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Personalized Medicine Conference Program 8th Annual Personalized Medicine Conference Program November 28-29, 2012 Joseph B. Martin Conference Center at Harvard Medical School, Boston Highlights Of Past Conferences 2 | 8TH ANNUAL PERSONALIZED MEDICINE CONFERENCE INTRODUCTION November 28, 2012 Dear Colleague, SUPPORTERS Welcome to the 2012 Personalized Medicine Conference. We and the other members of the Conference Organizing Committee, whose names you will see on the last page of this program, are pleased to offer this eighth annual gathering co-hosted by Partners HealthCare, Harvard Medical School and Harvard Business School. We offer our profound thanks to the speakers, panelists, our generous Conference Supporters and the staff for all that they do to make this PROGRAM meeting meaningful and worthwhile. The Personalized Medicine Coalition (PMC) has been actively involved in this Conference since its inception in 2005 and that relationship continues to play a key role in our annual meeting. The PMC’s perspectives and depth of understanding of the issues surrounding SPEAKERS personalized medicine have added greatly to the considerations about the conference program and content. It is especially pleasing that the PMC has chosen this venue to present its annual Award for Leadership in Personalized Medicine that this year will be received by Randall Johnson. The goal of medicine is to maintain health, prevent disease and to provide the most effective ABOUT US treatment for all patients. Our Conference started with the belief that Personalized Medicine is a way to accomplish all of these goals. Extraordinary progress is being made in genetic and genomic understanding about health and disease, about the advances that have led to dramatically lower costs of sequencing and other technologies, about the commitment ORGANIZING of pharmaceutical companies to using the principles of personalized medicine in drug COMMITTEE development, about the evermore sophisticated capabilities of molecular diagnostics and about the increasing implementation of advanced IT applications in integrating genetic and genomic information into the clinical decision making of providers. Much remains to be done, however. The purpose of this annual Personalized Medicine Conference, as it always has been, is to continue to bring together the best minds across a broad spectrum of stakeholders to consider the opportunities and challenges, and to understand what the next steps should be, to reach the fullest implementation of personalized medicine. We hope you will find this meeting engaging and stimulating and that you will offer your own wisdom and perspective to the conversations. It should be an opportunity for you to renew friendships, expand acquaintances and meet new people whose knowledge will enhance your own understanding of personalized medicine. Welcome, again, to what we trust you will find a productive and enjoyable meeting. Sincerely, Scott T. Weiss, M.D., M.S. Raju Kucherlapati, Ph.D. Scientific Director Paul C. Cabot Professor of Genetics and Partners HealthCare Center for Professor of Medicine, Harvard Medical School; Personalized Genetic Medicine Chair, Conference Organizing Committee Professor of Medicine, Harvard Medical School 8TH ANNUAL PERSONALIZED MEDICINE CONFERENCE | 3 a thank you to our supporters This conference is organized by the Partners HealthCare Center for Personalized Genetic Medicine and Harvard Business School in collaboration with the Personalized Medicine Coalition. It is made possible by the generous support of our supporters. Signature Gold Silver 4 | 8TH ANNUAL PERSONALIZED MEDICINE CONFERENCE Bronze INTRODUCTION SUPPORTERS PROGRAM SPEAKERS Contributing ABOUT US ORGANIZING COMMITTEE 8TH ANNUAL PERSONALIZED MEDICINE CONFERENCE | 5 Program Wednesday, November 28, 2012 8:00 a.m. Welcome Raju Kucherlapati, Ph.D. Paul C. Cabot Professor of Genetics, Professor of Medicine, Harvard Medical School Scott Weiss, M.D., M.S. Scientific Director, Partners HealthCare Center for Personalized Genetic Medicine; Associate Director, Channing Laboratory; Professor of Medicine, Harvard Medical School Jeffrey Flier, M.D. Dean, Harvard Medical School Introducer: Jeffrey Leerink Chair and CEO, Leerink Swann LLC 8:30 a.m. Impact of Genomic Moderator: Stephen Eck, M.D., Ph.D. Sequencing on Health Vice President, Global Head of Medical Oncology Sciences, Astellas Pharma Global Development, Inc. Human genome sequencing promises to be an Joe Beery important tool in assessing Senior Vice President & Chief Information Officer, Life Technologies risk, diagnosing disease and stratifying patient John Lauerman populations for targeted Reporter-at-Large, Bloomberg News therapy. The panelists will D. Holmes Morton, M.D. describe some personal Clinic Director, The Clinic for Special Children experiences of receiving sequence information Michael Snyder, Ph.D. and talk about how this Stanford Ascherman Professor and Chair of Genetics; Director, Center rapidly growing technology of Genomics and Personalized Medicine, Stanford University School of is transforming medical Medicine practice. 9:45 a.m. Perspectives From Speakers To Be Announced Professional Organizations 10:15 a.m. Networking Break 11:00 a.m. Genetic Basis for Drug Moderator: Hakan Sakul, Ph.D. Development Executive Director, Head of Diagnostics, Worldwide R&D, Clinical Research and Precision Medicine, Pfizer, Inc. Many drug developers are beginning to successfully Jeffrey Leiden, M.D., Ph.D. use genetic information President, CEO and Chairman and genetic markers Vertex Pharmaceuticals in drug development. This panel will provide Michael Streit, M.D., M.B.A. perspectives from three Executive Director, GlaxoSmithKline-Oncology different companies on George D. Yancopoulos, M.D., Ph.D., how they have used President, Research Laboratories and Chief Scientific Officer, Regeneron and are using genetic Pharmaceuticals information in successful drug development. 6 | 8TH ANNUAL PERSONALIZED MEDICINE CONFERENCE INTRODUCTION 12:00 Presentation of Award Recipient: Randall Scott, Ph. D. NOON Personalized Medicine Founder and Director, Genomic Health, CEO, InVitae Corp. Coalition’s 8th Annual Award for Leadership in Introducer: Edward Abrahams, Ph.D. Personalized Medicine President, Personalized Medicine Coalition SUPPORTERS Presenter: D. Stafford O’Kelley Chairman of the Board, Personalized Medicine Coalition 12:30 p.m. Networking Luncheon Open Seating 1:45 p.m. Business Models for Use of Ger Brophy, Ph.D. PROGRAM Genetic Information General Manager, New Product Development Medical Diagnostics The discussion should GE Healthcare highlight new business opportunities for large Kris Joshi, Ph.D. companies, such as the three Global Vice President, Healthcare Strategy, Oracle SPEAKERS represented on the panel, and for small businesses in Trevor Hawkins, Ph.D. the services and IT sectors. Chief Strategy Officer, Siemens Healthcare Diagnostics E. Kevin Hrusovsky President of Life Sciences & Technology, PerkinElmer ABOUT US 2:45 p.m. Conversation: Moderator: Robert Tepper, M.D. Genetics and the Law Partner, Third Rock Ventures There are conflicting views Laura Coruzzi, Ph.D., J.D. regarding Intellectual Partner, Jones Day Property for genetic tests. ORGANIZING The panel will offer opposing David Resnick, Esq. COMMITTEE views on prominent recent Partner, Co-Leader Patents, Nixon Peabody litigation and consider how Risa Stack, Ph.D. investors see the impact of Partner, Kleiner Perkins Caufield & Byers the legal decisions. 3:45 p.m. Break 4:15 p.m. International Commitments Moderator: Jeffrey Elton, Ph.D. to Personalized Medicine Managing Director, Accenture Many countries are Professor Abraham Israeli, M.D., M.P.H., M.B.A. considering and developing Chief Scientist of the Ministry of Health, plans to implement the Head, Department of Health Policy, Health Care Management principles of personalized and Health Economics, Hebrew University – Hadassah medicine. Are there lessons Faculty of Medicine; Professor, Hebrew University – from these efforts that the Hadassah School of Public Health, Jerusalem, Israel U.S. can learn from? How can we make personalized Michael Hayden, M.D., Ph.D. medicine a world-wide Director and Senior Scientist, effort? Center for Molecular Medicine and Therapeutics (CMMT), University of British Columbia, Vancouver, Canada Ola Myklebost, Ph.D. Senior Scientist and Group Leader, Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Norway Ming Qi, Ph.D. Professor, Zhejiang University School of Medicine, China 5:15 p.m. Reception Elements Café 8TH ANNUAL PERSONALIZED MEDICINE CONFERENCE | 7 Program Thursday, November 29, 2012 8:30 a.m. Keynote William Hait, M.D., Ph.D. Global Head of Janssen R&D, Johnson & Johnson Introducer: John Niederhuber, M.D. Professor of Oncology & Surgery, Johns Hopkins University School of Medicine; Former Director of the National Cancer Institute; Executive Vice President, Inova Health System; CEO, Inova Translational Medicine Institute 9:00 a.m. Genetics in Medical Moderator: M. Kathleen Behrens Wilsey, Ph.D. Practice President & CEO, KEW Group Each institution Joe Vockley, Ph.D. represented in this panel Chief Operating Officer, Chief Scientific Officer is making efforts to bring Inova Translational Medicine Institute personalized medicine to their patients. What are A. John Iafrate, M.D., Ph.D. the different approaches Associate Chief of Pathology, Massachusetts General Hospital, Center for that are being used? How Integrated Diagnostics are they evolving? What Mia Levy, M.D.,
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