Brochure TMR Magnetic Stirrer with Fault Indicating System 01.2012

• Magnetic agitators with malfunction indicating system Dipl.-Ing. V. TEICHMANN stirring rod for applications in pharmaceutical production. Measurement, Control & Process Engineering • Metering units for conductivity and resistance of liquids. D - 35094 Lahntal - Kernbach • Temperature probes • Vacuum tight measuring lines passages • Special developments and production.

TMR magnetic stirrer with fault indicating system for the stirring staff combines the advantage of the magnetic drive with the safety of a mechanically coupled stirring unit.

Compact magnetic stirrer Table-top units - operation via front panel or remote control TMR-102-SK TMR-102-FSKV 7 x TMR-102-FSKV separated under a water bath

System magnetic stirrer Control unit and magnetic stirring unit separated MAGNETRONIC DSZ-5010 MAGNETRONIC DSS-50 TMR-102-S

Magnetic stirrer system on a mobile undercarriage with separate container trolley. MAGNETRONIC DSS-50 with TMR-102-S and TUW-DSS11 Front panel and connection panel MAGNETRONIC DSS-50

TMR -10 2-…: Magnetic drive field Ø 100 mm for stirring volumes up to 300 litre Page 1 TMR-202-…: Magnetic drive field Ø 200 mm for stirring volumes up to 1000 litre Subject to technical modifications 01.2012 • Magnetic agitators with malfunction indicating system Dipl.-Ing. V. TEICHMANN stirring rod for applications in pharmaceutical production. Measurement, Control & Process Engineering • Metering units for conductivity and resistance of liquids. D - 35094 Lahntal - Kernbach • Temperature probes • Vacuum tight measuring lines passages • Special developments and production.

Accessories for TMR magnetic stirrer NEW - Product container with special metal-fused glass flange in the base as maintenance-free storage for freewheeling Teflon stirring staffs.

Outstanding Advantages

• Practically wear-free operation of the stirring staff. No Teflon abrasion that would otherwise occur on stainless steel bases. • Dead-leg free. • Easy to clean and sterilise, CIP and SIP capable. • No bearing points to be monitored in the container, since stirring staffs are freewheeling. • Even small volumes can be stirred. • Perfect to discharge - Negligible product losses. • Stirring stuff and support flange can easily be adapted to different container sizes and geometries.

Cross section container

Container Base Screw O-ring seal Metal fused Teflon-coated Sample base plate seamless glass flange stirring staff tube

Page 2 Subject to technical modifications 01.2012 • Magnetic agitators with malfunction indicating system Dipl.-Ing. V. TEICHMANN stirring rod for applications in pharmaceutical production. Measurement, Control & Process Engineering • Metering units for conductivity and resistance of liquids. D - 35094 Lahntal - Kernbach • Temperature probes • Vacuum tight measuring lines passages • Special developments and production.

Accessories for TMR magnetic stirrers • Magnetic stirring staffs with Teflon sheathing. • Magnetic stirring staffs with stainless steel sheathing and ceramic bearing.

Magnetic stirring staffs of high quality and surface finish for use for pharmaceutical laboratory and production applications. • Hermetically sealed sheathing made of modified tetrafluoroethylene in a sintered or welded version.

• Food-safe in accordance with FDA CFR21, §175,300 and Food Contact Notification (FCN) No. 40.

• Thickness of the Teflon layer > 2 mm.

• Average Roughness Height Ra < 1 µ. • Central collar for clean concentricity.

• Magnetic core made of Alnico 500.

• Application temperature - 200 °C to + 250 °C.

• Pressure-resistant up to 3 bar absolute.

Freewheeling Teflon encapsulated stirring staffs

No. Type Description Recommended stirring volume 1 B 6060250 Stirring staff 40x40x250 mm with collar 100 x 60 x 60 mm Up to 1000 litre 2 B 34150 Stirring staff Ø 30 x 150 mm with collar Ø 34 x 30 mm 300 litre B 25155 Stirring staff Ø 22 x 155 mm with collar Ø 25 x 30 mm 200 litre 3 B 25110 Stirring staff Ø 22 x 110 mm with collar Ø 25 x 25 mm 100 litre 4 B 16100 Stirring staff Ø 14 x 100 mm with collar Ø16 x 20 mm 20 litre

Central stainless-steel encapsulated stirring staffs with ceramic bearings

No. Type Description Recommended stirring volume . 5 TER-4040210 Stirring staff 40 x 40 x 210 mm, T-DR3 coating 500 litre K 34/2 Stirring staff 40 x 40 x 210 mm, material 1.4435 3.1 B 500 litre 6 K 26/2 Stirring staff Ø 30 x 160 mm, material 1.4435 3.1 B 300 litre 7 K 22/2 Stirring staff Ø 26 x 130 mm, material 1.4435 3.1 B 200 litre

8 Ceramic bearings 10 +13 mm inner diameter, material CR101

NOTE The given stirring volumes refer to operation with TMR magnetic stirrers. Page 3 Subject to technical modifications 01.2012 Device and functional description

1. Introduction Page 4

The TMR magnetic stirrer was developed for the pharmaceutical industry and biotechnology to thoroughly mix sensitive products in a sterile and gentle way, and to make the FDA and GMP-conform documentation of the stirring process possible. Further applications can be found increasingly in industrial branches where sterile or toxic liquids are stirred e.g. in glass vessels. For this purpose, the devices have been designed without compromise for permanent use in the production process and work maintenance-free for years even under difficult environmental conditions. The integrated fault indicating system for the stirring staff combines the advantage of the magnetic drive with the safety of a mechanically coupled stirring unit: ••• Sterility, since no shafts are routed through the product space. ••• Universal use of a wide range of different container types made of non-magnetic materials, such as various stainless steels, plastics or glass. ••• Easy cleaning and sterilising of the stirrer staff, no complicated storage geometry as with impeller stirring units. CIP and SIP-friendly design. Sterile containers can be sterilised with stirring staff in the autoclave. ••• One magnetic stirring system can be used for several batching tanks, since the drive unit is not connected to the container. With mobile containers, for example, batching can be carried out in a different production area. ••• Powerful and centring magnetic drive field, so that distances of a few centimetres between the stirring unit and the magnetic staff can be realised. ••• Fault message when the magnetic force closure between drive and stirring staff breaks down, which can happen with magnetic stirrers on account of the system and leads to uncontrolled standstill of the stirring function despite rotating stirring unit. "Automatic stirring staff catch" for the automatic reestablishment of the stirring function. ••• Time sequence control for the linear speed reduction at filling stations for e.g. vaccines containing adjuvants in order to avoid foam forming when the filling level in the product container drops. ••• Clear documentation of the stirring process according to FDA and GMP guidelines through recording of speed curves and fault message voltage by means of a recorder.

Sterile can with centrally running 500 litre glass container with freewheeling stirring staff on the lifter tube. Teflon-coated special stirring staff.

R = 400mm

Dipl.-Ing. V. TEICHMANN Meß-Regel-Verfahrenstechnik D - 35094 Lahntal-Kernbach

Dipl.-Ing. V. TEICHMANNTEICHMANN Meß-Regel-Verfahrenstechnik Drehfeld - Durchmesser 200 mm für D - 35094 Lahntal-Kernbach Betrieb 2 - polige Rührstäbe, Länge 150 - 250 mm.

Drehfeld - Durchmesser 100 mm für BetriebBetrieb Integrierter Magnetstabsensor für die Störung 2 - polige Rührstäbe, Länge 80 - 150 mm. Störmeldung Rührstab / Antrieb. Rührstab

Integrierter Magnetstabsensor für die Störung

Störmeldung Rührstab / Antrieb Rührstab Beim Betrieb des Gerätes Warnung vor magnetischem Feld, sind die Hinweise gemäß

auch bei abgeschaltetem Gerät. der Beschilderung und Warnung vor magnetischem Feld, Beim Betrieb des Gerätes der Bedienungsanleitung sind die Hinweise gemäß Gefahrenhinweise beachten ! zu beachten !

auch bei abgeschaltetem Gerät. der Beschilderung und Gefahrenhinweise beachten ! der Bedienungsanleitung zu beachten !

Dipl.-Ing. V. TEICHMANN • Measurement, Control & Process Engineering • Am Bornacker 6 • D-35094 Lahntal-Kernbach Telephone: +49 (0) 6420 7666 Facsimile: +49 (0) 6420 7868 E-mail: [email protected] Device and functional description

2. Function Page 5

TMR magnetic stirrers produce a 2-pole permanently magnetic rotating field with a diameter of 100 mm (TMR-102-...) respectively 200 mm (TMR-202-...) . The magnetic field lines are bundled by special pole shoes and project almost vertically from the work surface. There is a magnetic staff in the product container that aligns itself in the drive field on account of the magnetic attractive force and is rotated synchronously by this field. This allows stirring unit and magnetic staff to rotate at the same speed in uninterrupted operation. In contrast to the directly driven stirring unit, however, the forced closure between the drive and stirring staff can break off with the magnetic stirrer, so that the stirring process is interrupted despite the fact that the stirring unit is still rotating and thus producing a speed indication . This operational problem cannot be detected without visual inspection and requires the use of supervisory personnel as well as containers with optical control possibilities. Since the stirring staff cannot synchronise itself automatically after a break in connection, the stirring process remains interrupted until the speed has been reduced manually. In sensitive areas of chemical-pharmaceutical laboratory and production technology, automatic monitoring and documentation of the stirring function is an absolute must. For this purpose, the units are equipped with a complex fault indicating and self-monitoring system, whereby the magnetic staff sensor necessary for this has been able to be integrated fully in the drive housing so that no sensors are necessary in or on the container. With all permissible stirring staffs, a break in forced closure, a lack of or blocked stirring staff as well as a tumbling stirring staff due to damage or wear are safely detected. An "automatic catch" tries to catch the stirring staff automatically by reducing the speed in the event of a problem, so that the stirring process is only interrupted for a short time. In addition, internal drive problems, e.g. motor switching off due to excess temperature, are also detected. A general distinction must be made between two variants of stirring staffs (see sketches on page 3): ••• Teflon-coated stirring staffs freewheeling on the container base and ••• Stainless steel-encapsulated stirring staffs that are centred with Teflon or ceramic bearing on a pin in the container base or are fixed to the lifter tube. Freewheeling Teflon-coated stirring staffs are particularly advantageous since they can remain in the container during cleaning and sterilisation and no bearing spots need monitoring. All stirring staffs can be adapted optimally to conditions in terms of both size and arrangement, so that gentle product mixing can take place even at low speeds.

Supervision work plate stirring unit TMR-102-S Functional principle of TMR magnetic stirrer

N S

N S m 0 Magnetic staff 0 S sensor N

100mm Rotating field

400mm

2. Function Page 6

The device is made up of a torsion-resistant, highly durable aluminium profile frame structure and a fixed axle as additional central support for the work surface, so that even heavy containers can be set up on it (150 kg with evenly distributed load) . The housing has the following dimensions: Workplate : 405 x 405 mm Device height : 170 mm + 25 … 60 mm height of base adjustable Weight : ca. 19 kg Protecting rating : IP 43 (special version without ventilation slits IP 54) . The workplate is made of brush-finished special steel, material no. 1.4571. Paneling is made of patterned sheet metal „5 WL“, material no. 1.4301. The ball-bearing stirring unit is driven by a special asynchronous squirrel-cage motor with a high torque. Digital speed recording and maintenance-free, highly efficient flat belt gear guarantee operational safety under tough environmental conditions. A built-in external fan for the interior switches on automatically under extreme load in case the heat dissipation via the metal housing is no longer sufficient. The air intake and discharge openings are on the bottom of the device and protected by special coarse filters so that no drops of water can penetrate the inside. In addition, a reversible excess temperature protection feature is installed for the motor, including fault message. Thanks to special permanent magnets with pole shoes, an extremely powerful and centring drive field is generated. The built-in highly sensitive magnetic staff sensor can detect a problem with the stirring staff within the following functional areas: Stirring staff type Dimensions with collar Distance stirring staff - Work surface B 10070 Ø 10 x 70 mm 0 – 20 mm B 16100 Ø 16 x 100 mm 0 – 30 mm B 25110 Ø 25 x 110 mm 0 – 40 mm B 25155 Ø 25 x 155 mm 0 – 50 mm B 34150 Ø 34 x 150 mm 0 – 60 mm

The magnetic stirring unit can be used as a table-top device or as a built-in version under batching tanks, production lines, worktables, non-magnetic water baths etc.

4. Control unit MAGNETRONIC DSZ-5010 Page 7

The electronics are housed in a stainless steel housing with fold-out carrying handles, connection panel on the rear and cable bracket. The built-in speed control works in the 25 - 500 rpm range and keeps the preselected reference value constant in the face of fluctuations in mains voltage, changes in load and temperature influences. The current speed of the stirring unit can be read off on a 3-digit LED display and is recorded parallel to this on channel 2 of the recorder. To prevent a premature break in forced closure between the stirring unit and magnetic staff in the acceleration phase, the run-up time can be preselected infinitely between 0,1 - 5 minutes. The built-in "fault indicating system for the stirring staff" is used for comprehensive monitoring of the stirring function. A fault message is given in the event of • Break in forced closure between the stirring unit and magnetic staff. Possible causes are speed being selected too high, run-up time being too short, turbulence in the liquid or excessive distance between the stirrer and the magnetic staff. • Stirring staff missing or blocked. • Wobbling stirring staff due to damage, poor magnetisation or wear. • Internal problem, e.g. excess temperature, mechanical or electrical drive defect etc. The fault message is given through a flashing LED display and a warning buzzer with adjustable volume. In addition, an alarm relay is switched with 2 potential-free changeover contacts that are accessible via the connection panel on the back: Contact load AC 250 V / 5 A. When the "automatic stirring staff catch" is switched on (green LED display on the control panel), the speed of the magnetic stirring unit is automatically reduced to 25 rpm in the event of a problem, so that the stirring staff is pulled back into the drive field. When the forced closure has been made again, the stirring staff "caught", the drive unit runs up again to the originally set speed during the set run-up time. This means the stirring process was only interrupted briefly. The fault message remains activated until it is acknowledged by means of the built-in key button. (Automatic reset after an adjustable delay can be preset on the electronic plug-in card.) In the "OFF" switch position, there is no reduction in speed after a fault message, so that the stirring staff is not automatically pulled back into the drive field at higher speeds and the stirring process remains interrupted despite the stirring unit rotating. The fault message remains active in this case. A yellow LED display flashes as a warning in this operating mode. The "automatic stirring staff catch" should only be switched off in exceptional cases if, for example, work has to take place with unsuitable stirring staffs under visual inspection.

4. Control unit MAGNETRONIC DSZ-5010 Page 8

Within the circuit, a fault indication voltage is generated that is proportional to the forced closure between the stirring unit and magnetic staff and is recorded on channel 1 of the built-in recorder. At the same time, a 12-segment bar display serves the visual evaluation of force transmission and / or as an adjustment aid for aligning the stirring unit under one container. Below 50 % of the indicated range the stirring process is interrupted: Fault message. The higher the amplitude is above 50 %, the better the magnetic coupling. This way, an imminent drive interruption can be predicted and the maximum safe speed can be determined for a certain stirring process.

Frictional connection 90 % 10 30 50 70 Force closure between stirring unit and magnetic staff is torn off, the stirring staff is blocked within the rotating field, e.g. with central stirring staffs, excess motor temperature or device fault. interrupted critical - strong Malfunction Operation 50 %

No stirring staff in the container, a freewheeling stirring staff is blocked outside the revolving field, or the automatic stirring staff catch is switched off.

Uninterrupted stirring process but poor force closure: Only low power capacities can be transferred. Stirring staff is too small or there is too much space between the magnetic stirrer and the stirring staff.

Uninterrupted stirring process, optimum force closure between magnetic stirrer and stirring staff. Full utilization of power capacity possible.

The built-in time lapse control has been developed especially for filling stations in order to avoid air pockets caused by surface turbulence when the filling level is falling, and thus foam formation. For this purpose, the speed is reduced linearly and automatically down to 50 rpm within an adjustable time range (filling time) from 10 minutes to 10 hours. Here a computer stores the selected initial speed and then determines the required speed reduction per minute from the time entered. The remaining time till the end of the lowest speed is displayed digitally in hours / minutes. Time lapse and speed reduction can be interrupted using the break switch. The time lapse control is switched on using the START pushbutton and then controls the speed curve.

The built-in two-channel recorder serves for documentation of the speed curve and the fault indication voltage. The recorder has its own mains switch behind the front door that should always remain switched on. For documentation of the stirring process in accordance with FDA and GMP guidelines it is essential to record the speed curve on one channel and the fault indication voltage parallel to this on a second channel, since this is the only way a fault during the stirring process can be recognised absolutely certainly. Since the speed is not automatically reduced when there is a break in forced closure between the stirring unit and magnetic staff when the automatic stirring staff catch is switched off, the stirring process grinds to a halt despite the stirring unit continuing to rotate and thus despite a speed indication, since the stirring staff is no longer automatically synchronised. As a result, this fault cannot be detected on the basis of the recorded speed, but rather only on the basis of the sensor voltage of the fault indication system recorded parallel to this, which in the case described falls to under 50 %. A detailed description of the recorder documentation can be found on the following pages.

5. Recorder printout as an example for an FDA -conform Page 9 documentation of a stirring process with faults.

G) The speed is reduced to 50 rpm in order to prevent air entering the product when the 0 20 40 % 60 80 100 filling level is low. This makes pulsations of the fault indication voltage increase, since the stirring staff 0 100 200 rpm 300 400 500 makes more and more wobbling movements. F) The selected reference speed happens to be near the resonance speed of the stirring staff used, so that rotating vibrations occur 14:00 sporadically. These lead to fluctuations in the fault indication voltage, but are not relevant for the stirring process. 13:00 E) The "automatic stirring staff catch" is switched on again and a lower reference speed of 200 rpm is chosen. This automatically reduces the stirring unit 12:00 speed to 25 rpm, so that the stirring staff is synchronised and the stirring process is continued.

11:00 D) The automatic stirring staff catch is switched off for test purposes and the reference speed increased to 350 rpm. At about 320 rpm the forced closure 10:00 between stirring staff and drive is broken. This makes the stirring staff get "out of step" and the stirring effect stops: Fault message 3 . When the automatic stirring staff catch is 009:00 20 40 60 80 100 switched off, the stirring unit runs up to its reference speed, however, so that it is no longer synchronised and the stirring effect remains interrupted. 08:00 This means that the stirring process fault cannot be detected on the basis of the speed curve, but rather only on the basis of the recording of the fault indication voltage, 1 Channel 1: Force closure stirring unit ‹–› magnetic staff which remains under 50 %. For this reason, the speed and the fault 2 Channel 2: Speed stirring unit indication voltage must both be recorded for a definite documentation of the stirring process. C) Another batching tank with stirring staff is added, so that the fault indication voltage increases to more than 50 % and the magnetic stirrer runs up to the preselected reference value of 200 rpm during the set run-up time. Device data and setting values B) The magnetic stirring unit is pushed under the container so that the speed block is Product container : Batching tank 150 litre automatically cancelled and the stirring unit runs up to catch speed of 25 rpm: Teflon stirring staff : Ø 25 x 110 mm, freewheeling Fault indication volt. 19 % = Fault message 2 . Speed preselection : 250, 350, 200 and 50 rpm Fault diagnosis: No stirring staff in the tank. Run-up time : 3 minutes Fault message 1 : Speed block, since the magnetic stirrer A) Mains switch „ON“. system has not been pushed under the Automatic stirring staff catch „ON“. transport carriage of the batching tank yet. The speed block (special feature) triggers, Fault message 2 : Missing stirring staff in the container. since the carriage with the magnetic stirrer is not placed under the container yet: Fault message 3 : Excessive speed and the automatic stirring staff catch” Fault indication volt. < 1 % = Fault message 1. is switched off. Fault diagnosis: The stirrer does not move.

6. Recorder printout as an example for a program sequence Page 10 of time lapse control at a filling station.

0 20 40 % 60 80 100

0 100 200rpm 300 400 500 H) Pulsations of fault indication voltage increase at low speeds for reasons inherent in the system, but this is not important for the monitoring function. 14:00 G) 14°° h: End of filling process. The minimum speed of 50 rpm is reached 13:00 after 5 hours of filling time and 1 hour of break time.

F) Slight fluctuations in the fault indication 12:00 voltage are normal and are caused by rotary oscillations of the stirring staff at certain resonance speeds.

11:00 E) 11 30 h: The break circuit is cancelled and the filling process continued. D) 10 30 h: The break circuit has been activated. 10:00 This makes the speed "freeze" at the current value and stops the "time left" display. C) The container is moved by mistake so that the bearing pin of the stirring staff is no 009:00 20 40 60 80 100 longer aligned to the axle of the stirring unit axle and the forced closure breaks: Fault message. 08:00 The automatic stirring staff catch reduces speed to 25 rpm until the container is aligned and the stirring staff has been 1 Channel 1: Force closure stirring unit ‹–› magnetic staff caught again. Then the speed is increased automatically 2 Channel 2: Speed stirring unit during the set run-up time to the original value so that the stirring process was only interrupted briefly. B) 8°° h: The stack tank is set onto the auxiliary frame with the stirring unit and the time lapse control is started up: Device data and setting values The stirring unit runs up to its reference value of 250 rpm during the set run-up time. Product container : Stack tank 250 litre After this, linear speed reduction begins Stainless steel stirring staff : Ø 30 x 160 mm according to the automatic program. with ceramic bearing Mains switch „ON“. Initial speed : 250 rpm A) Automatic stirring staff catch „ON“. Final speed : 50 rpm The stirring unit runs without container Run-up time : 3 minutes and thus without stirring staff to catch Filling time = : 5 : 00 hours speed 25 rpm Time specification Fault indication volt. 20 % = Fault message. Break time : 1 hour Fault : Caused by displacement of the stack tank

7. Flow diagram of all alarms with the respective reactions. Page 11

Connect mains cable !

Fault indication relay dropped out Mains switch NO = switched on ? Electric fault message.

YES

Acoustic Smooth operation. and optical NO Stirring unit running at reference speed. fault message Fault indication relay is activated. active ? Bar display for forced closure > 50 %.

YES Excess motor temperature, stirring unit at a standstill. Fault indication relay dropped out. Fault indicator lamp flashing in acknowledge button. NO Speed n > 0 rpm ? Warning buzzer is active. Bar display for forced closure < 10 %. All segments dark. YES

Speed n > 25 rpm. Automatic stirring staff catch is switched off (Exception). IMPORTANT NOTE ! Speed NO Yellow indicator lamp flashing. Check ventilation openings n = 25 rpm ? Stirring staff cannot be on the base of the magnetic synchronised automatically. stirring unit for free access ! YES

Automatic stirring staff catch IMPORTANT NOTE ! is switched on. Switch on automatic stirring Normal operation is indicated staff catch if possible ! by a green indicator lamp. Motor cooled NO down to operating temperature ?

YES FAULT MESSAGE STIRRING STAFF Fault indication relay dropped out. Fault indicator lamp flashing Stirring unit starts gently. in acknowledge button. Warning buzzer is active. Bar display for forced closure < 50 %.

ELIMINATE THE PROBLEM Rocker switch on the fault WITH THE STIRRING STAFF WITH message board SR-CONTROL-4H THE AID OF THE FORCED CLOSURE is in the switch position BAR DISPLAY, SEE PAGE 6. "fault memory ON".

The stirring unit runs up to reference speed. NO Forced closure bar display Fault indicator lamp in acknowledge > 50 % ? button continues to flash. Warning buzzer remains active. YES Fault indication relay remains dropped out.

Automatic NO acknowledgement ? PRESS THE ACKNOWLEDGEMENT YES BUTTON !

Rocker switch on the fault message board SR-CONTROL-4H is in the switch position "fault memory OFF". Acknowledgement NO given ?

Automatic transition YES to smooth operation

Stirring unit runs up to reference speed. Smooth operation Fault indicator lamp goes off. Fault indicator lamp goes off Warning buzzer switches off. Warning buzzer switches off. Fault indication relay is activated. Fault indication relay is activated.

8. Hazard warning Page 12

HAZARD WARNING ! Always heed the "safety instructions" before use !

WARNING of magnetic field, even with the stirring unit switched off ! Do not place any sensitive devices e.g. watches/clocks, monitors, measuring instruments etc. near or on the magnetic stirrer !

People with pacemakers or other sensitive life-sustaining devices have to keep at an appropriate safe distance ! Ask your doctor or device manufacturer whether functional problems can be excluded !

Do not place any magnetic objects such as screwdrivers on the work surface of the magnetic stirrer ! T H E P A R T S C A N B E F L U N G O F F ! D A N G E R O F I N J U R Y !

Only operate the stirring staffs in closed containers, do not leave open !

BE CAREFUL WITH GLASS VESSELS: DANGER OF BREAKING ! Do not let the stirring staffs fall through the bottle neck when inserting them into the vessel ! Choose the speed so low that the stirring staff cannot be flung out of the rotating field and/or use a correspondingly small and lightweight stirring staff.

Centrally running stirring staffs (bearing pin in the base of the vessel) have to be aligned centrally to the work surface of the magnetic stirrer ! Once set up, containers must be secured against displacement through respective retention fittings ! If the stirring staff's bearing pin is no longer aligned to the stirring unit axle, dangerous malfunctions can occur with the stirring staff fault indication system so that a break in forced closure is no longer detected reliably and the stirring process comes to an uncontrolled halt! Maximum permissible alignment fault: ± 20 mm

In cases of damage, particularly to the mains or connection cable to the stirring unit, the unit must be switched off immediately and disconnected from the mains supply. Otherwise danger of F A T A L I N J U R Y through electric shock !

9. Model selection list Page 13

TMR Magnetic Stirrer Speed control Normal speed range : 25 ... 500 rpm Slow speed range for : 25 ... 300 rpm large containers > 500 litres Start-up time adjustable : 6 s ... 5 min Speed indicator 3 digit : LED - display

Fault indicating system stirring staff Bar display for forced closure. Automatic stirring staff catch. Visual and acoustic fault signal. Outputs fault signal relay, 2 changeover contacts.

Worktop stirring unit TMR-102-.. : 405 x 405 mm (width x depth) TMR-102-..V : 330 x 460 mm (width x depth) Narrow version for limited installation conditions TMR-202-.. : 455 x 455 mm (width x depth)

Compact Magnetic Stirrer System Magnetic Stirrer Table-top device with workplate. Separate control and magnetic drive units. Inclined control panel. Flexible selection of components allows superior adjustment to Integrated electronic boards. varying applications. Recorder outputs for speed and Control units with built-in stirring staff fault signal voltage recorder available. for a clear documentation of the stirring process according to Control units with integrated time FDA and GMP guidelines. lapse control for the linear speed reduction at filling stations.

Stirring capacity Control units Magnetic drive units for volumes up to 300 liters 200 ...1000 liters Device table top / wall mounted up to 300 liters 200 ...1000 liters with lockable front door. Magnetic Magnetic Magnetic Magnetic drive field: drive field: Plastic or stainless steel housing. drive field: drive field: ø 100 mm ø 200 mm Suitable for all magnetic drive units. ø 100 mm ø 200 mm

Magnetic Magnetic MAGNETRONIC DS-50 Magnetic Magnetic stirrer stirrer drive unit drive unit MAGNETRONIC DS-30 TMR-102-SK TMR-202-SK TMR-102-S TMR-202-S Recorder outputs. TMR-102-SKV TMR-202-SKD3 TMR-102-SV TMR-202-SD3 Internal 19"-module rack. External dimensions plastic housing: approx. 435 x 325 x 170 mm (w x h x d)

Magnetic Magnetic MAGNETRONIC DSS-50 stirrer for stirrer for remote control remote control MAGNETRONIC DSS-30 TMR-102-FSK TMR-202-FSK Built-in recorder. TMR-102-FSKV TMR-202-FSKD3 Internal 19"-module rack. External dim. stainless steel housing: approx. 550 x 250 x 300 mm (w x h x d)

MAGNETRONIC DSZ-5010 MAGNETRONIC DSZ-3010 Built-in recorder. Time lapse control for the linear speed reduction up to 10 hours, e.g. at filling stations. External dim. stainless steel housing: approx. 500 x 500 x 300 mm (w x h x d)

10. Compact magnetic stirrer with fault indicating system for the stirring staff Page 14

Compact table-top units with built-in electronics and slanted front plate for comfortable operation. Also available in a slim version and remote-control version. Special features: • Torsion-proof, heavy-load capacity structural frame made of aluminium profiles with diagonal bracing under the work plate. Work plate with ground finish, special steel no. 1.4571. Paneling, patterned sheet metal, special steel no. 1.4301. • Easy-to-service construction. • Operating and display elements in protective class IP 65. Type of housing protection: IP 43 (ventilation openings at the device base). • A fixed-position stirring mandrel serves as additional central support for the work plate, so that even heavy containers can be set on it: up to approx. 150 kg if the load is uniformly distributed. • Special maintenance-free asynchronous squirrel-cage motor with a high starting torque and digital speed recording. • Maintenance-free, highly efficient flat belt gear. • Ambient temperature 0 - 50 °C. • Extremely powerful and centring drive field, generated by special permanent magnets with pole shoes. • Speed control with a bright 3-digit LED display for the current speed of the stirring unit. • Fault indicating system for monitoring the stirring function with the following guideline values for the functional area:

Stirring stuff Stirring stuff Distance stirring staff - Work surface Distance stirring staff - Work surface Type Size with collar TMR-102-SK TMR-202-SK B 10070 Ø 10 x 70 mm 0 - 20 mm Not suitable B 16100 Ø 16 x 100 mm 0 - 30 mm Not suitable B 25110 Ø 25 x 110 mm 0 - 40 mm Not suitable B 25155 Ø 25 x 155 mm 0 - 50 mm 0 - 40 mm B 34150 Ø 34 x 150 mm 0 - 60 mm 0 - 50 mm K 34/2 40 x 40 x 210 mm Not suitable 0 - 60 mm B 6060250 60 x 60 x 250 mm Not suitable 0 - 70 mm

• 12-segment bar display serves the visual evaluation of force transmission between the stirring unit and magnetic staff. • Outputs 0 - 10 V for speed and force transmission permit documentation of the stirring process according to FDA and GMP guidelines.

Art. no. Magnetic stirrer Mains voltage / Dimensions Weight Drive field Speed Recommended Type power max. w x d x h (mm) 2-pole (rpm) stirring volume TMR-102-SK TMR-102-SK 230 V / 290 VA 405 x 450 x 190 21 kg 100 mm 25 - 500 Up to 300 litre TMR-202-SK TMR-202-SK 230 V / 440 VA 455 x 510 x 230 37 kg 200 mm 25 - 500 Up to 500 litre TMR-202-SKD3 TMR-202-SKD3 230 V / 440 VA 455 x 510 x 230 37 kg 200 mm 25 - 300 Up to 1000 litre Special versions on request Ambient temperature: 0 - 50 °C Type of protection: IP 43

Options IP54 – Protective class IP 54 without ventilation slots with reduced output or switch-on duration. KAL – Comprehensive calibration documents also cover the functional qualification.

11. System magnetic stirrer with fault indicating system for the stirring staff Page 15

With magnetic stirrer systems, stirrer and control unit are separate, so that the individual components can be optimally adapted to the application case and the special requirements. See the device and function description, pages 3 - 10, for details of function and technical equipment. Control units with built-in recorders are available for the accompanying documentation in accordance with FDA and GMP guidelines. Optionally, a time lapse control can be installed to linearly reduce the speed at fill stations. This prevents air entering the product through turbulence on the surface and thus foam formation as the filling level drops. The magnetic stirrer system can be delivered mounted on an undercarriage which is pushed under special transport trolleys for the batching tanks. A distance sensor only releases speed regulation when the trolley with the magnetic stirring system has been pushed into its final position. This guarantees that freewheeling stirring staffs do not strike against the tank walls causing damage.

Art. no. Magnetic stirrer Mains voltage / Dimensions Weight Drive field Speed Recommended Type power max. w x d x h (mm) 2-pole (rpm ) stirring volume TMR-102-S TMR-102-S 230 V / 260 VA 405 x 405 x 190 19 kg 100 mm 25 - 500 Up to 300 litre TMR-202-S TMR-202-S 230 V / 410 VA 455 x 455 x 230 33 kg 200 mm 25 - 500 Up to 500 litre TMR-202-SD3 TMR-202-SD3 230 V / 410 VA 455 x 455 x 230 33 kg 200 mm 25 - 300 Up to 1000 litre Special versions on request Ambient temperature: 0 - 50 °C Type of protection: IP 43

Art. no. Control unit Mains voltage / Dimensions Weight Signal outputs respectively Time sequ. MAGNETRONIC power max. w x d x h (mm) recorder / data logger control DS-50 DS-50 230 V / 25 VA 435 x 325 x 170 8,5 kg Speed / force transmission No DSS-50 DSS-50 230 V / 75 VA 550 x 300 x 275 18 kg Recorder / data logger No DSZ-5010 DSZ-5010 230 V / 100 VA 500 x 300 x 500 31 kg Recorder / data logger Yes Special versions on request Ambient temperature: 0 - 45 °C Type of protection: IP 65

Options - 30 – For control units with a speed range of 25 - 300 rpm, e.g. DS-30, DSS-30, DSZ-3010. IP54 – Stirrer protective class IP 54 without ventilation slots with reduced output or switch-on duration. KAL – Comprehensive calibration documents also cover the functional qualification. ETH – Ethernet interface for data communication, only with control unit DSS-30/50 and DSZ-3010/5010.

12. Stainless steel carriages for TMR magnetic stirrer systems Page 16

Undercarriages for TMR magnetic stirrer systems • Base frame made of rectangular tubes with base plate welded on. • 4 casters, 2 x with full brake. • Wheel treads made of polyurethane (red). • Cover for magnetic stirrer: metal hood screwed in place, with warning signs and type plate. • Angled drawbar as receptacle for the electronic unit and holder for the mains supply cable.

• Material 1.4301, electropolished, R A < 1 µ. • Type plate electrolytically signed. • External dimensions with mounted magnetic stirring system, consisting of a control unit DSS-50 VA with a stirring device of Type TMR-102-S: 1070 x 550 x 1205 mm (width x depth x height).

Transport carts for containers • Base frame made of rectangular tubes with feet welded on. • Cover plate made of 3 mm brushed stainless steel sheet.

• Material 1.4301, electropolished, R A < 1 µ. • 4 casters, 2 x with full brake. • Wheel treads made of polyurethane (red). • Integrated guide rails made of PE for guiding the undercarriage with the magnetic stirrer system. • Brackets on the cover plate made of PE 1000 or stainless steel for fixing the foot rim of the product tank in place. • Type plate electrolytically signed on right foot. • Warning signs on the corners of the cover plate and a pictogram in the centre showing the correct tank position.

Equipment combination for container weight up to 170 kg

Art. no. Undercarriage TUW Dimensions Weight Load-bearing Working height Foot rim Transport cart TTW w x d x h (mm) capacity support surface container TUW-DSS11 TUW-DSS11 1070 x 550 x 967 37 kg 126 kg 292 mm TTW-620/420 TTW-620/420 617 x 612 x 333 29 kg 170 kg 303 mm Ø 420 mm Other versions on request

Equipment combination for container weight up to 257 kg

Art. no. Undercarriage TUW Dimensions Weight Load-bearing Working height Foot rim Transport cart TTW w x d x h (mm) capacity support surface container TUW-DSS12 TUW-DSS12 1070 x 550 x 987 37 kg 226 kg 312 mm TTW-727/565 TTW-727/565 727 x 700 x 352 42,5 kg 257 kg 322 mm Ø 565 mm Other versions on request

13. Control unit DSS-50 VA mounted on an undercarriage TUW-DSS11 Page 17

Display and operating panel

Connection panel on the rear

14. Glass vessel 50 litre on a mobile magnetic stirrer system Page 18

15. Final-Bulk container 150 litre, made by BINDER, on a transport cart TTW-727/565 Page 19

About the company Page 20

We have been working in the development and production of high-quality components for chemical and pharmaceutical laboratory and production technology for more than 35 years. The quality, durability and ease of service of our products are our top priority. In addition to the magnetic stirrers / products shown here, our range includes accessories for freeze-drying and customised solutions: • Measuring equipment for determining eutectic. • Injection vials with built-in temperature and conductivity sensors. • Aluminium frame transport cases for vials, glass syringes etc. • Temperature sensors NiCr-Ni and Pt100. • Pt100 temperature sensors with hose connectors for fluids. • Vacuum-tight measuring line passages etc. These are presented in a separate brochure „Measuring units for conductivity, temperature probes, vials and combined sensors for temperature / conductivity“

Thanks to our long years of experience, we can also offer you new product development according to your specific requirements; these have the same high level of quality and workmanship as our series products. Please contact us!

Copyright note All the logos, illustrations, drawings and texts as well as the graphic design of our brochure documents are protected by copyright. Reproduction, copying and translation - even in part - are only possible if permission has been granted in writing. The illustrations can deviate from current products. We reserve the right to make changes without prior notice.

Address Dipl.-Ing. V. TEICHMANN Measurement, Control and Process Engineering Am Bornacker 6 D - 35094 Lahntal - Kernbach

Owner Dipl.-Ing. Volker Teichmann

VAT ID number DE113339654

Contact Telephone : +49 (0) 6420 7666 Facsimile : +49 (0) 6420 7868 E-mail : [email protected] Homepage : www.pharmasupplier.de