UCLA STEIN EYE INSTITUTE

ANNUAL REPORT 2018–2019

ANNUAL REPORT 2018–2019ANNUAL REPORT

E R N E W F R O N T I S I N V I S I O N O R I N G C A R E E X P L

UCLA DEPARTMENT OF OPHTHALMOLOGY DAVID GEFFEN SCHOOL OF MEDICINE AT UCLA UCLA Stein Eye Institute Vision-Science Campus UCLA Stein Eye Institute ANNUAL REPORT

July 1, 2018–June 30, 2019

DIRECTOR Bartly J. Mondino, MD

MANAGING EDITOR Tina-Marie Gauthier c/o Stein Eye Institute 100 Stein Plaza, UCLA Los Angeles, California 90095–7000 [email protected]

PUBLICATION COMMITTEE Anthony C. Arnold, MD Kevin M. Miller, MD Alfredo A. Sadun, MD, PhD Alapakkam P. Sampath, PhD M. Gail Summers

CONTRIBUTING EDITORS Teresa Closson Susan Ito Sarah Johnson Peter J. López Ellen Pascual

CONTRIBUTING WRITERS Dan Gordon Harlan Lebo

PHOTOGRAPHY Reed Hutchinson Robin Weisz

DESIGN Robin Weisz/Graphic Design

PRINTING Marina Graphic Center

To view the Annual Report online, visit: www.uclahealth.org/Eye/annual-report

For more information about the UCLA Department of Ophthalmology, see: www.uclahealth.org/eye/

©2019 by the Regents of the University of California. All rights reserved. 1 Exploring New Frontiers in Vision Care

5 A Year in Review

19 Philanthropy

27 Eye Health Programs

35 Faculty and Colleagues

71 Research and Funding

97 About the Institute LETTER FROM THE CHAIR

This academic year, the Stein Eye Institute and the Doheny Eye Institute marked the five-year anniversary of our historic affiliation. In addition to broadening patient care and aligning the strengths of two world-renowned institutions, the partnership is also taking the UCLA Department of Ophthalmology to new heights—literally.

As you’ll read in our feature article, Alex Huang, MD, PhD, and Department colleagues are working with NASA to counteract spaceflight-associated neuro-ocular syndrome, a visual issue that is hindering efforts to send astronauts on long-duration space missions.

Closer to home, we welcomed six new faculty members to the UCLA Department of Ophthalmology. Three are researchers who will be advancing our knowledge of vision science and technology at the Doheny Eye Institute, and three are clinicians who will be providing patient care at the Stein Eye Institute, as well as training the next generation of ophthalmologists at Stein Eye and at UCLA-affiliated teaching hospitals.

Private funding is critical to our ability to advance science and medicine in order to preserve and restore vision. Our generous donors and friends recognize this need and provide support for our sight-saving endeavors.

I hope you enjoy reading this Annual Report and learning more about our activities from this year.

Sincerely, EXPLORING NEW FRONTIERS Bartly J. Mondino, MD IN VISION CARE Bradley R. Straatsma, MD, Endowed Chair in Ophthalmology Director, Stein Eye Institute Chairman, UCLA Department of Ophthalmology Affiliation Chairman, Doheny Eye Institute EXPLORING NEW FRONTIERS IN VISION CARE

NASA Collaboration Aims to Counteract Potential Vision Complication in Long Spaceflights BECAUSE OF THEIR PROLONGED EXPOSURE TO A WEIGHTLESS ENVIRONMENT, A SIGNIFICANT PROPORTION OF ASTRONAUTS WITH THE INTERNATIONAL SPACE STATION HAVE EXPERIENCED VISUAL COMPLICATIONS.

Photos courtesy of NASA NASA astronaut Nick Hague floats inside Europe’s Columbus laboratory module. UCLA Department of Ophthalmology faculty member is collaborating with NASA—the National Aeronautics and Space Administration—to develop a countermeasure to a vision-related problem that is currently Ahindering the effort to send astronauts on a mission to Mars, or on other extended journeys into space. Because of their prolonged exposure to a weightless environment, a significant proportion of astronauts with the International Space Station have experienced visual complications. Many of these effects—including bleeding, folds in the back of the eye, and changes in the glasses prescription—are short-term and can be resolved when the astronauts return to Earth. But the most concerning change involves disc edema, or swelling in the nerves of the eye, a cornerstone of a condition referred to as spaceflight-associated neuro-ocular syndrome (SANS). “A change in eyeglass prescription or a tiny bleed in the retina can be recovered, but a swollen disc can potentially lead to permanent damage,” explains Alex Huang, MD, PhD, Doheny Eye Center UCLA clinician and scientist. “This is one of the main reasons we don’t have long-haul spaceflight right now. We need to learn how to address this problem, either through a treatment or a countermeasure that prevents it.” Dr. Huang is a glaucoma specialist whose research has focused on fluid flow in the eye. In collaboration with an industry partner, Heidelberg Engineering, he developed a device modification, called a FLEX, which situates necessary imaging equipment for real-time ocular fluid flow assessment in patients with and without glaucoma, in a variety of positions. That attracted the interest of NASA, which asked Dr. Huang to take the lead in developing and studying a countermeasure for SANS, which is believed to be caused by the redistribution of fluid to the head. “If fluid is redistributing to the astronaut’s head in space, the best way to model that on Earth is to lay people with their feet up and head down—the so-called head- down tilt—but standard imaging equipment is designed for people sitting upright,” Dr. Huang says. “When the scientists at NASA realized that we not only have this equipment but are vision scientists at the Doheny Image Reading Center—a center

2 UCLA STEIN EYE INSTITUTE | A Year in Review known for its strong imaging—they were very interested in collaborating.” Although several SANS causes have been hypothesized, the headward fluid shift that occurs in the weightlessness environment is currently seen as the most likely culprit for the ocular-related changes during long-duration space- flight. “On Earth, where there is gravity, On Earth, where there is gravity, fluid is always pulled to our feet. In fluid is always pulled to our feet,” Dr. the weightless environment of space, it’s been estimated that there is Huang explains. “In the weightless envi- ronment of space, it’s been estimated a two-liter shift of fluid to the head. Given that this headward shift is that there is a two-liter shift of fluid to the leading hypothesis for the cause of the problems we see in the the head. Given that this headward shift eyes of astronauts after long-duration flights, our focus in developing is the leading hypothesis for the cause of the problems we see in the eyes of a countermeasure is to manipulate this fluid shift. astronauts after long-duration flights, our focus in developing a countermeasure ALEX HUANG, MD, PHD Assistant Professor of Ophthalmology is to manipulate this fluid shift.” UCLA Department of Ophthalmology The potentially mitigating counter- measure Dr. Huang’s team has studied involves the use of venoconstrictive thigh cuffs (VTCs). The Russian space agency developed a type of VTC called a braslet to keep fluid in the limbs, with some demonstrated success. But the braslet is limiting physically in that it Photos courtesy of NASA requires tying the legs together tightly to compress the fluid and prevent it from shifting; moreover, it was not known how VTCs, including braslets, would affect headward fluid shift as it relates to ocu- lar physiology. Dr. Huang and his colleagues have investigated the ocular implications of using single-leg mobility-enabling thigh cuffs as a SANS countermeasure. “The idea is to pump up the cuff on the leg at a level that maintains the flow of blood but slows the movement of the fluid from the feet to the head to prevent the redis- tribution,” Dr. Huang says. At the Doheny Eye Center UCLA– Pasadena, Dr. Huang’s team tested 40 healthy research subjects without known ocular disease for 10 minutes each under four conditions: sitting posture, supine posture (lying on one’s back), head- down tilt posture—meant to simulate the headward fluid shift that occurs in micro- gravity conditions—and head-down tilt posture with the thigh cuffs. In the study, intra­ocular pressure (IOP) increased sig- nificantly when subjects went from the sitting to the supine position, and further increased when they went from supine to head-down tilt position. Wearing the thigh cuffs during the head-down tilt Flight Engineer Christina Koch of NASA playfully demonstrates how fluids behave in the posture resulted in a significantly lower weightless environment of microgravity aboard the International Space Station.

A Year in Review | UCLA STEIN EYE INSTITUTE 3 IOP compared to not wearing the cuffs in headward fluid shift is the leading hypoth- that position, though it was higher than esis, other causes have been proposed, when in the seated position. Using the such as radiation from the sun and ele- FLEX, the researchers found that sub­ vated carbon dioxide levels. “Typically, foveal choroidal thickness—also known research first aims to understand what’s to elevate during the head-down tilt posi- happening, and then to develop a treat- tion—was significantly reduced when ment or countermeasure,” Dr. Huang the research subjects were wearing the says. “But in this case, there is such an thigh cuffs. urgency to address this issue that we are “It’s important to note that we weren’t doing both at the same time. Whether recreating SANS on Earth—no one was our goal is going to Mars, which would going to get a swollen nerve from lying be about an 18-month commitment, or on their back with their feet upright for pursuing a lunar station, we have to solve 10–20 minutes,” Dr. Huang says. “But it this problem. For any future manned mis- is encouraging that in this acute model, sions beyond low Earth orbit, we need where eye pressure and choroid thick- countermeasures to reverse or prevent ness were indicators of fluid shift, the SANS.” countermeasure seemed to reverse The Doheny Eye Institute signed a those changes.” The next step, Dr. Huang historic partnership with UCLA in 2013— says, is to test the thigh cuffs over a much joining forces with the Stein Eye Insti- longer period of time, and ultimately to tute and creating the nation’s largest study them in space. academic affiliation. Forming the UCLA As part of a seven-year grant from Department of Ophthalmology, the com- NASA, Dr. Huang and his colleagues are bined strengths of the two Institutes investigating SANS countermeasures are expanding the care of patients and at the same time they are conducting broadening efforts in vision science and studies to ensure that the hypothesis technology. for the SANS cause is correct. Although

Dr. Alex Huang (center, pink tie) and Dr. SriniVas Sadda, president and chief scientific officer of the Doheny Eye Institute (center, dark blue suit), are shown with Dr. Brandon Macias (immediate left of Dr. Huang)—one of the lead NASA scientists on the collaborative project—and his team.

4 UCLA STEIN EYE INSTITUTE | A Year in Review A Year in Review JULY 1, 2018–JUNE 30, 2019 Institute News

Drs. Anne Coleman and Lynn Gordon Setting the Agenda for Ophthalmology Anne L. Coleman, MD, PhD, and Lynn K. Gordon, MD, PhD, have been announced as leading officers for the American Academy of Ophthalmology (AAO)— Dr. Coleman as president-elect of the AAO and Dr. Gordon as chair of the AAO Council. “It is a wonderful opportunity to serve our patients, society, and profession by promoting our mission of preserving Dr. Anne Coleman, AAO sight, especially in the auspicious year President-Elect 2020,” says Dr. Coleman, The Fran and Ray Stark Foundation Chair in Ophthal- mology, of being nominated president- elect of the AAO in 2019 and president in 2020. “The Academy and the Council are in the best position to protect our patients and ensure that their care represents the greatest in skill, utmost compassion, and visionary innovations,” says Dr. Gordon, Vernon O. Underwood Family Chair in Dr. Bradley Straatsma Ophthalmology. Honored as a Living Legend “Having these influential positions held by faculty from one department is Founding Chair of the UCLA Department of Ophthalmology a distinction of the highest order,” says and Founding Director of the Stein Eye Institute, Bradley R. Chair Bartly J. Mondino, MD. “I am proud Dr. Lynn Gordon, Chair of the Straatsma, MD, JD, was celebrated as a “Living Legend in the UCLA Department of Ophthalmol- AAO Council Ophthalmology” in the October 2018 issue of the Indian Jour- ogy is represented by the leadership nal of Ophthalmology. advanced by Drs. Coleman and Gordon.” The cover article highlights Dr. Straatsma’s academic achievements and contributions to the field. The issue also includes Dr. Straatsma’s guest editorial “Precision Medicine and Clinical Ophthalmology” and republication of the article “Mortality After Deferral of Treatment or No Treatment for Creating Policies to Benefit Choroidal Melanoma” by Dr. Straatsma and co-­authors for the Ophthalmology’s Future Collaborative Ocular Melanoma Study Group, published in the JoAnn A. Giaconi, MD, and Stacy L. Pineles, MD, have been July 2003 issue of the American Journal of Ophthalmology. appointed to leadership positions with the Association of Uni- versity Professors of Ophthalmology (AUPO), an organization dedicated to ensuring the best possible vision for the public. Dr. Giaconi, health sciences associate clinical professor of oph- thalmology, is president of the AUPO Medical Student Educa- tors Council, and Dr. Pineles, Jerome and Joan Snyder Chair in Ophthalmology, is member-at-large of the AUPO Program Directors Council. Drs. Giaconi and Pineles follow in the footsteps of Stein Eye Director Bartly J. Mondino, MD, who served as executive vice president of the AUPO for 10 years and was honored for taking the organization to a new level of performance and relevance.

6 UCLA STEIN EYE INSTITUTE | A Year in Review Awards and Honors

American Academy of Faculty Honors Brian A. Francis, MD, MS, health sci- Ophthalmology Awards ences clinical professor, gave The Moses Anthony C. Arnold, MD, Mary Oakley Carl Wilensky Lecture at the 54th Annual UCLA Department of Ophthalmology Foundation Chair in Neurodegener- C.S. O’Brien Professor and 41st Annual faculty and alumni were honored for their ative Diseases, was chair of the 2018 Tulane Eye Alumni Day meeting on contributions to the profession at the Sally ­Letson Symposium in Neuro-­ June 8, 2019, at Tulane University in October 27–30, 2018, American Acad- Ophthalmology in Ottawa, Canada, and New ­Orleans, Louisiana. emy of Ophthalmology (AAO) annual presented the symposium’s keynote meeting in Chicago, Illinois. address, the A. Gardner Watson Lecture, on September 14, 2018. Gary N. Holland, MD, Jack H. Skirball Chair in Ocular Inflammatory Diseases, LIFE ACHIEVEMENT HONOR AWARD presented the 35th G. Richard O’Connor Ava K. Bittner, OD, PhD, associate pro- Tamara R. Fountain, MD Lecture “Ocular Toxoplasmosis: 35 Years fessor of ophthalmology, was appointed of Discovery (1984–2019)” at the annual Gary N. Holland, MD as the Smotrich Family Optometric meeting of the H. Bruce Ostler Associa- ­Clinician-Scientist Chair on February 4, tion of Proctor Fellows on June 15, 2019, SENIOR ACHIEVEMENT AWARD 2019. Dr. Bittner also received the 2019 in San Francisco, California. Clinical Research Award for $100,000 Craig H. Kliger, MD from the American Academy of Optome- Lawrence S. Morse, MD, PhD try to conduct a multicenter, randomized Jean-Pierre Hubschman, MD, asso- controlled trial of tele-rehabilitation for ciate professor of ophthalmology, was Peter A. Quiros, MD low vision. awarded a $2.5 million R01 grant from Kenneth David Steinsapir, MD the National Eye Institute of the United States National Institutes of Health Nicholas C. Brecha, PhD, Distinguished ACHIEVEMENT AWARD effective February 1, 2019, for his project Professor of Neurobiology, Ophthal- “Vitreoretinal Surgery via Robotic Micro- Olivia L. Lee, MD mology, and Medicine, received the surgical System with Image Guidance, Boycott Prize in recognition of career Eric H. Souied, MD, PhD Force Feedback, Virtual Fixture, and achievement in retinal neurobiology at Augmented Reality.” Federico G. Valez, MD the Federation of American Societies of Experimental Biology (FASEB) meeting SECRETARIAT AWARD on Retinal Neurobiology and Visual Michael S. Ip, MD, professor of ophthal- Processing on June 28, 2018, in Olean, mology, was appointed as the Gavin S. Anthony J. Aldave, MD New York. Herbert Endowed Chair, on March 22, Joseph Caprioli, MD 2019. Roy S. Chuck, MD, PhD Anne L. Coleman, MD, PhD, The Fran and Ray Stark Foundation Chair in Oph- Ralph D. Levinson, MD, health sciences Gary N. Holland, MD thalmology, was named an Association clinical professor of ophthalmology, was Don O. Kikkawa, MD for Research in Vision and Ophthalmol- honored with the S. Rodman Irvine Prize ogy (ARVO) Gold Fellow. The distinc- at the UCLA Department of Ophthalmol- Ralph D. Levinson, MD tion honors Dr. Coleman’s exemplary ogy Clinical and Research Seminar on contributions to the organization and was Stephen D. McLeod, MD June 7, 2019, in Los Angeles, California. received on April 28, 2019, in Vancouver, The award recognizes demonstrated Steven Nusinowitz, PhD Canada. excellence in professional actions and exemplary dedication to teaching future generations of ophthalmologists. Sophie X. Deng, MD, PhD, professor of ophthalmology, received an Achieve- ment Award from Asian-Pacific Academy of Ophthalmology at their March 8, 2019, annual meeting in Bangkok, Thailand.

A Year in Review | UCLA STEIN EYE INSTITUTE 7 Tara A. McCannel, MD, PhD, director David Sarraf, MD, health sciences New Faculty Appointments of the Ophthalmic Oncology Center clinical professor of ophthalmology, and health sciences associate clinical presented the keynote lecture “RAP: The UCLA Department of Ophthalmology professor of ophthalmology, was the Advanced Retinal Imaging of Type 3 NV” is pleased to welcome three researchers keynote speaker for the Canadian Oph- at the 6th International OCT Angiogra- who will be advancing our knowledge thalmological Society Annual Meeting phy and Advances in OCT Congress on of vision science and technology at the and Exhibition on June 16, 2019, in December 14, 2018, in Rome, Italy. Doheny Eye Institute: Quebec, Canada. Dr. Sarraf also presented both the ff Steven A. Barnes, PhD, Professor of keynote lecture “PAMM, OHMM and Ophthalmology the Ischemic Cascade: Understanding Bartly J. Mondino, MD, Bradley R. ff Ram Kannan, PhD, Adjunct Professor the Organization of the Retinal Capillary Straatsma, MD, Endowed Chair in of Ophthalmology Ophthalmology, and chair of the UCLA Plexus” and the EVRS award lecture Department of Ophthalmology, pre- “OCT Angiography: Navigating the Traps ff Yuhua Zhang, PhD, Associate sented the keynote Steven M. Podos, and Pitfalls of Image Interpretation” at the Professor of Ophthalmology European VitreoRetinal Society annual MD, Lecture “Ocular Cicatricial Pemphi- The Department also welcomes three meeting on June 28, 2019, in Lisbon, goid” at the Icahn School of Medicine ­clinician-researchers who will be pro- Portugal. at Mount Sinai on May 30, 2019, in viding patient care at the UCLA Stein New York, New York. Eye Institute and/or related teaching Steven D, Schwartz, MD, The Ahmanson hospitals: Kouros Nouri-Mahdavi, MD, MS, asso- Chair in Ophthalmology, presented the ff Ava K. Bittner, OD, PhD, Smotrich ciate professor of ophthalmology, and APEC 100 Year Anniversary Lecture “The Optometric Clinician-Scientist Chair, his co-principal investigators, received Truth About Stem Cells” at the APEC Associate Professor of Ophthalmology a 2019 UCLA Innovation Fund Award Hospital Centennial on August 9, 2018, in of $200,000 for their development Mexico City, Mexico. ff Soh Youn Suh, MD, Health Sciences Clinical Instructor of chip-scale MHz optical coherence Dr. Schwartz also presented the tomography. ­FloRetina Lecture “Stem Cell Therapy ff Soheab Ugradar, MD, Health for Maculopathies” on June 7, 2019, in Sciences Clinical Instructor Stacy L. Pineles, MD, Jerome and Joan Florence, Italy. Snyder Chair in Ophthalmology, received the University of California OptumLabs Bradley R. Straatsma, MD, JD, founding Research Credit Award from the UC chair of the UCLA Department of Oph- Regents in June 2018. thalmology and founding director of the Dr. Pineles was further honored with Stein Eye Institute, was the recipient of the American Association for Pedi- the 2018 Albert Nelson Marquis Lifetime atric Ophthalmology and Strabismus Achievement Award from Marquis Who’s (AAPOS) Young Investigator Award at the Who, Berkeley Heights, New Jersey. Steven A. Barnes, PhD Ava K. Bittner, OD, PhD AAPOS meeting on March 29, 2019, in Dr. Straatsma was also elected as an San Diego, California. honorary member of the International Society of Ocular Oncology during the Srinivas R. Sadda, MD, president and society’s meeting March 22–26, 2019, in chief scientific officer of the Doheny Eye Los Angeles, California. Institute, presented the keynote address “How Will Ocular Imaging Evolve in the David S. Williams, PhD, professor Next 20 Years” at the inaugural Asia-­ of ophthalmology and neurobiology, Pacific Ocular Imaging Society sym- received the Foundation Fighting Blind- Ram Kannan, PhD Soh Youn Suh, MD posium on March 7, 2019, in Bangkok, ness Visionary Award on November 17, Thailand. 2018, in Los Angeles, California. Dr. Williams was also identified as the top-rated expert in deaf-blind disorders in the world by Expertscape, a website dedicated to objective rankings of med- ical expertise. The June 2019 ranking is based on 606 articles published since 2009. Yuhua Zhang, PhD Soheab Ugradar, MD

8 UCLA STEIN EYE INSTITUTE | A Year in Review Milestones

Stein and Doheny Celebrate Five-Year Anniversary It was a first of its kind—and this year, the historic affiliation between the Stein Eye Institute and the Doheny Eye Institute marked its five-year anniversary. IN MEMORIAM The affiliation aligned each Institute’s strengths under the banner of the UCLA Department of Ophthalmology and achieved immediate bene- fits for patients, with the opening of Doheny Eye Center UCLA locations Patricia E. Bath, MD across the Southland. Unstoppable in their combined abilities, the work of Doheny and Stein Dr. Patricia Bath, the first female fac- Eye vision scientists and basic researchers is already leading to impactful ulty member in the UCLA Department discoveries and development of innovative eye care therapies. of Ophthalmology, died May 30, 2019, following complications from cancer. She was 76. Dr. Bath held a faculty appointment from 1974 to 1987, and she was chief of the Ophthalmology Division of what is now the Charles R. Drew University of Medicine and Science. She was director of the school’s ophthalmol- ogy residency training program. Dr. Bath is credited with inventing the Laserphaco probe, a device she patented in 1988 to improve cataract surgery. She also co-founded the non-profit American Institute for the Prevention of Blindness. The National Institute of Medicine recognized Dr. Bath’s contributions in their biogra- phy, Changing the Face of Medicine.

Dr. Bartly Mondino (left) and Dr. Bradley Straatsma (right) honor the achievements of their colleagues, Drs. Ralph Levinson (center left) and Sherwin Isenberg (center right).

Reception Honors Drs. Sherwin Isenberg and Ralph Levinson Celebrating more than 60 combined years as UCLA Department of Ophthalmology faculty, Sherwin J. Isenberg, MD, and Ralph D. Levinson, MD, were honored at a retirement reception at the Stein Eye Institute on May 8, 2019. Preventing neonatal and childhood blindness has been a mission of Dr. Isenberg’s for decades. The Laraine and David Gerber Chair in Ophthalmology and Distinguished Professor of Ophthalmology has developed methods to prevent pediatric vision loss from debilitating eye infections that impact more than 10,000 children a year in low- resource countries. Dr. Levinson, health sciences clinical professor of ophthalmology, has investigated the clinical aspects of uveitis and the immunogenetics of ocular inflammation. His research has resulted in identification of new genetic markers and deeper under- standing of the interrelationship of disease factors, as well as the course of disease and its response to treatment. Devoted clinicians, researchers, teachers, and mentors, Drs. Isenberg and Levinson have left an indelible mark on the Institute’s history and its future.

A Year in Review | UCLA STEIN EYE INSTITUTE 9 Education

Resident and Fellow Graduation and Award Ceremony Residents, fellows, and faculty were honored for excellence at the UCLA Department of Ophthalmology graduation on June 7, 2019:

Senior Honor Awards Betsy E. Blechman, MD Bryant J. Lum, MD Laurence N. Roer, MD Resident Research Award Victoria L. Tseng, MD, PhD Clinical Fellow Research Award Wei “Wayne” Gui, MD Members of the 2019 Graduating Class Research Fellow Research Award Wenlin Zhang, MD, PhD Predoctoral Fellow Research Award 24th Vision-Science Conference Joseph Park, MS The Vision-Science Conference, jointly sponsored by the UCLA Stein Eye Institute Postdoctoral Fellow Research Award and the National Eye Institute Vision Science Training Grant, celebrated its twenty­ Michel Sun, MD, PhD fourth year October 12–14, 2018, at the UCLA Lake Arrowhead Conference Center. ARVO Young Investigator Travel Award Eighty attendees participated in discussions and educational activities. Marie Qing Wang, MD, PhD Burns, PhD, professor of ophthalmology and vision science, professor of cell biology Resident Weekly Quiz Award and human anatomy at the Center for Neuroscience, University of California, Davis, Cameron Pole, MD presented the keynote address. Awards were also presented for best oral presentations and best posters: Faculty Teaching Award Peter A. Quiros, MD Best Oral Presentations Best Posters Fellowship Faculty Teaching Award Ala Morshedian, PhD Alejandra Young, PhD Saba Al-Hashimi, MD Adrian Au, PhD Rikard Frederiksen, PhD Fellow Teaching Award Anna Matynia, PhD Nermin Kady, PhD Justin Karlin, MD Resident Teaching Award Kirk K. Hou, MD, PhD Resident Award for Medical Student Teaching Judd Cahoon, MD Elisha C. Garg, MD

Attendees at the 2018 Vision-Science Conference in Lake Arrowhead

10 UCLA STEIN EYE INSTITUTE | A Year in Review Aesthetic Eyelid and Facial Rejuvenation Course Practicing ophthalmologists and sur- gical specialists from across the world attended the two-day Aesthetic Eyelid and Facial Rejuvenation Course at the UCLA Stein Eye Institute July 20–21, 2018. A dissection workshop on the first day provided participants with hands-on experience performing eyelid and facial procedures that utilized the most advanced techniques. A symposium on the second day covered a wide range of aesthetic surgery topics and included live demonstrations. Also presented was the Robert Axelrod, MD, Memorial Lecture by George C. Charonis, MD, PhD, director, Department of Orbital Surgery, Athens Vision Eye Institute, Athens, Greece. Robert Alan Goldberg, MD, chief of the Orbital and Ophthalmic Plas- tic Surgery Division, was the program chair. Course directors were Drs. Daniel Rootman, Norman Shorr, and Jonathan Hoenig. Students learn each Training in Basic and Advanced step of cataract Cataract Surgery surgery through hands-on courses. Kevin M. Miller, MD, chief of the Cataract and Refractive Surgery Division, organized two cataract surgery courses for Southern California ophthalmology trainees, which included instruction by many members of the UCLA faculty. The Alcon Laboratories Basic Cataract Surgery Course on November 17, 2018, included all steps of cataract surgery from incision construction through postoperative instructions. Skills-transfer laboratories provided attendees with hands-on experience in phacoemulsification, phacodynamics, ocular biometry, corneal topography, intraocular lens power calcu- lation, capsulorrhexis, ophthalmic viscosurgical devices, lens loading, toric lens implantation, and laser capsulotomy. From left to right: Drs. Raymond Douglas, Daniel Rootman, Robert Goldberg, The Johnson & Johnson Vision Advanced Cataract Surgery George Charonis, Norman Shorr, and course on June 1, 2019, provided instruction in anterior and Steven Leibowitz at the Aesthetic Eyelid and pars plana vitrectomy, femtosecond laser-assisted astigmatism Facial Rejuvenation Course. management, toric lens implantation, phaco machine settings, B scan ultrasonography, secondary lens implantation, glaucoma micro-stent implantation, small pupil management, Meibomian gland imaging, and extracapsular cataract extraction. Also included was a challenging cases video workshop.

A Year in Review | UCLA STEIN EYE INSTITUTE 11 Glaucoma Division Joint Retreat Stein and Doheny glaucoma faculty UCLA Department of Ophthalmology Clinical shared their clinical and basic-science and Research Seminar research projects with their colleagues and identified opportunities for collab- The Institute’s most prestigious educational event, the UCLA Department oration at a Glaucoma Division retreat of Ophthalmology Clinical and Research Seminar, was held June 7–8, on February 15, 2019, at the UCLA Fac- 2019, at the UCLA Stein Eye Institute. ulty Center. The seminar covered current clinical and research aspects of each Joint platforms, like this retreat, com- of the ophthalmic subspecialties, and included the full-time faculties of bine the strengths of each organization— the Stein Eye and Doheny Eye Institutes, along with nationally prominent leading to novel research, discovery, and speakers who presented the following keynote lectures: vision-protecting therapies. 50th JULES STEIN LECTURE David J. Wilson, MD Annual Comprehensive Paul H. Casey Chair Ophthalmology Review Department of Ophthalmology Course Director, Casey Eye Institute The Comprehensive Ophthalmology Oregon Health & Science University Review Course on February 21–14, 2019, at the UCLA Stein Eye Institute, reviewed 50th DOHENY MEMORIAL LECTURE the clinical essentials of each subspe- Paul P. Lee, MD, JD cialty in ophthalmology. The course was F. Bruce Fralick Professor & Chair clinically oriented, with review concen- Department of Ophthalmology & Visual Sciences trating on the epidemiology, clinical pre- University of Michigan sentation, diagnosis, and management Director, W.K. Kellogg Eye Center of ophthalmologic disease to prepare attendees for upcoming ophthalmology 17th BRADLEY R. STRAATSMA LECTURE examinations and required continuing Jeffrey L. Goldberg, MD, PhD medical education recertification. Professor & Chair of Ophthalmology Directed by Drs. John A. Irvine and Byers Eye Institute at Stanford University Sherwin J. Isenberg, the four-day inten- sive review course is held annually by 17th THOMAS H. PETTIT LECTURE the UCLA Stein Eye and Doheny Eye Yvonne Ou, MD Institutes. UCLA course faculty contribut- Associate Professor of Ophthalmology ing to the 2019 program were Drs. Saba Vice Chair for Postgraduate Education Al-Hashimi, Bruce B. Becker, Benjamin Co-Director, Glaucoma Service B. Bert, Hugo Y. Hsu, Michael S. Ip, Department of Ophthalmology Monica R. Khitri, Olivia L. Lee, Colin A. University of California, San Francisco McCannel, Tara A. McCannel, Kevin M. Miller, Daniel B. Rootman, SriniVas R. Sadda, David Sarraf, James C. H. Tan, and Federico G. Velez.

12 UCLA STEIN EYE INSTITUTE | A Year in Review Charting a Path Toward Pacific Retina Club Better Measures for The Pacific Retina Club presented its New Uveitis Treatments 7th annual meeting on March 15, 2019, At the March 22–23, 2019, UCLA/Amer- at the California NanoSystems Institute ican Uveitis Society workshop, approxi- at UCLA. Participants presented their mately 100 participants from 14 countries most interesting case of the year, which created a foundation for optimizing the was then followed by lively and insightful emergence of optical coherence tomog- group discussion. Course directors were raphy, other imaging techniques, and arti- Drs. H. Richard McDonald, SriniVas R. ficial intelligence to obtain more precise Sadda, and David Sarraf. measurements of the inflammation that characterizes uveitis. International Retinal Imaging Participants agreed that use of more Symposium objective measures of inflammation is a The International Retinal Imaging Sympo- goal to pursue, and that working groups sium (IntRIS) was held on March 16, 2019, should move forward with the ideas at the California NanoSystems Institute that came out of the meeting. Organiz- at UCLA. More than 55 world-renowned ers were Gary N. Holland, MD, Jack experts discussed new technologies and H. Skirball Chair in Ocular Inflammatory applications of retinal imaging, providing Diseases, and director of the Institute’s insight and understanding in retinal imag- Ocular Inflammatory Disease Center, ing and showcasing the integral impor- SriniVas R. Sadda, MD, president and tance of innovative retinal imaging in the chief scientific officer of the Doheny Eye evaluation and management of retinal Institute and a leading authority on imag- disease. Course directors were Drs. K. ing research, and Russell N. Van Gelder, Bailey Freund, SriniVas R. Sadda, and MD, PhD, trustee of the American Uveitis David Sarraf. Society. The event was co-sponsored by the UCLA Stein Eye Institute, the Gaining Subspecialty Doheny Eye Institute, and the American Uveitis Society. Knowledge Study group meetings were held through- Inherited Retinal Dystrophies: out the academic year and are an integral A Comprehensive Summit part of the UCLA Department of Ophthal- mology residency and clinical fellowship The UCLA Department of Ophthalmology training programs. The study groups also collaborated with the Scientific Office of serve as an informal resource for practic- the Embassy of France in the USA and ing ophthalmologists in the community. the Institut de la Vision in Paris, France, Conference topics include: cornea, and organized a Comprehensive Summit glaucoma, neuro-ophthalmology, oph- on Inherited Retinal Dystrophies (IRDs) at thalmic pathology, pediatric ophthalmol- the Stein Eye Institute on May 6, 2019. ogy and strabismus, pediatric rheuma- Vision scientists from the Stein Eye tology and uveitis, and retinal imaging. and Doheny Eye Institutes participated in sessions with researchers from France and the USA, and start-up companies from both countries. The one-of-a-kind meeting presented a comprehensive approach to IRDs, from their epidemiology to innovative treatments, with the goal of increasing collaboration and facilitating the trans- lation of basic research into application.

A Year in Review | UCLA STEIN EYE INSTITUTE 13 Community Outreach

Access to a Cure is Access to Care The Stein Eye Institute’s UCLA Mobile Eye Clinic (UMEC) program, directed by Anne L. Coleman, MD, PhD, served 9,675 children and adults this year, diag- nosed 1,403 ocular abnormalities, and made 410 trips throughout Los Angeles County to bring access to eye care for those who need it the most. In addition, the new partnership with UCLA Health and the LA Dodgers resulted in UMEC providing free eye health screenings for patrons at seven LA Dodgers RBI community events and home games this season. Other Stein Eye Institute’s community outreach activities included the following:

Adult Vision Program Through the Adult Vision Program, 705 free eye exams were given to individuals lacking access to adequate vision care due to reasons such as cost, transpor- This year UMEC added a second bus to its fleet. The 40-foot-long bus runs on environmentally friendly natural gas and contains one pre-examination room, two examination rooms, a computer- tation, and insurance. networking infrastructure, and a security camera system. The program provided 104 adult ­community-outreach events at home- less shelters, libraries, federally qualified Care Harbor 2018 health centers, and other nonprofits in Continuing its annual tradition, UMEC the Los Angeles County area. participated in Care Harbor Los Angeles, October 13–15, 2018, where thousands of the community’s most vulnerable UCLA MOBILE patients received free medical, dental, EYE CLINIC vision, and preventive care conserva- tively valued at $2,110,000. Attended At the three-day event, 14 ophthalmol- ogists and over 20 nurses, technicians, and support staff volunteered their time

19 and evaluated 196 patients. Compre- HEALTH FAIRS hensive dilated exams were given to served patients at risk for eye disease, which would include a history of diabetes or 907 hypertension, a family history of glau- PATIENTS coma, or decreased vision not corrected with eyeglasses, and 99 patients were and gave referred to community eye specialists for further evaluation and treatment, which 223 is often given free of charge. REFERRALS TO INDIVIDUALS WHO NEEDED FOLLOW-UP CARE

14 UCLA STEIN EYE INSTITUTE | A Year in Review UCLA Undergraduate Student Clubs Dr. Coleman is also the faculty advi- sor for the UCLA undergraduate club, Bruin Vision Project (BVP). Since 2008, BVP has been dedicated to providing access to eye care for uninsured com- munities and vulnerable populations in Los ­Angeles. As one of the only organi- zations at UCLA that focuses on provid- ing vision care services for the under- served, BVP works in partnership with the UCLA Stein Eye Institute and UMEC to provide vision-screening services and additional resources at health fairs across Los Angeles County. We are also proud to announce the new UMEC Student Leadership Club UCLA HEALTH GOES DODGER BLUE! (UMEC SLC) founded by UMEC under- As part of the new partnership between UCLA Health and the Los Angeles Dodgers, the graduate volunteers in fall 2018 to assist UCLA Mobile Eye Clinic provides vision care at home games. (L to R): UCLA leadership UMEC with providing free vision care to Dr. John Mazziotta, Dr. Robert Cherry, and Johnese Spisso (far right) with Dodgers’ Manager, Dave Roberts. underserved Angelinos. The club aims to shape members into future leaders through clinical exposure and profes- sional development. In less than a year PRESCHOOL of existence, the club won the presti- gious UCLA Mongelli Award for Excel- VISION PROGRAM lence in Civic Engagement and over $2,700 in UCLA grants to fund clinical The UCLA Preschool Vision Program offers no-cost services for supplies and much needed transporta- underserved preschoolers in the Los Angeles area. tion of volunteers to UMEC clinics. Volun- This year the program provided: teers are now able to participate in more clinics across Los Angeles County— from Pomona to Palmdale—so they can 7,305 assist with set-up, check-ins, and patient VISION SCREENINGS flow. Through their work with UMEC, the UMEC SLC has had a significant impact on the community. To learn more about 774 UMEC SLC, go to https://uclahs.fyi/SLC FULLY DILATED EYE EXAMS

Learn More at the UMEC Website Privately funded, UMEC has been provid- 782 ing free eye care services and glasses PAIRS OF GLASSES for underserved communities in Los and provided Angeles County for over 40 years and has been honored for exemplary leader- ship in shaping the future of health care. Find more information and/or how to 129 REFERRALS TO PARTNER SPECIALISTS get involved by volunteering or donating FOR PRESCHOOL STUDENTS NEEDING at: www.uclahealth.org/umec. SPECIALIZED MEDICAL OR SURGICAL TREATMENTS

A Year in Review | UCLA STEIN EYE INSTITUTE 15 Alumni News

Drs. Bateman and Straatsma Honored for Global Leadership J. Bronwyn Bateman, MD, UCLA Depart- ment of Ophthalmology clinical professor and alumna, and Bradley R. Straatsma, MD, JD, founding chair of the Depart- ment and founding director of the Stein Eye Institute, were jointly honored with the A. Edward Maumenee Medal for Distinguished Service at the 34th Pan-­ American Association of Ophthalmology (PAAO) Congress on May 25, 2019, in Cancún, Mexico. Stein and Doheny Host Both Drs. Bateman and Straatsma Joint Alumni Reception have served as president of the PAAO, and the award honors their exemplary Alumni from the Stein and Doheny Dr. David Aizuss service for continuing education for oph- Eye Institutes gathered at the President of the California thalmologists, the prevention of blind- Westin Chicago River North in Chi- Medical Association ness, and the promotion of scientific and cago, Illinois, on October 28, 2018, for a fun evening reconnecting with David H. Aizuss, MD, UCLA Department cultural exchange among ophthalmolo- friends, colleagues, and mentors. of Ophthalmology resident and fellow gists in the Western Hemisphere. The joint reception—held annu- alumnus (1981–1985) and assistant clin- ally during the American Academy ical professor of ophthalmology, was Valentina Franco-Cardenas, MD, has of Ophthalmology meeting—was installed as the 151st president of the been named to the Pan-American Asso- hosted by the UCLA Stein Eye Insti- California Medical Association (CMA) ciation of Ophthalmology (PAAO) 2019– tute Alumni Association and the during the organization’s annual House 2021 Executive Committee, where she Doheny Eye Institute Professional of Delegates (HOD) meeting on October will serve as Associate Secretary, Span- Alumni Association. Find photos 13, 2018, in Sacramento, California. ish Language Region. Dr. Cardenas was and information at: www.facebook. Dr. Aizuss is the first ophthalmologist­ an international research and clinical com/JSEIAlumni. only president of the CMA in more than fellow in retina at the Stein Eye Institute 50 years. He has been a CMA and Los in 2010–2011. She is currently in private Angeles County Medical Association practice and associated with top medical (LACMA) member for 37 years. He has institutions in Mexico City, Mexico. been a member of the CMA Board of Trustees since 2010—serving as vice­ chair and chair of the board before being named president-elect at the 2017 HOD. Dr. Aizuss has also represented the phy- sicians of California as a delegate to the American Medical Association (AMA), and he is currently serving on the AMA Council on Legislation. Dr. Aizuss is a former president of LACMA and the Cal- ifornia Academy of Eye Physicians and Surgeons. He is a partner at Ophthalmol- ogy Associates of the Valley.

Dr. J. Fernando Arevalo (left), president of the Pan-American Association of Ophthalmology, presents the A. Edward Maumenee Medal for Distinguished Service to co-recipients Dr. J. Bronwyn Bateman and Dr. Bradley Straatsma at the PAAO Congress in Cancún, Mexico.

16 UCLA STEIN EYE INSTITUTE | A Year in Review Dr. Bartly Mondino (center), chair of the UCLA Department of Ophthalmology and director of the Stein Eye Institute, with Dr. Bartly Mondino (center) visits with Department faculty members Ms. Marissa Goldberg, executive director and chief financial officer of Dr. Sophie Deng (left) and Dr. Anne Coleman (right). the Doheny Eye Institute, and Dr. SriniVas Sadda, president and chief scientific officer of the Doheny Eye Institute.

Drs. Federico Badalà, JoAnn Giaconi, Alessandro Rabiolo, and Joseph Caprioli reconnect at the alumni event.

(L to R): Drs. Julian Perry, Tina Rutar, and Catherine Hwang join Dr. Bradley Straatsma, founding chair of the UCLA Department of Ophthalmology and founding director of the Stein Eye Institute.

Enjoying the reception are (L to R) Drs. Simon Law, Frank La Rosa, Mark Kramar, Annette Giangiacomo, Joseph Caprioli, and Lucy Shen.

(L to R): Drs. Robert Goldberg, Bartly Mondino, Sophie Deng, and Tara McCannel welcome alumnus resident Dr. Shawn Lin (center).

A Year in Review | UCLA STEIN EYE INSTITUTE 17 Jules and Doris Stein UCLA Support Group

Volunteer Committee may borrow the voice-activated assistive Shares the Gift of Sight devices for an indefinite period of time. VISION IN The Preschool Vision Screening pro- SCHOOLS The Jules and Doris Stein UCLA Support gram began 20 years ago under the Group Volunteer Committee, the volun- supervision of the late Dr. Leonard Apt, teer arm of the Stein Eye Institute estab- founding chief of the Division of Pediatric lished in 1990, accomplished impressive Ophthalmology and Strabismus. During 33 community outreach results this fiscal the 2018 school year, 24 Volunteer Com- VOLUNTEERS year—results that would not have been mittee volunteers visited 17 classrooms visited possible without the commitment of to screen 374 children between three generous members and donors and the and five years of age. dedication of over 126 volunteers. The Shared Vision program collected 34 CLASSROOMS The Vision IN-School (VIS) educa- and recycled approximately 3,500 tion program is offered free of charge donated eyeglasses for those in need. and taught to fourth- through seventh-grade public Recycled eyeglasses were cleaned, school students in Los Angeles. Students tagged with the vision correction, and are taught about the anatomy of the eye, 1,082 distributed to Los Angeles homeless STUDENTS ABOUT eye safety, and injury prevention. The shelters, as well as clinic missions con- THE EYE highlight of each in-class presentation is ducted by nonprofit groups in Southeast a hands-on dissection of a bovine eye. Asia, Central America, and other low-­ Thirty-three VIS volunteers visited 34 resource regions. classrooms this past year, presenting the Team Stein Eye participated in the curriculum to 1,082 elementary students. twelfth annual Los Angeles Founda- SHARED A successful year-end sponsorship tion Fighting Blindness Vision Walk, VISION drive was held for the Make Surgery which was held at Crescent Bay Park Bearable program, an initiative that pro- on October 27, 2018. The event, sup- Collected and vides Dr. Teddy bears to each pediatric ported by both Stein Eye employees recycled patient undergoing eye surgery at Stein and volunteers from the Jules and Doris Eye. Pediatric patients also receive an Stein UCLA Support Group’s Volunteer informational children’s book, Making 3,500 Committee, raised funds for retinal eye PAIRS OF GLASSES Eye Surgery Bearable, that helps young disease research. patients and their caregivers prepare for FOR THOSE IN NEED surgery. Offered in both Spanish and English, the book was written at the sug- gestion of the Pediatric Ophthalmology and Strabismus Division. PRESCHOOL Both the book and the cuddly teddy bear, dressed in green scrubs and tagged SCREENING with the name of the donor, help chil- dren feel comforted and secure during what could otherwise be a frightening 24 time. UCLA Bruin Belle volunteers joined VOLUNTEERS forces with the Volunteer Committee to visited help tag the bears and books. The MagniVision program provides financial support for the UCLA Vision 17 CLASSROOMS Rehabilitation Center (VRC), which enables the purchase of low-vision tools and screened for the VRC lending library. This year, under the direction of Volunteer Com- 374 mittee Advisory Board Member Robin CHILDREN FOR Carnesale, the Committee purchased VISION ISSUES additional Kindle Fire devices to add to the lending library. Low-vision patients

18 UCLA STEIN EYE INSTITUTE | A Year in Review Philanthropy Bert O. Levy Endowed Chair in Endowed Chairs Pay Tribute to Both Donor and Holder Orbital and Ophthalmic Plastic Surgery his academic year, the Stein Eye Institute celebrated the inaugural appoint- Robert Alan Goldberg, MD, chief of the ments of three faculty members to endowed chairs that were established by Orbital and Ophthalmic Plastic Surgery donors to further support Stein Eye’s research, patient care, education, and T Division, was appointed as the inaugural outreach activities. Each chair pays tribute to both the distinguished faculty member chair holder of the Bert O. Levy Endowed who holds the chair and the generous donor who has embraced the vision of a clear Chair in Orbital and Ophthalmic Plastic and brighter tomorrow for countless patients. “We are indebted and gratified by our Surgery. The reception on June 18, 2019, supporters’ tremendous commitment to and belief in Stein Eye and the work we do,” also celebrated philanthropist and long- says Bartly J. Mondino, MD, director of the Stein Eye Institute, chairman of the UCLA time friend of Stein Eye Mr. Bert O. Levy, Department of Ophthalmology, and affiliation chairman of the Doheny Eye Institute. whose gift will fund Dr. Goldberg’s efforts to advance research, patient care, and Smotrich Family Optometric education. Within his subspecialty, Dr. Clinician-Scientist Chair Goldberg is the primary faculty mentor for medical students, residents, physi- Ava K. Bittner, OD, PhD, was appointed cians, and clinical and international fel- the inaugural chair holder of the Smotrich lows, and is unstinting in his efforts to pro- Family Optometric Clinician-Scientist vide superior instruction and guidance. Chair at a reception on May 15, 2019. Dr. Goldberg has authored more than Dedicated optometrists and ophthalmol- 250 peer-reviewed papers, 64 books ogists helped raise funds for the chair, and book chapters, and is on the editorial named in honor of Marvin Smotrich, OD, board for prestigious journals. a UCLA alumnus and an accomplished optometrist who served on the original Dr. William Stivelman, chief executive officer and medical director of the Mary Oakley chair campaign committee and played an Foundation (left) and Dr. Bartly Mondino integral role in bringing the chair to frui- (center) join Dr. Anthony Arnold, the recipient tion. Dedicated exclusively to an optom- of the Mary Oakley Chair, at a reception at the Stein Eye Institute on October 17, 2018. etrist, the chair will help bridge the gap between optometrists and ophthalmol- ogists, and therefore be unique in aca- Mary Oakley Foundation Chair in demic ophthalmology. Funding will help Neurodegenerative Diseases further the development of broad-based Anthony C. Arnold, MD, chief of the research among the two professions and Neuro­-Ophthalmology Division at Stein encourage the continuation of many of Eye, was celebrated as the inaugural the advances in bilateral professional Dr. Bartly Mondino (left) presented Mr. Bert recipient of the Mary Oakley Foundation cooperation in research, education, and Levy (center) and Dr. Robert Goldberg with Chair in Neurodegenerative Diseases at public service. commemorative chair trophies. a reception at the Stein Eye Institute on October 17, 2018. William C. Stivelman, MD, chief executive officer and medical director of the Mary Oakley Foundation, facilitated the chair’s endowment, which will support academic research activities in the area of neurodegeneration. Neu- rodegenerative diseases represent a large group of neurological disorders, with Alzheimer’s Disease being one of the most common. The most consistent risk factor for developing a neurode- generative disease is increasing age, and with an expanding population of people over the age of 65, research in this field is critical. Attendees of the May 15 reception included (left to right) Drs. Bradley Straatsma, Bartly Mondino, Marvin Smotrich, Jule Lamm, and Ava Bittner.

20 UCLA STEIN EYE INSTITUTE | Philanthropy WithGratitude

or more than half a century, countless loyal friends and donors have generously contributed to uphold the mission of the UCLA FStein Eye Institute in the noble effort to preserve sight and restore vision. This dedication has had an invaluable impact on ophthalmology and related dis- ciplines locally, nationally, and abroad. We embrace the future strides we—and the next generation of eye specialists and vital supporters—will make to advance this meaningful and influential medical and scientific field.

Major Gifts $25,000 and Above: Peter and Helen Bing Laura E. Fox, MD Anonymous Research to Prevent Blindness, Inc. Marcia and Jeffrey Lloyd Bert O. Levy Ruth and George E. Moss Michael B. Gorin, MD, PhD Bradley R. Straatsma, MD, JD The Benjamin H. Williams Trust Patricia Tussing Bruce Ford and Anne Smith Bundy The Carl and Roberta Deutsch Simon K. Law, MD, PharmD Foundation Foundation Stacy Pineles, MD Carmichael Family Trust The Foundation Fighting Blindness Steven D. Schwartz, MD Carol and Timothy W. Hannemann The Jules and Doris Stein UCLA Support Group IN MEMORY OF: Dr. Tanuj Nakra and Mrs. Nidhi Nakra The Karl Kirchgessner Foundation Anne M. Bodenheimer Dr. Tomoyuki Kashima The Simms/Mann Family Foundation Brother Leonard Reeson Elaine L. Ellsworth Revocable Living Trust The Vision of Children Foundation, David D. Porter Sam and Vivian Hardage Elaine Sarkaria Donald M. Fetherolf The William & Margaret Fern Holmes Estate of Jean Stein Dr. Stanley Capper Family Foundation Fairchild-Martindale Foundation Elena Curris Theo and Wendy Kolokotrones Hess Foundation, Inc. Gordon Cunningham Wilbur May Foundation Hongbin Peng Henry I. Baylis, MD J. Bronwyn Bateman, MD Individuals Recognized Herbert J. Grossman, MD Jerome and Joan Snyder with a Tribute Gift Howard D. Felsher Joan A. Payden and William R. Payden J. Patrick Busch IN HONOR OF: John So Min S. Chang, MD Jerome S. Field Allan E. Kreiger, MD Karen and Franklin Dabby Linda Lou Papaleo and Arthur L. Rosenbaum, MD Elaine L. Ellsworth Knights Templar Eye Foundation, Inc. Bradley R. Straatsma, MD, JD Manuel A. Sison, MD Lavery Foundation Jean-Pierre Hubschman, MD Mary Ruth Chaney Skandera Leonard Apt Trust Joseph Caprioli, MD Muriel L. Gach Lila Hartman Living Trust Joseph L. Demer, MD, PhD Pamela Fumo Memorial Scholarship Foundation to Mr. Lin Hsiung-Chen Jule D. Lamm, OD Peggy L. Giambrocco Mr. and Mrs. Robert Knutson Kamal A. Zakka, MD Roland Davies Mr. and Ms. Jacques Lejeune Karrie and Jeff Fann Russell W. Neuhaus, MD Mr. and Ms. Thomas W. Austin Kevin M. Miller, MD Stanley K. Rothstein Muranaka Family L. Scott Feiler, MD

Philanthropy | UCLA STEIN EYE INSTITUTE 21 Stein Eye Institute Endowed David May II Chair in Ophthalmology Jack H. Skirball Chair in Ocular Chairs Supporting Department Established in 1998 as a term- Inflammatory Diseases of Ophthalmology Faculty appointment chair by the family of Initiated in 2008 by The Skirball Mr. David May II, a founding member Foundation in honor of Mr. Jack H. Arthur L. Rosenbaum, MD, Chair in of the Institute’s Board of Trustees, to Skirball’s long-standing friendship Pediatric Ophthalmology perpetuate, in memoriam, Mr. May’s with Dr. Jules Stein and Mr. Lew Wasserman. Established in 2007 by Mr. and association with the Stein Eye Mrs. Gottlieb as an administrative Institute; after an additional pledge Gary N. Holland, MD chair for the Division of Pediatric from the Wilbur May Foundation, 2009–Present Ophthalmology and Strabismus it was converted to a permanent- in honor of the late Dr. Arthur L. appointment chair in 2009. Jerome and Joan Snyder Chair in Ophthalmology Rosenbaum. The chair was originally Gary N. Holland, MD named the Brindell and Milton Gottlieb 1999–2004 Established in 2008 by Mr. and Mrs. Chair in Pediatric Ophthalmology. Snyder to support the activities of a Joseph Caprioli, MD distinguished faculty member who Arthur L. Rosenbaum, MD 2004–Present directs the ophthalmology residency 2008–June 2010 Dolly Green Chair of Ophthalmology program, ensuring that UCLA’s Joseph L. Demer, MD, PhD accredited program continues to Established in 1980 by Ms. Dorothy 2015–Present offer rigorous and comprehensive (Dolly) Green. instruction for individuals of the Bert O. Levy Endowed Chair in Orbital Dean Bok, PhD highest caliber. and Ophthalmic Plastic Surgery 1984–2013 Anthony C. Arnold, MD Established in 2019 as a permanent- 2008–2017 appointment chair by Mr. Bert Levy Ernest G. Herman Chair in to support the teaching and research Ophthalmology Stacy L. Pineles, MD activities of an outstanding, academic Established in 2008 by Mr. Ernest G. 2017–Present orbital and ophthalmic plastic surgeon. Herman to support a vision scientist or a clinician-investigator. Joan and Jerome Snyder Chair in Robert A. Goldberg, MD Cornea Diseases 2019–Present Xian-Jie Yang, PhD Established in 2013 by Mr. and Mrs. 2012–Present Bradley R. Straatsma, MD, Endowed Snyder to support the activities of a Chair in Ophthalmology Grace and Walter Lantz Endowed distinguished faculty member in the area of corneal diseases and research. Established in 1994 to honor founding Chair in Ophthalmology director of the Stein Eye Institute, Established in 1991 as a term- Sophie X. Deng, MD, PhD* Bradley R. Straatsma, MD, JD. appointment chair by Mr. and Mrs. 2019–Present Bartly J. Mondino, MD Lantz and, with an additional pledge, it was converted to a permanent- Joan and Jerome Snyder Chair in 2000–Present Vision Science appointment chair in 2010. Established In 2018, this term chair Charles Kenneth Feldman Chair in J. Bronwyn Bateman, MD Ophthalmology will support the teaching and research Grace and Walter Lantz Scholar activities of an excellent scientist and Established in 1982 by various donors 1993–1995 faculty member in the Vision-Science in memory of Charles Kenneth Sherwin J. Isenberg, MD Division. Feldman, an entertainment industry Grace and Walter Lantz Scholar executive. 1993–1995 Jules Stein Chair in Ophthalmology Robert D. Yee, MD Professor 1996–2004 Established in 1982 as a memorial Professor 1984–1987 tribute to Dr. Jules Stein by his Joseph L. Demer, MD, PhD many friends, with the leadership of Hillel Lewis, MD Professor 2004–2005 Scholar 1989–1993 Mr. Samuel Goldwyn, Jr. Harold and Pauline Price Chair in Gabriel H. Travis, MD Wayne L. Hubbell, PhD Ophthalmology 2001–Present 1983–Present Established in 2000 by the Louis and Harold Price Foundation and, with an additional pledge, it was converted to a permanent-appointment chair in 2006. Michael B. Gorin, MD, PhD 2006–Present

22 UCLA STEIN EYE INSTITUTE | Philanthropy Karen and Frank Dabby Endowed Mary Oakley Foundation Chair in The Fran and Ray Stark Foundation Chair in Ophthalmology Neurodegenerative Diseases Chair in Ophthalmology Established in 2007 by Dr. and Mrs. Established in 2013 by The Mary Established in 1992 as a term- Dabby as a term chair to support the Oakley Foundation to support appointment chair by the Fran activities of a distinguished faculty neurodegenerative diseases. and Ray Stark Foundation, and member in the area of orbital disease. with an additional commitment, it Anthony C. Arnold, MD was converted to a permanent- Robert Alan Goldberg, MD 2017–Present appointment chair in 2009. 2008–2018 Oppenheimer Brothers Chair Joseph Caprioli, MD Daniel B. Rootman, MD, MS* Established in 2002 as a term chair 1997–2004 2019–Present by the Oppenheimer Brothers Anne L. Coleman, MD, PhD Foundation. Karl Kirchgessner Foundation Chair in 2004–Present Vision Science Joseph Horwitz, PhD Established in 2001 as a term- 2003–2017 The Wasserman Professor of appointment chair by a colleague Ophthalmology Suraj P. Bhat, PhD* of Dr. Jules Stein to promote basic- Established in 1977 by Edie and Lew 2019–Present science research initiatives. Wasserman to honor Dr. Jules Stein. Debora B. Farber, PhD, DPhhc Rory Smith, M.D. and Family Manfred Spitznas, MD 2001–2018 Endowed Chair 1979–1981 Established in 2019 by faculty alumna David S. Williams, PhD* Bartly J. Mondino, MD Dr. J. Bronwyn Bateman in honor 2019–Present Scholar 1984–1988 of her late husband, Dr. Roderick Professor 1988–2000 Kolokotrones Chair in Ophthalmology “Rory” Smith. Ben J. Glasgow, MD Established in 2004 by Wendy and Smotrich Family Optometric 2003–Present Theo Kolokotrones to support the Clinician-Scientist Chair teaching and research of a cataract Established in 2016 to support an Vernon O. Underwood Family surgeon and scientist. Chair in Ophthalmology optometric clinician-scientist at the Kevin M. Miller, MD UCLA Stein Eye Institute and will Established in 1995 as a term- 2005–Present fund the appointee’s education and appointment chair by Mrs. Adrienne research programs. Underwood Pingree in memory of Laraine and David Gerber Chair in her late husband, Mr. Vernon O. Ava K. Bittner, OD, PhD Ophthalmology Underwood. 2019–Present Established in 1998 as a term- John R. Heckenlively, MD appointment chair by Mr. and Mrs. The Ahmanson Chair in 1997–2004 Gerber and, with an additional Ophthalmology pledge, converted to a permanent- Gary N. Holland, MD Established in 2006 by The Ahmanson appointment chair in 2009. 2004–2009 Foundation as an administrative chair Joseph L. Demer, MD, PhD for the Retina Division Chief to further Lynn K. Gordon, MD, PhD 2000–2004 research, education, and clinical 2012–Present care programs. Sherwin J. Isenberg, MD Walton Li Chair in Cornea and Uveitis 2004–Present Steven D. Schwartz, MD Established in 2013 by Walton W. Li, 2007–Present Leonard Apt Endowed Chair in MD, as an administrative chair for the Pediatric Ophthalmology Cornea and Uveitis Division to further research and teaching activities. Established in 2004 by Professor Emeritus of Ophthalmology and Anthony J. Aldave, MD Founding Director of the Division 2014–Present of Pediatric Ophthalmology and Strabismus, Dr. Leonard Apt, with a gift from the trust of Frederic G. Rappaport, Dr. Apt’s nephew. Joseph L. Demer, MD, PhD 2005–2015

Philanthropy | UCLA STEIN EYE INSTITUTE 23 Doheny Eye Institute Endowed Stein Eye Institute Fellowship David May II Fellowship Fund Chairs Supporting Department Funds and Endowments Established in 1992 by the family of of Ophthalmology Faculty Mr. David May II to support advanced Abe Meyer Memorial Fellowship Fund study and research in ophthalmology A. Ray Irvine, Jr. MD, Chair in Established in 1969 by various and vision science. Clinical Ophthalmology donors to support clinical fellows at Christine Petersen, MD John A. Irvine, MD the Institute. 2018–2019 2014–Present Jonathan Young, MD, PhD Dr. Jack Rubin Memorial Fellowship 2018–2019 Charles Stewart Warren and Established in 1987 by the family of Hildegard Warren Endowed Adelaide Stein Miller Dr. Jack Rubin to support postdoctoral Research Chair Research Fellowship fellows. Vikas Chopra, MD Established in 1977 by Mr. Charles 2017–present Miller as a tribute to his wife, Adelaide Elsa and Louis Kelton Fellowship Stein Miller, Dr. Jules Stein’s sister. Endowed by the Keltons in 1982 to Flora L. Thornton Endowed Chair in support postdoctoral research and Giovanni H. Greaves, MD Vision Research training. 2018–2019 Alfredo A. Sadun, MD, PhD Nathan Abraham, MD 2014–Present Audrey and Jack Skirball Ocular 2018–2019 Inflammatory Disease Fellowship Gavin S. Herbert Endowed Chair for Established in 2011 by The Skirball Frances Howard Goldwyn Fellowship Macular Degeneration Foundation to support the training Established in 1977 by Mr. Samuel Michael Ip, MD of fellows specializing in ocular Goldwyn, Jr., with gifts from Mrs. 2019–Present inflammatory disease. Goldwyn’s estate and Dr. and Mrs. Jules Stein. Mary D. Allen Chair in Bert Levy Research Fellowship Fund Vision Research Christopher Lo, MD Established in 1995 by Mr. Bert 2018–2019 Deming Sun, MD Levy to enhance the educational 2015–Present opportunities of vision-science Frederic G. Rappaport Endowed scholars and advance research in Fellowship in Retina/Oncology Rupert and Gertrude I. Steiger neuro-ophthalmology. Vision Research Chair Established in 2004 by Mrs. Jeanne A. Rappaport as a memorial to her Cooperman Fellowship Fund Brian A. Francis, MD, MS son Frederic. 2015–Present Established in 1988 by the Coopermans to support eye research Jerome Comet Klein, MD, Stephen J. Ryan-Arnold and and education, with emphasis on Fellowship Fund Mabel Beckman Foundation clinical ophthalmology. Endowed Presidential Chair Established in 2007 by the Irving & Estelle Levy Foundation to provide David and Randi Fett Orbital SriniVas R. Sadda, MD fellowship and lecture support in the 2015–Present and Ophthalmic Plastic Surgery Fellowship Endowment areas of orbital and ophthalmic plastic surgery. Established in 2013 by Dr. David R. Fett and Ms. Randi Levine to support John and Theiline McCone fellows in the Orbital and Ophthalmic Fellowship Plastic Surgery Division. Established in 1989 by the McCones Justin Karlin, MD, MS to support and enhance education 2018–2019 programs and fellowship training in macular disease. Wei “Wayne” Gui, MD 2018–2019 Niranjan Manoharan, MD 2018–2019

24 UCLA STEIN EYE INSTITUTE | Philanthropy Jules Stein Research Fellowship The Harold and Pauline Price Established in 1982 by various donors Fellowship to honor the memory of Charles Established in 1987 by the Louis Kenneth Feldman. and Harold Price Foundation to support research and education in Lindsay M. De Andrade, MD ophthalmology and vision care. 2018–2019 Terry Wood, MD Jennifer Pan, MD 2018–2019 2018–2019 Thelma and William Brand Klara Spinks Fleming Fellowship Fund Director’s Fund Established in 1985 by Klara Spinks Established in 2004 with a trust from Fleming to support cataract research. Mr. William F. Brand to benefit worthy Nathan Abraham, MD students at the Stein Eye Institute. 2018–2019 The Mae and Lee Sherman Leonard Apt Endowed Fellowship in Fellowship Fund Pediatric Ophthalmology Established in 1981 by the Sherman Established in 2002 by founding chief family to support postdoctoral fellows. of the Pediatric Ophthalmology and Amir Marvasti, MD Strabismus Division, Leonard Apt, MD, 2018–2019 to support outstanding clinical fellows in the field of pediatric ophthalmology Wilbur D. May Fellowship and strabismus. Established in 2013 by the May family Leonard Apt, MD, Pediatric as a tribute to Mr. Wilbur D. May, the Fellowship Fund beloved uncle of Mr. David May II. Established in 2015 by the trust of Jason Mingyi Huang, MD Leonard Apt, MD, founding chief of 2018–2019 the Pediatric Ophthalmology and Strabismus Division, to support pediatric ophthalmology fellowships. Lindsay M. De Andrade, MD 2018–2019 Jennifer Pan, MD 2018–2019

Rosalind W. Alcott Fellowship Established in 1978 by the Rosalind W. Alcott Charitable Remainder Trust for the training of outstanding postdoctoral fellows. Nikisha A. Kothari, MD 2018–2019

Sanford and Erna Schulhofer Fellowship Fund Established in 1986 by Mr. Sanford Schulhofer to support postdoctoral research and training in vision science.

Philanthropy | UCLA STEIN EYE INSTITUTE 25 Endowments for Research, JSEI Maintenance Fund Education, and Patient Care Katherine L. Gardner Research Fund Louis and Annette Kaufman Fund Albert Sarnoff Endowed Cataract Fund Maggi Kelly Vision Fund Amalia Simon Roth Endowment Marie and Jerry Hornstein Family Anne H. West Estate Fund Endowed Macular Degeneration Anthony Eannelli Fund Research Fund Arna Saphier Macular Degeneration Michael Huffington Ophthalmology Fund Scholarship Fund Arthur Spitzer Fund Pat and Joe Yzurdiaga Audrey Hayden-Gradle Trust Endowed Cataract Fund Barbara P. Taylor Fund Patricia and Joseph Yzurdiaga Endowed Vision Science Bradley R. Straatsma Research Fund Research Fund Card Family Research Fund Patricia Pearl Morrison Research Fund Chesley Jack Mills Trust Paul J. Vicari Endowed Cataract Daniel B. Whipple Fund Research Fund Dr. William F. Stein and Esther Raymond and Ruth Stotter Elizabeth Stein Memorial Fund Vision Science Research Fund Edward and Hannah Carter Fund Richard B. Shapiro Vision Fund Elsie B. Ballantyne Regents Fund Sara Kolb Memorial Fund Elsie B. Ballantyne UCLA Foundation Stella F. Joseph Fund Fund The Annenberg Foundation Fund Emily G. Plumb Estate and Trust The Karl Kirchgessner Foundation Emma B. Gillespie Fund Ophthalmology Endowment Fund Endowment for Children with Uveitis The Leonard Apt, MD, Pediatric EyeSTAR Residency Training Fund Esther Shandler Research Fund The Leonard Apt, MD, Pediatric Gerald Oppenheimer Family Ophthalmology Fund Foundation Center for the Prevention of Eye Disease Endowment Fund The Skirball Foundation Fund Harold B. and Bernice L. Belfer Fund UCLA Center for Eye Epidemiology Henry I. Baylis, MD, Endowed Fund in Uncle Claude Fund Orbital and Ophthalmic Plastic Surgery Virginia Burns Oppenheimer Herb Ritts, Jr., Memorial Vision Fund Endowment Fund Herman King Fund Wickham Retina Research Fund Hintze Glaucoma Research Fund William R. Payden Fund for Glaucoma Research J. Richard Armstrong and Ardis Armstrong Fund William, Richard, & Roger Meyer Fund Jerome T. Pearlman, MD, Fund John and Theiline McCone Macular Disease Research Fund *pending

26 UCLA STEIN EYE INSTITUTE | Philanthropy Eye Health Programs Patient Care Services Stein Eye Institute The UCLA Stein Eye Institute is a Committed to advancing eye health, UCLA Department of Ophthalmology board- vision-science campus in Westwood certified faculty provide services ranging from routine eye examinations to the most that is home to state-of-the-art clinics, complex sight-saving procedures. laboratories, and an outpatient sur- The UCLA Stein Eye Institute and its affiliation partner, the Doheny Eye Institute, gical center equipped with the most are ranked among the top in the nation for ophthalmology. Patients and referring advanced tools for precision surgery. physicians alike trust UCLA Department of Ophthalmology faculty to provide the Direct consultation and treatment, highest level of care across every subspecialty, with premier services available at including emerging therapies, is the UCLA Stein Eye Institute vision-science campus in Westwood and at convenient available through the Ophthalmology neighborhood locales across the Southland. Faculty Consultation Service. Our faculty members have extensive, advanced training in ophthalmic sub- specialties and afford referring phy- COUNTY Olive View-UCLA Medical Center SYLMAR sicians and patients with a valuable resource for special eye problems. Additionally, wide-ranging and subspe-

LOS ANGELES cialty eye care in all medical and surgi- Doheny Eye Center UCLA cal areas of ophthalmology is offered VENTURA COUNTY PASADENA through the Comprehensive Ophthal- mology Division, which is staffed by UCLA Stein Eye Institute WESTWOOD members of the UCLA Medical Group. Doheny Eye Center UCLA ARCADIA The Institute’s outpatient surgical center, housed in the award-winning Edie & Lew Wasserman Building, sets Veterans Affairs Healthcare System the standard for excellence in patient Stein Eye Center UCLA WEST LOS ANGELES/ SANTA MONICA SEPULVEDA care and medical progress. Ophthalmic surgery of every kind—from cataract LOS ANGELES COUNTY extraction and laser vision-correction ORANGE COUNTY surgeries to removal of ocular tumors— is performed. Faculty members and Harbor-UCLA Medical Center TORRANCE skilled medical specialists, including subspecialty fellows, medical residents, anesthesiologists, nurses, and techni- cians, ensure that each patient receives the highest quality preoperative and Doheny Eye Center UCLA postoperative care possible. ORANGE COUNTY The Ophthalmology Inpatient Con- sultation Service, operating 24 hours a day through the Ronald Reagan UCLA Medical Center and UCLA Medical Center Santa Monica, provides oph- UCLA Department of Ophthalmology thalmic consultation and treatment to Los Angeles and Beyond pediatric and adult patients who are admitted to the medical centers for inpatient care. The consultation team consists of physician-residents at the UCLA Stein Eye Institute, with sub- specialty coverage provided by UCLA Department of Ophthalmology faculty.

Stein Eye Institute, Westwood Learn more about our 100 Stein Plaza, UCLA LOCATIONS, PROVIDERS, and Los Angeles, CA 90095 SERVICES at: Referral Service: (310) 825-5000 Emergency Service: (310) 825-3090 www.uclahealth.org/eye/ After-Hours Emergency Service: our-locations. (310) 825-2111

28 UCLA STEIN EYE INSTITUTE | Eye Health Programs Stein Eye Center Doheny Eye Center UCLA The Stein Eye Center–Santa Monica Convenient Doheny Eye Center The Doheny Eye Center UCLA– offers the world-renowned compre- UCLA locations across the Southland Orange County is located in the hensive and subspecialty eye care set the standard for excellence, with Orange Coast Memorial Medical Cen- of the UCLA Stein Eye Institute at a UCLA Department of Ophthalmology ter and broadens the reach of the UCLA convenient neighborhood location. faculty providing the finest clinical care, Department of Ophthalmology south to The Center features well-equipped surgical services, diagnostic testing, Orange County. examination rooms, an optical shop, and treatment available. The location offers comprehensive on-site parking for easy access, and The Doheny Eye Center UCLA– ophthalmology, as well as cornea, glau- testing facilities offering a wide range Arcadia serves patients in the broader coma, neuro-ophthalmology, pediatric of examinations, including visual field, Arcadia region and San Gabriel area, and uveitis subspecialty services, and corneal mapping (corneal topography), expanding the UCLA Department of retina. The Center includes 12 exam intraocular lens measurement, fluores- Ophthalmology’s reach in Los Angeles rooms, dedicated diagnostic equip- cein angiography, spectral domain opti- County. The renovated office includes ment, and comfortable patient areas. cal coherence tomography, and other 12 exam rooms, dedicated diagnostic diagnostic retinal imaging techniques. equipment, and attractive patient areas. Doheny Eye Center UCLA– Expert ophthalmologists at the Stein The Center provides comprehensive Orange County Eye Center–Santa Monica offer nearly ophthalmology, and nearly all subspe- Orange Coast Memorial all the subspecialty services, diag- cialty services, including cornea, glau- Medical Center nostic testing, and treatment services coma, and retina. 18111 Brookhurst St., Suite 6400 available at the Stein Eye Institute in The Center is easily accessible from Fountain Valley, CA 92708 Westwood. two freeways and provides free, on-site Telephone: (714) 963-1444 parking. Fax: (714) 963-1234 Stein Eye Center Santa Monica Doheny Eye Center UCLA 1807 Wilshire Blvd., Suite 203 Arcadia The Doheny Eye Center UCLA– Santa Monica, CA 90403 622 W. Duarte Rd., Suite 101 Pasadena serves as the primary hub of Telephone: (310) 829-0160 Arcadia, CA 91007 the Doheny Eye Center UCLA. Located Fax: (310) 829-0170 Telephone: (626) 254-9010 on the second floor of the Huntington Fax: (626) 254-9019 Pavilion, the Center provides expanded vision care services and clinics devoted to retina and cornea; comprehensive ophthalmology and oculoplastics; neuro-ophthalmology; and glaucoma. Each subspecialty clinic has dedicated, state-of-the-art diagnostic laser suites, as well as in-office procedure rooms. Complex procedures are performed at the Huntington Pavilion Surgical Suites, which are located on the building’s third floor. The Huntington Pavilion is home to a wide variety of medical practitioners, which provides physicians with ease of referral for patients requiring special- ized eye care and provides patients with the added convenience of seeing their doctors and having any necessary services all in one location.

Doheny Eye Center UCLA Pasadena Huntington Pavilion 625 S. Fair Oaks Blvd., 2nd Floor Pasadena, CA 91105 Telephone: (626) 817-4747 Fax: (626) 817-4748 A year after its opening, the Stein Eye Center–Santa Monica doubled in space to meet patient demand.

Eye Health Programs | UCLA STEIN EYE INSTITUTE 29 Centers and Laboratories

Research and Treatment Centers The Research and Treatment Centers provide subspecialty care from faculty physicians who are actively involved in related research, enabling emerging and experimental treatment options to be developed for a gamut of eye dis- orders. In addition to comprehensive treatment, the centers provide both UCLA Department of Ophthalmology patients and physicians with expert Summary of Patient Care Statistics diagnostic and consultation services for diseases that are difficult to iden- tify and treat. Ophthalmology faculty work closely with other specialists, 2017–2018 2018–2019 both within the Stein Eye Institute and in other UCLA clinical departments, to FACULTY CONSULTATION SERVICE create a multidisciplinary team custom- ized for each patient’s unique medical Patient visits 149,771 153,771 needs. ff Aesthetic Center ff Center for Community Outreach and Policy INPATIENT CONSULTATION SERVICE ƒƒ UCLA Center for Eye Patient evaluations 985 781 Epidemiology ƒƒ UCLA Mobile Eye Clinic ff Center to Prevent Childhood Blindness CLINICAL LABORATORIES ff Center for Regenerative Medicine in Ophthalmology Procedures 83,122 92,235 ff Clinical Research Center ff Contact Lens Center ff Diabetic Eye Disease and Retinal Vascular Center SURGERY SERVICES ff Eye Trauma and Emergency *Number of procedures1 21,970 16,651 Center ff Gerald Oppenheimer Family Intravitreal Injections 12,476 12,748 Foundation Center for the Prevention of Eye Disease ff Glaucoma Center for Excellence in Care and Research MOBILE EYE CLINIC ff Macular Disease Center ff Ocular Inflammatory Disease Number of patients seen 17,646 9,675 Center Ocular abnormalities 31% 33% ff Ophthalmic Oncology Center ff Optic Neuropathy Center Number of trips 789 410 ff Orbital Disease Center ff UCLA Laser Refractive Center ff Vision Genetics Center 1Includes lasers ff Vision Proteomics Center *Revised ff Vision Rehabilitation Center

30 UCLA STEIN EYE INSTITUTE | Eye Health Programs Diagnostic Services Ophthalmology diagnostic services ff Retina Biochemistry and Clinical provide testing that offers precise mea- Disease Modeling Laboratory surements, photographs, and quantita- ff Retinal Biochemistry Laboratory tive studies of the eye and the visual ff Retinal Cell Biology Laboratory system. Diagnostic testing increases ff Retinal Neurophysiology the accuracy of diagnosis and further Laboratory augments the effectiveness of disease ff Vision Molecular Biology management. Our diagnostic services Laboratory are available to eye care physicians in ff Visual Physiology Laboratory the community. ff Anterior Segment Diagnostic Laboratory ff Corneal Diagnostics ff Glaucoma Imaging Laboratory Find out more about our RESEARCH LABORATORIES at: f f Medical Photography/Ultrasound www.uclahealth.org/eye/ ff Ocular Motility Clinical and research-laboratories. Basic Science Laboratory ff Visual Field Laboratory ff Visual Physiology Diagnostic Laboratory

Research Laboratories Laboratory-based research, also called basic vision-science research, forms the foundation for the clinical research, education, and patient care that are the visible hallmarks of the UCLA Stein Eye Institute. The Institute has over 20 specially equipped laboratories to support vision-science investigations. Organized around the interests of the research faculty, these distinct labo- ratories offer unique opportunities for students, physicians, and fellows to become involved in internationally and nationally renowned scientific study. ff Advanced Robotic Eye Surgery ff Biology and Genetics of Retinal Disease ff Cornea Biology Laboratory ff Cornea Genetics ff Developmental Neurobiology Laboratory ff Glaucoma Advanced Imaging Laboratory ff Lens Biophysics Laboratory ff Molecular Biology of Retinal Ganglion Cells Laboratory ff Ocular Motility Laboratory ff Ophthalmic Biophysical Chemistry ff Ophthalmic Pathology Laboratory ff Photoreceptor Biochemistry Laboratory The Stein Eye Institute has substantially increased its laboratory space, opening the door to recruitment of more vision scientists and further development of revolutionary programs to treat ff Photoreceptor/RPE Cell Biology eye disease.

Eye Health Programs | UCLA STEIN EYE INSTITUTE 31 Training Programs

The UCLA Department of Ophthalmol- ogy provides comprehensive training in ophthalmology and vision science to medical students, residents, and clinical and research fellows. Training programs encompass the gamut of ophthalmic and vision-science educa- tion, incorporating a full range of sub- jects in the study of the eye. Serving a large patient population with diverse vision problems offers innumerable training opportunities for both resi- dents and clinical fellows, while the availability of a multitude of research laboratories ensures a wide choice of vision-science projects for all trainees. Predoctoral and postdoctoral research fellows benefit from the wealth of new and unfolding research generated by UCLA Department of Ophthalmology vision scientists.

Medical Students Through the UCLA Medical Student Program, each academic year the UCLA Department of Ophthalmology extends instruction to UCLA medical students in their second, third, and fourth years of instruction. Through lectures, small group discussions, and clinical experience, all students have A continuing theme of residency training is collaboration—creating partnerships in diagnosis, numerous training sessions from which review of challenging patient problems, and learning new techniques. to gain knowledge about eye diseases and develop eye examination skills that should be known by all physicians, regardless of their specialties. Students who are interested in ophthalmology as a career have additional learning opportunities in elective courses.

Medical Student Research Ophthalmology Program The UCLA Medical Student Research Program provides select medical stu- dents with a year-long opportunity to participate in laboratory or clinical research in the field of ophthalmology. The goal of the program is to encour- age medical students to pursue careers in academic ophthalmology.

32 UCLA STEIN EYE INSTITUTE | Eye Health Programs Residents The UCLA Department of Ophthalmol- EyeSTAR: Combining Basic Science ogy Residency Program is ranked one Research with Clinical Practice of the top in the country and covers the For physicians interested in academic full breadth of ophthalmology training careers and professional leadership as from general ophthalmology to oph- clinician-scientists, the Stein Eye Insti- thalmic subspecialties. The accredited tute offers the Ophthalmology Specialty three-year residency program trains Training and Advanced Research Pro- 24 residents with eight new residents gram, referred to as EyeSTAR, which beginning the program each July. offers vision-science training com- Training incorporates the resources bined with an ophthalmology residency. of the UCLA Stein Eye Institute, Har- Appointees complete a residency pro- bor-UCLA Medical Center, Olive View- gram leading to certification in ophthal- UCLA Medical Center, and the Veterans mology, as well as laboratory research Affairs Greater Los Angeles Healthcare experience leading to a doctorate, System at West Los Angeles and Sep- or postdoctoral training in the event ulveda. Through their clinical rotations, that the trainee already has a doctor- every resident has exposure to each ate. EyeSTAR trainees work under the medical center and gains clinical expe- guidance of a faculty advisory panel rience with a broad range of ophthal- representing the clinical and research mic problems and patient populations. interests of each trainee. Certification by the American Board of EyeSTAR is recognized by the Ophthalmology is a natural objective of National Eye Institute and the Associ- the program. ation of University Professors of Oph- thalmology as a model training program EyeMBA: Innovation in for clinician-scientists in ophthalmology. Medical Education Recognizing that future leaders in ophthalmology will need the finan- cial, management, and measurement skills that are at the core of an MBA curriculum, the Stein Eye Institute cre- ated a national first for medical edu- cation with EyeMBA—a master’s of business administration degree that is earned in tandem with an ophthalmol- ogy residency. The only joint program of its kind, the Stein Eye Institute developed EyeMBA with the David Geffen School of Medi- cine at UCLA and the UCLA Anderson School of Management. Residents in the EyeMBA program gain skills that are broadly applicable to ophthalmologic leadership in academia, translational research, health system management, health care delivery, and the biomed- ical industry.

The UCLA Department of Ophthalmology is recognized the world over for its commitment to excellence in patient care, research, and education both locally and globally.

Eye Health Programs | UCLA STEIN EYE INSTITUTE 33 Fellows The UCLA Department of Ophthalmol- Clinical Fellowship Training International Fellowship Training ogy offers particularly well-qualified Following successful completion of the To promote and encourage research persons the opportunity to receive residency program, clinical fellowship and education interaction with oph- fellowship training in vision-science training combines outpatient, inpatient, thalmology institutions throughout the research or specific areas of clinical and surgical experience in an ophthal- world, the Stein Eye Institute offers an ophthalmology. mic subspecialty. The fellow assumes International Ophthalmology Fellow- increasing responsibility for patient ship and Exchange Program consisting Vision Science Fellowship Training care under the supervision of faculty of one-year to two-year fellowships Vision­ science fellowship training is members responsible for the program. under the supervision of specific Insti- laboratory based and offers both pre- In addition to receiving training from tute faculty. Candidates for these fel- doctoral and postdoctoral opportu- faculty, the fellow instructs medical lowships are nominated by prestigious nities to trainees in specific areas of students and residents. Research is institutions outside the United States vision science that encompass a wide considered an important aspect of spe- and often hold academic positions range of topics. Trainees work under cialty training and a major prerequisite within their own countries. Fellows the supervision of UCLA Department of for assimilating future developments in participate in the clinical and research Ophthalmology faculty members who ophthalmology. Fellows are expected activities of ophthalmic subspecialties are engaged in basic-science research to undertake independent investigation according to their training needs. and have active laboratories. The pre- or to participate in one of the ongoing doctoral or postdoctoral trainee and research projects in a field related to his/her faculty mentor develop the their specialty. Find detailed information about scope and nature of the training The Department of Ophthalmology our TRAINING PROGRAMS at: program. offers clinical fellowships at the Stein https://www.uclahealth.org/ An integrated program is also offered Eye Institute and/or the Doheny Eye eye/training-programs. under the auspices of a National Eye Center UCLA in the following subspe- Institute Vision Science Training Grant cialty areas: for predoctoral and postdoctoral fel- ff Cornea and External Ocular lows. The grant provides trainees with Diseases and Refractive Surgery coordinated and organized exposure ff Glaucoma to a wide range of techniques, giv- ing each fellow the broadest possible ff Medical Retina background in ophthalmology and the ff Neuro-Ophthalmology basic sciences. ff Ophthalmic Pathology ff Orbital and Ophthalmic Plastic Surgery ff Pediatric Ophthalmology and Strabismus ff Uveitis and Inflammatory Eye Disease ff Vitreoretinal Diseases and Surgery

34 UCLA STEIN EYE INSTITUTE | Eye Health Programs Faculty and Colleagues UCLA Department of Ophthalmology Academic Divisions at Stein Eye Institute (SEI) and Doheny Eye Centers UCLA (DEC)

CATARACT AND NEURO-OPHTHALMOLOGY RETINAL DISEASES AND REFRACTIVE SURGERY Anthony Arnold, MD, Chief SEI OPHTHALMIC GENETICS John Bartlett, MD Laura Bonelli, MD Michael Gorin, MD, PhD, Chief SEI Shawn Lin, MD Lynn Gordon, MD, PhD Phillip Le, MD, PhD Kenneth Lu, MD Stacy Pineles, MD Colin McCannel, MD Kevin Miller, MD, Chief SEI Peter Quiros, MD Steven Nusinowitz, PhD Mitra Nejad, MD Alfredo Sadun, MD, PhD, Chief DEC SriniVas Sadda, MD Optometrists David Sarraf, MD Tony Chan, OD OPHTHALMIC PATHOLOGY VISION SCIENCE Carolyn Duong, OD Ben Glasgow, MD Linda Hwang, OD Steven Barnes, PhD Mark Landig, OD ORBITAL AND OPHTHALMIC Suraj Bhat, PhD PLASTIC SURGERY Amanda Powers, OD Dean Bok, PhD Robert Goldberg, MD, Chief SEI Nicholas Brecha, PhD COMPREHENSIVE OPHTHALMOLOGY Daniel Rootman, MD Gordon Fain, PhD Gavin Bahadur, MD Debora Farber, PhD, DPhhc PEDIATRIC OPHTHALMOLOGY Rachel Feit-Leichman, MD Ben Glasgow, MD AND STRABISMUS Tania Onclinx, MD Joseph Horwitz, PhD Joseph Demer, MD, PhD, Chief SEI Susan Ransome, MD Wayne Hubbell, PhD Simon Fung, MD Meryl Shapiro-Tuchin, MD Steven Nusinowitz, PhD Monica Khitri, MD Ronald Smith, MD Natik Piri, PhD Stacy Pineles, MD Roxana Radu, MD Optometrists Federico Velez, MD Alapakkam Sampath, PhD, Chief SEI Michael Baker, OD Optometrist Deming Sun, MD Vivian Shibayama, OD Laura Robbins, OD Hui Sun, PhD Gabriel Travis, MD CORNEA AND UVEITIS RETINA David Williams, PhD Anthony Aldave, MD, Chief SEI Gad Heilweil, MD Xian-Jie Yang, PhD Saba Al-Hashimi, MD Hamid Hosseini, MD Yuhua Zhang, PhD Benjamin Bert, MD Jean-Pierre Hubschman, MD Jie Zheng, PhD Sophie Deng, MD, PhD Michael Ip, MD, Chief DEC Gary Holland, MD M. Ali Khan, MD Hugo Hsu, MD, Chief DEC Allan Kreiger, MD John Irvine, MD Colin McCannel, MD Batool Jafri, MD Tara McCannel, MD, PhD Olivia Lee, MD Pradeep Prasad, MD Find out more about our Bartly Mondino, MD, Chairman Steven Schwartz, MD, Chief SEI ACADEMIC DIVISIONS and FACULTY at: GLAUCOMA Irena Tsui, MD Joseph Caprioli, MD, Chief SEI Optometrists www.uclahealth.org/eye/ academic-divisions. Vikas Chopra, MD Melissa Chun, OD Anne Coleman, MD, PhD Jennie Kageyama, OD Brian Francis, MD, Chief DEC JoAnn Giaconi, MD Alex Huang, MD, PhD Simon Law, MD, PharmD Kouros Nouri-Mahdavi, MD Natik Piri, PhD James Tan, MD, PhD

36 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Bartly J. Mondino, MD

Bradley R. Straatsma, MD, Endowed Chair in Ophthalmology Distinguished Professor of Ophthalmology Chairman, UCLA Department of Ophthalmology Director, Stein Eye Institute Affiliation Chairman, Doheny Eye Institute Board of Directors, Stein Eye Institute Board of Directors (Observer), Doheny Eye Institute Board of Directors, National Alliance for Eye and Vision Research/ Alliance for Eye and Vision Research Member, UCLA Brain Research Institute Member, Medical Advisory Board, Braille Institute

Dr. Mondino was named director of the Stein Eye Institute and chairman of the UCLA Department of Ophthalmology in 1994, the culmination of a career in research and clinical care in cornea and infectious eye diseases. As director and chairman, Dr. Mondino has expanded the Stein Eye Institute’s pillar programs; increased faculty support through the ­creation of endowed chairs; forged a historic affiliation with the Doheny Eye ­Institute; and broadened access to eye care with the opening of Stein and Doheny Eye Center UCLA locations across the Southland. Through development and completion of the Edie & Lew Wasser- man Building in 2014, redesign of Stein Plaza in 2015, and renovation of the Jules Stein Building in 2017, Dr. Mondino transformed the Stein Eye Institute into a vision-science campus at UCLA, creating a focal point for patient care, vision research, education, and community outreach at home and abroad.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 37 FACULTY, UCLA STEIN EYE INSTITUTE

Anthony J. Aldave, MD Saba Al-Hashimi, MD Anthony C. Arnold, MD

Walton Li Chair in Cornea and Uveitis Health Sciences Assistant Clinical Mary Oakley Foundation Chair in Professor of Ophthalmology Neurodegenerative Diseases Professor of Ophthalmology Professor of Clinical Ophthalmology Chief of the Cornea and Uveitis Division Cornea, External Disease, and Chief of the Neuro-Ophthalmology Refractive Surgery Specialist Division Discovering the Genetic Basis Dr. Al-Hashimi is a clinician with a Director of the UCLA Optic Neuropathy of the Corneal Dystrophies Center research interest in keratoconus and Dr. Aldave’s clinical specialties are cor- corneal crosslinking. His research focus Vice Chair, Education nea and external disease. His labora- involves halting the progression of cor- tory research focuses on the molecular neal disease by using light and chemi- Ischemic and Inflammatory Diseases genetics of the corneal dystrophies, cals to strengthen the cornea. of the Optic Nerve a group of inherited disorders that Specializing in infections of the cor- Dr. Arnold’s clinical expertise is in affect corneal clarity and constitute one nea, Dr. Al-Hashimi performs surgi- neuro-ophthalmology, with a special of the primary indications for corneal cal procedures that include corneal emphasis on ischemic and inflamma- transplantation. transplantation, Descemet membrane tory optic neuropathies and manifes- Dr. Aldave provides clinical care at stripping endothelial keratoplasty, tations of tumors, stroke, and inflam- the Stein Eye Institute in Westwood. Descemet membrane endothelial kera- mation of the central nervous system. toplasty, deep anterior lamellar kerato- His research has focused on advanced plasty, corneal patch grafts, ­pterygium imaging techniques to identify optic surgery, corneal repair, cataract sur- nerve circulatory diseases and to inves- gery, and premium cataract surgery tigate their causes. with femtosecond laser. Dr. Arnold provides clinical care at Patients can see “Dr. Saba” at the the Stein Eye Institute in Westwood. UCLA Stein Eye Institute.

38 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Gavin G. Bahadur, MD John D. Bartlett, MD Suraj P. Bhat, PhD

Health Sciences Assistant Clinical Health Sciences Assistant Clinical Oppenheimer Brothers Chair* Professor of Ophthalmology Professor of Ophthalmology Professor of Ophthalmology Member of the Molecular Biology Institute Cataract Surgery Outcomes and Cataract and Refractive Surgery, Glaucoma Detection Clinical Informatics Molecular Biology of Vision Dr. Bahadur’s clinical specialties are Dr. Bartlett’s clinical interest is cataract comprehensive ophthalmology includ- and refractive cataract surgery, with the Dr. Suraj Bhat’s research impacts two ing cataract, pterygium, and glaucoma. goal to improve the focus of the eyes, important areas of vision: the ocular His research activities include machine- reduce dependence on glasses, and lens in the anterior eye and the retinal learning algorithms for cataract surgery restore vision potential. He teaches pigment epithelium (RPE) in the pos- outcomes and glaucoma detection. Stein Eye residents, training the next terior eye. His laboratory, the Vision Dr. Bahadur provides clinical care generation of eye surgeons to deal Molecular Biology Laboratory (VMBL) at the Stein Eye Center–Santa Monica. with challenging cases. investigates gene activity that sustains Dr. Bartlett is a UCLA physician infor- transparency within the ocular lens and maticist and is involved in the imple- gene activity that sustains the physio- mentation and optimization of elec- logical health of the RPE, which in turn tronic health records (EHRs) to promote sustains the neural activity in the ret- effective organization, analysis, man- ina that makes vision possible. VMBL agement, and use of clinical informa- is involved in delineating very early tion. He is interested in using EHRs to events (at the genomic and molecular enhance patient care, improve pop- level) that culminate in cataractogene- ulation health, and decrease health sis in the ocular lens and age-related care costs. macular degeneration in the RPE. Dr. Bartlett provides clinical care at the Stein Eye Institute in Westwood.

*pending

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 39 Ava K. Bittner, OD, PhD Nicholas C. Brecha, PhD Joseph Caprioli, MD

Smotrich Family Optometric Distinguished Professor of Neurobiology, David May II Chair in Ophthalmology Clinician-Scientist Chair Ophthalmology, and Medicine Distinguished Professor Chief of Optometric Services Member of the Brain Research Institute of Ophthalmology Associate Professor of Ophthalmology Member of CURE: Center for Chief of the Glaucoma Division Digestive Diseases Low Vision Rehabilitation Member of the California NanoSystems Causes and New Treatments Institute for Glaucoma Dr. Bittner’s specialty is low vision rehabilitation. Her research activities Functional and Structural Dr. Caprioli’s clinical specialties are include clinical trials to assess the use Organization of the glaucoma, cataract, and anterior seg- of novel approaches and technolo- Mammalian Retina ment surgery. His long-term objectives gies to improve access to low vision in clinical and basic research are to rehabilitation care and reading ability Dr. Brecha is a visual system neurosci- identify those individuals at greatest with visual assistive aids. Specifically, entist whose expertise includes retinal risk for visual loss and to implement she is evaluating tele-rehabilitation, neurochemistry, transmitters, synaptic new treatment through effective neuro­ Bluetooth low energy beacon sensors, and cellular structure, and neuronal cir- protective strategies. Laboratory work socially assistive robots, and wearable cuitry regulating visual function. focuses on mechanisms of retinal gan- electronic visual enhancement devices His current research studies are fur­ glion cell damage in glaucoma. He for low vision. thering the understanding of 1) funda- focuses on early detection through Dr. Bittner provides clinical care at mental synaptic inhibitory processes accurate assessment of the optic nerve the Stein Eye Institute’s Vision Reha- mediating early vision in the outer ret- and nerve fiber layer to measure the bilitation Center located in the Doris ina and 2) neuronal cell structure and rate of progressive damage. Stein Building. function mediating visual processing Dr. Caprioli provides clinical care at in the inner retina. the Stein Eye Institute in Westwood. His studies are a prerequisite for understanding normal retinal function, and the impact on the development of therapeutic approaches and diagnostic tools essential for the treatment, pre- vention, and restoration of vision loss due to retinal injury and disease.

40 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Anne L. Coleman, MD, PhD Joseph L. Demer, MD, PhD Sophie X. Deng, MD, PhD

The Fran and Ray Stark Foundation Arthur L. Rosenbaum, MD, Chair in Joan and Jerome Snyder Chair in Chair in Ophthalmology Pediatric Ophthalmology Cornea Diseases* Professor of Ophthalmology Professor of Ophthalmology Professor of Ophthalmology Professor of Epidemiology, Jonathan and Professor of Neurology Member of the UCLA Jonsson Karin Fielding School of Public Health Comprehensive Cancer Center Chief, Pediatric Ophthalmology and Director of the Stein Eye Institute Strabismus Division Member of the UCLA Broad Stem Cell Centers for Community Outreach and Research Center Director, Fellowship in Pediatric Policy, Eye Epidemiology, and the Ophthalmology and Strabismus UCLA Mobile Eye Clinic Director, Ocular Motility Laboratories Limbal Stem Cell Deficiency Vice Chair of Academic Affairs, UCLA Department of Ophthalmology Chair, EyeSTAR Residency-PhD/PostDoc Dr. Deng specializes in corneal and Program in Ophthalmology and external ocular diseases, and cataracts. Visual Science Glaucoma, Cataract, and Her surgical areas include endothelial Public Health keratoplasty (DSEK and DMEK), deep Motility and Vision anterior lamellar keratoplasty (DALK), Dr. Coleman’s clinical specialties are penetrating keratoplasty, limbal stem glaucoma and cataract. Her research Dr. Demer’s clinical specialties include cell transplantation, artificial cornea, activities include the etiology, diagnosis, pediatric ophthalmology, adult stra- and cataract. treatment, and societal impact of glau- bismus, and other disorders of ocular Dr. Deng is the director of the Cor- coma, cataracts, and pediatric eye dis- motility such as nystagmus. He is a nea Biology Laboratory at Stein Eye. eases including quality-of-life research biomedical engineer whose federally Her research focuses on corneal epi- for patients impacted by these eye dis- funded research includes anatomy and thelial stem cell regulation, deficiency, eases. Her research encompasses the imaging of the eye muscles, and the and regeneration. She aims to improve interface of eye care and public health biomechanics of eye movements and the current treatment for patients with focusing on underserved areas. optic nerve disorders. limbal stem cell deficiency by using Dr. Coleman provides clinical care Dr. Demer provides clinical care and stem cell therapy to restore vision. at the Stein Eye Institute in Westwood. ophthalmic surgery at the Stein Eye Institute in Westwood. Dr. Deng also conducts clinical studies to develop new imaging and molecular tests to accurately diagnose and stage limbal stem cell deficiency.

*pending

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 41 Debora B. Farber, PhD, Simon Fung, MD JoAnn A. Giaconi, MD DPhhc Assistant Professor of Ophthalmology Health Sciences Associate Clinical Professor of Ophthalmology Distinguished Professor of Ophthalmology Pediatric Ophthalmology and Chief of the Ophthalmology Section at the Greater Los Angeles Doctor honoris causa Cornea Specialist VA Healthcare System Member of the Brain Research Institute Dr. Fung’s clinical interests are child- Co-Director of Medical Student Member of the Molecular Biology hood cornea and anterior segment dis- Education at the David Geffen Institute eases. His research focuses on eval- School of Medicine, UCLA uation of pediatric cornea conditions Retinal Biochemistry, Molecular using novel imaging technologies. Adult and Pediatric Glaucoma Biology, Genetics of Retinal After finishing his residency in 2015, Dr. Giaconi’s areas of clinical specialty Degenerations, and Studies on Dr Fung undertook a fellowship in adult are adult and pediatric glaucoma and Embryonic Stem Cell-Derived cornea and external disease at Moor- cataract surgery. Her research inter- Extracellular Vesicles fields Eye Hospital in London, England, ests are in the outcomes of glaucoma followed by a second fellowship in Dr. Farber’s research focuses on the surgery. She also has a strong interest pediatric cornea and anterior segment characterization of genes encoding key in medical education. at The Hospital for Sick Children in proteins in vision that when mutated Dr. Giaconi provides clinical care Toronto, Canada. Dr. Fung became a cause blinding diseases. Examples: at the Stein Eye Institute in Westwood UCLA Department of Ophthalmology b-PDE gene (diseases in mice, dogs, and at the Veterans Administration Eye faculty member in 2018. and human RP), RP1 gene (dominant Clinic West Los Angeles campus. RP), rd7 gene (Enhanced S-Cone syn- Dr. Fung provides clinical care at the drome), and ZBED4 and RHBDD2 UCLA Stein Eye Institute in Westwood. genes (arCRD and arRP, respectively). In addition, Dr. Farber studies ocular albinism resulting from lack of the OA1 gene, and the components of the OA1 cascade controlling RPE melanosomes’ biogenesis and guidance of ganglion cell axons through the brain’s optic chiasm. Lastly, Dr. Farber investigates the use of microvesicles released from embryonic stem cells for the rescue of damaged retinas.

42 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Ben J. Glasgow, MD Robert Alan Goldberg, MD Lynn K. Gordon, MD, PhD

The Wasserman Professor Bert O. Levy Endowed Chair in Vernon O. Underwood Family Chair of Ophthalmology Orbital and Ophthalmic Plastic Surgery in Ophthalmology Professor of Pathology and Professor of Ophthalmology Professor of Ophthalmology Laboratory Medicine Chief of the Orbital and Ophthalmic Senior Associate Dean for Chief of the Ophthalmic Pathology Plastic Surgery Division Academic Diversity, David Geffen Division School of Medicine at UCLA Director of the UCLA Orbital Disease Center Chair of the College of Applied Anatomy, David Geffen School of Medicine Ophthalmic Pathology Co-Director of the UCLA Aesthetic Center at UCLA Dr. Glasgow specializes in ophthalmic pathology, and his research focus is Diseases and Therapy of the Neuro-Ophthalmology and the role of human lacrimal gland pro- Eyelid and Orbit Inflammatory Disease teins in the protection and maintenance Dr. Goldberg is an internationally recog- Dr. Gordon’s clinical specialty is neuro- of the eye. His laboratory is investi- nized surgeon, researcher, and teacher. gating the structure-function relation- ophthalmology. Her research centers He has developed surgical procedures on inflammatory diseases of the eye ship of tear lipocalin. By studying the that are now globally taught and prac- molecular mechanisms of tear proteins, and adnexa and the role of the four ticed, including less invasive treatments transmembrane protein epithelial mem- Dr. Glasgow is seeking to learn the for eye and orbit cancers, new surger- normal functions of tear lipocalin and brane protein 2 in ocular and cancer ies for thyroid eye disease, and inno- angiogenesis. Dr. Gordon is also the its role in maintaining the health of the vative surgical techniques for tearing ocular surface and in the prevention of Senior Associate Dean for Equity and problems. His research into orbital and Diversity Inclusion at the David Geffen dry eye diseases. Ideally this research eyelid anatomy is resulting in improved will lead to new treatments for dry eye School of Medicine at UCLA. techniques and approaches to deep Dr. Gordon provides clinical care in and have broad application to numer- orbital disease. He has had leader- ous other members of this protein fam- neuro-ophthalmology at the Stein Eye ship and executive positions in the Institute in Westwood. ily that transport small, insoluble mole- American Society Ophthalmic Plas- cules through the body. tic Reconstructive Surgery, California Academy of Eye Physicians and Sur- geons, and the American Academy of Cosmetic Surgery.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 43 Michael B. Gorin, MD, PhD Gary N. Holland, MD Hamid Hosseini, MD

Harold and Pauline Price Chair Jack H. Skirball Chair in Assistant Professor of Ophthalmology in Ophthalmology Ocular Inflammatory Diseases Professor of Ophthalmology Professor of Ophthalmology Retinal and Macular Conditions Professor of Human Genetics Director of the Ocular Inflammatory Disease Center Dr. Hosseini specializes in retinal and Chief of the Division of Retinal Disorders macular conditions, such as macular and Ophthalmic Genetics Director of the UCLA Department of Ophthalmology Clinical Research Center degeneration, diabetic retinopathy, and retinal detachment. Co-Director of Medical Student Education Hereditable Eye Disorders and Dr. Hosseini completed two fellow- Molecular Genetics of ships at the UCLA Stein Eye Institute, Age-Related Maculopathy Uveitis and Cornea-External the first in glaucoma and the second in Ocular Diseases Dr. Gorin’s clinical expertise is in med- retina. He participates in all activities of ical retina and ophthalmic genetic dis- Dr. Holland specializes in uveitis and the Retina Division, including research, orders. He has both a basic and trans- other inflammatory diseases of the eye. education, and clinical care. lation research program that address His research activities focus on risk He sees patients at the Stein Eye the genetics of inherited retinal dystro- factors for, and clinical characteristics Institute in Westwood and Harbor- phies and age-related macular degen- of, various infectious and inflammatory UCLA Medical Center. eration, the biological basis of pain diseases, including ocular toxoplas- caused by light exposure, the study of mosis, cytomegalovirus retinitis, and von Hippel Lindau disease, etiology of chronic anterior uveitis in children. central serous chorioretinopathy, drug Dr. Holland provides clinical care at and autoimmune-related retinopathies, the Stein Eye Institute in Westwood. genetics-based therapies for disease, and late-life morbidities associated with retinopathy of prematurity. Dr. Gorin was among the first UCLA physicians to be boarded in Clinical Informatics, and he is exploring the use and analysis of clinical datasets to better understand disease and clini- cal outcomes.

44 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Wayne L. Hubbell, PhD Jean-Pierre Hubschman, MD Sherwin J. Isenberg, MD

Jules Stein Chair in Ophthalmology Associate Professor of Ophthalmology Laraine and David Gerber Chair in Ophthalmology Distinguished Professor of Ophthalmology Advanced Vitreoretinal Distinguished Professor of Ophthalmology Distinguished Professor of Surgical Interventions and Robotics Chemistry and Biochemistry Professor of Pediatrics Dr. Hubschman’s clinical research focuses on the development and eval- Molecular Basis of Phototransduction Pediatric Ophthalmology, uation of new vitreoretinal surgical in the Vertebrate Retina Amblyopia, and techniques and robotics for ophthalmic Ophthalmic Pharmacology Dr. Hubbell’s research is focused on surgery. Automated surgery utilizing understanding the relationship between robotics promises to increase surgi- Dr. Isenberg is a pediatric surgical and molecular structure, plasticity, and con- cal precision and accuracy, as well medical disease specialist. His research formational changes that control protein as improve access to medical care. has concentrated on decreasing the fre- function in the visual system. Of partic- Dr. Hubschman’s publications include quency of blindness in children world- ular interest are proteins that behave as research papers on the development wide and preventing pediatric vision “molecular switches.” The overall goal of a new retinal patch for the treatment loss from debilitating eye infections is to determine the structure of these of retinal detachment, on the feasibility that impact more than 10,000 children proteins in their native environment, of robotic surgery in ophthalmology, a year in low-resource countries. monitor the changes in structure that and results of various clinical trials. Cur- Dr. Isenberg has authored nearly accompany the transition to an active rently, he is also investigating the use 200 research papers, book chapters, state, and to understand the role of of the terahertz laser for the evaluation and two editions of “The Eye in Infancy.” protein flexibility in function. of ocular tissue hydration. Among his leadership positions, Dr. To investigate these and other pro­ Dr. Hubschman provides clinical care Isenberg has served as vice chair of the teins, Dr. Hubbell’s laboratory has devel- at the Stein Eye Institute in Westwood. UCLA Department of Ophthalmology, oped the technique of site-directed chief of the Division of Ophthalmology spin labeling, a novel and powerful at Harbor-UCLA Medical Center, and approach to the exploration of protein president of the American Associa- structure and dynamics. tion for Pediatric Ophthalmology and Strabismus.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 45 Simon K. Law, MD, PharmD Ralph D. Levinson, MD Colin A. McCannel, MD

Health Sciences Clinical Professor Health Sciences Clinical Professor Professor of Clinical Ophthalmology of Ophthalmology of Ophthalmology Vitreoretinal Surgery Optic Disc Evaluation Ocular Inflammatory Diseases Dr. McCannel has a longstanding inter- Dr. Law’s clinical specialties are glau- Dr. Levinson’s research interest is in est in the management of vitreoreti- coma and cataract. His research activ- both the clinical aspects of uveitis and nal conditions, particularly complex ities include evaluation of the optic the basic mechanisms and immunoge- retinal detachments, complications nerve in different racial groups and netics of ocular inflammation. Current of diabetic retinopathy, macular holes ocular pathologies, different patterns of projects include a collaborative longi- and epimacular membranes, and age-­ glaucomatous visual function decline, tudinal study of a chronic inflammatory related macular degeneration. His clin- outcomes of different glaucoma sur- disease, birdshot chorioretinopathy, ical research efforts are directed at the gical procedures and medications in with investigators in France. The study improvement of vitreoretinal surgical eye pressure control and vision resto- focuses on the interrelationship of dis- techniques and outcomes, including ration, and alternative therapy in glau- ease factors, as well as the course of the prevention of endophthalmitis fol- coma care. disease and response to treatment. lowing intra­vitreal injections. Dr. Law provides clinical care at the Dr. Levinson is also conducting labora- Dr. McCannel devotes time to edu- Stein Eye Institute in Westwood. tory research on cell-based therapies cational research as well. Currently, he for uveitis and is a co-investigator for is investigating the utility of virtual real- National Eye Institute-funded labora- ity surgery simulation in teaching oph- tory research on the effects of cancer thalmic surgery. He has several ongo- immunotherapy on uveitis. ing protocols that assess ophthalmic surgical simulation in surgical teaching. Dr. McCannel provides clinical care at the Stein Eye Institute in Westwood.

46 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Tara A. McCannel, MD, PhD Kevin M. Miller, MD Kouros Nouri-Mahdavi, MD, MSc Health Sciences Associate Clinical Kolokotrones Chair in Ophthalmology Professor of Ophthalmology Professor of Clinical Ophthalmology Associate Professor of Ophthalmology Director of the Ophthalmic Oncology Chief of the Cataract and Refractive Director of the Glaucoma Advanced Center Surgery Division Imaging Laboratory Director of the Anterior Segment Metastatic Ocular Melanoma and Diagnostic Laboratory Role of Structural and Functional Diseases of the Retina and Vitreous Measurements for Detection of Dr. McCannel is an ophthalmic oncolo- Cataract and Refractive Surgery Glaucoma and Its Progression gist, as well as a vitreoretinal surgeon. Dr. Miller is chief of the Cataract and Dr. Nouri-Mahdavi’s areas of clinical Dr. McCannel’s Ophthalmic Onc­ ology Refractive Surgery Division and direc- interest are glaucoma and complex Laboratory is studying molecular mark- tor of the Anterior Segment Diagnos- cataract surgery. His research activities ers in ocular melanoma to provide tic Laboratory. His research interests include optimizing the role of struc- prognostic information to patients and include devices and implants used in tural and functional measurements for advance understanding of metastatic cataract and refractive surgery, out- detection of glaucoma and its progres- disease. Discovery of candidate genes comes of surgical procedures, astig- sion with an emphasis on advanced from tissue of patients undergoing sur- matism management, and artificial iris disease and macular optical coherence gical treatment for ocular melanoma is implantation. tomography imaging. He is also inter- being explored. This information will be Dr. Miller provides patient care in ested in the study of glaucoma treat- important to establish a better under- the Cataract and Refractive Surgery ment outcomes and their predictors, standing of the biology of metastatic Suite on the second floor of the Edie such as ethnicity. A recent publication ocular melanoma and help develop and Lew Wasserman Building at the compared long-term outcomes of tra- better treatments for this cancer. New Stein Eye Institute. beculectomy with adjunctive mitomy- modalities are being investigated to cin C in patients of African descent to predict, detect, and ultimately treat those of European descent. choroidal melanoma metastasis. Dr. Nouri-Mahdavi provides clini- Dr. McCannel provides clinical care cal care at the Stein Eye Institute in at the Stein Eye Institute in Westwood. Westwood and the Stein Eye Center– Santa Monica.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 47 Steven Nusinowitz, PhD Stacy L. Pineles, MD Natik Piri, PhD

Professor of Ophthalmology Jerome and Joan Snyder Chair Professor of Ophthalmology in Ophthalmology Co-Director of the Visual Physiology Laboratory Associate Professor of Ophthalmology Retinal Ganglion Cell Biology, Director of the Live Imaging and Residency Director, Department Glaucomatous Neurodegeneration, Functional Evaluation (LIFE) Core of Ophthalmology and Neuroprotection Dr. Piri’s primary research is defining the Mechanisms of Retinal Pediatric Neuro-Ophthalmology, mechanisms leading to retinal ganglion Degeneration Amblyopia, and Neurologic Causes cell (RGC) degeneration in glaucoma- of Strabismus Dr. Nusinowitz is a visual physiologist tous neuropathy; developing strategies whose primary research interest is the Dr. Pineles’ research interests include for preserving RGCs against neurode- study of the sites and mechanisms of evaluating the surgical outcomes of generation; and identifying and char- disease action in inherited eye dis- strabismus surgery and studying pedi- acterizing the genes critical for RGC eases. He is focused on understanding atric optic nerve diseases. With her dual function and integrity. Characterization the cellular contributions to noninva- training in pediatric ophthalmology and of RGC-expressed genes is fundamen- sive measures of visual function and neuro-ophthalmology, she has a special tal to a better understanding of normal defining the sites and mechanisms interest in pediatric neuro-ophthalmic RGC physiology and pathophysiology. of disease action in inherited retinal diseases, as well as adult patients with Dr. Piri also focuses on understand- and visual pathway disorders. By test- amblyopia and neurologic causes of ing the degeneration of RGCs and their ing hypotheses about the ­underlying strabismus. axons, which is a hallmark of glaucoma. pathophysiology in human disease, Dr. Pineles provides clinical care at He is also studying the involvement Dr. Nusinowitz hopes to provide a the Stein Eye Institute in Westwood. of oxidative stress and proteins of the mechanism for the development of thioredoxin system, particularly in RGC specific diagnostic tools that are suf- degeneration in the glaucoma model, ficiently sensitive for early detection and the neuroprotective effects of and better diagnosis of clinical disease. these proteins against glaucomatous RGC death.

48 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Pradeep S. Prasad, MD, Roxana A. Radu, MD Alapakkam P. Sampath, PhD MBA Assistant Professor of Ophthalmology Professor of Ophthalmology and Neurobiology Health Sciences Assistant Clinical Professor Retina Biochemistry and Clinical Associate Director of the Stein Eye Institute Chief, Division of Ophthalmology, Disease Modeling Laboratory Harbor-UCLA Medical Center Chief, Vision Science Division Dr. Radu’s scientific interest is to understand the mechanism of pho- Vitreoretinal Surgery and Molecular Mechanisms Underlying toreceptor cell degeneration by inte- Disease Management Early Visual Processing grating genetic, biochemical, cellular, Dr. Prasad specializes in the medical and molecular approaches. Dr. Radu’s The Sampath laboratory is interested and surgical management of diseases research focuses on the formation and in understanding the molecular mech- of the retina and vitreous. His research pathogenic role of bisretinoids in reti- anisms underlying early visual process- is focused on teleretinal screening for nopathies such as recessive Stargardt ing. In particular, the focus of laboratory diabetic retinopathy, applications of disease and age-dependent macu- researchers has been on ­elucidating wide-field fundus photography for ret- lar degeneration. Her group aims to mechanisms that set the sensitivity of inal vascular disease, and health care develop disease experimental models night vision. Night blindness, or nycta- delivery for low-income populations. to investigate the bisretinoid-mediated lopia, is a condition that results from Dr. Prasad serves as the chief of the complement dysregulation in the retinal abnormal signaling by the rod photo- Division of Ophthalmology at Harbor- pigment epithelium as a key player in receptors, or the retinal circuits that UCLA Medical Center where he pro- visual loss. Her studies are supported process rod-driven signals. Using phys- vides clinical supervision and instruc- by the NIH, private foundations, and iological and genetic methods, the lab- tion to UCLA medical students as well philanthropic funds. Dr. Radu is also oratory studies signal transmission in as to Stein Eye residents and vitreo- actively involved in training and teach- these retinal rod pathways to identify retinal fellows. ing undergraduates, postgraduate fel- how these processes are optimized to lows, and medical students. allow our exquisite visual sensitivity.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 49 David Sarraf, MD Steven D. Schwartz, MD Soh Youn Suh, MD

Health Sciences Clinical Professor The Ahmanson Chair in Ophthalmology Health Sciences Clinical Instructor of Ophthalmology Professor of Ophthalmology Chief of the Retina Division Pediatric Ophthalmology and Age-Related Macular Degeneration Director of the UCLA Diabetic Adult Strabismus and Retinal Imaging Eye Disease and Retinal Vascular Center Dr. Suh’s clinical specialties are pediat- Dr. David Sarraf is clinical professor of Director of the Macula Center ric ophthalmology and adult strabismus. ophthalmology at the Stein Eye Institute Her research interests include evalu- at UCLA and member of the Retinal Retinal Diseases and ating strain on the optic nerve head and Disorders and Ophthalmic Genetics Stem Cell Research globe displacement during horizontal Division. He has published over 200 ductions in patients and normal controls research papers, reviews, and chap- Dr. Schwartz’s primary areas of research using magnetic resonance imaging and ters and has delivered over 200 invited include early diagnosis and treatment optical coherence tomography. lectures at various meetings worldwide of diseases such as retinopathy of pre- Dr. Suh provides clinical care at the including several endowed and key- maturity, diabetic eye disease, and Stein Eye Institute in Westwood and note lectures. macular degeneration. Dr. Schwartz’s Olive View-UCLA Medical Center. Dr. Sarraf’s research interest cen- research includes evaluation of meth- ters on retinal disease, especially age-­ ods to measure optic nerve damage, related macular degeneration. He is a and the role of structural and functional world leader and pioneer in the field measurements for detection of glau- of advanced retinal imaging systems coma and its progression. Dr. Schwartz such as optical coherence tomogra- also leads clinical trials testing the use phy (OCT) imaging of the macula and of stem cells to address vision loss OCT angiography for the evaluation from Stargardt macular dystrophy and and management of macular disease. dry age-related macular degeneration. Dr. Schwartz provides clinical care at the Stein Eye Institute in Westwood.

50 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Hui Sun, PhD Gabriel H. Travis, MD Irena Tsui, MD

Professor of Physiology and Charles Kenneth Feldman Chair Assistant Professor of Ophthalmology Ophthalmology in Ophthalmology Member of Jonsson Comprehensive Professor of Ophthalmology Clinical Vitreoretinal Research Cancer Center Dr. Tsui’s clinical activities include adult Biochemistry of Vertebrate and pediatric vitreoretinal diseases. Molecular Mechanism of Vitamin A Photoreceptors and Mechanisms of Transport for Vision; Identification Retinal Degeneration Her research interests focus on reti- of New Therapeutic Targets for nopathy of prematurity and Zika virus Blinding Diseases Dr. Travis’ laboratory uses biochemical eye abnormalities. Dr. Tsui teaches and genetic approaches to study the ophthalmology trainees and serves Dr. Sun’s laboratory aims to identify visual cycle and its role in retinal and veterans at the Greater Los Angeles new therapeutic targets to treat still macular degenerations. Vision in ver- VA Healthcare System. incurable human diseases, to study tebrates is mediated by two types of Dr. Tsui provides clinical care at the their molecular mechanisms, and to light-sensitive cells: rods and cones. Stein Eye Institute in Westwood and develop novel therapies based on These cells contain light-detecting mol- the Doheny Eye Center UCLA–Arcadia. the mechanisms. Through many years ecules called opsin pigments. Detec- of research efforts, his laboratory has tion of a single light particle bleaches identified the cell-surface receptors for the opsin pigment. Restoring light sen- the most potent endogenous inhibitor sitivity to a bleached opsin involves an of angiogenesis, developed novel tech- enzymatic pathway called the visual niques to screen for drugs that target cycle. Mutations in the genes for many these receptors, and developed the proteins of the visual cycle cause inher- first small molecule drug candidates ited blinding diseases. that specifically suppress pathogenic angiogenesis in diverse vision diseases and in cancer. These molecules have achieved therapeutic effects that no existing drugs can achieve and are being prepared for clinical trials.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 51 Soheab Ugradar, MD David S. Williams, PhD Xian-Jie Yang, PhD

Health Sciences Clinical Instructor Karl Kirchgessner Foundation Chair in Ernest G. Herman Chair Vision Science* in Ophthalmology Orbital and Ophthalmic Professor of Ophthalmology Professor of Ophthalmology and Neurobiology Plastic Surgery Development and Disease Therapy Dr. Ugradar came to Stein Eye from Cell Biology of the Retina and of the Retina London, England, as an international Inherited Retinal Disease fellow specializing in orbital and oph- Dr. Yang’s research is focused on thalmic plastic surgery. He conducted Dr. Williams’ laboratory focuses on molecular mechanisms of retina de- his ophthalmology residency at Moor- the cell biology of photoreceptor and velopment and repair. Her research fields Eye Hospital, where he is an hon- retinal pigment epithelium cells. His approaches include using genetically orary research fellow. Dr. Ugradar was group is especially interested in pro- engineered retinal degeneration mod- ranked number one in the UK National teins that function in transport and com- els, recombinant virus mediated gene Recruitment for Ophthalmology and is partmentalization within these cells. delivery, and human pluripotent stem the recipient of numerous academic These proteins include those that cell-derived retinal neurons to simulate scholarship awards and honors for underlie Usher syndrome and macu- human diseases. his research, including the Ophthal- lar degeneration. Translational areas Dr. Yang’s research laboratory is mology Research Gold Medal UK, the of his research involve gene therapy located at the Stein Eye Institute in Bernice Brown Fellowship Award, the experiments aimed at preventing the West­wood. Her research activities Young European researcher’s award, blindness that ensues from Usher syn- are support by NIH grants and institu- and the Drapers’ Company Prize for drome type 1B and studies on stem tional support. outstanding achievement at an under- cell-derived RPE cells, which may be graduate level. transplanted into retinas afflicted by Dr. Ugradar sees patients at the macular degeneration. Stein Eye Institute in Westwood.

*pending

52 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Jie J. Zheng, PhD

Professor of Ophthalmology Member of the Molecular Biology Institute Member of the Jonsson Comprehensive Cancer Center

Therapeutic Development in Ophthalmology Dr. Zheng’s research is at the interface of biochemistry, computational biology, systems pharmacology, and drug dis- covery with an emphasis on therapeutic development in ophthalmology. His laboratory is currently develop- ing proteins and small molecules that can modulate signal transduction path- ways, such as Wnt, Hedgehog, BMP, and Hippo pathways, in an effort to better understand the biological func- tions of these signaling pathways and to explore the therapeutic potential of these compounds and proteins. Aiming to establish new translational research within the scientific community at UCLA, Dr. Zheng’s goal is to develop novel therapies for retinal degenerative dis- eases, glaucoma, and corneal disorders.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 53 FACULTY, DOHENY EYE CENTER UCLA

Steven A. Barnes, PhD Benjamin B. Bert, MD Vikas Chopra, MD

Professor of Ophthalmology Health Sciences Assistant Clinical Health Sciences Associate Clinical Professor of Ophthalmology Professor of Ophthalmology Ion Channel Function in Charles Stewart Warren and Retinal Neurons Cornea-External Ocular Disease and Hildegard Warren Endowed Research Chair Dr. Barnes is a neurobiologist inter- Refractive Surgery Medical Director, ested in how the retinal milieu in healthy Dr. Bert provides comprehensive oph- Doheny Eye Center UCLA–Pasadena and stressed states affects ion chan- thalmic care and is a subspecialist in nels that mediate signaling within and cornea/external disease. His areas Glaucoma between retinal neurons. The activity of expertise include: dry eye/blepha- of ion channel proteins in retinal neu- ritis, conjunctivitis, uveitis, acute cor- Specializing in glaucoma, Dr. Chopra’s rons governs how the retinal network neal injury, and genetic corneal disor- research activities include advanced optimizes image processing. Dr. Barnes ders, as well as cataract surgery with optic nerve and retinal nerve fiber layer seeks to define targets that could aid advanced intraocular lenses and refrac- imaging for early glaucoma detection, precision interventions in slowing or tive surgery. as well as development and validation preventing vision loss in diseases such Dr. Bert sees patients at the Doheny of novel parameters for use in anterior as glaucoma and macular degenera- Eye Center UCLA offices in Orange segment optical coherence tomogra- tion. Important questions concern the County and Pasadena. phy devices as principal investigator limits that the bioenergetic environment at the Doheny Image Reading Center. puts on photoreceptor and ganglion Dr. Chopra also evaluates laser and sur- cell sensitivity and signaling capabili- gical techniques for the management ties, as well as how early stages of this of glaucoma. dysfunction are manifested. Dr. Chopra provides patient care at the Doheny Eye Center UCLA locations in Arcadia and Pasadena.

54 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Brian A. Francis, MD, MS Gad Heilweil, MD Hugo Y. Hsu, MD

Health Sciences Clinical Professor Health Sciences Assistant Clinical Health Sciences Clinical Professor of Ophthalmology Professor of Ophthalmology Rupert and Gertrude I. Stieger Vision Research Chair Degenerative Retinal Disease Cornea and External Diseases Director of Glaucoma Services, Doheny Eye Center UCLA Dr. Heilweil’s research activities include Dr. Hsu specializes in corneal infection stem-cell therapy for degenerative and inflammation, corneal transplanta- Medical Director, Doheny Eye Center UCLA–Orange County retinal disease; retinal and uveal drug tion, anterior segment reconstruction, toxicity; and pharmacokinetics of intra- and cataract surgery. His research vitreal drugs. interests include corneal and ocular Glaucoma In addition to providing patient care infections and ophthalmic antibiotics. Dr. Francis’ clinical specialties are at the Stein Eye Institute in Westwood, Dr. Hsu sees patients at the Doheny glaucoma and complex cataract. His Dr. Heilweil also sees patients at the Eye Center UCLA locations in Arcadia, research activities include: innovative Doheny Eye Center UCLA locations in Orange County, and Pasadena. glaucoma surgeries, minimally inva- Arcadia, Orange County, and Pasadena. sive glaucoma surgery, novel visual field techniques, glaucoma diagnos- tic and functional imaging, anterior segment imaging (ultrasound biomi- croscopy and Fourier domain optical coherence tomography), and glaucoma laser surgery. Dr. Francis sees patients at the Doheny Eye Center UCLA locations in Arcadia, Orange County, and Pasadena.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 55 Alex A. Huang, MD, PhD Michael S. Ip, MD John A. Irvine, MD

Assistant Professor of Ophthalmology Gavin S. Herbert Endowed Chair Health Sciences Clinical Professor of Ophthalmology Professor of Ophthalmology Glaucoma A. Ray Irvine, Jr., MD, Chair in Clinical Ophthalmology Vitreoretinal Disease Dr. Huang’s clinical specialties are Medical Director, in complex cataract and glaucoma Dr. Ip is the chief of the Vitreoretinal Sur- Doheny Eye Center UCLA surgery. His research is dedicated to gery Service at the Doheny Eye Center understanding fluid flow in the eye to UCLA. His practice concentrates on Cornea and External Diseases improve and customize glaucoma sur- the surgical management of complex Dr. Irvine’s clinical specialties are cor- gery. He also studies ocular changes retinal detachment, complications of nea and external diseases (eg, tumors, that American astronauts experience diabetic retinopathy, macular holes, infections), anterior segment surgical in Space. epiretinal membranes, and other vit- consultation, and prosthetic replace- Dr. Huang provides clinical care at the reoretinal diseases amenable to surgi- ment of the ocular surface ecosystem Doheny Eye Center UCLA–Pasadena. cal intervention. (PROSE). His research activities focus Dr. Ip’s research focuses on the on ocular infections. design and conduct of clinical trials Dr. Irvine provides patient care at investigating treatments for diabetic ret- the Doheny Eye Center UCLA loca- inopathy, age-related macular degen- tions in Arcadia, Orange County, and eration, and retinal venous occlusive Pasadena. disease. In addition, Dr. Ip has served as the national director for numerous NIH-funded ophthalmic clinical trials.

56 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Ram Kannan, PhD M. Ali Khan, MD Olivia L. Lee, MD

Adjunct Professor of Ophthalmology Assistant Professor of Ophthalmology Health Sciences Assistant Clinical Professor of Ophthalmology Eye Physiology and Pathology Vitreoretinal Disease Cornea/External Diseases and Dr. Kannan’s research focuses on eye Dr. Khan’s clinical interests include the Uveitis; Corneal Imaging physiology and pathology. He cur- medical and surgical treatment of reti- rently investigates age-related mac- nal disease. He has a special interest in Focusing on cornea/external diseases ular degeneration, a leading cause of complex retinal surgery and the evalu- and uveitis, Dr. Lee’s particular interest blindness in high-resource countries. ation of novel surgical techniques and is in inflammatory ocular surface dis- technology, including research aiming ease, corneal melts, pterygia, and ante- to improve outcomes of retinal detach- rior segment complications of uveitis. ment repair. Dr. Lee performs all types of corneal Dr. Khan provides clinical care at the transplants, as well as complex cata- Doheny Eye Center UCLA–Pasadena, ract surgery in uveitic eyes. the Doheny Eye Center UCLA–­Arcadia, Dr. Lee’s research interests are ante- and the Stein Eye Center–Santa Monica. rior segment imaging applied to the tear film, cornea, and conjunctiva. With her expertise in corneal imaging, a specular microscopy reading center was developed at the Doheny Image Reading Center, where she serves as an investigator. Dr. Lee provides patient care at the Doheny Eye Center UCLA loca- tions in Arcadia, Orange County, and Pasadena.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 57 Kenneth L. Lu, MD Peter A. Quiros, MD Daniel B. Rootman, MD, MS

Health Sciences Assistant Clinical Health Sciences Associate Clinical Karen and Frank Dabby Endowed Chair Professor of Ophthalmology Professor of Ophthalmology in Ophthalmology* Medical Director, Assistant Professor of Ophthalmology Doheny Eye Center UCLA–Arcadia Neuro-Ophthalmology A neuro-ophthalmologist, Dr. Quiros Orbit and Ophthalmic Cataract and Refractive Surgery specializes in optic nerve disease, Plastic Surgery Dr. Lu specializes in cataract and refrac- including optic neuritis and multiple Dr. Rootman is an orbit and ophthalmic tive surgery, and his research activities sclerosis; double vision and adult plastic surgery specialist with exper- are focused in the same areas. strabismus; eye pain, headache, and tise in Graves disease, orbital surgery, Dr. Lu sees patients at the Doheny idiopathic intracranial hypertension; orbital tumors, ptosis, lacrimal disorders, Eye Center UCLA–Arcadia. Graves disease; orbital inflammatory blepharoplasty, blepharospasm, Botox®, syndromes; and stroke. Research cosmetic dermal fillers, endoscopic eye- includes idiopathic intracranial hyper- brow lift, eyelid surgery, eyelid tumors, tension, headache, ocular myasthenia and trauma. His research is developing gravis, Graves disease, optic neuri- and refining patient-­centered outcome tis and multiple sclerosis, and visual measures for surgical care; randomized rehabilitation after stroke. He was the clinical trials in surgery, including ptosis, principal investigator for the idiopathic Graves orbitopathy and lacrimal disease; intracranial hypertension treatment health economics of eyelid and facial trial and is the principal investigator for surgery; sociodemographics of facial the longitudinal idiopathic intracranial trauma; physiology and pathobiology hypertension treatment trial. He is a of ptosis; new approaches to surgery; member of the Neuro-Ophthalmology and measurement and assessment in Researcher and Disease Investigators medical education. Consortium. Dr. Rootman sees patients at the Dr. Quiros sees patients at the Stein Eye Institute in Westwood and the Doheny Eye Center UCLA locations Doheny Eye Center UCLA locations in in Orange County and Pasadena. Orange County and Pasadena.

*pending

58 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues SriniVas R. Sadda, MD Alfredo A. Sadun, MD, PhD Deming Sun, MD

Professor of Ophthalmology Professor of Ophthalmology Professor of Ophthalmology Stephen J. Ryan-Arnold and Flora L. Thornton Endowed Chair Mary D. Allen Chair in Vision Research Mabel Beckman Foundation in Vision Research Endowed Presidential Chair Vice Chair of Ophthalmology, Research Scientist President and Chief Scientific Officer, Doheny Eye Center UCLA Doheny Eye Institute Dr. Sun is a researcher whose primary Neuro-Ophthalmology areas of investigation include uveitis, Retinal and Macular Diseases autoimmune diseases, optic neuri- Clinical specialties of Dr. Sadun include tis, animal disease models, and T-cell Dr. Sadda received his MD from Johns neuro-ophthalmology, optic nerve, optic biology. Hopkins University, where he also com- neuropathies (eg, posterior is­che­mic pleted his ophthalmology residency optic neuropathy, anterior ischemic optic and neuro-ophthalmology and medical neuropathy, and traumatic optic neurop- retina fellowships. His clinical interests athy), Leber hereditary optic neuropathy, are macular degeneration and diabetic toxic and nutritional optic neuropathies, retinopathy and his research includes vision in Alzheimer’s, AIDS, and other automated retinal image analysis and central nervous system disorders. Dr. advanced retinal imaging technologies. Sadun’s research activities focus on He has more than 430 peer-reviewed human visual neuroanatomy; retinal publications and 20 book chapters, ganglion cell degeneration and regen- and has given over 400 presentations eration; axon populations in the human worldwide. He also serves as an edi- optic nerve in development, aging, torial board member of Ophthalmic and disease; and mitochondrial impair- Surgery, Lasers & Imaging, Retina, ments as a cause of optic neuropathy Graefe’s, Ophthalmology Retina, and and other forms of neurodegeneration. Ophthalmology. He is also an editor Dr. Sadun sees patients at the of the 5th edition of the Ryan’s Retina Doheny Eye Center UCLA–Pasadena. textbook. Dr. Sadda provides clinical care at the Doheny Eye Center UCLA in ­Pasadena and Arcadia.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 59 James C. Tan, MD, PhD Yuhua Zhang, PhD

Associate Professor of Ophthalmology Associate Professor of Ophthalmology

Glaucoma Retinal Imaging Dr. Tan is a dual fellowship-trained Dr. Zhang is an optical engineer and ret- glaucoma specialist. He treats the full inal imaging specialist, whose research spectrum of cataract and glaucoma encompasses state-of-the-art tools to conditions, ranging from mild to com- study blinding eye disorders, including plex. His treatments and surgeries next-generation 3-D imaging technol- focus on safe and effective outcomes ogy for viewing the retina in patients using advanced techniques. Dr. Tan has with age-related macular degeneration authored over 100 scientific papers, at the cellular level. abstracts, book chapters, and books. His technology integrates adaptive His glaucoma research addresses optics, scanning laser ophthalmoscopy, advanced imaging, molecular patho- and optical coherence tomography to genesis, drug development, and surgi- study the vision-producing cells and cal techniques. He has received awards tiniest blood vessels of the eye. Under- from the National Institutes of Health, standing their interplay will help answer Research to Prevent Blindness, and the questions about causes of vision loss, American Glaucoma Society. improve prognoses for patients, and Dr. Tan provides patient care at the lead to directed treatments to slow or Doheny Eye Center UCLA locations in prevent vision loss. Arcadia and Pasadena.

60 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues ACADEMIC PERSONNEL

Stein Eye Institute Members Antoni Ribas, MD Professional Research Series Based at Other Sites Professor of Medicine, Surgery, and Molecular and Medical Pharmacology Christian Altenbach, PhD Malignant Melanoma James W. Bisley, PhD Research Ophthalmologist Dr. Ribas is a physician-scientist who Associate Professor of Neurobiology Structure and Function and Psychology conducts laboratory and clinical re- of Rhodopsin Member of the Brain Research Institute search in malignant melanoma, focus- ing on gene engineered adoptive cell The membrane protein rhodopsin is a Cognitive Processing of transfer (ACT) therapies, anti-CTLA4 critical first step in visual transduction, Visual Information antibodies, anti-PD-1 antibodies, and converting light energy into a chemical Dr. Bisley’s research revolves around BRAF and MEK inhibitors. form in the photoreceptor cell of the understanding the neural mechanisms eye. To understand this process on underlying the cognitive processing a detailed molecular level, Dr. Alten- of visual information. These cognitive Dario L. Ringach, PhD bach is using site-directed spin labeling processes include visual perception, Professor of Neurobiology and electron paramagnetic resonance visual memory, and visual attention. and Psychology, spectroscopy to study the structure Biomedical Engineering Program Recent work has focused on how the of rhodopsin in the absence of light, responses of neurons in the poste- Visual Perception as well as the changes in structure rior parietal cortex are involved in the and Neurophysiology caused by light. allocation of visual attention to neu- Dr. Ringach’s research focuses on the rons in visual cortices and how they relationship between eye movements guide eye movements in goal-directed Michael Bridges, PhD and visual perception, as well as how visual search. Assistant Project Scientist motor planning and execution, such as reaching, grasping, navigating, and Paramagnetic Resonance Methodologies Patrick T. Dowling, MD, MPH adjusting body posture, is influenced by visual information and impaired Chair, UCLA Department of Dr. Bridges’ research in the laboratory Family Medicine vision. In collaboration with a team of of Dr. Wayne Hubbell is centered on neurosurgeons at UCLA, Dr. Ringach’s The Kaiser Endowed Professor of the development and application of Community Medicine laboratory is also recording the brain new pulsed electron paramagnetic activity of patients with epilepsy who resonance methodologies. Protein con- Health Care Policy and Access for are undergoing clinical evaluation for formational dynamics and structural Underserved Populations surgical treatment, shedding new light relaxation are his central focus with the Dr. Dowling has received grant funding into the processes involved in object goal of characterizing the timescales for more than 30 years to link medi- recognition and perception. and motional amplitudes of functional cal education to underserved neigh- activation. borhoods thereby providing access to care. Further, he has worked with Dr. Anne Coleman and the Care Harbor Barry L. Burgess, BS program to provide free medical, den- Research Specialist tal, and eye care to 3,500 low-income Degenerative Retinal Disease families, and the medically indigent of Research Los Angeles. Mr. Burgess provides research support for the Photoreceptor/RPE Cell Biol- ogy Laboratory of Dr. David Williams. Research interests include production of differentiated RPE cells from human stem cell precursors and develop- ing in vitro models of oxidative stress involved in degenerative retinal dis- ease progression.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 61 Doug Chung, PhD Rajendra Gangalum, PhD Joanna J. Kaylor, PhD Assistant Project Scientist Assistant Research Specialist Associate Project Scientist Corneal Endothelial Dystrophies Function and Regulation of Visual Chromophore Regeneration Small Heat Shock Protein in the Retina of the Eye Dr. Chung’s research focus is eluci- aB-crystallin in Health and Disease dating the mechanisms involved in Dr. Kaylor has discovered that light the pathogenesis of inherited corneal Dr. Gangalum’s research seeks to gain plays a vital role in regeneration of endothelial dystrophies in an effort to understanding of the physiological visual chromophore in the retina. She develop novel gene-based therapeutic function of aB-crystallin in the devel- recently identified a non-enzymatic approaches. oping ocular lens and non-ocular tis- process that generates visual pigment sues. aB-crystallin has been shown in photoreceptor membranes in light. to associate with pathologies such as Her research now focuses on the func- Matthias Elgeti, PhD cataracts, cancer, age-related macular tion of retinal G-protein coupled recep- Assistant Project Scientist degeneration, and various neurode- tor (RGR). generative diseases. Development of Common Structure/Function Relationships Jacky M. K. Kwong, PhD of GPCR Activation Based on the Sheyla Gonzalez, PhD Rhodopsin Model System Research Ophthalmologist Assistant Project Scientist Dr. Elgeti’s work focuses on the activa- Degeneration of Retinal Ganglion Limbal Stem Cells Cells and Neuroprotection tion mechanisms of G protein coupled receptors (GPCRs), which are involved Dr. Gonzalez´s research aims to improve Dr. Kwong identifies novel neuropro- in many cellular signaling processes the ex vivo expansion of limbal epithe- tective and regenerative therapies for and represent major drug targets. He lial stem cells (LSCs) by modulating glaucoma that preserve and restore addresses his questions by comparing Notch signaling in individuals suffering the nerve cells. He utilizes animal mod- visual rhodopsin with other prototypical from limbal stem cell deficiency. The els related to optic nerve injury and GPCRs using site-directed spin label- identification of niche factors could glaucoma to understand the progres- ing (SDSL) and electron paramagnetic help to improve the in vitro production sion of retinal ganglion cell degener- resonance (EPR) spectroscopy. of LSCs for transplantation. ation, and pharmacologic techniques and functional assessments to eval- uate therapies. Rikard Frederiksen, PhD Sonia Guha, PhD Assistant Research Ophthalmologist Assistant Project Scientist Anna Matynia, PhD Adaptation Unraveling New Therapeutic Associate Research Ophthalmologist Targets for Ocular Albinism Dr. Frederiksen’s main research inter- Mechanisms Underlying est is adaptation, specifically how the Dr. Guha studies genes that may be Photoallodynia rods and cones in the retina adapt to associated with the misrouting of retinal different light intensities. ganglion cell (RGC) axons at the brain’s Dr. Matynia’s research investigates optic chiasm in individuals affected with the mechanisms underlying photo­ X-linked ocular albinism type 1 (OA1). allo­dynia, a condition in which normal This disease is also characterized by levels of light produce or enhance hypopigmentation and presence of ocular or headache pain. Using behav- macromelanosomes in the RPE. How ioral, molecular, genetic, and cellular the reduced pigmentation of OA1 RPE approaches, the laboratory focuses exerts its effects on the RGCs to influ- on corneal, retinal, and central mecha- ence the misrouting of their axons at nisms from dry eye injury, achromatop- the optic chiasm remains unsolved, and sia, and migraine, respectively. Dr. Guha’s findings have the potential to unravel new therapeutic targets for OA1.

62 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Alberto C. Ruiz-Morales Professional Clinical Series Research Specialist Visual Cycle Laura Bonelli, MD Mr. Ruiz, a molecular biologist, is directly Associate Physician Diplomate involved in the cloning and charac- Neuro-Ophthalmology terization of enzymes critical for the proper functioning of the visual cycle. Dr. Bonelli provides clinical supervision Currently, Mr. Ruiz is analyzing genes, to resident physicians at the Univer- such as ARMS2 and HTRA1, which are sity Ophthalmology Associates and thought to be involved in age-related teaches medical students during their macular degeneration. ophthalmology surgical subspecial- ties clinical rotation. She is collabo- rating on a study to learn and better Alejandra Young, PhD understand giant cell arteritis (GCA), an Assistant Project Scientist inflammation of the lining of the arter- Ocular Albinism ies. GCA frequently causes blurred or double vision, and if left untreated, Uday Devgan, MD, FACS, Dr. Young’s research is focused on the may result in loss of vision. She is also FRCS study of the molecular mechanisms that a co-­investigator for the National Eye Clinical Professor of Ophthalmology cause ocular albinism type 1 (OA1 ), a dis- Institute-sponsored study of idiopathic Chief of Ophthalmology, Olive View- ease caused by mutations in the OA1 intracranial hypertension. UCLA Medical Center gene and characterized by hypopig- Dr. Devgan is a cataract and refractive mentation of the retinal pigment epithe- surgery specialist who has taught oph- lium and abnormal crossing of the optic Melissa W. Chun, OD thalmic surgery in more than 50 coun- axons at the optic chiasm. In addition, Associate Clinical Professor tries. He has been actively involved she investigates the potential therapeu- of Ophthalmology in resident teaching for nearly two tic use of engineered human embryonic Director of the UCLA decades, and he has mentored more stem cell-derived extracellular vesicles Vision Rehabilitation Center than 130 residents over the course of for the treatment of ocular albinism. Vision Rehabilitation thousands of ocular surgeries, includ- Dr. Chun’s clinical research interests ing advising former residents after the are in vision rehabilitation outcomes culmination of their training. Passionate and training techniques that maximize about teaching the next generation of visual function. She is a member of the ophthalmologists, Dr. Devgan has been Low Vision Research Network, a nation- honored with the ophthalmol­ogy Fac- wide collaboration of low vision spe- ulty Teaching Award an unprecedented cialists for multicenter clinical studies. four times. She is also involved in visual outcome measures for various clinical studies on macular degeneration.

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 63 Rachel Feit-Leichman, MD Phillip Le, MD, PhD Susan S. Ransome, MD Associate Physician Diplomate Associate Physician Diplomate Associate Physician Diplomate Cataract Surgery Retinal and Macular Diseases Clinical Instructor of Ophthalmology Dr. Feit-Leichman divides her time Dr. Le is a comprehensive ophthalmolo- HIV and Diabetic Retinopathy between supervising residents and gist who specializes in retinal and mac- Dr. Ransome is participating in a clinical providing patient care at the Stein ular diseases. He sees patients at the research study involving HIV-­infected Eye Institute’s Urgent Care Clinic, and Doheny Eye Center UCLA–Pasadena. patients who have diabetes to see teaching cataract surgery and over- whether there is increased risk of devel- seeing residents at the ophthalmol- opment or progression of diabetic reti- ogy clinic of the Harbor-UCLA Medical Mitra Nejad, MD nopathy when subjects are treated for Center. Dr. Feit-Leichman is also active Associate Physician Diplomate abdominal lipodystrophy with Egrifta in striving to improve patient access to Clinical Instructor of Ophthalmology (tesamorelin). eye care in the greater Los Angeles Comprehensive Ophthalmology County Healthcare System. Dr. Nejad practices comprehensive Meryl L. Shapiro-Tuchin, MD ophthalmology at the Stein Eye Insti- Associate Physician Diplomate Batool Jafri, MD tute and the Stein Eye Center–Santa Assistant Clinical Professor Associate Physician Diplomate Monica. Her practice involves general of Ophthalmology Assistant Clinical Professor ophthalmic care, as well as cataract and Co-Director of the Ophthalmology of Ophthalmology refractive surgery. In addition, Dr. Nejad Inpatient Consultation Service teaches UCLA medical students and Cornea/External Disease/ Comprehensive Ophthalmology Refractive Surgery residents at the Stein Eye Institute, as well as supervising resident cata- Dr. Shapiro-Tuchin provides clinical Dr. Jafri provides patient care as well ract surgery at Harbor-UCLA Medi- supervision to resident physicians. as supervision to resident physicians cal Center. She functions as co-director of the and cornea fellows. Her focus is med- Ophthalmology Inpatient Consultation ical and surgical treatment of diseases Service, assisting resident physicians in of the cornea, external disease, and Tania Onclinx, MD their evaluation of inpatients admitted refractive conditions like near and far Associate Physician Diplomate to the Ronald Reagan UCLA Medical sightedness. She also provides gen- Clinical Instructor of Ophthalmology Center and the UCLA Medical Center, eral ophthalmic care and offers cata- Santa Monica. ract surgery with premium intraocular Urgent Care and Clinical lens implants. Supervision Dr. Onclinx attends at the Urgent Care Ronald J. Smith, MD Monica R. Khitri, MD Walk-In service at the Stein Eye Insti- Associate Physician Diplomate tute, and she teaches resident phy- Associate Clinical Professor Associate Physician Diplomate sicians and medical students at the of Ophthalmology Pediatric Ophthalmic Diseases Stein Eye Institute during their subspe- Objective Assessment of Surgical and Strabismus cialty clinical rotation. She also provides Technique and Training clinical supervision to resident physi- Dr. Khitri specializes in the evaluation cians at Ronald Reagan UCLA Medi- Dr. Smith’s research interest is the and treatment of pediatric ophthalmic cal Center and UCLA Medical Center, objective assessment of surgical tech- diseases, including pediatric cataracts, Santa Monica. nique and development of evidence- nasolacrimal duct obstructions, ambly- based surgical training for residents opia, and retinopathy of prematurity. to improve patient care. In addition She also treats and operates on stra- to teaching residents at the Veterans bismus in both children and adults. Affairs Greater Los Angeles Healthcare Dr. Khitri sees patients at the Doheny System and in the UCLA Microsurgery Eye Center UCLA locations in Arca- Laboratory, Dr. Smith provides cornea dia and Pasadena. She also teaches and comprehensive eye care to patients residents and fellows at Harbor-UCLA at the Stein Eye Center–Santa Monica. Medical Center, where she is chief of the pediatric ophthalmology service.

64 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Laura A. Syniuta, MD Associate Physician Diplomate Pediatric Ophthalmology and Strabismus Dr. Syniuta completed her fellowship training in pediatric ophthalmology and strabismus at the Stein Eye Institute in 1999. With children’s eye and learn- ing disorders being her passion, she sees patients at the Stein Eye Center– Santa Monica and has staffed the UCLA Mobile Eye Clinic since 2011.

Federico G. Velez, MD Associate Physician Diplomate Strabismus and Childhood Eye Disorders Dr. Velez’s primary research interest is studying the mechanisms of congenital and acquired forms of strabismus. He has participated in the development of guidelines for preoperative assessment and surgical approaches to patients with convergent (esotropia), divergent (exotropia), and vertical forms of stra- bismus, and has developed new tech- niques to treat pediatric patients with eyelid abnormalities and cataracts.

Victoria Yom, MD Associate Physician Diplomate

LECTURER Kathleen L. Boldy, VMD Lecturer in Ophthalmology

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 65 UCLA DEPARTMENT OF OPHTHALMOLOGY VOLUNTEER FACULTY

Volunteer Faculty ASSOCIATE CLINICAL PROFESSORS ASSISTANT CLINICAL PROFESSORS OF OPHTHALMOLOGY OF OPHTHALMOLOGY Gerrald Barron, MD (Senior Status) David H. Aizuss, MD CLINICAL PROFESSORS Arnold Barton, MD (Senior Status) OF OPHTHALMOLOGY Malvin B. Anders, MD Kevin J. Belville, MD Richard K. Apt, MD J. Bronwyn Bateman, MD Louis Bernstein, MD (Senior Status) Reginald G. Ariyasu, MD, PhD Bruce B. Becker, MD, PC W. Benton Boone, MD Arthur A. Astorino, MD Michael S. Berlin, MD Harvey Brown, MD Mark A. Baskin, MD William P. Chen, MD Andrew E. Choy, MD Arthur Benjamin, MD Paul Deiter, MD (Senior Status) Melissa W. Chun, OD Katherine L. Bergwerk, MD Uday Devgan, MD, FACS, FRCS Peter J. Cornell, MD Chief of Ophthalmology Betsy E. Blechman, MD Olive View-UCLA Medical Center Bernard Davidorf, MD (Senior Status) Cynthia A. Boxrud, MD Donald Dickerson, MD (Senior Status) Paul B. Donzis, MD Amarpreet S. Brar, MD Donald S. Fong, MD, MPH Kathryn M. Gardner, MD Almira W. Cann, MD, PhD Leland M. Garrison, MD Donald I. Goldstein, MD Arnett Carraby, MD Thomas A. Hanscom, MD Michael J. Groth, MD Vicki K. Chan, MD John D. Hofbauer, MD Andrew Henrick, MD Andrew M. Chang, MD Kenneth J. Hoffer, MD Edwin P. Hill, MD Candice Chen, MD C. Richard Hulquist, MD Jonathan A. Hoenig, MD Thomas B-H. Choi, MD Barry M. Kerman, MD Richard H. Hoft, MD Milton W. Chu, MD Roger A. Kohn, MD David F. Kamin, MD Robert A. Clark, MD Howard R. Krauss, MD Stanley Kopelow, MD (Senior Status) Charles A. Cooper, MD Benjamin C. Kwan, MD Joseph Lambert, MD (Senior Status) Hajir Dadgostar, MD Jeremy Levenson, MD (Senior Status) Brian L. Lee, MD Yadavinder P. Dang, MD Jonathan I. Macy, MD Steven Leibowitz, MD Jonathan M. Davidorf, MD Ezra Maguen, MD Gene Matzkin, MD (Senior Status) John L. Davidson, MD Robert K. Maloney, MD Joan E. McFarland, MD Sanford S. Davidson, MD Samuel Masket, MD James McKinzie, MD (Senior Status) Louise Cooley Davis, MD Leon G. Partamian, MD Alan Norton, MD (Senior Status) Farid Eghbali, OD George Primbs, MD (Senior Status) John F. Paschal, MD (Senior Status) Troy R. Elander, MD Yaron S. Rabinowitz, MD Firas Rahhal, MD Naomi L. Ellenhorn, MD Teresa O. Rosales, MD George M. Rajacich, MD Calvin T. Eng, MD Robert J. Schechter, MD (Senior Status) Michael Reynard, MD Robert E. Engstrom, MD Stephen Seiff, MD (Senior Status) David S. Robbin, MD Doreen T. Fazio, MD Alan L. Shabo, MD David E. Savar, MD Sanford G. Feldman, MD Norman Shorr, MD Timothy V. Scott, MD Laura E. Fox, MD Roger W. Sorenson, MD (Senior Status) Kayur Shah, MD Ronald P. Gallemore, MD Albert Sheffer, MD George H. Garcia, MD James D. Shuler, MD Leslie C. Garland, MD (Senior Status) Yossi Sidikaro, MD, PhD W. James Gealy, Jr., MD Matthew Sloan, MD Damien Goldberg, MD Ronald J. Smith, MD Lawrence “Tim” Goodwin, MD Alfred Solish, MD, MS Lawrence H. Green, MD (Senior Status) Kenneth D. Steinsapir, MD Richard Havunjian, MD Sadiqa Stelzner, MD, MA, FACS Man M. Singh Hayreh, MD William C. Stivelman, MD (Senior Status) Matthew L. Hecht, MD Hector L. Sulit, MD David A. Hollander, MD Kamal A. Zakka, MD Jeffrey Hong, MD

66 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Catherine J. Hwang, MD, MPH Barry S. Seibel, MD CLINICAL INSTRUCTORS Morton P. Israel, MD Meryl Shapiro-Tuchin, MD IN OPHTHALMOLOGY Steven J. Jacobson, MD David M. Shultz, MD Eduardo Besser, MD Batool Jafri, MD Eliot B. Siegel, MD Maria Braun, MD Aarchan Joshi, MD Lance M. Siegel, MD Stephen S. Bylsma, MD Véronique H. Jotterand, MD John D. Slaney, MD Andrew Caster, MD Jason Jun, MD Robert J. Smyth, MD John J. Darin, MD (Senior Status) Ganesha Kandavel, MD Kenneth O. Sparks, MD Paul J. Dougherty, MD J. David Karlin, MD Mehryar “Ray” Taban, MD, FACS Sean Dumars, MD David S. Katzin, MD Homayoun Tabandeh, MD Daniel Ebroon, MD James F. Kleckner, MD (Senior Status) Robert C. Tarter, MD Brad S. Elkins, MD Jerome R. Klein, MD Debra G. Tennen, MD Nicole Fram, MD Craig H. Kliger, MD Teddy Y. Tong, MD Satvinder Gujral, MD Howard E. Lazerson, MD (Senior Status) Sterling M. Trenberth, MD Lawrence M. Hopp, MD, MS Robert T. Lin, MD (Senior Status) Anisha J. Judge, MD Joanne E. Low, MD Robert C. Tudor, MD (Senior Status) Ganesha Kandavel Bryant J. Lum, MD Henry E. Ullman, MD Michael Kapamajian Michael C. Lynch, MD Tay J. Weinman, MD (Senior Status) Rajesh Khanna, MD M. Polly McKinstry, MD Irwin S. Weiss, MD (Senior Status) Julie A. King, MD Ashish M. Mehta, MD Sidney J. Weiss, MD Mark H. Kramar, MD Kenneth J. Miller, MD (Senior Status) Scott Whitcup, MD Daniel Krivoy, MD David R. Milstein, MD David L. Williams, MD (Senior Status) Laurie C. McCall, MD Ronald L. Morton, MD Jeffrey V. Winston, MD Mitra Nejad, MD Roger L. Novack, MD, PhD David M. Winters, MD (Senior Status) Jayantkumar Patel, MD David Paikal, MD David L. Wirta, MD Susan S. Ransome, MD Alpa A.S. Patel, MD Barry J. Wolstan, MD Steven H. Rauchman, MD James H. Peace, MD Wilson C. Wu, MD, PhD Richard H. Roe, MD Gilbert Perlman, MD (Senior Status) Michael C. Yang, MD Louis M. Savar, MD Cheryl J. Powell, MD Patrick C. Yeh, MD Vivian Shibayama, OD John R. Privett, MD (Senior Status) Richard H. Yook, MD (Senior Status) Abraham Soroudi, MD Laurence N. Roer, MD Andrew Young, MD Sharon N. Spooner-Dailey, MD Gerald Sanders, MD (Senior Status) Peter D. Zeegen, MD (Senior Status) Laura A. Syniuta, MD Aaron M. Savar, MD Rosalind Vo, MD Mark Volpicelli, MD Mathew Wang, MD Peter H. Win, MD

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 67 CONSULTING MEMBERS OF STEIN EYE INSTITUTE EMERITUS FACULTY THE STEIN EYE INSTITUTE

Robert W. Baloh, MD Dean Bok, PhD Professor of Neurology and Surgery (Head and Neck) Dolly Green Chair of Ophthalmology Professor of Ophthalmology Emeritus Ferdinand V. Coroniti, PhD (Active Recall) Professor, Department of Physics Distinguished Research Professor of and Astronomy Neurobiology David Eisenberg, DPhil Member of the Brain Research Institute Investigator, Howard Hughes Medical Institute Paul D. Boyer Professor of Biochemistry Richard Casey, MD and Molecular Biology Health Sciences Clinical Professor Emeritus Professor, Departments of Chemistry and Biochemistry, and Biological Chemistry Gordon L. Fain, PhD Molecular Biology Institute Distinguished Professor of the Bradley R. Straatsma, MD, Alan M. Fogelman, MD Departments of Integrative Biology/Physiology and of Castera Professor and Executive Chair JD Ophthalmology (Active Recall) Department of Medicine Professor of Ophthalmology Emeritus Founding Chair of the Department of Alan D. Grinnell, PhD Ophthalmology Professor of Physiology and Michael O. Hall, PhD Physiological Science Professor of Ophthalmology Emeritus Founding Director of the Stein Eye Institute Director, Jerry Lewis Neuromuscular Founding Member of the Stein Eye Research Center Institute Director, Ahmanson Laboratory of Neurobiology Robert S. Hepler, MD Barry A. Weissman, OD, PhD C. Kumar Patel, PhD Professor of Ophthalmology Emeritus Professor of Ophthalmology Emeritus Professor, Department of Physics Founding Chief of the Neuro- and Astronomy Ophthalmology Division Marc O. Yoshizumi, MD Leonard H. Rome, PhD Senior Associate Dean for Research Professor of Ophthalmology Emeritus Professor of Biological Chemistry Joseph Horwitz, PhD Distinguished Professor of Peter C. Whybrow, MD Ophthalmology Judson Braun Professor and (Active Recall) Executive Chair Department of Psychiatry and Biobehavioral Sciences Allan E. Kreiger, MD Director and Physician in Chief Neuropsychiatric Institute Professor of Ophthalmology Emeritus (Active Recall) Founding Chief of the Retina Division

68 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues RESIDENTS AND FELLOWS

Residents Fellows International Fellows

THIRD-YEAR RESIDENTS Cornea/External Ocular Diseases Cornea Research 2016–2019 and Refractive Surgery Turad Alkadi, MD Christine L. Bokman, MD Nathan Abraham, MD Saudi Arabia Benjamin C. Campbell, MD Amir Hossein Marvasti, MD Clémence Bonnet, MD France Elisha C. Garg, MD Anjali Tapadia, MD (Doheny Eye Center UCLA) Seyed Reza Ghaffari Dehkharghani, MD Kirk K. Hou, MD Iran Patrick J. Lee, MD Glaucoma Xiongfei Lu, MD Christine Petersen, MD Comprehensive Ophthalmology/ Eric Shieh, MD Aleksandr Yelenskiy Cataract Victoria L. Tseng, MD, PhD (EyeSTAR) (Doheny Eye Center UCLA) None Jonathan Young, MD SECOND-YEAR RESIDENTS Glaucoma 2017–2020 Medical Retina and Qiang Fu, MD China Judd Cahoon, MD Ophthalmic Genetics Golnoush Mahmoudi Nezhad, MD Tamara L. Lenis, MD, PhD (EyeSTAR) Giovanni Greaves, MD Iran Cameron Pole, MD Terry Wood, MD Vahid Mohammadzadeh, MD David T. Stark, MD, PhD (EyeSTAR) Neuro-Ophthalmology Iran William Stoddard, MD None Alessandro Rabiolo, MD Sandip Suresh, MD Italy Qing Wang, MD, PhD (EyeSTAR) Orbital and Ophthalmic Diana Salazar Vega, MD Madeline Yung, MD Plastic Surgery Colombia Justin Karlin, MD Xiaobin Xie, MD FIRST-YEAR RESIDENTS Christopher Lo, MD (Doheny Eye Center UCLA) 2018–2021 China Michael DaSilva, MD Pathology (Eye) Medical Retina and Eliot Dow, MD None Ophthalmic Genetics Nicholas Iafe, MD Pediatric Ophthalmology M. Zubair Yameen Arain, MD Jaffer Kattan, MD and Strabismus Pakistan Anh Pham, MD, PhD (EyeSTAR) Lindsay De Andrade, MD Giulia Corradetti, MD Ernest Puckett, MD Jennifer Pan, MD Italy Austin Woolley, MD Assaf Hilely, MD Andrea Yonge, MD Uveitis and Inflammatory Israel Eye Disease Mee Yon Lee, MD None South Korea EyeSTAR Trainees Vitreoretinal Diseases and Surgery Neuro-Ophthalmology Adrian Au, MD Wei Gui, MD Stacey Marie Cohitmingao, MD Sarah Cheng, MD Jason “Mingyi” Huang, MD Philippines Tamara L. Lenis, MD Nikisha Kothari, MD Uchenna Francis Nwako, MD Nigeria Anh H. Pham, MD, PhD Niranjan Manoharan, MD David Stark, MD, PhD Orbital and Ophthalmic Michel Sun, MD, PhD Plastic Surgery Victoria Tseng, MD, PhD Bunyada Putthirangsiwong, MD Qing Wang, MD, PhD Thailand

Faculty and Colleagues | UCLA STEIN EYE INSTITUTE 69 Pediatric Ophthalmology Predoctoral Postdoctoral Toshiaki Goseki, MD, PhD Research Fellows Research Fellows Japan Kevin Eden Edouard Baulier, PhD Uveitis W. Blake Gilmore Abhishek Chadha, PhD None Khristopher Griffis Aurelie Dos Santos, PhD Roni Hazim Antonio Escudero Paniagua, PhD Visual Physiology Norianne Ingram Nermin Kady, PhD None Margaux Kreitman Ala Morshedian, PhD Vitreoretinal Diseases and Surgery Alan Le Jonathan Rodriguez, PhD Ismael Chehaibou, MD Eunice Ng Charles Avery Sader, PhD France Joseph Park Ankita Umapathy, PhD Gilad Rabina, MD Katie Pohl Yanjie Wang, PhD Israel Gabriel Pollock Chi Zhang, PhD Aditya Verma, MD Gabriela Sendek Wenlin Zhang, MD, PhD (Doheny Eye Center UCLA) Tongzhou Xu India

70 UCLA STEIN EYE INSTITUTE | Faculty and Colleagues Research and Funding Research Contracts and Grants

Vision-Science Research Sophie X. Deng, MD, PhD Joseph Horwitz, PhD Development of Stem Cell-based Analysis of Lens Crystallins and Active Funding Therapies for Limbal Stem Cell Cataractous Mutants at Deficiency High Hydrostatic Pressure ADMINISTERED BY THE National Eye Institute National Eye Institute STEIN EYE INSTITUTE Duration: 2/1/19–1/31/24 Duration: 4/1/14–3/31/20 $250,000 $150,000 Faculty Development of Small-Molecule Wnt Alex A. Huang, MD, PhD Mimetics for Corneal Epithelial Cell Discovery and Characterization of Anthony J. Aldave, MD Regeneration Anterior Sclera Pathology in Glaucoma In Vitro Expansion of HCEnC Using National Eye Institute (Multi-PI with Jie J. National Eye Institute Differing Cell Cultural Systems Zheng, PhD) Duration: 9/30/14–9/29/19 Eye Bank Association of America Duration: 9/30/18–8/31/22 $203,981 Duration: 7/1/18–6/30/19 $292,577 $5,000 Research to Prevent Blindness Career Gordon L. Fain, PhD Development Award Suraj P. Bhat, PhD Physiology of Photoreceptors Research to Prevent Blindness, Inc. Childhood Cataractogenesis: National Eye Institute Duration: 1/1/16–12/31/19 Heterogeneity of Gene Expression Duration: 8/1/17–7/31/21 $75,000 National Eye Institute $250,000 Duration: 1/1/15–12/31/19 Wayne L. Hubbell, PhD Visual Integration in the Retina of the $329,180 Molecular Basis of Membrane Excitation Sea Lamprey Petromyzon Marinus National Eye Institute Great Lakes Fishery Commission Ava K. Bittner, OD Duration: 5/1/15–4/30/20 Duration: 1/1/19–12/31/21 Beacon Sensors and Telerehabilitation $311,375 to Assess and Improve Use of Devices $73,562 for Visual Functioning (BeST-AID) Jean-Pierre Hubschman, MD Debora B. Farber, PhD, DPhhc National Eye Institute Vitreoretinal Surgery via Robotic Patient-derived iPSCs, CRISPR/Cas Duration: 2/1/19–1/31/21 Microsurgical System with Image and RPE-derived Exosomes for the $185,212 Guidance, Force Feedback, Virtual Treatment of Ocular Albinism Fixture, and Augmented Reality Vision of Children Joseph Caprioli, MD National Eye Institute Duration: 6/1/16–12/31/20 Clinical Research Program in Glaucoma Duration: 2/1/19–1/31/24 $157,484 Simms-Mann Family Foundation $307,120 Duration: 7/1/14–6/30/20 Michael B. Gorin, MD, PhD $50,000 Michael Ip, MD IPS Model for Retinal Hemangioma The SCORE 2 Long-Term Follow-Up Pathogenesis Anne L. Coleman, MD, PhD (SCORE2 LTF) VHL Family Alliance Ocular Hypertension Treatment Study National Eye Institute Duration: 10/1/16–9/30/18 20-Year Follow-up: Clinical Center Grant Sub-award from Pennsylvania State $50,000 National Eye Institute University Sub-award with Washington University Duration: 4/1/19–3/31/20 Gary N. Holland, MD Duration: 7/1/15–6/30/19 $46,143 $4,883 Systemic Immunosuppressive Therapy for Eye Diseases Studies of Comparative Treatments in Joseph L. Demer, MD, PhD Cohort Study (SITE) Retinal Vein Occlusion 2 (SCORE 2) Biomechanical Analysis in Strabismus University of Pittsburgh National Eye Institute Surgery Duration: 3/2/16–3/2/21 Sub-award from Pennsylvania State National Eye Institute Non-monetary Contract University Duration: 6/16/16–3/31/19 Duration: 5/1/16–4/30/20 Systemic Immunosuppressive Therapy $47,631 $385,668 for Eye Disease (Cancer Surveillance and Research Data-Driven Biomechanical Simulation Bartly J. Mondino, MD Branch/CCR) of Eye Movement and Strabismus RPB Unrestricted Grant University of Pittsburgh National Eye Institute Research to Prevent Blindness, Inc. Duration: 3/2/16–3/2/21 Sub-award from George Mason Duration: 1/1/12–12/31/19 Non-monetary Contract University $115,000 Duration: 6/1/19–5/30/20 $60,238

72 UCLA STEIN EYE INSTITUTE | Research and Funding Stacy L. Pineles, MD David S. Williams, PhD Professional Research Series Physical Injuries in Patients with The Photoreceptor Cilium Pediatric Eye Diseases National Eye Institute Sonia Guha, PhD National Eye Institute Duration: 5/1/13–4/30/20 Role of Doublecortin in Axonal Duration: 1/1/19–12/31/20 $250,000 Misrouting in OA1 -/- Mice $150,000 Vision of Children Photoreceptor Disk Membrane Duration: 7/1/14–3/15/20 RPB Walt and Lilly Disney Award for Morphogenesis $152,236 Amblyopia Research National Eye Institute Research to Prevent Blindness, Inc. Sub-award from University of California, Anna Matynia, PhD Duration: 7/1/14–12/31/19 Santa Barbara Targeted Hsp70 as a Therapeutic for $100,000 Duration: 4/1/15–3/21/20 Central Retinal Artery Occlusion $124,797 Rubicon Biotechnology Roxana Radu, MD Stein Eye Institute Core Grant for Vision Duration: 9/30/17–9/30/19 The Role of Complement in Recessive Research $40,400 Stargardt Disease National Eye Institute National Eye Institute Duration: 9/1/15–6/30/20 Alejandra Young, PhD Duration: 8/1/15–7/31/20 $500,000 Identification of the OA1 Molecule $250,000 Partners Critical for Axonal Guidance of Gene Editing of the Usher 1B Gene Identification of Bisretinoid Levels in RGCs Growth Cones Foundation Fighting Blindness ABca4-/-Mouse Retinas (Proposal Continuation of Grant Duration: 6/1/17–5/31/20 NightstaRx #20142326) $100,000 Duration: 9/26/18–9/25/19 Vision of Children $25,641 Cellular Mechanisms of Disease in Duration: 11/1/13–7/14/20 Patient-Specific RPE Cells $205,301 Alapakkam P. Sampath, PhD Foundation Fighting Blindness Molecular Basis of Photoreceptor Wiring Sub-award from University of California, Residents and Fellows National Eye Institute San Francisco (Multi-PI award with Scripps Clinic and Duration: 6/1/17–5/31/19 Abhishek Chadha, PhD Research Foundation) $164,930 (Vision-Science Postdoctoral Fellow) Duration: 5/1/17–4/30/22 Functional Characterization of MY07A in $92,598 RPE Cell Biology, Aging, and Disease National Eye Institute Retinal Tissue Analyses of Retinal Circuits After Rod Duration: 9/1/17–5/31/22 National Eye Institute Rescue in a Mouse Model of Human $596,846 Duration: 7/1/16–6/30/19 Blindness $61,174 National Eye Institute Delineating the Role of TIMP3 in (Multi-PI award with University of Macular Degeneration Wenlin Zhang, MD, PhD Southern California) University of Rochester Transcriptome Analysis of the Duration: 9/1/16–8/31/21 Duration: 7/1/18–6/30/19 Metabolic Reprogramming in SLC4A11 $95,673 $24,512 Associated Congenital Hereditary Endothelial Dystrophy Test of Readthrough Drug Treatment for Vision Science Training Program Knights Templar Eye Foundation, Inc. UGA PTC in the USH1B Gene National Eye Institute Duration: 7/1/17–12/31/18 Foundation Fighting Blindness Duration: 9/1/17–8/31/22 $65,000 $253,473 Duration: 1/1/19–12/31/21 $90,308 Molecular Mechanisms of Photoreceptor Adaptation Xian-Jie Yang, PhD National Eye Institute Neuroprotection Mechanism for Duration 2/1/19–1/31/24 Photoreceptors $267,551 National Eye Institute Duration: 5/1/16–4/30/21 Gabriel H. Travis, MD $366,660 Instrumentation Grant for Stein Eye Investigators Jie Zheng, PhD Bruce Ford and Anne Smith Bundy Development of Small-Molecule Wnt Foundation Mimetics for Corneal Epithelial Cell Duration: 8/16/11–8/15/19 Regeneration $100,000 National Eye Institute (Multi-PI with Sophie Deng, MD, PhD) Functional Characterization of RGR- Duration: 9/30/18–8/31/22 OPSIN in Retinal Müller Cells $292,577 National Eye Institute Duration: 9/1/15–8/31/18 $250,000

Research and Funding | UCLA STEIN EYE INSTITUTE 73 ADMINISTERED BY THE Fully-automated Lesion Characterization Clinical Research DOHENY EYE INSTITUTE in Ultrawide Field Retinal Images Eyenuk, Inc. Active Funding Sub-award on EY028081 Steven Barnes, PhD ADMINISTERED BY UCLA Functional Resilience of Retinal Duration: 6/1/18–5/31/19 Ganglion Cells During Mitochondrial $28,662 Dysfunction Anthony J. Aldave, MD Genetic Epidemiology of Age-Related Vision Restoration with a Collagen Glaucoma Research Foundation Macular Degeneration in the Older Crosslinked Boston Keratoprosthesis Shaffer Grant Order Amish Unit Duration: 2/26/19–2/15/20 University of Pennsylvania Department of Defense $50,000 Sub-award on NEI Grant EY023164 Sub-award from Massachusetts Eye and Duration: 2/1/13–1/31/19 Alex A. Huang, MD, PhD Ear Infirmary $60,784 Duration: 9/1/15–8/31/19 Structure and Function of Aqueous $81,011 Humor Outflow Alfredo A. Sadun, MD, PhD American Glaucoma Society and Post-mortem Analysis of LHON Patient Genetic Factors in Keratoconus Allergan Who Had Received AAV‑2 w/ ND4 Cedars-Sinai Medical Center Prime: Young Clinician Scientist Award Intravitreal Injection in One Eye National Eye Institute Duration: 3/17/15–7/30/18 GenSight Duration: 12/1/14–2/28/19 $20,000/initial year Duration: 7/20/18–10/31/19 $10,800 Glaukos Research (Outflowing Imaging) $12,739 Glaukos Corporation Ava K Bitner, OD Beacon Sensors and Telerehabilitation Duration: 10/17/15–11/30/19 Deming Sun, MD to Assess and Improve Use of Devices $10,000/two years Role of IL-17+ Autoreactive T Cells in Experimental Autoimmune Uveitis (EAU) for Visual Functioning (BeST-AID) SriniVas R. Sadda, MD National Eye Institute American Academy of Optometry Duration: 3/1/19-2/28/21 Advanced Image Analysis Tools for Duration: 9/1/09–7/31/20 $100,000 Diabetic Retinopathy Telemedicine $274,912 Applications Eyenuk, Inc. James C. Tan, MD, PhD Joseph Caprioli, MD The Efficacy and Safety of Bimatoprost Sub-award on NEI EY026864 Karl Kirchgessner Foundation Vision SR in Patients with Open-Angle Duration: 8/1/16–7/31/18 Research Grant Glaucoma or Ocular Hypertension $31,847 The Karl Kirchgessner Foundation Duration: 10/17/09–12/31/18 Allergan Pharmaceutical Corp. High Resolution Retinal Imaging by $50,000 Duration: 4/22/15–5/31/19 Fourier Ptychography $149,974 CalTech Fibrillin-1 and TGFB2 Abnormality Protocol INN-005 Sub-award on NEI Grant EY026228 Models PAOG InnFocus, Inc Duration: 4/1/16–3/31/19 Pathogenesis and Treatment Duration 2/4/16–11/13/19 $2,500 National Eye Institute Duration: 9/30/17–5/31/20 $435,556 Advanced Image Analysis Tools for $250,000 Diabetic Retinopathy Telemedicine Sophie X. Deng, MD, PhD Application Contractile Modulation of Distal Regeneration of a Normal Corneal Eyenuk, Inc. Aqueous Humor Drainage Surface by Limbal Stem Cell Therapy Sub-award on NEI Grant SB1EY027241 National Eye Institute California Institute for Regenerative Duration: 9/30/16–7/31/19 Duration: 6/1/18–5/31/20 Medicine (CIRM) $18,704 $125,000 Duration: 8/1/16–12/31/19 $922,786 Automated Image-based Biomarker Computation Tools for Diabetic Michael B. Gorin, MD, PhD Retinopathy Xolaris Eyenuk, Inc. NightstaRx Sub-award on NEI Grant TR000377 Duration: 9/28/17–8/31/19 Duration: 7/1/18–6/30/20 $135,770 $143,312 NIGHT Functionally Validated Structural NightstaRx Endpoints for Early AMD Duration: 6/18/15–3/26/20 University of Alabama at Birmingham $120,123 Sub-award on NEI Grant EY029595 Duration: 5/1/19–2/29/14 ALK-001 $91,655 Alkeus Pharmaceuticals Duration: 5/23/16–8/22/19 $46,070

74 UCLA STEIN EYE INSTITUTE | Research and Funding ARIS Rustum Karanjia, MD, PhD Peter A. Quiros, MD Greater Baltimore Medical Center Photopic Negative Response (PhNR) QRK207 Prime: National Eye Institute as an Objective Outcome Measure in Quark Pharmaceuticals, Inc. Duration: 5/1/19–6/1/24 Mitochondrial Disease Duration: 8/4/16–3/26/20 $80,000 United Mitochondrial Disease $121,227 Foundation STAR RGN-ON-002 Duration: 12/1/17–11/20/20 NightstaRx Regenera Pharma, Ltd. $50,000 Duration: 6/13/18–6/13/21 Duration: 1/2/19–1/2/22 $96,333 $232,016 Olivia L. Lee, MD OCU-300 Gary N. Holland, MD Daniel B. Rootman, MD Ocugen Inc. META-MUST RVT-1401-2001 Duration: 1/4/19–1/4/22 National Eye Institute Immunovant, Inc. $342,513 Sub-award from Johns Hopkins Duration: 5/14/19–5/13/23 University $292,758 Colin A. McCannel, MD Duration: 9/30/14–1/31/19 GR40548 $39,180 SriniVas R. Sadda, MD Genentech, Inc. BIRC-01 ZEDS Duration: 11/15/18–11/15/21 Boston Image Reading Center New York University $455,806 Duration: 2/1/18–2/28/21 Duration: 4/3/17–7/31/21 GR40549 $42,520 $345,545 Genentech, Inc. AREDS 2 10-Year Follow-up Duration: 11/26/18–1/26/22 Jean-Pierre Hubschman, MD Emmes Corporation $453,341 Extension Study of NT-501 Ciliary Duration: 11/1/17–12/31/18 Neurotrophic Factor (CNTF) Implant for GX28228 $20,790 Macular Telangiectasia (MacTel) Genentech, Inc. Lowy Medical Research Institute Duration: 9/22/15–6/12/19 Alfredo A. Sadun, MD, PhD Duration: 8/14/17–6/30/22 $381,650 EPI-743 $53,145 Edison Pharmaceuticals, Inc. Tara A. McCannel, MD, PhD Duration: 10/17/14–9/11/19 A Phase 3 Multicenter Randomized, AU-011-101 $55,860 Sham Controlled, Study to Determine Aura Biosciences Inc. the Safety and Efficacy of Renexus® in SPILH-2010 Duration: 9/28/17–9/28/19 Macular Telangiectasia Type 2 Stealth BioTherapeutics, Inc. $72,979 Lowy Medical Research Institute Duration: 2/12/16–7/24/19 Duration: 2/26/18–12/31/21 $415,909 Stacy L. Pineles, MD $290,150 Integrating Perceptual Learning Reality LHON Registry Approaches into Effective Therapies for Michael Ip, MD GenSight Biologics Low Vision Duration: 1/16/18–9/1/19 APL2-304 National Eye Institute $45,810 Apellis Pharmaceuticals Sub-award from University of California Duration: 5/9/19–5/8/23 Riverside GS-LHON-CLIN-06 $420,429 Duration: 9/1/13–7/31/19 GenSight Biologics Duration: 1/3/18–1/3/21 RHINE $166,874 $474,754 Genentech, Inc. Pediatric Eye Disease Investigator Duration: 3/5/19–3/5/23 Group (PEDIG) GS-LHON-CLIN-05 $470,911 JAEB Center for Health Research GenSight Biologics Duration: 8/23/18–8/23/21 AR-1105-CS201 Duration: 2/28/11–12/31/18 $214,091 Aerie Pharmaceuticals Inc. $112,143 Duration: 5/16/19–5/15/21 Luminopia VR Device Amblyopia Study $70,607 Luminopia, Inc. Duration: 11/28/18–11/28/21 $52,103

Research and Funding | UCLA STEIN EYE INSTITUTE 75 David Sarraf, MD Diabetic Retinopathy Clinical Research Network JAEB Center for Health Research Duration: 6/13/17–12/31/18 $215,081 The IAI-OCTA Study Regeneron Pharmaceuticals, Inc. Duration: 3/28/17–3/28/20 $211,609 Yosemite Genentech, Inc. Duration: 3/1/19–3/1/23 $470,514

Steve D. Schwartz, MD MA09-hRPE-001 Astellas Institute for Regenerative Medicine Duration: 4/5/11–5/7/20 $734,750 ACT MA09-hRPE 001(SMD) LTFU Astellas Institute for Regenerative Medicine Duration: 4/5/11–5/7/20 $661,734 7317-CL-0003 Astellas Institute for Regenerative Medicine Duration: 8/22/18–8/22/21 $680,530 OPH2005 Ophthotech Corporation Duration: 4/10/18–4/10/21 $305,751

Irena Tsui, MD Ophthalmic Manifestations of Congenital Zika Virus Infection National Eye Institute Duration: 3/1/17–2/28/19 $33,094

76 UCLA STEIN EYE INSTITUTE | Research and Funding Clinical Research Studies

Clinical Trials A Phase 3 Randomized, Safety and Determining the Safety and Efficacy of Renexus in Macular Telangiectasia RECRUITING Efficacy Study of Brimonidine Tartrate Nanoemulsion Eye Drops in Patients Type 2 with Ocular Graft-vs-Host Disease This study is assessing the safety of the A Double-Masked Clinical Study (oGVHD) NT-501 implant in patients with macu- Evaluating the Efficacy and Safety of To evaluate the safety, tolerability, and lar telangiectasia type 2. The implant, RPh201 Treatment in Participants with efficacy of Brimonidine Nanoemul- a small capsule of cells that is placed Previous NAION sion eye drops in patients with ocular inside the eye, allows a controlled, The primary study objective is to eval- graft vs host disease (oGVHD). Inves- sustained release of CNTF directly to uate the efficacy and safety of twice- tigators: Oliva L. Lee, MD, and John A. the retina. Investigators: Jean-Pierre weekly subcutaneous (SC) adminis- Irvine, MD ­Hubschman, MD, Steven D. Schwartz, tration of RPh201 over 26 weeks on MD, and Hamid Hosseini, MD visual function in participants with prior A Phase 3 Study to Compare the nonarteritic anterior ischemic optic Efficacy and Safety of Intravitreal Evaluating the Safety and Efficacy neuropathy (NAION). Investigators: APL-2 Therapy with Sham Injections in of Light-Activated AU-011 for the Peter A. Quiros, MD, and Alfredo A. Patients with Geographic Atrophy (GA) Treatment of Subjects with Small to Sadun, MD, PhD Secondary to Age-Related Macular Medium Primary Choroidal Melanoma Degeneration (AMD) Primary objectives are to evaluate A Multicenter, Open-Label, Safety, To evaluate the efficacy of APL-2 com- the safety of intravitreal administra- Tolerability, and Efficacy of AR-1105 in pared to sham injection in patients tion of one of three dose levels and Subjects with Macular Edema Due to with GA secondary to AMD assessed repeat dose regimens of light-activated Retinal Vein Occlusion (RVO) by change in the total area of GA AU-011 and one or two laser appli- To evaluate the safety and tolerability lesions from baseline as measured cations in the treatment of subjects of 2 formulations of AR-1105 in subjects by FAF. Investigators: Michael Ip, MD, with small to medium primary choroi- with macular edema due to branch ­Srinivas Sadda, MD, Gad Heilweil, MD, dal melanoma. Secondary objectives retinal vein occlusion (BRVO) or cen- ­Mohammed Khan, MD, and Phillip Le, include evaluating the immunogenic- tral retinal vein occlusion (CRVO). To MD, PhD ity and effectiveness of AU-011. Inves- evaluate the effect of AR-1105 on BCVA tigators: Tara A. McCannel, MD, PhD, by early treatment of diabetic retinop- A Phase 3 Study to Evaluate the Colin A. McCannel, MD, and Melissa W. athy study (ETDRS) methodology. To Efficacy and Safety of RO6867461 in Chun, OD evaluate the effect of AR-1105 on CRT/ Patients with Diabetic Macular Edema CFT and subretinal fluid by spectral (YOSEMITE and RHINE) Evaluation of a New Drug for domain ocular coherence tomography To evaluate the efficacy of IVT injec- Stargardt Disease (SD-OCT). Investigators: Michael Ip, tions of the 6-mg dose of RO6867461 The study purpose is to find out MD, Srinivas Sadda, MD, Gad Heilweil, on BCVA outcomes. Investigators: whether a new drug for Stargardt dis- MD, Mohammed Khan, MD, and Phillip David Sarraf, MD, Colin A. ­McCannel, ease is safe and effective. There are Le, MD, PhD MD, and Michael S. Ip, MD, Gad currently no proven treatments for ­Heilweil, MD, Mohammed Khan, MD Stargardt disease, a disease that leads A Phase 2b, Multicenter, Randomized, to blindness in almost all cases. Investi- Double-blind, Placebo-controlled Arm-Mounted Heidelberg OCT-A gators: Michael B. Gorin, MD, PhD, and Study of RVT-1401 for the Treatment for Noninvasive Vascular Zone Steven Nusinowitz, PhD of Patients with Active, Moderate to Imaging in Infants with Retinopathy of Severe Graves Ophthalmopathy Prematurity (ROP) Evaluation of Corneal Cross-Linking The purpose of the current study is This study evaluates OCT-A imag- Keratoprosthesis Carrier Tissue to assess the efficacy andsa ­ fety/​ ing data on preterm infants who are This clinical trial evaluates the safety to­ lerability of three dose regimens of screened and/or treated for ROP, espe- and efficacy of corneal collagen RVT-1401 in the treatment of active, cially evaluating the potentially benefi- cross-linking the keratoprosthesis moderate to severe GO patients. In cial effects of anti-VEGF treatment on carrier tissue in subjects who are can- addition, the study is designed to foveal development and visual out- didates for high-risk keratoprosthesis characterize RVT-1401 exposure to comes. Investigators: Alex Huang, MD, implantation because of a history of reduction in anti-TSHR IgG. Investiga- PhD, and Irena Tsui, MD corneal melts, sterile corneal ulcers, tor: ­Daniel B. ­Rootman, MD, MS, and or autoimmune diseases (eg, Stevens-​ ­Robert Alan Goldberg, MD Johnson syndrome, ocular cicatricial pemphigoid). Investigators: Anthony J. Aldave, MD, and Sophie X. Deng, MD, PhD

Research and Funding | UCLA STEIN EYE INSTITUTE 77 Macular Edema Ranibizumab v. A Phase 3 Study of the Efficacy, Safety, Evaluating the Efficacy and Safety of Intravitreal Anti-inflammatory Therapy and Pharmacokinetics of the Port an Investigational Eye Drop in Patients (MERIT) Trial Delivery System with Ranibizumab in with Open-Angle Glaucoma or Ocular The MERIT Trial was designed to deter- Patients with Neovascular Age-Related Hypertension mine which intravitreal therapy offers Macular Degeneration (ARCHWAY) This study evaluates the intraocu- the best balance of effectiveness and The primary objective of this study lar pressure-lowering efficacy and tolerability in treating persistent uve- is to evaluate the non-inferiority and safety of two dose strengths of an itic macular edema in eyes with con- equivalence in efficacy of ranibizumab investigational eye drop in patients trolled uveitis but persistent macular delivered via the PDS Q24W with the with open-angle glaucoma or ocular edema, specifically by comparing the 100mg/mL formulation compared with hypertension after initial and repeated relative efficacy and safety of intra- that of 10mg/mL Q4W intravitreal ran- administrations. Investigators: Joseph vitreal ranibizumab (Lucentis®) and ibizumab injections. Investigators: Colin Caprioli, MD, Anne L. Coleman, MD, intravitreal methotrexate to intravitreal A. McCannel, MD, Pradeep S. Prasad, PhD, JoAnn A. Giaconi, MD, Simon dexamethasone implant (Ozurdex®). MD, MBA, and David Sarraf, MD K. Law, MD, PharmD, and Kouros Investigators: Gary N. Holland, MD, ­Nouri‑Mahdavi, MD Colin A. ­McCannel, MD, and Pradeep A Protocol to Follow-up with Patients S. Prasad, MD on Emergency Administration of Evaluating the Efficacy of a Single EPI-743 with Leber Hereditary Optic Intravitreal Injection for Patients with Study of Luminopia One Digital Neuropathy Leber Hereditary Optic Neuropathy Therapeutic as Amblyopia Treatment EPI-743, a form of vitamin E that has This clinical trial is to assess the effec- The primary objective of this study been changed to a new compound tiveness of a gene therapy in improv- is to establish the safety and efficacy in the laboratory, is an experimental ing the visual outcome in patients with of the Luminopia One therapeutic for drug that may improve mitochondrial Leber Hereditary Optic Neuropathy the treatment of amblyopia. Investiga- function. Mitochondrial disease mani- (LHON) due to a mitochondrial muta- tors: Joseph L. Demer, MD, PhD, Simon festations appeared to improve when tion. Investigator: Alfredo A. Sadun, Fung, MD, and Stacy L. Pineles, MD the EPI-743 was given to cells from MD, PhD a patient with Leber hereditary optic Zoster Eye Disease Study (ZEDS) neuropathy that were grown in the lab- Evaluating the Use of an Implant for The purpose of this study is to find out oratory. Investigator: Alfredo A. Sadun, Patients with Macular Degeneration whether one year of a low dose of vala- MD, PhD This clinical trial determines the effi- cyclovir reduces complications of shin- cacy, safety, and pharmacokinetics gles affecting the eye. The study will A Trial of QPI-1007 Delivered by Single of ranibizumab delivered through involve two groups of participants who or Multi-Dose Intravitreal Injection(s) the implant using three ranibizumab-​ have eye problems due to shingles. to Subjects with Acute Nonarteritic ­formulation arms compared with the One group will receive daily valacyclo- Anterior Ischemic Optic Neuropathy control arm in patients with subfoveal vir medication and the other group will (NAION) neovascular (wet) age-related macular receive a placebo. Investigators: Gary This research study tests whether the degeneration. The study also evalu- N. Holland, MD, Anthony J. Aldave, MD, experimental drug QPI-1007 helps ates the safety of the ranibizumab port Sophie X. Deng, MD, PhD, and John A. prevent loss of visual acuity. QPI‑1007 delivery system combination product. Irvine, MD is being developed to treat vision Screening and randomization visits loss that can occur when there is not will be followed by a treatment period. enough blood flow to the nerve tissue Investigators: Colin A. McCannel, MD, Clinical Trials in the eye, such as after a stroke of the Tara A. McCannel, MD, PhD, Pradeep NOT RECRUITING optic nerve or from NAION. Investiga- S. Prasad, MD, MBA, Michael B. Gorin, tors: Peter A. Quiros, MD, Gad Heilweil, MD, PhD, and David Sarraf, MD MD, Michael S. Ip, MD, Mohammad A Multicenter, Open-Label Extension Khan, MD, Alfredo A. Sadun, MD, PhD Evaluation of a Drug for the Treatment Study to Evaluate the Long-Term of Leber Hereditary Optic Neuropathy Safety and Tolerability of the Port Corticosteroids for Uveitic Macular This study evaluates the safety, toler- Delivery System with Ranibizumab Edema ability, and efficacy of a topical oph- in Patients With Neovascular Age- This research study compares three thalmic solution in the treatment of Related Macular Degeneration treatments for macular edema in subjects with Leber Hereditary Optic (PORTAL) patients who have uveitis. Macular Neuropathy (LHON). The study drug Continuous delivery of ranibizumab edema is swelling of the retina at the has been shown to enhance or benefit from the implant, with a prolonged back of the eye, and it can cause vision mitochondria function in studies done fixed period between refills, is a novel loss. The standard treatment is to on cells grown in the laboratory. Inves- approach that may result in less-­ inject corticosteroid drugs next to the tigator: Alfredo A. Sadun, MD, PhD frequent need for retreatment than eye or directly into the eye. Investiga- monthly dosing and patient monitor- tors: Gary N. Holland, MD, and Colin A. ing. Investigators: Colin A. McCannel, McCannel, MD MD, Pradeep S. Prasad, MD, MBA, and David Sarraf, MD

78 UCLA STEIN EYE INSTITUTE | Research and Funding Extension Study of NT-501 Ciliary Safety and Effectiveness of the Biomechanical Analysis in Strabismus Neurotrophic Factor Implant for CustomFlex Artificial Iris Prosthesis for Surgery Macular Telangiectasia the Treatment of Iris Defects This study aims to develop new diag- The primary objective of this study is This study is being conducted to eval- nostic tests and computer models that to investigate long-term safety and uate the safety and effectiveness of will lead to improvements in strabismus efficacy of the NT-501 implant in par- an artificial iris prosthesis for the treat- surgery. Tests of binocular alignment ticipants previously enrolled in NTMT ment of full or partial aniridia resulting and eye movements, as well as mag- protocols. Investigators: Jean-Pierre from congenital aniridia, acquired iris netic resonance imaging of the extra- Hubschman, MD, Steven D. Schwartz, defects (including traumatic iris defects ocular muscles, are being performed MD, and Hamid Hosseini, MD and mydriasis), or conditions associ- in the Institute’s Clinical and Basic ated with full or partial aniridia, such Science Ocular Motility Laboratory IAI-OCTA Study as ocular or oculocutaneous albinism before and after strabismus surgery. To This study is utilizing a new, FDA and iridocorneal endothelial (ICE) syn- date, this research has fundamentally approved, non-standard of care drome, and iris coloboma. Investiga- contributed to the knowledge of the technology (optical coherence tors: Anthony J. Aldave, MD, and Kevin functional anatomy of the extraocular ­tomography-­angiography by Optovue) M. Miller, MD muscles and connective tissues, and to image and evaluate the treatment allowed discovery of causes of com- outcomes of using standard of care Safety and Efficacy of Zimura™ mon strabismus and development of intravitreal Aflibercept injections for (Complement C5 Inhibitor) Compared new types of surgeries. Investigator: their approved use in patients diag- to Sham in Subjects with Autosomal Joseph L. Demer, MD, PhD nosed with neovascular age-related Recessive Stargardt Disease macular degeneration who are naive to The objectives of this study are to Effect of External Eyelid Weighting previous Anti-VEGF therapies. Investi- evaluate the safety and efficacy of on Lid Position in Normal and Ptosis gator: David Sarraf, MD Zimura™ intravitreal injection compared Patients to sham in subjects with autosomal This investigation compares the abil- Repeated Doses of an Investigational recessive Stargardt disease 1. Investi- ity of normal and ptotic patients to Drug in Patients with Neovascular gators: ­Steven D. Schwartz, MD, Hamid maintain eyelid position by adapting Age-Related Macular Degeneration ­Hosseini, MD, Jean-Pierre Hubschman, to acute and dramatic changes in pro- This phase 2, year-long study requires MD, Pradeep S. Prasad, MD, Phd, and tracting forces by using eyelid weights. the recruitment of patients with wet Irena Tsui, MD This project will help elucidate the or neovascular age-related macular physiology of the eyelid position main- degeneration who are naive to anti- Study for Retinopathy of Prematurity tenance system, and provide insight VEGF treatment. Investigators: David This study is to determine if intravitreal into its ability to respond to changes Sarraf, MD, Michael B. Gorin, MD, PhD, ranibizumab is superior to laser abla- in disease. Investigator: Daniel B. and Colin A. McCannel, MD tion therapy in the treatment of retinop- ­Rootman, MD, MS athy of prematurity (ROP). The study Research with Retinal Cells Derived will assess the ability of these treat- Eye Health Imaging Study from Stem Cells for Stargardt Macular ments to lead to regression of active The purpose of this study is to expand Dystrophy ROP and prevent the development of the normative database for the This study evaluates the long-term ocular complications that are associ- ­Heidelberg Spectralis OCT by collect- safety and tolerability of MA09- ated with poor visual outcome. Investi- ing ophthalmic data from healthy eyes hRPE cellular therapy in subjects with gator: Irena Tsui, MD of people of Hispanic/Latino, Asian, advanced Stargardt macular dystro- and African American descent. Investi- phy from one to five years following gators: Kouros Nouri-Mahdavi, MD, and the surgical procedure to implant the Clinical Studies Joseph Caprioli, MD MA09-hRPE cells. Investigators: Steven RECRUITING D. Schwartz, MD, Hamid Hosseini, MD, Genetic and Anatomic Studies of Eye Jean-Pierre Hubschman, MD, Pradeep Movement Disorders Prasad, MD, and Irena Tsui, MD Analysis of the Corneal and Limbal This study is conducting magnetic Epithelial Changes in Limbal Stem resonance imaging of the extraocu- Cell Deficiency Using In Vivo Confocal lar muscles. This procedure clarifies Microscopy the phenotypes and mechanisms of Investigators are working to establish a congenital cranial dysinnervation syn- system for diagnosing limbal stem cell dromes whose hereditary properties deficiency at a cellular level by correlat- have been characterized using modern ing the information from impression molecular genetics. Patients with these cytology tests, confocal microscopy syndromes have severe forms of stra- pictures, and medical records. Inves- bismus. Investigator: Joseph L. Demer, tigators: Anthony J. Aldave, MD, and MD, PhD Sophie X. Deng, MD, PhD

Research and Funding | UCLA STEIN EYE INSTITUTE 79 The bench-to-bedside harmony of clinical studies being investigated in collaboration with basic science has created a spectrum of discovery in specialties across ophthalmology.

80 UCLA STEIN EYE INSTITUTE | Research and Funding Hyaluronic Acid Gels for Upper Lid Noninvasive Methods for Early Optical Coherence Tomography Retraction in Active State Thyroid Eye Detection of Alzheimer Disease Angiography Images of Pregnant Disease The purpose of this study is to obtain Women This study is to determine if hyaluronic electroretinography data and opti- This study aims to identify changes acid gel (HAG) can be used to cor- cal coherence tomography data from that occur in the retina as a result of rect upper eyelid retraction, improve patients with Alzheimer disease, with gestational associated diseases (eg, dry eye related symptoms, aesthetic the aim of permitting earlier interven- gestational diabetes, high blood pres- appearance, and quality of life in tion and improved disease monitoring. sure, increased myopia) and unknown active-stage thyroid eye disease (TED). Investigator: Alfredo A. Sadun MD, PhD changes that may affect the eyes The study also aims to determine the during gestation and in the two to three long-term outcome of TED and how Observational Study of Patients months following birth. Investigator: long the effects of HAG can last. Inves- Diagnosed with Idiopathic Bilateral Irena Tsui, MD tigator: Daniel B. Rootman, MD, MS Cataracts The purpose of this study is to under- Optical Coherence Tomography Modified Retinal Fundus Camera stand better how many people who Angiography of Foveal Avascular Zone This study evaluates a modified retinal have been diagnosed with early-onset in Premature Children fundus camera to see if significant dif- idiopathic bilateral cataracts may have This prospective study evaluates ferences can be found in patients with a rare but treatable disease called blood vessel development in chil- choroidal melanoma, age-related mac- cerebrotendinous xanthomatosis (CTX). dren and adults who are born early ular degeneration, or diabetic retinopa- Often one of the first signs of CTX is and compares them with children and thy. Investigator: Irena Tsui, MD cataract from an unknown cause at an adults who were not born early, by early age. Investigators: Federico G. getting optical coherence tomogra- Molecular and Cytogenetic Studies of Velez, MD, Stacy L. Pineles, MD, and phy (OCT), OCT-angiography, color Ocular Melanoma Joseph L. Demer, MD, PhD pictures, refraction, and axial length This research is to study ocular mel- on subjects with retinopathy of prema- anoma tumor tissue and to identify Ocular Biometric Measurements in turity and without retinopathy of pre- key molecular and genetic features Angle-Closure Glaucoma maturity. Investigators: Irena Tsui, MD, that could help predict those patients The purpose of this study is to deter- Stacy L. Pineles, MD, and Federico G. who may be at high risk for metasta- mine the potential contributing factors Velez, MD sis. Investigators: Lynn K. Gordon, MD, in angle-closure patients of different PhD, Tara A. McCannel, MD, PhD, and ethnicities and to determine predic- Optical Coherence Tomography in the Bradley R. Straatsma, MD, JD tive factors for this type of glaucoma. Newborn Eye Investigators: Joseph Caprioli, MD, This study is to better characterize the Natural History Study of Leber Anne L. Coleman, MD, PhD, Simon retina and optic nerve in newborns Hereditary Optic Neuropathy K. Law, MD, PharmD, and Kouros using spectral-domain optical coher- Leber hereditary optic neuropathy Nouri‑Mahdavi, MD ence tomography (SD-OCT). SD-OCT (LHON) is one of the diseases where has been used for many years to help the mitochondria of the retina cells are Oculoplastic Registry diagnose and treat adults with eye dis- not functioning correctly, which can Many orbital and ophthalmic plastic eases, but it has never been studied lead to loss of vision. This study is to surgical diseases are not well studied in newborns, where it could potentially obtain electroretinography (ERG) data in the medical literature. The purpose help in the diagnoses of glaucoma, and optical coherence tomography of this study is to contribute to a large optic nerve hypoplasia, foveal hypo- (OCT) data from patients who carry database of electronic measurements plasia, and colobomata, among many the Leber hereditary optic neuropathy from medical records that allow us to other disorders. Investigator: Sherwin gene. Investigator: Alfredo A. Sadun, study diseases in a way that was diffi- J. Isenberg, MD MD, PhD cult or impossible before. Investigator: Robert Alan Goldberg, MD, and Daniel Pediatric Cornea and Anterior Natural History Study of Macular B. Rootman, MD, MS Segment Diseases Registry Telangiectasia Pediatric cornea and anterior segment The primary study objective is to Optic Nerve in Amblyopia diseases are rarely encountered by develop a registry of participants with Amblyopia is a major cause of child- ophthalmologists. As such, details on MacTel Type 2 (as confirmed by the hood visual loss. This study uses high the causes, features, and optimal treat- Reading Center) who may agree to be resolution, surface-coil magnetic res- ment for these conditions are inade- contacted for inclusion in future clin- onance imaging to study optic nerve quately described. The information on ical trials. Investigators: Jean-Pierre size in amblyopia. It tests the theory this registry would allow us to study Hubschman, MD, Hamid Hosseini, MD, that the optic nerve is smaller than nor- these diseases. Investigator: Simon Allan E. Kreiger, MD, Tara A. ­McCannel, mal in amblyopia and that optic nerve Fung, MD MD, PhD, Pradeep S. Prasad, MD, size may be a limiting factor in resto- MBA, Irena Tsui, MD, and Steven D. ration of vision by amblyopia treat- Schwartz, MD ment. Investigator: Joseph L. Demer, MD, PhD

Research and Funding | UCLA STEIN EYE INSTITUTE 81 Pediatric Optic Neuritis Prospective Study of Macular Disease Using Analysis for Visual Function in Age- Outcomes Study (PON1) Spectral Domain Optical Coherence Related Macular Degeneration Optic neuritis is an acute inflammatory Tomography Angiography (SD-OCTA) The study establishes electrophysio- disease of the optic nerve. The pur- The RTVue XR 100 Avanti with SSADA logical benchmarks using the visual pose of this study is to collect infor- will be used to screen patients with evoked potential/pattern electro- mation about children who have optic macular disease as detected with clin- retinogram (VEP/PERG) protocols of neuritis and what happens to their eye- ical examination or ancillary testing, populations with glaucoma before sight. Investigator: Stacy L. Pineles, MD such as with standard OCT, color fun- treatment and after treatment. Inves- dus photography, fluorescein angiogra- tigators: SriniVas R. Sadda, MD, Gad PET/CT Imaging for Early Detection of phy, or fundus autofluorescence. Inves- Heilweil, MD, Brian A. Francis, MD, MS, Ocular Melanoma tigators: Michael B. Gorin, MD, PhD, Alex A. Huang, MD, PhD, and Vikas This research involves the use of com- Colin A. McCannel, MD, David Sarraf, Chopra, MD bined positron emission tomogra- MD, and Steven D. Schwartz, MD phy (PET)/computed tomography (CT) Analysis of Visual Function in scans in subjects with ocular mela- Understanding the Genetics of Glaucoma noma to ideally develop better ways Inherited Eye Disorders The purpose of this study is to estab- of monitoring for tumor spread and This study searches for the gene(s) lish electrophysiological benchmarks allow for early treatment if metastasis is responsible for inherited disorders using the Visual Evoked Potential/ found. Investigators: Tara A. McCannel, that are either specific to the eye or Pattern Electroretinogram protocols MD, PhD, and Bradley R. Straatsma, are part of the medical condition. The of populations with glaucoma before MD, JD study provides for the clinical charac- treatment and after treatment. Investi- terization of affected individuals and gators: Brian A. Francis, MD, MS, Alex Pro-Inflammatory Cytokines, Dry Eye, at-risk family members, in conjunction A. Huang, MD, PhD, Vikas Chopra, and Thyroid Eye Disease with molecular genetic testing, to iden- MD, SriniVas R. Sadda, MD, and Gad This study is to determine whether tify the causative genes and mutations. ­Heilweil, MD there are specific inflammatory proteins Investigators: Anthony J. Aldave, MD, in tears of patients with active-stage and Michael B. Gorin, MD, PhD Characteristics of the Brow–Eyelid thyroid eye disease (TED). If these Margin Relationship inflammatory proteins exist, the study The study purpose is to determine if aims to determine whether they can Clinical Studies changing the effect of gravity has an be used to predict dry eye symptom- NOT RECRUITING effect on eyelid position. Investigators: atology and TED activity. Investigators: Robert Alan Goldberg, MD, and Daniel Robert Alan Goldberg, MD, and Daniel B. Rootman, MD, MS B. Rootman, MD, MS A Prospective Observation Study of Adult Strabismus Clinical Characterization, Genetic Ptosis Surgery Outcomes Scale This study is to learn about treatments Testing, and Visual Function in This investigation is to define and val- for strabismus in adults. There are Patients with Stargardt Disease idate a universal measure for ptosis several different treatment options for Investigators are doing a compre- outcomes that can be used in defining strabismus: sometimes these condi- hensive analysis of visual function in both value and efficacy in ptosis sur- tions are treated with special glasses patients diagnosed with Stargardt dis- gery. Investigator: Daniel B. Rootman, that help to align the eyes (prism) or ease, an early onset form of macular MD, MS with exercises that help the eyes work degeneration caused by a number of together, and sometimes these con- mutations in the ABCR gene. They are Studies on Tissue in Autoimmune ditions are treated with surgery or performing molecular genetic test- Diseases Botox injection to straighten the eyes. ing to confirm the Stargardt diagnosis This study aims to determine the cause Investigators: Stacy L. Pineles, MD, and and better understand the diversity of of eye problems in Graves disease and ­Federico G. Velez, MD the condition. Investigators: Debora B. other autoimmune diseases. Examina- ­Farber, PhD, DPhhc, Michael B. Gorin, tion is being done of material removed An Extended-Use Program of MD, PhD, and Steven Nusinowitz, PhD from orbits during surgical therapy Elamipretide Topical Ophthalmic for Graves disease or other problems Solution for Patients with Leber’s Clinical Measurements of the Optic requiring surgery on the tissue sur- Hereditary Optic Neuropathy (LHON) Nerve in Glaucoma rounding the eyes, of thyroid tissue This extended-use program is to pro- The goal of this study is to develop removed during the course of surgical vide elamipretide to patients with novel structural measures of the optic therapy, or of blood drawn for labo- LHON previously enrolled in the SPILH- nerve and nerve fiber layer, which are ratory tests. Investigator: Robert Alan 201 clinical trial who are still benefit- sensitive and specific for early and Goldberg, MD ting from treatment per the discretion progressive glaucomatous optic nerve of the treating physician. Investigators: damage. Investigators: Joseph Caprioli, Alfredo A. Sadun, MD, and Rustum MD, Anne L. Coleman, MD, PhD, and Karanjia, MD Simon K. Law, MD, PharmD

82 UCLA STEIN EYE INSTITUTE | Research and Funding Effect of Yoga on Glaucoma Identifying Novel Genes for Fuchs Neuroendocrine Tumor Metastases in The purpose of this study is to exam- Corneal Endothelial Dystrophy the Eye and Orbit ine the practice of yoga and its ability Investigators are working to identify The purpose of this study is to under- to improve a patient’s vision by reliev- the gene(s) responsible for Fuchs cor- stand the diversity in presentation of ing stress and reducing eye pres- neal endothelial dystrophy, an inher- carcinoid tumors of the orbit, as well sure. Investigator: Anne L. Coleman, ited disorder that may result in irre- as to identify, stage, and grade related MD, PhD versible corneal swelling and loss of factors that may affect prognosis and vision. Investigators: Anthony J. Aldave, thus treatment decisions. Also con- Evaluating a Microshunt for the MD, Gary N. Holland, MD, and Bartly J. sidered will be if there are features of Treatment of Glaucoma Mondino, MD carcinoid tumor presentations in the This study is to assess the safety and orbit that can predict outcome and thus efficacy of a microshunt when used Keratoprosthesis Implantation in guide therapeutic decision-­making. to lower intraocular pressure (IOP) Patients with Corneal Opacification Investigator: Daniel B. Rootman, in subjects with primary open angle This study aims to determine the suc- MD, MS glaucoma whose IOP is not controlled cess rate of keratoprosthesis (artifi- when using maximum-tolerated glau- cial corneal) transplantation for visual Ocular Hypertension Treatment Study coma medications. Investigators: rehabilitation in patients with corneal Since topical hypotensive medications Joseph Caprioli, MD, Anne L. Co­ leman, opacification. Investigators: Anthony J. are safe and effective in delaying or MD, PhD, JoAnn A. Giaconi, MD, Simon Aldave, MD, and Gary N. Holland, MD preventing primary open angle glau- K. Law, MD, PharmD, and Brian A. coma, this study is examining whether ­Francis, MD, MS Long-term Follow-up of ND4 LHON other forms of treatment can be Subjects Treated with GS010 Ocular deferred with little or no penalty. Inves- Factors Related to the Severity of Gene Therapy in the RESCUE or tigator: Anne L. Coleman, MD, PhD Ocular Toxoplasmosis REVERSE Toxoplasmosis is a common para- To assess the long-term safety of Ocular Protrusion in Sitting and Supine sitic disease that can cause a vision-​ intravitreal GS010 administration up Positions ­threatening infection of the retina. to five years post treatment in sub- The aim of this study is to compare the Individuals with and without ocular jects who were treated in the RESCUE degree of ocular protrusion in normal toxoplasmosis are being evaluated or REVERSE studies. Investigators: individuals and patients with thyroid with a blood test to determine whether Alfredo A. Sadun, MD, and Rustum eye disease between sitting and lying (1) people can have a genetic predispo- Karanjia, MD (supine) positions. Investigators: ­Robert sition to severe disease when infected Alan Goldberg, MD, and Daniel B. with the parasite, or (2) there is a partic- Natural History of the Progression of ­Rootman, MD, MS ular strain of parasite that causes more Choroideremia severe disease than others. Investiga- This study characterizes the visual Ocular Surface Microbiome Study tors: Gary N. Holland, MD, and Ralph D. function and retinal structural changes This study aims to investigate and Levinson, MD associated with X-linked choroidere- understand the normal ecosystem of mia with the intention of determining microbes that live on the eye’s sur- Genetic Basis of Posterior the best means of measuring disease face and how their ecological system Polymorphous Corneal Dystrophy progression and the rate of natural changes and responds to routine eye This study seeks to identify the gene(s) progression for this condition. Investi- care and treatments. Investigators: responsible for posterior polymor- gators: Michael B. Gorin, MD, PhD, and Hugo Hsu, MD, Vikas Chopra, MD, and phous dystrophy, an inherited corneal Steven Nusinowitz, PhD Gad Heilweil, MD endothelial disorder that may result in irreversible corneal swelling and loss of Natural History of the Progression of Optic Nerve Appearance in Age- vision. Investigators: Anthony J. Aldave, X-Linked Retinitis Pigmentosa Related Macular Degeneration MD, and Gary N. Holland, MD This study is to characterize the visual In order to evaluate the relationship function and retinal structural changes between macular degeneration and Glaucoma Imaging Study associated with X-linked retinitis pig- optic nerve change, digital imaging This study is evaluating different imag- mentosa to determine the best means technology and photography are being ing techniques and their use in improv- of measuring disease progression used to assess the structural appear- ing open-angle glaucoma detection. and the rate of natural progression for ance of the optic nerve in patients Investigators: Kouros Nouri-Mahdavi, this condition. Investigator: Michael B. with age-related macular degener- MD, and Joseph Caprioli, MD Gorin, MD, PhD ation. Investigator: Simon K. Law, MD, PharmD

Research and Funding | UCLA STEIN EYE INSTITUTE 83 Pediatric Cataract Surgery Outcomes Sensory Processing and Learning Registry This study evaluates amblyopic The study aim is to collect core clinical patients, who are traditionally thought data on children and teens undergoing to be beyond the critical period for surgery for cataracts in order to con- treatment. These subjects will be duct analyses and generate hypoth- enrolled and randomized to one of the eses. Clinical outcomes data will be two amblyopia therapies using a per- collected from affected subjects after ceptual learning technique. Investiga- cataract surgery has been performed. tor: Stacy L. Pineles, MD Investigators: Stacy L. Pineles, MD, and Federico G. Velez, MD Sweep Visual Evoked Potential for Use in Amblyopia and Pediatric Optic Prevention of Visual Impairment in Nerve Disorders School-Age Children Using a new technique, investiga- To promote the use of eyeglasses in tors are measuring vision in preverbal schools, first- and second-grade stu- children to diagnose and follow optic dents with refractive errors receive two nerve diseases. Currently, treatment pairs of eyeglasses, with one pair stay- decisions are based on clinical exam- ing at home and the other in the class- inations that are insensitive and reveal room. School nurses collaborate with vision loss well after permanent dam- teachers in monitoring the use of eye- age has taken place. This technique glasses in the classroom, and parents allows more accurate examinations, receive eye care education. Investiga- which leads to provision of treatments tor: Anne L. Coleman, MD, PhD at the first signs of vision loss and thereby decreases the risk of perma- Research with Retinal Cells Derived nent damage. Investigators: Joseph L. from Stem Cells for Dry Age-Related Demer, MD, PhD, Sherwin J. Isenberg, Macular Degeneration (AMD) MD, Stacy L. Pineles, MD, and Federico This study evaluates the long-term G. Velez, MD safety and tolerability of MA09- hRPE cellular therapy in subjects with Temporal Fossa in Different Ethnicities advanced dry AMD from one to five The aim of this study is to investigate years following the surgical proce- differences in anatomy of tempo- dure to implant the MA09-hRPE cells. ral fossa between different ethnici- Investigators: Steven D. Schwartz, ties using three-dimensional CT scan MD, Hamid Hosseini, MD, Jean-Pierre images. Better knowledge of these ­Hubschman, MD, Pradeep S. Prasad, differences is important for cosmetic MD, MBA, and Irena Tsui, MD procedures to achieve better results and fewer complications. Investiga- Role of Pattern Electroretinogram tors: Robert Alan Goldberg, MD, and (PERG) in Glaucoma ­Catherine J. Hwang, MD This study is researching the elec- trophysiological test, pattern electro- Vision-Related Quality of Life and retinogram (PERG) to determine the Ocular Dominance role of PERG in estimating the risk of This study is designed to evaluate how future glaucoma progression and the quality of life is impacted by glaucoma reversibility of glaucomatous dam- in relation to eye dominance. It aims age after treatment. The latter could to determine whether quality of life is help clinicians better determine to affected more by glaucoma if it primar- what extent eye pressure needs to ily affects the dominant eye. Investi- be lowered to prevent disease pro- gators: Joseph Caprioli, MD, Anne L. gression. Investigators: Joseph Coleman, MD, PhD, JoAnn A. Giaconi, ­Caprioli, MD, Anne L. Coleman, MD, MD, and Simon K. Law, MD, PharmD PhD, JoAnn A. Giaconi, MD, Simon K. Law, MD, PharmD, and Kouros Nouri-Mahdavi, MD

84 UCLA STEIN EYE INSTITUTE | Research and Funding 2018–2019 Publications of the Full-Time Faculty

July 2018 Wang K, Ghasemi Falavarjani K, ­Nittala Mohammadi Sichani M, Kazemi R, MG, Sagong M, Wykoff CC, van­He mert Nour­ i-Mahdavi K, Gholipour F. Re- Akman A, Bayer A, Nouri-Mahdavi K. J, Ip M, Sadda SR. Ultra-Wide-Field evaluation of the efficacy of tranexamic Optical Coherence Tomography in ­Fluorescein Angiography-Guided Nor- acid in reducing blood loss in percuta- Glaucoma: A Practical Guide. Springer malization of Ischemic Index Calcula- neous nephrolithotomy: a randomized Verlag Berlin/Heidelberg. 2018. tion in Eyes With Retinal Vein Occlu- clinical trial. Minerva Urol Nefrol. 2019 sion. Invest Ophthalmol Vis Sci. 2018 Feb;71(1):55–62. Epub 2018 Jul 23. Amesbury EC, Miller KM. Toric Intra­ Jul 2;59(8):3278–3285. ocular Lens. In Narang P, Trattler W, ed. Ali MH, Berry S, Qureshi A, Rattanalert Optimizing Suboptimal Results Follow- Miller KM, Kuo A, Olson MD, ­Masket S. N, Demer JL. Decompensated Eso- ing Cataract Surgery: Refractive and Safety and efficacy of black iris dia- phoria as a Benign Cause of Acquired Non-Refractive Management. New phragm intraocular lens implantation in Esotropia. Am J Ophthalmol. 2018 York, NY: Thieme Publishers. 2018. eyes with large iris defects: Report 4. Oct;194:95–100. Epub 2018 Jul 24. J Cataract Refract Surg. 2018 Jun;​44(6):​ Friesen ET, Miller KM. Chapter 41, 686–700. Epub 2018 Jul 4. Pichi F, Sarraf D. Optically empty cho- Challenging Cataract Cases: Posterior roidal spaces in high hyperopia. Retin Polar. In Pranja NV, ed. Peyman’s Prin- Chen TC, Hoguet A, Junk AK, Cases Brief Rep. 2018 Jul 24. ciple & Practice of Ophthalmology, 2nd Nour­ i-Mahdavi K, Radhakrishnan S, Ed. New Delhi, India: Jaypee Brothers. Takusagawa HL, Chen PP. Spectral-​ Lo C, Ugradar S, Rootman D. Man- 2018. Domain OCT: Helping the Clinician agement of Graves myopathy: Orbital Diagnose Glaucoma: A Report by the imaging in thyroid-related orbitopathy. Nouri-Mahdavi K. Chapters, “Managing American Academy of Ophthalmology. J AAPOS. 2018 Aug;22(4):256.e1– Advanced Glaucomatous Damage Due Ophthalmology. 2018 Nov;125(11):1817– 256.e9. Epub 2018 Jul 25. Review. to Angle Closure Glaucoma” and “Man- 1827. Epub 2018 Jul 7. aging Pseudoexfoliation Glaucoma Borrelli E, Sarraf D, Freund KB, Sadda with Advanced Damage.” Glaucoma Glasgow BJ, Abduragimov AR. Ligand SR. OCT angiography and evalua- Imaging Atlas: A Diagnostic Imaging binding complexes in lipocalins: Under- tion of the choroid and choroidal vas- Guide for Glaucoma Assessment and estimation of the stoichiometry param- cular disorders. Prog Retin Eye Res. Management. Editor: Christian ­Mardin. eter (n). Biochim Biophys Acta Proteins 2018 Nov;67:30–55. Epub 2018 Jul 27. Heidelberg Engineering Academy, Proteom. 2018 Oct;1866(10):1001–1007. Review. ­Heidelberg, Germany. 2018. Epub 2018 Jul 7. Hanna RM, Lopez EA, Hasnain H, Shieh E, Miller KM. Chapter 44, Chal- Gu L, Bok D, Yu F, Caprioli J, Piri N. Selamet U, Wilson J, Youssef PN, lenging Cataract Cases: Weak Zonules, Downregulation of splicing regulator Akladeous N, Bunnapradist S, Gorin Pseudoexfoliation, and Traumatic Cata- RBFOX1 compromises visual depth MB. Three patients with injection of racts. In Pranja NV, ed. Peyman’s Prin- perception. PLoS One. 2018 Jul 12;​13(7):​ intravitreal vascular endothelial growth ciple & Practice of Ophthalmology, 2nd e0200417. factor inhibitors and subsequent exac- Ed. New Delhi, India: Jaypee Brothers. erbation of chronic proteinuria and 2018. Al-Hashimi S, Donaldson K, Davidson hypertension. Clin Kidney J. 2019 R, Dhaliwal D, Jackson M, Kieval JZ, Feb;12(1):92–100. Epub 2018 Jul 27. Ghassabi Z, Shanbehzadeh J, Nouri- Patterson L, Stonecipher K, Hamilton Mahdavi K. A Unified Optic Nerve DR; ASCRS Refractive Cataract Surgery Garrity ST, Govetto A, Hubschman JP. Head and Optic Cup Segmentation Subcommittee. Medical and surgical Branch Retinal Artery Wall Rupture and Using Unsupervised Neural Net- management of the small pupil during Subsequent Occlusion During Pars works for Glaucoma Screening. Conf cataract surgery. J Cataract Refract Plana Vitrectomy with Membrane Peel. Proc IEEE Eng Med Biol Soc. 2018 Jul;​ Surg. 2018 Aug;44(8):1032–1041. Epub Retin Cases Brief Rep. 2018 Jul 30. 2018:5942–5945. 2018 Jul 19. Review. Stadtmueller BM, Bridges MD, Dam KM, Nittala MG, Velaga SB, Hu Z, Sadda SR. Clark RA, Demer JL. Magnetic Reso- Lerch MT, Huey-Tubman KE, Hubbell Relationship Between Dry Retinal nance Imaging of the Globe-Tendon WL, Bjorkman PJ. DEER Spectroscopy Volume and Visual Acuity in Diabetic Interface for Extraocular Muscles: Is Measurements Reveal Multiple Con- Macular Edema. Ophthalmic Surg There an “Arc of Contact”? Am J Oph- formations of HIV-1 SOSIP Envelopes Lasers Imaging Retina. 2018 Jul 1;49(7):​ thalmol. 2018 Oct;194:170–181. Epub that Show Similarities with Envelopes 510–515. 2018 Jul 19. on Native Virions. Immunity. 2018 Aug 21;49(2):235–246.e4. Epub 2018 Jul 31. Nassisi M, Fan W, Shi Y, Lei J, Borrelli E, Ip M, Sadda SR. Quantity of Intraret- Subramanian PS, Arnold AC. Con- inal Hyperreflective Foci in Patients troversies in Neuro-Ophthalmology: With Intermediate Age-Related Macular Where the Evidence Leads Us. Asia Degeneration Correlates With 1-Year Pac J Ophthalmol (Phila). 2018 Jul–Aug;​ Progression. Invest Ophthalmol Vis Sci. 7(4):​215–217. 2018 Jul 2;59(8):3431–3439.

Research and Funding | UCLA STEIN EYE INSTITUTE 85 August 2018 Borrelli E, Shi Y, Uji A, Balasubramanian Bittner AK, Yoshinaga P, Bowers A, S, Nassisi M, Sarraf D, Sadda SR. Topo- Shepherd JD, Succar T, Ross NC. Hutchinson AK, Kraker RT, Pineles SL, graphic Analysis of the Choriocapillaris ­Feasibility of Telerehabilitation for Low VanderVeen DK, Wilson LB, Galvin JA, in Intermediate Age-related Macular Vision: Satisfaction Ratings by Provid- Lambert SR. The Use of β-Blockers for Degeneration. Am J Ophthalmol. 2018 ers and Patients. Optom Vis Sci. 2018 the Treatment of Periocular Heman- Dec;196:34–43. Epub 2018 Aug 16. Sep;95(9):865–872. giomas in Infants: A Report by the American Academy of Ophthalmology. Nassisi M, Shi Y, Fan W, Borrelli E, Velez FG, Davila JP, Diaz A, Corradetti ­Ophthalmology. 2019 Jan;126(1):​146– Uji A, Ip MS, Sadda SR. Choriocapillaris G, Sarraf D, Pineles SL. Association of 155. Epub 2018 Aug 1. impairment around the atrophic lesions Change in Iris Vessel Density in Optical in patients with geographic atrophy: Coherence Tomography Angiography Borrelli E, Lonngi M, Balasubrama- a swept-source optical coherence With Anterior Segment Ischemia After nian S, Tepelus TC, Baghdasaryan E, tomography angiography study. Br J Strabismus Surgery. JAMA Ophthalmol. Pineles SL, Velez FG, Sarraf D, Sadda Ophthalmol. 2019 Jul;103(7):911–917. 2018 Sep 1;136(9):1041–1045. SR, Tsui I. Increased choriocapillaris Epub 2018 Aug 21. vessel density in amblyopic children: Founti P, Coleman AL, Wilson MR, Yu F, a case-control study. J AAPOS. 2018 Kovach JL, Isildak H, Sarraf D. Crystal- Anastasopoulos E, Harris A, Pappas T, Oct;22(5):366–370. Epub 2018 Aug 2. line retinopathy: Unifying pathogenic Koskosas A, Kilintzis V, Salonikiou A, pathways of disease. Surv Ophthalmol. Raptou A, Topouzis F. Overdiagnosis Bakhoum MF, Freund KB, Dolz-Marco 2019 Jan–Feb;64(1):1–29. Epub 2018 of open-angle glaucoma in the general R, Leong BCS, Baumal CR, Duker JS, Aug 23. Review. population: the Thessaloniki Eye Study. Sarraf D. Paracentral Acute Middle Acta Ophthalmol. 2018 Nov;96(7):​ Maculopathy and the Ischemic Cas- Yang MC, Al-Hashimi S, Rootman DB. e859–e864. Epub 2018 Sep 4. cade Associated With Retinal Vascular Salzmann’s nodular degeneration of Occlusion. Am J Ophthalmol. 2018 Nov;​ cornea associated with thyroid eye dis- Yao Y, Qu J, Dong C, Li X, Liang J, Yin 195:​143–153. Epub 2018 Aug 3. ease. Orbit. 2019 Aug;38(4):​325–327. H, Huang L, Li Y, Liu P, Pan C, Ding X, Epub 2018 Aug 27. Song D, Sadda SR, Zhao M. The impact Kogachi K, Ter-Zakarian A, Asanad S, of extent of internal limiting mem- Sadun A, Karanjia R. Toxic medications Chen CW, Lee YH, Gerber MJ, Cheng brane peeling on anatomical outcomes in Leber’s hereditary optic neuropathy. H, Yang YC, Govetto A, Francone AA, of macular hole surgery: results of a Mitochondrion. 2019 May;46:270–277. Soatto S, Grundfest WS, Hubschman 54-week randomized clinical trial. Acta Epub 2018 Aug 4. Review. JP, Tsao TC. Intraocular robotic inter- Ophthalmol. 2019 May;97(3):303–312. ventional surgical system (IRISS): Epub 2018 Sep 5. Balasubramanian S, Beckmann J, Semi-automated OCT-guided cataract Mehta H, Sadda SR, Chanwimol K, removal. Int J Med Robot. 2018 Dec;​ Kintzer AF, Green EM, Dominik PK, Nassisi M, Tsui I, Marlow N, Jain S. 14(6):e1949. Epub 2018 Aug 28. Bridges M, Armache JP, Deneka D, Kim Relationship between Retinal Thick- SS, Hubbell W, Kossiakoff AA, Cheng ness Profiles and Visual Outcomes in Prasad P. Injury to the Eye. JAMA. 2018 Y, Stroud RM. Structural basis for acti- Young Adults Born Extremely Preterm: Aug 28;320(8):846. vation of voltage sensor domains in The EPICure@19 Study. Ophthalmol- an ion channel TPC1. Proc Natl Acad ogy. 2019 Jan;126(1):107–112. Epub 2018 Balasubramanian S, Borrelli E, Lonngi Sci USA. 2018 Sep 25;​115(39):​E9095– Aug 6. M, Velez F, Sarraf D, Sadda SR, Tsui I. E9104. Epub 2018 Sep 6. Visual function and optical coherence Le Q, Cordova D, Xu J, Deng SX. In tomography angiography features in Heiden D, Tun N, Smithuis FN, Keenan Vivo Evaluation of the Limbus Using children born preterm. Retina. 2018 JD, Oldenburg CE, Holland GN, Drew Anterior Segment Optical Coherence Aug 30. WL. Active cytomegalovirus retinitis Tomography. Transl Vis Sci Technol. after the start of antiretroviral therapy. 2018 Aug 7;7(4):12. September 2018 (Fall) Br J Ophthalmol. 2019 Feb;103(2):157– 160. Epub 2018 Sep 8. Terry MA, Aldave AJ, Szczotka-Flynn Bittner AK, Haythornthwaite JA, Patel LB, Liang W, Ayala AR, Maguire MG, C, Smith MT. Subjective and Objec- Ausayakhun S, Yen M, Jirawison C, Croasdale C, Daoud YJ, Dunn SP, tive Measures of Daytime Activity and Ausayakhun S, Khunsongkiet P, Hoover CK, Macsai MS, Mauger TF, Sleep Disturbance in Retinitis Pigmen- ­Leenasirimakul P, Kamphaengkham S, Pramanik S, Rosenwasser GOD, tosa. Optom Vis Sci. 2018 Sep;​95(9):​ Snyder BM, Heiden D, Holland GN, Rose-Nussbaumer J, Stulting RD, Sugar 837–843. Margolis TP, Keenan JD. Visual acuity A, Tu EY, Verdier DD, Yoo SH, Lass JH; outcomes in cytomegalovirus retinitis: Cornea Preservation Time Study Bittner AK, Jacobson AJ, Khan R. Fea- early versus late diagnosis. Br J Oph- Group. Donor, Recipient, and Operative sibility of Using Bluetooth Low Energy thalmol. 2018 Dec;102(12):1607–1610. Factors Associated with Graft Success Beacon Sensors to Detect Magnifier Epub 2018 Sep 11. in the Cornea Preservation Time Study. Usage by Low Vision Patients. Optom Ophthalmology. 2018 Nov;125(11):1700– Vis Sci. 2018 Sep;95(9):844–851. 1709. Epub 2018 Aug 9.

86 UCLA STEIN EYE INSTITUTE | Research and Funding Gu X, Bridges MD, Yan Y, de Waal PW, Baghdasaryan E, Tepelus TC, ­Marion Nguyen AH, Fatehi N, Romero P, Zhou XE, Suino-Powell KM, Xu HE, KM, Huang J, Huang P, Sadda SR, ­Miraftabi A, Kim E, Morales E, Giaconi J, Hubbell WL, Melcher K. Conformational Lee OL. Analysis of ocular inflamma- Coleman AL, Law SK, Caprioli J, Nouri-​ heterogeneity of the allosteric drug tion in anterior chamber-­involving uve- Mahdavi K. Observational Outcomes and metabolite (ADaM) site in AMP- itis using swept-source anterior seg- of Initial Trabeculectomy With Mitomy- activated protein kinase (AMPK). ment OCT. Int Ophthalmol. 2019 Aug;​ cin C in Patients of African Descent vs J Biol Chem. 2018 Nov 2;293(44):​ 39(8):1793–1801. Epub 2018 Sep 20. Patients of European Descent: Five- 16994–17007. Epub 2018 Sep 11. Year Results. JAMA Ophthalmol. 2018 Pineles SL, Velez FG. Anterior supe- Oct 1;136(10):1106–1113. Tsui I, Moreira MEL, Rossetto JD, rior oblique tuck: an alternate treat- ­Vasconcelos Z, Gaw SL, Neves LM, ment for excyclotorsion. J AAPOS. Arnold AC. Urgent Evaluation of the Zin OA, Haefeli L, Silveira Filho JCB, 2018 Oct;22(5):393–393.e1. Epub 2018 Patient With Acute Central Retinal Gomes SC Jr, Adachi K, Pone MVDS, Sep 20. Artery Occlusion. Am J Ophthalmol. Pone SM, Pereira JP Jr, ­Belfort R, 2018 Dec;196:xvi–xvii. Epub 2018 ­Arumugaswami V, Brasil P, ­Nielsen-​ Pichi F, Fragiotta S, Freund KB, Au A, Oct 2. Saines K, Zin AA. Eye Findings in Lembo A, Nucci P, Sebastiani S, Infants With Suspected or Confirmed ­Gutierrez Hernandez JC, Interlandi E, Figueroa MS, Govetto A, Steel DH, Antenatal Zika Virus Exposure. Pediat- Pellegrini F, Dolz-Marco R, Gallego-​ Sebag J, Virgili G, Hubschman JP. Pars rics. 2018 Oct;142(4). Epub 2018 Sep 13. Pinazo R, Orellana-Rios J, Adatia FA, Plana Vitrectomy for the Treatment of Munro M, Abboud EB, Ghazi N, Cunha Tractional and Degenerative Lamellar Felszeghy S, Viiri J, Paterno JJ, Souza E, Amer R, Neri P, Sarraf D. Cilio­ Macular Holes: Functional and Anatom- ­Hyttinen JMT, Koskela A, Chen M, retinal artery hypoperfusion and its ical Results. Retina. 2018 Oct 3. ­Leinonen H, Tanila H, Kivinen N, association with paracentral acute ­Koistinen A, Toropainen E, ­Amadio M, middle maculopathy. Br J Ophthalmol. Chew EY, Clemons TE, Jaffe GJ, Smedowski A, Reinisalo M, ­Winiarczyk 2019 Aug;103(8):1137–1145. Epub 2018 ­Johnson CA, Farsiu S, Lad EM, M, Mackiewicz J, ­Mutikainen M, Sep 26. Guymer R, Rosenfeld P, Hu­ bschman JP, ­Ruotsalainen AK, Kettunen M, ­Jokivarsi ­Constable I, Wiley H, Singerman LJ, K, Sinha D, Kinnunen K, ­Petrovski G, Nittala MG, Hogg RE, Luo Y, Velaga Gillies M, Comer G, Blodi B, Eliott D, Blasiak J, Bjørkøy G, Koskelainen A, SB, Silva R, Alves D, Staurenghi G, Yan J, Bird A, Friedlander M; Macu- Skottman H, Urtti A, Salminen A, ­Chakravarthy U, Sadda SR. Changes lar Telangiectasia Type 2-Phase 2 Kann­ an R, Ferrington DA, Xu H, in Retinal Layer Thickness in the Con- CNTF Research Group. Effect of Ciliary Levonen AL, Tavi P, Kauppinen A, tralateral Eye of Patients with Unilat- ­Neurotrophic Factor on Retinal Neuro­ ­Kaarniranta K. Loss of NRF-2 and eral Neovascular Age-Related Macular degeneration in Patients with Macular PGC-1α genes leads to retinal pig- Degeneration. Ophthalmol Retina. 2019 Telangiectasia Type 2: A Randomized ment epithelium damage resembling Feb;3(2):112–121. Epub 2018 Sep 27. Clinical Trial. Ophthalmology. 2019 Apr;​ dry age-related macular degeneration. 126(4):540–549. Epub 2018 Oct 4. Redox Biol. 2019 Jan;20:1–12. Epub Wang MY, Asanad S, Asanad K, 2018 Sep 14. ­Karanjia R, Sadun AA. Value of medi- Hariri AH, Ip MS, Girach A, Lam BL, cal history in ophthalmology: A study Fischer MD, Sankila EM, Pennesi ME, Mehravaran S, Quan A, Hendler K, of diagnostic accuracy. J Curr Ophthal- Holz FG, Maclaren RE, Birch DG, Yu F, Coleman AL. Implementing mol. 2018 Sep 27;30(4):359–364. Hoyng CB, MacDonald IM, Black GC, enhanced education to improve the Tsang SH, Bressler NM, Stepien KE, Larsen M, Gorin MB, Meunier I, UCLA Preschool Vision Program. October 2018 J AAPOS. 2018 Dec;22(6):441–444. ­Webster AR, Sadda S; For Natural His- Epub 2018 Sep 15. Au A, Hou K, Baumal CR, Sarraf D. tory of the Progression of Choroider- Radial Hemorrhage in Henle Layer emia (NIGHT) Study Group. Macular Demer JL, Clark RA. Functional anat- in Macular Telangiectasia Type 2. spatial distribution of preserved auto- omy of human extraocular muscles JAMA Ophthalmol. 2018 Oct 1;136(10):​ fluorescence in patients with choroi- during fusional divergence. J Neuro- 1182–1185. deremia. Br J Ophthalmol. 2019 Jul;​ physiol. 2018 Nov 1;120(5):2571–2582. 103(7):933–937. Epub 2018 Oct 8. Epub 2018 Sep 19. Dean M, Kirschen D, Hubschman JP, Straatsma BR, Sarraf D, Francone A. Hsu HY, Ernst B, Schmidt EJ, Parihar R, Li X, Liang D, Shao H, Born WK, Kaplan Bilateral Acquired Progressive Retinal Horwood C, Edelstein SL. Laboratory HJ, Sun D. Adenosine receptor activa- Nerve Fiber Layer Myelination. Oph- Results, Epidemiologic Features, and tion in the Th17 autoimmune responses thalmic Surg Lasers Imaging Retina. Outcome Analyses of Microbial Kera- of experimental autoimmune uveitis. 2018 Oct 1;49(10):e147–e150. titis: A 15-Year Review From St. Louis. Cell Immunol. 2019 May;339:24–28. Am J Ophthalmol. 2019 Feb;198:54–62. Epub 2018 Sep 19. Lim MC, Holland GN. Clinical Con- Epub 2018 Oct 9. cepts, Coding, and How It Relates to Big Data. JAMA Ophthalmol. 2018 Quinn N, Csincsik L, Flynn E, Curcio Oct 1;136(10):1191–1192. CA, Kiss S, Sadda SR, Hogg R, Peto T, Lengyel I. The clinical relevance of visualising the peripheral retina. Prog Retin Eye Res. 2019 Jan;68:83–109. Epub 2018 Oct 10. Review.

Research and Funding | UCLA STEIN EYE INSTITUTE 87 Zloto O, Lubetsky A, Ben-­Bassat Phelps DL, Watterberg KL, Nolen TL, Ghassabi Z, Nguyen AH, Amini N, ­Mizrachi I, Kesler A, Quiros PA, Cole CA, Cotten CM, Oh W, ­Poindexter Henry S, Caprioli J, Nouri-Mahdavi K. Huna-Baron R. Prognostic value of BB, Zaterka-Baxter KM, Das A, Lacy The Fovea-BMO Axis Angle and Mac- JAK2V617F mutation in pse­ udotumor CB, Scorsone AM, Walsh MC, Bell EF, ular Thickness Vertical Asymmetry cerebri associated with cerebral Kennedy KA, Schibler K, Sokol GM, Across The Temporal Raphe. J Glau- venous sinus thrombosis. Acta Neurol Laughon MM, Lakshminrusimha S, coma. 2018 Nov;27(11):993–998. Scand. 2019 Feb;139(2):166–171. Epub Truog WE, Garg M, Carlo WA, ­Laptook 2018 Oct 11. AR, Van Meurs KP, Carlton DP, Graf A, Freund KB, Sarraf D, Leong BCS, DeMauro SB, Brion LP, Shankaran S, ­Garrity ST, Vupparaboina KK, Arya M, Rebhun CB, Alibhai AY, Orge FH, Olson RJ, Mintz-Hittner H, ­Dansingani KK. Association of Opti- Chen X, Moreira-Neto C, Baumal CR, Yang MB, Haider KM, Wallace DK, cal Coherence Tomography Angiog- Reichel E, Witkin AJ, Duker JS, Sadda Chung M, Hug D, Tsui I, Cogen MS, raphy of Collaterals in Retinal Vein SR, Waheed NK. Parafoveal Retinal Donahue JP, Gaynon M, ­Hutchinson Occlusion With Major Venous Outflow Vessel Density Assessment by Opti- AK, Bremer DL, Quinn G, He YG, Through the Deep Vascular Complex. cal Coherence Tomography Angiog- Lucas WR Jr, Winter TW, Kicklighter JAMA Ophthalmol. 2018 Nov 1;​136(11):​ raphy in Healthy Eyes. Ophthalmic SD, Kumar K, Chess PR, Colaizy TT, 1262–1270. Surg Lasers Imaging ­Retina. 2018 Oct Hibbs AM, Ambalavanan N, Harmon 15;49(10):S5–S17. HM, McGowan EC, Higgins RD; Eunice Gupta RR, Iaboni DSM, Seamone ME, Kennedy Shriver National Institute of Sarraf D. Inner, outer, and full-thickness Hazim RA, Volland S, Yen A, Burgess Child Health and Human Development retinal folds after rhegmatogenous ret- BL, Williams DS. Rapid differentiation Neonatal Research Network. Effects inal detachment repair: A review. Surv of the human RPE cell line, ARPE-19, of Myo-inositol on Type 1 Retinopathy Ophthalmol. 2019 Mar–Apr;64(2):135– induced by nicotinamide. Exp Eye Res. of Prematurity Among Preterm Infants 161. Epub 2018 Nov 1. Review. 2019 Feb;179:18–24. Epub 2018 Oct 15. <28 Weeks’ Gestational Age: A Ran- domized Clinical Trial. JAMA. 2018 Oct Tseng VL, Chlebowski RT, Yu F, Cauley Angeles-Han ST, Yeh S, Patel P, Duong 23;320(16):1649–1658. JA, Li W, Thomas F, Virnig BA, Coleman D, Jenkins K, Rouster-Stevens KA, AL. Notice of Retraction and Replace- Altaye M, Fall N, Thornton S, Prahalad Sebastiani S, Pellegrini M, ­Giannaccare ment. Tseng et al. Association of cat- S, Holland GN. Discovery of tear bio- G, Sarraf D. Paracentral acute mid- aract surgery with mortality in older markers in children with chronic non-​ dle maculopathy associated with women: findings from the Women’s infectious anterior uveitis: a pilot study. ­phosphodiesterase-5 inhibitor therapy. Health Initiative. JAMA Ophthalmol. J Ophthalmic Inflamm Infect. 2018 Retin Cases Brief Rep. 2018 Oct 25. 2018;136(1):3–10. JAMA Ophthalmol. Oct 16;8(1):17. 2018 Nov 1;136(11):1313–1314. Velez FG, Pineles SL. Adjustable Pos- Rabiolo A, Gelormini F, Sacconi R, terior Fixation Suture Technique in Velez FG, Pineles SL. Management of Cicinelli MV, Triolo G, Bettin P, Nouri-​ Adjustable Superior Rectus Transpo- surgical overcorrections following sur- Mahdavi K, Bandello F, Querques G. sition. J Binocul Vis Ocul Motil. 2018 gery for Duane syndrome with esotro- Comparison of methods to quantify Oct–Dec;68(4):154–155. Epub 2018 pia in primary position. J AAPOS. 2019 macular and peripapillary vessel den- Oct 26. Feb;23(1):2–4. Epub 2018 Nov 2. sity in optical coherence tomography angiography. PLoS One. 2018 Oct 18;​ Fantini M, Asanad S, Karanjia R, 13(10):e0205773. November 2018 Sadun A. Hormone replacement ther- Alizadeh R, Vickers L, Hirunpatravong apy in Leber’s hereditary optic neu- Ugradar S, Goldberg R, Rootman D. P, Romero P, Lin MC, Sharifipour F, ropathy: Accelerated visual recovery Anatomic variation of the entrance of Caprioli J. A Phenotype of Primary in vivo. J Curr Ophthalmol. 2018 Nov 3;​ the optic canal into the orbit. Orbit. Open-angle Glaucoma With Systemic 31(1):102–105. 2019 Aug;38(4):305–307. Epub 2018 Vasospasm. J Glaucoma. 2018 Nov;​ Oct 18. 27(11):987–992. Lenis TL, Hu J, Ng SY, Jiang Z, ­Sarfare S, Lloyd MB, Esposito NJ, Samuel W, Zin AA, Tsui I, Rossetto JD, Gaw SL, Driver TH, Aravena C, Duong HNV, Jaworski C, Bok D, Finnemann SC, Neves LM, Zin OA, Haefeli L, Barros Christenbury JG, Yu F, Basak SK, Radeke MJ, Redmond TM, Travis GH, Silveira Filho JC, Adachi K, Vinicius Aldave AJ. Outcomes of the Boston Radu RA. Expression of ABCA4 in the da Silva Pone M, Pone SM, Molleri N, Type I Keratoprosthesis as the Pri- retinal pigment epithelium and its impli- Pereira JP Jr, Belfort R, ­Arumugaswami mary Penetrating Corneal Procedure. cations for Stargardt macular degen- V, Vasconcelos Z, Brasil P, Nielsen-​ ­Cornea. 2018 Nov;37(11):1400–1407. eration. Proc Natl Acad Sci USA. 2018 Saines K, Lopes Moreira ME. Visual Nov 20;115(47):E11120–E11127. Epub function in infants with antenatal Zika El Hamouly A, Fung S, Sami H, ­Jiandani 2018 Nov 5. virus exposure. J AAPOS. 2018 Dec;​ D, Williams S, Mireskandari K, Ali A. 22(6):452–456.e1. Epub 2018 Oct 22. Endothelial cell loss in obstetric ­forceps-​related corneal injury: a lon- gitudinal specular microscopic study. Cornea. 2018 Nov;37(11):1421–1424.

88 UCLA STEIN EYE INSTITUTE | Research and Funding Retinal pigment epithelium cell culture derived from human stem cells. Photo: Roni Hazim, PhD, postdoctoral fellow in the laboratory of David Williams, PhD.

Research and Funding | UCLA STEIN EYE INSTITUTE 89 Tan ACS, Pilgrim MG, Fearn S, VanderVeen DK, Kraker RT, Pineles SL, Leng Y, Tam EK, Falavarjani KG, Tsui I. ­Bertazzo S, Tsolaki E, Morrell AP, Li M, Hutchinson AK, Wilson LB, Galvin JA, Effect of Age and Myopia on Retinal Messinger JD, Dolz-Marco R, Lei J, Lambert SR. Use of Orthokeratology Microvasculature. Ophthalmic Surg ­Nittala MG, Sadda SR, Lengyel I, for the Prevention of Myopic Progres- Lasers Imaging Retina. 2018 Dec 1;​ ­Freund KB, Curcio CA. Calcified nod- sion in Children: A Report by the Amer- 49(12):925–931. ules in retinal drusen are associated ican Academy of Ophthalmology. Oph- with disease progression in age-­ thalmology. 2019 Apr;126(4):623–636. Pichi F, Abboud EB, Sarraf D. Is the related macular degeneration. Sci Epub 2018 Nov 23. Association of Retinal Venous Malfor- Transl Med. 2018 Nov 7;10(466). mations With Venous Malformations Baulier E, Garcia Diaz A, Corneo B, of the Brain Clinically Meaningful?-​ Yeganeh A, Sinha KR, Fell D, Rootman Far­ ber DB. Generation of a human Reply. JAMA Ophthalmol. 2018 Dec 1;​ DB. The effect of eyebrow stenting on Ocular Albinism type 1 iPSC line, 136(12):1425. the measurement of levator excursion SEIi001-A, with a mutation in GPR143. in normal and ptotic eyelids. Orbit. 2019 Stem Cell Res. 2018 Dec;33:274–277. Lee OL, Tepelus TC, Huang J, Irvine Oct;38(5):353–356. Epub 2018 Nov 9. Epub 2018 Nov 28. AG, Irvine C, Chiu GB, Sadda SR. Eval- uation of the corneal epithelium in non- Asanad S, Meer E, Fantini M, Borrelli E, Carta A, Mora P, Aldigeri R, Gozzi F, Sjögren’s and Sjögren’s dry eyes: an in Sadun AA. Leber’s hereditary optic Favilla S, Tedesco S, Calzetti G, Farci R, vivo confocal microscopy study using neuropathy: Shifting our attention to Barboni P, Bianchi-Marzoli S, ­Fossarello HRT III RCM. BMC Ophthalmol. 2018 the macula. Am J Ophthalmol Case M, Gandolfi S,Sadun AA. Optical Dec 4;18(1):309. Rep. 2018 Nov 13;13:13–15. coherence tomography is a useful tool in the differentiation between true Pereira JP Jr, Nielsen-Saines K, Kassem A, Karanjia R, McClelland C, edema and pseudoedema of the optic ­Sperling J, Maykin MM, Damasceno L, Sadun A, Lee MS. Unilateral cone-rod disc. PLoS One. 2018 Nov 29;​13(11):​ Cardozo RF, Valle HA, Dutra BRT, dysfunction and retinal thinning in a e0208145. Gama HD, Adachi K, Zin AA, Tsui I, child carrying the 14484 mutation of Vasconcelos Z, Brasil P, Moreira ME, Leber hereditary optic neuropathy. Caprioli J, Mohamed L, Morales Gaw SL. Association of Prenatal Ultra- J AAPOS. 2019 Apr;23(2):104–106. E, Rabiolo A, Sears N, Pradtana H, sonographic Findings With Adverse Epub 2018 Nov 14. ­Alizadeh R, Yu F, Afifi AA,Coleman AL, Neonatal Outcomes Among Pregnant Nouri-Mahdavi K. A Method to Mea- Women With Zika Virus Infection in Nassisi M, Baghdasaryan E, Tepelus T, sure the Rate of Glaucomatous Visual Brazil. JAMA Netw Open. 2018 Dec 7;​ Asanad S, Borrelli E, Sadda SR. Topo- Field Change. Transl Vis Sci Technol. 1(8):e186529. graphic distribution of choriocapillaris 2018 Nov 30;7(6):14. flow deficits in healthy eyes. PLoS One. Au A, Sarraf D. Vascular anatomy 2018 Nov 15;13(11):e0207638. and its relationship to pathology in December 2018 (Winter) retinoschisis. Eye (Lond). 2019 May;​ Dastiridou AI, Katsanos A, Denis P, Falavarjani KG, Shenazandi H, Naseri D, 33(5):693–694. Epub 2018 Dec 12. Francis BA, Mikropoulos DG, Teus MA, Anvari P, Sedaghat A, Hashemi M, Konstas AG. Cyclodestructive Proce- Sadun AA. Correlation of optic disc Lopes Moreira ME, Nielsen-Saines K, dures in Glaucoma: A Review of Cur- morphometry and optic disc microvas- Brasil P, Kerin T, Damasceno L, Pone M, rent and Emerging Options. Adv Ther. culature assessed with optical coher- Carvalho LMA, Pone SM, Vasconcelos 2018 Dec;35(12):2103–2127. Epub 2018 ence tomography angiography. Can J Z, Ribeiro IP, Zin AA, Tsui I, Adachi K, Nov 17. Review. Ophthalmol. 2018 Dec;53(6):595–599. Gaw SL, Halai UA, Salles TS, da Cunha DC, Bonaldo MC, Raja Gabaglia C, Gangalum RK, Kim D, Kashyap RK, Graubart EB, Waxman EL, Forster SH, Guida L, Malacarne J, Costa RP, Gomes Mangul S, Zhou X, Elashoff D,Bhat SP . Giaconi JA, Rosenberg JB, Sankar PS, SC Jr, Reis AB, Soares FVM, Hasue RH, Spatial Analysis of Single Fiber Goyal A, Mirza RG. Ophthalmology Aizawa CYP, Genovesi FF, Aibe M, Cells of the Developing Ocular Lens Objectives for Medical Students: Revis- ­Einspieler C, Marschik PB, Pereira JP Reveals Regulated Heterogeneity of iting What Every Graduating Medical Jr, Portari EA, Janzen C, Cherry JD. Gene Expression. iScience. 2018 Dec Student Should Know. Ophthalmology. Neuro­development in Infants Exposed 21;10:66–79. Epub 2018 Nov 17. 2018 Dec;125(12):1842–1843. to Zika Virus In Utero. N Engl J Med. 2018 Dec 13;379(24):2377–2379. Hoguet A, Chen PP, Junk AK, Thorne A, Dyk DW, Fanney D, Mruthyunjaya P, Nouri-Mahdavi K, Miller KM. Phacoemulsifier occlu- Bai X, Yang XJ, Cheng Y, Chen L. Radhakrishnan S, Takusagawa HL, sion break surge volume reduction. Establishment of an induced pluri­ Chen TC. The Effect of Anti-Vascular J ­Cataract Refract Surg. 2018 Dec;​ potent stem cell line (FDEENTi001-A) Endothelial Growth Factor Agents on 44(12):​1491–1496. from a patient with pathological myo- Intraocular Pressure and Glaucoma: A pia. Stem Cell Res. 2019 Jan;34:101369. Report by the American Academy of Ip MS. Treatment of Central Retinal Epub 2018 Dec 14. Ophthalmology. Ophthalmology. 2019 Vein Occlusion-A New Look at a Blast Apr;126(4):611–622. Epub 2018 Nov 22. From the Past. JAMA Ophthalmol. 2018 Dec 1;136(12):1397–1398.

90 UCLA STEIN EYE INSTITUTE | Research and Funding Kashani AH, Green KM, Kwon J, Chu Z, Aravena C, Bozkurt K, Chuephanich P, Velaga SB, Nittala MG, Jenkins D, Zhang Q, Wang RK, Garrity S, Sa­ rraf D, Supiyaphun C, Yu F, Deng SX. Classi- Melendez J, Ho A, Strauss RW, Scholl Rebhun CB, Waheed NK, Schaal KB, fication of Limbal Stem Cell Deficiency HP, Sadda SR. Impact of segmenta- Munk MR, Gattoussi S, Freund KB, Using Clinical and Confocal Grading. tion density on spectral domain optical Zheng F, Liu G, Rosenfeld PJ. Sus- Cornea. 2019 Jan;38(1):1–7. coherence tomography assessment in pended Scattering Particles in Motion: Stargardt disease. Graefes Arch Clin A Novel Feature of OCT Angiography Baghdasaryan E, Tepelus TC, Marion Exp Ophthalmol. 2019 Mar;257(3):549– in Exudative Maculopathies. Ophthal- KM, Bagherinia H, Sadda SR, Hsu HY. 556. Epub 2019 Jan 6. mol Retina. 2018 Jul;2(7):694–702. Evaluation of Corneal Epithelial Thick- Epub 2017 Dec 15. ness Imaged by High Definition Opti- Haritoglou C, Tadayoni R, Hubschman cal Coherence Tomography in Healthy JP. Lamellar macular hole surgery - cur- Huang AS, Penteado RC, Papoyan Eyes. Cornea. 2019 Jan;38(1):62–66. rent concepts, future prospects. Clin V, Voskanyan L, Weinreb RN. Aque- Ophthalmol. 2019 Jan 8;13:143–146. ous angiographic outflow improve- Chu J, Thi T, Chopra V. Anterior-­ ment after trabecular microbypass in Segment OCT to Visualize and Treat Le Q, Deng SX. The application of glaucoma patients. Ophthalmology Capsular Bag Distension Syndrome. human amniotic membrane in the Glaucoma 1, 11–21. Published online: Ophthalmology. 2019 Jan;126(1):124. surgical management of limbal stem December 17, 2018. cell deficiency. Ocul Surf. 2019 Apr;​ Fung S, Elbaz U, Mireskandari K, Ali A. 17(2):221–229. Epub 2019 Jan 8. McClements ME, Barnard AR, Singh Graft versus host disease: a pediatric Review. MS, Charbel Issa P, Jiang Z, Radu RA, perspective. Exp Rev Ophthalmol 2019;​ MacLaren RE. An AAV Dual Vector 14(2):89–99. Pereira JP Jr, Maykin MM, ­Vasconcelos Strategy Ameliorates the Stargardt Z, Avvad-Portari E, Zin AA, Tsui I, Phenotype in Adult Abca4-/- Mice. Hu M, Wang H, Huang AS, Li L, Shi Y, ­Brasil P, Nielsen-Saines K, Moreira ME, Hum Gene Ther. 2019 May;30(5):590– Xu Y, Wang N. Microcatheter-assisted Gaw SL. The Role of Amniocentesis in 600. Epub 2018 Dec 24. Trabeculotomy for Primary ­Congenital the Diagnosis of Congenital Zika Syn- Glaucoma After Failed Glaucoma Sur- drome. Clin Infect Dis. 2019 Jan 8. Hariri AH, Gui W, Datoo O’Keefe geries. J Glaucoma. 2019 Jan;28(1):1–6. GA, Ip MS, Sadda SR, Gorin MB. Wingler LM, Elgeti M, Hilger D, Ultra-Widefield Fundus Autofluores- González S, Oh D, Baclagon ER, Zheng ­Latorraca NR, Lerch MT, Staus DP, Dror cence Imaging of Patients with Retinitis JJ, Deng SX. Wnt Signaling Is Required RO, Kobilka BK, Hubbell WL, Lefkowitz Pigmentosa: A Standardized Grading for the Maintenance of Human Limbal RJ. Angiotensin Analogs with Divergent System in Different Genotypes. Oph- Stem/Progenitor Cells In Vitro. Invest Bias Stabilize Distinct Receptor Confor- thalmol Retina. 2018 Jul;2(7):735–745. Ophthalmol Vis Sci. 2019 Jan 2;​60(1):​ mations. Cell. 2019 Jan 24;176(3):468– Epub 2017 Dec 27. 107–112. 478.e11. Epub 2019 Jan 10.

Sadda SR, Borrelli E, Fan W, Ebraheem Sun MM, Chan AM, Law SM, Duarte S, Jung JJ, Chen MH, Shi Y, Nassisi M, A, Marion KM, Kwon S. Impact of mydri- Diaz-Aguilar D, Wadehra M, Gordon LK. Marion K, Sadda SR, Hoang QV. Cor- asis in fluorescence lifetime imaging Epithelial Membrane Protein-2 (EMP2) relation of en face optical coherence ophthalmoscopy. PLoS One. 2018 Dec Antibody Blockade Reduces Corneal tomography angiography averaging 28;13(12):e0209194. Neovascularization in an In Vivo Model. versus single-image quantitative mea- Invest Ophthalmol Vis Sci. 2019 Jan 2;​ surements with retinal vein occlusion 60(1):245–254. visual outcomes. Retina. 2019 Jan 22. January 2019 Dunn JP, Miller KM. Chapter 6. Nd:YAG Navajas EV, Schuck N, Govetto A, Akil Csaky KG, Patel PJ, Sepah YJ, Laser Capsulotomy and Anterior Lens H, Docherty G, Heisler M, Sarunic MV, Birch DG, Do DV, Ip MS, Guymer RH, Surface Polishing. In Hausheer JR. Sarraf D. En face optical coherence Luu CD, Gune S, Lin H, Ferrara D. Basic Techniques of Ophthalmic Sur- tomography and optical coherence Microperimetry for geographic atro- gery, 3rd Ed. San Francisco: American tomography angiography of inner reti- phy secondary to age-related macular Academy of Ophthalmology. 2019. nal dimples after internal limiting mem- degeneration. Surv Ophthalmol. 2019 brane peeling for full-thickness macular May-Jun;64(3):353–364. Epub 2019 Koreishi A, Galor A, Yoo SH, Miller holes. Retina. 2019 Jan 3. Jan 28. KM. Chapter 2. Phacoemulsification. In Hausheer JR. Basic Techniques of Yang YM, Chow PE, McCannel TA, Kim JH, Rabiolo A, Morales E, Fatehi N, Ophthalmic Surgery, 3rd Ed. San Fran- Lamb JM. A comparison of the shield- Lee WS, Yu F, Afifi AA,Nouri- ­Mahdavi cisco: American Academy of Ophthal- ing effectiveness of silicone oil vit- K, Caprioli J. Cataract Surgery and mology. 2019. reous substitutes when used with Rate of Visual Field Progression in ­Palladium-103 and Iodine-125 eye Primary Open-Angle Glaucoma. Am J Miller KM. Chapter 18, Sulcus IOL Fix- plaques. Med Phys. 2019 Feb;​46(2):​ Ophthalmol. 2019 May;201:19–30. Epub ation – My Technique. In Chang DF. 1006–1011. Epub 2019 Jan 4. 2019 Jan 28. Advanced IOL Fixation Techniques: Strategies for compromised or miss- ing capsular support. Thorofare, NJ: SLACK Inc. 2019.

Research and Funding | UCLA STEIN EYE INSTITUTE 91 Huang J, Gu S, Chen M, Zhang SJ, Yang H, Luo H, Gardiner SK, Hardin C, Nassisi M, Baghdasaryan E, Borrelli E, Jiang Z, Chen X, Jiang C, Liu G, Radu Sharpe GP, Caprioli J, Demirel S, Girkin Ip M, Sadda SR. Choriocapillaris flow RA, Sun X, Vollrath D, Du J, Yan B, CA, Liebmann JM, Mardin CY, Quigley impairment surrounding geographic Zhao C. Abnormal mTORC1 signaling HA, Scheuerle AF, Fortune B, Chauhan atrophy correlates with disease pro- leads to retinal pigment epithelium BC, Burgoyne CF. Factors Influencing gression. PLoS One. 2019 Feb 22;​ degeneration. Theranostics. 2019 Jan Optical Coherence Tomography Peri- 14(2):e0212563. 30;9(4):1170–1180. papillary Choroidal Thickness: A Multi­ center Study. Invest Ophthalmol Vis Glasgow BJ. Ellipsometry of human Sinha KR, Al Shaker S, Yeganeh A, Sci. 2019 Feb 1;60(2):795–806. tears. Ocul Surf. 2019 Apr;17(2):341– Moreno T, Rootman DB. The Relation- 346. Epub 2019 Feb 25. ship Between Eyebrow and Eyelid Asanad S, Tian JJ, Frousiakis S, Jiang Position in Patients With Ptosis, Der- JP, Kogachi K, Felix CM, Fatemeh D, Garrity ST, Jung JY, Zambrowski O, matochalasis and Controls. Ophthal- Irvine AG, Ter-Zakarian A, Falavarjani Pichi F, Su D, Arya M, Waheed NK, mic Plast Reconstr Surg. 2019 Jan/ KG, ­Barboni P, Karanjia R, Sadun AA. Duker JS, Chetrit Y, Miserocchi E, Feb;35(1):85–90. Optical Coherence Tomography of ­Giuffrè C, Kaden TR, Querques G, the Retinal Ganglion Cell Complex in Souied EH, Freund KB, Sarraf D. Early ­Leber’s Hereditary Optic Neuropathy hydroxychloroquine retinopathy: opti- February 2019 and Dominant Optic Atrophy. Curr Eye cal coherence tomography abnormal- Asanad S, Meer E, Tian JJ, Fantini M, Res. 2019 Jun;44(6):638–644. Epub ities preceding Humphrey visual field Nassisi M, Sadun AA. Leber’s heredi- 2019 Feb 4. defects. Br J Ophthalmol. 2019 Feb 28. tary optic neuropathy: Severe vascular Li Y, Wei Q, Le A, Gawargious BA, pathology in a severe primary muta- March 2019 (Spring) tion. Intractable Rare Dis Res. 2019 Demer JL. Rectus Extraocular Mus- Feb;8(1):52–55. cle Paths and Staphylomata in High Deng SX, Borderie V, Chan CC, Myopia. Am J Ophthalmol. 2019 Dana R, Figueiredo FC, Gomes JAP, Asanad S, Wu J, Nassisi M, Ross-­ May;201:37–45. Epub 2019 Feb 4. Pellegrini G, Shimmura S, Kruse FE; Cisneros FN, Sadun AA. Optical coher- and The International Limbal Stem ence tomography-angiography in El-Abedin Rajab GZ, Demer JL. Long- Cell Deficiency Working Group. Global Wolfram syndrome: a mitochondrial eti- term results of surgical excision of Consensus on Definition, Classification, ology in disease pathophysiology. Can conjunctival retention cyst using try- Diagnosis, and Staging of Limbal Stem J Ophthalmol. 2019 Feb;54(1):e27–e30. pan blue with methylcellulose. Am J Cell Deficiency. Cornea. 2019 Mar;​ Ophthalmol Case Rep. 2019 Feb 6;​ 38(3):364–375. Demer JL. Childhood Self-­perceptions 14:28–31. in Children With Amblyopia: Is the Ip MS, Oden NL, Scott IU, Problem the Disease or the Treatment? Lin SR, Aldave AJ, Chodosh J. Recur- ­VanVeldhuisen PC, Blodi BA, ­Ghuman JAMA Ophthalmol. 2019 Feb 1;​137(2):​ rent corneal erosion syndrome. Br J T, Baker CW; SCORE2 Investiga- 174–175. Ophthalmol. 2019 Sep;103(9):1204– tor Group. Month 12 Outcomes After 1208. Epub 2019 Feb 13. Review. Treatment Change at Month 6 Among Tsui I, Pineles SL. What Coats Disease Poor Responders to Aflibercept or and Age-Related Macular Degenera- Catapano J, Fung S, Halliday W, ­Bevacizumab in Eyes With Macular tion Have in Common. JAMA Ophthal- Jobst C, Cheyne D, Ho ES, Zuker RM, Edema Secondary to Central or Hemi- mol. 2019 Feb 1;137(2):184. Borschel GH, Ali A. Treatment of neu- retinal Vein Occlusion: A Secondary rotrophic keratopathy with minimally Analysis of the SCORE2 Study. JAMA Wang M, Lau LI, Sreekumar PG, Spee invasive corneal neurotization: long- Ophthalmol. 2019 Mar 1;137(3):281–287. C, Hinton DR, Sadda SR, Kannan R. term clinical outcomes and evidence of Characterization and Regulation of Car- corneal reinnervation. Br J Ophthalmol. Sun MM, Levinson RD, Filipowicz A, rier Proteins of Mitochondrial Glutathi- 2019 Feb 15. Anesi S, Kaplan HJ, Wang W, Goldstein one Uptake in Human Retinal Pigment DA, Gangaputra S, Swan RT, Sen HN, ­Epithelium Cells. Invest Ophthalmol Vis Zhang X, Parrish RK 2nd, Greenfield Gordon LK. Uveitis in Patients Treated Sci. 2019 Feb 1;60(2):500–516. DS, Francis BA, Varma R, Schuman JS, with CTLA-4 and PD-1 Checkpoint Tan O, Huang D; Advanced Imaging Blockade Inhibition. Ocul Immunol for Glaucoma Study Group. Predic- Inflamm. 2019 Mar 1:1–11. tive Factors for the Rate of Visual Field Progression in the Advanced Imaging for Glaucoma Study. Am J Ophthal- mol. 2019 Jun;202:62–71. Epub 2019 Feb 20.

Clark RA, Choy AE, Demer JL. Lateral rectus sag and recurrent esotropia in children. J AAPOS. 2019 Apr;23(2):81. e1–81.e5. Epub 2019 Feb 21.

92 UCLA STEIN EYE INSTITUTE | Research and Funding Aldave AJ, Terry MA, Szczotka-Flynn April 2019 Fang M, Fan W, Shi Y, Ip MS, Wykoff LB, Liang W, Ayala AR, Maguire MG, CC, Wang K, Falavarjani KG, Brown DM, Chopra V, Lee CC. Progressive OCT O’Brien RC, Benetz BA, Bokosky JE, van Hemert J, Sadda SR. Classifica- Retinal Nerve Fiber Layer Loss in Dunn SP, Gillette TE, Hammersmith tion of Regions of Nonperfusion on Myopia. Ophthalmology. 2019 Apr;​ KM, Hardten DR, Jeng BH, Jones MF, Ultra-widefield Fluorescein Angiogra- 126(4):529–530. ­Lindstrom RL, Maverick KJ, Nirankari phy in Patients with Diabetic Macular VS, Oliva MS, Raber IM, Rapuano CJ, Edema. Am J Ophthalmol. 2019 Apr 5. Liu X, Law SK. Autologous Partial-­ Rosenwasser GOD, Ross KW, ­Seedor thickness Scleral Flap and Donor Cor- JW, Shamie N, Stoeger CG, Tauber S, Huang J, Tepelus TC, Baghdasaryan E, neal Graft in Management of Tube Van Meter WS, Verdier DD, Lass JH; Huang P, Shi Y, Hsu HY, Sadda SR, Erosion of Glaucoma Drainage Device. Cornea Preservation Time Study Lee OL. Correlation between Guttata J Glaucoma. 2019 Apr;28(4):347–351. Group. Effect of Graft Attachment Severity and Thickness of Descemet’s Membrane and the Central Cornea. Status and Intraocular Pressure on Sadun AA, Asanad S. The Eye in Curr Eye Res. 2019 Aug;44(8):849– Descemet Stripping Automated Endo- ­Alzheimer’s Disease. Ophthalmology. 855. Epub 2019 Apr 5. thelial Keratoplasty Outcomes in the 2019 Apr;126(4):511–512. Cornea Preservation Time Study. Am J Chen MF, Meer E, Velez FG, Jones M, Ophthalmol. 2019 Jul;203:78–88. Epub Wang YE, Tepelus TC, Gui W, Irvine Mathern GW, Pineles SL. Etiology and 2019 Mar 6. JA, Lee OL, Hsu HY. Reduction of Age Modifies Subjective Visual Func- Acanthamoeba Cyst Density Asso- tion After Cerebral Hemispherectomy. Rostami B, Nguyen-Cuu J, Brown G, ciated With Treatment Detected by J Child Neurol. 2019 Jul;34(8):446–451. Brown M, Sadun AA, Sebag J. Cost-­ In Vivo Confocal Microscopy in Acan- Epub 2019 Apr 7. Effectiveness of Limited Vitrectomy for thamoeba Keratitis. Cornea. 2019 Apr;​ Vision-Degrading Myodesopsia. Am J 38(4):463–468. Ophthalmol. 2019 Aug;204:1–6. Epub Zhang C, Tannous E, Zheng JJ. Oxi- dative stress upregulates Wnt signal- 2019 Mar 6. Asanad S, Ross-Cisneros FN, Nassisi ing in human retinal microvascular M, Barron E, Karanjia R, Sadun AA. The endothelial cells through activation of Chen MF, Kim CH, Coleman AL. Retina in Alzheimer’s Disease: Histo- disheveled. J Cell Biochem. 2019 Aug;​ Cyclodestructive procedures for refrac- morphometric Analysis of an Ophthal- 120(8):14044–14054. Epub 2019 Apr 8. tory glaucoma. Cochrane Database mologic Biomarker. Invest Ophthalmol Syst Rev. 2019 Mar 10;3:CD012223. Vis Sci. 2019 Apr 1;60(5):1491–1500. Ervin AM, Strauss RW, Ahmed MI, Birch D, Cheetham J, Ferris FL Borrelli E, Sadda SR, Uji A, Querques Corbelli E, Parravano M, Sacconi 3rd, Ip MS, Jaffe GJ, Maguire MG, G. Pearls and Pitfalls of Optical Coher- R, Sa­ rraf D, Yu SY, Kim K, Capuano ­Schönbach EM, Sadda SR, West SK, ence Tomography Angiography Imag- V, Miere A, Souied E, Varano M, Scholl HPN; ProgStar Study Group. A ing: A Review. Ophthalmol Ther. 2019 ­Boninfante A, Chae B, Carnevali A, Workshop on Measuring the Progres- Jun;8(2):215–226. Epub 2019 Mar 13. Querques L, Bandello F, Querques G. sion of Atrophy Secondary to Stargardt Review. Prevalence and Phenotypes of Age-​ Disease in the ProgStar Studies: Find- Related Macular Degeneration in Eyes Putthirangsiwong B, Katsev B, ings and Lessons Learned. Transl Vis With High Myopia. Invest Ophthalmol ­Steinsapir KD, Goldberg RA, Rootman Sci Technol. 2019 Apr 12;8(2):16. Vis Sci. 2019 Apr 1;60(5):1394–1402. DB. Surgical Predictors of Reduced Goldberg RA. Commentary on: Reha- Marginal Reflex Distance After Upper Grove JCR, Hirano AA, de Los Sa­ ntos bilitation of the Dysmorphic Lower Eye- Blepharoplasty. Ophthalmic Plast J, McHugh CF, Purohit S, Field GD, lid From Hyaluronic Acid Filler: What to Reconstr Surg. 2019 Mar 21. Brecha NC, Barnes S. Novel hybrid Do After a Good Periocular Treatment action of GABA mediates inhibitory Sadda SR, Borrelli E, Fan W, Ebraheem Goes Bad. Aesthet Surg J. 2019 Apr 17. feedback in the mammalian retina. A, Marion KM, Harrington M, Kwon S. PLoS Biol. 2019 Apr 1;17(4):e3000200. A pilot study of fluorescence lifetime Pineles SL, Chang MY, Holmes JM, Kekunnaya R, Özkan SB, Velez FG. imaging ophthalmoscopy in preclin- Rangchian A, Francone A, Farajzadeh Innovative techniques for the treatment ical Alzheimer’s disease. Eye (Lond). M, Hosseini H, Connelly K, Hubschman of adult strabismus. J AAPOS. 2019 2019 Aug;33(8):1271–1279. Epub 2019 JP, Kavehpour P. Effects of Collagenase Jun;23(3):132–139. Epub 2019 Apr 17. Mar 28. type II on Vitreous Humor, an in-situ Rheological Study. J Biomech Eng. Lin SR, Prapaipanich P, Yu F, Law SK, 2019 Apr 3. Caprioli J, Aldave AJ, Deng SX. Com- parison of endothelial keratoplasty Takusagawa HL, Hoguet A, Junk AK, techniques in patients with prior glau- Nouri-Mahdavi K, Radhakrishnan S, coma surgery - a case-matched study. Chen TC. Swept-Source OCT for Eval- Am J Ophthalmol. 2019 Mar 29. uating the Lamina Cribrosa: A Report by the American Academy of Oph- thalmology. Ophthalmology. 2019 Sep;126(9):1315–1323. Epub 2019 Apr 4.

Research and Funding | UCLA STEIN EYE INSTITUTE 93 Angeles-Han ST, Ringold S, ­Beukelman May 2019 Morshedian A, Kaylor JJ, Ng SY, T, Lovell D, Cuello CA, Becker ML, Tsan A, Frederiksen R, Xu T, Yuan L, Lin M, Alizadeh R, Law SK. Outcomes Colbert RA, Feldman BM, Ho­ lland Sampath AP, Radu RA, Fain GL, Travis of Combined Ahmed Glaucoma Valve GN, Ferguson PJ, Gewanter H, GH. Light-Driven Regeneration of Cone and Trabeculectomy Revision With ­Guzman J, Horonjeff J, Nigrovic PA, Visual Pigments through a Mechanism Adjunctive Antimetabolite. J Glaucoma. Ombrello MJ, Passo MH, Stoll ML, Involving RGR Opsin in Müller Glial 2019 May;28(5):404–410. ­Rabinovich CE, Sen HN, Schneider R, Cells. Neuron. 2019 Jun 19;102(6):1172– Halyabar O, Hays K, Shah AA, ­Sullivan 1183.e5. Epub 2019 May 2. Modabber M, Darvish-Zargar M, Breton N, ­Szymanski AM, Turgunbaev M, L, Chung DD, Duong H, Aldave AJ, Turner A, Reston J. 2019 American Col- McCannel CA. Open Macular Holes Choremis J. Crystalline Keratopathy lege of Rheumatology/Arthritis Foun- are Lost Opportunities. Ophthalmol in Post-LASIK Ectasia: A Case Report. dation Guideline for the Screening, Retina. 2018 Aug;2(8):755–756. Epub Cornea. 2019 May;38(5):635–638. Monitoring, and Treatment of Juvenile 2018 May 4. Review. Idiopathic Arthritis-Associated Uveitis. Wykoff CC, Khurana RN, Lampen SIR, Arthritis Care Res (Hoboken). 2019 Jun;​ Demer JL, Clark RA. Functional anat- Noronha G, Brown DM, Ou WC, Sadda 71(6):703–716. Epub 2019 Apr 25. omy of extraocular muscles during SR; HULK Study Group. Suprachoroidal human vergence compensation of hor- Angeles-Han ST, Ringold S, ­Beukelman Triamcinolone Acetonide for Diabetic izontal heterophoria. J Neurophysiol. T, Lovell D, Cuello CA, Becker ML, Macular Edema: The HULK Trial. Oph- 2019 Jul 1;122(1):105–117. Epub 2019 Colbert RA, Feldman BM, Ho­ lland thalmol Retina. 2018 Aug;2(8):874–877. May 1. GN, Ferguson PJ, Gewanter H, Epub 2018 May 4. ­Guzman J, Horonjeff J, Nigrovic PA, Dervenis N, Coleman AL, Harris A, Kwon S, Borrelli E, Fan W, Ebraheem A, Ombrello MJ, Passo MH, Stoll ML, Wilson MR, Yu F, Anastasopoulos E, Marion KM, Sadda SR. Repeatability of ­Rabinovich CE, Sen HN, Schneider R, Founti P, Pappas T, Kilintzis V, ­Topouzis Fluorescence Lifetime Imaging Oph- ­Halyabar O, Hays K, Shah AA, ­Sullivan F. Factors Associated With Retinal thalmoscopy in Normal Subjects With N, ­Szymanski AM, Turgunbaev M, Vessel Diameters in an Elderly Popula- Mydriasis. Transl Vis Sci Technol. 2019 Turner A, Reston J. 2019 American Col- tion: the Thessaloniki Eye Study. Invest May 8;8(3):15. lege of Rheumatology/Arthritis Foun- Ophthalmol Vis Sci. 2019 May 1;​60(6):​ dation Guideline for the Screening, 2208–2217. Monitoring, and Treatment of Juvenile Bai X, Yang XJ, Chen L. Establishment of an induced pluripotent stem cell Idiopathic Arthritis-­Associated Uve- Holland GN, Van Natta ML, Golden- line (FDEENTi002-A) from a patient itis. Arthritis Rheumatol. 2019 Jun;​71(6):​ berg DT, Ritts R Jr, Danis RP, Jabs DA; with Best’s disease carrying c.888C>A 864–877. Epub 2019 Apr 25. Studies of Ocular Complications of mutation in BEST1 gene. Stem Cell Res. AIDS Research Group. Relationship 2019 Jul;38:101459. Epub 2019 May 9. Thorne AW, Rootman DB. Influence of Between Opacity of Cytomegalovirus surgical approach for decompression Retinitis Lesion Borders and Severity of Fan W, Nittala MG, Velaga SB, Hirano on lower eyelid position in thyroid eye Immunodeficiency Among People With disease. Orbit. 2019 Apr 25:1–3. T, Wykoff CC, Ip M, Lampen SIR, van AIDS. Invest Ophthalmol Vis Sci. 2019 Hemert J, Fleming A, Verhoek M, May 1;60(6):1853–1862. Trzeciecka A, Stark DT, Kwong JMK, Sadda SR. Distribution of Non-­ perfusion and Neovascularization on Piqueras M, Bhattacharya SK, Caprioli Sun MM, Gordon LK, Levinson RD. Ultra-Wide Field Fluorescein Angiogra- J. Comparative lipid profiling dataset of Implications of Birdshot-Like Uveitis on phy in Proliferative Diabetic Retinopa- the inflammation-induced optic nerve the Pathogenesis of Birdshot Chorio- thy (RECOVERY Study): Report 1. Am J regeneration. Data Brief. 2019 Apr 25;​ retinopathy. JAMA Ophthalmol. 2019 Ophthalmol. 2019 May 9. 24:103950. May 1;137(5):583–584. Fung S, Stewart RMK, Dhallu SK, Sim Ghasemi Falavarjani K, Habibi A, Anvari Wangsathaporn K, Tsui I. Commotio DA, Keane PA, Wilkins MR, Tuft SJ. P, Ghasemizadeh S, Ashraf Khorasani Retinae Resulting From Rubber Band Anterior segment optical coherence M, Shenazandi H, Sarraf D. Effect of Injury in Two Girls. Ophthalmic Surg tomographic angiography assessment segmentation error correction on opti- Lasers Imaging Retina. 2019 May 1;​ of acute chemical injury. Am J Ophthal- cal coherence tomography angiogra- 50(5):309–313. phy measurements in healthy subjects mol. 2019 May 9. and diabetic macular oedema. Br J Fatehi N, McCannel TA, Giaconi J, Nouri-Mahdavi K, Fatehi N, Ca­ prioli J. Ophthalmol. 2019 Apr 29. Ca­ prioli J, Law SK, Nouri-Mahdavi K. Longitudinal Macular Structure-­ Outcomes of Glaucoma Drainage Function Relationships in Glaucoma Glasgow BJ, Abduragimov AR. Device Surgery in Eyes with Treated and Their Sources of Variability. Am J Methods toward simplification of Uveal Melanoma. Ocul Oncol Pathol. Ophthalmol. 2019 May 9. time resolved fluorescence anisot- 2019 Jan;5(1):20–27. Epub 2018 May 2. ropy in proteins labeled with NBD (4-chloro-7-nitrobenzofurazan) adducts. MethodsX. 2019 Apr 29;6:998–1008.

94 UCLA STEIN EYE INSTITUTE | Research and Funding Alagorie AR, Verma A, Nassisi M, Demer JL, Clark RA. Translation and June 2019 Sadda SR. Quantitative Assessment of eccentric rotation in ocular motor mod- Kogachi K, Konstas A, Karanjia R, Choriocapillaris Flow Deficits in Eyes eling. Prog Brain Res. 2019;248:117–126. Sadun AA. Endovascular Stenting in with Advanced Age-Related Macular Epub 2019 May 23. a Transgender Patient With Idiopathic Degeneration Versus Healthy Eyes. Am Intracranial Hypertension. J Neuro­ J Ophthalmol. 2019 Sep;205:132–139. Gorin MB. When Genetics Can Point ophthalmol. 2019 Jun;39(2):247–248. Epub 2019 May 10. Researchers and Clinicians in New Directions. JAMA Ophthalmol. 2019 Liu X, Thung EG, Caprioli J, Law SK. Hong S, Yang H, Gardiner SK, Luo May 23. Combined Ab Externo Cyclopexy and H, Hardin C, Sharpe GP, Caprioli J, Cryopexy in Cyclodialysis Cleft Repair. ­Demirel S, Girkin CA, Liebmann JM, Sacconi R, Sarraf D, Garrity S, ­Freund J Glaucoma. 2019 Jun;28(6):568–574. Mardin CY, Quigley HA, Scheuerle AF, KB, Yannuzzi LA, Gal-Or O, ­Souied E, Fortune B, Chauhan BC, Burgoyne Sieiro A, Corbelli E, Carnevali A, Mohammadzadeh V, Galian K, CF. OCT-Detected Optic Nerve Head Querques L, Bandello F, Querques G. ­Martinyan J, Nouri-Mahdavi K. Vision Neural Canal Direction, Obliqueness Nascent Type 3 Neovascularization in Loss After Glaucoma Surgery: Pro- and Minimum Cross-Sectional Area in Age-Related Macular Degeneration. gressive Macular Thinning as a Sign of Healthy Eyes. Am J Ophthalmol. 2019 Ophthalmol Retina. 2018 Nov;2(11):​ Snuff-Out Phenomenon. J Glaucoma. May 13. 1097–1106. Epub 2018 May 25. 2019 Jun;28(6):e99–e102. Topouzis F, Founti P, Yu F, Wilson MR, Francone A, Yun L, Kothari N, Cheng I, Tepelus TC, Song S, Borrelli E, ­Nittala Coleman AL. Twelve-year incidence Farajzadeh M, Govetto A, Hubschman MG, Baghdasaryan E, Sadda SR, and baseline risk factors for pseudo­ JP. Lamellar Macular Holes in the Pres- Chopra V. Quantitative Analysis of exfoliation: The Thessaloniki Eye Study ence of Age-Related Macular Degener- Retinal and Choroidal Vascular Param- (An American Ophthalmological Soci- ation. Retina. 2019 May 27. eters in Patients With Low Tension ety Thesis). Am J Ophthalmol. 2019 Glaucoma. J Glaucoma. 2019 Jun;​28(6):​ May 13. Shi Y, Huang J, Baghdasaryan E, Huang P, Huang X, Sadda SR, Lee OL. 557–562. Aronow ME, Wiley HE, Gaudric A, Representation of Central Endothelial Parke DW 2nd, Coleman AL. New Data ­Krivosic V, Gorin MB, Shields CL, Cell Density by Analysis of Single Best Sets in Population Health Analytics. Shields JA, Jonasch EW, Singh AD, Specular Microscopy Image Regard- JAMA Ophthalmol. 2019 Jun 1;​137(6):​ Chew EY. Von Hippel-Lindau Disease: less of Cell Size Variance. Transl Vis Sci 640–641. Update on Pathogenesis and Systemic Technol. 2019 May 29;8(3):23. Aspects. Retina. 2019 May 14. Chanwimol K, Balasubramanian S, Ugradar S, Rootman DB. Orbital fat Nassisi M, Gaw SL, Janzen C, Sa­ rraf D, Chadha A, Volland S, Baliaouri NV, expansion in thyroid eye disease is Sadda SR, Tsui I. Retinal Vascular Tran EM, Williams DS. The route of the related to age. Eur J Ophthalmol. 2019 Changes During Pregnancy Detected visual receptor rhodopsin along the May 30:1120672119852322. With Optical Coherence Tomography ­cilium. J Cell Sci. 2019 May 15;132(10). Uji A, Nittala MG, Hariri A, Velaga SB, Angiography. Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2726–2732. Ugradar S, Lo C, Manoukian N, Sadda SR. Directional kinetics analysis ­Putthirangsiwong B, Rootman D. The of the progression of geographic atro- Kim EW, De Leon A, Jiang Z, Radu RA, Degree of Posttraumatic Enophthalmos phy. Graefes Arch Clin Exp Ophthalmol. Martineau AR, Chan ED, Bai X, Su WL, Detectable by Lay Observers. Facial 2019 Aug;257(8):1679–1685. Epub 2019 Montoya DJ, Modlin RL, Liu PT. Vita- Plast Surg. 2019 Jun;35(3):306–310. May 30. min A Metabolism by Dendritic Cells Epub 2019 May 17. Waldman AT, Yeshokumar AK, La­ very Triggers an Antimicrobial Response against Mycobacterium tuberculosis. Demer JL. Non-commutative, non­ A, Liu G, Pineles SL, Repka MX, Adang mSphere. 2019 Jun 5;4(3). linear, and non-analytic aspects of the L, Narula S, Liu GT. Validation of a ocular motor plant. Prog Brain Res. symptom-based questionnaire for Scott IU, VanVeldhuisen PC, Barton F, 2019;248:93–102. Epub 2019 May 20. pediatric CNS demyelinating diseases. Oden NL, Ip MS, Blodi BA, Worrall M, J AAPOS. 2019 Jun;23(3):157.e1–157.e7. Fish GE; Study of Comparative Treat- Zhang Y, Williams PR, Jacobi A, Wang Epub 2019 May 31. ments for Retinal Vein Occlusion 2 C, Goel A, Hirano AA, Brecha NC, Investigator Group. Patient-Reported ­Kerschensteiner D, He Z. Elevating Sharifipour F, Yazdani S, Asadi M, Saki Visual Function Outcomes After Growth Factor Responsiveness and A, Nouri-Mahdavi K. Modified Deep Anti-Vascular Endothelial Growth Fac- Axon Regeneration by Modulating Sclerectomy for the Surgical Treatment tor Therapy for Macular Edema Due Presynaptic Inputs. Neuron. 2019 Jul 3;​ of Glaucoma. J Ophthalmic Vis Res. to Central Retinal or Hemiretinal Vein 103(1):39–51.e5. Epub 2019 May 20. 2019 Apr–Jun;14(2):144–150. Occlusion: Preplanned Secondary Bhat SP. The developing ocular lens: Analysis of a Randomized Clinical Trial. A practical paradigm for probing chro- JAMA Ophthalmol. 2019 Jun 6. matin landscape and gene expression. Dev Biol. 2019 Sep 1;453(1):105–106. Epub 2019 May 23.

Research and Funding | UCLA STEIN EYE INSTITUTE 95 Barnes CS, Schuchard RA, Birch DG, Xu D, Nagiel A, Rahimy E, McCannel Kim JH, Rabiolo A, Morales E, Yu F, Afifi Dagnelie G, Wood L, Koenekoop RK, CA. Practice Patterns of Endophthalmi- AA, Nouri-Mahdavi K, Caprioli J. Risk Bittner AK. Reliability of Semiauto- tis Treatment: An International Survey Factors for Fast Visual Field Progres- mated Kinetic Perimetry (SKP) and of Retina Specialists. Ophthalmol Ret- sion in Glaucoma. Am J Ophthalmol. Goldmann Kinetic Perimetry in Children ina. 2018 Sep;2(9):979–980. Epub 2018 2019 Jun 22. and Adults With Retinal Dystrophies. Jun 14. Transl Vis Sci Technol. 2019 Jun 11;​ Daneshvar R, Yarmohammadi A, 8(3):36. Wang YE, Tepelus TC, Vickers LA, ­Alizadeh R, Henry S, Law SK, Ca­ prioli Baghdasaryan E, Gui W, Huang P, J, Nouri-Mahdavi K. Prediction of Shah SN, Kogachi K, Correa ZM, Irvine JA, Sadda S, Hsu HY, Lee OL. Glaucoma Progression with Structural Schefler AC, Aronow ME, Callejo Role of in vivo confocal microscopy in Parameters: Comparison of Optical SA, Cebulla CM, Day-Ghafoori S, the diagnosis of infectious keratitis. Int Coherence Tomography and Clinical ­Francis JH, Lally S, McCannel TA, Ophthalmol. 2019 Jun 17. Disc Parameters. Am J Ophthalmol. Paton KE, Phan IT, Pointdujour-Lim R, 2019 Jun 24. ­Ramasubramanian A, Rath P, Shields Xu X, Yannuzzi NA, Fernández-­ CL, Skalet AH, Wells JR, Jennelle RL, Avellaneda P, Echegaray JJ, Tran KD, Phalke SP, Huang Y, Rubtsova K, Berry JL. Trends in Radiation Prac- Russell JF, Patel NA, Hussain RM, ­Getahun A, Sun D, Reinhardt RL, tices for Female Ocular Oncologists in Sa­ rraf D, Freund KB. Differentiating O’Brien RL, Born WK. γδ T cells shape North America: A Collaborative Study Veins From Arteries on Optical Coher- memory-phenotype αβ T cell popu- of the International Society of Ocular ence Tomography Angiography by lations in non-immunized mice. PLoS Oncology. Ocul Oncol Pathol. 2019 Identifying Deep Capillary Plexus Vorti- One. 2019 Jun 25;14(6):e0218827. Jan;5(1):54–59. Epub 2018 Jun 12. ces. Am J Ophthalmol. 2019 Jun 19. Bhat SP, Gangalum RK, Kim D, ­Mangul Frausto RF, Chung DD, Boere PM, Lambert SR, Aakalu VK, Hutchinson S, Kashyap RK, Zhou X, Elashoff D. Swamy VS, Duong HNV, Kao L, ­Azimov AK, Pineles SL, Galvin JA, Heidary G, Transcriptional profiling of single R, Zhang W, Carrigan L, Wong D, Binenbaum G, VanderVeen DK. Intra- fiber cells in a transgenic paradigm Morselli M, Zakharevich M, Hanser ocular Lens Implantation during Early of an inherited childhood cataract EM, Kassels AC, Kurtz I, Pellegrini M, Childhood: A Report by the American reveals absence of molecular het- Aldave AJ. ZEB1 insufficiency causes Academy of Ophthalmology. Ophthal- erogeneity. J Biol Chem. 2019 Sep corneal endothelial cell state transition mology. 2019 Jun 20. 13;​294(37):13530–13544. Epub 2019 and altered cellular processing. PLoS Jun 26. One. 2019 Jun 13;14(6):e0218279. Chung DD, Zhang W, Jatavallabhula K, Barrington A, Jung J, Aldave AJ. Alter- ations in GRHL2-OVOL2-ZEB1 axis and aberrant activation of Wnt signal- ing lead to altered gene transcription in posterior polymorphous corneal dystrophy. Exp Eye Res. 2019 Jun 21;​ 188:107696.

96 UCLA STEIN EYE INSTITUTE | Research and Funding About the Institute About the Institute

stablished in 1966, the UCLA Stein Eye Institute vision-science campus is the fulfillment of a dream—an ambitious plan developed byJules Stein, MD, to Eprevent blindness by transforming the quality of vision research, education, patient care, and community outreach. The Institute exists because of Dr. Stein, one of the most influential executives in entertainment who returned to his roots as a medical doctor to become a national advocate for vision science; and Bradley R. Straatsma, MD, JD, founding director of the Stein Eye Institute and founding chairman of the UCLA Department of Oph- thalmology, who created a bold plan for building the scope of ophthalmology in the UCLA School of Medicine. Together Drs. Stein and Straatsma ensured that the Institute would take a central role in transforming vision science as a powerful plat- form for discovery and patient care to eradicate one of the great scourges of human existence: blindness. Under the leadership of Bartly J. Mondino, MD, director and chairman since 1994, the Institute’s core pillars have been increasingly developed and a broad agenda of program-building and expansion has been implemented. The first Stein Eye Center was opened in Santa Monica in 2012, and a historic part- nership—a first of its kind—was forged with the Doheny Eye Institute in 2013, creating the nation’s preeminent organization for ophthalmic care and vision research under the banner of the UCLA Department of Ophthalmology. Combined, the Stein Eye Institute, Stein Eye Center, Doheny Eye Center UCLA locations, and UCLA-affiliated hospitals provide patients across the Southland with access to the finest vision care. But perhaps most ambitious of all, the original dream for ophthalmology at UCLA has evolved into the Institute’s bold transformation to a vision-science campus—an interconnected community of facilities and people that merge research, training for new ophthalmologists, premier patient care, community outreach programs, and ongoing education for doctors worldwide. Since its opening on November 3, 1966, the Institute’s original mandate remains paramount: the relentless drive for excellence and the constant search for new pos- sibilities in the treatment of the eye. The Institute’s decades of accomplishments may have even exceeded the original soaring expectations of Dr. Stein who at the dedication ceremony defined his own prophecy for the Institute and the medical field he loved: “The men and women who will occupy this building and use its resources will share in future achievements that will outstrip any that have been seen; for science today is moving ahead with fantastic speed, and we must be sure that eye research moves with it. The history of this Institute begins with this dedication. I am confident that it will be a proud history.”

98 UCLA STEIN EYE INSTITUTE | About the Institute “If I am remembered for anything, it will not be for anything I did in show business, but for what I did to prevent blindness.”

DR. JULES STEIN

Doris and Jules Stein

The legacy of Dr. and Mrs. Jules Stein arises from their role in the 20th cen- tury as visionaries. Through brilliance and beneficence, they created a mul- titude of programs aimed specifically at one goal: preserving and restoring eyesight. They approached this task dauntlessly, integrating the worlds of business, medicine, and philanthropy in such a way as to enhance each and leave in trust the promise of limitless accomplishment in the advancement of eye research and treatment. The Stein Eye Institute was established as a result of their philanthropy.

About the Institute | UCLA STEIN EYE INSTITUTE 99 Board of Trustees

The Board of Trustees, established in 1977, ensures the Institute’s orderly growth and development. The Board meets regularly during the year, with each trustee providing his/her unique counsel. Collectively, their invaluable contributions have included fiscal planning for the Institute, adoption of measures to facilitate recruitment of the world’s finest vision scientists, allocation of funds for the purchase of vision research equipment, and recommendations for expansion programs.

Norman Abrams, Esq. Edward A. Landry, Esq. Bartly J. Mondino, MD Distinguished Professor Partner Director of Law Emeritus Musick, Peeler & Garrett Stein Eye Institute Acting Chancellor Emeritus 2016–present 1994–present UCLA 2015–present

Ronald L. Olson, Esq. Gerald H. Oppenheimer Nelson C. Rising, Esq. Partner President, Gerald Oppenheimer Chairman and Munger, Tolles & Olson Family Foundation Chief Executive Officer 1995–present President, Systems Design Rising Realty Partners Associates 2011–present 1992–present

Katrina vanden Heuvel Casey Wasserman Marissa Goldberg Publisher and Editor President and Chief Executive OBSERVER The Nation Officer Executive Director and 1984–present The Wasserman Foundation Chief Financial Officer 1998–present Doheny Eye Institute 2015–present

100 UCLA STEIN EYE INSTITUTE | About the Institute Executive Committee

The Executive Committee of the Stein Eye Institute and UCLA Department of Ophthalmology meets regularly during the year, with each member providing their unique expertise. The Committee ensures the orderly growth and development of the Institute and Department. It is involved in fiscal planning, expansion, recruitment, program development, and resolution of interdivisional issues.

Bartly J. Mondino, MD Director, Stein Eye Institute Chairman, UCLA Department of Ophthalmology Affiliation Chairman, Doheny Eye Institute

Anthony C. Arnold, MD Vice Chairman, Education

Anne L. Coleman, MD, PhD Vice Chairman, UCLA Department of Ophthalmology

SriniVas R. Sadda, MD President and Chief Scientific Officer, Doheny Eye Institute

Alfredo A. Sadun, MD, PhD Vice Chairman, Doheny Eye Center UCLA

Alapakkam P. Sampath, PhD Associate Director, Stein Eye Institute

Jonathan D. Smith Chief Administrative Officer, Stein Eye Institute

Gabriel H. Travis, MD Special Advisor

Mission Statement

The UCLA Stein Eye Institute is a vision-science campus dedicated to the preservation and restoration of vision through its global programs in innovative research, quality patient care, and multidisciplinary, integrative education, all with community outreach.

About the Institute | UCLA STEIN EYE INSTITUTE 101 Philanthropy for the Next 50 Years

For more than half a century, UCLA’s vision scientists have extended the boundaries of current knowledge to reach the goal of a lifetime of good vision for everyone. This noble undertaking has been due in large part to a strong tradition of philanthropy from private sources. Contributions from individuals, foundations, and corporations help underwrite priority needs, which uphold scientific innovation, patient care, training and education, and a strong commitment to community engagement. The Institute offers a variety of giving options to those who wish to promote and participate in this tradition of excellence.

Ways to Give Securities Bequests Gifts of appreciated securities are tax Making a gift through your will or living Direct Gifts deductible at their full market value. In trust gives you the immediate satisfac- Direct gifts—whether by cash, check, most cases, appreciation in the value tion of creating a lasting and personal or credit card—are critically important of the security benefits the University legacy that ensures Stein Eye’s future to Stein Eye because the gifts can be and is not taxable to the donor. and costs nothing now. put to work immediately, increasing Matching Gifts Charitable Gift Annuity their impact and extending their reach. Many corporations have demonstrated In exchange for a gift of cash or appre- Endowments their support by matching or multiply- ciated securities, you can receive fixed A gift of an endowment demonstrates ing their employees’ gifts up to a set income for life and an immediate char- a long-term commitment, since the amount. Before making a gift, you may itable income tax deduction. In addi- fund is maintained in perpetuity. A por- want to ask whether your employer tion, a portion of the annuity payments tion of the annual investment income participates in a matching gift program. is tax-free. is used to support clinical, educa- Certain restrictions apply to matching Qualified Retirement Plans gifts. Please consult your company’s tional, and scientific initiatives and the Naming The UCLA Foundation as a personnel office. remaining investment yield is returned beneficiary of some or all of your quali- to principal, thus, over the years, the Real Estate fied retirement plan may help you min- fund can grow and provide continuous Real estate (your primary residence, imize taxes and maximize your philan- support. vacation home, commercial property, thropic impact, while leaving to your An endowment serves as an endur- or land) is an asset that you can lever- loved ones, assets that are less taxed. ing legacy as it can bear the donor’s age in a variety of ways to support the Tribute Gifts name or honor a loved one. Giving Institute while reducing taxes and elim- Contributions may be made in mem- opportunities exist for endowed chairs, inating the burden of maintaining or ory, honor, or celebration of a loved endowed fellowships, and endowed selling your property. You can also use one, or to commemorate a special funds for research, education, and real estate to fund gifts that provide occasion. Donations can be used for patient care. These funds can be made you with an income stream for life. payable for up to five years. unrestricted program support or be directed to any area of the Institute. Pledges A pledge is a formal statement of intention to make a gift. Donors who seek to defer the bulk of their giving Your Gift Can Make a Difference until a future date, or who want to give However you choose to support the Institute, you will be embarking on a partnership via installments over time, may use with one of the world’s preeminent eye research centers. Such an investment will this giving strategy. A pledge may be greatly expand our understanding of the causes of eye diseases, expose alternative followed by an immediate gift or may treatment options, and ultimately prevent blindness. simply confirm your intention to make a For information on how to incorporate the UCLA Stein Eye Institute into your gift in the future. Pledges are typically estate and retirement planning, or to make a gift of any kind, please contact: made in concert with a preliminary first installment and provide a source of UCLA Stein Eye Institute consistent and dependable funding. Development Office This method often allows donors to 100 Stein Plaza, Room 1-124 give more generously than they may Los Angeles, California 90095-7000 have originally considered. Phone: (310) 206-6035 Fax: (310) 794-1665 [email protected]

102 UCLA STEIN EYE INSTITUTE | About the Institute UCLA Stein Eye Institute ANNUAL REPORT

July 1, 2018–June 30, 2019

DIRECTOR Bartly J. Mondino, MD

MANAGING EDITOR Tina-Marie Gauthier c/o Stein Eye Institute 100 Stein Plaza, UCLA Los Angeles, California 90095–7000 [email protected]

PUBLICATION COMMITTEE Anthony C. Arnold, MD Kevin M. Miller, MD Alfredo A. Sadun, MD, PhD Alapakkam P. Sampath, PhD M. Gail Summers

CONTRIBUTING EDITORS Teresa Closson Susan Ito Sarah Johnson Peter J. López Ellen Pascual

CONTRIBUTING WRITERS Dan Gordon Harlan Lebo

PHOTOGRAPHY Reed Hutchinson Robin Weisz

DESIGN Robin Weisz/Graphic Design

PRINTING Marina Graphic Center

To view the Annual Report online, visit: www.uclahealth.org/Eye/annual-report

For more information about the UCLA Department of Ophthalmology, see: www.uclahealth.org/eye/

©2019 by the Regents of the University of California. All rights reserved. UCLA STEIN EYE INSTITUTE

ANNUAL REPORT 2018–2019

ANNUAL REPORT 2018–2019ANNUAL REPORT

E R N E W F R O N T I S I N V I S I O N O R I N G C A R E E X P L

UCLA DEPARTMENT OF OPHTHALMOLOGY DAVID GEFFEN SCHOOL OF MEDICINE AT UCLA UCLA Stein Eye Institute Vision-Science Campus