Gastrin Detects Specificity: Analytical Big Reactivity with 7% Cross (G17); React Not Cross (G34); Does Gastrin with G13

Alphabetical Test Section 478X Immunochemiluminometric assay Immunochemiluminometric (ICMA) 10 pg/mL sensitivity: Analytical gastrin detects specificity: Analytical big reactivity with 7% cross (G17); react not cross (G34); does gastrin with G13. Clinical Background hormone is a polypeptide Gastrin gastric the cells of by the G secreted duodenal proximal and mucosa antral of potent stimulator Gastrin is a cells. has and also acid secretion, antral cells, the parietal actions on trophic cells, and enterochromaffin-like chief Gastrin mucosa. in the oxyntic cells food intake increase with levels age. acids) and amino (protein, acid with gastric decrease Levels secretion. (ZE syndrome In Zollinger-Ellison neoplasm a pancreatic syndrome), gastrin, of large amounts produces gastric excess in turn stimulates which ulcer disease. peptic and acid secretion non- but of pathological, A variety gastric in which disorders tumorous, to low also lead secretion is acid these gastrin; in blood elevations anemia pernicious include disorders with anacidity. atrophic gastritis and tests or calcium-stimulation Secretin- tumors in differentiating can assist antrum by the gastrin secreted from slight or moderate with in patients hypergastrinemia. Method • • • Specimen Requirements frozen serum 1 mL minimum 0.5 mL top preferred red No additive red top acceptable SST is required. fasting Overnight 81 100 pg/mL , and pepsid and pepsid , ®’ , Prilosec . 2000;79:379-411.) ®’ Atrophic gastritis with anacidity gastritis Atrophic Pernicious anemia Pernicious Gastrinoma • • • Differential diagnosis of peptic ulcer peptic of diagnosis Differential tumors and gastrin-secreting disease Diagnose gastrinoma Diagnose 5-7 y 13-64 interfere production. with gastrin Adults < Zollinger-Ellison syndrome: gastrin gastrin syndrome: Zollinger-Ellison et al. (Roy PK, >200 pg/mL levels Medicine Zantac Children Interpretive Information Interpretive Reference Range Reference Clinical Use Gastrin • •