Abstracts for the Xiith National Congress of Anatomy with International Participation, 29Th October - 1St November 2008, Mersin, Turkey

Total Page:16

File Type:pdf, Size:1020Kb

Abstracts for the Xiith National Congress of Anatomy with International Participation, 29Th October - 1St November 2008, Mersin, Turkey Abstracts www.anatomy.org.tr doi:10.2399/ana.08.019 Abstracts for the XIIth National Congress of Anatomy with International Participation, 29th October - 1st November 2008, Mersin, Turkey Anatomy 2008; 2 Suppl: 19-80, © 2008 TSACA Invited Lectures and Conferences (C-01 — C-13) (Panel 1-3) C-01 C-05 Archeological Wealth of Kilikia Region Phylogenesis and architecture of the telencephalon investigated by in-vivo tractography Durugönül S* Valavanis A* Mersin University, Faculty of Fine Arts, Mersin, Turkey. University Hospital Zurich, Institute of Neuroradiology, Zurich, Switzerland. C-02 History of neuroanatomy in Anatolia C-06 Türe U* Fiber tractography – Clinical applications Yeditepe University, Faculty of Medicine, Department of Türe U* Neurosurgery, Istanbul, Turkey. Yeditepe University, Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey. C-03 C-07 The Impact of neuro-anatomy on the evolution of The impact of cisternal-anatomy on microneurosurgical neurosurgery explorations (Video) Yaflargil G* Yaflargil G* University of Arkansas for Medical Sciences, Department of *University of Arkansas for Medical Sciences, Department of Neurosurgery, USA. Neurosurgery, USA. C-08 C-04 Architectonic organization of the basal subarachnoid Structure of the brain's white matter space investigated by neuroradiological techniques Türe U* Valavanis A* Yeditepe University, Faculty of Medicine, Department of University Hospital Zurich, Institute of Neuroradiology, Zurich, Neurosurgery, Istanbul, Turkey. Switzerland. Copyright © 2008 Turkish Society of Anatomy and Clinical Anatomy (TSACA). All rights reserved. Published by Deomed Medical Publishing, Istanbul. 20 XIIth National Congress of Anatomy, 29th October - 1st November 2008, Mersin, Turkey C-09 C-13 Neuro-visualization of the skull-base Ethic principles in scientific publications Angtuaco E* Ruacan fi *University of Arkansas for Medical Sciences, Department of *Hacettepe University, Faculty of Medicine, Department of Radiology, USA. Pathology, Ankara, Turkey. Panel-1 C-10 Novelties in neuroanatomy education Neurovisualization of the white matter diseases Weiglein A*, Koebke J** Angtuaco E* Karl-Franzens-University, Institute of Anatomy*, Graz, Austria; University of Cologne, Institute II for Anatomy**, Cologne, Germany. *University of Arkansas for Medical Sciences, Department of Radiology, USA. Panel-2 Problems in cadaver obtaining, possible solutions C-11 Elhan A,* fieker M **, Yeflilyurt H***, Dinç AH**** Vascular anatomy of the CNS Ankara University, Faculty of Medicine, Department of Anatomy*, Ankara, Turkey; Selcuk University, Meram Faculty of Medicine, Yaflargil G* Department of Anatomy**, Konya, Turkey; Counselor Assistant of *University of Arkansas for Medical Sciences, Department of Ministry of Health ***; Ankara, Turkey; President of Ankara Council of Forensic Medicine ***, Ankara, Turkey. Neurosurgery, USA. Panel-3 C-12 Evaluation on academic promotion criteria Brain eye Akflit MD*, Akk›n SM **, Sars›lmaz M*** Hacettepe University, Faculty of Medicine, Department of Anatomy*, Yaflargil G* Ankara, Turkey; Istanbul University, Cerrahpafla Faculty of Medicine, *University of Arkansas for Medical Sciences, Department of Department of Anatomy**, Istanbul, Turkey; F›rat University, Faculty Neurosurgery, USA. of Medicine, Department of Anatomy***, Elaz›¤, Turkey. Anatomy 2008; 2 Abstracts 21 Oral Presentations (O-01 — O-28) O-01 latex under pressure. The specimens were fixed in 10% Basilar artery angulation and vertigo due to the hemo- formaldehyde solution. The basilar artery and its branches dynamic effect of dominant vertebral artery were produced under a stereoscopic microscope. In our study, Coflar M*, Yaman M*, Eser O*, Songur A*, Özen OA* we defined the anterior inferior cerebellar artery (AICA), the superior cerebellar artery (SCA) and the posterior cerebral Afyon Kocatepe University, Faculty of Medicine, Department of Anatomy*, Afyon, Karahisar, Turkey. artery (PCA) whose arterial territories are well known and which are larger in diameter than the other branches of the basilar artery as the major branches, where as the labyrinthine Vertebral arteries form the basilar artery at the pontobulbar artery and the pontine branches were defined as the minor junction. The vertebral artery may have dominancy in one of branches. We examined the minor branches as the perforating them. The branches of basilar artery supply blood for the branches and the cranial nerve branches which were classified vestibular nuclei and its connections. Vertigo is seen generally variously until now The understanding of the vascular pattern in the upper middle aged patients. Vertigo can be observed in of the posterior fossa is unavoidable for preserving the branch- dolichoectasia of basilar artery such as angulation and elonga- es of the basilar artery during surgery and preventing many tion, because of the diminished blood supply and changed complications and also comprehending some vascular syn- hemodynamic factors of vestibular nuclei and its connections. dromes associated with the occlusion of the various groups of We hypothesized that angulation or elongation of basilar branches. The minor branches can be affected by some neu- artery can be estimated according to the unilateral vertebral rovascular diseases so understanding of the distrubution of artery dominant hypertensive patients. The basilar artery can minor branches is essential for safe neurosurgical operations. angulate from the dominant side of vertebral artery to the Key words: Basilar artery, pontine branches, labyrinthine recessive side. These angulation and elongation can effect the artery, trigeminal nerve. hemodynamic factors in absence of growing collateral arteries. So, the vertigo attacks may occur in these patients. Key words: Dominant vertebral artery, basilar artery angula- tion, vertigo. O-03 The anatomy and clinical significans of the trigeminocerebellar artery fien T*, Tüccar E*, Esmer AF* O-02 Ankara University, Faculty of Medicine, Department of Anatomy*, The anatomy of the minor branches of the basilar artery Ankara, Turkey. fien T*, Tüccar E* Ankara University, Faculty of Medicine, Department of Anatomy*, The trigeminocerebellar artery (TCA) which branched from Ankara, Turkey. basilar artery supplies both the trigeminal nerve root and the cerebellar hemisphere. The previous studies provide insuffi- The pontine arteries arise from the basilar artery which is quite cient data about the prevalence of this artery. In this study, we important for the posterior circulation of the brain. Various examined its course and origin. Fourty-five human brainstems classifications for the pontine arteries have been used by sever- were examined in this study. The vertebrobasilar arterial sys- al authors until now but this variety is confused. Also there is tem was injected with colored latex under pressure after liga- no adequate study about these branches. In this study, we tion of the posterior communicating arteries. The specimens decided to examine the pontine branches of the basilar artery. were fixed in 10% formaldehyde solution. The arteries were Fourty-five human brainstems were examined in this study. produced under a stereoscopic microscope. We observed the The vertebrobasilar arterial system was injected with colored TCA in 12 sides of the 45 brainstems (13.3%) in our study. We Anatomy 2008; 2 22 XIIth National Congress of Anatomy, 29th October - 1st November 2008, Mersin, Turkey distinguished the four segments of TCA; the pontine, trigemi- Key words: Oculomotor nerve, nerve compression, superior nal, cerebellopontine and the cerebellar segments. Although it cerebellar artery, posterior cerebral artery, variation. was mentioned that TCA originates from the same level of the superolateral pontine artery (superior trigeminal branch), we defined in our study that 10 of the arteries coursed like super- O-05 olateral pontine artery (superior trigeminal branch), 3 of them coursed like inferolateral pontine artery (inferior trigeminal NADPH-d and Fos reactivity following experimental artery). Also, TCA was bilaterally observed on one brainstem. spinal cord injury (hemisection) and embryonic neuronal In previous studies, it was indicated that TCA supplied the part stem cell transplantation of the cerebellum that is normally perfused by the anterior Da¤c› T*, Kayal›o¤lu G**, Keser A*, Önal A*** inferior cerebellar artery (AICA) so the TCA could be regard- Ege University, Faculty of Medicine, Department of Physiology*, ed as a hypoplastic AICA with higher origin. At the same time, Department of Anatomy**, Department of Pharmacology***, Izmir, the AICA was already present on the ipsilateral side with TCA Turkey. and agreed that TCA could represent a specific, unique branch of the basilar artery. In our study, we defined distinct results about TCA, especially its prevalence and origin in a large series In this study, the role of nitric oxide (NO) in neuropathic pain of cadavers. and the effect of embryonic neural stem cell (ENSC) trans- plantation on NO content in spinal cord neurons were investi- Key words: Trigeminocerebellar artery,basilar artery, trigem- gated by administration of NO donor L-arginine and NO syn- inal nerve, trigeminal neuralgia. thase inhibitor L-NAME in rats after spinal cord injury (SCI) as well as in rats with ENSC transplantation. 3 groups of Sprague-Dawley rats were used (n=30 each): control (laminec- O-04 tomy), SCI (hemisection at T12-T13), SCI + ENSCT. Neurovascular relationship and variations of the oculo-
Recommended publications
  • Chapter 20 *Lecture Powerpoint the Circulatory System: Blood Vessels and Circulation
    Chapter 20 *Lecture PowerPoint The Circulatory System: Blood Vessels and Circulation *See separate FlexArt PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Introduction • The route taken by the blood after it leaves the heart was a point of much confusion for many centuries – Chinese emperor Huang Ti (2697–2597 BC) believed that blood flowed in a complete circuit around the body and back to the heart – Roman physician Galen (129–c. 199) thought blood flowed back and forth like air; the liver created blood out of nutrients and organs consumed it – English physician William Harvey (1578–1657) did experimentation on circulation in snakes; birth of experimental physiology – After microscope was invented, blood and capillaries were discovered by van Leeuwenhoek and Malpighi 20-2 General Anatomy of the Blood Vessels • Expected Learning Outcomes – Describe the structure of a blood vessel. – Describe the different types of arteries, capillaries, and veins. – Trace the general route usually taken by the blood from the heart and back again. – Describe some variations on this route. 20-3 General Anatomy of the Blood Vessels Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Capillaries Artery: Tunica interna Tunica media Tunica externa Nerve Vein Figure 20.1a (a) 1 mm © The McGraw-Hill Companies, Inc./Dennis Strete, photographer • Arteries carry blood away from heart • Veins
    [Show full text]
  • A Unique Temporary Collateral Pathway Between Carotid-Vertebrobasilar
    Liu et al. BMC Neurology (2020) 20:97 https://doi.org/10.1186/s12883-020-01651-1 CASE REPORT Open Access A unique temporary collateral pathway between carotid-vertebrobasilar arteries in a carotid dissection patient Xiaogang Liu1†, Bing Li2†, Ying Liu3, Hongliang Wu2* , Huilong Zhang2, Lianwei Dou2 and Chuanyu Liu2 Abstract Background: In adults, the anastomosis between carotid and vertebrobasilar arteries is usually the posterior communicating artery, sometimes the primitive trigeminal artery. In this case, the basilar artery fed the internal carotid artery through the pontine-to-tentorial artery anastomosis after severe stenosis from traumatic carotid dissection. Case presentation: A 32-year-old female was diagnosed with ischemic stroke caused by traumatic carotid artery dissection. Aspirin (100 mg/day) and clopidogrel (75 mg/day) were prescribed. Digital subtraction angiography performed 6 days after stroke onset showed a dissection in the cervical segment of left internal carotid artery with severe local stenosis, and a collateral pathway from BA to the cavernous segment of internal carotid artery through the lateral pontine and tentorial artery. Without interventional therapy, clinical symptoms improved significantly within 10 days after onset. At 3-month follow-up, left common carotid artery angiography showed the stenosis had been significantly improved with a residual aneurysm. There was no collateral pathway between carotid-vertebrobasilar arteries, and a residual small artery originated from the posterior vertical segment of cavernous internal carotid artery. The small artery was clearly visualized by 3-dimensional rotational angiography and identified the tentorial artery. Conclusion: To the author’s knowledge, this is the first report of a collateral pathway between carotid vertebrobasilar arteries through the pontine-to-tentorial artery anastomosis.
    [Show full text]
  • Supplementary Table 1: Adhesion Genes Data Set
    Supplementary Table 1: Adhesion genes data set PROBE Entrez Gene ID Celera Gene ID Gene_Symbol Gene_Name 160832 1 hCG201364.3 A1BG alpha-1-B glycoprotein 223658 1 hCG201364.3 A1BG alpha-1-B glycoprotein 212988 102 hCG40040.3 ADAM10 ADAM metallopeptidase domain 10 133411 4185 hCG28232.2 ADAM11 ADAM metallopeptidase domain 11 110695 8038 hCG40937.4 ADAM12 ADAM metallopeptidase domain 12 (meltrin alpha) 195222 8038 hCG40937.4 ADAM12 ADAM metallopeptidase domain 12 (meltrin alpha) 165344 8751 hCG20021.3 ADAM15 ADAM metallopeptidase domain 15 (metargidin) 189065 6868 null ADAM17 ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) 108119 8728 hCG15398.4 ADAM19 ADAM metallopeptidase domain 19 (meltrin beta) 117763 8748 hCG20675.3 ADAM20 ADAM metallopeptidase domain 20 126448 8747 hCG1785634.2 ADAM21 ADAM metallopeptidase domain 21 208981 8747 hCG1785634.2|hCG2042897 ADAM21 ADAM metallopeptidase domain 21 180903 53616 hCG17212.4 ADAM22 ADAM metallopeptidase domain 22 177272 8745 hCG1811623.1 ADAM23 ADAM metallopeptidase domain 23 102384 10863 hCG1818505.1 ADAM28 ADAM metallopeptidase domain 28 119968 11086 hCG1786734.2 ADAM29 ADAM metallopeptidase domain 29 205542 11085 hCG1997196.1 ADAM30 ADAM metallopeptidase domain 30 148417 80332 hCG39255.4 ADAM33 ADAM metallopeptidase domain 33 140492 8756 hCG1789002.2 ADAM7 ADAM metallopeptidase domain 7 122603 101 hCG1816947.1 ADAM8 ADAM metallopeptidase domain 8 183965 8754 hCG1996391 ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma) 129974 27299 hCG15447.3 ADAMDEC1 ADAM-like,
    [Show full text]
  • Vessels and Circulation
    CARDIOVASCULAR SYSTEM OUTLINE 23.1 Anatomy of Blood Vessels 684 23.1a Blood Vessel Tunics 684 23.1b Arteries 685 23.1c Capillaries 688 23 23.1d Veins 689 23.2 Blood Pressure 691 23.3 Systemic Circulation 692 Vessels and 23.3a General Arterial Flow Out of the Heart 693 23.3b General Venous Return to the Heart 693 23.3c Blood Flow Through the Head and Neck 693 23.3d Blood Flow Through the Thoracic and Abdominal Walls 697 23.3e Blood Flow Through the Thoracic Organs 700 Circulation 23.3f Blood Flow Through the Gastrointestinal Tract 701 23.3g Blood Flow Through the Posterior Abdominal Organs, Pelvis, and Perineum 705 23.3h Blood Flow Through the Upper Limb 705 23.3i Blood Flow Through the Lower Limb 709 23.4 Pulmonary Circulation 712 23.5 Review of Heart, Systemic, and Pulmonary Circulation 714 23.6 Aging and the Cardiovascular System 715 23.7 Blood Vessel Development 716 23.7a Artery Development 716 23.7b Vein Development 717 23.7c Comparison of Fetal and Postnatal Circulation 718 MODULE 9: CARDIOVASCULAR SYSTEM mck78097_ch23_683-723.indd 683 2/14/11 4:31 PM 684 Chapter Twenty-Three Vessels and Circulation lood vessels are analogous to highways—they are an efficient larger as they merge and come closer to the heart. The site where B mode of transport for oxygen, carbon dioxide, nutrients, hor- two or more arteries (or two or more veins) converge to supply the mones, and waste products to and from body tissues. The heart is same body region is called an anastomosis (ă-nas ′tō -mō′ sis; pl., the mechanical pump that propels the blood through the vessels.
    [Show full text]
  • Arteries.Pdf
    Arteries Although blood vessels differ in size, distribution, and function, structurally they share many common features. As in the heart, the walls of blood vessels consist of three major coats or tunics. Differences in the appearance and functions of the various parts of the circulatory system are reflected by structural changes in these tunics or by reduction and even omission of some of the layers. From the lumen outward, the wall of a blood vessel consists of a tunica intima, tunica media, and tunica adventitia. The tunica intima corresponds to and is continuous with the endocardium of the heart. It consists of an endothelium of flattened squamous cells resting on a basal lamina and is supported by a subendothelial connective tissue. The tunica media is the equivalent of the myocardium of the heart and is the layer most variable both in size and structure. Depending on the function of the vessel, this layer contains variable amounts of smooth muscle and elastic tissue. The tunica adventitia also varies in thickness in different parts of the vascular circuit. It consists mainly of collagenous connective tissue and corresponds to the epicardium of the heart, but it lacks mesothelial cells. As arteries course away from the heart they undergo successive divisions to provide numerous branches whose calibers progressively decrease. The changes in size and the corresponding changes in structure of the vessel wall are continuous, but three classes of arteries can be distinguished: large elastic or conducting arteries, medium-sized muscular or distributing arteries, and small arteries and arterioles. A characteristic feature of the entire arterial side of the blood vasculature system is the prominence of smooth muscle in the tunica media.
    [Show full text]
  • 27 Lymph Vascular System
    Lymph Vascular System The lymph vascular system consists of endothelial-lined tubes that recover intercellular (tissue) fluid not picked up by the blood vascular system and returns it to the blood. The fluid (lymph) carried by the lymphatics is a blood filtrate formed as fluid crosses the blood capillaries into the tissues. Unlike the blood vascular system, lymph flow is unidirectional - from tissues to the union of the lymphatic and blood vascular systems at the base of the neck. The lymphatic vascular system begins in the tissues as blindly ending capillaries that drain into larger collecting vessels and then into two main lymphatic trunks. Lymph nodes occur along the course of the vessels and filter the lymph. Lymphatics are present in most tissues but are absent from bone marrow, the central nervous system, coats of the eye, internal ear, and fetal placenta. Lymph Capillaries Lymph capillaries are thin-walled, blind tubes that branch and anastomose freely to form a rich network in organs and tissues. They are wider and more irregular than blood capillaries. The wall of a lymph capillary consists only of a thin continuous endothelium and a discontinuous basal lamina that is present only in patches or may even be absent. Adjacent endothelial cells may overlap, but junctional complexes are few and clefts occur between the cells. Externally, the endothelium is surrounded by a small amount of collagenous connective tissue. Fine filaments run perpendicularly from the collagen bundles and attach to the outer surfaces of the endothelium as anchoring filaments that maintain the patency of the vessel. Collecting Lymph Vessels Collecting lymph vessels differ from lymph capillaries in size and the thickness of their walls.
    [Show full text]
  • Camelus Dromedarius, Linnaeus 1758)
    Int. J. Morphol., 37(3):1095-1100, 2019. Morphological Configuration and Topography of the Brain Arterial Supply of the One-humped Camel (Camelus dromedarius, Linnaeus 1758) Configuración Morfológica y Topografía del Suministro Arterial del Encéfalo del Camello de una Joroba (Camelus dromedarius, Linnaeus 1758) Hassen Jerbi1; Noelia Vazquez2 & William Pérez2 JERBI, H.; VAZQUEZ, N. & PÉREZ, W. Morphological configuration and topography of the brain arterial supply of the one-humped camel (Camelus dromedarius, Linnaeus 1758). Int. J. Morphol., 37(3):1095-1100, 2019. SUMMARY: This study investigated the anatomy of the arteries of the brain, including the arterial circle of the brain, its branches and junctions, in five camel (Camelus dromedarius, Linnaeus 1758) following intravascular injection of colored latex via common carotid artery. The course and distribution of the arterial supply to the brain was described and morphological analysis was made. The basilar artery contributed to the blood supply of the brain in the camel in contrast to the situation in other Artiodactyla order. KEY WORDS: Anatomy; Blood vessels; Camelidae; Circulatory system; Cerebral arterial circle. INTRODUCTION Nearly 400 years ago, Thomas Willis gave the most the cerebral arterial circle (circle of Willis) (Kanan, 1970; Smuts detailed anatomic description of the arterial anastomosis at & Bezuidenhout, 1987; Ocal et al., 1999). the base of the brain, surrounded by cerebrospinal fluid. The arterial anastomotic ring that connects the internal carotid The most detailed description of circulus arteriosus arteries, and vertebrobasilar circulation by communicating cerebri was published by Kanan, but this work don´t showed arteries is called circle arteriosus cerebri. In humans and black photographs and topography by sections of these vessels in bears, blood supply to the brain is provided by two internal relation to the different parts of the head and encephalon.
    [Show full text]
  • Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease
    Downloaded from http://cshperspectives.cshlp.org/ on October 1, 2021 - Published by Cold Spring Harbor Laboratory Press Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease Aaron Buckley and Jerrold R. Turner Departments of Pathology and Medicine (Gastroenterology), Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115 Correspondence: [email protected] Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a selectively permeable barrier that supports nutrient absorption and waste secretion while preventing intrusion by luminal materials. Intestinal epithelia therefore play a central role in regulating interactions between the mucosal immune system and luminal contents, which include dietary antigens, a diverse intestinal microbiome, and pathogens. The paracellular space is sealed by the tight junction, which is maintained by a complex network of protein interactions. Tight junction dysfunction has been linked to a variety of local and systemic diseases. Two molecularly and biophysically distinct pathways across the intestinal tight junc- tion are selectively and differentially regulated by inflammatory stimuli. This review discusses the mechanisms underlying these events, their impact on disease, and the potential of using these as paradigms for development of tight junction-targeted therapeutic interventions. ucosal surfaces and the epithelial cells that adherens). The tight junction is a selectively Mline them are present at sites where tissues permeable barrier that generally represents the interface directly with the external environment rate-limiting step of paracellular transport. The or internal compartments that are contiguous adherens junction and desmosome provide es- with the external environment. Examples in- sential adhesive and mechanical properties that clude the gastrointestinal tract, the pulmonary contribute to barrier function but do not seal tree, and the genitourinary tract.
    [Show full text]
  • Quinone Oxidoreductase-1 in the Tight Junctions of Colonic Epithelial Cells
    BMB Rep. 2014; 47(9): 494-499 BMB www.bmbreports.org Reports Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells Seung Taek Nam1,#, Jung Hwan Hwang2,#, Dae Hong Kim1, Mi Jung Park1, Ik Hwan Lee1, Hyo Jung Nam1, Jin Ku Kang1, Sung Kuk Kim1, Jae Sam Hwang3, Hyo Kyun Chung4, Minho Shong4, Chul-Ho Lee2,* & Ho Kim1,* 1Department of Life Science, College of Natural Science, Daejin University, Pocheon 487-711, 2Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, 3Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Suwon 441-707, 4Department of Internal Medicine, Chungnam National University, Daejon 301-721, Korea NADH:quinone oxidoreductase 1 (NQO1) is known to be lating the intracellular ratio of NAD and NADH (two funda- involved in the regulation of energy synthesis and metabolism, mental mediators of energy metabolism) in various cell and the functional studies of NQO1 have largely focused on systems. NQO1 is also known as an antioxidant flavoprotein metabolic disorders. Here, we show for the first time that that scavenges reactive oxygen species (ROS) (3). Having pre- compared to NQO1-WT mice, NQO1-KO mice exhibited a viously shown that NQO1 activity is associated with cancer (4) marked increase of permeability and spontaneous inflammation and metabolic disorders, including diabetes and obesity (5), in the gut. In the DSS-induced colitis model, NQO1-KO mice we herein focused on the possible role of NQO1 in the gastro- showed more severe inflammatory responses than NQO1-WT intestinal tract. We report for the first time that the expression mice.
    [Show full text]
  • Vertebrobasilar Contribution to Cerebral Arterial System of Dromedary Camels (Camelus Dromedarius)
    ORIGINAL RESEARCH published: 11 June 2021 doi: 10.3389/fvets.2021.696707 Vertebrobasilar Contribution to Cerebral Arterial System of Dromedary Camels (Camelus dromedarius) Ahmad Al Aiyan 1*, Preetha Menon 1, Adnan AlDarwich 1, Moneeb Qablan 1, Maha Hammoud 1, Turke Shawaf 2 and Ken Richardson 3 1 Department of Veterinary Medicine, College of Food and Agriculture, United Arab Emirates University, Al Ain, United Arab Emirates, 2 Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Hasa, Saudi Arabia, 3 College of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, Perth, WA, Australia It is hypothesized that in the “more highly evolved” mammals, including the domesticated mammals, that the brainstem and the cerebellum receive arterial blood through the vertebrobasilar system whilst the internal carotid arteries primarily supply the forebrain. Edited by: In camels, the arterial blood supply to the brain differs from that of ruminants since the George M. Strain, internal carotid artery and the rostral epidural rete mirabile (RERM) are both present and Louisiana State University, United States the basilar artery contributes a significant proportion of cerebral afferent blood. In this Reviewed by: study, we described the anatomical distribution of the vertebrobasilar system arterial Michelle Osborn, supply in the dromedary. Secondly, we determined the direction of blood flow within the Louisiana State University, vertebral and basilar arteries using transcranial color doppler ultrasonography. Thirdly, we United States Louis R. Caplan, quantified the percentage arterial contributions of the carotid and vertebrobasilar systems Harvard Medical School, to the dromedary brain. Fifty-five heads of freshly slaughtered male Omani dromedaries United States aged 2–6 years were dissected to determine the distribution and topography of the *Correspondence: Ahmad Al Aiyan arterial distribution to the brain.
    [Show full text]
  • Defenders and Challengers of Endothelial Barrier Function
    REVIEW published: 18 December 2017 doi: 10.3389/fimmu.2017.01847 Defenders and Challengers of Endothelial Barrier Function Nader Rahimi* Department of Pathology, Boston University School of Medicine, Boston, MA, United States Regulated vascular permeability is an essential feature of normal physiology and its dysfunction is associated with major human diseases ranging from cancer to inflam- mation and ischemic heart diseases. Integrity of endothelial cells also play a prominent role in the outcome of surgical procedures and organ transplant. Endothelial barrier function and integrity are regulated by a plethora of highly specialized transmembrane receptors, including claudin family proteins, occludin, junctional adhesion molecules (JAMs), vascular endothelial (VE)-cadherin, and the newly identified immunoglobulin (Ig) and proline-rich receptor-1 (IGPR-1) through various distinct mechanisms and signaling. On the other hand, vascular endothelial growth factor (VEGF) and its tyrosine kinase receptor, VEGF receptor-2, play a central role in the destabilization of endothelial barrier function. While claudins and occludin regulate cell–cell junction via recruitment of zonula occludens (ZO), cadherins via catenin proteins, and JAMs via ZO and afadin, IGPR-1 recruits bullous pemphigoid antigen 1 [also called dystonin (DST) and SH3 protein inter- Edited by: acting with Nck90/WISH (SH3 protein interacting with Nck)]. Endothelial barrier function Thomas Luft, is moderated by the function of transmembrane receptors and signaling events that act University Hospital Heidelberg, Germany to defend or destabilize it. Here, I highlight recent advances that have provided new Reviewed by: insights into endothelial barrier function and mechanisms involved. Further investigation Luiza Guilherme, of these mechanisms could lead to the discovery of novel therapeutic targets for human University of São Paulo, Brazil diseases associated with endothelial dysfunction.
    [Show full text]
  • Estudio Del Receptor 2 De La Dopamina En Ovario Humano Y Efecto De Su Modulación Sobre El Síndrome De Hiperestimulación Ovárica”
    Facultad de Medicina y Odontología Departamento de Pediatría, Obstetricia y Ginecología. “Estudio del receptor 2 de la dopamina en ovario humano y efecto de su modulación sobre el Síndrome de Hiperestimulación Ovárica” Tesis doctoral presentada por: Francisco Manuel Delgado Rosas Dirigida por: Prof. Antonio Pellicer Martínez Dr. Raúl Gómez Gallego Prof. Francisco Gaytán Luna Tutor: Prof. Carlos Simón Vallés 290 F OBSTETRICIA I GINECOLOGIA II Valencia 2012 D. Antonio Pellicer Martínez, Catedrático del Departamento de Pediatría, Obstetricia y Ginecología de la Facultad de Medicina de la Universidad de Valencia. D. Raúl Gómez Gallego, Doctor en Ciencias Biológicas e Investigador contratado por la Fundación IVI. Valencia D. Francisco Gaytán Luna, Catedrático del Departamento de Biología Celular, Fisiología e Inmunología de la Facultad de Medicina de la Universidad de Córdoba. CERTIFICAN: Que el trabajo titulado: “Estudio del receptor 2 de la dopamina en ovario humano y efecto de su modulación sobre el Síndrome de Hiperestimulación Ovárica” ha sido realizado íntegramente por D. Francisco Manuel Delgado Rosas bajo nuestra supervisión. Dicho trabajo está concluido y reúne todos los requisitos para su presentación y defensa como TESIS DOCTORAL ante un tribunal. Y para que conste así a los efectos oportunos, firmamos la presente certificación en Valencia a 22 de Febrero de 2012. Fdo. Prof. Antonio Pellicer Martínez Fdo. Dr. Raúl Gómez Gallego Fdo. Prof. Francisco Gaytán Luna LISTA DE ABREVIATURAS AII: Angiotensina II ACE: Enzima convertidora de
    [Show full text]