GRIN2D Polyclonal Antibody Catalog # AP74331

10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609

Specification

GRIN2D Polyclonal Antibody - Product Information

Application WB Primary Accession O15399 Reactivity Human, Mouse, Rat Host Rabbit Clonality Polyclonal

GRIN2D Polyclonal Antibody - Additional Information

Gene ID 2906

Other Names Glutamate [NMDA] receptor subunit epsilon-4 (EB11) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D)

Dilution WB~~WB 1:500-2000, ELISA 1:10000-20000

Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Conditions -20℃

GRIN2D Polyclonal Antibody - Protein Information GRIN2D Polyclonal Antibody - Background

Component of NMDA receptor complexes that Name GRIN2D function as heterotetrameric, ligand-gated ion channels with high calcium permeability and Synonyms GluN2D, NMDAR2D voltage-dependent sensitivity to magnesium. Channel activation requires binding of the Function neurotransmitter glutamate to the epsilon Component of NMDA receptor complexes subunit, glycine binding to the zeta subunit, that function as heterotetrameric, ligand-gated ion channels with high calcium plus membrane depolarization to eliminate permeability and voltage-dependent channel inhibition by Mg(2+) sensitivity to magnesium. Channel (PubMed:9489750, PubMed:27616483, activation requires binding of the PubMed:26875626, PubMed:28126851). neurotransmitter glutamate to the epsilon Sensitivity to glutamate and channel kinetics subunit, glycine binding to the zeta subunit, depend on the subunit composition plus membrane depolarization to eliminate (PubMed:9489750).

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channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750).

Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein

GRIN2D Polyclonal Antibody - Protocols

Provided below are standard protocols that you may find useful for product applications.

• Western Blot • Blocking Peptides • Dot Blot • Immunohistochemistry • Immunofluorescence • Immunoprecipitation • Flow Cytomety • Cell Culture

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