The Journalof

VOLUME232 PHARMACOLOGY

FEBRUARY 1985 AND EXPERIMENTAL THERAPEUTICS CONTENTS

Effects of Drugs on Schedule-Controlled Behavior in Rats during Chronic Administration. S. K. RastOgi and D. E. McMillan 295 Vascular Effects of Physalia phyaalis Venom in the Skeletal Muscle of the Dog. Jose S. Laredo, Ramon R. Gonzalez, Jr. and David A. Hessinger 301

Indomethacin, Prostaglandin E5 and Transmission at the Frog Neuromuscular Junction. Kathleen Shaver Madden Downloaded from and William Van der Kloot 305 Ethanol-Induced Changes in Hydroxylase Activity in Adrenal Glands of Mice Selectively Bred for Differences in Sensitivity to Ethanol. Thomas A. French, Joseph M. Masserano and Norman Weiner 315 Mechanism by which Serotonin Attenuates Contractile Response of Canine Mesenteric Arterial Smooth Muscle. Robert S. Moreland, Cornelis van Breemen and David F. Bohr 322 jpet.aspetjournals.org Calcium Utilization in the Vasoconstriction to Enantiomers of SK&F 89748-A. William D. Matthews, Richard A. Macia, Jan Jacob Beckeringh, Robert M. DeMarinis, Adriaan de Jonge, Martin J. M. C. Thoolen, Bob Wilffert, Pieter B. M. W. M. Timmermans and P. A. van Zwieten 330 Elevated Brain Tryptophan and Enhanced 5-Hydroxytryptamine Turnover in Acute Hepatic Heme Deficiency: Clinical Implications. David A. Litman and Maria Almira Correia 337 Propranolol-Induced Elevation of Pulmonary Collagen. R. C. Lindenschmidt and H. P. Witschi 346

Performance Maintained by Orally Delivered under Second-Order, Tandem and Fixed-Interval at ASPET Journals on September 25, 2021 Schedules in Fond-Satiated and Food-Deprived Rhesus Monkeys. Marilyn E. Carroll 351 Regional Blood Flow Changes in Response to Mildly Presser Doses of Triglycyl Desamino Lysine and Arginine Vasopressin in the Conscious Dog. Mohammed M. Moursi, David G. L van Wylen and Louis G. D’Alecy 360 Systemic and Coronary Hemodynamic Effects of Pinacidil, a New Antihypertensive Agent, in Awake Dogs: Comparison with Hydralazine. Seinosuke Kawashima and Chang-Seng Liang 369 Effects of Nisoldipine on Cardiocirculatory Dynamics and Cardiac Output Distribution in Conscious Rats at Rest and during Treadmill Exercise. Helmut Drexler, Stephen F. Flaim, Ronald H. Fields and Robert Zelis 376 Reversal by the Calcium Antagonist Nisoldipine of Norepinephrine-Induced Reduction of GFR: Evidence for Preferential Antagonism of Preglomerular Vasoconstriction. Rodger Loutzenhiser, Murray Epstein, Charles Horton and Philip Sonke 382 Amphetamine Attenuates the Stimulated Release of in Vivo. Werner G. Kuhr, Andrew G. Ewing, Joseph A. Near and R Mark Wightman 388 Role ofAlpha Adrenoceptor Activation in Modulating the Murine Primary Antibody Response in Vitro. Virginia M. Sanders and Albert E. Munson 395 Effects of Ethanol and Other Intoxicant-Anesthetics on Voltage-Dependent Sodium Channels of Brain Synapto- somes. R. Adron Harris and Patrick Bruno 401 Cardiovascular Effects of Losulazine Hydrochloride, a Peripheral Norepinephrine-Depleting Agent, in Nonhuman Primates. Donald T. Pals and Garry L DeGraaf 407 Actions of Ethanol on Voltage-Sensitive Sodium Channels: Effects on Neurotoxin-Stimulated Sodium Uptake in Synaptosomes. Michael J. Mullin and Walter A. Hunt 413 Reactivity and Possible Significance of Hydroxylamine and Nitroso Metabolites of Procainamide. Jack P. Uetrecht 420 Kinetics of Drug Action in Disease States. IV. Effect of Pregnancy on Phenobarbital Concentrations at Onset of Loss of Righting Reflex in Rats. Meindert Danhof and Gerhard Levy 426 Kinetics of Drug Action in Disease States. V. Acute Effect of Urea Infusion on Phenobarbital Concentrations in Rats at Onset of Loss of Righting Reflex. Meindert Danhof and Gerhard Levy 430

contents Continued on iv Contents Continued from iii

Kinetics of Drug Action in Disease States. VI. Effects of Experimental Diabetes on Phenobarbital Concentrations in Rats at Onset of Loss of Righting Reflex. Meindert Danhof, Masafumi Hisaoka and Gerhard Levy 435 Neurochemical and Functional Correlates of Naltrexone-Induced Opiate Receptor Up-Regulation. Ann Tempel, Eliot L. Gardner and R. Suzanne Zukin 439 Taurine Modulation of Calcium Binding to Cardiac Sarcolemma. Leslie A. Sebring and Ryan J. Huxtable 445 Stereoselective Behavioral Effects of N-Allylnormetazocine in Pigeons and Squirrel Monkeys. Jonathan L. Katz, Roger D. Spealman and Rodney D. Clark 452 High-Affinity Load Binding Proteins in Rat Kidney Cytosol Mediate Cell-Free Nuclear Translocation of Load. Prakash Mistry, George W. Lucier and Bruce A. Fowler 462 Deficiency in 15-Hydroxyprostaglandin Dehydrogenase Activity after Unilateral Ureteral Obstruction of the Dog Kidney. Patrick Y.-K. Wong, Joseph P. Pieroni, Patricia H.-W. Chao, Donald Sarubbi, Donald N. Marion, Craig T. Albanase and E. Darracott Vaughan, Jr 470 Chronic Ethanol and (Na-K)-Adenosine Triphosphatase: Apparent Adaptation in Cation Binding and Enzyme Conformation. Alan C. Swann 475

Enhanced Adverse Electrophysiologic Effects of Histamine after Myocardial Infarction in Guinea Pigs. John S. Downloaded from

Cameron, Marion S. Gaide, Philip L. Goad, Cynthia B. Altman, Javier Cuevas, Robert J. Myerburg and Arthur L. Bassett .. 480 Electrophysiologic Effects ofAmioride in Canine Purkinje Fibers: Evidence for a Delayed Effect on Repolarization. Anne Curtis Marchese, Joseph A. Hill, Jr., Pu-Di Xie and Harold C. Strauss 485 Evidence for Autoreceptor Modulation of Endogenous Dopamine Release from Rabbit Caudate Nucleus in Vitro. Eric M. Parker and Luigi X. Cubeddu 492 Pantoyl-y-Aminobutyric Acid Facilitates Cholinergic Function in the Central Nervous System. Masanobu Nakahiro, jpet.aspetjournals.org Norihisa Fujita, Isao Fukuchi, Kihachi Saito, Tsuyoshi Nishimura and Hiroshi Yoshida 501 Involvement of Epinephrine in the Presynaptic Beta Adrenoceptor Mechanism of Norepinephrine Release from Rat Hypothalamic Slices. Hiroshi Ueda, Yoshio Goshima, Takao Kubo and Yoshimi Misu 507 9-Tetrahydrocannabinol Decreases Turnover of Brain Histamine. Ryozo Oishi, Yoshinori Itoh, Masahiro Nishibori and Kiyomi Saeki 513

Relative Selectivity of 6, 7-Dihydroxy-2-Dimethylaminotetralin, N-n-Propyl-3-(3-Hydroxyphenyl) Piperidine, N- at ASPET Journals on September 25, 2021 Propylnorapomorphine and as Agonists at Striatal Dopamine Autoreceptors and Postsynaptic Dopa- mine Receptors. Yves Claustre, Dominique Fage, Branimir Zivkovic and Bernard Scatton 519 Presynaptic Opioid Receptor Subtypes in the Rabbit Ear Artery. Peter Illes, Norbert Pfeiffer, Ivar von Kugelgen and Klaus Starke 526 On the Pharmacology of L-645,151: A Topically Effective Ocular Hypotensive Carbonic Anhydrase Inhibitor. M. F. Sugrue, P. Gautheron, C. Schmitt, M. P. Viader, P. Conquet, R. L. Smith, N. N. Share and C. A. Stone 534 Pharmacological Evaluation of Purified Component and Whole-Cell Pertussis Vaccine in the Cardiovascular System of Rats. D. J. de Wildt, Y. de Jong, F. P. Nijkamp and J. G. Kreeftenberg 541 Dual Effect of Dynorphin-(l-13) on Cholinergic and Substance P-ergic Transmissions in the Rabbit Iris Sphincter Muscle. Naoko Ueda, Ikunobu Muramatsu and Motohatsu Fujiwara 545 Dual Effect of Ouabain on the Palytoxin-Induced Contraction and Norepinephrine Release in the Guinea-Pig Vas Deferens. Y. Ishida, A. Kajiwara, K. Takagi, Y. Ohizumi and S. Shibata 551 Inhibitory Effect of OUabain on the Palytoxin-Induced Contraction of Human Umbilical Artery. Y. Ishida, N. Satake, J. Habon, H. Kitano and S. Shibata 557 Localization of Beta Adrenoceptor Subtypes in Rat Kidney by Light Microscopic Autoradiography. Roger J. Summers, Jennifer A. Stephenson and Michael J. Kuhar 561 Acrylonitrile-Induced Gastric Mucosal Necrosis: Role of Gastric Glutathione. B. I. Ghanayem, P. J. Boor and A. E. Ahmed 570