.923929 0.026487 LCK 3932 0.539901 5.688336 7.765066 0.005327 LCK 3932 0.552845 6.309108 4.555249 0.032818 LDHB 3945 0.445683 6.093943 5.795437 0.016068 LDHB 3945 0.40013 7.205655 3.941589 0.047106 NME3 4832 0.520735 2.186644 5.053319 0.024579 NME3 4832 0.467678 2.533901 5.27164 0.021676 PDZD4 57595 0.58085 2.526244 7.493893 0.006191 PDZD4 57595 0.569879 2.697951 6.414394 0.01132 PMAIP1 5366 0.499855 3.062532 3.907056 0.048084 PMAIP1 5366 0.55444 3.191576 7.515844 0.006116 PTP4A3 11156 0.550074 3.41254 7.065342 0.007859 PTP4A3 11156 0.442531 3.256101 4.37825 0.0364 PTPRCAP 5790 0.574701 4.351781 5.632654 0.017629 PTPRCAP 5790 0.450465 4.310374 4.715572 0.029891 SCARNA17 677769 0.433748 6.017743 5.343039 0.020805 SCARNA17 677769 0.443489 6.100994 5.30013 0.021324 SGK1 6446 0.598074 5.960978 5.111732 0.023765 SGK1 6446 0.587789 6.204673 6.321938 0.011925 SHISA4 149345 1.191469 2.499924 11.26131 0.000791 SHISA4 149345 0.66124 3.142806 4.390126 0.036148 SIT1 27240 0.56386 3.230966 7.543715 0.006022 SIT1 27240 0.577113 3.891385 7.534238 0.006054 STMN3 50861 0.450037 3.692587 6.453179 0.011075 STMN3 50861 0.462453 3.904256 6.079783 0.013674 TNFRSF25 8718 0.412678 4.060702 4.36863 0.036606 TNFRSF25 8718 0.851183 4.513161 8.939318 0.002791 Table S11: GO terms associated with differentially-expressed gene lists common to both treatments.

Summarised GO terms associated with repressed genes common to both treatments GO term Description Frequency GO:0055114 oxidation-reduction process 15.04% GO:0006259 DNA metabolic process 6.34% GO:0016310 phosphorylation 6.30% GO:0008104 protein localization 1.72% GO:0006457 protein folding 0.86% GO:0016311 dephosphorylation 0.78% GO:0046835 carbohydrate phosphorylation 0.27% GO:0006366 transcription from RNA polymerase II promoter 0.24% GO:0006898 receptor-mediated endocytosis 0.17% GO:0009888 tissue development 0.13% GO:0008283 cell proliferation 0.11% GO:0016567 protein ubiquitination 0.11% GO:0061077 chaperone-mediated protein folding 0.11% GO:0007265 Ras protein signal transduction 0.10% GO:0016050 vesicle organization 0.04% GO:0008202 steroid metabolic process 0.04% GO:0006165 nucleoside diphosphate phosphorylation 0.04% GO:0001503 ossification 0.03% GO:0051260 protein homooligomerization 0.03% GO:0006000 fructose metabolic process 0.02% GO:0034605 cellular response to heat 0.02% GO:0031639 plasminogen activation 0.01% GO:0006003 fructose 2,6-bisphosphate metabolic process 0.01% GO:0006182 cGMP biosynthetic process 0.01% GO:0016045 detection of bacterium 0.00% GO:0030212 hyaluronan metabolic process 0.00% GO:0051005 negative regulation of lipoprotein lipase activity 0.00% GO:0070269 pyroptosis 0.00% GO:1990705 cholangiocyte proliferation 0.00% GO:0030101 natural killer cell activation 0.00% GO:0042987 amyloid precursor protein catabolic process 0.00% GO:0038083 peptidyl-tyrosine autophosphorylation 0.00% GO:0032509 endosome transport via multivesicular body sorting pathway 0.00% GO:0007168 receptor guanylyl cyclase signaling pathway 0.00% GO:0006968 cellular defense response 0.00% GO:0035456 response to interferon-beta 0.00% GO:0046323 glucose import 0.00% GO:0030317 sperm motility 0.00% GO:0017121 phospholipid scrambling 0.00% GO:0006659 phosphatidylserine biosynthetic process 0.00% GO:0045071 negative regulation of viral genome replication 0.00% GO:0030148 sphingolipid biosynthetic process 0.00% GO:0061621 canonical glycolysis 0.00%

Summarised GO terms associated with over-expressed genes common to both treatments GO term Description Frequency GO:0006810 transport 17.38% GO:0055114 oxidation-reduction process 15.04% GO:0005975 carbohydrate metabolic process 5.98% GO:0006950 response to stress 4.12% GO:0090305 nucleic acid phosphodiester bond hydrolysis 2.51% GO:0016032 viral process 1.74% GO:0006220 pyrimidine nucleotide metabolic process 0.73% GO:0050790 regulation of catalytic activity 0.65% GO:0006814 sodium ion transport 0.36% GO:0006915 apoptotic process 0.25% GO:0019674 NAD metabolic process 0.25% GO:0072593 reactive oxygen species metabolic process 0.20% GO:0006898 receptor-mediated endocytosis 0.17% GO:0035335 peptidyl-tyrosine dephosphorylation 0.15% GO:0046854 phosphatidylinositol phosphorylation 0.11% GO:0042127 regulation of cell proliferation 0.08% GO:0007267 cell-cell signaling 0.06% GO:0010498 proteasomal protein catabolic process 0.05% GO:0006183 GTP biosynthetic process 0.04% GO:0006089 lactate metabolic process 0.03% GO:0001558 regulation of cell growth 0.02% GO:0050821 protein stabilization 0.02% GO:0000086 G2/M transition of mitotic cell cycle 0.01% GO:0006833 water transport 0.01% GO:0071918 urea transmembrane transport 0.01% GO:0007219 Notch signaling pathway 0.01% GO:0048015 phosphatidylinositol-mediated signaling 0.01% GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 0.00% GO:0010039 response to iron ion 0.00% GO:0010917 negative regulation of mitochondrial membrane potential 0.00% GO:0045730 respiratory burst 0.00% GO:0007616 long-term memory 0.00% GO:0001771 immunological synapse formation 0.00% GO:0090399 replicative senescence 0.00% GO:0007528 neuromuscular junction development 0.00% GO:0050760 negative regulation of thymidylate synthase biosynthetic process 0.00% GO:0015793 glycerol transport 0.00% GO:2000278 regulation of DNA biosynthetic process 0.00% GO:0055093 response to hyperoxia 0.00% GO:2000379 positive regulation of reactive oxygen species metabolic process 0.00% GO:0038083 peptidyl-tyrosine autophosphorylation 0.00% GO:0033158 regulation of protein import into nucleus, translocation 0.00% GO:0006883 cellular sodium ion homeostasis 0.00% GO:0034198 cellular response to amino acid starvation 0.00% GO:0007019 microtubule depolymerization 0.00%