CURRICULUM VITAE

PERSONAL DETAILS

Name: Dr Wee Kooi Cheah Gender: Male Address: Hospital Taiping Jalan Taming Sari 34000 Taiping .

MAIN POSITIONS

Since 2012 Geriatrician and Physician, Department of Medicine Taiping Hospital Since 2015 Head of Clinical Research Centre, Taiping Hospital Since 8 Jan 2019 Head of Medical Department, Taiping Hospital

NATIONAL POSITION Trainer for the National Geriatric Subspecialty in Ministry of Health since 2014 Supervisor for Master Students (Internal Medicine and Family Physician) for University Malaya since 2015 Malaysian Medical Council Specialist Evaluation Sub-Committee (Geriatric) JKKPK 19 Feb until 18 Feb 2021

STATE POSITION

Head of Geriatric Medicine Clinical Service for the State of Perak (Appointment Jan 2016 to Jan 2019) Perak State Committee Member for “Pain Free and Pain as the 5th Vital Sign Programme” Ref: JKN PK 600-22/1/119(3) dated 29 Dec 2017

HOSPITAL POSITIONS (Hospital Taiping) Since 2014 Hospital Quality Committee (Chief Coordinator) Since 2014 Hospital Safety Committee Since 2015 Hospital Antibiotic Stewardship Committee Since 2018 Hospital Medicine and Therapeutic Committee Since 01 Jan 2019 Hospital Infection Control and Antibiotic Committee (HIACC) Since 08 Jan 2019 Cluster Medical and Dental Advisory Committee Since 2019 Northern Perak Cluster Hospital Committee (Head of Medical Cluster Directorate) Since 2019 Northern Perak Cluster Hospital- Cluster Management Committee

OTHER POSITIONS

Since 2012 Visiting Geriatrician, Sungai Siput Hospital and State General Hospital Since Feb 2019 Visiting Geriatrician, Hospital Seri Manjung Since 2011 Honorary Senior Lecturer of Medical College Since 2019 Adjunct Associate Professor of the Quest International University Perak Since 2016 Malaysian Society of Neuroscience Movement Disorders Council Member Since 2019

Since 2017 President of the Diabetic (Taiping Branch)- (Previously known as Diabetic Society of Malaysia, Taiping Branch) Since 2014 Medical advisor of the Perak Society of Parkinson Disease

PAST POSITION

2014 to Feb 2015 Deputy Head of Clinical Research Centre, Taiping Hospital 15th Feb 2015 to 31st July 2015 Acting Head of Department, Department of Medicine, Taiping Hospital 2008 -2016 Vice president of the Diabetic Malaysia (Taiping Branch)- (Previously known as Diabetic Society of Malaysia, Taiping Branch) 2015-2019 Adjunct Assistant Professor of the Quest International University Perak Committee Member for National Specialist Register (NSR) – Geriatric Medicine 4th January 2016 to 4th January 2019

PROFESSIONAL REGISTRATIONS

Academy of Medicine Malaysia – Ordinary member 2012 - now National Specialist Register, Internal Medicine – 2012 – now National Specialist Register, Geriatric Medicine- 2012 – now The Malaysian Society of Geriatric Medicine (MSGM) – No. L13- life member since 2013 The Malaysian Society of Neuroscience (MSN) No MSN318/L– life member since 2013

AWARDS Civil Service Award of Excellent Service 2006 Civil Service Award of Excellent Service 2012 Civil Service Award of Excellent Service 2019

EDUCATIONAL BACKGROUND

Undergraduate training 1998-2003 University Malaya – qualification MBBS (Mal)

Postgraduate training 2006 Royal College of Physicians of United Kingdom- qualification MRCP (UK)

Fellowship in Geriatric Medicine from Tan Tock Seng Hospital, Singapore (2011)

Fellowship in Geriatric Medicine (MOH) March 2012

Fellow Royal College of Physician (London) – May 2016

OTHER QUALIFICATIONS Good Clinical Practice Certification

Certificate of credentialing for core procedure in internal medicine, MOH Malaysia

IOF (International Osteoporosis Federation) Osteoporosis diagnosis and Densitometry Certification

Washington University School of Medicine certification as a Clinical Dementia Rating (CDR) rater – 2011

American Independent Board of Medical Examiners- 2016

WORKING EXPERIENCE

2003-2005 House officer in Taiping Hospital

2005 (Jan-Mac) Medical officer in emergency department Taiping Hospital

2005 (Mac-April) Medical officer in Medical Department Taiping Hospital

2005 (April- Nov) Medical and Health officer in Manjung district, Beruas Health Clinic and emergency department

2005(Nov)-2006(Nov) Medical officer in Medical Department Taiping Hospital

2006 1 week attachment in infectious disease unit Hospital Sungai Buloh

2006-2008 Clinical Specialist in Medical Department in Taiping Hospital

1 Sept 2008 till Clinical Specialist (Geriatric) in Taiping Hospital 31 May 2009

1 June 2009 till Clinical Specialist (Geriatric) in Neurology Department, Penang 31 Aug 2009 General Hospital

Sept 2009 till Clinical Specialist (Geriatric) in Geriatric Unit, Medical 31 May 2010 Department General Hospital

1 June 2010 till Clinical Specialist (Geriatric) in Geriatric Division, Medical 26 Dec 2010 Department of University Malaya Medical Centre

27 Dec 2010 till Fellowship training in Geriatric Medicine, Department of 26 June 2011 Geriatric Medicine, Tan Tock Seng Hospital, Singapore

27 June 2011 Clinical Specialist (Geriatric) in Geriatric Division, Medical 31 Aug 2011 Department of University Malaya Medical Centre

1st Sept 2011 till Physician and Clinical specialist in geriatric medicine, Medical March 2012 Department Taiping Hospital

March 2012 till Consultant Physician and Geriatrician, Medical Department Present Taiping Hospital, Visiting Geriatrician to Ipoh General Hospital and Sungai Siput Hospital

CLINICAL TRIAL EXPERIENCE

2007-2008 Site Investigator for International Diabetes Management Practise Study

Co-investigator for the following trials:

2007 A multicenter, randomized, double-blind, placebo-controlled, 36 weeks study to evaluate the efficacy and safety of MK 0524-A in patients with type 2 diabetes mellitus

Efficacy and safety study of Ranbaxy’s CT 07-03 in the treatment of primary hypercholesterolemia

2008 A randomized, double blind, placebo-controlled parallel group efficacy and safety study of BI 1356 (5mg administered orally once daily) over 24 weeks, in drug naïve or previously treated type 2 diabetes mellitus patients with insufficient glycemic control

A 76 weeks, worldwide, multicenter, double blind, randomized, placebo controlled study to assess the tolerability and efficacy of MK 0859 when added to on going therapy with statin in patients with hypercholesterolemia or mixed dyslipidemia

2009 A 78 weeks open label extension to trial assessing the safety and efficacy of BI 1356 (5mg) as monotherapy or in combination with other antidiabetic medication in type 2 diabetic patients

A multicenter, randomized, double blind, placebo controlled dose range finding clinical trial of MK 0941 in patients with type 2 diabetis mellitus with inadequate glycemic control on insulin

Determining the prevalence of osteoporosis and predictors of bone mineral density in chronic kidney disease stage 2 and 3 in type 2 diabetic patients

A phase III, double-blind, placebo-controlled, randomized trial to determine the efficacy and safety of a dose range of 50 to 100mg/day of safinamide, as add-on therapy, in subjects with idiopathic Parkinson’s Disease with motor fluctuations, treated with stable dose of levodopa and who may be receiving concomitant treatment with stable doses of a dopamine agonist, an anticholinergic and/or amantadine.- SETTLE, safinamide in IPD with motor fluctuations, as add-on to levodopa

2010 Prospective community based stroke incidence and outcome study in a suburban population of South West Penang Island (The PEARL study)- on going

2011 Investigator in: A Randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes after Treatment with Sitagliptin in Patients with Type 2 Diabetes Mellitus and Inadequate Glycemic Control

A Phase III, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety and Efficacy of Sitagliptin Compared With Glimepiride in Elderly Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control

A multicentre, international, randomised, parallel group, double blind study to evaluate Cardiovascular safety of linagliptin versus glimepiride in patients with type 2 diabetes mellitus at high cardiovascular risk. Steering committee for the validation of Malay version: Montreal Cognitive Assessment (M:MoCA)

2012-2013 (co Investigator)

A 76 week, Worlwide,multicetre ,Double Blind, Randomized Placebo Controlled Study to Access the tolerability and efficacy of Anacetrapib when added to Ongoing Therapy with Statin in Patients with hypercholesterolemia or mixed hiperlipidemia.

A Multicentre, Randomized, Double-Blind, Active-Controlled Study to Evaluate the Durability of the Efficacy and Safety of Alogliptin Compared to Glipzide When Used in Combination with Metformin in Subjects with Type 2 Diabetes.

A Randomized Placebo-Controlled Trial to Evaluate Cardivascular Outcomes after Treatment with Sitagliptin in Patients with Type 2 Diabetes Mellitus and Inadquate Glysemic Contril on mono-or Dual Combination Oral Antihyperglycemic Theraphy Sitagliptin.

A phase III, Multicentre, Double-Blind, Randomized, Active-Controlled Study to Evaluate the safety and Efficacy of Sitagliptin Compared With Glimipiride in Elderly Patients with Type 2 Diabetes Mellitus with Inadequate Glycemic control

A Multicentre, Randomized, Double-Blind, Active-Controlled, Phase 3 Study to Evaluate the Efficiacy and Safety of TAK-875 25mg and 50mg Compared to Glimieride When Used in Combination with Metformin in Subjects with Type 2 Diabetes

A Phase 3, Randomized, Double-blind, Placebo=controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Ranolazine when Added to Glimepiride in Subject with Type 2 Diabetes Mellitus

2013 (site principal investigator)

Malaysia Parkinson Disease Genetic Study Multicentre validation of Malay Montreal Cognitive Assessment Tool

2013- Feb 2015 (sub Investigator)

A 76 week, worldwide, multicentre, double blind, randomized placebo controlled study to access the tolerability and efficacy of Anacetrapib when added to ongoing therapy with statin in Patients with hypercholesterolemia or mixed hyperlipidemia

A randomized placebo-controlled trial to evaluate cardiovascular outcomes after treatment with sitagliptin in patients with type 2 diabetes mellitus and inadequate glycemic control on mono or Dual combination oral antihyperglycemic therapy with sitagliptin

A multicentre, international, randomized, parallel group, double blind study to evaluate cardiovascular safety of linagliptin versus glimepiride in patients with type 2 diabetes mellitus at high cardiovascular risk

OPAL 63623872FLZ2002 Influenza study 2016-2017

2015 - 2017 Industrial sponsored trial ( Site Principle Investigators) “ A randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes after Treatment with exanitide once weekly in Patients with Type 2 Diabetes Melitus (EXenatide Study of Cardiovascular Event Lowering Trial (EXSCEL)”

CARMELINA study – close up 2018 CAROLINA study – close up 2018

2016- 2018 Investigator Initiated Trial (site Principle Investigators) Validation study of the Visual Cognitive Assessment Tool SATURN study (Tocotrienol in acute ischemic stroke)

2017-2018 RSV2003 trial

2018 A multinational, multi-center, randomized, double-blind, active comparator, phase III clinical trial to evaluate the efficacy and safety of donepezil transdermal patch in Alzheimer’s disease Janssen SHAPPIRE Janssen DIAMOND

PUBLICATIONS

Journal

1. Cheah WK, Lim TT, Eow GB, et al. 2010. Autoimmune Encephalopahty with high Ca123 Titre. Medical Journal of Penang Hosp 8: 31-32. 2. Cheah WK, Han HC, Chan PC, et al. 2012. Multidimensionality of the Zarit Burden Interview across the severity spectrum of cognitive impairment. An Asian perspective. International Psychogeriatric 24(11): 1846-1854. (impact factor: 2.24 in 2011) DOI 10.1017/S104161021200110X 3. Cheah WK, Lee FS, Yau WK. 2012. Assessing the utility of FAB to MMSE ratio as a cognitive screening tool for diagnosis of frontal lobe pathology in elderly with behavioural manifestation. Medical Journal of Penang Hosp. 4. Neelamegam M, Looi I, Cheah WK, Narayanan P, A Hamid AM, Loke MO, 2013. 5. Stroke incidence in the South West District of the Penang Island, Malaysia PEARLs: Penang Acute Stroke Research Longitudinal Study. Preventive Medicine. (Impact factor: 3.22 in 2013) 6. Cheah WK, Choy MP, Ramanathan GRL, 2013. Overestimation of the Weekend and Off-hour Effect in a Public Hospital in Malaysia. Malaysia Medical Journal 68(1) : 89-90. (Letter to editor) 7. Lim WS, Cheah WK, Ali N, et al. 2013. Worry about performance: a unique dimension of caregiver burden. International Journal of Geriatric Psychiatry 26(4): 677-686. doi:10.1017/S1041610213002445 srep18224 (impact factor: 2.866 in 2013) 8. Cheah WK, The HL, Huang DXH, et al. 2014. Validation of Malay version of Montreal cognitive assessment in patients with cognitive impairment. Clinical Medicine Research 3(3): 56-60. DOI 10.11648/j.cmr.20140303.11. Epub 2014 April 30. 9. Cheah WK, Ng KS, Marzilawati AR, Lum LCS. 2014. A Review of Dengue Research in Malaysia. Medical Journal of Malaysia 69(SA): 59-67. 10. Au A, Griffiths LR, Cheng KK, Cheah WK, Looi I, Loo KW. 2015 The Influence of OLR1 and PCSK9 Gene Polymorphisms on Ischemic Stroke: Evidence from a Meta-Analysis. Scientific Reports 5: 18224: DOI: 10.1038/srep18224 (impact factor: 5.578 in 2014) 11. Woon YL, Hor CP, Hussin N, Zakaria A, Goh PP, Cheah WK. A Two-Year Review on Epidemiology and Clinical Characteristics of Dengue Deaths in Malaysia, 2013-2014. PLoS Negl Trop Dis. 2016 May 20;10(5) 12. Tan WL, Soelar SA, Mohd Suan MA, Hussin N, Cheah WK, Verasahib K, Goh PP. Leptospirosis incidence and mortality in Malaysia. Southeast Asian J Trop Med Public Health. 2016 May; 47(3):434-40. 13. Lim Kean Ghee, Cheah Wee Kooi, 2016. A review of metabolic syndrome research in Malaysia. Med J Malaysia. Vol 71 Supplement 1 June 2016 14. Wee Kooi Cheah, Chee Peng Hor, Zariah Abdul Aziz, Irene Looi . A Review of Stroke Research in Malaysia from 2000 – 2014. Med J Malaysia. Vol 71 Supplement 1 June 2016 15. J. Thamibmaniam, N. Hussin, W.K. Cheah, K.S. Ng, P. Muninathan. Proposal of a Clinical Decision Tree Algorithm Using Factors Associated With Severe Dengue Infection. PLoS ONE 11(8): e0161696. doi:10.1371/journal.pone.0161696 2016 16. Loo KW, Au A, Menon S, Griffiths LR, Cheah WK, Looi Irene, Zhao J, Lee C, Alekseevna A M, Hassan MRA, Aziz ZA. Polymorphisms of MTHFR, eNOS, ACE, AGT, Apo E, PON1, PDE4D, and ischemic stroke: Meta analysis. Journal of Stroke & Cerebrovascular Disease. 2017 Nov 26; 2482-2493 (11) doi:http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.05.048 17. Rury RH, M. Angelyn B, Robert JM, et al. for the EXSCEL Study Group. Effects of Once-Weekly Exenatide on Cardiovascular Outcome in Type 2 Diabetes. NEJM, 2017 Sep. EESCEL Study Group: MALAYSIA: Alexander Tong-Boon Tan, Letchuman Ramanathan, Muhammad Radzi Abu Hassan, Florenece Tan, Tiong Kiam Ong, Siew Hui Foo, Rohana Abdul Ghani, Wee Kooi Cheah

Book

Eow GB, Goh TH, Lim TT, Cheah WK. Pacing the PACES: Tips for passing MRCP and Final MBBS. 2011(copyright obtained and published 2011)

Cheah WK. Parkinsonism. The Handbook on Geriatric Medicine. 2012. [Book chapter]

Cheah WK. Stroke. The Handbook on Geriatric Medicine. 2012. [Book chapter]

Cheah WK. Immobile Patient. The Handbook on Geriatric Medicine. 2012. [Book chapter]

On line publication (public education)

Appointed accreditator for MyHealth Portal for ‘warga emas’ for the following (both English and Bahasa Malaysia version) (2011-present): Physical change in elderly, giddiness, tremor in elderly, pain, where can I get information on elderly health, guide to choosing a nursing home, pain, confusion

Appointed writer and translator for MyHealth Portal for ‘hypertension’ for the following (2011 – present): Hypertension in the frail, postural hypotension, hypertension and stroke

PRESENTATION

Oral

Perak Annual Medical Research and scientific Conference 2009, Hospital Raja Permaisuri Bainun 11th December 2009- Determining the Prevalence of Osteoporosis and Predictors of BMD in CKD Stage 2 and 3 in Type 2 Diabetic Patients

Disproportionate Cognitive Screening Tools: FAB to MMSE scores as a screening tool for Frontal Lobe Pathology in Elderly Presenting with Behavioural Manifestation. 13th Asia Pacific Regional Conference of Alzheimer’s Disease International. Oct 2010 (International)

Cheah WK, Han HC, Chan PC, et al. Multidimensionality of the Zarit Burden Interview across the severity spectrum of cognitive impairment. An Asian perspective. Presented in the ASAD 15th June 2012 (International)– 1st prize

Perak Annual Medical Research and scientific Conference 2014, Hospital Permaisuri Bainun 2014- Validation of Malay version of Montreal cognitive assessment in patients with cognitive impairment (State level) – 2nd Prize

Poster International

Cheah WK, Ch’ng ASH, Huang DXH, Choy MP, Teh EE, Yusof YB, Looi I. Validation of the Malay Version of the Montreal Cognitive Assessment. 3rd Singapore International Neurocognitive Symposium. 5-6th April 2013, Hilton Singapore. (International)

ISPOR 4th Asia-Pacific Conference- Nov 2010 – Pharmacist-run Methadone Clinic in a Malaysian Public Health Center: Evaluating Patient Satisfaction and Quality of Life Outcomes (International)

A Descriptive Study on Patients’ Life Time Follow up in Memory Clinic in one Public Hospital in Malaysia. 13th Asia Pacific Regional Conference of Alzheimer’s Disease International. Oct 2010 (International)

A Descriptive Study on Patients Presenting to a Memory Clinic in Malaysia. 13th Asia Pacific Regional Conference of Alzheimer’s Disease International. Oct 2010 (International)

TEACHING EXPERIENCE

2007 Examiner for MRCP PACES Mock Examination in Taiping Hospital 2009-2011 Honorary Lecturer of Penang Medical College 2011- present Honorary Senior Lecturer of Penang Medical College

LECTURES GIVEN

1. Endocrine physiology and pathology in elderly. Perak Endocrine Update 2009 2. Rapidly progressive dementia – case presentation and approach. 2nd Advance in Neurology 2009. 3. Diabetes in elderly, 2010 Perak 4. Normal Pressure Hydrocephalus, 2010 Neurology Penang 5. Stroke risk reduction in operative patients, 2010 Neurology Penang 6. Introductory Talks on KPI Tools – CDT, GDS, CAM :2009,2010 HKL 7. Pressure Sore Prevention- Geriatric Multidisciplinary team updates workshop 2009, 2010 HKL 8. Developing a least restraint culture in elderly care- Geriatric workshop 2010, UMMC 9. Principles & tools for geriatric assessment – TTSH Geriatric Department CME 10. Multiple public talk on diabetes organized by Malaysia Diabetic Society 2008- 2011 11. Dementia update, 2011 Seberang Jaya, Penang 12. Tutorials and bedside teachings for MOs and medical students were done as part of day-to-day work practise. 13. Formal teaching sessions were done for medical students during 2009 on a bi weekly basis as a honorary lecturer of Penang Medical College 2014

1. Good Clinical Practice lectures organized by Hospital Sri Manjung, Hospital Taiping, Hospital Seberang Jaya, University Sains Malaysia (Penang branch) 2. Geriatric Service in National Geriatric Conference, Ipoh

2015

1. Defrosting Parkinson Disease- Regional Geriatric Conference, Kuching 2. Good Clinical Practice lectures organized by Hospital Seberang Jaya

COMMITTEE: NATIONAL LEVEL

2011- present Technical committee for the expansion of the MyHealth Portal (Ministry of Health) for the sub-portal of patients’ education for 1.Hypertension 2.Elderly group 2011 Committee member for the National Health and Morbidity survey (NHMS) 2012 for the elderly health 2012 Subjet Matter Expert (SME) for Intergrated open source Hospital Information system (Intergrasi OpenHIS) module clinical documentation Ref: (93)dlm.KKM/BPM/190/6/143Jld2 dated 5 Mac 2012 2014 Committee for the drafting Aged Health Care Act

COMMITTEE: HOSPITAL LEVEL

2014-2015 Committee for Hospital Safety 2014-2015 Medical Department Clinical Research Coordinator 2014-2015 Quality Assurance Project Coordinator (Hospital and Department) 2015-2017 Quality Assurance Project Coordinator (Hospital) 2015-2017 Antibiotic Stewardship Committee (Hospital) 2015-2017 Patient Safety Goal Committee (Fall)- (Hospital)

OTHER EXPERIENCE

2006 Organizing committee for Infectious Disease Course 2006 (Perak State) 2007 Chief Organiser for MRCP PACES Mock Examination in Taiping Hospital 2007 Committee member Malaysian Diabetes Association (Taiping) 2007 Committee member for Innovasion Taskforce of Taiping Hospital 2007-2008 Speaker for couses organized by Taiping Hospital and LMS Health Districtand speaker in several public forums 2007-2008 Organiser for several diabetic camps and public forums for the public 2008 Chairperson for the Endocrine Update 2008 (Perak State) 2008- present Vice President of Malaysian Diabetes Association (Taiping) 2009 Vice chairperson National Conference of Respiratory Medicine 2009 2010 Committee member 6th National Geriatric and Psychogeriatric Conference 2011 Committee member 7th National Geriatric Conference 2013 Committee member Malaysia Parkinson’s Disease Conference and DBS Course August 2013 2014 Organising Chairman 10th National Geriatric Conference Ipoh Perak 2015 Committee member of the Annual Scientific Meeting of the Academey of Medicine 2015 Kuala Lumpur Scientific Co-Chairman National Conference of Clinical Research (NCCR) 2015 Penang 2016 Committee member 3rd Malaysian Parkinson & Movement Disorder Teaching course (Co-organize by MDC (Malaysia) and The Movement Disorder Society Asian & Occanian Section)18-19 November 2016 Penang Malaysia Plenary lecture Geriatric Conference Selangor 16 April 2016, Selangor Symposium speaker State Stroke Step Down Conference 23 April 2016 Examiner and tutor for the Premier PACES teaching course and mock exam September 2016, HKL 2017 Presented at GCP certification course – Taiping Hospital Chairperson and Speakers –Public Forum on Diabetes Examiners for the MRCP clinical Exams Observer for the MASTER exams

2018 Presented at GCP certification course- Taiping Hospital, Sri Manjung Hospital, Advanced Medical and Dental Institute (USM), Hospital Seberang Jaya Chairperson – Geriatric Updates – Hospital Taiping Examiners for the MRCP clinical Exams Symposium speaker at the National Geriatric Conference 2018 (Alor Setar)

Updated 01 Feb 2020