Recombinant Mouse IL-36B/IL-36 Beta/IL-1F8 Protein

Home , IL36B, Interleukin, Interleukin 6

Leader in Biomolecular Solutions for Life Science

Recombinant Mouse IL-36b/IL-36 beta/IL-1F8 Protein

Catalog No.: RP00669 Recombinant

Sequence Information Background

Species Gene ID Swiss Prot Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins. It is a Mouse 69677 Q9D6Z6 cytokine that binds to and signal sthrough the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro- Tags inflammatory response. IL-36B is synthesized in several cells including resting and No tag activated monocytes, and Bcells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 beta is one part of the IL-36 Synonyms signaling system that is thought to be present in epithelial barriers and to take Il36b;Interleukin-36 beta;Interleukin-1 part in local inflammatory response; similar to the IL-1 system with which it shares family member 8;IL-1F8;Fil1e; Il1f8 the coreceptor IL1RAP. Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovialfibrobasts, articular chondrocytes and mature adipocytes, inducing expression of a number of antimicrobial peptides including Product Information beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases , inducing the production of proinflammatory cytokines in bone Source Purification marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha E. coli > 95% by SDS- and IL-23, and activating p38 MAPK phosphorylation in BMDCs. PAGE.

Endotoxin Basic Information < 1 EU/μg of the protein by LAL method. Description Recombinant Mouse IL-36b/IL-36 beta/IL-1F8 Protein is produced by E. coli Formulation expression system. The target protein is expressed with sequence (Ser31-Lys183) of mouse IL-36b/IL-36 beta/IL-1F8 (Accession #Q9D6Z6) fused with an initial Met Lyophilized from a 0.2 μm filtered at the N-terminus. solution of 20mM Tris,150mM Nacl,1mM EDTA,pH 8.0.Contact us for customized product form or Bio-Activity formulation. Storage Reconstitution Store the lyophilized protein at -20°C to -80 °C for long term. Reconstitute to a concentration of After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C 0.1-0.5 mg/mL in sterile distilled water. for up to 1 week. Avoid repeated freeze/thaw cycles.

Contact

www.abclonal.com Validation Data

Recombinant Mouse IL-36b/IL-36 beta/IL-1F8 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.