Postdoctoral position for 7 months

Institut Charles Sadron in collaboration with the laboratoire de Biomatériaux et Bioingénierie

New antibacterial dendritic surfaces based on for the treatment of implants

Advisors: Fouzia Boulmedais ([email protected]) and Delphine Chan-Seng ([email protected])

One patient over twenty admitted to hospitals suffers from nosocomial infections acquired in care facilities. The appearance of bacteria resistant to antibiotics leads to an increase in these infections generally associated to invasive methods requiring medical devices (catheters, implants). Thus, it is necessary to develop new strategies to prevent these infections from the biomaterials used.

The research project will deal with the development of new water-soluble antibacterial polymers based on peptide units. In this context, peptide-bearing monomers will be synthesized by solid- phase peptide synthesis, polymerized by reversible addition-fragmentation chain transfer (RAFT) controlled radical polymerization, characterized and investigated regarding their physico-chemical properties. The effect of the concentration, ionic strength of the aqueous solution and the temperature will be studied. The study of the bactericide effect of these polymers will be conducted at the laboratoire de Biomatériaux et Bioingénierie (). These biomaterials functionalized with these new polymers should present a bactericide effect.

The candidate should hold a Ph.D. degree or equivalent in the field of with a strong interest for interdisciplinary research at the interface of and . The candidate should have good knowledge in chemistry and physico-chemistry, purification techniques of small and polymers, their characterization and be willing to evolve in an interdisciplinary project. No skills in biology are requested. The candidate should be rigorous, systematic with organizational skills. He/she should be able to report his/her progress and data in a concise and precise manner and be able to work independently as well being a team player.

Institut Charles Tél. : 33 (0)3 88 41 41 60 23 rue du Loess Sadron BP 84047 Fax : 33 (0)3 88 41 40 99 CNRS 67034 Strasbourg cedex 2 http://www.ics-cnrs.unistra.fr