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= Abstract =
Expression of P53. Bcl-2 Proteins and Hormone Receptors in Human Breast Cancer
Choung Han Lee, M.D.
Department of Surgery Kosin University College of Medicine
In a study of 56 breast cancer patients (infiltrating ductal carcinoma) with a follow-up period of more than 5 years, bcl-2 and p53 oncoprotein were detennined by immunohistochemistry. The aims of this study were two folds: (1) to detennine whether bcl-2 and p53 are expressed in breast cancer and its possible role in cell transfonnation, on the light of the relationship to estrogen and progesterone receptors, and (2) to assess whether bcl-2 and p53 immunoreactivity is associated with important clinicopathological parameters and with patient survival, including estrogen and progesterone receptors. Twelve of 56 (21.4%) carcinoma were Bcl-2 positive, and seventeen (30.4%) were p53-positive. A positive relationship was seen between bcl-2 and estrogen receptor (ER), with 11 of 12 (91.7%) bcl-2 positive tumors being ER positive (O.05
O.05). A strong negative relationship was observed between p53 and ER with seven· of 17 (52.9%) p53 positive tumors being ER positive (p