Emtree Terms Changed in January 2019 1

Emtree Terms Added and Changed (January 2019)

This is an overview of new terms added and changes made in the first Emtree release in 2019.

Overall, Emtree has grown by 709 preferred terms (114 drug terms and 595 non-drug terms) compared with the previous version released in September 2018. In total Emtree now counts 82444 preferred terms.

Because the terms added include replacements for existing preferred terms (which become synonyms of the new terms) as well as completely new concepts, the number of terms added exceeds the net growth in Emtree. Other changes could include the merging of two or more existing preferred terms into a single concept.

The terms added and changed are summarized below and specified in detail on the following pages.

Emtree Terms Added in January 2019

739 new terms (including 30 replacement terms and promoted synonyms) have been added to Emtree as preferred terms in version January 2019 (compared to September 2018):

 128 drug terms (terms assigned to the Chemicals and Drugs facet).  611 non-drug terms (terms not assigned as Chemicals and Drugs).

The new terms (including the replacement terms and the promoted synonyms) are listed as Terms Added on the following pages. Note that many of these terms will have been indexed prior to 2019 (typically as candidate terms), sometimes for several years, before they were added to Emtree.

Emtree Terms Changed in January 2019

30 terms (15 drug terms and 15 non-drug terms) from Emtree September 2018 have been replaced by 30 different terms in January 2018 (15 drug terms and 15 non-drug terms).

Of these, 25 terms (12 drug terms and 13 non-drug terms) are new (e.g. new generic names for drug chemical names) and have been assigned creation date 2019; the remaining 5 replacement terms (3 drug terms and 2 non-drug terms) were already present in Emtree.

No drug terms were replaced by a non-drug term, 0 non-drug term were replaced by a drug term. No preferred terms were deleted.

Changes are presented in alphabetical order of the new terms. Emtree Terms Added in January 2019 2

Drug terms

1 palmitoyl 2 oleoyl sn glycero 3 canine leptospirosis canine parainfluenza phosphoglycerol sodium salt virus rabies virus vaccine AAV-CNGA3 canine leptospirosis canine parainfluenza abelacimab virus vaccine abo 202 carbamide peroxide abrocitinib carboplatin plus sodium valproate Actaea racemosa extract cenupatide adriforant ceralasertib ag31 chemokine receptor CX3CR1 antagonist aln ttrsc02 chlorpheniramine maleate plus alteminostat paracetamol altizide plus spironolactone cinpanemab amelparib cintirorgon amlivirsen clascoterone amlodipine plus indapamide coblopasvir ampreloxetine cotadutide animal protein CRISPR associated endonuclease Cas9 aticaprant crovalimab Avena sativa extract cystine bis(n' methylpiperazide) avoplacel dcr l1360 azelaprag diterpene alkaloid bamadutide dolutegravir plus lamivudine plus tenofovir banned ingredient disoproxil bcx 7353 donanemab belapectin doravirine plus lamivudine plus tenofovir bempegaldesleukin disoproxil bevifimod Echinacea angustifolia extract bg00011 econazole plus triamcinolone acetonide bintrafusp alfa egt 101 blarcamesine egt 201 bovine mastitis vaccine egt 301 brilaroxazine elifactant btz 043 elopultide budigalimab estradiol plus progesterone calcium regulating agents ethinylestradiol plus segesterone acetate camsirubicin formic acid plus oxalic acid canine adenovirus canine distemper virus glycosidase activator canine leptospirosis canine Golgi matrix parainfluenza virus canine parvovirus granulin rabies virus vaccine h3b 6527 canine adenovirus canine distemper virus harmala alkaloid canine leptospirosis canine hm15136 parainfluenza virus canine parvovirus hydrolase activator vaccine infectious laryngotracheitis Marek disease canine adenovirus canine distemper virus vaccine canine parainfluenza virus canine inz 701 parvovirus vaccine ionis-maptrx Emtree Terms Added in January 2019 3 islatravir oxycodegol Janus kinase 1 inhibitor pea protein lademirsen pepinemab lbs 008 phenyltrope lerociclib polyyne lipoglycopeptide quetmolimab lorecivivint redipultide mannose 1 phosphate regn eb3 mannose 1 phosphate lipid complex rgx 111 meat protein risuteganib methyltransferase activator secretagogue mitazalimab segesterone acetate mRNA 3704 shellfish protein mrt5201 shp 654 Mycoplasma synoviae vaccine smoking cessation agent myrrh sodium sulfate cotransporter n (2 bromophenyl) 9 methyl 9 steroid hormone receptor stimulating azabicyclo[3.3.1]nonan 3 amine agent naxitamab substandard drug NPC intracellular cholesterol transporter 1 sulfate transporter nsr rep1 tomaralimab occlusion body matrix protein transferase activator olutasidenib troriluzole otl 101 vutrisiran otl 201 wve 210201 oxindole derivative Emtree Terms Added in January 2019 4

Non-drug terms

antiparasitic activity abscopal effect antiplasmodial activity acaricidal activity antiplatelet activity acetabular liner antithrombogenic activity acetabular shell antithrombotic activity acidified milk antitrypanosomal activity acidophilus milk antitrypanosomatid activity acoustic artifact antitumorigenic activity actinic prurigo antitussive activity additive effect apple pomace adulticidal activity aptasensor Adverse Childhood Experiences Questionnaire aquagenic urticaria Aegilops Astragalus propinquus Aegilops speltoides Autographa californica multiple nucleopolyhedrovirus aerobic granular sludge Autographa californica nucleopolyhedrovirus aerobic sludge B10.RIII mouse aggressive driving Bacillus velezensis agro-industrial waste bacteriostatic activity algicidal activity baked milk allogenic cell bat pollination almond milk bee pollination aloe juice benefit-finding amensalism bergamot juice amikacin resistance berry juice aminoglycoside resistance big data amoebicidal activity bikeability Amphotropic murine leukemia virus biliary microlithiasis anaerobic ammonium oxidation anaerobic granular sludge bilious vomiting anaerobic sludge biocidal activity anammox sludge biofilm matrix animal pollination biostatic activity antagonistic effect bird pollination antagonistic pleiotropy birth season Anthocoridae birth setting anti-acari activity bitter orange juice antiaging activity blackcurrant juice antialgal activity blueberry juice antiallergic activity boiled milk antiamoebic activity brachial plexus palsy antiapoptotic activity breaking strength antibiofilm activity Brettanomyces bruxellensis antibiotic resistome Bruchidae anticariogenic activity buffalo milk anticestodal activity built environment antifibrotic activity Burkholderiales Genera incertae sedis antifilarial activity cactus pear juice antiherpetic activity Calliphora vomitoria antihydatid activity Calothrix antilarval activity cannabinoid hyperemesis antileishmanial activity canthus antileukemic activity Carangaria incertae sedis antimutagenic activity carbapenem resistance antinematode activity carbapenem resistant Acinetobacter baumannii antineoplastic protocol carbapenem resistant Escherichia coli antiobesity activity carbapenem resistant Klebsiella pneumoniae antiosteoporotic activity carbapenem resistant Pseudomonas aeruginosa Emtree Terms Added in January 2019 5 cardiac rhythm management device dairy wastewater caregiver burnout Daphniphyllaceae carotid artery balloon injury Daphniphyllum cashew apple juice daptomycin resistance CAST/EIJ mouse data aggregation cattle manure data correlation cefotaxime resistance data science ceftazidime resistance data system ceiling and floor effect data visualization ceiling effect (pharmacology) deep learning ceiling effect (statistics) Dehalobacter Cenchrus purpureus dentist patient relationship Centropomidae Descurainia cephalomedullary nail Descurainia sophia cerulein-induced acute Diadema cerulein-induced dialectical behavior therapy character displacement Diatraea chemotherapy induced nausea Dicentra cherry juice digital literacy cherubism Dioscorea zingiberensis childhood adversity disability study childhood psychosis disenfranchised grief childhood trauma disrespect chiral separation distillery waste Chlamydia abortus distillery wastewater Chlamydia felis Diversity Outbred mouse chocolate milk doctor patient relationship chokeberry juice donkey milk ciprofloxacin resistance donor milk ciprofloxacin resistant Escherichia coli doogh citrus juice dry cupping citrus processing waste e-waste Cladophora ear tissue Cladophora glomerata economic status clam juice edema fluid clear cell chondrosarcoma Edmonton Frail Scale clinical trial protocol Edmonton Obesity Staging System Clostridium ljungdahlii Edmonton Symptom Assessment System cold allodynia egocentricity cold hyperalgesia electrician colistin resistance electrochemical sensor Collaborative Cross mouse electroplating waste competitive exclusion electroplating wastewater complicated grief embarrassment compression artifact emotional neglect concentration (parameter) endobronchial valve condensed milk endocarp cone dystrophy Epiphyas Consolida Epiphyas postvittana construction and demolition waste Epipremnum cow milk Epipremnum aureum craniofacial fibrous dysplasia Equartevirus Crotalus durissus equipment and supplies utilization Crotalus durissus terrificus erythromycin resistance cupping therapy European Organization for Research and Treatment cyberbullying of Cancer Quality of Life Questionnaire Core 30 cybersickness European Quality of Life 5 Dimensions 3 Level cyberstalking questionnaire dairy cream European Quality of Life 5 Dimensions 5 Level dairy waste questionnaire Emtree Terms Added in January 2019 6

European Quality of Life 5 Dimensions questionnaire grey literature European Quality of Life 5 Dimensions Visual gun violence Analogue Scale hair follicle bulge evaporated milk hand pollination ex-smoker Harpacticoida experimental HCCLM6 cell line experimental meningitis health workforce experimental motor dysfunction healthy user bias experimental urolithiasis heat allodynia extensive drug resistance heat hyperalgesia extensively drug resistant Acinetobacter baumannii B virus genotype E facilities and services utilization HER2 chromogenic in situ hybridization kit family separation HER2 test kit feculent vomiting Heterorhabditis fermented dairy product hippocampal fissure fermented milk drink history of pharmacy fetal bovine serum hook effect Flacourtia horse milk flavored milk host bacterium interaction flexural strength host fungus interaction flocculent sludge host interaction floor effect host microbe interaction fluoroquinolone resistance host pathogen vector interaction fluoroquinolone resistant Escherichia coli host vector interaction focused assessment with sonography for trauma household economic status food processing waste human epidermal growth factor receptor 2 negative forensic psychology breast cancer fragmented sleep hyperemesis freezing of gait hypocholesterolemic activity fruit and vegetable waste hypolipidemic activity fruit peel Ichthyophthirius fruit pulp Ichthyophthirius multifiliis fruit waste illiteracy fruit wine Ilyanassa Functional Assessment of Cancer Therapy Ilyanassa obsoleta Functional Assessment of Cancer Therapy Brain image artifact Functional Assessment of Cancer Therapy Breast implementation science Functional Assessment of Cancer Therapy Cognitive implementation scientist Function indication bias Functional Assessment of Cancer Therapy Colorectal informatician Functional Assessment of Cancer Therapy Fatigue inner filter effect Functional Assessment of Cancer Therapy General insect pollination Functional Assessment of Cancer Therapy Head and instrument detection limit Neck intermediate care unit Functional Assessment of Cancer Therapy Prostate intermethod reliability Functional Assessment of Chronic Illness Therapy international health regulation Functional Assessment of Chronic Illness Therapy internet access Fatigue Scale internet of things Functional Assessment of Chronic Illness Therapy involuntary euthanasia Spiritual Well Being Scale iris stroma fungistatic activity kinetic isotope effect polyp Krippendorff's alpha coefficient GATA2 deficiency larvicidal activity genetic profile larvistatic activity gentamicin resistance lateral canthus Glaucoma chattoni Lates glymphatic system Lates calcarifer GRADE approach Lates niloticus granular sludge lead time bias grape pomace leishmanicidal activity Emtree Terms Added in January 2019 7

Leucanthemum nematicidal activity Lilium longiflorum Neolentinus lime juice neurolymphomatosis limit of agreement New Zealand obese mouse limit of blank non small cell lung cancer detection kit lipoabdominoplasty null result liquid waste nurses improving care for healthsystem elders LLC-PK1 cell line nursing shared governance low fat milk nutshell (structure) macrolide resistance obstetrical brachial plexus palsy Maesa off-target effect magic angle effect olive mill waste mail order pharmacy olive mill wastewater mandarin juice olive pomace mango juice omitted variable bias mathematician online harassment matrix effect online pharmacy McGurk effect online social network mead (beverage) opioid induced hyperalgesia meaning-making Orius meat juice Orius insidiosus mechanical allodynia outcome reporting bias medial canthus ovicidal activity medical countermeasure oxacillin-resistant Staphylococcus aureus melanoma test kit paper mill mentalization parasiticidal activity mentalization-based treatment partial volume (imaging) mesocarp participatory action research method detection limit pasteurized milk microbe-microbe interaction PC12 cell line (pheochromocytoma) microbial competition peanut milk microbial interaction pear juice microbicidal activity pedal ganglion microbistatic activity pediatric traumatic brain injury microlithiasis Pelvic Organ Prolapse Quantification micromolding penicillin resistant Streptococcus pneumoniae milk by fat content perivitelline space milk by origin pharmacist patient relationship milk by preservation pharmacy (discipline) milkshake pharmacy (shop) mine waste pig milk minimum detectable activity Pinctada fucata minimum detectable change plant bacterium interaction Mitragyna speciosa plant juice mold plant pollinator interaction molluscicidal activity plant virus interaction monostotic fibrous dysplasia plant-based milk Morisky Medication Adherence Scale plastic waste Morisky-Green-Levine test Plectranthus amboinicus multidrug resistant Acinetobacter baumannii Plectranthus barbatus multidrug resistant Enterobacteriaceae Plectranthus scutellarioides multidrug resistant Escherichia coli pleopod multidrug resistant Klebsiella pneumoniae pleural ganglion multidrug resistant Pseudomonas aeruginosa Pocillopora municipal waste Pocillopora damicornis municipal wastewater polymyxin resistance myopericytoma polyostotic fibrous dysplasia Myrsine population health management Nannochloropsis oceanica post-Lyme disease syndrome Nassariidae posttraumatic growth (psychology) Emtree Terms Added in January 2019 8 poultry manure simulator sickness prior authorization Sivash prosthesis proapoptotic activity skim milk procedures and techniques utilization sleep debt proepicardium sleep fragmentation (procedure) professional burnout sludge bulking prolonged grief sludge management prostate specific antigen test kit sludge reduction protein carbamylation social desirability bias protoscolex sorghum juice protoscolicidal activity sour cream protozoacidal activity sour dairy product prurigo nodularis specialty pharmacy prurigo pigmentosa speeding (driving) psychogenic vomiting spermicidal activity public expenditure spillover (imaging) publication bias sponsorship bias pulmonary alveolar microlithiasis stage 1 sleep pulp and paper industry stage 2 sleep pulp and paper industry waste statistically significant result pulp and paper mill wastewater statistician pupicidal activity strawberry juice PWK/PhJ mouse streptomycin resistance quality improvement study streptozotocin-induced diabetic nephropathy quantitative light-induced fluorescence streptozotocin-induced hyperglycemia radiation induced nausea and vomiting student burnout radioactive waste management sugar beet juice radioactive wastewater sugar beet pulp radiofrequency catheter ablation sugarcane juice radiofrequency therapy survival bias raw milk sweetened condensed milk reckless driving sweetened milk reduced fat milk swine manure regenerative endodontics syndemic REM sleep latency synergistic effect reporting bias tactile allodynia reproductive interference tandem affinity purification reserpine-induced hypothermia tannery sludge respect tannery waste response bias tannery wastewater retention in care testicular microlithiasis reversed phase ultra performance liquid therapeutic alliance chromatography thermal allodynia rifampicin resistance thermal hyperalgesia road rage Thiomonas ROS 17/2 cell line thoracic disk ROS cell line (osteosarcoma) Tigriopus rose wine Tigriopus japonicus Rutilus tobramycin resistance Rutilus rutilus toe nail Schefflera total hip replacement scolicidal activity traffic pollution screen time transplant rejection test kit Scylla paramamosain tritrophic interaction sedentary time trypanocidal activity seed sludge UHT milk self reference effect United Nations Educational, Scientific and Cultural self-selection bias Organization sheep milk universal health insurance Simon task unresolved grief Emtree Terms Added in January 2019 9 vaccine hesitancy vaccinologist vaccinology vegetable waste ventilation-perfusion scan veterinary clinical trial veterinary pharmacy virostatic activity virucidal activity walkability wall effect Wallemia Wallemiales waste site watermelon juice weight trajectory (body weight) Weissella cibaria wet cupping wheat grass juice whey permeate whole milk wind pollination winery waste winery wastewater Withania coagulans within host interaction WSB/EiJ mouse yak milk Zweymuller prosthesis Emtree Terms Changed in January 2019 1

Drug terms

New or pre-existing term Old (replaced) term * indicates pre-existing term These terms become synonyms of the new term

Actaea racemosa extract Cimicifuga racemosa extract altizide plus spironolactone aldactazine bevifimod staphylococcus protein A canine adenovirus canine distemper virus canine adenovirus plus canine distemper virus plus canine parainfluenza virus canine parvovirus canine parainfluenza virus plus canine parvovirus vaccine vaccine chlorpheniramine maleate plus paracetamol coricidin Echinacea angustifolia extract Echinacea angustiflora extract inotersen* ionis ttrrx iodinated poppyseed oil* ethiodized oil lorecivivint adavivint mitazalimab vanalimab oxycodegol loxicodegol segesterone acetate elcometrine tomaralimab opn 305 vutrisiran votrisiran zolbetuximab* claudiximab

Emtree Terms Changed in January 2018 2

Non-drug terms

New or pre-existing term Old (replaced) term * indicates pre-existing term These terms become synonyms of the new term cardiac rhythm management device pacemaker Chlamydia* Chlamydophila concentration (parameter) concentration (parameters) doctor patient relationship doctor patient relation e-waste electronic waste fermented dairy product fermented milk product HCCLM6 cell line LM6 cell line health workforce health care manpower LLC-PK1 cell line LLC PK1 cell line mold mould paper mill paper industry PC12 cell line (pheochromocytoma) PC12 cell line pharmacy (shop) pharmacy ROS cell line (osteosarcoma) ROS cell line workforce* manpower