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// TUMOR MARKERS
Pituitary gland HGH, ACTH, Prolactin
Parathyroid gland Breast CA 15-3, PTH CEA
SCC, Neck / Head region Stomach CA 72-4, CEA (CEA)
Calcitonin, Thyroid Pancreas Thyreo- CA 19-9 globulin
Colon / Rectum SCC, Oesophagus CEA, CEA CA 19-9
NSE, Cyfra 21-1, Kidney Lung / Bronchial M2-PK, ProGRP, TPA SCC, CEA
Liver Adrenal cortex DHEA-S, AFP Cortisol, Aldoste- rone
Pheochromocytoma / Meta- CA 19-9, Gall bladder / Bile duct nephrines CEA Neuroblastoma (Plasma), *
Serotonin, Carcinoid Ovarian CA 12-5, 5-Hydroxy- CA 72-4, acetic acid CASA (urine)
Cyfra21, Uterus TPA, Bladder CA 125, NMP22 CA 19-9 (urine)
Cervix PSA Prostate SCC, PCA3 CEA
Para- AFP, Lymphatic proteins, HCG, Testicular Bence-Jones Placenta-AP, myeloid system Proteins, LDH #
Bone Ostase, Protein Skin / Melanoma Desoxy- S-100 pyridinoline (urine)
* Catecholamines (urine), vanillylmandelic acid, homovanillic acid, NSE # Thymidine kinase, ß2-Microglobulin BIOSCIENTIA | Tumor Markers | Page 2/2
TUMOR TURMOR MARKER OR TYPICAL METABOLITE TUMOR MARKER 2ND CHOICE
adrenal cortex DHEA-S, Cortisol, Aldosterone
bile duct / gall bladder CA 19-9, CEA
bladder cancer Cyfra 21-1, TPA, NMP22 in urine
breast cancer CEA, CA 15-3 HER-2 / new (serum, tissue) uPA / PAI-1 (tissue) ER and PR (tissue) bronchial carcinoma oat cell carcinoma NSE, ProGRP ACTH, Calcitonin, Cyfra 21-1 squamous cell carcinoma SCC, Cyfra 21-1, CEA adenocarcinoma Cyfra 21-1, CEA TPA magnocellular carcinoma Cyfra 21-1, CEA carcinoid Serotonin, 5-hydroxyindolacetic acid in urine
cervix cancer SCC, CEA
chorio carcinoma ß-hCG (Cystic mole) colo-rectal carcinoma CEA CA 19-9
gastric carcinoma CA 72-4 CEA, CA 19-9, CA 50
hypophyseal tumor HGH, ACTH, Prolactin FSH, LH, TSH
lymphatic and Paraproteins, ß2-Microglobulin, myeloid leukemias Thymidine kinase, Neopterin malignant tumors in the SCC, CEA Cyfra 21-1 head and neck region melanoma Protein S-100
nephrocarcinoma M2-PK, TPA CEA (hypernephroma) neuroendocrine tumor NSE, Chromogranin A (APUD cell tumor) oesophageal carcinoma SCC, CEA
osteosarcoma, Ostase, bone metastases (Desoxy-)Pyridinolin in urine ovarian cancer epithelial CA 125, CASA mucin CA 125, CA 72-4 pancreatic cancer CA 19-9 CA 125, CA 50, CEA
pheochromocytoma / Metanephrines in plasma, catecholamines in urine and plasma, paraganglioma Metanephrines in urine vanillylmandelic acid in urine, Chromogranin A prostatic cancer PSA, free PSA, PCA3 in urine
testicular cancer germinal tumor AFP, ß-hCG, LDH seminoma Placenta-AP, AFP, ß-hCG, LDH NSE thyroid cancer papillary, follicular Thyreoglobulin medullary (C cell carcinoma) Calcitonin, CEA uterus carcinoma CA 125, CA 19-9 TPA, CEA
Zollinger-Ellison-syndrome Gastrin (Gastrinoma) BR1051 11/18 BR1051