Onderzoekschool Oncologie Amsterdam Oncology Graduate School Amsterdam
Annual Report 2013
Address
Oncology Graduate School Amsterdam OOA VU medisch centrum Kamer PK 7Z 182 De Boelelaan 1117 1081 HV Amsterdam phone : 020-4443113 e-mail : [email protected] website : www.ooa-graduateschool.org
Contents
Preface 5
1 Board and organization 9 2 General report 13 3 Educational activities 19 4 PhD research program 25 5 Awards 49
Annex 1 Faculty and staff 53 Annex 2 International visitors 67 Annex 3 PhD theses completed 71 Annex 4 Scientific publications 81
Oncology Graduate School Amsterdam OOA
preface
Preface
An important mission of the Oncology Graduate activities, including specialized training courses, School Amsterdam (Onderzoekschool Oncologie seminars and meet-the-expert sessions. Besides Amsterdam – OOA) is to organize the education in this, major effort is put into the organization of an basic and clinical cancer research of the graduate annual graduate student retreat. This retreat students in the Amsterdam region, and to ensure teaches skills in reporting, presenting and proper supervision and mentoring of graduate collaboration activities. students. The OOA graduate students are scientist- in-training who receive additional theoretical and This report presents the activities and scientific practical education on various subjects related to output of OOA in 2013. It includes detailed listings cancer. of our educational activities, such as training programs, and an overview of the scientific output, OOA is a joint venture of the medical faculties the including listings of PhD theses completed and VU University Medical Center (VUmc) and the scientific papers published throughout 2013. Academic Medical Center (AMC), of the VU University Amsterdam (Vrije Universiteit - VU) and the University of Amsterdam (Universiteit van Amsterdam- UvA), respectively, and the Netherlands Cancer Institute (Nederlands Kanker Instituut - NKI). These organizations strive for excellence in research and education in oncology, the realization of which is promoted by their participation in OOA.
The OOA research program ranges from basic molecular biology to clinical bedside research. It includes, for instance, fundamental studies on cellular signal transduction and the control of gene Executive Directors, expression, but also clinical trials of new (combination) approaches and the development of Prof. dr. A.W. Griffioen (VUMC) new tools to evaluate the quality of life in cancer Prof. dr. T.K. Sixma and prof. dr. H. te Riele (NKI) patients. OOA organizes a range of educational Dr. M. Spaargaren (UvA)
Preface - 7
8 - Preface Oncology Graduate School Amsterdam OOA
board and organization 1
1. Board and organization
Board Participating institutes
Prof.dr. A. Berns, chairman VU University Amsterdam (VU)/ Prof.dr. S. Rodenhuis VU University Medical Center (VUmc) Prof.dr. C.J.L.M. Meijer Administrative center Prof.dr. P. Postmus Contact / secretariat: dr. E.M. Ruhé-Hoogervorst Prof.dr. C.E.E. Konings De Boelelaan 1117 Prof.dr. D.J. Richel 1081 HV Amsterdam phone : 020-4443113 fax : 020-4442964 Executive directors email : [email protected]
Prof. dr. A.W. Griffioen, chairman University of Amsterdam (UvA)/ Prof. dr. T.K. Sixma till November 2013, prof. dr. Academic Medical Center (AMC) H. te Riele from November 2013 Meibergdreef 15 Dr. M. Spaargaren 1105 AZ Amsterdam phone : 020-5668502 fax : 020-5669165
Netherlands Cancer Institute (NKI) Contact / secretariat: Ms. P. Lagerweij Plesmanlaan 121 1066 CX Amsterdam phone : 020-512 6973 fax : 020-512 1944 email : [email protected]
Faculty and staff
The complete list of founding institutes’ faculty and staff involved in educational activities and research projects conducted by OOA is provided in Annex 1.
Board and organization - 11
12 – Board and organization Oncology Graduate School Amsterdam OOA
general report 2
2. General report
Educational activities understanding of tumor development, progression and therapy resistance. Candidate markers are The OOA is a successful and large graduate school, tested for their ability to predict/detect cancer at with 507 PhD students, 117 faculty members an early stage. Disease profiling is being improved involved. It is the only Dutch research school using innovative research tools. Tools applied in specifically focusing on training in cancer research. research projects include high-throughput methods Monitoring of the quality of research in the for (epi)genetic, transcriptomic and proteomic different institutes is performed by local analyses. Examples are large tumor cohort screens committees at the participating institutes, e.g. a with CGH or expression arrays, gain-of-function research institute or board. genetic screens with retroviral cDNA expression The quality of the OOA is shown by its regular libraries, and loss-of-function genetic screens with accreditation by the Royal Netherlands Academy of RNA interference libraries. Quantitative mass Sciences regularly, currently for the period 2009- spectrometry is being used to search for proteins 2014. to distinguish the diseased and disease-free states. Mechanistic studies using e.g. structural biology The core activity of OOA is training PhD students in complement the functional studies. Advanced conducting cancer research. For this purpose, OOA mouse models or sophisticated xenotransplant has developed a high-quality curriculum. In 2013, models have been developed for the genetic OOA organized various graduate training courses dissection of cancer. At cellular level, processes and an Annual Graduate Student Retreat. like cell-cell communication, adhesion, migration, survival, proliferation and differentiation are all All courses were evaluated by means of being studied. Furthermore, the mechanisms of standardized evaluation procedures. In this way, therapy resistance and metastasis are being OOA carefully monitors the quality of its courses. investigated. Based on the outcome of these evaluations, the Viral oncogenesis projects focus on the role of training programs are being improved continuously. human papilloma viruses and Epstein-Barr virus in the development of human cancer, by using both in A detailed description of all training courses vitro models and clinically well-defined patient offered in 2013 is provided in chapter 3 of this tumor samples. Viral and host markers are being Annual Report. tested for their capability to assess the risk associated with the development of cancer.
Research program Theme 2: Experimental clinical Research projects at OOA’s institutes can be research clustered under two main themes. The theme Improvements in clinical care in oncology are 'Experimental biology' covers 'Oncogenesis' and based on improved detection, development of 'Tumor cell biology' as the main lines of research. innovative therapies and personalized treatment The second main theme is 'Experimental clinical strategies. The emerging and rapidly growing fields research' and covers 'Diagnosis of cancer' and of molecular imaging and genomics are providing 'Prevention and therapy of cancer'. Chapter 4 new opportunities to study the biology of a provides listings of all individual PhD projects malignancy in individual patients and thus allowing conducted within these main themes. More for the development of highly valuable indicators detailed descriptions of these research programs for diagnosis and prediction of disease outcome. and their output are provided in the annual reports The development of the 70-gene breast cancer of the founding institutes. predictor at the NKI has led to the first FDA- approved diagnostic screen for breast cancer. Modern state-of-the-art techniques like MRI, Theme 1: Experimental biology SPECT, PET and PET/CT are enabling imaging The transformation of a normal cell into a methods with high precision and unique molecular malignant tumor cell requires multiple (epi)genetic and biological information at the tissue level. alterations affecting genes that control cellular (Molecular) reporter probes are being developed pathways. Studying the genes and proteins and evaluated. Highly developed mouse models are involved in these pathways results in better being used to follow drug sensitivity in several
General report - 15 types of cancer and for developing clinical OOA has an excellent (inter)national status, as strategies for imaging. Targeted cancer therapy is demonstrated by the large number of research yet another research focus. Personalized therapy projects granted in open national and international should ensure optimal treatment benefits. Projects calls, including several of the prestigious new include (pre)clinical evaluations of the use of grants. The faculty is strongly represented in the neoadjuvant treatment or the application of new ‘vernieuwingsimpuls’, the Veni-Vidi-Vici molecular therapies and anti-angiogenic agents development grants for junior researchers and against novel targets in tumor and its environment. participates widely in CTMM projects and TI The pharmacological optimization of conventional Pharma projects as well as in numerous EU cytotoxic drugs is an important line of research, as integrated projects and networks of excellence. is the passage of drugs through the blood-brain Funding is also strongly supported by the Dutch barrier. Development of immunotherapies based on science foundation NWO and the cancer society, adoptive transfer and vaccination strategies are at KWF. the forefront of research. These, as well as novel targeted (anti-angiogenic) therapies and gene therapy strategies are being developed and tested in clinical trials. Another important clinical Research highlights research theme is quality of life for childhood and adult patients with cancer. Our research highlights included work of Lucas Jae in the group of Thijn Brummelkamp identified new genes involved in the entry of Lassa virus, a virus that causes lethal hemorrhagic fever. PhD projects and students In collaboration with Hans van Bokhoven (Radboud Universiteit Nijmegen) they showed that mutations Overall, 507 PhD projects were actively elaborated in several of these genes leads to familial Walker- throughout 2013. The names of the PhD students at Warburg Syndrome, a disease characterized by the three OOA institutes and the projects in which inappropriate glycosylation of alpha-dystroglycan they participated are listed in chapter 4. (Science 2013;340(6131):479-83). Of all PhD projects, 18% was funded by the Joanna Kaplon in the group of Daniel Peeper has participating institutes themselves (primary shown that oncogene-induced senescence, a key funding; ‘eerste geldstroom'); 17% was financed by mechanism protecting against cancer, is public funds (secondary funding; 'tweede accompanied by an increase in oxidative geldstroom'), 40% by research contracts from metabolism of glucose through suppression of external organisations including cancer charity and pyruvate dehydrogenase kinase (PDK1). She industrial funds (tertiary funding; ‘derde uncovered that inhibition of PDK1 causes geldstroom’) and 25% was financed by other funds regression of established melanomas, highlighting (quaternary funding; 'vierde geldstroom'). PDK1 as a potential target in cancer treatment (Nature 2013;498(7452):109-12). A total of 60 PhD students completed and Nicole Krekel found that ultrasound-guided defended their PhD thesis in 2013. Annex 3 surgery can, compared with palpation-guided provides the complete list of PhD students who surgery, significantly lower the proportion of obtained their degree in 2013 with details of their tumour-involved resection margins, thus reducing theses and graduation. the need for re-excision, mastectomy, and radiotherapy boost. By achieving optimum resection volumes, ultrasound-guided surgery International visitors reduces unnecessary resection of healthy breast tissue and could contribute to improved cosmetic Training of PhD students can be stimulated and results and quality of life (Lancet Oncol 2013;14: enhanced by having scientific interactions between 48-54). students and foreign experts operating in the field Carlos Melo and Jarno Drost in the group of of the students’ research projects. OOA is part of a Reuven Agami studied the role of enhancer RNAs in large international network of cancer researchers controlling gene expression and in cancer. They and, therefore, international guests from other demonstrated that the tumor suppressor p53 binds research institutes visit OOA’s institutes frequently enhancer domains and activates the expression of to interact with OOA students and staff. enhancer RNAs. Intriguingly, those enhancer RNAs Throughout 2013, we welcomed 65 international are key players in the tumor suppressor function of experts in various settings (Annex 2). p53 (Mol Cell. 2013;49(3):524-35). Laparascopic surgery as an alternative to open surgery in patients with rectal cancer has not yet Awards been shown to be oncologically safe. The aim of the Colorectal cancer Laparoscopic or Open Several PhD students and staff of the OOA Resection (COLOR II) trial was to compare institutes won prestigious awards and honors – laparoscopic and open surgery in patients with scientific or otherwise – in 2013. Chapter 5 rectal cancer. Martijn van der Pas of the research provides a listing of these awards and honours. group of Jaap Bonjer found that selected patients with rectal cancer treated by skelled surgeons, laaroscopic surgery resultend in similar safety,
16 - General report resection margins, and completeness of resection to that of open surgery, and recovery was A total of 1908 papers have been published by improved after laparoscopic surgery (Lancet Oncol. researchers from the three institutes. Of these, 2013;14(3):210-8) 103 papers concerned collaborations between Felipe de Sousa E Melo et al demonstrated, using researchers from VUmc, NKI and AMC. Annex 4 an unsupervised classification strategy involving provides the complete list of scientific publications over 1,100 individuals with colon cancer, that three in 2013. main molecularly distinct subtypes can be recognized. Two subtypes have been previously identified and are well characterized. The third subtype is largely microsatellite stable and contains Facilities relatively more CpG island methylator phenotype- positive carcinomas but cannot be identified on the The main goal of all research activities of the 3 basis of characteristic mutations. The identification OOA institutes is to better understand the of this subtype is crucial, as it has a very development of cancer and to improve the unfavorable prognosis and, moreover, is refractory perspectives of cancer patients. For this purpose, to epidermal growth factor receptor-targeted many state-of-the-art technologies are present and therapy. (Nature Med.2013;19(5):614-618) new initiatives have been developed. Information Monique Terwijn et al studied the value of about innovative technologies is communicated at immunophenotypically assessed minimal residual many occasions, including courses and the OOA disease (MRD) in the context of a multicentre retreat, and these technologies are open to PhD clinical trial in adult acute myeloid leukemia with students within OOA. As a result, the OOA PhD sample collection and analysis performed in a few students often have early access to novel specialized centers. They concluded that in future techniques and can apply these in research. treatment studies, reisk stratification should be based not only on risk estimation assessed at State-of-the-art facilities are: diagnosis but also on MRD as a treapy-dependent * Animal Pathology and Histoplogy Facility (NKI) prognostic factor (J Clin Oncol. 2013;31(31):3889- * Chemical Screening Facility (NKI) 97). * Core Facility Molecular Pathology and Biobanking Louis Vermeulen et al quantified the competitive (NKI) advantage of Apc loss, Kras activation, and P53 * Cryogenic Storage (NKI) mutations in the mouse intestine. Their findings * Mouse Intervention Facility (NKI) indicate that the fate conferred by these * Peptide Synthesis Facility (NKI) mutations is not deterministic, and many mutated * Proteomics Facility (NKI) stem cells are replaced by wild-type stem cells * Radionuclide Centre (NKI) after biased, but still stochastic events. * Deep sequencing facility (NKI, AMC) Furthermore, P53 mutations display a condition- * Microarray facilities with high resolution dependent advantage, and especially in colitis- oligonucleotide array and CGH arrays for mouse affected intestines, clones harboring mutations in and human studies (VUmc, NKI, UvA) this gene are favored. This work confirms the * Oncoproteomics laboratory for protein and glycan previously theoretical notion that the tissue profiling using mass spectrometry (VUmc, AMC) architecture of the intestine suppresses the * (Molecular) Imaging facilities (cyclotrons, GMP accumulation of mutated lineages (Science facilities, animal and clinical PET/CT-cameras and 2013;342:995-998). MRI-machines) enabling imaging of anatomical Novel endoscopic technologies could allow optical details with high precision (VUmc) diagnosis and resection of colonic polyps without * Tissue microarray facility (VUmc, AMC) histopathological testing. The aim of the study of * Robotics and screening facility, including high Linda Wanders et al was to establish the content imaging (NKI) sensitivity, specificity, and real-time negative * Microscopy facility, including extensive confocal predictive value of three types of narrowed and electron microscopy (NKI, AMC) spectrum endoscopy (narrow-band imaging [NBI], * (Flow) cytometry facilities - Coulter, BD, Acumen image-enhanced endoscopy [i-scan], and Fujinon (NKI, AMC, VUmc) intelligent chromoendoscopy [FICE]), confocal laser * Extensive animal facilities (NKI, AMC) endomicroscopy (CLE), and autofluorescence * Imaging facilities, microPET, MRI, SPECT (VUMC, imaging for differentiation between neoplastic and NKI, AMC) non-neoplastic colonic lesions. Based on their * Radiotherapy facilities (NKI, VUMC) findings, they stated that endoscopic imaging * Tissue and Serum biobanks (NKI, VUmc) techniques other than autofluorescence imaging * Genomics: MPS GS-FLEX sequencer (AMC) could be used by appropriately trained * Lentiviral library for RNA-silencing for human and endoscopists to make a reliable optical diagnosis mouse (AMC) for colonic lesions in daily practice. Further * Mass spectrometry facility (NKI, VUmc, AMC) research should be focused on whether training * Protein expression and purification facility (NKI) could help to improve negative predictive values (Lancet Oncol.2013;14:1337-1347). In addition, new initiatives are:
General report - 17
* Imaging Center (including training center) (VUmc) * Central Clinical Trial Support (office) (VUmc, AMC) * Phase I/II unit for clinical trials (VUmc, AMC) * Biobanking (VUmc, AMC) * Human monoclonal antibody phage display facility (VUmc) * Mouse Clinic (NKI) * Research IT (NKI)
18 - General report Oncology Graduate School Amsterdam OOA
educational activities 3
3. Educational activities
In line with its mission, i.e. providing graduate variables. This OOA course provided introductory students education in oncology research, OOA hands-on training in histopathology of tumors. The organizes several advanced courses in the field of course aimed to provide better insight in the oncology annually. The educational program is histopathology of various tumor types, in relation drawn up by the Board of Directors based upon to diagnostic, prognostic and therapeutic evaluations of previous courses, contemporary significance. As the course includes an introductory developments in cancer research, and educational session, only basic knowledge on histology is needs expressed by PhD students as well as required. initiatives from the OOA faculty. OOA offers The Histopathology of Human Tumors course courses focused on a wide variety of topics. comprised hands-on sessions using scanned slides, plenary expert talks and multihead microscopy In 2013, 7 courses and 2 Meet-the-Expert sessions sessions. were organized. In addition, the Annual Graduate Student Retreat was organized again in 2013. A total number of 17 PhD students participated in Courses are usually restricted to about 15-20 the course. graduate students to ensure optimal interaction The overall evaluation rate was 4.3 (scale 1-5). between students and faculty. Courses are advertised on the OOA website and announced by e-mail to the PhD students. How to write High Impact papers and Courses included lectures given by (inter)national experts, demonstrations and practical training. what to do when it is rejected Organization: dr. M. van der Linden Besides the specialized oncological courses Date: February 25 and March 4 mentioned below, the graduate students followed Location: VUmc several general courses such as on biostatistics and epidemiology, on laboratory animal technology and Scientific writing is undergoing dramatic changes. on writing and (poster)presentations techniques in Many papers are rejected without being sent for scientific English. These courses were organized by peer review and yet other papers appear on the AMC, VUmc and NKI. PubMed within weeks of submission. This workshop introduced strategies for writing journal articles so that the process may not be effortless and joyous,
but at least less painful and more assured of Histopathology of tumors success. Organization: dr. K. Grünberg Topics included creative means of using electronic Date: January 30-31 resources, cultivating collaborations, building Location: VUmc writing into your life style, writing and rewriting the manuscript, getting your manuscript past the Aim of this course was to give an introduction in editor and sent out for peer review, postsubmission the histology of malignant tumors and their responsibilities, and using publicity to increase precursor lesions. Microscopical structures, growth early citations. patterns, grading and staging systems, and different cell types present in selected tumor A total number of 34 PhD students participated in types were explained and discussed by the course (2 classes). pathologists. The overall evaluation rate was 4.0 (scale 1-5).
Many research projects focus on tumor biology in order to predict survival or therapy response, using DNA-, RNA- or protein-based tests. Also, Cytoskeleton in the control of cell understanding biological mechanisms of a tumor migration may reveal new targets for future treatment. Organization: Dr. M. Innocenti, While many PhD students in cancer research Dr. A. Sonnenberg nowadays have a background in molecular biology, Date: March 4 -15 few are well acquainted with histological Location: NKI characteristics of tumors, and the clinical significance of histopathological findings. In daily The cytoskeleton is a protein scaffold controlling clinical practice histopathological examination of the shape, the division and the movement of cells tissue is the mainstay and gold standard of a and their internal components. The dynamic cancer diagnosis. In addition, the choice of remodeling of the cytoskeleton is crucial for the treatment largely depends on pathological
Educational activities - 21
proper execution of many developmental and Dr. Colin Watts is a senior lecturer and homeostatic programs. neurosurgeon at the department of Clinical Neurosciences at Cambridge University, UK. His Deregulation of cytoskeletal dynamics can cause lab-based research is focused on the genomics of diseases and pathologies, including metastasis of glioblastoma (GBM) and the role of glial cancer cells. This course focused on how actin and progenitors in their evolution and development. In microtubules control cell motility in health and addition he has developed patient-specific models disease. of GBM to evaluate intra-tumour variability in genomic and clonal architecture. A total number of 15 PhD students participated in This meet-the-expert session was proceeded by the the course. The overall evaluation rate was 8.3 LWNOi-symposium “Heterogeneity in Malignant (scale 1-10). Glioma”.
A total number of 8 PhD students participated in The Microscopic, Macroscopic and the course. The overall evaluation rate was 4.2 Pathologic Anatomy of the Mouse (scale 1-5). Organization: Prof.dr. W. H. Lamers Dr. E. Wierenga Antibody-(in)-dependent assay Date: April 8-11 development Location: AMC Meet-the-Expert with Prof. Dr. F. Pontén
Most biomedical PhD students perform animal and Prof. Dr. R. Aebersold experiments at some stage of their research Organization: dr. R. Fijneman career, but most students have never received Dr. C. Jimenez practical instructions with respect to the anatomy, Date: October 4 histology and pathological anatomy of Location: VUmc experimental animals. For this reason, experimental animals are usually not subjected to Prof. Fredrik Ponten heads the Human Protein a thorough and systematic inspection to assess Atlas effort at the Uppsala site. The HPR project whether, besides the local (expected) effects in involves a large-scale effort to do antibody-based the organ(s) under study, other organs are affected human tissue proteomics. The aim of this project is as well. to generate specific antibodies towards human This annual course aims at providing insight(s) into gene products and to use these to map expression the anatomy and histology of the mouse, presently in human tissues and cells. All antibodies are the most frequently used animal species in cancer screened on > 700 spots including approx. 50 research. In addition, the course focused on the normal tissues, 20 common forms of cancer and 50 recognition of pathological changes in the mouse. cell lines. All immunostained spots are scanned to During the course each student dissected either a produce high-quality images. All data is stored in a male or a female mouse, to become acquainted web-based which is publically available. with the topographic anatomy of this species. The Prof. Ruedi Aebersold is one of the pioneers in the microscopy part of the course focused on studying field of proteomics. He is known for developing a the architecture of normal and pathologically series of methods for quantitative mass altered mouse tissues. During the practical part, spectrometry. He and his team of researchers use recognition of cell and tissue types, and changes in the protein profiles determined by this method to architecture of tissues as a result of pathological differentiate cells in different states, such as processes, were studied microscopically. noncancerous versus cancerous cells, and to In addition to standard staining techniques, systematically study how cells respond to external functional staining techniques were demonstrated. stimuli. These "snapshot" profiles indicate which This year the practical part of the microscopical cells contain abnormal levels of certain proteins. anatomy has been done with computerized This is expected to lead to new diagnostic markers sections and computer assisted magnifications. for disease and to a more complete understanding of the biochemical processes that control and A total number of 20 PhD students and 4 Master constitute cell physiology. Oncology students participated in the course. The overall evaluation rate was 7.4 (scale 1-10). A total number of 7 PhD students participated in the course. The overall evaluation rate was 4.3 (scale 1-5). The role of the ecosystem in cancer and intratumoral heterogeneity Meet-the-Expert with dr. C. Watts Basic Microscopy Course “In the Organization: drs. H. van Thuijl Footsteps of Antoni van Leeuwenhoek” Date: September 12 Organization: Dr. J.A.M. Beliën Location: VUmc Dr. L. Brocks Dr. L. Oomen Prof.dr. P. Peters
22 – Educational activities
Dr. E.A.J. Reits an introduction into design aspects, methods of Dr. N van de Wel summarizing and presenting data, estimation, Time: October 7-11 confidence intervals and hypothesis testing, Location: VUmc/AMC/NKI including multivariable regression methods for the assessment of association. Although the course This 5-day basic course covered a wide range of focusses somewhat on methods and examples from aspects of microscopy, starting with a short history clinical research, it should be useful for of microscopy and basic principles of various forms experimental researchers as well. The emphasis of microscopy. Lectures, hands-on sessions covered will be on practical application and interpretation the basics of image analysis and image processing, rather than theory. image measurement, electron microscopy, confocal microscopy and imaging (live cell A total of 52 PhD students participated in the imaging), fluorescence microscopy (time-lapse course. imaging and deconvultion) and correlative light The overall rating was 8.1 (scale 1-10). and electron microscopy. During the course samples were prepared and examined. The Early detection of cancer: molecular participants could bring their own purified proteins tools and new developments solutions after consulting with the organization Organization: Dr. B. Carvalho first. Dr. D. Heidemans
Date: December 9-10 A total number of 16 students participated in the Location: VUmc course. The overall evaluation rate was 4.8 (scale
1-5). A promising strategy to reduce the mortality from cancer is the detection and treatment of the disease at an earlier, localized stage. When cancer Annual Graduate Student Retreat is diagnosed at an early stage, the treatment is Organization: Prof.dr. T.K. Sixma often simpler and more likely to be effective. So, P. Lagerweij finding cancer early can make a real difference for Drs. C. Kapper the prognosis of the patient. Time: October 23-25 Early detection of cancer can be performed Location: Renesse effectively by screening. Screening refers to the use of simple tests across a healthy or at risk A highlight of the educational program is the population in order to identify individuals who Annual Graduate Student Retreat. This three-day have disease, but not yet symptoms. An intriguing retreat focuses entirely on research conducted by example is cervical cancer screening using cytology the graduate students themselves. At the retreat, (Pap smear). During this course, we addressed students not only present their work as a poster in general aspects of screening, its pro’s and con’s the first year of their participation and as an oral and focus on recent advances in molecular tools presentation in subsequent years, they are also in for early detection. Research and technical charge of chairing sessions and discussions. developments in the field of lung, prostate, In recent years, student participated in peer colorectal and cervical cancer were discussed. review of the presentation given by others in order to award the prize for the best poster and best A total of 22 PhD students participated in the presentation. In this manner, the retreat trains course. important skills in presentation and interaction but The overall rating was 3.9 (scale 1-5). it also provides an overview of research conducted within OOA at a early stage of the student’s career, contributing significantly to the interaction between different groups: clinical and fundamental students. The location Hotel Opduin on the island of Texel reached its maximum capacity. This year the retreat was organized in Ermelo.
A total of 138 students participated in this retreat. The overall evaluation rate was 4.2 (scale 1-5).
Basic Medical Statistics
Organization: Dr. M. Hauptman
Date: November 25-29
Location: NKI
This 5-day course explained statistical techniques for the evaluation of biomedical data. It provided
Educational activities - 23
24 – Educational activities Oncology Graduate School Amsterdam OOA
PhD research program 4
4. PhD research program This chapter describes the 507 PhD projects conducted within the two main themes of the OOA research programs, with the names of the PhD students involved and their supervisor(s). * PhD students who obtained their PhD degree in 2013 # PhD students who stopped their PhD research in 2013
Funding 1 Financed by participating OOA institute (“eerste geldstroom”) 2 Financed by public funds (“tweede geldstroom”) 3-4 Financed by private funds (“derde / vierde geldstroom”)
Theme 1: Experimental Biology
Name Title of Project Supervisor Start Fund Biochemistry (NKI) Blomen V. Functional Profiling of a Human knockout collection Brummelkamp 2010 1 Dharadhar, S. Structural studies of regulation of ubiquitin conjugation and Sixma 2013 4 deconjugation Groothuizen F. Structural studies of DNA mismatch repair Sixma 2009 2 Hausmann J.* Structural studies of autotaxin Perrakis 2008 4 Jae L. Identification of genes that play a role in human disease Brummelkamp 2011 1 Kim R. Regulation of the Usp7/HAUSP switch Sixma 2012 3 Mattiroli F.* Structural and functional analysis of novel E3 ubiquitin Sixma 2006 2 ligase consisting of polycomb proteins BMl1 and Ring 1B Nieuwenhuis J. Tissue control and the regulation of Hippo pathway activity Brummelkamp 2012 4 in mammals Sahtoe D. Ubiquitin structure and function Sixma 2009 2 Smit J.J.* Ubiquitin conjugation Sixma 2007 4 Staring J. Tissue size control and the regulation of Hippo pathway Brummelkamp 2010 4 activity in mammals Uckelmann M. The balance of ubiquitin conjugation and deconjugation Sixma 2011 4 Biological Stress Response (NKI) Buoninfante, A. Exploring DNA-damage tolerance as a drug-target for Jacobs 2013 3 chemosensitization and a mechanism of chemoresistence Harmsen T. Oligonucleotide-directed gene modification in human Te Riele 2011 4 induced pluriipotent stem cells Harn van T.* Role of the G2 restriction point in tumor development and Te Riele 2007 3 behaviour Hogenbirk M.* A Cancer Genome Atlas of the activation induced cytidine Jacobs 2008 3 deaminase novel insights into the pathogenesis and prognosis of B cell lymphoma Houlleberghs H. Characterisation of unclassified allelic variants of DNA Te Riele 2010 4 mismatch repair genes to improve genetic counceling Krijger de, I. A critical role for EHSC1 at telomeres Jacobs 2012 2 Rooswinkel R.* Improvement of chemoradiotherapy in head and neck Verheij 2008 3 cancer by small molecule inhibitors of Bcl-2
PhD research program - 27
Seeman I. The role of endoglin in induction and repair of Stewart 2008 3 cardiovascular damage after radiation alone or in combination with trast Wit N.* A cancer Genome Atlas of the activation induced cytidine Jacobs 2008 3 deaminase Wielders E.# Subtle gene modification to study the role of the mismatch Te Riele 2004 3 repair complex Msh2/Msh5 in mutation avoid Cell Biology I (NKI) Boekhout M. Spindle Checkpoint independent control of the APC/C Wolthuis 2010 4 Clijsters L. Targeting protein destriction during cell division Bernards 2007 3 Elbatsh A. Dissecting the prophase pathway of cohersin removal Medema 2012 Ellenbroek S.* Tiam1/Rac signaling and wnt/beta-catenin-induced Collard 2004 3 tumorigenicity Elouarrat D.* Regulation of sirt1 and downstream targets by Moolenaar 2005 4 phosphoinositides Feringa F. Spontaneous recovery after DNA damage Medema 2011 4 Kedziora K. Calcium and phosphoinositides in the control of podosome Jalink 2010 3 formation and tumor cell invasion Leyton Puig D. Super-resolution Microscopy (Nanoscopy): From sharp Jalink 2011 4 images towards imaging of molecular interaction Margadant C.* Generation of a mouse model for EBS-MD Sonnenberg 2006 4 Nahidi Azar L. Super-resolution Microscopy("Nanoscopy"): From sharp Jalink 2011 4 images towards imaging of molecular interaction Sachs N.* Function of integrin-CD151 complexes in tumor cell invasion Sonnenberg 2004 3 and metastasis Veen, van M. Autotaxin and GDE2: functional and structural analyses Moolenaar 2011 2 Visser D. TRPM7 a novel regulator of cytoskeletal tension Jalink 2007 3 implications for cancer progression, invasion and metastasis Voets E. Divergent control of Cyclin B1-Cdki in cancer cells: a key role Wolthuis 2008 3 in therapy Cell Biology II (NKI) Afanasyev P. Analysis of 3D structure of molecular machines with cryo- Peters 2011 4 electron omography using novel nanochambers Bakker J. Towards understanding and manipulation of MHC class II Neefjes 2010 4 antigen presentation Deventer, van S. Kinome and phosphatome knock-down Neefjes 2008 2 Ekkebus R. Pan DUB inhibitors to study the ubiquitinated proteome Ovaa 2009 2 Hoppes R. Characterization of peptide-MHC interactions Ovaa 2007 2 Jong de A. Post-Translational transpeptidation and immunity Ovaa 2009 2 Jongsma M. Manipulating the MHC class II system to control immune Neefjes 2007 2 responses in auto immunity Kant van der R.* Manipulating the MHC class II system to control immune Neefjes 2007 2 responses in auto immunity Leestemaker Y. Proteasome activation Ovaa 2011 1 Luimstra J. Mass cytometry staining agents for combinattorial MHV- Ovaa 2012 1 exchange Tcell coding Pang B.* Manipulation of phagosomal pathways Neefjes 2006 2
28 – PhD research program
Schunselaar L. Drug responses with primary cultures of tumor cells from Neefjes/Baas 2012 1 mesothelioma patients Shahul Hameed S. Engineering Ubiquitin Related Proteins to Reveal their Ovaa 2009 4 Function Tilburg van, G. Decoding the ubiquitin code Ovaa 2013 4 Wijdeven R. Towards underfunding and manipulation of MKC clan II Neefjes 2009 1 antigen presentation Witting K. UPStream Ovaa 2012 4 Wu L.# Towards underfunding and manipulation of MHC clan II Neefjes 2010 4 antigen presentation Gene regulation (NKI) Brinkman E. Nuclear lamins and chromosome organization Van Steensel 2012 4 Brueckner, L. Mechanisms that determine chromatin composition Van Steensel 2013 2 Chen T. Principles of chromatin organization Van Steensel 2012 4 Han, R. Genomewide identification of cancer induced alterative in Agami 2013 1 protein translation Korthout, T. Principles of Epigenetic Inheritance Van Leeuwen 2013 2 Lopes R. Identification of Mirnas regulatory mechanismus in cancer Agami 2011 4 Melo C. mcRNA’s and cancer Agami 2009 4 Porambo, D. Principles of Epigenetic Inheritance Van Leeuwen 2013 2 Rooijers K. Analysis of ribosome profiling data Agami 2011 4 Terweij M.* Chromatin dynamics and epigenetic changes Van Leeuwen 2009 4 Vlaming H. Role of histone mthyltransferase Dot1 in gene expression Van Leeuwen 2010 2 and leukemic transformation Wilting R.* The role of class I HOACs in normal physiology Dannenberg 2009 3 tumorigenesis and transcriptional regulation Immunology (NKI) Ahrends, T. Exploring the nature of CD4 T cell-help for the CS8 T-cell Borst 2013 3 response to optimize immunotherapy of cancer Ariotti S. Introvital imaging of epidermal imunne phenomene in virus Haanen 2007 1 infections and DNA tattooing Babala, N. Contribution of costimulatory receptors to Borst 2013 3 immunosuppression versus immune activation Buuren van M. The use of MHC-tetramer technology to characterize HCV Schumacher 2010 4 specific T-cell responces Ciampricotti M. The inflammatory tumor microenvironment and its impact De Visser 2009 2 on signal cancer development and therapy Deken M. Combining ragerted therapy and immunotherapy Blank 2012 2 Dijkgraaf F. Intravital imaging and computational ignallin of skin Schumacher 2012 4 immunity Doornebal C. The role of cancer cell-interinsic and microenv. Factors De Visser 2009 1 contr. To metastasis formation and its modulatation by opioid Fanchi, L. mmunotherapy of cancer through TCR gene transfer Schumacher 2012 Hooijkaas A.* Generation of melanoma-specific immune responses Blank 2012 4 Kelderman S. Development of adoptive T-cell therapies Schumacher 2009 1
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Kersten K. Cancer cell-intrinsice and-extrinsic regulation of breast De Visser 2011 2 cancer metastais formation, implications for adjuvant therapy Kok, L. Single cell tracing within the T cell lineage Schumacher 2013 4 Kooij van de B. A novel type of ubiguintination regulates apoptosis Borst 2008 2 signalling by BH3 only protein Bid Linnemann C.* Preclicinal development of TLR gene therapy for prostate Schumacher 2008 2 carcinoma Mezzadra R. Development of TCR1Ano vector 1 items for TCR gene Schumacher 2010 2 therapy Veraar E. TNF ligands in cancer: CD70 Borst 2006 4 Molecular Oncology (NKI) Barazas, M. Tumor Heterogeneity and Therapy excape mechanisms in Rottenberg 2013 2 genetically engiNOred mouse models for breast Boersma, V. Genome-wide identification of factors controlling the Jacobs 2012 4 telomere damage response and telomere-driven genomic instabillity Durmus S. The impact of ABC transporters on carcinogen resistance Schinkel 2009 1 Gogola E. Resistance to PARP inhibition by DNA damage response Rottenberg/Jonkers 2012 3 alterations Huang, X. Dissecting the essential contribution of FRA-1 to human Peeper 2013 2 tumor cell metastasis Iskit S. Dissecting the essential contribution of FRA-1 to human Peeper 2009 4 tumor cell metastasis Iusuf D.* OATP1A/1B(SLCO1A/1B) drug uptake transporters in Schinkel 2008 3 anticancer drug pharmacokinetics and toxicity risks; possible strategy Kaplon J. The relationship between cell metabolism, sencescence and Peeper 2007 2 cancer Peuscher M.* Novel factors involved in chromosome END protection by Jacobs 2007 3 telomeres Tang S.C. * Impact of apical ABC transporters and cytochrome P450 3A Schinkel 2009 4 and novel tyrosine kinase inhibitor anticancer drugs Torre van der J. Novel factors involved in chromosome end protection by Jacohs 2006 3 telomeres Xu G. Selective targeting of DNA damage response to eradicate. P. Borst 2009 3 HR-deficient tumors Yalcin, Z. How ubiquitiniation controlos telomere-induced genomic J.Jacobs 2012 3 instability Zander S.* Mechanisms of chemotherapy resistance of spontaneous P. Borst 2007 2 mammary tumors in genetically-engineerd mouse models Molecular Carcinogenesis (NKI) Bismeijer, T. Multi level models to prevent overtreatment Wessels 2013 4 Brunen D. Finding genetic dependencies in cancer: the missing link in Bernards 2012 3 personalized medicine Dyk van E. Modularity and Complex Interaction in Cancer Wessels 2009 2 Groenendijk F. ERC functional genomics Bernards 2010 4 Heynen G. Determinants of the breast cancer stem cell phenotypes Bernards 2008 2
30 – PhD research program
Jong de J. Modularity and Complex Interaction in Cancer Wessels Lint de K. Dissecting genetic dependencies in cancer Bernards 2010 4 Prahallad A. Coltheres Bernards 2010 2 Ronde de J.* CTMM - Breastcare Wessels 2008 4 Staiger C.# Subnetwork module construction for imporved diagnostic Wessels 2009 1 classification and subtyping Sun C. Targeting protein destruction during cell division Bernards 2010 4 Sustic, T. Personalized medicine/therapies for lung cancer Bernards 2013 1 Thijssen, B. Computational modeling of cancer Wessels 2013 4 Wang L. Cancer Genomics Center Bernards 2012 4 Molecular Genetics (NKI) Alendar A. Identificaiton of the PIM regulatory network by micro array Berns 2002 3 analysis and high through put retroviral tagging Cioni, B. The Interaction between myoloid cells in the tumor Bergman 2013 2 microenvironment of human prostate cancer on squamer cell carcinoma of the head and neck SCCHW Galen van P. Genetic screening approaches to the characterization of Van Lohuizen 2008 4 human blood and leukemia development Gisler S. Role of Polycomb repressors in reprogramming and breast Van Lohuizen 2011 4 cancer Ikink G. Identification and Characterization of Novel Breast Cancer Hilkens 2010 1 Genes Collaborating with ErbB2 Isogai T. Understanding the role of filopodia in cell migration Innocenti 2009 1 Koppens M. Role of Polycomb repressors in prostate cancer and breast Van Lohuizen 2009 2 cancer models Montfort van E.H.M# Development of a mouse model to study the genetic basis Berns 2000 3 of malignant mesothelioma Velden van der Y.* The role of lkB1 in tissue morphogenesis and cancer Haramis 2005 2 zebrafish Clinical Epidemiology and Biostatistics (VUmc) Wubulikasimu A. Evaluation of classification strategies for colorectral cancer Meijer 2009 1 and 2 Clinical Genetics (VUmc) Adank M.* Breast cancer predisposition Meijers 2007 2 Bakker J.L. Molecular and phenotypic consequences of the Waisfisz 2009 1 CHEK2*1100delC mutation and targeted therapy for breast cancer that lacks CHEK2 Corbin M. Human Genes essential for the defense against oxygen Joenje /Dorsman 2008 3 toxicity Dommering C.J. Retinoblastoom en erfelijkheid Meijers 2006 1 Greuter M. ASCCA (Adenoma and Serrated pathway to Colorectal Coupe 2012 CAncer) Haitjema A. Proteins interacting with FANCI and PALB2 Joenje / Dorsman 2008 3 Massink M. Molecuar classification of familial breast cancer Joenje / Waisfisz 2008 2 Mol B.M. Molecular carcinogenesis of retinoblastoma Dorsman / Cloos 2008 3 Stoepker C. The Fanconi anemial/BRCA pathway in oral squamous cell Joenje 2008 1 carcinomas
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Kooi E.I. Genomics to improve diagnostics and care of te Riele 2011 3 retinoblastoma patients Hematology (VUmc) Leeuw de D.C. Uncovering the molecular pathways (microRNAs) that Smit 2009 3 regulate tumor-initiating potential of Leukemic stem cells Kerkhoff N. Role of immune responses focussing on DC in the Ossenkoppele, van 2012 1 pathogenesis of low and high risk Myelodyplastic de Loosdrecht syndromes: implications for immunotherapy Wojtuszkiewicz A. The role of impared FPGS splicing in methotrexate response Jansen 2010 3 in childhood acute lymphoblastic leukaemia Medical Oncology (VUmc) Hodzic J. Identification of genes involved in resistance of prostate Van Beusechem 2009 3 cancer cells to irradiation Kruger DT PI3K pathway analysis in tumor tissue and circulating DNA Boven E 2013 4 Lameris, R. Targeting of CD1d in Multiple Myeloma de Gruijl 2013 3 Roemer M.G.M. Characterizing genetic alterations in diffuse lage B-cell de Jong 2012 3 lymphomas occuring in immune provileged sites Schneiders F.L. iNKT and Vγ9Vδ-T cell based immunotherapies for solid Van der Vliet 2009 1 tumors Siebring van Olst E. Identification of genes involved in resistance of lung cancer Van Beusechem 2009 3 cells to cisplatin Warmoes M. Proteomics of breast cancer Boven 2007 4 Medical Microbiology and Infection Control (VUmc) Ates L.S. Live mycobacterium bovis BCG bacteria as a platform for Bitter 2011 1 the induction of enhanced tumor-antigen-specific immunity Molecular Cellbiology and Immunology (VUmc) Braster R. Identification of tumor-derived proteins that modulate Beelen 2011 1 macrophage effector functions da Silva Aresta Belo Galectins in tumor progression and tumor immunology Van Kooyk 2009 4 van Wijk A.I. Grewal S. Coelctomy enhances tumor cell adhesion in the liver and van Egmond 2011 2 subsequent outgrowth of metastases Grimwal, S tumor immunology of per cavity mozaiek now Beelen/ Bonjer/ van 2013 2 Egmond Neurology (VUmc) Groot de M.* Correlation between SV2A expression in tumour tissue and Reijneveld 2008 4 efficacy of levetiracetam in glioma patients with epilepsy Rijn van S. Modulation of miRNAs in glioma stem-like cells Würdinger 2009 3 Sewing L. Developing mouse models of diffuse intrinsic pontine Kaspers 2012 3 glioma (DIPG) for pre-clinical research Otolaryngology/ Head and Neck Surgery (VUmc) Graveland A.P. Molecular diagnostis of head and neck squamous cell Brakenhoff 2005 3 carcinoma (HNSCC) Kemp de S.R. Determinants of chemotherapy sensitivity Braakhuis / 2007 1 Brakenhoff Plas van der M. Identification of oncogenic microRNAs and classical cancer Brakenhoff / 2008 3 genes involved in head and neck SSC by a functional Braakhuis genomics approach
32 – PhD research program
Rijken, J.A. SDHB-linked head and neck paragangliomas Hensen / Leemans 2013 3 Pathology (VUmc) Bierkens M.* Genetic profiling of CIN 3 lesions diagnosed in the Snijders / 2007 1 subsequent screening round following screening by HPV Steenbergen testing and cytology Bosch L.J.W.* Methylation for Early Colorectal Cancer Detection Meijer 2005 4 Broek E. van den Structural chromosomal rearrangements in colorectal Meijer 2011 1 cancer Groen F.L.M. de Identification of novel oncogenes/oncomirs located at 13q Meijer 2010 1 involved in the progression of colorectal adenoma to carcinoma Hiemstra A.C. Development of an improved molecular test for population- Meijer 2011 3 wide colorectal cancer screening Mendeville, M Molecular stratification for diffuse large B-cell lymphoma as Ylstra, B 2013 3 a guide for treatment choice. Miok V. Comprehensive molecular characterisation of a longitudinal Snijders 2012 3 in vitro model of high-risk HPV-mediated transformation Rijkaart D.* Stratifying high-risk HPV positive women for risk of CIN 3 Snijders / Meijer 2006 3 and cervical carcinoma by HPV transcript analysis Scheinin A.I. Data mining DNA copy number changes in cancer Meijer 2011 3 Scherpenisse M.* Immunity against Human Papilloma Virus Meijer 2008 3 Thuijl H.F. van Chromosomal aberrations associated with progression Heimans 2010 3 characteristics of low-grade glioma patients Turksma A.* Towards adjuvant immunotherapy for squamous cell Hooijberg / Meijer / 2007 3 carcinoma Leemans Wit de M.* Molecular imaging of colorectal cancer Meijer / Fijneman 2006 4 Paediatrics (VUmc) Wouters R. Clonal evolution of acute myeloid leukemia stem cells Cloos 2012 3 Radiology & Nuclear Medicine (VUmc) Pekosak, A Carbon-11 labeling of peptides Windhorst / Poot 2013 3 Biomedical Engineering and Physics (UvA) Bremmer R. Reflectance Spectroscopy on Ageing Blood Stains Van Leeuwen 2007 2 Bruin de D.M. Reflectance Spectroscopy on Ageing Blood Stains Van Leeuwen 2007 1 Holz J. Luminescence imaging and spectroscopy for early detection Van Leeuwen/ 2010 2 of Barrett’s neoplasia Bergman/ Aalders Swaan A. Spectroscopic biopsy of the prostate Van Leeuwen / de la 2013 2 Rosette Center for Experimental Molecular Medicine (AMC/UvA) Balzarolo M.* Regulation of TRAIL in immune cells Wolkers/ Medema 2008 1 Colak S. Cancer stem cells in colon carcinoma; their flexibility, role in Medema 2008 2 tumor growth and therapy resistance Damhofer H. Pranceatic cancer stem cells Medema / Bijlsma 2010 1 Ebbing E Eosaphageal cancer van Laarhoven 2013 1 Fessler E. Microenvrionmental regulation of CSC Medema 2011 1 Guadagnoli M.* TNF ligands in cancer Medema 2007 3 Lascano V. Cancer stem cells in colon carcinoma; their flexibility, role in Medema 2008 3
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tumor growth and therapy resistance Linnekamp J. Wnt target Methylation in Colorectal Cancer Medema van 2013 2 Laarhoven Oei A. Radiation damage Rasch 2012 3 Potze L. Applicability and mechanism of Betlinic Acid induced tumor Medema 2009 3 killing Prasetyanti P.R. Survival and differentiation of Colon Cancer Stem Cells Medema 2010 3 Shi K. Role of Blood coagulation in pancreatic cancer Richel / Spek 2010 1 Sousa E Melo de F.* Epithelial mesenchymal interaction in colorectal cancer Medema 2008 2 Van der Heijden M. Stem cell biology and cancer Medema 2012 1 Van Oorschot B. Prostate cancer radiation side-effects Medema 2011 3 Veenstra V.* Microenvironment in pancreatic cancer Medema van 2013 3 Laarhoven Zimberlin C.D. Mouse models for colorectal cancer Medema / Bots 2010 1 Clinical chemistry (AMC/UvA) Besancon O.G. Preclinical screening of drug combinations for Caron/ Tytgat/ 2008 3 neuroblastoma Kuilenburg Cuperus R. Modulation of fenretinide induced cell death in Caron / Kuilenburg 2004 neuroblastoma Experimental Hematology and Immunology (AMC/UvA) Attekum, van M.H.A. The role of TNFr-family member APRIL on the proliferation kater/Eldering 2011 1 and survival of CD5+ B-cells in chronic lymphoceutic leukemia Heer de K. Kinetcs and homing of CLL cells Van Oers/ Eldering 2010 Raa te D. Improving Outcome of P53 Dysfunctional Chronic Van Oers/Eldering/ 2010 Lymphocytic Leukemia by Early Detection and Kater Circumvention of the P53 Pathway Schot J.J. The role of TNFr-family member APRIL on the proliferation Van Oers/Eldering/ 2009 3 and survival of CD5+ B-cells in chronic lymphoceutic Kater leukemia Thijssen, R Novel targeted therapies in CLL Kater/Eldering/Kerst 2012 2 and 4 en Gastroenterology (AMC/UvA) Davelaar A.L. Proteases as biomarkers and analytical tools in Fockens/ Krishnadat 2008 1 and 3 inflammatory diseases of the gastro-intestinal tract associated cancers Luijtgaarden van de Evaluation of Dendritic cell immunotherapy in combination Krishnadat 2009 W. with Curcumin for treating esophageal cancer Pacha A.F. Evaluation of Dendritic cell immunotherapy in combination Krishnadat 2008 3 with Curcumin for treating esophageal cancer Timmer M. Evaluating molecular strategies for treatment of Barrett's Krishnadat 2011 3 esophagus Westra W.M Investigating molecular targets for treatment of Barrett’s Krishnadat 2008 2 esophagus Oncogenomics(AMC/UvA) Bate Eya-L BCL2 inhibition in Neuroblastoma Molenaar/Versteeg 2010 Commandeur, M. neuritogenesis in neuroblastoma Versteeg/Westerhou 2012 3 t
34 – PhD research program
Eleveld T Relapse neuroblastoma Molenaar/Versteeg 2012 Groningen van T. The role of Notch signalling in Neuroblastoma Versteeg 2008 2 Nowakowska N. Drugging oncogenic pathways in neuroblastoma Versteeg 2009 Santo, Evan FOX03 in neuroblastoma Versteeg 2007 1 /Westerhout Pathology (AMC/UvA) Andel van H. WNT signaling and CYLD in multiple myeloma Pals/Spaargaren 2011 3 Hoogeboom R.* Identification of antigen receptor ligands of B-cell Van Noesel/ Bende 2007 3 lymphocytic leukemia immunoglobulin-homology groups Keimpema van M. The role of the forkhead transcription factor FOXP1 in B-cell Spaargaren/Pals 2008 3 non-Hodgkin lymphoma Mackovicová K. Targeting of Activation-induced Cytidine Deaminase (AID) Van Noesel / 2010 1 dependent DNA Double-stranded Breaks and Long-range Guikema DNA interactions Matlung S.E. BASIS genetische analyse van mammacarcinomen; (Breast Van de Vijver 2011 2 Cancer Somatic Genetics Study) Ren, Z Heparan sulfate proteoglycans and WNT-signaling in Spaargaren/Pals 2013 2 multiple myeloma Rooij de M. The role of cell adhesion in B-cell malignancies Spaargaren/Pals 2009 1 Savci C.D Identification and validation of predictive markers for drug Van de Vijver 2009 4 response in metastatic breast cancer. Slot L. Chronic antigenic stimulation and development of low- Van Noesel / Bende 2010 3 grade B cell non-Hodgkin (NHL) lymphomas
Theme 2: Experimental Clinical Research
Name Title of Project Supervisor Fund Molecular Pathology (NKI) Beelen K. Clinical and molecula evaluation of anti-estrogen resistance Linn 2009 4 in breast cancer Broek, van den S. Genetic determinants of survival and second breast cancer Schmidt 2009 3 development in premenopausal breast cancer patients Bronsveld H. CARING Schmidt 2012 2 Cornelissen, L. Identification of Genes contributing to breast cancer Jonkers 2012 2 development in GEMMSs Dackus G. Applied breast cancer diagnostics T3-502 Linn 2012 3 Droog M. Molecular mechanism of endocrine resistance Zwart 2011 1 Elshof, L. Finding the balance between overdiagnosis an Wesseling 2012 3 dundertreatment: risk of ipsilateral and contralateral invasive breast cancer and breast cancer death after primary ductal carcinoma in situ Flach K. A genomics-based tool to predict tamoxifen response Zwart 2012 4 Frederix F.* Cost effectiveness of breast cancer therapies Schellens 2009 4 Geel van, R. Clinical Pharmacology of out-coude drufs Schellens 2011 4 Hasselt van C.# Population PK-PD-modelling in oncology Schellens 2009 4 Jacobs B. Development and clinical testing of novel formulations for Schellens 2011 1
PhD research program - 35
oral fluoropyrimides Jaspers J.* The role of tumor-initiating cells in cancer metastasis and Jonkers / Rottenberg 2008 2 drug resistance Jong, de M. Prediction of local control after radiotherapy in head and Begg 2007 3 neck cancer Kas S. Identification of genes nvolved in breast cancer Jonkers 2011 2 development and therapy resistance Klarenbeek, S. PI3K signaling in mouse models of invasive lobular breast Jonkers 2008 1 cancer Koornstra R.# Predicting hormonal treatment sensitivity in breast cancer Linn 2007 4 Leijen S.* Development of contribution therapy with anti cancer drugs Schellens 2008 4 Meulendijks D. Phase Iand II studies in oncology with focus on gastro- Schellens/Cats 2011 4 intestinal malignancies Milojkovic B. Clinical Pharmacology of anti-cancer drugs Schellens 2011 4 Noll, van der N. Clinical Pharmacology of novel tyrosine kinase inhibition Schellens 2010 4 Parsi, P.# Cancer risk and insulin analogues (CARING) Schmidt 2012 4 Salomon I. Microban Linn 2005 2 Schouten P. Prediction of chemotherapy response based on genomic Linn 2010 2 aberrations Severson, T. Molecular characterization of ER positive, triple negative Linn 2012 2 and BRCA1 mutated breast cancer Sobral Leite, M. Breast Cancer, Biomarkers and Therapeutic Response Schmidt 2013 4 Stelloo, S. Integrative androgen receptor genomics as read out for Zwart 2013 4 recurrence risk & ttreatment restistance of prostate cancer Stuurman R.* Orale pharmacology van taxanen Schellens 2009 4 Verhagen C.# Fanconi anemia pathway defects in HNSCC Begg 2008 1 Vollebergh M. Predicting therapy responses in breast and lung cancer Linn 2007 3 Medical Oncology (NKI) Alphen van M. Virtual Surgery in Oral Cancer Van der Heijden 2012 1 Boshuizen R. Selectikine/EMD malegrant pleural effusion Van der Heuvel 2009 4 Djajadiningrat R. Penile squamous carcinoma Horenblas 2011 1 Dohmen A. Short term cultures of NSCLC and HNSCC for manipulating De Zuur 2011 4 and predicting treatment responses Foppen, M. Clinical aspects of immunotherapy and targeted therapy of Haanen 2013 1 advanced melanoma Gooijer de, M. Improved treatment of intracranial tumors - focus on the Van Tellingen 2013 blood-brain barrier Kist J. Towards personalised treatment based on evaluation of ET Vogel 2011 3 in recurrent differentiated Hyroid cancer Kuijpers A. Pathway activation in colorectal carcinoma and colorectal Verwaal 2012 1 metastasis Mertens L. Bladder Cancer Horenblas 2011 1 Meulenaar, J.* Drug formulation and clinical testing of anticancer drugs Schellens/Beijnen 2008 4 Mirck B. Surgery for metastatic colorectal cancer Verwaal 2011 4 Moes J.* Oral Taxanes: pharmaceutical and clinical development Schellens/Beijnen 2007 2 group pilot programme transletinal onderzoek
36 – PhD research program
Nijenhuis C. Bioanalysis, metabolism and clinical pharmacology of Beijnen/Schellens 2012 4 anticancer drugs (vemurafenib) Pengel K. CTMM breast care Gilhuijs 2009 4 Rigter, L. Colorectal neoplasia in high risk populations Van Leerdam 2013 1 Samuels, S. Safety ethicary and immunogenicity of HPV16E1 caccination Kenter 2012 1 in HPV related squamous cell cancer Schaake E. Individualised therapy in thoracic malignancies Burgers 2009 4 Stiekema J. Genetic Profiling in Oesophageal Cancer Van Sandick 2010 4 Stoker S. Nasopharyngeal carcinoom Tan 2011 3 Swellengrebel M.* Optimizing peri-operative treatment of rectal cancer Cats/Marijnen 2008 4 Uyterlinde W. Supportive care in the treatment of NSCLC v.d. Heuvel 2008 1 Weger de, V. Clinical development of anti cancer drugs through Schellens 2013 4 modulated absorption Wessels R. Optical vuvar biopsy by optical coherence tomography van Beurden 2010 1 (DCT) Wildeman M.* Early detection of primary and recurrent nasopharyngeal Tan 2008 3 carcinoma using (anti-) EBV based tumor markers and option Pharmacy and Pharmacology (NKI) Aalbersberg E. Molecular imaging of radiolabeled cisplatin Vogel 2012 1 Fan L.* The impact of ABC transporter in the Blood-Brain Barrier on Beijnen 2009 4 the brain penetration of drugs and their efficacy against in Radhakishun N. The effects and treatment of obesity in children and Van Vliet 2011 1 adolescents Psychosocial Research and Epidemiology (NKI) Boekel N. Cardiovascular morbility and mortality in breast cancer van Leeuwen 2008 3 survivors Eggermond van A. Long term risk of second hand cancer and cardiovascular Floor van Leeuwen 2009 3 disease followeing treatment of Hodgins lymphoma Eijzinga W. Identification of psychosocial problems and perceived need Bleiker 2008 3 for support in cancer genetics Feenstra H. An online testing approach to assess cognitive problems Schagen 2011 3 associated with cancer and cancer treatment Groot H. Longterm risk of cardiovascular disease + 2nd malignancies Schaapsveld 2012 3 after platinumbased CT for malignant testicular germcell canc Hummel, L. A randomized study of an internet-based cognitive Aaronson 2012 3 behavioral therapy program for sexuality and intimacy problems in women Jacobse, J. Cardiovascular morbiolity and mortality in breast cancer Van Leeuwen 2013 4 survivors;identifying high risk subgroups Kemperman M. CONNECT Cognition and the Neural Network: Effect of Van Leeuwen 2010 1 Chemotherapy Krul I. Late effects of treatment in female survivors of Hodgkin's Floor van Leeuwen 2012 3 lymphoma with an emphasis on premature menopause Kuijpers W. ACARE2 MOVE. IT supported patient empowerment Van Harten 2010 3 Menning S. Structural biochemical and functional indices of CF inducted Schagen 2010 3 cognitive deficits in concepts
PhD research program - 37
Meulepas J. Cancer risk due to radiation exposure from paediatric Hauptmann 2011 2 computed tomography Miquel Cases A. CTMM-breast Van Harten 2011 4 Nimwegen, van R. Long term cardiovascular risks after treatment for Hodgkin Van leeuwen 2010 3 Lymphoma Rayan A. Eurocan Van Harten 2011 4 Schrijver L. Gene-hormone use interactions in BRCA 1/2 mutation Rookus 2010 4 carriers: modification of breast and ovarian cancer risk within CIMBA Spaan M. OMEGA, long term risk of cancer after ovarian stimulation Van Leeuwen 2010 3 for in-vitro fertilization Verloop J.* Long-term effects f exposure to DES in utero on the risk of Van Leeuwen 2001 3 hormone-related cancers Waart van H. Effectivities of physical exercise Aaronson 2009 3 Wevers M. Behavioral and psychosocial effects of rapid genetic Aaronson 2008 4 counseling and testing in newly diagnosed breast cancer patients Wind, A. Benchmarking of Compreshensive Cancer Care Van Harten 2013 2 Radiotherapy (NKI) Boer, de J. image guided corretion strategies to optimize RT precision Sonke 2006 3 Bohoslavsky R.# Probabilistic based treatment planning with biological van Herk 2008 3 objectives for high dose high-presision RT of prostate cancer Bosma, S. Radiosensitivity and local recurrence in breast cancer Elkhuizen 2013 3 Chen W. Neoadjuvant drug treatment for breast cancer-response Sonke 2009 4 prediction and response monitoring: breast care Dees-Ribbers H. High precesion image guided RT for bladder cancer Van Herk 2008 3 Diessen van, J. PET and Radiotherapy for lungcancer Sonke/Belderbos 2013 1 Haan de R. Radiotherapy and PARPI ui NSCLC/MNSCC/LABC-clinical Verheij/Schellens 2011 4 studies Hamming-Vrieze O. Dose redistribution in the presence of anatonmical changes Rasch 2011 1 in head and neck cancer Heukelom J. ARTFORCE-Adaptive and Innovative Radiation Treatment Verheij 2012 2 For Improving Kranen, van S. High precision radiotherapy in the presence of anatonical Van Herk 2005 3 deformations Kruis M. Motion compensation in YD PET Boellaard 2009 4 Leij van der F. Image guided pre operative accelerated partial breast Elkhuizen 2010 3 radiaton efining radiotherapy sensitivity Mencarelli A. High precission RT in presence of anatomic changes Sonke 2008 1 Peulen H. Optimization of sterotactic image guided RT for lung cancer Sonke 2011 3 through detailed toxizing assessment Pirpinia, K. Optimized targeting for surgery and RT of breast cancer Sonke 2013 3 with a DCIS component-regsitration Reijden, van der A. Respiratory correlated imaging for positioning and Sonke 2013 4 monitoring in lung cancer radiation therapy Stankovic, U. Improving Cone Beam CT Image quality Sonke 2012 4 Szeto, Y. Probabilistic planning protonen Van Herk 2012 4
38 – PhD research program
Trip A. Adjuvant treatment maagcarcinoom i.h.h. critics Verheij 2011 1 Uilkema, B. Response monitoring & ART bij oesopharynxcarcinoom Sonke 2013 4 Voncken, F. Response monitoring & ART bij oesopharynxcarcinoom Verheij 2013 4 Zhang H. IGRT-Breast care package Sonke 2009 1 Gastroenterology (VUmc) Pas van der M. To study possibilities of fluorescence as tool to optimise Meijerink 2007 2 staging and preoperative localisation of colon carcinoma Water van de J.M.W. Predicting T-cell lymphoma development in refractory Cillessen 2007 1 coeliac disease patients by profiling of apoptosis pathways Hematology (VUmc) Alhan C. Role of flow cytometry in the diagnosis and prognostication v.d. Loosdrecht 2008 4 of myelodysplastic syndromes van Alphen C. Phosphoproteomics for personalized treatment of acute Ossenkoppele, 2012 3 myeloid Janssen leukemia with kinase inhibitors Ancker, van den W.* Optimizing strategies in dendritic cell vaccination in myeloid v.d. Loosdrecht / 2006 1 leukaemia Ossenkoppele Issa D.E. Treatment and survival of indolent and aggressive NHL Huijgens 2009 4 patients; population based studies in the Netherlands Jauw, YJ Immuno PET to personalize therapy in malignant lymphoma Zweegman / van 2013 3 Dongen / Zijlstra Niewerth D. Application of bortezomib in pediatric acute lymphoblastic Kaspers 2009 3 leukemia Terwijn M.* Detection of residual leukemic stem cells during minimal Schuurhuis / 2006 3 residual disease in AML Ossenkoppele Verhagen H. The identification of biomarkers/drugtargets specific for Smit 2011 3 leukemic stem cells of Acute Myeloid Leukemia Wondergem M.J. Can transformation of indolent lymphoma be detected at an Huijgens / Hoekstra 2006 1 early stage by PET scanning? Zeijlemaker W. The role of minimal residual disease, and leukemic stem Ossenkoppele 2011 3 cells herein, in clinical decision making Medical Oncology (VUmc) Avan A. Genetic and molecular mechanisms underlying Pancreatic Peters / Giovannetti 2011 3 Ductal Adenocarcinoma aggressive behaviour and chemoresistance Azijli K. TNF ligands in cancer: TRIAL for cancer therapy Peters 2008 3 Chondronasiou, D VHH based therapies for cancer de Gruijl / Verheul 2013 3 Giovannetti E. Correlation of cytidine deaminase and DNA repair genes Peters 2007 4 polymorphisms with response and survival in advanced NSCLC patients Gootjes, E. Novel diagnostic and treatment strategies in metastatic Verheul 2013 4 colorectal cancer Gotink K.J. Sensitivity and resistance of tumor cells to the Verheul 2008 3 antiangiogenic tyrosine kinase inhibitor sunitinib Huijts L. Phase I-II study of everolimus and low-dose oral Verheul 2011 3 cyclophosphamide in patients with metastatic RCC Koster B.D. Immunomodulation of the sentinel lymph node de Gruijl 2012 3
PhD research program - 39
Kuipers L. Cancer therapy with the proteasome inhibitor Bortezomib Peters 2008 3 and the death ligand TRAIL for non-small cell lung cancer Lam S.W. A multicenter, randomized phase II trial of paclitaxel plus Boven 2010 4 bevacizumab versus paclitaxel, bevacizumab plus capecitabine Neefjes E.C.W. Early recognition and optimal treatment of delirium in Verheul 2011 3 patients with advanced cancer Neerincx M. Individualized treatment of patients with advanced Verheul 2011 3 colorectal cancer based on miRNA expression profiling Offringa T. Chemotherapy and maximal tumor debulking of multi-organ Verheul / Buffart 2012 5 coloractal cancer metastases Poel D A randomized multicenter clinical trial for patients with Verheul / Buffart 2013 3 multi-organ, colorectal cancer metastases Schulkens I. Exploring the role of endothelial galectins in tumor Griffioen 2009 3 angiogenesis Schuurhuizen C. Screening and treatment of psychological distress in Verheul / Dekker 2013 3 colorectal cancer with metastasized disease (TES) Sol N. Monitoring of response to EGFRvIII-targeted treatment in Verheul / Reijneveld 2013 3 patients with glioblastoma through blood profiling Veluchamy J NK cell-based therap for EGFR+ tumors de Gruijl / Verheul 2013 3 Versteeg K.S. Optimalization of systemic treatment strategies in elderly Verheul 2012 3 patients with advanced solid malignancies Walraven M. Platelet proteomics for cancer biomarker discovery Verheul/Jimenez 2008 3 Wentink M. Development of a therapeutic vaccine approach to anti- Verheul 2012 4 angiogenesis in oncology Westgeest H. Pharmacoeconomical evaluations in castration-resistant Verheul / Uyl-de 2013 3 prostate cancer Groot Zweeden A. van New therapies for disseminated gastro intestinal cancer Verheul 2013 4 Neurology (VUmc) Froklage F. Assessment of blood-brain barrier function in Reijneveld 2008 2 pharmacoresistant patients with tumor-related epilepsy Koekkoek, JAF Epilepsy in glioma patients during the course of disease and Taphoorn / Heimans, 2013 4 in the end of life / Reijneveld / Dirven Sizoo E. Health-related quality of life in high-grade glioma patients Taphoorn 2008 3 and their partners in the end-of-life phase Nieuwenhuizen van Quality of life and neurocognitive functioning in Reijneveld 2008 1 D. meningioma patients Neurosurgery (VUmc) Best, M Minimally invasive diagnostics of CNS tumors Wesseling / 2013 Wurdinger Hiddingh L. Development of preclinical pediatric brain tumor imaging Würdinger 2010 3 models Nutricion and dietics (VUmc) Buskermolen S. Prevalence and biomarkers of pre-cachexia and cachexia in Verheul 2011 3 advanced cancer patients scheduled for chemotherapy treatment van der Werf A The effect of individualized NUTritional counselling on Verheul 2013 3 muscle mass and treatment outcome Obstretics and Gynaecology (VUmc)
40 – PhD research program
Hooi, D HPV screening at Curacao Meijer / Kenter 2013 Oral and Maxillofacial Surgery and Pathology (VUmc) Dekker H. Peri-implantitis, implan loss and radio-osteomyelitis in head Bloemena 2010 3 and necktumor patients Orthopaedics (VUmc) Posthuma de Boer J. Treatment of osteosarcoma lung metastasis through Kaspers / van 2008 4 targeted therapy Beusechem Otolaryngology / Head and Neck Surgery (VUmc) de Boer D.V. Targeted therapy of precancerous fields in head and neck Brakenhoff RH, 2012 3 mucosa Leemans CR Bruijn M. de* Objective speech assessment in head and neck cancer: Verdonck-de Leeuw 2008 3 acoustic-phonetic and feature analyses by a neural network Cnossen I.C. Prevention of speech, swallowing, and shoulder impairment Verdonck-de Leeuw 2009 4 after treatment for head and neck cancer Cohen R. The selective targeting of angiogenesis and of tumour Van Dongen / de 2008 2 stroma Bree / Leemans Flach G.B. The sentinel node procedure in head and neck cancer: De Bree / Van 2007 3 clinical value and potential technical improvements Dongen Gogh van C.D.L. Voice therapy for patients with voice problems after Mahieu 2002 2 treatment for early glottic cancer Jansen, F Need, use, and costs of supportive care in head and neck Verdonck-de Leeuw/ 2013 2 cancer patients Leemans Lo Galbo A.M. Hypothyroidism after treatment for laryngeal cancer Leemans 2005 1 Heuveling D.H. Improvement of the sentinel node procedure in head and De Bree / Van 2008 4 neck Dongen cancer by PET-CT lymfoscintigraphy Oskam I.M. Health related quality of life in head and neck cancer Leemans 2004 1 patients Putten van der L. FDG-PET for avoidance of futile direct laryngoscopies under Leemans 2005 3 general anasthesia with taking of biopsies in patients Rietbergen M. Clinical significance of human papillomavirus infection in Brakenhoff 2009 3 oropharyngeal squamous cell carcinoma Schouten C.S. Response evaluation after chemoradiation for advanced de Bree R 2012 2 oropharyngeal cancer using PET-CT and MRI Senft A. Screening for distant metastases and second primary Leemans 2002 2 tumors with FDG-PET (the school study) Slobbe P. The development of radiolabeled tyrosine kinase inhibitors Van Dongen 2011 3 for PET imaging Pathology (VUmc) Cordes M. Molecular biomarkers for the stratification of metastatic Meijer, Ylstra 2012 3 colorectal cancer patients Goos J.A.C.M. Personalized therapy in recurrent colorectal cancer Hoekstra / Meijer 2009 3 Haan J.C. Prediction of response to drug therapy in advanced Meijer / Ylstra 2007 3 colorectal cancer based on DNA copy number profiles of primary tumors Krijgsman O. Clinical and biological relevance of focal aberrations in Meijer 2008 3 colorectal cancer Lubbers J. Genomic biomarkers to predict development of RA (VERA, Verweij 2011 3 ERA)
PhD research program - 41
and therapy responsiveness (ESRA) Mollers M. HPV infections and immune status in a cohort of girls who Meijer 2009 3 are eligible for the national HPV immunisation Polman, N Comparison of the clinical performance of HPV screening via Meijer / Snijders / 2013 2 self-sampling with clinician-based sampling in a population- Berkhof based screening setting Ramayanti O. Epstein barr virus activation and cytolytic antivirual therapy Middeldorp 2011 3 in nasopharyngeal patients Schütze D.M. Comprehensive analysis of the long-term oncogenic Snijders 2009 3 capacity and in vitro transforming property of the 15 high- risk human papillomavirus types (hrHPVs) Snellenberg S. Development and clinical validation of a methylation marker Snijders 2009 3 set for the triage of hrHPV positive women Snoek, B Molecular Self Screening for Cervical Cancer Prevention Snijders / Meijer / 2013 2 Steenbergen / Heideman Strooper L. de Stratifying high-risk HPV positive women for risk of CIN 3 Heideman 2010 3 and cervical carcinoma by methylation analysis Uijterwaal M. Simplified monitoring post-treatment CIN 2/3 women by Meijer 2010 3 molecular testing for hrHPV and methylationmarkers (SiMoNaTh) Verhoef V. HPV self-sampling offered to screening non-attendees Meijer 2010 3 Verlaat, W Molecular Self Screening for Cervical Cancer Prevention Snijders / Meijer / 2013 3 Steenbergen / Heideman Verweij F.J. Involvement of EBV gene products in exosome-mediated Middeldorp 2009 3 tumor immune escape Voorham Q.J.M.* Increasing sensitivity for detection of high risk flat Meijer 2006 3 adenomas in population screening for colorectal cancer van Zummeren, M Mass-care Meijer, C/ Snijders, P 2013 3 Paedriatic Oncology (VUmc) Bachas C. Characterization of relapsed acute myeloid leukaemia Cloos/ Schuurhuis 2007 1 Blufpand H.N. Carboplatin study: assessment and optimization of Bökenkamp 2010 4 carboplatin exposure in pediatric oncology using different markers Braam K.I. Silicone gel sheet to improve cosmetic outcome of scar after Van Dulmen-den 2007 4 removal of implantable central venous access device Broeder/Kaspers Franke N. Drug resistance in childhood leukemia Cloos / Kaspers 2006 4 Gordijn M.S.* Dexamethasone and function of the HPA axis in children Kaspers 2011 3 after treatment for Acute Lymphoblastic Leukemia Gunawan, S Clinical challenges of pediatric oncology in Manado, Kaspers, GJL 2013 Indonesia Jansen M.H.A. Towards comprehensive therapy for diffuse intrinsic Kaspers 2009 4 pontine gliomas in children Janzen J Growthfactors for treatment for of diffuse intrinsinc Kaspers, GJL/ 2013 4 ponsglioma Vandertop, WP/ Hulleman, E Kors W.A. Retinoblastoma Cloos 2005 1 Krebber A.M.H. A stepped care programme in patients with high distress Verdonck-de Leeuw 2008 3 after treatment for head and neck cancer
42 – PhD research program
Mir S.E. Therapeutic potential of histone deacetuylase inhibitors in Kaspers / Cloos 2007 2 the treatment of Medulloblastoma Njuguna F Compliance with childhood cancer treatment in Kenya Kaspers / Mostert 2013 Olbara, G A medication diary-book for childhood cancer patients in Kaspers/ Mostert 2013 Kenya Overbeek A. Reproductive function, ovarian reserve, and risk of Voskuijl 2008 3 premature menopause in female childhood cancer survivor Susilawati D Compliance with childhood cancer treatment in Yogyakarta, Kaspers / Mostert 2013 Indonesia Veldhuijzen van Drug distribution and local drug delivery in diffuse intrinsic Kaspers / Vandertop 2012 3 Zanten S.E.M. pontine glioma Veringa, SJE In vitro drug response and efflux transporters associated Kaspers / Hulleman / 2013 3 with drug resistance van Vuurden Vuurden van D.G. Targeted therapy in pediatric brain tumors Kaspers 2005 1 Pulmonology (VUmc) Mellema W.W. New treatmentmodalities for lung cancer patients with a K- Smit 2011 3 RAS mutation Phernambucq E.* Multimodality treatment in NSCLC Smit 2008 3 Radiation oncology (VUmc) Narayan R.S. Targeting resistance to radio-chemotherapy by inhibition of Slotman 2011 3 the PI3Kinase-Akt signaling pathway Tol J. Optimization and automation of radiotherapy treatment Verbakel 2009 2 planning Radiology & Nuclear Medicine (VUmc) Hoyng L.L. Quantitative imaging in cancer: connecting cellular Boellaard 2011 3 processes with therapy: Data and Image Analysis (WP4) de Jong, A Beating malignant lymphoma with an imaging-biomarkers Nievelstein, RAJ/ 2013 3 based personalized treatment strategy Hoekstra, OS de Jong M.C. Multicenter implementation of MR imaging studies in Castelijns 2012 3 children with retinoblastoma Makris N. PET methodology: quantification of long-lived PET tracers in Boellaard 2010 4 oncology and immunology Rizvi S.N. Qualifying imaging biomarkers for response evaluation in Hoekstra 2010 4 cancer Rodjan F. Optimization of MR imaging studies in retinoblastoma Castelijns 2010 3 patients Scheffer H.J. Evidence based interventional oncology: from last resort to van Kuijk/ Meijerink 2012 1 potent alternative or additional treatment? Reumatology (VUmc) Verbrugge C.S.E Proteasome inhibitor targeting of the Dijkmans / Jansen 2008 1 (immuno)proteasome: effects on immune effector cells Surgery (VUmc) Ankersmit M. Photoimmunodetection of colorectal cancer Meijerink 2011 3 De Cuba E. Peritoneal metastases from colorectal carcinoma; Bonjer 2010 1 Diagnostic markers to identify patients thatbenefit from radical surgical resection
PhD research program - 43
Nielsen K. Imaging and local treatment of colorectal liver metastasis Meijer, Comans 2011 3 Straatman C The STOMACH trial: Surgical Technique Cuesta MA 2013 4 Urology (VUmc) Al-Itejawi H De patient centraal bij de behandelkeuze voor van Moorselaar RJA 2013 3 prostaatkanker Surgery (VUmc/AMC) Sier M.F. Stoma-related research in colorectal cancer patients Ubbink, Bemelman 2009 1 and 2 Hematology (AMC/UvA) Munneke J.M. T cell kinetics during immune reconstition after Van Oers/Hazenberg 2011 1 hematopoietic stem vcell transplantation Gastro-enterology & Hepatology (AMC/UvA) Alvarez-Herrero, L Advances in imaging and therapy in Barrett's esophagus Weusten/Bergman 2011 4 Barendse R.* Treatment of large rectal adenomas Fockens/ Dekker 2009 2 Berg M.van den New endoscopic developments in GI oncology Fockens/van Hooft 2011 Boerwinkel, D Imaging of early barrett's neoplasia Bergman 2011 4 Bureo Gonzalez A. Epidemiology of Barrett's surveillance Bergman 2013 4 Denters M.* Screening for CRC with repeated FOBT in the Netherlands Fockens / Dekker 2008 2 Duits L.C. Risk stratification for Barrett's esophagus Bergman 2012 4 Hazewinkel Y. Serrated polyposis syndrome: endoscopic treatment and Dekker 2010 3 surveillance of patients and screening of first-degree relatives Holz J.A. Light-tissue interactions in esophageal neoplasia v. Leeuwen/Bergman 2011 3 Kuiper T.* Advanced colonoscopic imaging Fockens/ Dekker 2009 4 Künzli H.T. New treatment options for esophageal neoplasia Weusten/Bergman 2012 4 Phoa N Endoscopic treatment of early esophageal neoplasia Bergman/Tijssen 2011 4 Rosmolen W.D. Quality of life of patients with Barrett's neoplasia Sprangers/Bergman 2010 4 Schölvinck D.W. New endoscopic therapies for early esophageal neoplasia Weusten/Bergman 2012 4 Stegeman I.* Risk-profiling in CRC-screening Dekker 2009 2 Swager A.F. Volumetric laser endomicroscopy in esophageal imaging Bergman 2012 4 van der Vlugt, M Fourth round op FIT-screening for CRC Dekker/Bossuyt 2013 2 van der Wel M. Optimizing histological diagnosis making in Barrett's Bergman/vd. Vijver 2013 4 neoplasia Van Doorn S. Diverse aspects of colorectal cancer screening Dekker 2011 2 and 4 Verlaan T. Transmural endoscopy Fockens/Bemelman 2010 Wanders L. Advanced colonoscopic imaging Dekker 2011 2 and 4 Wijkerslooth T. de* Population screening for colorectal cancer by colonoscopy Fockens / 2008 2 or CT-colonography in the Netherlands Bossuyt/Dekker IJspeert, J Serrated polyposis Dekker 2013 2 and 4 Gynaecology (CGOA) Biewenga P. Prognostic models in carcinoma of the cervix Buist/Stalpers/Kenter 2007 3 Derks M. Morbidity and QOL after treatment for cervical cancer v.Lonkhuizen/kenter 2010 2 Meurs H.v. Improving treatment strategies in ovarian cancer Buist/Kenter/Mol 2010 3 Rutten M. Prognostic models in ovarian cancer Buist/Kenter/v.d.Vijv 2010 1 er
44 – PhD research program
Stiekema A. Biomarkers in ovarian cancer Lok/Kenter 2011 Wegdam W. Role of proteomics in ovarian carcinoma Buist/Aerts/kenter 2007 1 Medical Oncology (AMC/UvA) Anderegg M.C.J. New treatment strategies of oesophageal cancer Busch/Van Berge 2012 1 Henegouwen/Van Laarhoven Bulten B. Early detection of cardiac malfunction in breast cancer De Geus-Oei/van 2011 patients Laarhoven/Oijen Ebbing E.A. Receptor signalling in oesophageal cancer van Laarhoven / 2012 Medema / Bijlsma / Punt Haj Mohammad N. Treatment of upper gastrointestinal cancer in daily practice: van Laarhoven/tbd 2013 1 toxicity, quality of life and survival Hidding J. Lymphedema in breast cancer Nijhuis/vanLaarhove 2011 n/Beurskens/van der Wees Klaassen R. Functional imaging of pancreatic cancer van 2013 3 Laarhoven/Punt/Ned erveen Kleinjan A. Cancer and (anti)coagulation Buller / Kamphuisen 2010 1 / Richel Kruizinga R. Experiences of contingency in advanced cancer patients van 2012 3 Laarhoven/Schilderm an/Scherer-Rath Linnekamp J.F. Methylation in colon cancer Medema / van 2013 3 Laarhoven / Vermeulen / Dekker Visser A. Group medical consultations in breast cancer care Prins / van Laarhoven 2011 3 / Hoogerbrugge Voert E. ter Functional imaging of colorectal cancer Heerschap/van 2009 3 Laarhoven/De Geus- Oei Vries Y. de Sensory changes after cytotoxic treatment Kampman/tbd/van 2012 3 Laarhoven/Winkels Pediatric Oncology (AMC/UvA) Dijk van I.W.E.M. Late effects of radiotherapy in childhood cancer survivors Caron / Koning / 2010 3 Kremer Eijkelenburg van N. Ealry phase medication studies for childhood cancer Caron / Verschuur 2007 3 Knijnenburg S.* Website aimed at childhood cancer survivors Jaspers / Kremer 2007 3 Knops R.R.G. Quality care in paediatric oncology Hulscher/Kremer 2009 3 Mulder R.* Late effects of childhood cancer survivors Caron / Kremer 2008 3 Sieswerda E.* new drug development, clinical trials and late effects Caron/ Kremer 2007 3 Psychosocial department (UvA/AMC) Aukema E.J.* Late consequences and needs of young survivors of a brain Grootenhuis 2006 1 tumor and their parents Last/Schouten/ Ruiter de M. Pediatric research on improving speed, memory and Grootenhuis / Caron 2008 3 attention / Oosterlaan/ Schouten Schepers S.A. Living with chldhood cancer Grootenhuis/Verhaak 2011 3
PhD research program - 45
Sint Nicolaas S. Living with chldhood cancer Grootenhuis/Prins/ 2011 3 Verhaak Radiotherapy (UvA/AMC) Balidemaj E. Improved regional hyperthermia delivery using Rasch / Crezee / van 2010 3 hyperthermia treatment planning based on MRI data den Berg(UMCU) / Stalpers Boer, P. de Adaptive radiotherapy for cervical cancer Stalpers/Rasch 2011 1 Dinkla A. Brachytherapy treatment planning: optimisation and Rasch / Bel 2010 1 and 4 evaluation Gurney-Champion, MRI for pancreas Bel/Nederveen/ 2012 3 O. Rasch/Stoker Heerden, L. van Multimodality dose summation brachy/EB Bel/Pieters/Rasch 2013 3 Jelvehgaran, P. Oes OCT Alderliesten/ De 2013 3 Bruin/ Et al. Jin, P. Margin reduction Oes.irradiation Alderliesten/Hulshof/ 2013 3 Rasch Leeuwen C. van Towards biological treatment planning in radiotherapy Kok/Crezee/Stalpers/ 2012 3 combined with hyperthermia to improve clinical outcome Rasch Lens, E. IGRT for pancreas Bel/vTienhoven/ 2012 3 Rasch Lutkenhaus, L. Advanced ART techniques Bel/Hulshof/Rasch 2012 3 Machiels, M. Target definition in radiation for Oes cancer Hulshof/Alderliesten/ 2013 1 Rasch Oorschot B. van Investigation of a gene set classifier for late radiation Medema / Franken 2010 3 toxicity in prostate cancer patients Oei, A Towards biological treatment planning in radiotherapy Franken / Kok / 2012 3 combined Stalpers / Medema with hyperthermia to improve clinical outcome Pirpinia, K. Deformable image registration Aldrliesten/Bosman/ 2013 3 vHerk Schooneveldt G. Optimization of bladder hyperthermia treatment for NMIBC Crezee / Hulshof / 2012 3 by using loco-regional heating, improved 3-D thermometry Rasch Schoot, S. van der ART for cervical cancer Bel/Stalpers/Rasch 2012 3 Versteijne, E. pancreas Tienhoven/Bel/Rasch 2013 1 Tytgat Institute (AMC) Büller, N The role of Hedgehog signaling in intestinal homeostasis Van den Brink 2010 3 and carcinogenesis Heijmans J.* Female hormones and colon cancer development Van den Brink 2008 3 Lidth de Jeude J. The role of Hedgehog signaling in intestinal homeostasis Van den Brink 2011 2 and carcinogenesis Rosekrans S. The role of Hedgehog signaling in esophageal homeostasis Van den Brink 2010 2 and carcinogenesis Wielenga T. The unfolded protein response in colorectal cancer Van den Brink 2011 3 development and sensitivity to chemotherapy Westendorp F. Intestinal mesenchymal cell function in homeostasis and Van den Brink 2013 2 disease Urology (AMC/UvA) Beemster P. Cryosurgery of small renal tumors De la Rosette/ 2005 1
46 – PhD research program
Laguna/ Wijkstra Smeenge M. Imaging in Urology De la Rosette/ 2009 Laguna
PhD research program - 47
48 – PhD research program Oncology Graduate School Amsterdam OOA
awards 5
the Lifetime Honorary Membership Award of the The British Society for Dermatopathology 5. Awards A Gravity subsidy was awarded to a consortium that was lead by Jacques Neefjes
Karin Nielsen received the ´kanker in beeld´award This chapter lists awards and honors won by staff and students involved in OOA throughout 2013. The Fred van Leeuwen received a Vici grant lists are in alphabetical order of the recipients’ last name. Gert Ossenkoppele was awarded with the Prof Neuwirth Award Faculty and staff members of the OOA fulfilled numerous functions in national and international Inge Verbrugge received a Bas Mulder award organizations, on scientific boards of scientific journals, as members of study sections, and as Karin de Visser received a consolidator ERC grant organizers or co-organizers of scientific meetings, workshops and congresses. Isaac van der Waal was nominated with Honorary membership at the Spanish Association of Oral Reuven Agami received an advanced ERC grant Medicine
Amir Avan was awarded with the Chris Meijer prijs
Susanne Blauwhof-Buskermolen received the NVO Travelgrant
Thijn Brummelkamp (an OOA alumnus) was the first Dutch scientist to receive the highly prestigious EMBO gold medal
Rene Bernards received the KNAW Academy Professorship, a lifetime achievement award
Adrian Begg received a lifetime achievement award from ESTRO.
Harry Bartelink received the European Breast Cancer Science Award.
Janny Borst was elected as member of EMBO
Joost Dekker was awarded with the Distinguished International Affiliate of the American Psychological Association
Linda Douw received a NWO Veni grant
Elisa Giovanetti was awarded with the Berlucchi Award for Young Italian Researchers
Tanja de Gruijl and Sue Gibbs were awarded with the Fenna Diemer Lindeboom Chair
Daniëlle Heideman was nominated ‘Klinisch moleculair bioloog in de pathologie’ (KMBP)
Rene Medema was elected as member of the KNAW
Chris Meijer received a FP7 grant
Gerrit Meijer became Eatris national co-director
Wolter Mooi received the Dr Neil Smith Medal for outstanding contributions to dermatopathology and
Awards - 51
52 - Awards
Oncology Graduate School Amsterdam OOA
faculty and staff
annex 1
Annex 1. Faculty and staff of OOA
FACULTY
Prof. dr. N.K. Aaronson, Department of Prof. dr. P. Borst, Department of Molecular Psychosocial Research and Epidemiology, NKI Oncology, NKI (Theme 1). (Theme 2). Drug transporters Health-related quality of life assessment and behavioural interventions in clinical oncology Prof. dr. E. Boven, Department of Medical Oncology, VUmc (Theme 2). Dr. R. Agami, Department of Gene Regulation, NKI Kinase inhibitors in renal cancer (Theme 1). Identifying and characterizing novel cancerous Prof. dr. R.H. Brakenhoff, Department of processes. Otolaryngology-Head & Neck Surgery, VUmc (Theme 1 and 2). Dr. J.A. Aten, Department of Cell Biology and Molecular mechanisms in precursor lesions and Histology, AMC (Theme 1). early stages of head & neck cancer for early Interactions of DNA double strand breaks and detection repair proteins in the formation of chromosome translocations and cell killing by ionizing radiation Prof. dr. R. de Bree, Department of Otolaryngology-Head & Neck Surgery, VUmc and other therapeutic agents. (Theme 1 and 2). Dr. R. Beijersbergen, Department of Molecular Molecular mechanisms in precursor lesions and Carcinogenesis, NKI (Theme 1). early stages of head & neck cancer for early Unraveling signalling networks in cancer detection
Dr. A. Bergman, Department of Molecular Genetics Dr. T. Brummelkamp, Department of NKI (Theme 1) Biochemistry, NKI (Theme 1) Investigating the role of microenvironment in Experimental Biomedical Genetics prostate cancer development Prof. dr. H. N. Caron, Paediatric Oncology, AMC Prof. dr. R. Bernards, Department of Molecular (Theme 1 and 2). Carcinogenesis, NKI (Theme 1). Functional Paediatric Oncology: new drug development, genomics clinical trials and late effects
Prof. dr. A.J.M. Berns, Department of Molecular Genetics, NKI (Theme 1). Prof. dr. J.A. Castelijns, Department of Radiology, Mouse models for cancer VUmc (Theme 2). Imaging in head and neck cancer Prof. dr. J.H. Beijnen, Division of Pharmacology, NKI (Theme 2). Dr. J. Crezee, Department of Radiation Oncology, Clinical pharmacology of anticancer drugs AMC (Theme 2). New hyperthermia techniques and development Dr. C.U. Blank, Department of Immunology, NKI and application of hyperthermia treatment (Theme 1 and 2). planning. Combating targeted therapy and immunotherapy Dr. O. Dalesio, Department of Biometrics, NKI Dr. E. Bleiker, Department of Psychosocial (Theme 2) Research and Epidemiology, NKI (Theme 2) Psychosocial issues in cancer genetics Prof. dr. G.A.M.S. van Dongen, Department of Otolaryngology-Head & Neck Surgery, VUmc Prof. dr. E. Bloemena, Department of Pathology, (Theme 1 and 2). VUmc (Theme 1 and 2). Molecular imaging of cancer for diagnosis in Molecular profiling of head & neck tumors therapy selection with a focus on PET
Prof. dr. J.G. Borst, Department of Immunology, Dr. E.F. Eldering, Department of Experimental NKI (Theme 1). Immunology, AMC (Theme 1). Molecular mechanisms that govern the T-cell Apoptosis regulation in immuno-hematology. responses
Faculty and staff - 55 Dr. D. Geerts, Department of Human Genetics, Prof. dr. O.S. Hoekstra, Department of Nuclear AMC (Theme 1). Medicine, VUmc (Theme 2). Developmental genes in neuroblastoma Molecular imaging using PET for therapy selection pathogenesis and response monitoring
Prof. dr. D.J. Gouma, Department of Surgery, AMC Prof. dr. P.C. Huijgens, Department of (Theme 2). Haematology, VUmc (Theme 1 and 2). Targetted Development and optimalization of treatment therapies in myeloid leukemia modalities for pancreatic cancer patients Dr. T.J.M. Hulsebos, Department of Prof. dr. A.W. Griffioen, Department of Medical Neurogenetics, AMC (Theme 1). Oncology, VUmc (Theme 2). Molecular genetics of nervous system tumors and Tumor angiogenesis and drug therapy osteosarcomas
Dr. M. A. Grootenhuis, Department of Pediatrics, Dr. M. Innocenti, Department of Molecular AMC (Theme 2). Genetics, NKI (Theme 1) Psychosocial consequences of childhood cancer Cancer cell migration
Prof. dr. T.M. van Gulik, Department of Dr. H. Jacobs, department of Biological Stress Experimental Surgery, AMC (Theme 2). Response, NKI )Theme 1 Experimental surgery on colon cancer liver Programmed mutagenesis metastases
Prof. dr. A. Hagenbeek, Department of Dr. J. Jacobs, Department of Molecular Oncology, Hematology, AMC (Theme 1 and 2). NKI (Theme 1) 1. Phase I, II and III clinical trials in the non- Telomere Damage Hodgkin lymphomas (NHL) and 2.Suicide gene therapy Dr. K. Jalink, Department of Cell Biology, NKI (Theme 1). Dr. J. Haanen, Department of Immunology and Biophysics of Cell Signaling Medical Oncology NKI (Theme 1 and 2). Immunotherapy, immunomonitoring and Dr. J. Jonkers, Department of Molecular production facility Pathology, NKI (Theme 1). Mouse models of breast cancer Dr. S.M. van Ham, Department of Immunology, AMC (Theme 1 and 2). Prof. dr. G.J. Kaspers, Department of Paediatrics, Antigen presentation in leukemias. 2. Dendritic VUmc (Theme 2). cell immunotherapy in cancer. Innovative therapies in childhood myeloid leukemia Dr. M. Hauptmann, Department of Psychosocial Research and Epidemiology, NKI (Theme 1) Prof. dr. G.G. Kenter, Department of Obstetrics Biostatistics and Gynaecology, AMC/VUmc/NKI (Theme 2). Immunosurveillance and Immunotherapy in HPV Prof. Dr. W. Van Harten, Department of related tumours and late complications after Psychosocial Research and Epidemiology, NKI treatment for carcinoma of the cervix.
(Theme 2) Prof. dr. Y. van Kooyk, Department of Molecular Early stage technology assessment, operations Biology and Immunology, VUmc (Theme 1 and 2). research and cancer rehabilitation Glycosilation and tumor immunology
Dr. U. van der Heide, Department of Radiation Dr. K.K. Krishnadath, Department of Oncology, NKI (Theme 2) Gastroenterology and Hepatology, AMC (Theme 1). Quantitative imaging for radiotherapy dose Understanding the inflammation-dysplasia- painting and follow-up carcinoma sequence within the gastrointestinal tract Prof. dr. J.J. Heimans, Department of Neurology, VUmc (Theme 1). Dr. A.B.P. van Kuilenburg, Department of Clinical miRNAs regulating angiogenesis in gliomas Chemistry, AMC (Theme 1 and 2). Inborn errors of purine and pyrimidine metabolism and paediatric Dr. M. van der Heijden, Department of Molecular oncological diseases Carcinogenesis, NKI (Theme 1 and 2) Individualized therapy in bladder cancer: Prof. dr. A.A. Lammertsma, Department of molecular targets and biomarkers Nuclear Medicine, VUmc (Theme 2). Standardization and quantification of PET image analysis Prof. Dr. M. van Herk, Department of Radiation Oncology, NKI (Theme 2). Prof. dr. Ch.R. Leemans, Department of High Precision Radiotherapy Otolaryngology-Head & Neck Surgery, VUmc (Theme 2). Dr. J. Hilkens. Department of Molecular Genetics, Molecular mechanisms in precursor lesions and NKI (Theme 1) early stages of head & neck cancer for early Genes involved in breast cancer detection
56 – Faculty and Staff
Prof. dr. A.G.J.M. van Leeuwen, LaserCenter, Prof. dr. J.J.C. Neefjes, Department of Cell AMC (Theme 2). Biology, NKI (Theme 1). Biomedical photonics for functional and molecular Chemical biology of antigen presentation and imaging anticancer drugs
Prof. dr. F.E. van Leeuwen, Psychosocial Prof. dr. C.J.M. van Noesel, Department of Research and Epidemiology, NKI (Theme 2). Cancer Pathology, AMC (Theme 1). Epidemiology B cell biology and the pathogenesis of B-NHL / The serrated neoplasia pathway to colorectal cancer Dr. F. van Leeuwen, Department of Gene Regulation, NKI (Theme 1). Prof. dr. C.J.F. van Noorden, Department of Chromatin Dynamics Pathology, AMC (Theme 1). Proteases and protease inhibitors in cancer Dr. S. Linn, Department of Molecular Pathology, NKI (Theme 2). Prof. dr. M.H.J. van Oers, Department of Molecular dissection of cancer by differential drug Hematology, AMC (Theme 1 and 2). Pathogenesis sensitivity and Immunotherapy of B cell malignancies
Prof. dr. M. van Lohuizen, Department of Prof. dr. G.J. Ossenkoppele, Department of Molecular Genetics, NKI (Theme 1). Haematology, VUmc (Theme 1 and 2). Targetted Role of polycomb-group genes in transcriptional therapies in myeloid leukemia repression and stem cell fate and tumorgenesis.
Dr. R.M. Luiten, Department of Dermatology, AMC Prof. Dr. H. Ovaa, Department of Cell Biology, NKI (Theme 2). (Theme 1) Immunology of melanoma and autoimmune or Biological Chemistry inflammatory skin diseases Prof. dr. S.T. Pals, Department of Pathology, AMC Prof. dr. J.P. Medema, Laboratory of (Theme 1 and 2). Experimental Oncology and Radiobiology, AMC Molecular pathogenesis of B cell malignancies and (Theme 1). the role of heparan sulfates proteoglycans in Cell death induction and resistance in tumor cells tumorigenesis and cancer stem cells Prof. dr. D. Peeper, Department of Molecular Oncology. NKI (Theme 1). Prof. Dr. R.H. Medema, Department of Cell Dissecting cancer cell signaling networks and Biology, NKI (Theme 1) identifying therapeutic cancer targets Cell cycle checkpoints and chromosome segregation Dr. A. Perrakis, Department of Biochemistry, NKI Prof. dr. C.J.L.M. Meijer, Department of (Theme 1). Pathology, VUmc (Theme 1 and 2). Structural biology
HPV based early detection of cervical cancer Prof.dr. G.J. Peters, Department of Clinical precursors Oncology, VUmc (Theme 2). Prof. dr. G.A. Meijer, Department of Pathology, Pharmacokinetics and response prediction in VUmc (Theme 1 and 2). oncology
Molecular classification for early detection and Prof. dr. P.J. Peters, Department of Cell Biology, personalized therapy in gastrointestinal (colon, NKI (Theme 1). gastric) cancer Nanobiology
Prof. dr. H. Meijers-Heijboer, Department of Prof. dr. P. Postmus, Department of Pulmonology, Clinical Genetics, VUmc (Theme 1). VUmc (Theme 2). Genetic cancer predisposition with a focus on Targetted drug therapy in lung cancer breast cancer Prof. dr. D.J. Richel, Department of Medical Dr. J.J. Molenaar, Department of Oncogenomics, Oncology, AMC (Theme 1 and 2). AMC (Theme 1) . New chemotherapeutic avenues for neoadjuvant Targeted drug development in neuroblastoma and adjuvant treatment of cancer patients
Prof. dr. W.H. Moolenaar, Department of Cell Prof. dr. H.P.J. te Riele, Department of Biological Biology, NKI (Theme 1). Stress Response, NKI (Theme 1). Lipid growth factor signaling Genomic instability and carcinogenesis Prof. dr. J.M. Middeldorp, Department of Pathology, VUmc (Theme 1 and 2). Prof. dr. S. Rodenhuis, Department of Molecular EBV associated carcinogenesis and early detection Pathology, NKI (Theme 2). Breast cancer therapy and prediction of response Prof. dr. C.J.J Mulder, Department of Gastro- enterology and hepatology (Theme 2). Prof. dr. J.J.M.C.H. de la Rosette, Department of Celiac disease associated lymphomagenesis Urology, AMC (Theme 2). Improving diagnosis and treatment of Urological cancers
Faculty and staff - 57 Dr. S. Rottenberg, Department of Molecular Explore the molecular and functional aspects of: Oncology, NKI (Theme 1) (1) chemokine- and B cell antigen receptor- Cancer Therapy Escape signaling; (2) HGF/MET- and WNT-signaling; and (3) heparan sulfate proteoglycans (i.e., CD44v3 Prof.dr. T.Ruers, Department of Surgical and Syndecan-1) and their modifying enzymes. Oncology, NKI (Theme 2) Dr. C.A. Spek, Department of Experimental and Dr. S. Schagen, Department of Psychosocial Molecular Medicine, AMC (Theme 1 and 2). Blood Research and Epidemiology, NKI (Theme 2) coagulation in pathophysiology Cognitive function in cancer patients Prof. dr. B. van Steensel, Department of Gene Prof. dr. J.H.M. Schellens, Department of Regulation, NKI (Theme1). Molecular Pathology, NKI (Theme 2). Chromation genomics Pharmacodynamics of anticancer drugs Dr. Marcel Stokkel, Department of Diagnostic Dr. A. Schinkel, Department of Molecular Oncology, NKI (Theme 2) Oncology, NKI (Theme 1). Genes and proteins involved in anti cancer drug Prof. dr. M.J.B. Taphoorn, Department of resistance and pharmacokinetics Neurology, VUmc (Theme 2). Quality of life in neurooncology Dr. M. Schmidt, Department of Molecular Pathology, NKI (Theme 1) Prof. dr. I.M. Verdonck- de Leeuw, Department of Molecular and genetic breast cancer epidemiology Otolaryngology/Head and Neck Surgery, VUmc (Theme 2). Prof. dr. T. Schumacher, Department of Innovative care programs in oncology Immunology, NKI (Theme 1). Dissection and manipulating antigen-specific T-cell Dr. M. Verheij, Department of Radiation Oncology, immunity NKI (Theme 2). Targeted radiosensitization Dr. G.J. Schuurhuis, Department of Hematology, VUmc (Theme 2). Dr. K. de Visser, Department of Immunology, NKI Disease profiling CML and AMC (Theme 1) Impact of the inflammatory tumor Prof. dr. S. Senan, Department of Radiation microenvironment on metastatic breast cancer and Oncology, VUmc (Theme 2). therapy Technological innovations in applied radiotherapy
Prof. dr. T.K. Sixma, Department of Biochemistry, Prof.dr. H.W.M Verheul, Department of Medical NKI (Theme 1). Oncology, VUmc (Theme 1 and 2). Angiogenesis Structural biology and phosphokinase as drug targets in gastrointestinal and renal cancer Prof. dr. B.J. Slotman, Department of Radiation Oncology, VUmc (Theme 1 and 2). Technological Prof. dr. R. Versteeg, Department of Human innovations in applied radiotherapy Genetics, AMC (Theme 1 and 2). Regulatory networks in cancer Prof. dr. E.F. Smit, Department of Pulmonology, VUmc (Theme 2). Prof. dr. M. van de Vijver, AMC (Theme 2). Targetted drug therapy in lung cancer Genetic alterations and gene expression profiles of Dr. J-J. Sonke, Department of Radiation Oncology, solid tumors NKI (Theme 2) Adaptive Radiation Therapy Dr. K. de Visser, Department of Immunology, NKI Prof. dr. A. Sonnenberg, Department of Cell (Theme 1) Biology, NKI (Theme 1). Impact of the inflammatory tumor Receptors for matrix adhesion microenvironment on metastatic breast cancer and therapy Dr. M. Spaargaren, Department of Pathology, AMC (Theme 1).
Prof. Dr. J. Wesseling, Department of Molecular Pathology, NKI (Theme 1) Molecular pathology of breast cancer
Prof. Dr. L. Wessels, Department of Molecular Carcinogenesis, NKI (Theme 1) Computational cancer biology
Dr. R. Wolthuis, Department of Cell Biology, NKI (theme 1) Mechanisms of cell cycle control in cancer
58 – Faculty and Staff
Dr. H. Wijkstra, Department of Urology, AMC (Theme 2). Minimal invasive technology in diagnoses, therapy and follow-up of uro-oncology
Dr. T. Wurdinger, Department of Neurosurgery (Theme 1). miRNAs regulating angiogenesis in gliomas
Dr. C. Zuur, Department of Cell Biology, NKI (Theme 1 and 2) Altering treatment responses in Head and Neck Cancer
Dr. W. Zwart, Department of Molecular Pathology, NKI (Theme 1) Translational endocrinology and pathological genomics in breast, prostate and endometrial cancer
Faculty and staff - 59 STAFF
Netherlands Cancer Institute
Biochemistry O. Dalesio Dr. T. Brummelkamp Dr. H. Van Tinteren Dr. A. Perrakis Dr. A. Vincent Prof.dr. T.K. Sixma E. van Werkhoven Dr. V. Van der Noort Biological Stress Response T. Benraadt Prof. Dr. H. te Riele Prof. Dr. M. Verheij Dr. H. Jacobs Diagnostic Oncology Dr. O. Balague Ponz Cell Biology Dr. A. Bartels-Rutten Dr. C. Jalink P. Besnard Prof. dr. R.H.Medema Dr. E. Bleiker Prof.dr. W.H. Moolenaar Dr. M. Bol Prof.dr. J.J. Neefjes Dr H. Van Boven Prof. dr. H. Ovaa Dr. D. Van den Broek Prof. dr. A. Sonnenberg Dr. A. Broeks Dr. R. Wolthuis A. Bruining Dr. C. Zuur Dr. K. Gilhuijs E. Groen Gene Regulation D. Hahn Dr. R. Agami S.Heijmink Dr. F. van Leeuwen D.Hellingman Prof.dr. B. van Steensel B. van der Hiel Dr. C. Hoefnagel Immunology Dr. F. Hogervorst Dr. C.H. Blank Dr. J. De Jong Prof.dr. J. Borst M. Jonker Dr. J.B.A.G. Haanen P. de Koekoek-Doll Prof.dr. T.N.M. Schumacher Dr. L. van der Kolk C. Lange Molecular Carcinogenesis F. Lalezari Prof.dr. R. Bernards E. Lips Dr. R. Beijersbergen C. Loo Dr. M. van der Heijden M. Maiburg Prof.dr. L.Wessels M. Meijer Dr. S. Muller Molecular Genetics Dr. P. Nederlof Dr. A. Bergman K. van Os Prof.dr. A.J.M. Berns R. van Pel Dr. J. Hilkens P.Pevenage Dr. M.E. Innocenti W. Prevoo Prof.dr. M. van Lohuizen Dr. E. Rosenberg Dr. M. Ruijs Molecular Oncology J. Sanders Prof, dr. P.Borst (honorary staff member) I.van ’t Sant-Jansen Dr. J.J.L. Jacobs Dr. M. Sinaasappel Dr. H. van Luenen F. Sivro-Prndeij Prof. dr. D.S. Peeper P. Snaebjornsson Dr. A. Schinkel Dr. M. Stokkel Dr. S. Rottenberg J. Teertstra Dr. O. Van Tellingen Molecular Pathology Dr. R. Valdes Olmes Prof. Dr. J. Jonkers Dr. E. Vegt Prof. Dr. S. Rodenhuis Dr. L. van Velthuysen Dr. M. Schmidt Dr. S. Verhoef Dr. S. Linn Dr. M. Versleijen Prof. dr. J.Schellens L. de Wit-van der Veen Dr. W. Zwart Dr. M. Vogel Dr. J. Wesseling Dr. W. Vogel A.Yazdi Biometrics Department Dr. J. Wesseling
60 – Faculty and Staff
Dr. I.Westerveld-de Zwart S. Marchetti B. van de Wiel Dr. B. Nuijen Dr. G. Winter-Warnars F. Opdam Prof.dr. S. Rodenhuis Radiotherapy Prof.dr. J.H.M. Schellens B.M.P. Aleman Dr. C. Smorenburg Prof.dr. G.M.M.. Bartelink G. Sonke Dr. J.S.A. Belderbos Dr. N. Steeghs Dr. M. Bloemers Dr. J. Stouthard Dr. R.W. de Boer M Tesselaar Dr. E. Damen Dr. H. Van Thienen Dr. L.G.H. Dewit Dr. M. van der Weide J. van Diesen Dr. P. Elkhuizen Surgical Oncology Dr. M. Frantzen A. Aalbers Dr. Y. Van der Geld Dr. K. Ariese Dr. R.L.M. Haas Dr. M-J. Baas-Vracken Peters O. Hamming-Vrieze Dr. A. Balm Dr. W. Heemsbergen M. van der Berg Dr. U. Van der Heide Dr. M. Van Beurden Prof.dr. M. van Herk Dr. A. Bex Dr. E.P.M. Jansen Dr. M. van Beurden Dr. J. Van de Kamer P. Biewenga J. Knegjens Dr. M.W.M. van den Brekel Dr. J. Lebesque M. Brood Dr. B.J. Mijnheer D.R. Buitelaar Dr. L.M.F. Moonen S. Buma A. Navran J. ten Cate H. Peulen Dr. F. van Coevorden Dr. F. Pos Dr. M. Crijns Dr. P. Remeijer Dr. A. Doeksen Dr. N.S. Russell Dr. W. Van Driel J.G. Salverda Dr. B. Drost M. Settler K. Efthymiou Dr. C.Schneider W. van Gijn Dr. J-J. Sonke Dr. J.J. Hage Dr. J. Stroom Dr. J. van der Hage Dr. B. van Triest Dr. C. Hahn Prof. dr. M. Verheij Dr. K. Hartemink Dr. C. van Vliet-Vroegindeweij Dr. F. Hilgers Dr. F.W. Wittkämper Dr. M. Hoornweg Prof.dr. S. Horenblas Medical Oncology S. Huissoon Dr. J.W. Baars M. van Huizum Dr. P. Baas L. Hulshoff Dr. A. Bergman Dr. S. Janssens Prof.dr. J.H. Beijnen B. Karakullukcu Dr. C. Blank Dr. G. Kenter Dr. J.P. de Boer Dr. C. Keijzer Dr. W. Boogerd Dr. H. Klomp Dr. H. Boot Dr. M. Klop Dr. D. Brandsma M. Krap Dr. W. Buikhuizen Dr. K. Kuhlmann Dr. J.A.. Burgers P. Kvistborg Dr. A. Cats M. Lieshout Dr. R. van Gijn Dr. P. Lohuis Dr. C. Grootscholten Dr. C. Lok Dr. J.B.A.G. Haanen Dr. A. Lukas Dr. M. van der Heijden A.Mehta Dr. M van den Heuvel Dr. R. Meijer Dr. A. Huitema Dr. W. Meinhardt Dr. W. De Kanter Dr. O.E. Nieweg Dr. J.M. Kerst Dr. H.S.A. Oldenburg Dr. M. van Leerdam M. Piek-Hartog Dr. S.C. Linn Dr. H.G. van de Poel Dr. A. Lukas Dr. G. Relyveld
Faculty and staff - 61 B. van Rhijn B. Zupan-Kajcovski Dr. T. Ruers Dr. C. Zuur Dr. E.J.Th. Rutgers Dr. J. van Sandick Psychosocial Research and P.F.E. Schutte Epidemiology Dr. M. Scrámek Prof.dr. N.K. Aaronson Dr. L. Smeele Dr. E. Bleiker Dr. B. Tan Prof.dr. W.J. van Harten I. Vergouwe Dr. M.Hauptmann Dr. V.J. Verwaal Prof.dr. F.E. van Leeuwen Dr. M. van der Weide Dr. M.A. Rookus Dr. L.A.E. Woerdeman Dr. S. Schagen M. Wouters J. Zijlmans
62 – Faculty and Staff
VU University Medical Center
Anesthesiology Molecular Celbiology and Immunology Dr. R.S.G.M. Perez Prof.dr. R.H.J. Beelen Prof.dr. W.W.A. Zuurmond Prof.dr. G. Kraal Prof.dr. R.E. Mebius Clinical Chemistry Prof.dr. M.A. Blankenstein Nefrology Dr. C.B.M. Oudejans Dr. C.E. Douma Dr. K. Farhat Clinical Genetics Dr. S.A. Nurmohamed Dr. J.C. Dorsman Dr. C.Y. le Poole Dr. J.J.P. Gille Dr. J.W. Rüger Dr. L.P. van Hest Prof.dr. H. Joenje Neurology Prof.dr. H.E. Meijers-Heijboer Prof.dr. J.J. Heimans Dr. F.H. Menko Dr. T.J. Postma Dr. Q. Waisfisz Dr. J.C. Reijneveld Dr. J.P. de Winter Prof.dr. M.J.B. Taphoorn
Gastroenterology Neurosurgery Dr. A.A. van Bodegraven Dr. J.C. Baayen Dr. R.J.F. Felt-Bersma Dr. R.E. Feller Prof.dr. C.J.J. Mulder Dr. D.P. Noske Dr. C.M.J. van Nieuwkerk Dr. S.M. Peerdeman Prof.dr. W.P. Vandertop Hematology Dr. P.C. de Will Hamer Dr. J.M. Baalbergen Dr. T. Würdinger Dr. M.E.D. Chamuleau Dr. J. Cloos Nuclear Medicine and PET Research Dr. A.M. Dräger Dr. R. Boellaard Prof.dr. P.C. Huijgens Prof.dr. E.F.I. Comans Dr. D.E. Issa Dr. J.D.M. Herscheid Dr. J.J.W.M. Janssen Prof.dr. O.S. Hoekstra Dr. A.A. van de Loosdrecht Prof.dr. A.A. Lammertsma Prof.dr. G.J. Ossenkoppele Dr. C.F.M. Molthoff Dr. G.J. Schuurhuis Dr. P.G. Raijmakers Dr. N. Thielen Dr. A. van Schie Dr. O. Visser Dr. G.W.M. Visser Dr. J.M. Zijlstra Dr. A.D. Windhorst Dr. S. Zweegman Obstetrics and Gynaecology Medical Oncology Prof.dr. G. Kenter Dr. V.W. van Beusechem Prof.dr. E. Boven Opthalmonology Dr. H.J. Broxterman Dr. A.C. Moll Dr. J. Buter Dr. A.J.M. van den Eertwegh Oral and Maxillofacial Surgery and Pathology Prof.dr. W.R. Gerritsen Prof.dr. E. Bloemena Prof.dr. A.W. Griffioen Dr. E.A.J.M. Schulten Dr. T.D. de Gruijl Dr. K.H. Karagozoglu Dr. C.W. van der Houven van Oordt Dr. D. Hertog Dr. C.R. Jimenez Prof.dr. I. van der Waal Dr. I.R.H.M. Konings Dr. M.E. van Linde Otolaryngology/Head and Neck Surgery Prof.dr. G.J. Peters Dr. B.M. Braakhuis Prof.dr. H. Verheul Prof.dr. R.H. Brakenhoff Dr. J.J. van der Vliet Prof.dr. R. de Bree Dr. M.J.D.L. van der Vorst Prof.dr. G.A.M.S. van Dongen Dr. S.J. Erenstein-Kraay Medical Psychology Prof.dr. J.M. Festen Prof.dr. P.T. Cohen-Kettenis Prof.dr. C.R. Leemans Dr. J. Huisman Dr. R.N.P.M. Rinkel Dr. M. Klein Prof.dr. I.M. Verdonck-de Leeuw Dr. S. van Weert
Faculty and staff - 63 Dr. B. Ylstra Paediatrics Dr. J. Cloos Pulmonology Prof.dr. A.M. van Furth Dr. I. Bahce Prof.dr. G.J.L. Kaspers Dr. A. Becker Dr. M.F. Mulder Dr. J.M.A. Daniels Dr. N.A. Oeij Dr. S.M.S. Hashemi Dr. R.N. van der Plas Prof.dr. P.E. Postmus Prof.dr. A.J.P. Veerman Prof.dr. E.F. Smit Dr. T.G. Sutedja Pathology Dr. J.A.M. Beliën Radiation Oncology Dr. M.C.G. Bleeker Dr. M.R. Dahele Prof.dr. E. Bloemena Dr. P. Doornaert Dr. B.M.E. von Blomberg Dr. C.J. Haasbeek Dr. B. Carvalho Dr. M.V.M. Lafleur Dr. S.A.G.M. Cillessen Dr. F.J. Lagerwaard Prof.dr. P.J. van den Elsen Prof.dr. S. Senan Dr. F.J.A. Fijneman Prof.dr. B.J. Slotman Dr. N.C. van Grieken Dr. P. Sminia Dr. A.H. van Hattum Dr. E. Hooijberg Radiology Dr. F. van Kemenade Prof.dr. J.A. Castelijns Prof.dr. C.J.L.M. Meijer Prof.dr. G.A. Meijer Surgery Prof.dr. J.M. Middeldorp Prof.dr. J.J. Bonjer Prof.dr. W.J. Mooi Prof.dr. M.A. Cuesta Dr. S.A. Morré Dr. M. Van Egmond Dr. L. Rozendaal Prof.dr. S. Meijer Prof.dr. R.J. Scheper Dr. M.P. van den Tol Prof.dr. P.J.F. Snijders Dr. L. te Velde Dr. R.D.M. Steenbergen Dr. F.B.J.M. Thunnissen Urology Prof.dr. P. Wesseling Dr. A.A. Geldof Prof.dr. C.L. Verweij Prof.dr. R.J.A. van Moorselaar Dr. A. Vis
64 – Faculty and Staff
University of Amsterdam
Biomedical Engineering and Physics Radiotherapy Dr.ir. G.J. Streekstra Dr. J. Crezee Dr. N.A.P. Franken Cell Biology & Histology Prof.dr. C.C.E. Koning Dr. J.A. Aten Prof.dr. J.P. Medema Prof.dr. C.J.F. van Noorden Dr. L.J.A. Stalpers Prof. dr. C.R.N. Rasch Dermatology Dr. R.M. Luiten Urology Prof.dr. J.J.M.C.H. de la Rosette Experimental Internal Medicine Prof.dr.ir. H. Wijkstra Dr. C.A. Spek
Gastroenterology & Hepatology Dr. E. Dekker Prof. dr. P. Fockens Dr. K.K. Krishnadath
Genetic Metabolic Diseases Dr. A.B.P. van Kuilenburg
Human Genetics Dr. H.A.M. Geerts Dr. M. Kool Dr. L.J. Valentijn Prof.dr. R. Versteeg
Hematology Prof. dr. A. Hagenbeek Dr. A.P. Kater Dr. M.J. Kersten Prof. dr. M.H.J. van Oers
Immunology Dr. E.F. Eldering
LaserCenter Prof.dr. A.G.J.M. van Leeuwen
Medical Bioinformatics Prof. dr. A.H.C. van Kampen
Medical Oncology Prof.dr. D.J. Richel
Neurogenetics Dr. T.J.M. Hulsebos
Obstetrics and Gynaecology Prof. dr. G.G. Kenter
Paediatric Oncology Prof.dr. H.N. Caron Dr. M.A. Grootenhuis Prof. dr. L.C.M. Kremer Dr. A.B.P. van Kuilenburg
Pathology Prof. dr. C.J.M. van Noesel Prof.dr. S.T. Pals Dr. M. Spaargaren Prof. dr. M.J. van de Vijver
Faculty and staff - 65
66 – Faculty and staff Oncology Graduate School Amsterdam OOA
international visitors
annex 2
Annex 2. International visitors
Ali A., UK Oyen W.J.G., The Netherlands van Attikum H., The Netherlands Olsson A.-K., Sweden
Barrandon Y., Switzerland Pariente N., Germany Becker P., Germany Pasparakis M., Germany Béné M.C., France Pawlita M., Germany Bentires-Alj M., Switzerland Pelkmans L., Switzerland Blow J., UK Perkins A.S., UK Briggs J., Germany Proudfoot N., UK Busch T., USA Rickinson A., UK Carducci M., USA Rosenfeld N., UK Chavrier P., France Cheney R., USA Savage P., USA Cooper J., UK Sherman K., Australia Small V., Austria David U.B., Israel Smerdon S., UK ten Dijke P., The Netherlands Snyder M., USA Dimberg A., Sweden Soloway P., USA Stark A., Austria Fennell D., UK Fraser P., UK Takeda S., Japan Tarsounas M., UK Gertler F., USA Tommasino M., France Grimwade, D, UK Gundersen G., USA Vermeulen M., The Netherlands
Harris R., USA Yamamoto K., USA Herman J.G., USA Hoatlin M., USA Hodi F.S., USA Hoogenraad C. , The Netherlands
Jones Y., UK
Kjaer A., Denmark Kabiri Z., Singapore Kerbel R., Canada Kennedy R.D., UK Kerkhoven R., The Netherlands Kotelianski V., Rusland
Lahav G., USA Le Tourneau C., France van der Maarel S., The Netherlands Macara I., USA Machesky L., UK Marshall C., UK Marschall T., The Netherlands Maughan T.S., UK van der Oost J., The Netherlands van Oudenaarden A., The Netherlands
International visitors - 69
70 – International visitors Oncology Graduate School Amsterdam OOA
PhD theses completed
annex 3
Annex 3. PhD Theses completed
In 2013, 60 graduate students completed their graduate training and obtained a PhD degree. Their names, thesis titles, supervisors and institutes are listed below. The institute at which the research described in the theses was carried out is mentioned between brackets and may differ from the university where the PhD graduation took place.
Name : Adank A. (VUmc) Title : Clinical impact of breast cancer genes University : Free University Amsterdam (co)Promotors : Prof. dr. E.J. Meijers-Heijboer, Dr. Q. Waisfisz Date : 22-11-2013
Name : van den Ancker W. (VUmc) Title : Immunodiagnostics and immune surveillance in an era of evolving immunotherapeutic strategies in AML University : Free University Amsterdam (co)Promotors : Prof. dr. G.J. Ossenkoppele, Prof. dr. A.A. van de Loosdrecht, Prof. dr. T.D. de Gruijl, Dr. T.M. Westers Date : 29-11-2013
Name : Aukema E.J. (AMC) Title : Care for consequences in children treated for leukemia or brain tumor University : University of Amsterdam (co)Promotors : Prof. M.A. Grootenhuis, Prof. B.F. Last, A.Y.N. Schouten-van Meeteren, H.N. Caron Date : 17-04-2013
Name : Balzarolo M. (AMC) Title : On the TRAIL of innate immune responses. Plasmacytoid dendritic cells and beyond University : University of Amsterdam (co)Promotors : Prof. J.P. Medema, M.C. Wolkers Date : 04-09-2013
Name : Barendse R.M. (AMC) Title : Minimally invasive strategies in rectal neoplasia University : University of Amsterdam (co)Promotors : Prof. P. Fockens, Prof. W.A. Bemelman, E. Dekker, E.J.R. de Graaf Date : 20-06-2013
Name : Bierkens M. (VUmc) Title : Understanding the heterogeneity of high-grade CIN lesions. Chromosomal and epigenetic analysis University : Free University Amsterdam (co)Promotors : Prof. dr. P.J.F. Snijders , Prof. dr. C.J.L.M Meijer, Dr. R.D.M. Steenbergen Date : 22-01-2013
Name : Bosch L.J.W. (VUmc) Title : Molecular markers for colorectal cancer screening and prediction of response to therapy University : Free University Amsterdam (co)Promotors : Prof. dr. G.A. Meijer, Dr. M. van Engeland, Dr. B. Carvalho Date : 25-04-2013
PhD theses completed – 73
Name : de Bruijn M.J. (VUmc) Title : Speech quality in oral oropharyngeal cancer patients. The development and evaluation of objective speech assessment methods University : Free University Amsterdam (co)Promotors : prof. dr. I.M. Verdonck-de Leeuw, Prof. dr. C.R. Leemans, Dr. J.A. Langendijk, Dr. L. ten Bosch Date : 10-06-2013
Name : Denters M.J. (AMC) Title : Fecal immunochemical test based colorectal cancer screening University : University of Amsterdam (co)Promotors : Prof. P. Fockens, Prof. P.M.M. Bossuyt, E. Dekker Date : 13-06-2013
Name : de Sousa E Melo Felipe (AMC) Title : Colon cancer heterogeneity: stem cells, signals and subtypes University : University of Amsterdam (co)Promotors : Prof. J.P. Medema, L. Vermeulen Date : 24-09-2013
Name : Ellenbroek S. (NKI) Title : The function of Tiam1/Rac signaling in polarity and cancer. University : University of Amsterdam (co)Promotors : Prof. dr. A. Berns Date : 26-4-2013
Name Elouarat D. (NKI) Title : . Linking lipids to acetylation - Novel roles of PI(5)P and PIP4K in SIRTI regulation and development. University : University of Leiden (co)Promotors : Prof. dr. W.Moolenaar Date : 24-9-2013
Name : Fan L. (NKI) Title : Targeted therapies for malignant gliomas: novel agents, same barrier University : University Utrecht (co)Promotors : prof. dr. J. Beijnen Date : 01-03-2013
Name : Frederix F. (NKI) Title : . Disease specificv methods for economic evaluations of breast cancer therapies. University : University of Utrecht (co)Promotors : Prof. dr. J. Schellens Date : 12-6-2013
Name : Guadagnoli M. (AMC) Title : Targeting APRIL University : University of Amsterdam (co)Promotors : Prof. J.P. Medema Date : 25-06-2013
Name : Gordijn M.S. (VUmc) Title : Neuroendocrine and Psychosocial Consequences of Childhood Acute Lymphoblastic Leukemia and Lymphoma University : Free University Amsterdam (co)Promotors : Prof. dr. G.J.L. Kaspers, Prof. dr. R.J.B.J. Gemke, Dr. J. Rotteveel Date : 02-12-2013
Name : de Groot M. (VUmc) Title : Epilepsy in brain tumor patients: towards improved and personalized treatment University : Free University Amsterdam (co)Promotors : Prof. dr. J.J. Heimans. Dr. J.C. Reijneveld, Dr. E. Aronica Date : 08-02-2013
74 - PhD theses completed
Name : van Harn T. (NKI) Title : Loss of Rb proteins: consequences for cell cycle control and genome integrity (co)Promotors : Prof. dr. H.te Riele University : Free University Amsterdam Date : 17-5-2013
Name : Hausmann J. (NKI) Title : Structural and biochemical characterization of autotaxin (co) Promotors : Prof.dr.W.Moolenaar University: University of Leiden Date : 18-4-2013
Name : Hogenbirk M. (NKI) Title : Defining risk factors for genomic instability in B cells - novel insights from NGS-based technologies University : University of Amsterdam (co)Promotors : Prof. dr. A.Berns Date : 26-11-2013
Name : Hoogeboom R. (AMC) Title : The role of antigen in the development of B-cell chronic lymphocytic leukemia University : University of Amsterdam (co)Promotors : Prof. C.J.M. van Noesel, R.J. Bende Date : 08-05-2013
Name : Hooijkaas A. (NKI) Title : Preclinical optimization of melanoma treatment University : University of Leiden (co)Promotors : Prof. dr. T.Schumacher Date : 13-6-2013
Name : Iusuf D. (NKI) Title : Drug trafficking in mice: in vivo functions of OATP uptake and ABC efflux transporters University : University of Utrecht (co)Promotors : Prof. dr. J. Beijnen Date : 11-9-2013
Name : Jaspers J. (NKI) Title : Targeting anti-cancer drug resistance in mouse models of breast cancer. University : University of Utrecht (co)Promotors : Prof. dr. R. Medema Date : 12-11-2013
Name : van der Kant R. (NKI) Title : Cholestrol and multi-protein complexes in the control of late endosomal dynamic University : University of Leiden (co)Promotors : Prof.dr.J. Neefjes Date : 26-9-2013
Name: Knijnenburg S.L. (AMC) Title : Late effects of childhood cancer. Epidemiology and patient education University : University of Amsterdam (co)Promotors : Prof. M.W.M. Jaspers, Prof. H.N. Caron Date : 29-05-2013
Name : Kuiper T. (AMC) Title : Advancements in colorectal imaging. Towards more accurate and efficient colonoscopies University : University of Amsterdam (co)Promotors : Prof. P. Fockens, E. Dekker Date : 25-01-2013
PhD theses completed – 75
Name: Leijen S. (NKI) Title : Development of combination therapy with anti-cancer drugs. University : University of Utrecht (co)Promotors : Prof. dr. J. Schellens Date : 15-3-2013
Name : Linnemann C. (NKI) Title : Engineering T cell immunity by TCR gene transfer. University : University of Leiden (co)Promotors : Prof. dr. T. Schumacher Date : 27-11-2013
Name : Margadant C. (NKI) Title : Regulation of integrin function and trafficking University: University of Amsterdam (co)Promotors : Prof. dr. A. Berns Date : 29-1-2013
Name : Mattiroli F. (NKI) Title : Understanding the mechanism of histone 2A ubiquitination (co)Promotors : Prof. dr. T.Sixma University : Erasmus University Rotterdam Date : 4-4-2013
Name : Meulenaar J. (NKI) Title : Development of an oral dosage form of capecitabine with modified release characteristics University : University of Utrecht (co)Promotors : Prof. dr. J. Schellens Date : 25-9-2013
Name Moes J. (NKI) Title : Development and clinical application of oral dosage forms of taxanes University : University of Utrecht (co)Promotors : Prof. dr. J. Schellens / J. Beijnen Date : 30-10-2013
Name Mulder R.L. (AMC) Title : Optimization of care for survivors of childhood cancer University : University of Amsterdam (co)Promotors : Prof. H.N. Caron, L.C.M. Kremer, E.C. van Dalen Date : 03-04-2013
Name : Pang B. (NKI) Title : . Understanding immunotherapy and chemotherapy - New way of antigen cross- presentation and novel anti-tumor effects by doxorubicin. University : University of Leiden (co)Promotors : Prof. dr. J. Neefjes Date : 28-5-2013
Name : Peuscher M. (NKI) Title : Identification of novel factors controlling DNA damage responses at uncapped telomeres University : University of Amsterdam (co)Promotors : Prof. dr. A. Berns Date : 7-6-2013
Name : Phernambucq E.C.J. (VUmc) Title : Combined Modality Treatment for Locally-Advanced Non-Small-Cell Lung Cancer: The ongoing search for optimal management University : Free University Amsterdam (co)Promotors : Prof. dr. E.F. Smit, Prof. dr. S. Senan Date : 01-07-2013
76 - PhD theses completed
Name : de Ronde J. (NKI) Title : The quest for biomarkers: computataional exploration of the cancer genome University : University of Amsterdam (co)Promotors : Prof. dr. S. Rodenhuis Date : 2-7-2013
Name : Rijkaart D.C. (VUmc) Title : Impact of HPV testing on cervical cancer screening University : Free University Amsterdam (co)Promotors : Prof. dr. C.J.L.M. Meijer, Prof. dr. P.J.F. Snijders, Dr. D.A.M. Heideman, Dr. J. Berkhof J Date : 01-03-2013
Name : Rooswinkel R. (NKI) Title : Targeting anti-apoptotic Bcl-2 proteins in cancer. The importance of intermolecular interactions and protein turnover University : University of Amsterdam (co)Promotors : Prof. dr. M.Verheij Date : 15-2-2013
Name : Sachs N. (NKI) Title : The role of CD151 and integrin in the pathophysiologyf kidney and skin University : University of Amsterdam (co)Promotors : Prof. dr. A. Berns Date : 14-4-2013
Name : Scherpenisse M. (VUmc) Title : The humoral immune responses after HPV infection and prophylactic vaccination: Importance of serology University : Free University Amsterdam (co)Promotors : Prof. dr. C.J.L.M. Meijer, Dr. F.R.M. van der Klis, Dr. G.A.M. Berbers, Dr. D.P. Noske Date : 17-10-2013
Name : Sieswerda E. (AMC) Title : Childhood cancer survivors: evidence & care University : University of Amsterdam (co)Promotors : Prof. dr. M. Verheij Date : 15-2-2013
Name : Stegeman I. (AMC) Title : Risk profiling and screening for colorectal cancer University : University of Amsterdam (co)Promotors : Prof. P.M.M. Bossuyt, E. Dekker, R.A. Kraaijenhagen Date : 02-10-2013
Name : Swellengrebel M. (NKI) Title : Challenges in the multimodality treatment of rectal cancer. University : University of Leiden (co)Promotors : Prof. dr. C.Marijnen Date : 23-10-2013
Name : Smit J.J. (NKI) Title : Ubiquitin chanin formation by RBR E3-ligases (co)Promotors : Prof. dr. T.Sixma University : Erasmus University Rotterdam Date : 28-5-2013
Name : Stuurman R. (NKI) Title : Clinical pharmacology of novel anticancer drug formulations. University : University of Utrecht (co)Promotors : Prof. dr. J. Schellens Date : 18-9-2013
PhD theses completed – 77
Name : Tang S.C. (NKI) Title : Impact if apical ABC transporters on pharmacokinetics of targeted anticancer drugs. University : University of Leiden (co)Promotors : Prof. dr. J. Neefjes Date : 28-5-2013
Name : Terweij M. (NKI) Title : Investigating epigenome dynamics the RITE way University : University of Amsterdam (co)Promotors : Prof. dr. M.Lohuizen Date : 5-11-2013
Name : Terwijn M. (VUmc) Title : Minimal Residual Disease and Leukemic Stem Cell Detection in Acute Myeloid Leukemia: New Approaches for Clinical Decision Making University : Free University Amsterdam (co)Promotors : Prof. dr. G.J. Ossenkoppele, Dr. G.J. Schuurhuis Date : 12-04-2013
Name : Turksma A.W. (VUmc) Title : Preclinical studies on immunotherapeutic approaches for the treatment of solid tumors University : Free University Amsterdam (co)Promotors : Prof. dr. C.J.L.M. Meijer, Prof. dr. C.R. Leemans, Dr. E. Hooijberg, Dr. E. Bloemena Date : 21-11-2013
Name : van der Velden Y. (NKI) Title : Two proteins, One model organism. On the functional characterization of Lkb1 and Ring1b in zebrafish University : University of Amsterdam (co)Promotors : Prof. dr. M.van Lohuizen Date: 1-3-2013
Name : Verloop J. (NKI) Title : Long-term health effects after DES exposure in utero. University : Free University Amsterdam (co)Promotors : Prof.dr. F.van Leeuwen Date : 20-3-2013
Name : Voorham Q.J.M. (VUmc) Title : Molecular Characterization of Nonpolypoid Colorectal Adenomas University : Free University Amterdam (co)Promotors : Prof. dr. G.A. Meijer, Prof. dr. C.J.J. Mulder, Dr. B. Carvalho, Dr. M. van Engeland Date : 12-09-2013
Name : de Wijkerslooth T. (AMC) Title : Population screening for colorectal cancer by colonoscopy (co)Promotors : Prof. P. Fockens, Prof. P.M.M. Bossuyt University : University of Amsterdam Date : 07-03-2013
Name : Wildeman M. (NKI) Title : Current problems and possible solutions in the treatment of Nasopharyngeal Carcinoma in Indonesia. University : University of Amsterdam (co)Promotors : Prof. dr. A.Balm Date : 7-2-2013
Name : Wilting R. (NKI) Title : Inactivate the two-faced HDAC-brake - Cell cycle regulation and tumor suppression by histone deacetylases HDAC1 and HDAC2. University : University of Amsterdam (co)Promotors : Prof. dr. M. Lohuizen Date : 13-11-2013
78 - PhD theses completed
Name : Wit N. (NKI) Title : Modifications of DNA clamps and their role in DNA damage management University : University of Amsterdam (co)Promotors : Prof. dr. J.Borst Date : 1-7-2013
Name : de Wit M. (VUmc) Title : Protein biomarkers for clinical application in colorectal cancer University : Free University Amsterdam (co)Promotors : Prof. dr. G.A. Meijer, Dr. R.J.A. Fijneman, Dr. C.R. Jimenez Date : 04-10-2013
Name : Zander S. (NKI) Title : Resistance to topoisomerase inhibitors in BRCA-1-deficient mouse mammary tumors University : Free University Amsterdam (co)Promotors : Prof. dr. H. te Riele Date : 25-1-2013
PhD theses completed – 79
80 - PhD theses completed Oncology Graduate School Amsterdam OOA
scientific publications
annex 4
Annex 4. Scientific publications
1. Aalbers AM, Calado RT, Young NS, Zwaan CM, Kajigaya S, Baruchel A, Geleijns K, de Haas V, Kaspers GJL, Reinhardt D, Trka J, Kuijpers TW, Pieters R, van der Velden VHJ, van den Heuvel-Eibrink MM. Absence of SBDS mutations in sporadic paediatric acute myeloid leukaemia. Brit J Haematol 2013; 160: 559-561. (VUmc) 2. Aalbers AM, Calado RT, Young NS, Zwaan CM, Wu C, Kajigaya S, Coenen EA, Baruchel A, Geleijns K, de Haas V, Kaspers GJL, Kuijpers TW, Reinhardt D, Trka J, Zimmermann M, Pieters R, van der Velden VHJ, van den Heuvel-Eibrink MM. Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia. Leukemia 2013; 27: 1786-1789. (VUmc) 3. Aalbers AM, van den Heuvel-Eibrink MM, de Haas V, te Marvelde JG, de Jong AX, van der Burg M, Dworzak M, Hasle H, Locatelli F, De Moerloose B, Schmugge M, Stary J, Zecca M, Zwaan CM, van de Loosdrecht AA, van Dongen JJM, Niemeyer CM, van der Velden VHJ. Applicability of a reproducible flow cytometry scoring system in the diagnosis of refractory cytopenia of childhood. Leukemia 2013; 27: 1923-1925. (VUmc) 4. Aan de Kerk DJ, van Leeuwen EMM, Jansen MH, van den Berg JM, Alders M, Vermont CL, van Lier RAW, Pals ST, Kuijpers TW. Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis. Clinical Immunology 2013 149(1), 2013, p.25-31. (AMC) 5. Aarntzen EH, De Vries IJ, Lesterhuis WJ, Schuurhuis D, Jacobs JF, Bol K, Schreibelt G, Mus R, de Wilt JH, Haanen JB, Schadendorf D, Croockewit A, Blokx WA, Van Rossum MM, Kwok WW, Adema GJ, Punt CJ, Figdor CG. Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination. Cancer Res 2013; 73:19-29 (AMC/NKI) 6. Aarntzen EHJG, Srinivas M, Bonetto F, Cruz LJ, Verdijk P, Schreibelt G, van de Rakt M, Lesterhuis WJ, van Riel M, Punt CJA, Adema GJ, Heerschap A, Figdor Carl G, Oyen WJ, de Vries IJM. Targeting of 111In-Labeled Dendritic Cell Human Vaccines Improved by Reducing Number of Cells. Clinical Cancer Research 2013 19(6), 2013, p.1525-1533. (AMC) 7. Aarntzen EHJG, Srinivas M, Radu CG, Punt CJA, Boerman OC, Figdor CG, Oyen WJG, de Vries IJM. In vivo imaging of therapy-induced anti-cancer immune responses in humans. Cellular and Molecular Life Sciences 2013 70(13), 2013, p.2237-2257. (AMC) 8. Aarntzen EHJG, Srinivas M, Schreibelt G, Heerschap A, Punt CJA, Figdor CG, Oyen WJ, de Vries IJM. Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination. Oncoimmunology 2(7), 2013, p.e24661-. (AMC) 9. Aarts MJ, Grutters JP, Peters FP, Mandigers CM, Dercksen MW, Stouthard JM, Nortier HJ, van Laarhoven HW, van Warmerdam LJ, van de Wouw AJ, Jacobs EM, Mattijssen V, van der Rijt CC, Smilde TJ, van der Velden AW, Temizkan M, Batman E, Muller EW, van Gastel SM, Joore MA, Borm GF, Tjan-Heijnen VC. Cost effectiveness of primary pegfilgrastim prophylaxis in patients with breast cancer at risk of febrile neutropenia. Journal of clinical oncology 2013 31(34), 2013, p.4283-4289. (AMC) 10. Aarts MJ, Peters FP, Mandigers CM, Dercksen MW, Stouthard JM, Nortier HJ, van Laarhoven HW, van Warmerdam LJ, van de Wouw AJ, Jacobs M, Mattijssen V, van der Rijt CC, Smilde TJ, van der Velden AW, Temizkan M, Batman E, Muller EW, van Gastel SM, Borm GF, Tjan-Heijnen VCG.: Primary granulocyte colony-stimulating factor prophylaxis during the first two cycles only or throughout all chemotherapy cycles in patients with breast cancer at risk for febrile neutropenia. Journal of Clinical Oncology 31(34), 2013, p.4290-4296. (AMC) 11. Abis GSA, Stockmann HBAC, van Egmond M, Bonjer HJ, Vandenbroucke-Grauls CMJE, Oosterling SJ. Selective Decontamination of the Digestive Tract in Gastrointestinal Surgery: Useful in Infection Prevention? A Systematic Review. J Gastrointest Surg 2013; 17: 2172-2178. (VUmc) 12. Abouyahya I, Alhan C, Westers TM, te Boekhorst PA, Kappers-Klunne MC, Coenen JL, Heyning FH, Huls GA, de Wolf JT, Imholz AL, Koene HR, Veth G, de Kruijf EJFM, Muus P, Planken EV, Segeren CM, Vasmel WL, van der Velden AM, Velders GA, Koedam J, Ossenkoppele GJ, van de Loosdrecht AA. Treatment with lenalidomide in myelodysplastic syndromes with deletion 5q: results from the Dutch named patient program. Leukemia Lymphoma 2013; 54: 874-877. (VUmc) 13. Adams HJA, Kwee TC, Vermoolen MA, de Keizer B, de Klerk JMH, Adam JA, Fijnheer R, Kersten MJ, Stoker J, Nievelstein RAJ. Whole-body MRI for the detection of bone marrow involvement in lymphoma: prospective study in 116 patients and comparison with FDG-PET. European Radiology 23(8), 2013, p.2271-2278. (AMC) 14. Adank MA, Verhoef S, Oldenburg RA, Schmidt MK, Hooning MJ, Martens JW, Broeks A, Rookus M, Waisfisz Q, Witte BI, Jonker MA, Meijers-Heijboer H. Excess breast cancer risk in first degree relatives of CHEK2 *1100delC positive familial breast cancer cases. Eur J Cancer 2013; 49:1993-9 (AMC/NKI/VUmc)
Scientific publications - 83
15. Ades F, de Azambuja E, Daugaard G, Ameye L, Moulin C, Paesmans M, De Jong D, Decoster L, De Greve J, Ismael G, Moller AK, Piccart M, Awada A. Comparison of a gene expression profiling strategy to standard clinical work-up for determination of tumour origin in cancer of unknown primary (CUP). J Chemother 2013; 25:239-46 (NKI/VUmc) 16. Adham M, Greijer A, Verkuijlen S, Juwana H, Fleig S, Rachmadi L, Malik O, Kurniawan AN, Roezin A, Gondhowiardjo S, Atmakusumah D, Stevens S, Hermani B, Tan IB, Middeldorp J. Epstein-Barr virus DNA load in nasopharyngeal brushings and whole blood in nasopharyngeal carcinoma patients before and after treatment. Clin Cancer Res 2013; 19:2175-86 (NKI/VUmc) 17. Adriaanse MPM, Tack GJ, Passos VL, Damoiseaux JGMC, Schreurs MWJ, van Wijck K, Riedl RG, Masclee AAM, Buurman WA, Mulder CJJ, Vreugdenhil ACE. Serum I-FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies. Aliment Pharm Therap 2013; 37: 482-490. (VUmc) 18. Aerts JG, Codrington H, Lankheet NAG, Burgers S, Biesma B, Dingemans A-MC, Vincent AD, Dalesio O, Groen HJM, Smit EF. A randomized phase II study comparing erlotinib versus erlotinib with alternating chemotherapy in relapsed non-small-cell lung cancer patients: the NVALT-10 study. Ann Oncol 2013; 24:2860-5 (NKI/VUmc) 19. Aggarwal C, Meropol NJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, Picus J, Morse MA, Mitchell E, Miller MC, Cohen SJ. Relationship among circulating tumor cells, CEA and overall survival in patients with metastatic colorectal cancer. Annals of Oncology 24(2), 2013, p.420-428. (AMC) 20. Ahmed AU, Issa Y, Bruno MJ, van Goor H, van Santvoort H, Busch ORC, Dejong CHC, Nieuwenhuijs VB, van Eijck CH, van Dullemen HM, Fockens P, Siersema PD, Gouma DJ, van Hooft JE, Keulemans Y, Poley JW, Timmer, Besselink MG, Vleggaar FP, Wilder-Smith OH, Gooszen HG, Dijkgraaf MGW, Boermeester MA. Early surgery versus optimal current step-up practice for chronic pancreatitis (ESCAPE): design and rationale of a randomized trial. BMC Gastroenterology 13(1), 2013, p.49-. (AMC) 21. Ahmed AU, van der Sluis PC, Issa Y, Habaga IA, Gooszen HG, Flum DR, Algra A, Besselink MG: Trends in Worldwide Volume and Methodological Quality of Surgical Randomized Controlled Trials. Annals of Surgery 258(2), 2013, p.199-207. (AMC) 22. Akhtar W, de Jong J, Pindyurin A, Pagie L, Meuleman W, de Ridder J, Berns A, Wessels L, van Lohuizen M, van Steensel B. Chromatin position effects assayed by thousands of reporters integrated in parallel. Cell 2013; 154:914-27 (NKI) 23. Alberts VP, Minnee RC, van Donselaar-van der Pant KAMI, Bemelman FJ, Zondervan PJ, Laguna Pes MP, Idu MM. Duplicated ureters and renal transplantation: a case-control study and review of the literature. Transplantation Proceedings 45(9), 2013, p.3239-3244. (AMC) 24. Albrethsen J, Agner J, Piersma SR, Hojrup P, Pham TV, Weldingh K, Jimenez CR, Andersen P, Rosenkrands I. Proteomic Profiling of Mycobacterium tuberculosis Identifies Nutrient-starvation- responsive Toxin-antitoxin Systems. Mol Cell Proteomics 2013; 12: 1180-1191. (VUmc) 25. Alderlieste YA, Bastiaansen BA, Mathus-Vliegen EMH, Gouma DJ, Dekker E. "High rate of recurrent adenomatosis during endoscopic surveillance after duodenectomy in patients with familial adenomatous polyposis". Familial Cancer 12(4), 2013, p.699-706. (AMC) 26. Alderlieste YA, Rauws EAJ, Mathus-Vliegen EMH, Fockens P, Dekker E. Prospective enteroscopic evaluation of jejunal polyposis in patients with familial adenomatous polyposis and advanced duodenal polyposis. Familial Cancer 12(1), 2013, p.51-56. (AMC) 27. Alderliesten T, Betgen A, Elkhuizen PHM, van Vliet-Vroegindeweij C, Remeijer P. Estimation of heart-position variability in 3D-surface-image-guided deep-inspiration breath-hold radiation therapy for left-sided breast cancer. Radiotherapy and Oncology 109(3), 2013, p.442-447. (AMC/NKI) 28. Alderliesten T, Sonke J-J, Betgen A, Honnef J, van Vliet-Vroegindeweij C, Remeijer P. Accuracy evaluation of a 3-dimensional surface imaging system for guidance in deep-inspiration breath-hold radiation therapy. International Journal of Radiation Oncology Biology Physics 85(2), 2013, p.536-542. (AMC/NKI) 29. Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SAJR, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale A-L, Boyault S, Burkhardt B, Butler AP, Caldas C, Davies HR, Desmedt C, Eils R, Eyfjörd JE, Foekens JA, Greaves M, Hosoda F, Hutter B, Ilicic T, Imbeaud S, Imielinsk M, Jäger N, Jones DTW, Jones D, Knappskog S, Kool M, Lakhani SR, López-Otín C, Martin S, Munshi NC, Nakamura H, Northcott PA, Pajic M, Papaemmanuil E, Paradiso A, Pearson JV, Puente XS, Raine K, Ramakrishna M, Richardson AL, Richter J, Rosenstiel P, Schlesner M, Schumacher TN, Span PN, Teague JW, Totoki Y, Tutt ANJ, Valdés-Mas R, van Buuren MM, van 't Veer L, Vincent-Salomon A, Waddell N, Yates LR, Zucman-Rossi J, Futreal PA, McDermott U, Lichter P, Meyerson M, Grimmond SM, Siebert R, Campo E, Shibata T, Pfister SM, Campbell PJ, Stratton MR. Signatures of mutational processes in human cancer. Nature 500(7463), 2013, p.415-421. (AMC/NKI) 30. Alexiusdottir KK, Snaebjornsson P, Tryggvadottir L, Jonasson L, Olafsdottir EJ, Bjornsson ES, Moller PH, Jonasson JG. Colon cancer: association of histopathological parameters and patients' survival with clinical presentation. APMIS Acta pathologica, microbiologica et immunologica Scandinavica 2013; 121: 901-907. (VUmc) 31. Allaart CF, Lems WF, Huizinga TWJ. The BeSt way of withdrawing biologic agents. Clin Exp Rheumatol 2013; 31: S14-S18. (VUmc)
84 - Scientific publications
32. Alvarez Herrero L, Curvers WL, van Vilsteren FGI, Wolfsen H, Ragunath K, Wong Kee Song L-M, Mallant-Hent RC, van Oijen A, Scholten P, Schoon EJ, Schenk EBE, Weusten BLAM, Bergman JGHM. Validation of the Prague C&M classification of Barrett's esophagus in clinical practice. Endoscopy 45(11), 2013, p.876-882. (AMC) 33. Alvarez-Fernandez M, Medema RH. Novel functions of FoxM1: from molecular mechanisms to cancer therapy. Front Oncol 2013; 3:30 (NKI) 34. Alvi MA, Liu X, O'Donovan M, Newton R, Wernisch L, Shannon NB, Shariff K, Di Pietro M, Bergman JJGHM, Ragunath K, Fitzgerald RC. DNA methylation as an adjunct to histopathology to detect prevalent, inconspicuous dysplasia and early-stage neoplasia in Barrett's esophagus. Clinical Cancer Research 19(4), 2013, p.878-888. (AMC) 35. Amant F, von Minckwitz G, Han S, Bontenbal M, Ring A, Giermek J, Wildiers H, Fehm T, Linn S, Schlehe B, Neven P, Westenend P, Muller V, Van Calsteren K, Rack B, Nekljudova V, Harbeck N, Untch M, Witteveen P, Schwedler K, Thomssen C, Van Calster B, Loibl S. Prognosis of women with primary breast cancer diagnosed during pregnancy: results from an international collaborative study. J Clin Oncol 2013; 31:2532-9 (NKI) 36. Ammerlaan HSM, Harbarth S, Buiting AGM, Crook DW, Fitzpatrick F, Hanberger H, Herwaldt LA, van Keulen PHJ, Kluijtmans JAJW, Kola A, Kuchenbecker RS, Lingaas E, Meessen N, Morris-Downes MM, Pottinger JM, Rohner P, dos Santos RP, Seifert H, Wisplinghoff H, Ziesing S, Walker AS, Bonten MJM. Secular Trends in Nosocomial Bloodstream Infections: Antibiotic-Resistant Bacteria Increase the Total Burden of Infection. Clin Infect Dis 2013; 56: 798-805. (VUmc) 37. Amore A, Wals K, Koekoek E, Hoppes R, Toebes M, Schumacher TN, Rodenko B, Ovaa H. Development of a hypersensitive periodate-cleavable amino acid that is methionine- and disulfide-compatible and its application in MHC exchange reagents for T cell characterisation. Chembiochem 2013; 14:123-31 (NKI) 38. Anastasiadis A, Zapała L, Cordeiro E, Antoniewicz A, Dimitriadis G, de Reijke T. Complications of prostate biopsy. Expert review of anticancer therapy 13(7), 2013, p.829-837. (AMC) 39. Andersen CL, McMullin MF, Ejerblad E, Zweegman S, Harrison C, Fernandes S, Bareford D, Knapper S, Samuelsson J, Lofvenberg E, Linder O, Andreasson B, Ahlstrand E, Jensen MK, Bjerrum OW, Vestergaard H, Larsen H, Klausen TW, Mourits-Andersen T, Hasselbalch HC. A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia. Brit J Haematol 2013; 162: 498- 508. (VUmc) 40. Andersson J, Angenete E, Gellerstedt M, Angeras U, Jess P, Rosenberg J, Furst A, Bonjer HJ, Haglind E. Health-related quality of life after laparoscopic and open surgery for rectal cancer in a randomized trial. Brit J Surg 2013; 100: 941-949. (VUmc) 41. Andeweg CS, Mulder IM, Felt-Bersma RJF, Verbon A, van der Wilt GJ, van Goor H, Lange JF, Stoker J, Boermeester MA, Bleichrodt RP. Guidelines of Diagnostics and Treatment of Acute Left-Sided Colonic Diverticulitis. Digestive Surgery 2013; 30: 278-229. (VUmc) 42. Arnold M, Wildeman MA, Visser O, Karim-Kos HE, Middeldorp JM, Fles R, Bing Tan I, Coebergh JW. Lower mortality from nasopharyngeal cancer in The Netherlands since 1970 with differential incidence trends in histopathology. Oral Oncol 2013; 49:237-43 (NKI/Vumc) 43. Arranz E, Pena AS, Bernardo D. Mediators of Inflammation and Immune Responses in the Human Gastrointestinal Tract. Mediat Inflamm 2013; : 865638. (VUmc) 44. Arteaga de Castro CS, Boer VO, Andreychenko A, Wijnen JP, van der Heide UA, Luijten PR, Klomp DWJ. Improved efficiency on editing MRS of lactate and +¦-aminobutyric acid by inclusion of frequency offset corrected inversion pulses at high fields. NMR Biomed 2013; 26:1213-9 (NKI) 45. Ascierto PA, Schadendorf D, Berking C, Agarwala SS, van Herpen CML, Queirolo P, Blank CU, Hauschild A, Beck JT, St Pierre A, Niazi F, Wandel S, Peters M, Zubel A, Dummer R. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A non-randomised, open-label phase 2 study. Lancet Oncol 2013; 14:249-56 (NKI) 46. Assink-de Jong E, Groeneveld ABJ, Pettersson AM, Koek A, Vandenbroucke-Grauls CMJE, Beishuizen A, Simoons-Smit AM. Clinical correlates of herpes simplex virus type 1 loads in the lower respiratory tract of critically ill patients. J Clin Virol 2013; 58: 79-83. (VUmc) 47. Atai NA, Balaj L, van Veen H, Breakefield XO, Jarzyna PA, van Noorden CJF, Skog J, Maguire CA.:Heparin blocks transfer of extracellular vesicles between donor and recipient cells. 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51. Avan A, Caretti V, Funel N, Galvani E, Maftouh M, Honeywell RJ, Lagerweij T, van Tellingen O, Campani D, Fuchs D, Verheul HM, Schuurhuis GJ, Boggi U, Peters GJ, Wurdinger T, Giovannetti E. Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma. Cancer Res 2013; 73:6745-56 (NKI/VUmc) 52. Avan A, Maftouh M, Giovannetti E. An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross- complementing gene-1 expression in patients with resected pancreas adenocarcinoma: Implications for adjuvant treatment. Cancer 2013; 119: 2662-2663. (VUmc) 53. Avan A, Pacetti P, Reni M, Milella M, Vasile E, Mambrini A, Vaccaro V, Caponi S, Cereda S, Peters GJ, Cantore M, Giovannetti E. Prognostic factors in gemcitabine-cisplatin polychemotherapy regimens in pancreatic cancer: XPD-Lys751Gln polymorphism strikes back. Int J Cancer 2013; 133: 1016-1022. (VUmc) 54. 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272. Corso G, Carvalho J, Marrelli D, Vindigni C, Carvalho B, Seruca R, Roviello F, Oliveira C. Somatic Mutations and Deletions of the E-Cadherin Gene Predict Poor Survival of Patients With Gastric Cancer. J Clin Oncol 2013; 31: 868-875. (VUmc) 273. Cortes A, Hadler J, Pointon JP, Robinson PC, Karaderi T, Leo P, Cremin K, Pryce K, Harris J, Lee S, Joo KB, Shim SC, Weisman M, Ward M, Zhou XD, Garchon HJ, Chiocchia G, Nossent J, Lie BA, Forre O, Tuomilehto J, Laiho K, Jiang L, Liu Y, Wu X, Bradbury LA, Elewaut D, Burgos-Vargas R, Stebbings S, Appleton L, Farrah C, Lau J, Kenna TJ, Haroon N, Ferreira MA, Yang J, Mulero J, Fernandez-Sueiro JL, Gonzalez-Gay MA, Lopez-Larrea C, Deloukas P, Donnelly P, Bowness P, Gafney K, Gaston H, Gladman DD, Rahman P, Maksymowych WP, Xu HJ, Crusius JBA, van der Horst-Bruinsma IE, Chou CT, Valle-Onate R, Romero-Sanchez C, Hansen IM, Pimentel-Santos FM, Inman RD, Videm V, Martin J, Breban M, Reveille JD, Evans DM, Kim TH, Wordsworth BP, Brown MA. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet 2013; 45: 730-738. (VUmc)
274. Cosentino M, Breda A, Sanguedolce F, Landman J, Stolzenburg J-U, Verze P, Rassweiler J, van Poppel H, Klingler HC, Janetschek G, Celia A, Kim FJ, Thalmann G, Nagele U, Mogorovich A, Bolenz C, Knoll T, Porpiglia F, Alvarez-Maestro M, Francesca F, Deho F, Eggener S, Abbou C, Meng MV, Aron M, Laguna P, Mladenov D, D'Addessi A, Bove P, Schiavina R, de Cobelli O, Merseburger AS, Dalpiaz O, D'Ancona FCH, Polascik TJ, Muschter R, Leppert TJ, Villavicencio H. The use of mannitol in partial and live donor nephrectomy: an international survey. World Journal of Urology 31(4), 2013, p.977-982. (AMC) 275. Coskun M, Straube W, Hurkmans CW, Melidis C, de Haan PF, Villa S, Collette S, Weber DC. Quality assurance of radiotherapy in the ongoing EORTC 22042-26042 trial for atypical and malignant meningioma: results from the dummy runs and prospective individual case Reviews. Radiat Oncol 2013; 8: 23. (VUmc) 276. Cote CH, Bouchard P, van Rooijen N, Marsolais D, Duchesne E. Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury. BMC Musculoskel Dis 2013; 14: . (VUmc) 277. Couch FJ, Antoniou AC et all. Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLOS Genetics 9(3), 2013, p.e1003212-. (AMC/NKI/VUmc) 278. Crijns W, Maes F, van der Heide UA, Van den Heuvel F. Calibrating page sized Gafchromic EBT3 films. Med Phys 2013; 40:012102 (NKI) 279. Crosby K, Postma M, Hink M, Zeelenberg C, Adjobo-Hermans M, Gadella T. Quantitative analysis of self- association and mobility of annexin A4 at the plasma membrane. Biophys J 2013; 104:1875-85 (NKI) 280. Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T, Mirkov MU, Canhao H, Ikari K, Terao C, Okada Y, Wedren S, Askling J, Yamanaka H, Momohara S, Taniguchi A, Ohmura K, Matsuda F, Mimori T, Gupta N, Kuchroo M, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Herenius M, Doorenspleet ME, Tak PP, Crusius JBA, van der Horst-Bruinsma IE, Wolbink GJ, van Riel PLCM, van de Laar M, Guchelaar HJ, Shadick NA, Allaart CF, Huizinga TWJ, Toes REM, Kimberly RP, Bridges SL, Criswell LA, Moreland LW, Fonseca JE, de Vries N, Stranger BE, de Jager PL, Raychaudhuri S, Weinblatt ME, Gregersen PK, Mariette X, Barton A, Padyukov L, Coenen MJH, Karlson EW, Plenge RM. Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis. PLoS Genet 2013; 9: 3. (VUmc) 281. da Rocha DS, Salmonson T, van Zwieten-Boot B, Jonsson B, Marchetti S, Schellens JHM, Giuliani R, Pignatti F. The European Medicines Agency review of vemurafenib (Zelboraf(R)) for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma: summary of the scientific assessment of the Committee for Medicinal Products for Human Use. Eur J Cancer 2013; 49:1654-61 (NKI) 282. Dahele MR, Senan S. What causes early mortality in patients with large tumors receiving radical chemo- radiotherapy for non-small cell lung cancer? In response to Ball et al. Radiather Oncol 2013; 109: 179- 180. (VUmc) 283. Dahhan T, Balkenende E, van Wely M, Linn S, Goddijn M. Tamoxifen or letrozole versus standard methods for women with estrogen-receptor positive breast cancer undergoing oocyte or embryo cryopreservation in assisted reproduction. Cochrane Database Syst Rev 2013; 11:CD010240 (NKI) 284. Dall'Angelo S, Bandaranayaka N, Windhorst AD, Vugts DJ, van der Born D, Onega M, Schweiger LF, Zanda M, O'Hagan D. Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[F- 18]fluoro-5-deoxyribose as a novel tracer. Nucl Med Biol 2013; 40: 464-470. (VUmc) 285. Damhofer H, Medema JP, Veenstra VL, Badea L, Popescu I, Roelink H, Bijlsma MF. Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma. Molecular Oncology 7(6), 2013, p.1031-1042. (AMC) 286. Daniels JMA, Sutedja TG. Detection and minimally invasive treatment of early squamous lung cancer. Ther Adv Med Oncol 2013; 5: 235-248. (VUmc) 287. Daniëls LA, Krol ADG, Schaapveld M, Putter H, Jansen PM, Marijt EWA, van Leeuwen FE, Creutzberg CL. Long-term risk of secondary skin cancers after radiation therapy for Hodgkin's lymphoma. Radiother Oncol 2013; 109:140-5 (NKI) 288. Das S, Bryan K, Buckley PG, Piskareva O, Bray IM, Foley N, Ryan J, Lynch J, Creevey L, Fay J, Prenter S,
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Koster J, van Sluis P, Versteeg R, Eggert A, Schulte JH, Schramm A, Mestdagh P, Vandesompele J, Speleman F, Stallings RL. Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs. Oncogene 32(24), 2013, p.2927-2936. (AMC) 289. Datema FR, Bran GM, Koot VCM, Lohuis PJFM. Management of an epidermoid cyst in the nasal tip of a child: aesthetic and surgical considerations. J Laryngol Otol 2013; 127:1028-30 (NKI) 290. Davies A, Buchanan A, Zeppetella G, Porta-Sales J, Likar R, Weismayr W, Slama O, Korhonen T, Filbet M, Poulain P, Mystakidou K, Ardavanis A, O'Brien T, Wilkinson P, Caraceni A, Zucco F, Zuurmond W, Andersen S, Damkier A, Vejlgaard T, Nauck F, Radbruch L, Sjolund KF, Stenberg M. Breakthrough Cancer Pain: An Observational Study of 1000 European Oncology Patients. J Pain Symptom Manag 2013; 46: 619- 628. (VUmc) 291. De Boer J, van Herk M, Pos FJ., Sonke J-J: Hybrid registration of prostate and seminal vesicles for image guided radiation therapy. International Jouranl of Radiation Oncology and Biology Physics 86(1), 2013, p.177-182. (AMC/NKI) 292. de Boer KHN, de Meij T, van Bodegraven AA. Thiopurines during pregnancy in inflammatory bowel disease: is there a risk for the (unborn) child?. Expert Review of Gastroenterology & Hepatology 2013; 7: 669-671. (VUmc) 293. de Boer KHN, van Asseldonk DP, Seinen ML, van Bodegraven AA. Oxidation-Mediated DNA Crosslinking Contributes to Toxicity of 6-Thioguanine in Human Cells - Letter. Cancer Res 2013; 73: 1445. (VUmc) 294. de Boer KHN, van Bodegraven AA. Allopurinol in Subjects with Colorectal Adenoma-Letter. Cancer Prevention Research 2013; 6: 368. (VUmc) 295. de Boer KHN, van Grieken NCT, van Weyenberg SJB. Duodenal lymphoid nodularity in common variable immunodeficiency. Dig Liver Dis 2013; 45: e5. (VUmc) 296. De Boer M , Boeker EB, Ramrattan MA, Kiewiet JJS, Dijkgraaf MGW, Boermeester MA, Lie-A-Huen L. Adverse drug events in surgical patients: an observational multicentre study. International Journal of Clinical Pharmacy 35(5), 2013, p.744-752. (AMC) 297. De Boer M. Kiewiet JJS, Boeker EB, Ramrattan MA, Dijkgraaf MGW, Lie-A-Huen L, Boermeester MA. A targeted method for standardized assessment of adverse drug events in surgical patients. Journal of Evasluation in Clinical Practice 19(6), 2013, p.1073-1082. (AMC) 298. De Boer P, Adam JA, Buist MR, van de Vijver MJ, Rasch CR, Stoker J, Bipat S, Stalpers LJA. Role of MRI in detecting involvement of the uterine internal os in uterine cervical cancer: systematic review of diagnostic test accuracy. European Journal of Radiology 82(9), 2013, p.e422-e428. (AMC) 299. de Boer YS, van Gerven NMF, de Boer KHN, Mulder CJJ, Bouma G, van Nieuwkerk CMJ. Allopurinol safely and effectively optimises thiopurine metabolites in patients with autoimmune hepatitis. Aliment Pharm Therap 2013; 37: 640-646. (VUmc) 300. de Boer YS, van Gerven NMF, de Boer KHN, Mulder CJJ, Bouma G, van Nieuwkerk CMJ. Letter: allopurinol co-therapy is safe and effective in autoimmune hepatitis authors' reply. Aliment Pharm Therap 2013; 37: 920. (VUmc) 301. de Bree R, Hoekstra OS. The potential of FDG-PET in the detection of occult lymph node metastasis: importance of patient selection and reference standard. Eur Arch Oto-Rhino-L 2013; 270: 2173-2174. (NKI/VUmc) 302. de Bree R. Functional imaging to predict treatment response after (chemo) radiotherapy of head and neck squamous cell carcinoma. Quantitative Imaging in Medicine and Surgery 2013; 3: 231-234. (VUmc) 303. de Bree R. How to analyze the diagnostic value of sentinel node biopsy in head and neck cancer. Eur Arch Oto-Rhino-L 2013; 270: 789-791. (VUmc) 304. de Bruijn MJ, Rinkel RN, Cnossen IC, Witte BI, Langendijk JA, Leemans CR, Verdonck-de Leeuw IM. Associations between voice quality and swallowing function in patients treated for oral or oropharyngeal cancer. Support Care Cancer 2013; 21: 2025-2032. (VUmc) 305. De Bruijn RE, Heideman DAM, Kenter GG, van Beurden M, van Tinteren H, Horenblas S. Patients with penile cancer and the risk of (pre)malignant cervical lesions in female partners: a retrospective cohort analysis. BJU International 112(7), 2013, p.905-908. (AMC/NKI/VUmc) 306. De Bruin AM, Demirel Ö, Hooibrink B, Brandts CH, Nolte MA. Interferon-gamma impairs proliferation of hematopoietic stem cells in mice. Blood 121(18), 2013, p.3578-3585. (AMC) 307. De Bruin NMWJ, van Drimmelen M, Kops M, van Elk J, Wetering MMVD, Schwienbacher I. Effects of risperidone, clozapine and the 5-HT6 antagonist GSK-742457 on PCP-induced deficits in reversal learning in the two-lever operant task in male Sprague Dawley rats. Behav Brain Res 2013; 244:15-28 (NKI) 308. de Crom SCM, Obihara CC, de Moor RA, Veldkamp EJM, van Furth AM, Rossen JWA. Prospective comparison of the detection rates of human enterovirus and parechovirus RT-qPCR and viral culture in different pediatric specimens. J Clin Virol 2013; 58: 449-454. (VUmc) 309. de Cuba EMV, Kwakman R, Knol DL, Bonjer HJ, Meijer GA, te Velde EA. Cytoreductive surgery and HIPEC for peritoneal metastases combined with curative treatment of colorectal liver metastases Systematic review of all literature and meta-analysis of observational studies. Cancer Treat Rev 2013; 39: 321-327. (VUmc) 310. De Filippo K, Dudeck A, Hasenberg M, Nye E, van Rooijen N, Hartmann K, Gunzer M, Roers A, Hogg N. Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation. Blood 2013; 121: 4930-4937. (VUmc)
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311. de Geus ED, Tefsen B, van Haarlem DA, van Eden W, van Die I, Vervelde L. Glycans from avian influenza virus are recognized by chicken dendritic cells and are targets for the humoral immune response in chicken. Mol Immunol 2013; 56: 452-462. (VUmc) 312. de Goede B, Klitsie PJ, Hagen SM, van Kempen BJH, Spronk S, Metselaar HJ, Lange JF, Kazemier G. Meta-analysis of laparoscopic versus open cholecystectomy for patients with liver cirrhosis and symptomatic cholecystolithiasis. Brit J Surg 2013; 100: 209-216. (VUmc) 313. de Goede B, Klitsie PJ, van Kempen BJH, Timmermans L, Jeekel J, Kazemier G, Lange JF. Meta-analysis of glue versus sutured mesh fixation for Lichtenstein inguinal hernia repair. Brit J Surg 2013; 100: 735- 742. (VUmc) 314. de Goede B, van Kempen BJH, Polak WG, de Knegt RJ, Schouten JNL, Lange JF, Tilanus HW, Metselaar HJ, Kazemier G. Umbilical hernia management during liver transplantation. Hernia 2013; 17: 515-519. (VUmc) 315. De Graaf CA, van Steensel B. Chromatin organization: form to function. Curr Opin Genet Dev 2013; 23:185-90 (NKI) 316. de Graaf G, Stijns P, Scheepens W, van Moorselaar RJA, Hendrikx AJM. The use of a menokath prostatic stent for obstructive voiding symptoms after brachytherapy. Current Urology 2013; 7: 19-23. (VUmc) 317. De Graaf M, Pasmans SGMA, van Drooge AM, Nievelstein RAJ, Gooskens RHJ, Raphael MF, Breugem CC. Associated anomalies and diagnostic approach in lumbosacral and perineal haemangiomas: case report and review of the literature. Journal of Plastic Reconstructive and Aesthetic Surgery 66(1), 2013, p.e26-e28. (AMC) 318. De Greef M, Ipek O, Raaijmakers AJE, Crezee J, van den Berg CAT. Specific Absorption Rate Intersubject Variability in 7T Parallel Transmit MRI of the Head. Magnetic Resonance in Medicine 69(5), 2013, p.1476-1485. (AMC) 319. de Groot EH, Post N, Boellaard R, Wagenaar NR, Willemsen AT, van Dalen JA. Optimized dose regimen for whole-body FDG-PET imaging. EJNMMI research 2013; 3: 63. (VUmc) 320. De Groot JE, Broeders MJM, Branderhorst W, den Heeten GJ, Grimbergen CA. A novel approach to mammographic breast compression: Improved standardization and reduced discomfort by controlling pressure instead of force. Medical Physics 40(8), 2013, p.081901-. (AMC) 321. de Groot M, Douw L, Sizoo EM, Bosma I, Froklage FE, Heimans JJ, Postma TJ, Klein M, Reijneveld JC. Levetiracetam improves verbal memory in high-grade glioma patients. Neuro-oncology 2013; 15: 216- 223. (VUmc) 322. De Haan MC, de Wijkerslooth TR, Stoop E, Bossuyt P, Fockens P, Thomeer M, Kuipers EJ, Essink-Bot M-L, van Leerdam ME, Dekker E, Stoker J. Informed decision-making in colorectal cancer screening using colonoscopy or CT-colonography. Patient Education and Counseling 91(3), 2013, p.318-325. (AMC) 323. De Haan MC, Thomeer M, Stoker J, Dekker E, Kuipers EJ, van Ballegooijen M. Unit costs in population-based colorectal cancer screening using CT colonography performed in university hospitals in The Netherlands. European Radiology 23(4), 2013, p.897-907. (AMC) 324. De Haan R, van Triest B, Schellens JHM, Verheij M, Elkhuizen PHM, Sonke GS. Olaparib gecombineerd met locoregionale radiotherapie voor inoperabele, gemetastaseerde of inflammatoire borstkanker. Ned Tijdschr Oncol 2013; 10:293-6 (NKI) 325. De Haas EC, Altena R, Boezen HM, Zwart N, Smit AJ, Bakker SJ, van Roon AM, Postma A, Wolffenbuttel BH, Hoekstra HJ, van Leeuwen FE, Sleijfer DT, Gietema JA. Early development of the metabolic syndrome after chemotherapy for testicular cancer. Ann Oncol 2013; 24:749-55 (NKI) 326. De Heer K, van der Schee MP, Zwinderman K, van den Berk IAH, Visser CE, van Oers R, Sterk PJ. Electronic nose technology for detection of invasive pulmonary aspergillosis in prolonged chemotherapy-induced neutropenia: a proof-of-principle study. Journal of Clinical Microbiology 51(5), 2013, p.1490-1495. (AMC) 327. de Jonge J, Pont LMEB, Idema S, Kloezeman JJ, Noske D, Dirven CMF, Lamfers MLM. Therapeutic concentrations of anti-epileptic drugs do not inhibit the activity of the oncolytic adenovirus Delta24- RGD in malignant glioma. J Gene Med 2013; 15: 134-141. (VUmc) 328. de Jonge RCJ, Sanders MS, Terwee CB, Heijmans MW, Gemke RJBJ, Koomen I, Spanjaard L, van Furth AM. Independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis. PLoS One 2013; : 8. (VUmc) 329. De Keersmaecker K, Atak ZK, Li N, Vicente C, Patchett S, Girardi T, Gianfelici V, Geerdens E, Clappier E, Porcu M, Lahortiga I, Luca R, Yan JK, Hulselmans G, Vranckx H, Vandepoel R, Sweron B, Jacobs K, Mentens N, Wlodarska I, Cauwelier B, Cloos J, Soulier J, Uyttebroeck A, Bagni C, Hassan BA, Vandenberghe P, Johnson AW, Aerts S, Cools J. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat Genet 2013; 45: 186-190. (VUmc) 330. de Kemp SR, Brink A, Stigter-van Walsum M, Damen JMA, Rustenburg F, Wu T, van Wieringen WN, Schuurhuis GJ, Braakhuis BJM, Slijper M, Brakenhoff RH. CD98 marks a subpopulation of head and neck squamous cell carcinoma cells with stem cell properties. Stem Cell Res 2013; 10: 477-488. (VUmc) 331. de Kemp SR, Dalm SU, Wijnolts FMJ, van den Brink A, Honeywell RJ, Peters GJ, Braakhuis BJM, Brakenhoff RH. DNA-Bound Platinum Is the Major Determinant of Cisplatin Sensitivity in Head and Neck Squamous Carcinoma Cells. PLoS One 2013; 8: e61555. (VUmc)
Scientific publications - 99
332. de Kemp SR, Nagel CR, Stigter-van Walsum M, van der Meulen IH, van Beusechem VW, Braakhuis BJM, Brakenhoff RH. Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer. Clin Cancer Res 2013; 19: 1994-2003. (VUmc) 333. De Kinkelder R, de Bruin DM, Verbraak FD, van Leeuwen TG, Faber DJ. Comparison of retinal nerve fiber layer thickness measurements by spectral-domain optical coherence tomography systems using a phantom eye model. Journal of Biophotonics 6(4), 2013, p.314-320. (AMC) 334. de Kivita S, Kraneveld AD, Knippels LMJ, van Kooijk Y, Garssen J, Willemsen LEM. Intestinal Epithelium- Derived Galectin-9 Is Involved in the Immunomodulating Effects of Nondigestible Oligosaccharides. J Innate Immunity 2013; 5: 625-638. (VUmc) 335. de Koste JRV, Dahele MR, Mostafavi H, Senan S, van der Weide L, Slotman BJ, Verbakel WFAR. Digital tomosynthesis (DTS) for verification of target position in early stage lung cancer patients. Med Phys 2013; : 40. (VUmc) 336. De La Rosette JJMCH, Opondo D. Reply to Chandra Shekhar Biyani, Andy Myatt, Victor Palit, Neil Burgess and Adrian D. Joyce's letter to the editor re: Jean J.M.C.H. de la Rosette, Dedan Opondo, Francisco P.J. Daels, et al., on behalf of the CROES PCNL Study Group. Categorisation of complications and validation of the clavien score for percutaneous nephrolithotomy. European Urology 63(2), 2013, p.e25-e26. (AMC) 337. de Laat JM, Pieterman CRC, Weijmans M, Hermus AR, Dekkers OM, de Herder WW, van der Horst- Schrivers A, Drent ML, Bisschop PH, Havekes B, Vriens MR, Valk GD. Low Accuracy of Tumor Markers for Diagnosing Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1 Patients. J Clin Endocr Metab 2013; 98: 4143-4151. (VUmc) 338. de Leeuw DC, van den Ancker W, Denkers F, Menezes R, Westers TM, Ossenkoppele GJ, van de Loosdrecht AA, Smit L. MicroRNA Profiling Can Classify Acute Leukemias of Ambiguous Lineage as Either Acute Myeloid Leukemia or Acute Lymphoid Leukemia. Clin Cancer Res 2013; 19: 2187-2196. (VUmc) 339. De Leeuw R, Flach K, Bentin Toaldo C, Alexi X, Canisius S, Neefjes J, Michalides R, Zwart W. PKA phosphorylation redirects ERalpha to promoters of a unique gene set to induce tamoxifen resistance. Oncogene 2013; 32:3543-51 340. De Luca G, Breedijk R, Brandt R, Zeelenberg C, de Jong B, Timmermans W, Azar L, Hoebe R, Stallinga S, Manders E. Re-scan confocal microscopy: scanning twice for better resolution. Biomed Opt Express 2013; 4:2644-56 (NKI) 341. De Luca GMR, Breedijk RMP, Brandt RAJ, Zeelenberg CHC, de Jong BE, Timmermans W, Azar Nahidi L, Hoebe RA, Stallinga S, Manders EMM. Re-scan confocal microscopy: scanning twice for better resolution. Biomedical Optics Express 4(11), 2013, p.2644-2656. (AMC/NKI) 342. de Meij TGJ, Budding AE, Grasman ME, Kneepkens CMF, Savelkoul PHM, Mearin ML. Composition and diversity of the duodenal mucosa-associated microbiome in children with untreated coeliac disease. Scand J Gastroentero 2013; 48: 530-536. (VUmc) 343. de Meij TGJ, Jharap B, Kneepkens CMF, van Bodegraven AA, de Boer KHN. Long-term follow-up of children exposed intrauterine to maternal thiopurine therapy during pregnancy in females with inflammatory bowel disease. Aliment Pharm Therap 2013; 38: 38-43. (VUmc) 344. De Ridder J, Abeel T, Michaut M, Satagopam VP, Gehlenborg N. Don't Wear Your New Shoes (Yet): Taking the Right Steps to Become a Successful Principal Investigator. PLoS Comput Biol 2013; 9:e1002834 (NKI) 345. De Ridder J, Kool J, Uren AG, Bot J, de Jong J, Rust AG, Berns A, van Lohuizen M, Adams DJ, Wessels L, Reinders M. Mutational genomics for cancer pathway discovery. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 8th IAPR International Conference on Pattern Recognition in Bioinformatics, PRIB 2013; Nice; France; 17 June 2013 through 20 June 2013; Code 98017. 2013: p. 35-46 (NKI) 346. de Roest RH, Dobbs BR, Chapman BA, Batman B, O'Brien LA, Leeper JA, Hebblethwaite CR, Gearry RB. The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study. Int J Clin Pract 2013; 67: 895-903. (VUmc) 347. De Ronde J, Rigaill G, Rottenberg S, Rodenhuis S, Wessels L. Identifying subgroup markers in heterogeneous populations. Nucleic Acids Res 2013; 41:e200 (NKI) 348. De Ronde JJ, Lips EH, Mulder L, Vincent AD, Wesseling J, Nieuwland M, Kerkhoven R, Vrancken Peeters MJ, Sonke GS, Rodenhuis S, Wessels LFA. SERPINA6, BEX1, AGTR1, SLC26A3, and LAPTM4B are markers of resistance to neoadjuvant chemotherapy in HER2-negative breast cancer. Breast Cancer Res Treat 2013; 137:213-23 (NKI) 349. De Ruiter MA, van Mourik R, Schouten-van Meeteren AYN, Grootenhuis MA, Oosterlaan J. Neurocognitive consequences of a paediatric brain tumour and its treatment: a meta-analysis. Developmental Medicine and Child Neurology 55(5), 2013, p.408-417. (AMC) 350. De Ruiter MB, Schagen SB. Functional MRI studies in non-CNS cancers. Brain Imag Behav 2013; 7:388-408 (NKI) 351. De Ruysscher D, Belderbos J, Reymen B, van Elmpt W, van Baardwijk A, Wanders R, Hoebers F, Vooijs M, Ollers M, Lambin P. State of the art radiation therapy for lung cancer 2012: a glimpse of the future. Clin Lung Cancer 2013; 14:89-95 (NKI) 352. De Sousa E Melo F, Vermeulen L, Fessler E, Medema JP. Cancer heterogeneity--a multifaceted view. EMBO Reports 14(8), 2013, p.686-695. (AMC) 353. 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100 - Scientific publications
Leersum R, Bijlsma MF, Rodermond H, van der Heijden M, van Noesel CJM, Tuynman JB, Dekker E, Markowetz F, Medema JP, Vermeulen L. Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nature Medicine 19(5), 2013, p.614-618. (AMC) 354. de Vet HCW, Mokkink LB, Terwee CB, Hoekstra OS, Knol DL. Clinicians are right not to like Cohen's kappa. BMJ 2013; : 346. (VUmc) 355. De Visscher S, Melchers L, Dijkstra P, Karakullukcu B, Tan IB, Hopper C, Roodenburg J, Witjes M. mTHPC-mediated photodynamic therapy of early stage oral squamous cell carcinoma: a comparison to surgical treatment. Ann Surg Oncol 2013; 20:3076-82 (NKI) 356. De Visscher SAHJ, Dijkstra PU, Tan IB, Roodenburg JLN, Witjes MJH. mTHPC mediated photodynamic therapy (PDT) of squamous cell carcinoma in the head and neck: a systematic review. Oral Oncol 2013; 49:192-210 (NKI) 357. De Visser M, Fluit C, Timmer-Bonte J, Ottevanger P, Verhagen C, Klaassen T, van Laarhoven HWM. Teaching adjuvant endocrine breast cancer treatment to medical students. Netherlands Journal of Medicine 71(4), 2013, p.215-219. (AMC) 358. de Vos J, Menko FH, Oosterwijk JC, van Asperen CJ, Stiggelbout AM, Tibben A. Genetic counseling does not fulfill the counselees' need for certainty in hereditary breast/ovarian cancer families: an explorative assessment. Psycho-Oncol 2013; 22: 1167-1176. (VUmc) 359. de Vos J, van Asperen CJ, Oosterwijk JC, Menko FH, Collee MJ, Garcia EG, Tibben A. The counselees' self-reported request for psychological help in genetic counseling for hereditary breast/ovarian cancer: not only psychopathology matters. Psycho-Oncol 2013; 22: 902-910. (VUmc) 360. de Vos van Steenwijk PJ, Ramwadhdoebe TH, Goedemans R, Doorduijn EM, van Ham JJ, Gorter A, van HT, Kuijjer ML, van Poelgeest MI, van der Burg SH, Jordanova ES. Tumor-infiltrating CD14-positive myeloid cells and CD8-positive T-cells prolong survival in patients with cervical carcinoma. Int J Cancer 2013; 133: 2884-2894. (VUmc) 361. De Vries DK, Kortekaas KA, Tsikas D, Wijermars LM., van Noorden CJF, Suchy M-T, Cobbaert CM, Klautz RJM, Schaapherder AFM, Lindeman JHN. Oxidative damage in clinical ischemia/reperfusion injury: a reappraisal. Antioxidants & Redox Signaling 19(6), 2013, p.535-545. (AMC) 362. de Vries MC, Bresters D, Kaspers GJL, Houtlosser M, Wit JM, Engberts DP, van Leeuwen E. What constitutes the best interest of a child? Views of parents, children, and physicians in a pediatric oncology setting. AJOB Primary Research 2013; 4 (2): 1-10. (VUmc) 363. De Vries-van Leeuwen IJ, Costa Pereira D, Flach KD, Piersma SR, Haase C, Bier D, Yalcin Z, Michalides R, Feenstra KA, Jim+¬nez CR, De Greef TFA, Brunsveld L, Ottmann C, Zwart W, De Boer AH. 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374. Deenen MJ, Dewit L, Boot H, Beijnen JH, Schellens JH, Cats A. Simultaneous integrated boost-intensity modulated radiation therapy with concomitant capecitabine and mitomycin C for locally advanced anal carcinoma: a phase 1 study. Int J Radiat Oncol Biol Phys 2013; 85:e201-e207 (NKI) 375. Deenen MJ, Rosing H, Hillebrand MJ, Schellens JH, Beijnen JH. Quantitative determination of capecitabine and its six metabolites in human plasma using liquid chromatography coupled to electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2013; 913- 914:30-40 (NKI) 376. Dees-Ribbers HM, Pos FJ, Betgen A, Bex A, Hulshof MCCM, Remeijer P, van Herk M. Fusion of planning CT and ystoscopy images for bladder tumor delineation: a feasibility study. Medical Physics 40(5), 2013, p.051713-. (AMC/NKI) 377. Deganello A, Gitti G, Struijs B, Paiar F, Gallo O. Palliative combined treatment for unresectable cutaneous basosquamous cell carcinoma of the head and neck. 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397. Denters MJ, Schreuder M, Depla ACTM, Mallant-Hent RC, van Kouwen MCA, Deutekom M, Bossuyt PM, Fockens P, Dekker E. Patients' perception of colonoscopy: patients with inflammatory bowel disease and irritable bowel syndrome experience the largest burden. European Journal of Gastroenterology & Hepatology 25(8), 2013, p.964-972. (AMC) 398. Deppong CM, Bricker TL, Rannals BD, van Rooijen N, Hsieh CS, Green JM. CTLA4Ig Inhibits Effector T Cells through Regulatory T Cells and TGF-beta. J Immunol 2013; 191: 3082-3089. (VUmc) 399. Derissen E, Hillebrand M, Rosing H, Otten H, Laille E, Schellens J, Beijnen J. Quantitative determination of azacitidine triphosphate in peripheral blood mononuclear cells using liquid chromatography coupled with high-resolution mass spectrometry. J Pharm Biomed Anal 2013; 90C:7-14 (NKI) 400. Derissen EJB, Beijnen JH, Schellens JHM. Concise drug review: Azacitidine and decitabine. Oncologist 2013; 18:619-24 (NKI) 401. 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418. Djajadiningrat R, Horenblas S. Competing-risks analysis in patients with T1 squamous cell carcinoma of the penis. BJU Int 2013; 111:E180 (NKI) 419. Dmitriev ID, Loo CE, Vogel WV, Pengel KE, Gilhuijs KG. Fully automated deformable registration of breast DCE-MRI and PET/CT. Phys Med Biol 2013; 58:1221-33 (NKI) 420. Dobbe JGG, Vroemen JC, Strackee SD, Streekstra GJ. Corrective distal radius osteotomy: including bilateral differences in 3-D planning. Medical & Biological Engeneering & Computing 51(7), 2013, p.791-797. (AMC) 421. Dobbe JGG, Vroemen JC, Strackee SD, Streekstra GJ. Patient-tailored plate for bone fixation and accurate 3D positioning in corrective osteotomy. Medical & Biological Engineering & Computing 51(1-2), 2013, p.19-27. (AMC) 422. Donker JMW, Kluijtmans JAJW, Veen EJ, Ho GH, Hendriks YJAM, van der Laan L. The Registration of Surgical Site Infections: A Comparison of Two Different Methods in Vascular Surgery. Surgical infections 2013; 14: 397-400. (VUmc) 423. Donker M, Drukker CA, Valdés Olmos RA, Rutgers EJTh, Loo CE, Sonke GS, Wesseling J, Alderliesten T, Vrancken Peeters M-JTFD. Guiding breast-conserving surgery in patients after neoadjuvant systemic therapy for breast cancer: a comparison of radioactive seed localization with the ROLL technique. Annals of Surgical Oncology 20(8), 2013, p.2569-2575. (AMC/NKI)
424. Donker M, Litière S, Werutsky G, Julien J-P, Fentiman IS, Agresti R, Rouanet P, de LaraTunon C, Bartelink H, Duez N, Rutgers EJT, Bijker N. Breast-Conserving Treatment With or Without Radiotherapy in Ductal Carcinoma In Situ: 15-Year Recurrence Rates and Outcome After a Recurrence, From the EORTC 10853 Randomized Phase III Trial. Journal of Clinical Oncology 31(32), 2013, p.4054-4059. (AMC/NKI) 425. Donker M, Straver ME, van Tienhoven G, van de Velde CJH, Mansel RE, Litière S, Werutsky G, Duez NJ, Orzalesi Lorenzo, Bouma Willem H., van der Mijle Huub, Nieuwenhuijzen Grard A. P., Veltkamp Sanne C., Helen Westenberg A, Rutgers EJT. Comparison of the sentinel node procedure between patients with multifocal and unifocal breast cancer in the EORTC 10981-22023 AMAROS Trial: identification rate and nodal outcome. European Journal of Cancer 49(9), 2013, p.2093-2100. (AMC/NKI) 426. Doornaert P, Dahele MR, Senan S, Slotman B. Non-coplanar volumetric modulated arc therapy for irradiation of paranasal sinus tumors: In response to Al-Mamgani et al., Highly-conformal intensity- modulated radiotherapy reduced toxicity without jeopardizing outcome in patients with paranasal sinus cancer treated by surgery and radiotherapy or (chemo)radiation. Oral Oncol 2012;48(9):905-11. Oral Oncol 2013; 49: E8. (VUmc) 427. Doornaert P, Dahele MR, Verbakel WFAR, Bohoudi O, Slotman BJ, Langendijk JA. The effect of induction chemotherapy on tumor volume and organ-at-risk doses in patients with locally advanced oropharyngeal cancer. Radiather Oncol 2013; 109: 269-274. (VUmc) 428. Doornebal CW, Klarenbeek S, Braumuller TM, Klijn CN, Ciampricotti M, Hau CS, Hollmann MW, Jonkers J, de Visser KE. A preclinical mouse model of invasive lobular breast cancer metastasis. Cancer Res 2013; 73:353-63 (NKI) 429. Dorado-Garcia A, Bos ME, Graveland H, van Cleef BA, Verstappen KM, Kluijtmans JAJW, Wagenaar JA, Heederik DJ. Risk factors for persistence of livestock-associated MRSA and environmental exposure in veal calf farmers and their family members: an observational longitudinal study. BMJ open 2013; 3: e003272. (VUmc) 430. Dorlo TPC, Jager NGL, Beijnen JH, Schellens JHM. [Concomitant use of proton pump inhibitors and systemic corticosteroids] Protonpompremmers bij systemisch glucocorticoidgebruik. Ned Tijdschr Geneeskd 2013; 157:A5540 (NKI) 431. Douma KFL, Vasen HFA, Aaronson NK, Bleiker EMA. Reproductive decision-making in hereditary colorectal cancer: the role of the gastroenterologist. Colorectal Cancer 2013; 2:13-6 432. Douw L, de Groot M, van Dellen E, Aronica E, Heimans JJ, Klein M, Stam CJ, Reijneveld JC, Hillebrand A. Local MEG networks: The missing link between protein expression and epilepsy in glioma patients?. Neuroimage 2013; 75: 195-203. (VUmc) 433. Droog M, Beelen K, Linn S, Zwart W. Tamoxifen resistance: From bench to bedside. Eur J Pharmacol 2013; 717:47-57 (NKI) 434. Drukker CA, Bueno-de-Mesquita JM, Retèl VP, van Harten WH, van Tinteren H, Wesseling J, Roumen RMH, Knauer M, van 't Veer LJ, Sonke GS, Rutgers EJT, van de Vijver MJ, Linn SC. A prospective evaluation of a breast cancer prognosis signature in the observational RASTER study. International Journal of Cancer 133(4), 2013, p.929-936. (AMC/NKI) 435. Du Perron LJ, Westerman M, Issa A, Smorenburg CH. Unresectable pancreatic tumour? The issue is tissue. Neth J Med 2013; 71:81-3 (NKI) 436. Dubbeling RM, Ramesh K. Infected inguinal hernia mesh presenting as pseudotumor of the bladder. Indian Journal of Urology 2013; 29: 345-347. (VUmc) 437. Dubbelman AC, Rosing H, Darwish M, D'Andrea D, Bond M, Hellriegel E, Robertson J, Beijnen JH, Schellens JHM. Pharmacokinetics and excretion of 14C-bendamustine in patients with relapsed or refractory malignancy. Drugs R D 2013; 13:17-28 (NKI)
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438. Duijkers FAM, Menezes R, Goossens-Beumer IJ, Stumpel DJPM, Admiraal P, Pieters R, Meijerink JPP, van Noesel MM. Epigenetic drug combination induces genome-wide demethylation and altered gene expression in neuro-ectodermal tumor-derived cell lines. Cell Oncol 2013; 36: 351-362. (VUmc) 439. Dukers-Muijrers NHTM, Speksnijder AGCL, Morré SA, Wolffs PFG, van der Sande MAB, Brink AATP, Van Den Broek IVF, Werner MILS, Hoebe CJPA. Detection of Anorectal and Cervicovaginal Chlamydia Trachomatis Infections following Azithromycin Treatment: Prospective Cohort Study with Multiple Time- Sequential Measures of rRNA, DNA, Quantitative Load and Symptoms. PLoS One 2013; : 8. (VUmc) 440. Durmus S, Xu N, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH. P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387. Pharmacol Res 2013; 76:9-16 (NKI) 441. 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541. Giebel S, Labopin M, Mohty M, Mufti GJ, Niederwieser D, Cornelissen JJ, Janssen JJWM, Milpied N, Vindelov L, Petersen E, Arnold R, Bacigalupo A, Blaise D, Craddock C, Nagler A, Frassoni F, Sadus- Wojciechowska M, Rocha V. The impact of center experience on results of reduced intensity: allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT. Bone Marrow Transpl 2013; 48: 238-242. (VUmc) 542. Giesen E, Mager A, Van Tinteren H, Rodenhuis S, Kerst JM. An alternative treatment regimen of advanced seminoma with carboplatin, etoposide, and bleomycin instead of cisplatin-based therapy. Urol Oncol Semin Orig Invest 2013; 31:110-4 (NKI) 543. Gilchuk P, Spencer CT, Conant SB, Hill T, Gray JJ, Niu X, Zheng M, Erickson JJ, Boyd KL, McAfee KJ, Oseroff C, Hadrup SR, Bennink JR, Hildebrand W, Edwards KM, Crowe J, Williams JV, Buus S, Sette A, Schumacher TNM, Link AJ, Joyce S. 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562. Goossen GM, Kremer LCM, van de Wetering MD. Influenza vaccination in children being treated with chemotherapy for cancer. Cochrane Database of Systemic Reviews 2013(8), 2013, p.CD006484-. (AMC) 563. Gordijn MS, Gemke RJBJ, Bierings MB, Hoogerbrugge PM, Tersteeg-Kamperman MDJ, Heijnen CJ, Rotteveel J, Kaspers GJL. Adequate endocrine and cardiovascular response to social stress in survivors of childhood acute lymphoblastic leukemia. Psychoneuroendocrino 2013; 38: 3145-3149. (VUmc) 564. Gordijn MS, van Litsenburg RRL, Gemke RJ, Huisman J, Bierings MB, Hoogerbrugge PM, Kaspers GJL. Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2013; 60: 479-485. (VUmc) 565. Gorlia T, Delattre JY, Brandes AA, Kros JM, Taphoorn MJB, Kouwenhoven MCM, Bernsen HJJA, Frenay M, Tijssen CC, Lacombe D, van den Bent MJ. 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584. Groeneveld IF, de Boer AGEM, Frings-Dresen MHW. Physical exercise and return to work: cancer survivors' experiences. Journal of Cancer Survivorship-Research and Practice 7(2), 2013, p.237-246. (AMC) 585. Grootendorst DJ, Fratila RM, Visscher M, Haken BT, van Wezel RJA, Rottenberg S, Steenbergen W, Manohar S, Ruers TJM. Intra-operative ex vivo photoacoustic nodal staging in a rat model using a clinical superparamagnetic iron oxide nanoparticle dispersion. J Biophotonics 2013; 6:493-504 (NKI) 586. Grootendorst DJ, Jose J, Fratila RM, Visscher M, Velders AH, Ten Haken B, Van Leeuwen TG, Steenbergen W, Manohar S, Ruers TJ. Evaluation of superparamagnetic iron oxide nanoparticles (Endorem(R)) as a photoacoustic contrast agent for intra-operative nodal staging. Contrast Media Mol Imaging 2013; 8:83-91 (NKI) 587. Grootendorst DJ, Jose J, Fratila RM, Visscher M, Velders AH, ten Haken B, van Leeuwen TG, Steenbergen W, Manohar S, Ruers TJM. Evaluation of superparamagnetic iron oxide nanoparticles (Endorem®) as a photoacoustic contrast agent for intra-operative nodal staging. Contrast Media & Molecular Imaging 8(1), 2013, p.83-91. (AMC) 588. Grootendorst DJ, Steenbergen W, Manohar S, Ruers TJM. Optical techniques for the intraoperative assessment of nodal status. Future Oncol 2013; 9:1741-55 (NKI) 589. Groothuizen F, Fish A, Petoukhov M, Reumer A, Manelyte L, Winterwerp H, Marinus M, Lebbink J, Svergun D, Friedhoff P, Sixma T. Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation. Nucleic Acids Res 2013; 41:8166-81 (NKI)
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603. Halaby T, al Naiemi N, Kluijtmans JAJW, van der Palen J, Vandenbroucke-Grauls CMJE. Emergence of Colistin Resistance in Enterobacteriaceae after the Introduction of Selective Digestive Tract Decontamination in an Intensive Care Unit. Antimicrob Agents CH 2013; 57: 3224-3229. (VUmc) 604. Halim VA, Alvarez-Fern+índez M, Xu YJ, Aprelia M, Van Den Toorn HWP, Heck AJR, Mohammed S, Medema RH. Comparative phosphoproteomic analysis of checkpoint recovery identifies new regulators of the DNA damage response. Sci Signal 2013; 6:rs9-(10 pp) (NKI) 605. Haloua MH, Krekel NMA, Coupe VMH, Bosmans JE, Cardozo AMFL, Meijer S, van den Tol MP. Ultrasound- guided surgery for palpable breast cancer is cost-saving: Results of a cost-benefit analysis. Breast 2013; 22: 238-243. (VUmc) 606. Haloua MH, Krekel NMA, Winters HAH, Rietveld DHF, Meijer S, Bloemers FW, van den Tol MP. A Systematic Review of Oncoplastic Breast-Conserving Surgery Current Weaknesses and Future Prospects. 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(AMC/NKI) 624. Heemskerk B, Kvistborg P, Schumacher TN. The cancer antigenome. EMBO J 2013; 32:194-203 (NKI) 625. Heideman DAM, Hesselink AT, van Kemenade FJ, Iftner T, Berkhof J, Topal F, Agard D, Meijer CJLM, Snijders PJF. The Aptima HPV Assay Fulfills the Cross-Sectional Clinical and Reproducibility Criteria of International Guidelines for Human Papillomavirus Test Requirements for Cervical Screening. J Clin Microbiol 2013; 51: 3653-3657. (VUmc) 626. Heideman MR, Wilting RH, Yanover E, Velds A, de Jong J, Kerkhoven RM, Jacobs H, Wessels LF, Dannenberg JH. Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function. Blood 2013; 121:2038-50 (NKI) 627. Heijmans J, Büller NVJA, Hoff E, Dihal AA, van der Poll T, van Zoelen MAD, Bierhaus A, Biemond I, Hardwick JCH, Hommes DW, Muncan V, van den Brink GR. Rage signalling promotes intestinal tumourigenesis. Oncogene 32(9), 2013, p.1202-1206. (AMC) 628. 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AIDS Research and Human Retroviruses 2013; 29: 1300-1305. (VUmc) 641. Hermsen IGC, Haak HR, de Krijger RR, Kerkhofs TMA, Feelders RA, de Herder WW, Wilmink H, Smit JWA, Gelderblom H, de Miranda NFCC, van Eijk R, van Wezel T, Morreau H. Mutational analyses of epidermal growth factor receptor and downstream pathways in adrenocortical carcinoma. European Journal of Endocrinology 169(1), 2013, p.51-58. (AMC) 642. Hernandez D, Mee-Marquet N, Kluijtmans JAJW, Donnio PY, Quentin R, Corvaglia AR, Francois P. Whole- Genome Sequences of Staphylococcus aureus ST398 Strains of Animal Origin. Genome Announcements 2013; 1: e00689-13. (VUmc)
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643. Heskamp S, Boerman OC, Molkenboer-Kuenen JDM, Oyen WJG, van der Graaf WTA, van Laarhoven HWM. Bevacizumab reduces tumor targeting of antiepidermal growth factor and anti-insulin-like growth factor 1 receptor antibodies. International Journal of Cancer 133(2), 2013, p.307-314. (AMC) 644. Heskamp S, van Laarhoven HWM., Oyen WJG., van der Graaf WTA, Boerman OC. Tumor-receptor imaging in breast cancer: a tool for patient selection and response monitoring. Current Molecular Medicine 13(10), 2013, p.1506-1522. (AMC) 645. Hesse C, Ginter W, Forg T, Mayer CT, Baru AM, rnold-Schrauf C, Unger WWJ, Kalay H, van Kooijk Y, Berod L, Sparwasser T. In vivo targeting of human DC-SIGN drastically enhances CD8(+) T-cell-mediated protective immunity. Eur J Immunol 2013; 43: 2543-2553. (VUmc) 646. Hesseling P, Israëls T, Harif M, Chantada G, Molyneux E. Practical recommendations for the management of children with Endemic Burkitt Lymphoma (BL) in a resource limited setting. Pediatr Blood Cancer 2013; 60: 357-362. (VUmc) 647. Hesselink AT, Meijer CJLM, Poljak M, Berkhof J, van Kemenade FJ, van der Salm ML, Bogaarts M, Snijders PJF, Heideman DAM. Clinical Validation of the Abbott RealTime High Risk HPV Assay According to the Guidelines for Human Papillomavirus DNA Test Requirements for Cervical Screening. J Clin Microbiol 2013; 51: 2409-2410. (VUmc) 648. Heukelom J, Hamming O, Bartelink H, Hoebers F, Giralt J, Herlestam T, Verheij M, van den Brekel M, Vogel W, Slevin N, Deutsch E, Sonke J, Lambin P, Rasch C. Adaptive and innovative Radiation Treatment FOR improving Cancer treatment outcomE (ARTFORCE); a randomized controlled phase II trial for individualized treatment of head and neck cancer. BMC Cancer 2013; 13:84 (NKI) 649. Heukelom J, Hamming O, Bartelink H, Hoebers F, Giralt J, Herlestam T, Verheij M, van den Brekel M, Vogel W, Slevin N, Deutsch E, Sonke J-J, Lambin P, Rasch. 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Heuveling DA, van Schie A, Vugts DJ, Hendrikse NH, Yaqub MM, Hoekstra OS, Karagozoglu KH, Leemans CR, van Dongen GAMS, de Bree R. Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with Zr- 89-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients. J Nucl Med 2013; 54: 585-589. (VUmc) 654. Heuvers ME, Muskens F, Bezemer K, Lambers M, Dingemans AMC, Groen HJM, Smit EF, Hoogsteden HC, Hegmans JPJJ, Aerts JGJV. Arginase-1 mRNA expression correlates with myeloid-derived suppressor cell levels in peripheral blood of NSCLC patients. Lung Cancer 2013; 81: 468-474. (VUmc) 655. Hew MN., Zondervan PJ., Guven S, de la Rosette J, Laguna MP. Prognostic models and factors for patients with renal-cell carcinoma: a survey on their use among urologists. Journal of Endourology 27(6), 2013, p.790-799. (AMC) 656. Hiddingh L, Tannous BA, Teng J, Tops B, Jeuken JWM, Hulleman E, Boots-Sprenger SHE, Vandertop WP, Noske DP, Kaspers GJL, Wesseling P, Wurdinger T. 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osteoarthritis: An Expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheu 2013; 43: 303-313. (VUmc) 663. Hill AF, Pegtel DM, Lambertz U, Leonardi T, O'Driscoll L, Pluchino S, Ter-Ovanesyan D, Nolte-'T Hoen EN. ISEV position paper: extracellular vesicle RNA analysis and bioinformatics. J Extracell Vesicles 2013; : 2. (VUmc) 664. Hillen MA, Butow PN, Tattersall MHN, Hruby G, Boyle FM, Vardy J, Kallimanis-King BL, de Haes HCJM, Smets EMA. Validation of the English version of the Trust in Oncologist Scale (TiOS). Patient Education and Couseling 91(1), 2013, p.25-28. (AMC) 665. Hillen MA, van Vliet LM, de Haes HCJM, Smets EMA. Developing and administering scripted video vignettes for experimental research of patient-provider communication. Patient Education and Counceling 91(3), 2013, p.295-309. (AMC) 666. 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Staging laparoscopy in patients with hepatocellular carcinoma: is it useful? Surgical Endoscopy and other Interventional Techniques 27(3), 2013, p.826-831. (AMC) 675. Hoekstra LT, de Graaf W, Nibourg GAA, Heger M, Bennink RJ, Stieger B, van Gulik TM. Physiological and biochemical basis of clinical liver function tests: a review. Annals of Surgery 257(1), 2013, p.27-36. (AMC) 676. Hoekstra LT, Ruys AT, Milstein DMJ, van Samkar G, van Berge Henegouwen MI, Heger M, Verheij J, van Gulik TM. Effects of prolonged pneumoperitoneum on hepatic perfusion during laparoscopy. Annals of Surgery 257(2), 2013, p.302-307. (AMC) 677. Hoekstra LT, van Lienden KP, Verheij J, van der Loos CM, Heger M, van Gulik TM. Enhanced tumor growth after portal vein embolization in a rabbit tumor model. Journal of Surgical Research 180(1), 2013, p.89-96. (AMC) 678. Hoentjen F, Seinen ML, Hanauer SB, de Boer KHN, Rubin DT, Bouma G, Harrell LE, van Bodegraven AA. Safety and Effectiveness of Long-term Allopurinol-Thiopurine Maintenance Treatment in Inflammatory Bowel Disease. Inflamm Bowel Dis 2013; 19: 363-369. (VUmc) 679. Hofstee HMA, de Waal TT, Zweegman S, Voskuyl AE, Smulders YM, Schoordijk MCE, Janssen JJWM, Serne EH. Nailfold capillary abnormalities in sclerodermatous chronic GVHD. Bone Marrow Transpl 2013; 48: 1574-1577. (VUmc) 680. Hofstra LM, Nijhuis M, Pingen M, Mudrikova T, Riezebos-Brilman A, Smit AM, Van Ham PM, Bierman WFW, Wensing AMJ. Evolution and viral characteristics of a long-term circulating resistant HIV-1 strain in a cluster of treatment-naive patients. J Antimicrob Chemoth 2013; 68: 1246-1250. (VUmc) 681. Hogenbirk MA, Heideman MR, Velds A, van den Berk PCM, Kerkhoven RM, van Steensel B, Jacobs H. Differential Programming of B Cells in AID Deficient Mice. PLoS One 2013; 8:e69815 (NKI) 682. Holt A, Van Gestel D, Arends MP, Korevaar EW, Schuring D, Kunze-Busch MC, Louwe RJ, Vliet- Vroegindeweij C. Multi-institutional comparison of volumetric modulated arc therapy vs. intensity- modulated radiation therapy for head-and-neck cancer: a planning study. Radiat Oncol 2013; 8:26 (NKI) 683. Holz JA, Boerwinkel DF, Meijer SL, Visser M, van Leeuwen TG, Aalders MCG, Bergman JJGHM. Optimized
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endoscopic autofluorescence spectroscopy for the identification of premalignant lesions in Barrett's oesophagus. European Journal of Gastroenterology & Hepatology 25(12), 2013, p.1442-1449. (AMC) 684. Holzner B, Efficace F, Basso U, Johnson CD, Aaronson NK, Arraras JI, Smith AB, Chow E, Oberguggenberger AS, Bottomley A, Steiner H, Incrocci L, Giesinger JM. Cross-cultural development of an EORTC questionnaire to assess health-related quality of life in patients with testicular cancer: the EORTC QLQ-TC26. Qual Life Res 2013; 22:369-78 (NKI) 685. Hombrink P, Raz Y, Kester MG, de BR, Weissbrich B, von dem Borne PA, Busch DH, Schumacher TN, Falkenburg JH, Heemskerk MH. Mixed functional characteristics correlating with TCR-ligand koff -rate of MHC-tetramer reactive T cells within the naive T-cell repertoire. Eur J Immunol 2013; 43:3038-50 (NKI) 686. Hoogeboom R, van Kessel KPM, Hochstenbach F, Wormhoudt TA, Reinten RJA, Wagner K, Kater AP, Guikema JEJ, Bende RJ, van Noesel CJM. A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi. Journal of Experimental Medicine 210(1), 2013, p.59-70. (AMC) 687. Hoogeboom R, Wormhoudt TA, Schipperus MR, Langerak AW, Dunn-Walters DK, Guikema JEJ, Bende RJ, van Noesel CJM. A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient. Leukemia 27(3), 2013, p.738-740. (AMC) 688. Hoogenboom FJ, Bosker RJI, Groen H, Meijerink WJHJ, Lamme B, Pierie JPEN. Laparoscopic and open subtotal colectomies have similar short-term results. Dig Surg 2013; 30: 4-6. (VUmc) 689. Hoogendam JP, Zaal A, Rutten EGGM, Heijnen CJ, Kenter GG, Veldhuis WB, Verheijen RH, Zweemer RP. Detection of cervical cancer recurrence during follow-up: A multivariable comparison of 9 frequently investigated serum biomarkers. Gynecol Oncol 2013; 131: 655-660. (VUmc) 690. Hopman S, Merks J, Eussen H, Douben H, Snijder S, Hennekam R, de Klein A, Caron H.Structural genome variations in individuals with childhood cancer and tumour predisposition syndromes. European Journal of Cancer 49(9), 2013, p.2170-2178. (AMC)
691. Hopman SMJ, Merks JHM, de Borgie CAJM, Aalfs CM, Biesecker LG, Cole T, Eng C, Legius E, Maher ER, van Noesel MM, Verloes A, Viskochil DH, Wagner A, Weksberg R, Caron HN, Hennekam RCM. The development of a clinical screening instrument for tumour predisposition syndromes in childhood cancer patients. European Journal of Cancer 49(15), 2013, p.3247-3254. (AMC) 692. Horenblas S, Haas G. Is penile preservation of distal corporal invasive penile cancer sufficient treatment? J Urol 2013; 190:840-2 (NKI) 693. Horeweg N, van der Aalst CM, Thunnissen E, Nackaerts K, Weenink C, Groen HJM, Lammers JW, Aerts JGJV, Scholten ET, van Rosmalen J, Mali W, Oudkerk M, Koning HJ. Characteristics of Lung Cancers Detected by Computer Tomography Screening in the Randomized NELSON Trial. Am J Resp Crit Care 2013; 187: 848-854. (VUmc) 694. Horeweg N, van der Aalst CM, Vliegenthart R, Zhao Y, Xie X, Scholten ETH, Mali W, Thunnissen E, Weenink C, Groen HJM, Lammers JW, Nackaerts K, van Rosmalen J, Oudkerk M, Koning HJ. Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial. Eur Respir J 2013; 42: 1659-1667. (VUmc) 695. Horlings HM, van de Vijver MJ, Wesseling J. High throughput-technologie. Kanker Breed 2013; 5:14-7 (NKI) 696. Horlings HM, Weigelt B, Anderson EM, Lambros MB, Mackay A, Natrajan R, Ng CKY, Geyer FC, van de Vijver MJ, Reis-Filho JS. Genomic profiling of histological special types of breast cancer. Breast Cancer Research and Treatment 142(2), 2013, p.257-269. (AMC) 697. Horn KE, Glasgow SD, Gobert D, Bull SJ, Luk T, Girgis J, Tremblay ME, McEachern D, Bouchard JF, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, Chapman CA, Ruthazer ES, Kennedy TE. DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Rep 2013; 3:173-85 (NKI) 698. Horwich A, Hugosson J, de Reijke T, Wiegel T, Fizazi K, Kataja V. Prostate cancer: ESMO Consensus Conference Guidelines 2012. Annals of Oncology 24(5), 2013, p.1141-1162. (AMC) 699. Horwich A, Parker C, de Reijke T, Kataja V. Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 24(Suppl. 6), 2013, p.106-114. (AMC) 700. Hou Q, Tan H, Lim K, Lim T, Khoo A, Tan I, Yeoh K, Chung M. Identification and functional validation of caldesmon as a potential gastric cancer metastasis-associated protein. J Proteome Res 2013; 12:980-90 (NKI) 701. Houben AJS, Van Wijk XMR, Van Meeteren LA, van Zeijl L, Van de Westerlo EM, Hausmann J, Fish A, Perrakis A, Van Kuppevelt TH, Moolenaar WH. The polybasic insertion in autotaxin alpha confers specific binding to heparin and cell surface heparan sulfate proteoglycans. J Biol Chem 2013; 288:510-9 (NKI) 702. Houweling A, Wolf A, Vogel W, Hamming-Vrieze O, Vliet-Vroegindeweij C, van de Kamer J, van der Heide U. FDG-PET and diffusion-weighted MRI in head-and-neck cancer patients: implications for dose painting. Radiother Oncol 2013; 106:250-4 (NKI) 703. Hoving S, Seemann I, Visser N, te Poele J, Stewart F. Thalidomide is not able to inhibit radiation- induced heart disease. Int J Radiat Biol 2013; 89:685-91 (NKI) 704. Huang J, Liu S, Bellani MA, Thazhathveetil AK, Ling C, de Winter JP, Wang YS, Wang WD, Seidman MM. The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks. Molecular Cell 2013; 52: 434-446. (VUmc)
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768. Kamieniak MM, Munoz-Repeto I, Rico D, Osorio A, Urioste M, Garcia-Donas J, Hernando S, Robles-Diaz L, Ramon YC, Cazorla A, Saez R, Garcia-Bueno JM, Domingo S, Borrego S, Palacios J, van de Wiel M, Ylstra B, Benitez J, Garcia MJ. DNA copy number profiling reveals extensive genomic loss in hereditary BRCA1 and BRCA2 ovarian carcinomas. Brit J Cancer 2013; 108: 1732-1742. (VUmc) 769. Kamphuis G, de Reijke T, de la Rosette J. Improvements in endoscopic urothelial tumor visualization. Journal of endourology 27(11), 2013, p.1314-1315. (AMC) 770. Kaplon J, Zheng L, Meissl K, Chaneton B, Selivanov V, Mackay G, van der Burg S, Verdegaal E, Cascante M, Shlomi T, Gottlieb E, Peeper D. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature 2013; 498:109-12 (NKI) 771. Karakullukcu B, Stoker SD, Wildeman AP, Copper MP, Wildeman MA, Tan IB. A matched cohort comparison of mTHPC-mediated photodynamic therapy and trans-oral surgery of early stage oral cavity squamous cell cancer. Eur Arch Otorhinolaryngol 2013; 270:1093-7 (NKI) 772. Karakullukcu B, van Veen R, Aans J, Hamming-Vrieze O, Navran A, Teertstra HJ, van den Boom F, Niatsetski Y, Sterenborg HJCM, Tan IB. MR and CT based treatment planning for mTHPC mediated interstitial photodynamic therapy of head and neck cancer: description of the method. Lasers Surg Med 2013; 45:517-23 (NKI) 773. Karrich JJ, Jachimowski LCM, Nagasawa M, Kamp A, Balzarolo M, Wolkers MC, Uittenbogaart CH, van Ham SM, Blom B. IL-21-stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation. Blood 121(16), 2013, p.3103-3111. (AMC) 774. Kaspers GJL, Zimmermann M, Reinhardt D, Gibson BES, Tamminga RYJ, Aleinikova O, Armendariz H, Dworzak M, Ha SY, Hasle H, Hovi L, Maschan A, Bertrand Y, Leverger GG, Razzouk BI, Rizzari C, Smisek P, Smith O, Stark B, Creutzig U. Improved Outcome in Pediatric Relapsed Acute Myeloid Leukemia: Results of a Randomized Trial on Liposomal Daunorubicin by the International BFM Study Group. J Clin Oncol 2013; 31: 599-607. (VUmc) 775. Kater AP. The half-life of guidelines for Waldenstrom's macroglobulinaemia; short stickiness for a sticky disease?. Netherlands Journal of Medicine 71(2), 2013, p.52-53. (AMC) 776. Kato J, Okamoto T, Motoyama H, Uchiyama R, Kirchhofer D, van Rooijen N, Enomoto H, Nishiguchi S, Kawada N, Fujimoto J, Tsutsui H. Interferon-gamma-mediated tissue factor expression contributes to T- cell-mediated hepatitis through induction of hypercoagulation in mice. Hepatology 2013; 57: 362-372. (VUmc)
777. Kawasaki N, Vela JL, Nycholat CM, Rademacher C, Khurana A, van Rooijen N, Crocker PR, Kronenberg M, Paulson JC. Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. P Natl Acad SCI USA 2013; 110: 7826- 7831. (VUmc) 778. Kazemier G, van Veen-Berkx E. Comment on "Identification and Use of Operating Room Efficiency Indicators: the Problem of Definition". Canadian Journal of Surgery 2013; 56: E103-E104. (VUmc) 779. Kelderman S, van der Kooij M, van den Eertwegh A, Soetekouw P, Jansen R, van den Brom R, Hospers G, Haanen J, Kapiteijn E, Blank C. Ipilimumab in pretreated metastastic uveal melanoma patients. Results of the Dutch Working group on Immunotherapy of Oncology (WIN-O). Acta Oncol 2013; 52:1786-8 (NKI) 780. Kelderman S, van der Kooij MK, van den Eertwegh AJM, Soetekouw PMMB, Jansen RLH, van den Brom RRH, Hospers GAP, Haanen JBAG, Kapiteijn E, Blank CU. Ipilimumab in pretreated metastastic uveal melanoma patients. Results of the Dutch Working group on Immunotherapy of Oncology (WIN-O). ACTA Oncol 2013; 52: 1786-1789. (VUmc) 781. Kerkhof M, Dielemans JCM, van Breemen MS, Zwinkels H, Walchenbach R, Taphoorn MJ, Vecht CJ. Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme. Neuro- oncology 2013; 15: 961-967. (VUmc) 782. Kerkhoff N, Bontkes HJ, Westers TM, de Gruijl TD, Kordasti S, van de Loosdrecht AA. Dendritic cells in myelodysplastic syndromes: from pathogenesis to immunotherapy. Immunotherapy 2013; 5: 621-637. (VUmc) 783. Kerkhofs TMA, Verhoeven RHA, Bonjer HJ, Nieveen van Dijkum EJ, Vriens MR, de Vries J, van Eijck CH, Bonsing BA, van de Poll-Franse LV, Haak HR. Surgery for adrenocortical carcinoma in The Netherlands: analysis of the national cancer registry data. European Journal of Endocrinology 169(1), 2013, p.83-89. (AMC) 784. Kerkhofs TMA, Verhoeven RHA, Bonjer HJ, van Dijkum EJN, Vriens MR, de Vries J, van Eijck CH, Bonsing BA, van de Poll-Franse L, Haak HR. Surgery for adrenocortical carcinoma in The Netherlands: analysis of the national cancer registry data. Eur J Endocrinol 2013; 169: 83-89. (VUmc) 785. Kerklaan BM, Di+¬ras V, Le Tourneau C, Mergui-Roelvink M, Huitema ADR, Rosing H, Beijnen JH, Marreaud S, Govaerts AS, Piccart-Gebhart MJ, Schellens JHM, Awada A. Phase i study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023. Cancer Chemother Pharmacol 2013; 71:53-62 (NKI) 786. Kestens C, van Oijen MGH, Mulder CLJ, van Bodegraven AA, Dijkstra G, de Jong D, Ponsioen C, van Tuyl BAC, Siersema PD, Fidder HH, Oldenburg B. Adalimumab and Infliximab Are Equally Effective for Crohn's Disease in Patients Not Previously Treated With Anti-Tumor Necrosis Factor-alpha Agents. Clin Gastroenterol Hepatol 2013; 11: 826-831. (VUmc)
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787. Ketema M, Kreft M, Secades P, Janssen H, Sonnenberg A. Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis. Mol Biol Cell 2013; 24:2454-66 (NKI) 788. Keyzer-Dekker CMG, de VJ, Mertens MC, Roukema JA, van der Steeg AFW. Cancer or no cancer: the influence of trait anxiety and diagnosis on quality of life with breast cancer and benign disease: a prospective, longitudinal study. World J Surg 2013; 37: 2140-2147. (VUmc) 789. Kilsdonk E, Peute LW, Riezebos RJ, Kremer LC, Jaspers MWM. From an expert-driven paper guideline to a user-centred decision support system: a usability comparison study. Artifical Intelligence in Medicine 59(1), 2013, p.5-13. (AMC) 790. Kimura Y, Takada T, Strasberg SM, Pitt Henry A, Gouma J, Garden OJ, Büchler MW, Windsor JA, Mayumi T, Yoshida M, Miura F, Higuchi R, Gabata T, Hata J, Gomi H, Dervenis C, Lau W-Y, Belli G, Kim M-H, Hilvano SC, Yamashita Y. TG13 current terminology, etiology, and epidemiology of acute cholangitis and cholecystitis. Journal of Hepato-Biliary-Pancreatic Sciences 20(1), 2013, p.8-23. (AMC) 791. Kind J, Pagie L, Ortabozkoyun H, Boyle S, de Vries S, Janssen H, Amendola M, Nolen L, Bickmore W, van Steensel B. Single-cell dynamics of genome-nuclear lamina interactions. Cell 2013; 153:178-92 (NKI) 792. Kinds MB, Marijnissen ACA, Bijlsma JWJ, Boers M, Lafeber FPJG, Welsing PMJ. Quantitative Radiographic Features of Early Knee Osteoarthritis: Development Over 5 Years and Relationship with Symptoms in the CHECK Cohort. J Rheumatol 2013; 40: 58-65. (VUmc) 793. 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Kleinerman RA, Smith SA, Holowaty E, Hall P, Pukkala E, Vaalavirta L, Stovall M, Weathers R, Gilbert E, Aleman BMP, Kaijser M, Andersson M, Storm H, Joensuu H, Lynch CF, Dores GM, Travis LB, Morton LM, Curtis RE. Radiation dose and subsequent risk for stomach cancer in long-term survivors of cervical cancer. Int J Radiat Oncol Biol Phys 2013; 86:922-9 (NKI) 801. Klijn C, Koudijs MJ, Kool J, ten Hoeve J, Boer M, de Moes J, Akhtar W, van Miltenburg M, Vendel- Zwaagstra A, Reinders MJT, Adams DJ, van Lohuizen M, Hilkens J, Wessels LFA, Jonkers J. Analysis of Tumor Heterogeneity and Cancer Gene Networks Using Deep Sequencing of MMTV-Induced Mouse Mammary Tumors. PLoS One 2013; 8:e62113 (NKI) 802. Klodzinska S, Vos JMI, Kersten MJ, Wijermans P, Minnema MC. A survey on diagnostic methods and treatment strategies used in patients with Waldenström's macroglobulinaemia in The Netherlands. Netherlands Journal of Medicine 71(2), 2013, p.90-96. (AMC) 803. Kloke BP, Kutscher S, Rae R, Kvistborg P, Britten CM, Hadrup SR. Toward next-generation cancer immunotherapy: 10th Annual Meeting of the Association for Cancer Immunotherapy (CIMT), Mainz, Germany, May 23-25, 2012. Cancer Immunol Immunother 2013; 62:975-81 (NKI) 804. Klopotowska JE, Wierenga PC, Smorenburg SM, Stuijt CCM, Arisz L, Kuks PFM, Dijkgraaf MGW, Lie-A-Huen L, de Rooij SE. Recognition of adverse drug events in older hospitalized medical patients. European Journa of Clinical Pharmacology 69(1), 2013, p.75-85. 805. Klopotowska JE, Wierenga PC, Stuijt CCM, Arisz L, Dijkgraaf MGW, Kuks PFM, Asscheman H, de Rooij SE, Lie-A-Huen L, Smorenburg SM.: Adverse drug events in older hospitalized patients: results and reliability of a comprehensive and structured identification strategy. PLOS One 8(8), 2013, p.e71045-. (AMC) 806. 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122 - Scientific publications
808. Knijn N, de Ridder JAM, Punt CJA, de Wilt JHW, Nagtegaal ID. Histopathological evaluation of resected colorectal cancer liver metastases: what should be done? Histopathology 63(2), 2013, p.149-156. (AMC) 809. Knijnenburg SL, Kremer LC, Versluys AB, Braam KI, Mud MS, van der Pal HJ, Caron HN, Jaspers MW. Evaluation of a patient information website for childhood cancer survivors. Support Care Cancer 2013; 21: 919-926. (VUmc/AMC) 810. Knijnenburg SL, Mulder RL, Schouten-van Meeteren AYN, Bökenkamp A, Blufpand H, van Dulmen-den Broeder E, Veening MA, Kremer LCM, Jaspers MWM. Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer. Cochrane Database of Systematic Reviews 2013(10), 2013, p.CD008944-. (VUmc/AMC) 811. Knijnenburg SL, Raemaekers S, van den Berg H, van Dijk IWEM, Lieverst JA, van der Pal HJ, Jaspers MWM, Caron HN, Kremer LC, van Santen HM. Final height in survivors of childhood cancer compared with Height Standard Deviation Scores at diagnosis. Annals of Oncology 24(4), 2013, p.1119-1126. (AMC) 812. Knoop J, Dekker J, van der Leeden M, van der Esch M, Thorstensson CA, Gerritsen M, Voorneman RE, Peter WF, de Rooij M, Romviel S, Lems WF, Roorda LD, Steultjens MPM. Knee joint stabilization therapy in patients with osteoarthritis of the knee: a randomized, controlled trial. Osteoarthr Cartilage 2013; 21: 1025-1034. (VUmc) 813. Knops AM., Goossens A, Ubbink DT, Legemate DA, Stalpers LJ, Bossuyt PM. Interpreting patient decisional conflict scores: behavior and emotions in decisions about treatment. Medical Decision Making 33(1), 2013, p.78-84. (AMC) 814. Knops RR, van Dalen EC, Mulder RL, Leclercq E, Knijnenburg SL, Kaspers GJ, Pieters R, Caron HN, Kremer LC. The volume effect in paediatric oncology: a systematic review. Ann Oncol 2013; 24: 1749- 1753. (VUmc) 815. Knops RRG, van Dalen EC, Mulder RL, Leclercq E, Knijnenburg SL, Kaspers GJL, Pieters R, Caron HN, Kremer LCM. The volume effect in paediatric oncology: a systematic review. Annals of Oncology 24(7), 2013, p.1749-1753. (AMC) 816. Ko E, Brouns EREA, Korones DN, Pochal WF, Philipone EM, Zegarelli DJ, Yoon AJ. Primary Ewing sarcoma of the anterior mandible localized to the midline. Oral surgery oral medicine oral pathology oral radiology 2013; 115: E46-E50. (VUmc) 817. Kocemba KA, van Andel H, de Haan-Kramer A, Mahtouk K, Versteeg R, Kersten MJ, Spaargaren M, Pals ST. The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis. Leukemia 27(8), 2013, p.1729-1737. (AMC) 818. Koenis MMG, Brouwer RM, Van Baal GCM, Van Soelen ILC, Peper JS, Van Leeuwen M, Delemarre-Van De Waal HA, Boomsma DI, Pol HEH. Longitudinal study of hormonal and physical development in young twins. J Clin Endocrinol Metab 2013; 98:E518-E527 (NKI) 819. Koers K, Francken AB, Haanen JB, Woerdeman LA, van der Hage JA. Vemurafenib as neoadjuvant treatment for unresectable regional metastatic melanoma. J Clin Oncol 2013; 31:e251-e253 (NKI) 820. Koetser ICJ, de Vries EN, van Delden OM, Smorenburg SM, Boermeester MA, van Lienden KP. A checklist to improve patient safety in interventional radiology. Cardiovascular and Interventional Radiology 36(2), 2013, p.312-319. (AMC) 821. Koevoets R, Dirven L, Klarenbeek NB, van Krugten MV, Ronday HK, van der Heijde DMFM, Huizinga TWJ, Kerstens PSJM, Lems WF, Allaart CF. 'Insights in the relationship of joint space narrowing versus erosive joint damage and physical functioning of patients with RA'. Ann Rheum Dis 2013; 72: 870-874. (VUmc) 822. Kok HP, Gellermann J, van den Berg CAT, Stauffer PR, Hand JW, Crezee J. Thermal modelling using discrete vasculature for thermal therapy: A review. International Journal of Hyperthermia 29(4), 2013, p.336-345. (AMC) 823. Kok HP, van den Berg CAT, Bel A, Crezee J. Fast thermal simulations and temperature optimization for hyperthermia treatment planning, including realistic 3D vessel networks. Medical Physics 40(10), 2013, p.103303-. (AMC) 824. Kok PHB, van den Berg TJTP, van Dijk HW, Stehouwer M, van der Meulen IJE, Mourits MP, Verbraak FD. The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography. ACTA Ophthalmoglogica 91(5), 2013, p.418-424. (AMC) 825. Kok PHB, van Dijk HW, Stehouwer M, van den Berg TJTP, Schlingemann RO, Verbraak FD. Standardised disturbance of the optical coherence tomography signal has varying effects on the scan quality assessment when comparing four devices. Britisch Journal of Ophthalmology 97(11), 2013, p.1484-1485. (AMC) 826. Kolfschoten NE, Van Leersum NJ, Gooiker GA, Van De Mheen PJM, Eddes EH, Kievit J, Brand R, Tanis PJ, Bemelman WA, Tollenaar RAEM, Meijerink J, Wouters MWJM. Successful and safe introduction of laparoscopic colorectal cancer surgery in dutch hospitals. Ann Surg 2013; 257:916-21 (NKI) 827. Kolfschoten NE, van Leersum NJ, Gooiker GA, van de Mheen PJM, Eddes EH, Kievit J, Brand R, Tanis PJ, Bemelman WA, Tollenaar RAEM, Meijerink WJHJ, Wouters MWJM. Successful and Safe Introduction of Laparoscopic Colorectal Cancer Surgery in Dutch Hospitals. Ann Surg 2013; 257: 916-921. (VUmc) 828. Kolfschoten NE, Wouters MWJM, Gooiker GA, Eddes EH, Kievit J, Tollenaar RAEM, Marang-Van De Mheen PJ. Nonelective colon cancer resections in elderly patients: Results from the dutch surgical colorectal audit. Dig Surg 2013; 29:412-9 (NKI)
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829. Kolfschoten NE, Wouters MWJM, Gooiker GA, Van Leersum NJ, Eddes EH, Kievit J, Tollenaar RAEM, Marang-Van De Mheen PJ. Nonelective colon cancer resections in elderly patients: Results from the Dutch Surgical Colorectal Audit. Ned Tijdschr Geneeskd 2013; 157 (NKI) 830. Kolkman DGE, Rijnders MEB, Wouters MGAJ, van den Akker-van Marle, van der Ploeg CPBK, de Groot CJM, Fleuren MAH. Implementation of a cost-effective strategy to prevent neonatal early-onset group B haemolytic streptococcus disease in the Netherlands. BMC Pregnancy Childbirth 2013; : 13. (VUmc) 831. Komen L, Zwertbroek L, Burger SJ, van der Veen JPW, de Rie MA, Wolkerstorfer A. Q-switched laser depigmentation in vitiligo, most effective in active disease. British Journal of Dermatology 169(6), 2013, p.1246-1251. (AMC) 832. Konge L, Annema J, Clementsen P, Minddal V, Vilmann P, Ringsted C. Using virtual-reality simulation to assess performance in endobronchial ultrasound. Respiration 86(1), 2013, p.59-65. (AMC) 833. Konge L, Annema J, Vilmann P, Clementsen P, Ringsted C. Transesophageal ultrasonography for lung cancer staging: learning curves of pulmonologists. Journal of Thoracic Oncology 8(11), 2013, p.1402-1408. (AMC) 834. Konge L, Annema J. Assessment of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Performance. American Journal of Respiratory and Critical Care Medicine 188(2), 2013, p.254-. (AMC) 835. Konijn NPC, van Tuyl HD, Bultink IEM, Lems WF, van Bokhorst-de van der Schueren. Body Mass Index Measurements Have Limited Value for the Assessment of Body Composition in Rheumatoid Arthritis: Comment on the Article by Wolfe and Michaud. Arthritis Care Res 2013; 65: 833-834. (VUmc) 836. Koning CC, Wouterse SJ, Daams JG, Uitterhoeve LL, van den Heuvel MM, Belderbos JS. Toxicity of concurrent radiochemotherapy for locally advanced non--small-cell lung cancer: a systematic review of the literature. Clinical Lung Cancer 14(5), 2013, p.481-487. (AMC/NKI) 837. Koning JJ, Kooij G, de Vries HE, Nolte MA, Mebius RE. Mesenchymal stem cells are mobilized from the bone marrow during inflammation. Frontiers in Immunology 2013; 4: 49. (VUmc) 838. Kontny NE, Wurthwein G, Joachim B, Boddy AV, Krischke M, Fuhr U, Thompson PA, Jorger M, Schellens JH, Hempel G. Population pharmacokinetics of doxorubicin: establishment of a NONMEM model for adults and children older than 3 years. Cancer Chemother Pharmacol 2013; 71:749-63 (NKI) 839. Koo S, Wen J, Hillmer A, Cheah P, Tan P, Tan I. Current and emerging surveillance strategies to expand the window of opportunity for curative treatment after surgery in colorectal cancer. Expert Rev Anticancer Ther 2013; 13:439-50 (NKI) 840. Koole W, Schafer HS, Agami R, van Haaften G, Tijsterman M. A versatile microsatellite instability reporter system in human cells. Nucleic Acids Res 2013; 41:e158 (NKI) 841. Koolen B, Elshof L, Loo C, Wesseling J, Vrancken Peeters M, Vogel W, Rutgers E, Valdes Olmos R. Does the pretreatment tumor sampling location correspond with metabolic activity on 18F-FDG PET/CT in breast cancer patients scheduled for neoadjuvant chemotherapy? Eur J Radiol 2013; 82:2353-8 (NKI) 842. Koolen B, Valdes Olmos R, Vogel W, Vrancken Peeters M, Rodenhuis S, Rutgers E, Elkhuizen P. Pre- chemotherapy 18F-FDG PET/CT upstages nodal stage in stage II-III breast cancer patients treated with neoadjuvant chemotherapy. Breast Cancer Res Treat 2013; 141:249-54 (NKI) 843. Koolen B, Valdes Olmos R, Wesseling J, Vogel W, Vincent A, Gilhuijs K, Rodenhuis S, Rutgers E, Vrancken Peeters M. Early assessment of axillary response with (1)(8)F-FDG PET/CT during neoadjuvant chemotherapy in stage II-III breast cancer: implications for surgical management of the axilla. Ann Surg Oncol 2013; 20:2227-35 (NKI) 844. Koolen BB, Aukema TS, Gonzalez Martinez AJ, Vogel WV, Caballero Ontanaya L, Vrancken Peeters MJ, Vroonland CJ, Rutgers EJ, Benlloch Baviera JM, Valdes Olmos RA. First clinical experience with a dedicated PET for hanging breast molecular imaging. Q J Nucl Med Mol Imaging 2013; 57:92-100 (NKI) 845. Koolen BB, Pengel KE, Wesseling J, Vogel WV, Vrancken Peeters MJ, Vincent AD, Gilhuijs KG, Rodenhuis S, Rutgers EJ, Valdes Olmos RA. FDG PET/CT during neoadjuvant chemotherapy may predict response in ER-positive/HER2-negative and triple negative, but not in HER2-positive breast cancer. Breast 2013; 22:691-7 (NKI) 846. Koolen BB, van der Leij F, Vogel WV, Rutgers EJ, Vrancken Peeters MJ, Elkhuizen PH, Valdes Olmos RA. Accuracy of 18F-FDG PET/CT for primary tumor visualization and staging in T1 breast cancer. Acta Oncol 2013; 53(1):50-7:50-7 (NKI) 847. Koomoa D-LT, Geerts D, Lange I, Koster J, Pegg AE, Feith DJ, Bachmann AS. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. International Journal of Oncology 42(4), 2013, p.1219-1228. (AMC) 848. Kopacova M, Van Gossum A, Mulder CJJ, Vavrecka A, Bures J. Small Intestinal Imaging. Gastroenterology Research and Practice 2013; : 623091. (VUmc) 849. Koppelmans V, Breteler M, Boogerd W, Seynaeve C, Schagen S. Late effects of adjuvant chemotherapy for adult onset non-CNS cancer; cognitive impairment, brain structure and risk of dementia. Crit Rev Oncol Hematol 2013; 88:87-101 (NKI) 850. Koppers-Lalic D, Hogenboom MM, Middeldorp JM, Pegtel DM. Virus-modified exosomes for targeted RNA delivery; a new approach in nanomedicine. Adv Drug Deliver Rev 2013; 65: 348-356. (VUmc) 851. Kordes S, Cats A, van Laarhoven HWM. Doelgerichte therapie bij het lokaal gevorderd en gemetastaseerd maag- en oesofaguscarcinoom. Ned Tijdschr Oncol 2013; 10:152-60 (NKI) 852. Kordes S, Richel DJ, Klümpen H-J, Weterman MJ, Stevens AJWM, Wilmink JW. A phase I/II, non-randomized, feasibility/safety and efficacy study of the combination of everolimus, cetuximab and
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capecitabine in patients with advanced pancreatic cancer. Investigational New Drugs 31(1), 2013, p.85-91. (AMC) 853. Korse CM, Taal BG, van Velthuysen MLF, Visser O. Incidence and survival of neuroendocrine tumours in the Netherlands according to histological grade: Experience of two decades of cancer registry. Eur J Cancer 2013; 49:1975-83 (NKI) 854. Korsse SE, Biermann K, Offerhaus GJA, Wagner A, Dekker E, Mathus-Vliegen EMH, Kuipers EJ, van Leerdam ME, van Veelen W. Identification of molecular alterations in gastrointestinal carcinomas and dysplastic hamartomas in Peutz-Jeghers syndrome. Carcinogenesis 34(7), 2013, p.1611-1619. (AMC) 855. Korsse SE, Harinck F, van Lier MGF, Biermann K, Offerhaus GJA., Krak N, Looman CWN, van Veelen W, Kuipers EJ, Wagner A, Dekker E, Mathus-Vliegen EMH, Fockens P, van Leerdam ME, Bruno MJ. Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance. Journal of Medical Genetics 50(1), 2013, p.59-64. (AMC) 856. Kort A, Hillebrand MJX, Cirkel GA, Voest EE, Schinkel AH, Rosing H, Schellens JHM, Beijnen JH. Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2013; 925:117-23 (NKI) 857. Kortenhorst MSQ, Wissing MD, Rodriguez R, Kachhap SK, Jans JJM, van der Groep P, Verheul HMW, Gupta A, Aiyetan PO, van der Wall E, Carducci MA, van Diest PJ, Marchionni L. Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors. Epigenetics 2013; 8: 907-920. (VUmc) 858. Kozar S, Morrissey E, Nicholson AM, van der Heijden M, Zecchini HI, Kemp R, Tavaré S, Vermeulen L, Winton DJ. Continuous Clonal Labeling Reveals Small Numbers of Functional Stem Cells in Intestinal Crypts and Adenomas. Cell Stem Cell 13(5), 2013, p.626-633. (AMC) 859. Kraaij MD, Koekkoek KM, van der Kooij SW, Gelderman KA, Van Kooten C. Subsets of human type 2 macrophages show differential capacity to produce reactive oxygen species. Cell Immunol 2013; 284: 1- 8. (VUmc) 860. Kraan W, Horlings HM, van Keimpema M, Schilder-Tol EJM, Oud MECM, Scheepstra C, Kluin PM, Kersten MJ, Spaargaren M, Pals ST. High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites. Blood Cancer Journal 3, 2013, p.e139-. (AMC)
861. Kramer GM, Yaqub MM, Bahce I, Smit EF, Lubberink M, Hoekstra OS, Boellaard R. CT-perfusion versus [O- 15]H2O PET in lung tumors: Effects of CT-perfusion methodology. Med Phys 2013; 40: 052502. (VUmc) 862. Krekel NMA, Haloua MH, Cardozo AMFL, de Wit RH, Bosch AM, de Widt-Levert LM, Muller S, van der Veen H, Bergers E, de Lange-de Klerk ESM, Meijer S, van den Tol MP. Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial. Lancet Oncol 2013; 14: 48-54. (VUmc) 863. Kremer LCM, Mulder RL, Oeffinger KC, Bhatia S, Landier W, Levitt G, Constine LS, Wallace WH, Caron HN, Armenian SH, Skinner R, Hudson MM. A Worldwide Collaboration to Harmonize Guidelines for the Long-Term Follow-Up of Childhood and Young Adult Cancer Survivors: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group.P ediatric Blood & Cancer(4), 2013, p.543-549. (AMC) 864. Krieckaert CLM, Nurmohamed MT, Wolbink G, Lems WF. Changes in bone mineral density during long- term treatment with adalimumab in patients with rheumatoid arthritis: a cohort study. Rheumatology 2013; 52: 547-553. (VUmc) 865. Krijger P, Tsaalbi-Shtylik A, Wit N, van den Berk PCM, de Wind N, Jacobs H. Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway. Eur J Immunol 2013; 43:2765-70 (NKI) 866. Krijgsman O, Gonzalez P, Ponz OB, Roemer MG, Slot S, Broeks A, Braaf L, Kerkhoven RM, Bot F, van Groningen K, Beijert M, Ylstra B, De Jong D. Dissecting the gray zone between follicular lymphoma and marginal zone lymphoma using morphological and genetic features. Haematologica 2013; 98:1921-9 (NKI) 867. Krijgsman O, Gonzalez P, Ponz OB, Roemer MGM, Slot S, Broeks A, Braaf L, Kerkhoven RM, Bot F, van Groningen K, Beijert M, Ylstra B, de Jong D. Dissecting the gray zone between follicular lymphoma and marginal zone lymphoma using morphological and genetic features. Haematol-Hematol J 2013; 98: 1921- 1929. (VUmc) 868. Krijgsman O, Israeli D, van Essen HFB, Eijk PP, Berens MLM, Mellink CHM, Nieuwint AWM, Weiss MM, Steenbergen RDM, Meijer GA, Ylstra B. Detection limits of DNA copy number alterations in heterogeneous cell populations. Cell Oncol 2013; 36: 27-36. (VUmc) 869. Kroon B, de Bruijn R, Prevoo W, Horenblas S, Powles T, Bex A. Probability of downsizing primary tumors of renal cell carcinoma by targeted therapies is related to size at presentation. Urology 2013; 81:111-5 (NKI) 870. Kroon MW, Kemp EH, Wind BS, Krebbers G, Bos JD, Gawkrodger DJ, Wolkerstorfer A., van der Veen JPW, Luiten RM. Melanocyte antigen-specific antibodies cannot be used as markers for recent disease activity in patients with vitiligo. Journal of the European Academy of dermatology and venereology 27(9), 2013,
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p.1172-1175. (AMC) 871. Kruis MF, van de Kamer JB, Houweling AC, Sonke J-J, Belderbos JSA, van Herk M. PET motion compensation for radiation therapy using a CT-based mid-position motion model: methodology and clinical evaluation. International Journal of Radiation Oncology Biological Physics 87(2), 2013, p.394-400. (AMC/NKI) 872. Kruis MF, van de Kamer JB, Sonke J-J, Jansen EPM, van Herk M. Registration accuracy and image quality of time averaged mid-position CT scans for liver SBRT. Radiotherapy and Oncology 109(3), 2013, p.404-408. (AMC/NKI) 873. Kruizinga R, Scherer-Rath M, Schilderman JBAM, Sprangers MAG, van Laarhoven HWM. The life in sight application study (LISA): design of a randomized controlled trial to assess the role of an assisted structured reflection on life events and ultimate life goals to improve quality of life of cancer patients. BMC Cancer 13(1), 2013, p.360-. (AMC) 874. 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Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Mol Diagnostics 2013; 15: 415-453. (VUmc) 942. Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, Jenkins RB, Kwiatkowski DJ, Saldivar JS, Squire J, Thunnissen E, Ladanyi M. Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Thoracic Oncol 2013; 8: 823-859. (VUmc) 943. Lindenberg JJ, Oosterhoff D, Sombroek CC, Lougheed SM, Hooijberg E, Stam AGM, Santegoets SJAM, Tijssen HJ, Buter J, Pinedo HM, van den Eertwegh AJM, Scheper RJ, Koenen HJPM, van de Ven R, de Gruijl TD. IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation. PLoS One 2013; : 8. (VUmc) 944. Lindenberg JJ, van de Ven R, Lougheed SM, Zomer A, Santegoets SJAM, Griffioen AW, Hooijberg E, van den Eertwegh AJM, Thijssen VL, Scheper RJ, Oosterhoff D, de Gruijl TD. Functional characterization of a STAT3-dependent dendritic cell-derived CD14(+) cell population arising upon IL-10-driven maturation. Oncoimmunol 2013; : 2. (VUmc) 945. Lindenbergh-van der Plas M, Martens-de Kemp SR, de Maaker M, van Wieringen WN, Ylstra B, Agami R, Cerisoli F, Leemans CR, Braakhuis BJ, Brakenhoff RH. Identification of lethal microRNAs specific for head and neck cancer. Clin Cancer Res 2013; 19:5647-57 (NKI) 946. 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Infectious Diseases Society of America Clinical Practice Guideline
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for the Diagnosis and Treatment of Diabetic Foot Infections (Reprinted from Clinical Infectious Diseases, vol 54, pg 132, 2012). J Am Podiatric Med Assoc 2013; 103: 2-7. (VUmc) 952. Liu F, Yorke ED, Belderbos JS, Borst GR, Rosenzweig KE, Lebesque JV, Jackson A. Using generalized equivalent uniform dose atlases to combine and analyze prospective dosimetric and radiation pneumonitis data from 2 non-small cell lung cancer dose escalation protocols. Int J Radiat Oncol Biol Phys 2013; 85:182-9 (NKI) 953. Liu L, Lemmens VEPP, De Hingh IHJT, de Vries E, Roukema JA, van Leerdam ME, Coebergh JW, Soerjomataram I. Second primary cancers in subsites of colon and rectum in Patients with previous colorectal cancer. Dis Colon Rectum 2013; 56:158-68 (NKI) 954. Lo Galbo AM, Kuik DJ, Lips PTAM, von Blomberg BME, Bloemena E, Leemans CR, de Bree R. A prospective longitudinal study on endocrine dysfunction following treatment of laryngeal or hypopharyngeal carcinoma. Oral Oncol 2013; 49: 950-955. (VUmc) 955. Lo Galbo AM, Verdonck-de Leeuw IM, Lips P, Kuik DJ, Leemans CR, de Bree R. The effect of substitution therapy on symptoms in patients with hypothyroidism following treatment for laryngeal and hypopharyngeal carcinomas. Acta Otorhinolaryngol Ital 2013; 33: 236-242. (VUmc) 956. Lo SS, Chang EL, Ryu S, Chung H, Slotman BJ, Teh BS, Sahgal A. Best of International Stereotactic Radiosurgery Society Congress 2013: stereotactic body radiation therapy. Part II: nonspinal tumors. Future Oncology 2013; 9: 1303-1306. (VUmc) 957. Lo SS, Chang EL, Ryu S, Chung H, Slotman BJ, Teh BS, Sahgal A. Best of International Stereotactic Radiosurgery Society Congress 2013: stereotactic body radiation therapy. Part I: spinal tumors. Future Oncology 2013; 9: 1299-1302. (VUmc) 958. Lo SS, Sahgal A, Chang EL, Mayr NA, Teh BS, Huang Z, Schefter TE, Yao M, Machtay M, Slotman BJ, Timmerman RD. Serious Complications Associated with Stereotactic Ablative Radiotherapy and Strategies to Mitigate the Risk. Clin Oncol 2013; 25: 378-387. (VUmc) 959. Lo SS, Sahgal A, Slotman BJ, Mansur DB, Khouri A, Sloan AE, Machtay M, Chang EL. What is the most appropriate clinical target volume for glioblastoma?. CNS Oncology 2013; 2: 419-425. (VUmc) 960. Loayza-Puch F, Agami R. Lncing protein translation to metastasis. EMBO J 2013; 32:2657-8 (NKI) 961. Loayza-Puch F, Drost J, Rooijers K, Lopes R, Elkon R, Agami R. p53 induces transcriptional and translational programs to suppress cell proliferation and growth. Genome Biol 2013; 14:R32 (NKI) 962. Lodder WL, Gilhuijs KG, Lange CA, Pameijer FA, Balm AJ, van den Brekel MW. Semi-automated primary tumor volume measurements by dynamic contrast-enhanced MRI in patients with head and neck cancer. Head Neck 2013; 35:521-6 (NKI) 963. Lodder WL, Lange CAH, Teertstra HJ, Pameijer FA, van den Brekel MWM, Balm AJM. Value of MR and CT Imaging for Assessment of Internal Carotid Artery Encasement in Head and Neck Squamous Cell Carcinoma. Int J Surg Oncol 2013; 2013:968758 (NKI) 964. Lodder WL, Lange CAH, van Velthuysen M-LF, Hauptmann M, Balm AJM, van den Brekel MWM, Pameijer FA. Can extranodal spread in head and neck cancer be detected on MR imaging. Oral Oncology 49(6), 2013, p.626-633. (AMC/NKI) 965. Lodder WL., Gilhuijs KGA, Lange CAH, Pameijer FA, Balm AJM, van den Brekel MWM. Semi-automated primary tumor volume measurements by dynamic contrast-enhanced MRI in patients with head and neck cancer. Head and Neck Journal for the Sciences and Specialties of the Head and Neck 35(4), 2013, p.521-526. (AMC) 966. Loeve AJ, Fockens P, Breedveld P. Mechanical analysis of insertion problems and pain during colonoscopy: why highly skill-dependent colonoscopy routines are necessary in the first place... and how they may be avoided. Canadian Journal of Gastroenterology 27(5), 2013, p.293-302. 967. Lohuis P, Hakim S, Duivesteijn W, Knobbe A, Tasman A. Benefits of a short, practical questionnaire to measure subjective perception of nasal appearance after aesthetic rhinoplasty. Plast Reconstr Surg 2013; 132:913e-23e (NKI) 968. Loonen AJM, Bos MP, van Meerbergen B, Neerken S, Catsburg A, Dobbelaer I, Penterman R, Maertens G, van de Wiel P, Savelkoul PHM, van den Brule AJC. Comparison of Pathogen DNA Isolation Methods from Large Volumes of Whole Blood to Improve Molecular Diagnosis of Bloodstream Infections. PLoS One 2013; 8: e72349. (VUmc) 969. Loots C, Smits M, Omari T, Bennink R, Benninga M, van Wijk M. Effect of lateral positioning on gastroesophageal reflux (GER) and underlying mechanisms in GER disease (GERD) patients and healthy controls. Neurogasteroenterology and Motility 25(3), 2013, p.222-E162. (AMC) 970. Lopez-Ceron M, van den Broek FJC, Mathus-Vliegen EM, Boparai KS, van Eeden S, Fockens P, Dekker E. The role of high-resolution endoscopy and narrow-band imaging in the evaluation of upper GI neoplasia in familial adenomatous polyposis. Gastrointestinal Endoscopy 77(4), 2013, p.542-550. 971. Lorenz KJ, Hilgers FM, Maier H. [A novel puncture instrument: the Provox-Vega(R) puncture set. Its use in voice prosthesis insertion following laryngectomy]Neues Punktionsinstrumentarium: Provox-Vega(R)- Punktionsset. Anwendung beim Einbringen einer Stimmprothese nach Laryngektomie. HNO 2013; 61:30-7 (NKI) 972. Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyere O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter- Niesert S, Rizzoli R, Sandell LJ, van Spil WE, Reginster JY. Value of biomarkers in osteoarthritis: current status and perspectives. Ann Rheum Dis 2013; 72: 1756-1763. (VUmc)
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973. Low-Marchelli JM, Ardi VC, Vizcarra EA, van Rooijen N, Quigley JP, Yang J. Twist1 Induces CCL2 and Recruits Macrophages to Promote Angiogenesis. Cancer Res 2013; 73: 662-671. (VUmc) 974. Lubbers J, van den Brink M, de Stadt LAV, Vosslamber S, Wesseling JG, van Schaardenburg D, Rantapaa- Dahlqvist S, Verweij CL. The type I IFN signature as a biomarker of preclinical rheumatoid arthritis. Ann Rheum Dis 2013; 72: 776-780. (VUmc) 975. Lucassen WAM, Beenen LFM, Büller HR, Erkens PMG, Schaefer-Prokop CM, van den Berk IAH, van Weert HC. Concerns in using multi-detector computed tomography for diagnosing pulmonary embolism in daily practice. A cross-sectional analysis using expert opinion as reference standard. Thromobosis Research 131(2), 2013, p.145-149. (AMC) 976. Lucassen WAM, Kuijs-Augustijn M, Erkens PMG, Geersing G-J, Büller HR, van Weert HCPM. The additional value of the CRP test in patients in whom the primary care physician excluded pulmonary embolism. European Journal of General Practice 19(3), 2013, p.143-149. (AMC) 977. Luethi D, Durmus S, Schinkel AH, Schellens JHM, Beijnen JH, Sparidans RW. Liquid chromatography- tandem mass spectrometry assay for the EGFR inhibitor pelitinib in plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2013; 934:22-5 (NKI) 978. Luijten MNH, Basten SG, Claessens T, Vernooij M, Scott CL, Janssen R, Easton JA, Kamps MAF, Vreeburg M, Broers JLV, Van Geel M, Menko FH, Harbottle RP, Nookala RK, Tee AR, Land SC, Giles RH, Coull BJ, van Steensel MAM. Birt-Hogg-Dube syndrome is a novel ciliopathy. Hum Mol Genet 2013; 22: 4383-4397. (VUmc) 979. Lundberg G, Jin Y, Sehic D, Øra I, Versteeg R, Gisselsson D. Intratumour diversity of chromosome copy numbers in neuroblastoma mediated by on-going chromosome loss from a polyploid state. PLOS ONE 8(3), 2013, p.e59268-. (AMC) 980. Lundberg K, Albrekt AS, Nelissen I, Santegoets S, de Gruijl TD, Gibbs S, Lindstedt M. Transcriptional Profiling of Human Dendritic Cell Populations and Models - Unique Profiles of In Vitro Dendritic Cells and Implications on Functionality and Applicability. PLoS One 2013; 8: e52875. (VUmc) 981. Lutkenhaus LJ, Kamphuis M, van Wieringen N, Hulshof MCCM, Bel A. Reduction in cardiac volume during chemoradiotherapy for patients with esophageal cancer. Radiotherapy and Oncology 109(2), 2013, p.200-203. (AMC) 982. Lybol C, Thomas CMG, Blanken EA, Sweep FCGJ, Verheijen RH, Westermann AM, Boere IA, Reyners AKL, Massuger LFAG, van Hoesel RQGCM, Ottevanger PB. Comparing cisplatin-based combination chemotherapy with EMA/CO chemotherapy for the treatment of high risk gestational trophoblastic neoplasia. European Journal of Cancer 49(4), 2013, p.860-867. 983. Maas C, Tromp JM, van Laar J, Thijssen R, Elias JA, Malara A, Krippner-Heidenreich A, Silke J, van Oers MHJ, Eldering E. CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex. Cell Death & Disease 4, 2013, p.e782-. (AMC)
984. Maas HAAM, Lemmens VEPP, Nijhuis PHA, de Hingh IHJT, Koning CCE, Janssen-Heijnen MLG. Benefits and drawbacks of short-course preoperative radiotherapy in rectal cancer patients aged 75 years and older. EJSO : European Journal of Surgical Oncology 39(10), 2013, p.1087-1093. (AMC) 985. Maaskant-Braat AJ, Roumen RM, Voogd AC, Pijpers R, Luiten EJ, Rutgers EJ, Nieuwenhuijzen GA. Sentinel Node and Recurrent Breast Cancer (SNARB): results of a nationwide registration study. Ann Surg Oncol 2013; 20:620-6 (NKI) 986. Machado D, Shishido SM, Queiroz KCS, Oliveira DN, Faria ALC, Catharino RR, Spek CA, Ferreira CV. Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo. PLOS ONE 8(1), 2013, p.e54269-. (AMC) 987. Macintyre G, Michaut M, Abeel T. The Regional Student Group Program of the ISCB Student Council: Stories from the Road. PLoS Comput Biol 2013; 9:e1003241 (NKI) 988. Macurek L, Benada J, Mullers E, Halim VA, Krejcikova K, Burdova K, Pechackova S, Hodny Z, Lindqvist A, Medema RH, Bartek J. Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis. Cell Cycle 2013; 12:251-62 (NKI) 989. Maftouh M, Avan A, Galvani E, Peters GJ, Giovannetti E. Molecular mechanisms underlying the role of microRNAs in resistance to epidermal growth factor receptor-targeted agents and novel therapeutic strategies for treatment of non-small-cell lung cancer. Critical Reviews in Oncogenesis 2013; 18: 317- 326. (VUmc) 990. Magliozzi R, Low T, Weijts B, Cheng T, Spanjaard E, Mohammed S, van Veen A, Ovaa H, de Rooij J, Zwartkruis F, Bos J, de Bruin A, Heck A, Guardavaccaro D. Control of Epithelial Cell Migration and Invasion by the IKKbeta- and CK1alpha-Mediated Degradation of RAPGEF2. Dev Cell 2013; 27:574-85 (NKI) 991. Mahapatra D, Schueffler P, Tielbeek J, Makanyanga J, Stoker J, Taylor S, Vos F, Buhmann J. Automatic Detection and Segmentation of Crohn's Disease Tissues From Abdominal MRI. IEEE Transactions on Medcial Imaging 32(12), 2013, p.2332-2347. (AMC) 992. Mahmoudpour SH, Leusink M, van der Putten L, Terreehorst I, Asselbergs FW, de Boer A, van der Zee A. Pharmacogenetics of ACE inhibitor-induced angioedema and cough: a systematic review and meta- analysis. Pharmacogenomics 2013; 14: 249-260. (VUmc) 993. Maia ARR, Zhu X, Miller P, Gu G, Maiato H, Kaverina I. Modulation of Golgi-associated microtubule nucleation throughout the cell cycle. Cytoskeleton 2013; 70:32-43 (NKI)
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994. Majewski IJ, Kluijt I, Cats A, Scerri TS, De Jong D, Kluin RJC, Hansford S, Hogervorst FBL, Bosma AJ, Hofland I, Winter M, Huntsman D, Jonkers J, Bahlo M, Bernards R. An alpha-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. J Pathol 2013; 229:621-9 (NKI) 995. Majewski IJ, Mittempergher L, Davidson NM, Bosma A, Willems SM, Horlings HM, de Rink I, Greger L, Hooijer GK, Peters D, Nederlof PM, Hofland I, de Jong J, Wesseling J, Kluin RJc, Brugman W, Kerkhoven R, Nieboer F, Roepman P, Broeks A, Muley TR, Jassem J, Niklinski J, van Zandwijk N, Brazma A, Oshlack A, van den Heuvel M, Bernards R. Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing. Journal of Pathology 230(3), 2013, p.270-276. (AMC/NKI) 996. Makris NE, Huisman MC, Kinahan PE, Lammertsma AA, Boellaard R. Evaluation of strategies towards harmonization of FDG PET/CT studies in multicentre trials: comparison of scanner validation phantoms and data analysis procedures. Eur J Nucl Med Mol I 2013; 40: 1507-1515. (VUmc) 997. Malcovati L, Hellstrom-Lindberg E, Bowen D, Ades L, Cermak J, del Canizo C, la Porta MG, Fenaux P, Gattermann N, Germing U, Jansen JH, Mittelman M, Mufti G, Platzbecker U, Sanz GF, Selleslag D, Skov- Holm M, Stauder R, Symeonidis A, van de Loosdrecht AA, Witte T, Cazzola M. Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet. Blood 2013; 122: 2943-2964. (VUmc) 998. Malek Nisar P, Neumann Ulf P, Ricke J, Berg T, Bruns Ch, Denecke T, Klumpen H-J, Lippert H, Pech M, Peck-Radosavljevic M. Hepatocellular Carcinoma - an Interdisciplinary Disease Pattern. Viszeralmedizin 29(2), 2013, p.113-119. (AMC) 999. Mallaysamy S, Johnson MG, Rao PGM, Rajakannan T, Bathala L, Arumugam K, van Hasselt JGC, Ramakrishna D. Population pharmacokinetics of lamotrigine in Indian epileptic patients. Eur J Clin Pharmacol 2013; 69:43-52 (NKI) 1000. Malogajski J, Brankovic I, Verweij SP, Ambrosino E, van Agtmael MA, Brand A, Ouburg S, Morré SA. Translational Potential into Health Care of Basic Genomic and Genetic Findings for Human Immunodeficiency Virus, Chlamydia trachomatis, and Human Papilloma Virus. Biomed research international 2013; : . (VUmc) 1001. Malogolowkin M, Spreafico F, Dome JS, Van Tinteren H, Pritchard-Jones K, Heuvel-Eibrink MM, Bergeron C, de Kraker J, Graf N. Incidence and outcomes of patients with late recurrence of Wilms' tumor. Pediatr Blood Cancer 2013; 60:1612-5 (NKI) 1002. Mamoulakis C, Schulze M, Skolarikos A, Alivizatos G, Scarpa RM, Rassweiler JJ, de La Rosette JJMCH, Scoffone CM. Reply from Authors re: Alexander Bachmann, Gordon H. Muir, Stephen F. Wyler, Malte Rieken. Surgical Benign Prostatic Hyperplasia Trials: The Future is Now! Eur Urol 2013;63:677-9: Best Available Evidence in 2012 on Bipolar Versus Monopolar Transurethral Resection of the Prostate for Benign Prostatic Obstruction: It's About Time to Decide!. European Urology 63(4), 2013, p.679-680.
1003. Mamoulakis C, Schulze M, Skolarikos A, Alivizatos G, Scarpa RM., Rassweiler JJ, de La Rosette JJMCH, Scoffone CM. Midterm results from an international multicentre randomised controlled trial comparing bipolar with monopolar transurethral resection of the prostate. European Urology 63(4), 2013, p.667-676. (AMC) 1004. Mamoulakis C, Skolarikos A, Schulze M, Scoffone CM, Rassweiler JJ, Alivizatos G, Scarpa RM, de La Rosette JJMCH. Bipolar vs monopolar transurethral resection of the prostate: evaluation of the impact on overall sexual function in an international randomized controlled trial setting. BJU International 112(1), 2013, p.109-120. (AMC) 1005. Mamoulakis C, Ubbink DT, Sofras F, N'dow JMO, de La Rosette JJMCH. Re: Huang et al.: Bipolar transurethral resection of the prostate causes deeper coagulation depth and less bleeding than monopolar transurethral prostatectomy (Urology 2012;80:1116-1120). Urology 81(5), 2013, p.1113-1115. (AMC) 1006. Mancardi DA, Albanesi M, Jonsson F, Iannascoli B, van Rooijen N, Kang XQ, England P, Daeron M, Bruhns P. The high-affinity human IgG receptor Fc gamma RI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy. Blood 2013; 121: 1563-1573. (VUmc) 1007. Mann RM, Bult P, van Laarhoven HWM, Span PN, Schlooz M, Veltman J, Hoogerbrugge N. Breast cancer size estimation with MRI in BRCA mutation carriers and other high risk patients. European Journal of Radiology 82(9), 2013, p.1416-1422. (AMC) 1008. Marchetti S, Pluim D, Van Eijndhoven M, van Tellingen O, Mazzanti R, Beijnen JH, Schellens JHM. Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy- QPA. Invest New Drugs 2013; 31:1125-35 (NKI) 1009. Marchiando AM, Ramanan D, Ding Y, Gomez LE, Hubbard-Lucey VM, Maurer K, Wang C, Ziel JW, van Rooijen N, Nunez G, Finlay BB, Mysorekar IU, Cadwell K. A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. Cell Host & Microbe 2013; 14: 216-224. (VUmc) 1010. Margadant C, Cremers L, Sonnenberg A, Boonstra J. MAPK uncouples cell cycle progression from cell spreading and cytoskeletal organization in cycling cells. Cell Mol Life Sci 2013; 70:293-307 (NKI) 1011. Margadant C, Kreft M, Zambruno G, Sonnenberg A. Kindlin-1 Regulates Integrin Dynamics and Adhesion Turnover. PLoS One 2013; 8:e65341 (NKI)
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1012. Marres H, Lohuis PJFM. Aandoeningen van de nervus facialis. In: de Vries N, van de Heyning PH, Leemans CR (eds). Leerboek keel-neus-oorheelkunde en hoofd-halschirurgie, 2e dr. Houten: Bohn Stafleu Van Loghum, 2013: p. 129-143 (NKI) 1013. Marshall GM, la Pozza L, Sutton R, Ng A, de Groot-Kruseman H, van der Velden VH, Venn NC, van den Berg H, De Bont ESJM, Egeler RM, Hoogerbrugge PM, Kaspers GJL, Bierings MB, van der Schoot E, van Dongen J, Law T, Cross S, Mueller H, de Haas V, Haber M, Revesz T, Alvaro F, Suppiah R, Norris MD, Pieters R. High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation. Leukemia 2013; 27: 1497-1503. (VUmc/AMC) 1014. Marsman AF, Dahmen R, Roorda LD, van Schaardenburg D, Dekker J, Britsemmer K, Knol DL, van der Leeden M. Foot-related health care use in patients with rheumatoid arthritis in an outpatient secondary care center for rheumatology and rehabilitation in the Netherlands: A cohort study with a maximum of fifteen years of followup. Arthritis Care Res 2013; 65: 220-226. (VUmc) 1015. Marsman HA, de Graaf W, Heger M, van Golen RF, ten Kate FJW, Bennink R, van Gulik TM. Hepatic regeneration and functional recovery following partial liver resection in an experimental model of hepatic steatosis treated with omega-3 fatty acids. British Journal of Surgery 100(5), 2013, p.674-683. 1016. Martin JE, Assassi S, az-Gallo LM, Broen JC, Simeon CP, Castellvi I, Vicente-Rabaneda E, Fonollosa V, Ortego-Centeno N, Gonzalez-Gay MA, Espinosa G, Carreira P, Camps M, Sabio JM, D'Alfonso S, Vonk MC, Voskuyl AE, Schuerwegh AJ, Kreuter A, Witte T, Riemekasten G, Hunzelmann N, Airo P, Beretta L, Scorza R, Lunardi C, van Laar J, Chee MM, Worthington J, Herrick A, Denton C, Fonseca C, Tan FK, Arnett F, Zhou XD, Reveille JD, Gorlova O, Koeleman BPC, Radstake TRDJ, Vyse T, Mayes MD, arcon- Riquelme ME, Martin J. A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. Hum Mol Genet 2013; 22: 4021-4029. (VUmc) 1017. Martino J, Hamer PC, Berger MS, Lawton MT, Arnold CM, de Lucas EM, Duffau H. Analysis of the subcomponents and cortical terminations of the perisylvian superior longitudinal fasciculus: a fiber dissection and DTI tractography study. Brain Structure and Function 2013; 218: 105-121. (VUmc) 1018. 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Improving intracellular doxorubicin delivery through nanoliposomes equipped with selective tumor cell membrane permeabilizing short-chain sphingolipids. Pharm Res 2013; 30:1883-95 (NKI) 1183. Pegtel DM. Oncogenic herpesviruses sending mixed signals. P Natl Acad SCI USA 2013; 110: 12503-12504. (VUmc) 1184. Peguret N, Dahele MR, Cuijpers JP, Slotman BJ, Verbakel WFAR. Frameless high dose rate stereotactic lung radiotherapy: Intrafraction tumor position and delivery time. Radiather Oncol 2013; 107: 419-422. (VUmc) 1185. Peguret N, Dahele MR, Slotman BJ, Verbakel WFAR. RPM tracing for the detection of changes in lung tumor position: In response to Alderliesten et al. Radiother Oncol 2012;105(2): 155-60. Radiather Oncol 2013; 107: 261-262. (VUmc) 1186. Pellissier LP, Alves Celso H, Quinn PM, Vos RM, Tanimoto N, Lundvig DMS, Dudok JJ, Hooibrink B, Richard F, Beck SC, Huber G, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, Wijnholds J. Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis. PLOS Genetics 9(12), 2013, p.e1003976-. (AMC) 1187. Penders J, Stobberingh EE, Savelkoul PHM, Wolffs PF. The human microbiome as a reservoir of antimicrobial resistance. Frontiers in Microbiology 2013; 4: 87. (VUmc) 1188. Penel N, Demetri GD, Blay JY, Cousin S, Maki RG, Chawla SP, Judson I, von Mehren M, Schoffski P, Verweij J, Casali P, Rodenhuis S, Schutte HJ, Cassar A, Gomez J, Nieto A, Zintl P, Pontes MJ, Le Cesne A. Growth modulation index as metric of clinical benefit assessment among advanced soft tissue sarcoma patients receiving trabectedin as a salvage therapy. Ann Oncol 2013; 24:537-42 (NKI) 1189. Peng M, Bakker JL, Dicioccio RA, Gille JJ, Zhao H, Odunsi K, Sucheston L, Jaafar L, Mivechi NF, Waisfisz Q, Ko L. Inactivating Mutations in GT198 in Familial and Early-Onset Breast and Ovarian Cancers. Genes, Chromosomes & Cancer 2013; 4: 15-25. (VUmc) 1190. Pennock S, Kim D, Mukai S, Kuhnle M, Chun DW, Matsubara J, Cui J, Ma P, Maberley D, Samad A, van Geest RJ, Oberstein SL, Schlingemann RO, Kazlauskas A. Ranibizumab is a potential prophylaxis for proliferative vitreoretinopathy, a nonangiogenic blinding disease. American Journal of Pathology 182(5), 2013, p.1659-1670. (AMC) 1191. Peperzak V, Veraar EAM, Xiao Y, Babala N, Thiadens K, Brugmans M, Borst J. CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool. J Immunol 2013; 191:3025-36 (NKI) 1192. Peperzak V, Veraar EAM, Xiao Y, Babala N, Thiadens K, Brugmans M, Borst J. CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool. Journal of Immunology 191(6), 2013, p.3025-3036. (AMC/NKI) 1193. Peperzak V, Vikström I, Walker J, Glaser SP, LePage M, Coquery CM, Erickson LD, Fairfax K, Mackay F, Strasser A, Nutt SL, Tarlinton DM. Mcl-1 is essential for the survival of plasma cells. Nature Immunology 14(3), 2013, p.290-297. (AMC) 1194. Permuth-Wey J et al. Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nat Commun 2013; 4:1627-(23 pp) (NKI) 1195. Persoon S, Kersten MJ, van der Weiden K, Buffart LM, Nollet F, Brug J, Chinapaw MJM. Effects of exercise in patients treated with stem cell transplantation for a hematologic malignancy: a systematic review and meta-analysis. Cancer Treatment Reviews 39(6), 2013, p.682-690. (AMC) 1196. Peters EJG, Lipsky BA. Diagnosis and Management of Infection in the Diabetic Foot. Med Clinics of North America 2013; 97: 911-946. (VUmc)
Scientific publications - 141
1197. Peters GJ, Galvani E, Jansen G, Assaraf Y, Giovannetti E. Thymidylate synthase inhibitors for thoracic tumors. Pteridines 2013; 24: 57-67. (VUmc) 1198. Peters GJ, Kathmann I, Lemos C, Hooijberg JH, Losekoot N, Jansen G. Folate homeostasis of cancer cells affects sensitivity to not only antifolates but also other non-folate drugs: effect of MRP expression. Pteridines 2013; 24: 81-86. (VUmc) 1199. Peters GJ, Smid K, Vecchi L, Kathmann I, Sarkisjan D, Honeywell RJ, Losekoot N, Ohne O, Orbach A, Blaugrund E, Jeong LS, Lee YB, Ahn CH, Kim DJ. Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360). Invest New Drug 2013; 31: 1444-1457. (VUmc) 1200. Peters GJ. Cancer therapeutics and research: novel developments. J Cancer Ther & Res 2013; : 2. (VUmc) 1201. Peters M, Moman MR, van der Poel HG, Vergunst H, de Jong IJ, Vijverberg PL, Battermann JJ, Horenblas S, van Vulpen M. Patterns of outcome and toxicity after salvage prostatectomy, salvage cryosurgery and salvage brachytherapy for prostate cancer recurrences after radiation therapy: a multi-center experience and literature review. World J Urol 2013; 31:403-9 (NKI) 1202. Petersen MA, Aaronson NK, Arraras JI, Chie WC, Conroy T, Costantini A, Giesinger JM, Holzner B, King MT, Singer S, Velikova G, Verdonck-de Leeuw IM, Young T, Groenvold M. The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency. J Clin Epidemiol 2013; 66: 330-339. (VUmc/NKI) 1203. Petersen MA, Giesinger JM, Holzner B, Arraras JI, Conroy T, Gamper EM, King MT, Verdonck-de Leeuw IM, Young T, Groenvold M. Psychometric evaluation of the EORTC computerized adaptive test (CAT) fatigue item pool. Qual Life Res 2013; 22: 2443-2454. (VUmc) 1204. Phillips KA, Milne RL, Rookus MA, Daly MB, Antoniou AC, Peock S, Frost D, Easton DF, Ellis S, Friedlander ML, Buys SS, Andrieu N, Nogues C, Stoppa-Lyonnet D, Bonadona V, Pujol P, McLachlan SA, John EM, Hooning MJ, Seynaeve C, Tollenaar RA, Goldgar DE, Terry MB, Caldes T, Weideman PC, Andrulis IL, Singer CF, Birch K, Simard J, Southey MC, Olsson HL, Jakubowska A, Olah E, Gerdes AM, Foretova L, Hopper JL. Tamoxifen and risk of contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. J Clin Oncol 2013; 31:3091-9 (NKI) 1205. Phillips RM, Hendriks HR, Peters GJ. EO9 (Apaziquone): from the clinic to the laboratory and back again. Brit J Pharmacol 2013; 168: 11-18. (VUmc) 1206. Phoa K. N, Pouw RE, van Vilsteren FGI, Sondermeijer CMT, ten Kate FJW, Visser M, Meijer SL, van Berge Henegouwen MI, Weusten BLAM, Schoon EJ, Mallant-Hent RC, Bergman JJGHM. Remission of Barrett's esophagus with early neoplasia 5 years after radiofrequency ablation with endoscopic resection: a Netherlands cohort study. Gastroeenterology 145(1), 2013, p.96-104. (AMC) 1207. Piersma SR, Warmoes MO, de Wit M, de Reus I, Knol JC, Jimenez CR. Whole gel processing procedure for GeLC-MS/MS based proteomics. Proteome Sci 2013; 11: . (VUmc) 1208. Pieters BR, Koning CCE, Horenblas S. Re: does partial cystectomy compromise oncologic outcomes for patients with bladder cancer compared to radical cystectomy? A matched case-control analysis. Journal of Urology 189(4), 2013, p.1600-1601. (AMC/NKI) 1209. Pieterse QD, Kenter GG, Maas CP, de Kroon CD, Creutzberg CL, Trimbos JB, ter Kuile MM. Self-reported sexual, bowel and bladder function in cervical cancer patients following different treatment modalities: longitudinal prospective cohort study. Int J Gynecol Cancer 2013; 23: 1717-1725. (VUmc) 1210. Pijpe A, Rookus M, Bruinvels D. Nachtwerk na borstkanker: verstandig of niet? Evidence over nachtwerk en de kans op (terugkeer van) borstkanker. Tijdschrift voor Bedrijfs- en Verzekeringsgeneeskunde 2013; 21:345-50 (NKI) 1211. Pires PW, Girgla SS, McClain JL, Kaminski NE, van Rooijen N, Dorrance AM. Improvement in Middle Cerebral Artery Structure and Endothelial Function in Stroke-Prone Spontaneously Hypertensive Rats after Macrophage Depletion. Microcirculation 2013; 20: 650-661. (VUmc) 1212. Pistilli B, Bellettini G, Giovannetti E, Codacci-Pisanelli G, Azim HA, Benedetti G, Sarno MA, Peccatori FA. Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about breastfeeding?. Cancer Treat Rev 2013; 39: 207-211. (VUmc) 1213. Plat Marie-CJ, Westerveld GJ, Hutter RC, Olff M, Frings-Dresen MHW, Sluiter JK. Return to work: Police personnel and PTSD. Work- A Journal of Prevention Assessement & Rehabilitation 46(1), 2013, p.107-111. (AMC) 1214. Ploos van Amstel FK, van den Berg SW, van Laarhoven HWM, Gielissen MFM, Prins JB, Ottevanger PB. Distress screening remains important during follow-up after primary breast cancer treatment. Supportive Care in Cancer 21(8), 2013, p.2107-2115. (AMC) 1215. PLOS ONE 8(9), 2013, p.e73125-. (AMC) 1216. Plotkin SR, Blakeley JO, Evans DG, Hanemann CO, Hulsebos TJM, Hunter-Schaedle K, Kalpana GV, Korf B, Messiaen L, Papi L, Ratner N, Sherman LS, Smith MJ, Stemmer-Rachamimov AO, Vitte J, Giovannini M. Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria. American Journal of Medical Genetics Part A.161A(3), 2013, p.405-416. (AMC) 1217. Pluim D, Jacobs BA, Krahenbuhl MD, Ruijter AE, Beijnen JH, Schellens JH. Correction of peripheral blood mononuclear cell cytosolic protein for hemoglobin contamination. Anal Bioanal Chem 2013; 405:2391-5 (NKI)
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1218. Pluim D, Schilders KAA, Jacobs BAW, Vaartjes D, Beijnen JH, Schellens JHM. Pharmacodynamic assay of thymidylate synthase activity in peripheral blood mononuclear cells. Anal Bioanal Chem 2013; 405:2495- 503 (NKI) 1219. Polito M, Klarenbeek J, Jalink K, Paupardin-Tritsch D, Vincent P, Castro L. The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons. Front Cell Neurosci 2013; 7:211 (NKI) 1220. Poljak M, Rogovskaya SI, Kesic V, Bray F, Berkhof J, Seme K, Brotons M, Castellsague X, Syrjanen S, Arbyn M, Bosch FX. Recommendations for Cervical Cancer Prevention in Central and Eastern Europe and Central Asia. Vaccine 2013; 31: H80-H82. (VUmc) 1221. Pomykala KL, de Ruiter MB, Deprez S, McDonald BC, Silverman DHS. Integrating imaging findings in evaluating the post-chemotherapy brain. Brain Imag Behav 2013; 7:436-52 (NKI) 1222. Ponten A, alto-Korte K, Agner T, Andersen KE, Gimenez-Arnau AM, Goncalo M, Goossens A, Johansen JD, Le Coz CJ, Maibach HI, Rustemeyer T, White IR, Bruze M. Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allergy. Contact Dermatitis 2013; 68: 50-53. (VUmc) 1223. Poot AJ, Slobbe P, Hendrikse NH, Windhorst AD, van Dongen GAMS. Imaging of TKI-Target Interactions for Personalized Cancer Therapy. Clin Pharmacol Ther 2013; 93: 239-241. (VUmc) 1224. Poot AJ, van der Wildt B, Stigter-van Walsum M, Rongen M, Schuit RC, Hendrikse NH, Eriksson PAJ, van Dongen GAMS, Windhorst AD. [C-11]Sorafenib: Radiosynthesis and preclinical evaluation in tumor- bearing mice of a new TKI-PET tracer. Nucl Med Biol 2013; 40: 488-497. (VUmc) 1225. Post ICJH, de Boon WMI, Heger M, van Wijk ACWA, Kroon J, van Buul JD, van Gulik TM. Endothelial cell preservation at hypothermic to normothermic conditions using clinical and experimental organ preservation solutions. Experimental Cell Research 319(17), 2013, p.2501-2513. (AMC) 1226. Post ICJH, Dirkes MC, Heger M, Verheij J, de Bruin KM, de Korte D, Bennink RJ, van Gulik TM. Efficacy of liver graft washout as a function of the perfusate, pressure, and temperature. Liver Transplantation 19(8), 2013, p.843-851. (AMC) 1227. Post ICJH, Weenink RP, van Wijk ACWA, Heger M, Böing AN, van Hulst RA, van Gulik TM. Characterization and quantification of porcine circulating endothelial cells. Xenotransplantation 20(1), 2013, p.18-26. (AMC) 1228. Postel R, Margadant C, Fischer B, Kreft M, Janssen H, Secades P, Zambruno G, Sonnenberg A. Kindlin-1 mutant zebrafish as an in vivo model system to study adhesion mechanisms in the epidermis. J Invest Dermatol 2013; 133:2180-90 (NKI) 1229. Posthuma de Boer J, Piersma SR, Pham TV, van Egmond PW, Knol JC, Cleton-Jansen AM, van Geer MA, van Beusechem VW, Kaspers GJL, van Royen BJ, Jimenez CR, Helder MN. Surface proteomic analysis of osteosarcoma identifies EPHA2 as receptor for targeted drug delivery. Brit J Cancer 2013; 109: 2142- 2154. (VUmc) 1230. Postma TJ, Reijneveld JC, Heimans JJ. Prevention of chemotherapy-induced peripheral neuropathy: a matter of personalized treatment?. Ann Oncol 2013; 24: 1424-1426. (VUmc) 1231. Postnov A, Froklage FE, van Lingen A, Reijneveld JC, Hendrikse NH, Windhorst AD, Schuit RC, Eriksson PAJ, Lammertsma AA, Huisman MC. Radiation Dose of the P-Glycoprotein Tracer C-11-Laniquidar. J Nucl Med 2013; 54: 2101-2103. (VUmc) 1232. Potrykus J, Stead D, MacCallum DM, Urgast DS, Raab A, van Rooijen N, Feldmann J, Brown AJP. Fungal Iron Availability during Deep Seated Candidiasis Is Defined by a Complex Interplay Involving Systemic and Local Events. PLoS Pathog 2013; : 9. (VUmc) 1233. Pouw RE, Bergman JJGHM. Radiofrequency ablation for Barrett's esophagus, for whom and by whom? Clinical Gastroenterology and Hepatology 11(10), 2013, p.1256-1258. (AMC) 1234. Powles T, Kayani I, Sharpe K, Lim L, Peters J, Stewart GD, Berney D, Sahdev A, Chowdhury S, Boleti E, Shamash J, Reynolds AR, Jones R, Blank C, Haanen J, Bex A. A prospective evaluation of VEGF-targeted treatment cessation in metastatic clear cell renal cancer. Ann Oncol 2013; 24:2098-103 (NKI) 1235. Prasad VVSR, Reddy GD, Appaji D, Peters GJ, Mayur YC. Chemosensitizing acridones: In vitro calmodulin dependent cAMP phosphodiesterase inhibition, docking, pharmacophore modeling and 3D QSAR studies. J Mol Graph Model 2013; 40: 116-124. (VUmc) 1236. Prasetyanti PR, Zimberlin CD, Bots M, Vermeulen L, Melo Felipe De Sousa E, Medema JP. Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon. Molecular Cancer 12(1), 2013, p.126-. (AMC) 1237. Prinsen H, Bleijenberg G, Heijmen L, Zwarts MJ, Leer JWH, Heerschap A, Hopman MTE, van Laarhoven HWM. The role of physical activity and physical fitness in postcancer fatigue: a randomized controlled trial. Supportive Care in Cancer 21(8), 2013, p.2279-2288. (AMC) 1238. Prinsen H, Heerschap A, Bleijenberg G, Zwarts MJ, Leer JWH, van Asten JJ, van der Graaf M, Rijpkema M, van Laarhoven HWM. Magnetic resonance spectroscopic imaging and volumetric measurements of the brain in patients with postcancer fatigue: a randomized controlled trial.PLOS ONE 8(9), 2013, p.e74638-. (AMC) 1239. Prinsen H, Hopman MTE, Zwarts MJ, Leer JWH, Heerschap A, Bleijenberg G, van Laarhoven HWM. Maximal exercise performance in patients with postcancer fatigue. Supportive Care in Cancer 21(2), 2013, p.439-447. (AMC) 1240. Prokopakis E, Vardouniotis A, Kawauchi H, Scadding G, Georgalas C, Hellings P, Velegrakis G, Kalogjera
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L. The pathophysiology of the hygiene hypothesis. International Journal of Pediatric Otorhinolaryngology 77(7), 2013, p.1065-1071. (AMC) 1241. Proskocil BJ, Bruun DA, Jacoby DB, van Rooijen N, Lein PJ, Fryer AD. Macrophage TNF-alpha mediates parathion-induced airway hyperreactivity in guinea pigs. Am J Physiol Lung Cell Mol Physiol 2013; 304: L519-L529. (VUmc) 1242. Prowse RL, Dalbeth N, Kavanaugh A, Adebajo AO, Gaffo AL, Terkeltaub R, Mandell BF, Suryana BPP, Goldenstein-Schainberg C, az-Torne C, Khanna D, Liote F, Mccarthy G, Kerr GS, Yamanaka H, Janssens H, Baraf HF, Chen JH, Vazquez-Mellado J, Harrold LR, Stamp LK, van de Laar MA, Janssen M, Doherty M, Boers M, Edwards NL, Gow P, Chapman P, Khanna P, Helliwell PS, Grainger R, Schumacher HR, Neogi T, Jansen TL, Louthrenoo W, Sivera F, Taylor WJ. A Delphi Exercise to Identify Characteristic Features of Gout - Opinions from Patients and Physicians, the First Stage in Developing New Classification Criteria. J Rheumatol 2013; 40: 498-505. (VUmc) 1243. Publicaties Vumc CCA 2013 1244. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest 2013; 123: 3728-3739. (VUmc) 1245. Pundir V, Pundir J, Georgalas C, Fokkens WJ. Role of tranexamic acid in endoscopic sinus surgery - A systematic review and meta-analysis. Rhinology 51(4), 2013, p.291-297. (AMC) 1246. Raaijmakers JA, Tanenbaum ME, Medema RH. Systematic dissection of dynein regulators in mitosis. J Cell Biol 2013; 201:201-15 (NKI) 1247. Rachmawati D, Bontkes HJ, Verstege MI, Muris J, von Blomberg BME, Scheper RJ, van Hoogstraten IMW. Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators. Contact Dermatitis 2013; 68: 331-338. (VUmc) 1248. Rademakers SE, Hoogsteen IJ, Rijken PF, Oosterwijk E, Terhaard CH, Doornaert PAH, Langendijk JA, van den Ende P, Takes R, de Bree R, van der Kogel AJ, Bussink J, Kaanders JH. Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial. Radiather Oncol 2013; 108: 517-522. (VUmc) 1249. Rajan A, Caldas C, van Luenen H, Saghatchian M, Van Harten WH. Assessing excellence in translational cancer research: a consensus based framework. J Transl Med 2013; 11:274 (NKI) 1250. Ramirez-Ardila DE, Helmijr JC, Look MP, Lurkin I, Ruigrok-Ritstier K, Van Laere S, Dirix L, Sweep FC, Span PN, Linn SC, Foekens JA, Sleijfer S, Berns EMJJ, Jansen MPHM. Hotspot mutations in PIK3CA associate with first-line treatment outcome for aromatase inhibitors but not for tamoxifen. Breast Cancer Res Treat 2013; 139:39-49 (NKI) 1251. Ramos P, Casu C, Gardenghi S, Breda L, Crielaard BJ, Guy E, Marongiu MF, Gupta R, Levine RL, bdel- Wahab O, Ebert BL, van Rooijen N, Ghaffari S, Grady RW, Giardina PJ, Rivella S. Macrophages support pathological erythropoiesis in polycythemia vera and beta-thalassemia. Nat Med 2013; 19: 437-445. (VUmc) 1252. Rassweiler J, Laguna P, Chlosta P, Pansadoro V, Gaboardi F, Stolzenburg J-U, Barret E, Liatiskos E, Tunc L, Frede T, John , Bachmann A, van Velthoven R: ESUT expert group on laparoscopy proposes uniform terminology during radical prostatectomy: we need to speak the same language. European Urology 64(1), 2013, p.97-100. (AMC) 1253. Raterman HG, Levels H, Voskuyl AE, Lems WF, Dijkmans BAC, Nurmohamed MT. HDL protein composition alters from proatherogenic into less atherogenic and proinflammatory in rheumatoid arthritis patients responding to rituximab. Ann Rheum Dis 2013; 72: 560-565. (VUmc)
1254. Raterman HG, Voskuyl AE, Simsek S, Schreurs MWJ, van Hoogstraten IMW, Peters MJL, van Halm VP, Dijkmans BAC, Lips P, Lems WF, Nurmohamed MT. Increased progression of carotid intima media thickness in thyroid peroxidase antibodies-positive rheumatoid arthritis patients. Eur J Endocrinol 2013; 169: 751-757. (VUmc) 1255. Reeve BB, Wyrwich KW, Wu AW, Velikova G, Terwee CB, Snyder CF, Schwartz C, Revicki DA, Moinpour CM, McLeod LD, Lyons JC, Lenderking WR, Hinds PS, Hays RD, Greenhalgh J, Gershon R, Feeny D, Fayers PM, Cella D, Brundage M, Ahmed S, Aaronson NK, Butt Z. ISOQOL recommends minimum standards for patient-reported outcome measures used in patient-centered outcomes and comparative effectiveness research. Qual Life Res 2013; 22:1889-905 (NKI) 1256. Regelink JC, Minnema MC, Terpos E, Kamphuis MH, Raijmakers PGHM, van den Pieters-van den Bos, Heggelman BGF, Nievelstein RJ, Otten RHJ, van Lammeren-Venema D, Zijlstra JM, Arens AIJ, de Rooy JW, Hoekstra OS, Raymakers R, Solleveld P, Ostelo RWJG, Zweegman S. Comparison of modern and conventional imaging techniques in establishing multiple myeloma-related bone disease: a systematic review. Brit J Haematol 2013; 162: 50-61. (VUmc) 1257. Reijmers RM, Spaargaren M, Pals ST. Heparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myeloma. FEBS Journal 280(10), 2013, p.2180-2193. (AMC) 1258. Reiling J, Olive A, Sanyal S, Carette J, Brummelkamp T, Ploegh H, Starnbach M, Sabatini D. A CREB3- ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens. Nat Cell Biol 2013; 15:1473-85 (NKI) 1259. Reinders JSK, Gouma DJ, Heisterkamp J, Tromp E, van Ramshorst B, Boerma D. Laparoscopic
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Van der Palen RLF, Bulten BF, Mavinkurve-Groothuis AMC, Bellersen L, van Laarhoven HWM, Kapusta L, de Geus-Oei LF. Catecholamines influence myocardial 123I MIBG uptake in neuroblastoma patients. Nuklearmedizin-Nuclear Medicine 52(6), 2013, p.228-234. (AMC) 1622. van der Pas MH, Haglind E, Cuesta MA, Furst A, Lacy AM, Hop WC, Bonjer HJ. Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol 2013; 14: 210-218. (VUmc) 1623. van der Pas MHGM, Ankersmit M, Stockmann HBAC, Silvis R, van Grieken NCT, Bril H, Meijerink WJHJ. Laparoscopic sentinel lymph node identification in patients with colon carcinoma using a near-infrared dye: description of a new technique and feasibility study. J Laparoendoscopic & Advanced Surgical Techniques Part A 2013; 23: 367-371. (VUmc) 1624. van der Plas M, de Kemp SR, de Maaker M, van Wieringen WN, Ylstra B, Agami R, Cerisoli F, Leemans CR, Braakhuis BJM, Brakenhoff RH. 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1660. Van Drooge AM, Bosveld B, van der Veen JPW, de Rie MA, Wolkerstorfer A. Long-pulsed 1064 nm Nd:YAG laser improves hypertrophic port-wine stains. Journal of the Europlean Academy of Dermatology and Venereology 27(11), 2013, p.1381-1386. (AMC/NKI) 1661. Van Drooge AM, de Rie M, van der Veen W, Wolkerstorfer A. Port-wine stain progression: is prevention by pulsed dye laser therapy possible?. European Journal of Dermatology 23(2), 2013, p.282-283. (AMC) 1662. Van Dyk E, Reinders M, Wessels L. A scale-space method for detecting recurrent DNA copy number changes with analytical false discovery rate control. Nucleic Acids Res 2013; 41:e100 (NKI) 1663. van Egmond M, Bakema JE. Neutrophils as effector cells for antibody-based immunotherapy of cancer. Semin Cancer Biol 2013; 23: 190-199. (VUmc) 1664. van Egmond ME, Pouwels PJW, Boelens JJ, Lindemans CA, Barkhof F, Steenwijk MD, van Hasselt PM, van der Knaap MS, Wolf NI. Improvement of White Matter Changes on Neuroimaging Modalities After Stem Cell Transplant in Metachromatic Leukodystrophy. JAMA Neurology 2013; 70: 779-782. (VUmc) 1665. van El CG, Cornel MC, Borry P, Hastings RJ, Fellmann F, Hodgson SV, Howard HC, Cambon-Thomsen A, Knoppers BM, Meijers-Heijboer H, Scheffer H, Tranebjaerg L, Dondorp W, De Wert GMWR. Whole- genome sequencing in health care Recommendations of the European Society of Human Genetics. Eur J Hum Genet 2013; 21: 580-584. (VUmc/AMC) 1666. van Empel PJ, van Rijssen LB, Commandeur JP, Verdam MGE, Huirne JA, Scheele G, Bonjer HJ, Meijeringk WJ. Objective versus subjective assessment of laparoscopic skill. ISRN Minimal Invasive Surg 2013; : 686494. (VUmc) 1667. van Exel E, Jacobs J, Korswagen LA, Voskuyl AE, Stek ML, Dekker J, Bultink IEM. Depression in systemic lupus erythematosus, dependent on or independent of severity of disease. Lupus 2013; 22: 1462-1469. (VUmc) 1668. van Geenen EJM, van Santvoort HC, Besselink MGH, van der Peet DL, van Erpecum KJ, Fockens P, Mulder CJJ, Bruno MJ. Lack of Consensus on the Role of Endoscopic Retrograde Cholangiography in Acute Biliary Pancreatitis in Published Meta-Analyses and Guidelines: A Systematic Review. Pancreas 2013; 42: 774- 780. (VUmc) 1669. van Gerven NMF, de Boer YS, Zwiers A, van Hoek B, van Erpecum KJ, Beuers U, van Buuren HR, Drenth JP, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Bloemena E, Vrolijk JM, Kraal G, Mulder CJJ, van Nieuwkerk CMJ, Bouma G. Cytotoxic T lymphocyte antigen-4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis. Liver International 2013; 33: 1039-1043. (VUmc) 1670. van Gerven NMF, Verwer BJ, Witte BI, van Hoek B, Coenraad MJ, van Erpecum KJ, Beuers U, van Buuren HR, de Man RA, Drenth JPH, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MMJ, Mulder CJJ, van Nieuwkerk KMJ, Bouma G. Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission. J Hepatol 2013; 58: 141-147. (VUmc) 1671. Van Gestel D, Vliet-Vroegindeweij C, Van den Heuvel F, Crijns W, Coelmont A, De Ost B, Holt A, Lamers E, Geussens Y, Nuyts S, Van den Weyngaert D, Van den Wyngaert T, Vermorken JB, Gregoire V. RapidArc, SmartArc and TomoHD compared with classical step and shoot and sliding window intensity modulated radiotherapy in an oropharyngeal cancer treatment plan comparison. Radiat Oncol 2013; 8:37 (NKI) 1672. Van Gijn W, Brehm V, de Graaf E, Neijenhuis PA, Stassen LPS, Leijtens JWA, Van De Velde CJH, Doornebosch PG. Unexpected rectal cancer after TEM: Outcome of completion surgery compared with primary TME. Eur J Surg Oncol 2013; 39:1225-9 (NKI) 1673. Van Gils CWM, de Groot S, Redekop WK, Koopman M, Punt CJA, Uyl-de Groot CA. Real-World Cost-Effectiveness of Oxaliplatin in Stage III Colon Cancer: A Synthesis of Clinical Trial and Daily Practice Evidence. Pharmacoeconomics 31(8), 2013, p.703-718. (AMC) 1674. van Gils RF, Bosmans JE, Boot CRL, Rustemeyer T, van Mechelen W, Valk PGM, Anema JR. Economic evaluation of an integrated care programme for patients with hand dermatitis. Contact Dermatitis 2013; 69: 144-152. (VUmc) 1675. Van Golen RF, Reiniers MJ, Olthof PB, van Gulik TM, Heger M. Sterile inflammation in hepatic ischemia/reperfusion injury: present concepts and potential therapeutics. Journal of Gastroenterology and Hepatology 28(3), 2013, p.394-400. (AMC) 1676. van Grieken NCT, Aoyma T, Chambers PA, Bottomley D, Ward LC, Inam I, Buffart TE, Das K, Lim T, Pang B, Zhang SL, Tan IB, Carvalho B, Heideman DAM, Miyagi Y, Kameda Y, Arai T, Meijer GA, Tsuburaya A, Tan P, Yoshikawa T, Grabsch HI. KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: Results from a large international multicentre study. Brit J Cancer 2013; 108: 1495-1501. (VUmc/NKI) 1677. Van Halsema EE, van Hooft JE. Removing in situ esophageal stents Response. Gastrointestinal Endoscopy 78(1), 2013, p.192-. (AMC) 1678. Van Halsema EE, Wong Kee Song LM, Baron TH, Siersema PD, Vleggaar FP, Ginsberg GG, Shah PM, Fleischer DE, Ratuapli SK, Fockens P, Dijkgraaf MGW, Rando G, Repici A, van Hooft JE. Safety of endoscopic removal of self-expandable stents after treatment of benign esophageal diseases. Gastrointestinal Endoscopy 77(1), 2013, p.18-28. (AMC) 1679. Van Harten WH, Paradiso A, Le Beau MM. The role of comprehensive cancer centers in survivorship care. Cancer 2013; 119:2200-1 (NKI) 1680. Van Harten WH. Trends in kwaliteitsmanagement in de gezondheidszorg - Breder, van intern naar extern en op weg naar houdbaarheid... 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1681. Van Hasselt JG, van Eijkelenburg NK, Beijnen JH, Schellens JH, Huitema AD. Optimizing drug development of anti-cancer drugs in children using modelling and simulation. Br J Clin Pharmacol 2013; 76:30-47 (NKI) 1682. Van Hasselt JGC, Gupta A, Hussein Z, Beijnen JH, Schellens JHM, Huitema ADR. Population pharmacokinetic-pharmacodynamic analysis for eribulin mesilate-associated neutropenia. Br J Clin Pharmacol 2013; 76:412-24 (NKI) 1683. Van Hasselt JGC, van Eijkelenburg NK., Beijnen JH., Schellens JHM, Huitema ADR. Optimizing drug development of anti-cancer drugs in children using modelling and simulation. Britisch Journal of Clinical Pharmacology 76(1), 2013, p.30-47. (AMC/NKI) 1684. Van Hasselt JGC, van Eijkelenburg NKA, Huitema ADR, Schellens JHM, Schouten-van Meeteren AYN. Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate. Antimicrobial Agents and Chemotherapy 57(6), 2013, p.2878-2881. (AMC/NKI) 1685. Van Heesbeen RGHP, Raaijmakers JA, Tanenbaum ME, Medema RH. Nuclear envelope-associated dynein cooperates with Eg5 to drive prophase centrosome separation. Commun Integr Biol 2013; 6:e23841 (NKI) 1686. Van Heijningen E-MB, Lansdorp-Vogelaar I, Kuipers EJ, Dekker E, Lesterhuis W, ter Borg F, Vecht J, de Jonge V, Spoelstra P, Engels L, Bolwerk CJM, Timmer R, Kleibeuker JH, Koornstra JJ, van Ballegooijen M, Steyerberg EW. Features of adenoma and colonoscopy associated with recurrent colorectal neoplasia based on a large community-based study. Gastroenterology 144(7), 2013, p.1410-1418. (AMC) 1687. Van Hell A, Melo M, van Blitterswijk W, Gueth D, Braumuller T, Pedrosa L, Song J, Marrink S, Koning G, Jonkers J, Verheij M. Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance. Sci Rep 2013; 3:1949 (NKI) 1688. Van Hemert FJ, van der Kuyl AC, Berkhout B. The A-nucleotide preference of HIV-1 in the context of its structured RNA genome. RNA Biology 10(2), 2013, p.211-215.(AMC) 1689. Van Heumen BWH, Roelofs HMJ, Vink-Börger ME, Dekker E, Mathus-Vliegen EMH, Dees J, Koornstra JJ, Langers AMJ, Nagtegaal ID, Kampman E, Peters WHM, Nagengast FM. Ursodeoxycholic acid counteracts celecoxib in reduction of duodenal polyps in patients with familial adenomatous polyposis: a multicentre, randomized controlled trial. Orphanet Journal of Rare Diseases 8(1), 2013, p.118-. (AMC) 1690. Van Houdt P, Zijlmans M. Different ways to analyze EEG-fMRI in focal epilepsy: Does it matter? Clin Neurophysiol 2013; 124:2070-2 (NKI) 1691. Van Huis Tanja LH, Gelderblom H, Punt CJA, Guchelaar H-J. MTHFR polymorphisms and capecitabine-induced toxicity in patients with metastatic colorectal cancer. Pharmacogenetics and Genomics 23(4), 2013, p.208-218. (AMC) 1692. Van Huis-Tanja L, Kweekel D, Gelderblom H, Koopman M, Punt K, Guchelaar H-J, van der Straaten T. Concordance of genotype for polymorphisms in DNA isolated from peripheral blood and colorectal cancer tumor samples. Pharmacogenomics 14(16), 2013, p.2005-2012. (AMC) 1693. van Iterson M, Bervoets S, de Meijer EJ, Buermans HP, 't Hoen PAC, Menezes R, Boer JM. Integrated analysis of microRNA and mRNA expression: adding biological significance to microRNA target predictions. Nucleic Acids Res 2013; 41: e146. (VUmc) 1694. van Iterson M, van de Wiel M, Boer JM, Menezes R. General power and sample size calculations for high- dimensional genomic data. Stat Appl Genet Mol 2013; 12: 449-467. (VUmc) 1695. Van Keep MML, Huitema ADR, Schellens JHM, Beijnen JH. Eribulin: New oncolytic agent for the treatment of metastatic breast cancer. Pharm Weekbl 2013; 148:60-4 (NKI) 1696. Van Kerrebroeck P, Chapple C, Drogendijk T, Klaver M, Sokol R, Speakman M, Traudtner K, Drake MJ. Combination therapy with solifenacin and tamsulosin oral controlled absorption system in a single tablet for lower urinary tract symptoms in men: efficacy and safety results from the randomised controlled NEPTUNE trial. European Urology 64(6), 2013, p.1003-1012. (AMC) 1697. Van Kessel CS., Samim M, Koopman M, van den Bosch MAAJ, Borel Rinkes IHM, Punt CJA, van Hillegersberg R. Radiological heterogeneity in response to chemotherapy is associated with poor survival in patients with colorectal liver metastases. European Journal of Cancer 49(11), 2013, p.2486-2493. (AMC) 1698. van Kooijk Y, Kalay H, Garcia Vallejo JJ. Analytical Tools for the Study of Cellular Glycosylation in the Immune System. Frontiers in Immunology 2013; 2013: . (VUmc) 1699. van Kooijk Y, Unger WWJ, Fehres CM, Kalay H, Garcia Vallejo JJ. Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation. Mol Immunol 2013; 55: 143-145. (VUmc) 1700. Van Kranen S, Mencarelli A, van Beek S, Rasch C, van Herk M, Sonke J-J. Adaptive radiotherapy with an average anatomy model: evaluation and quantification of residual deformations in head and neck cancer patients. Radiotherapy and Oncology 109(3), 2013, p.463-468. (AMC/NKI) 1701. van Krieken JH, Normanno N, Blackhall F, Boone E, Botti G, Carneiro F, Celik I, Ciardiello F, Cree IA, Deans ZC, Edsjo A, Groenen PJTA, Kamarainen O, Kreipe HH, Ligtenberg MJL, Marchetti A, Murray S, Opdam FJM, Patterson SD, Patton S, Pinto C, Rouleau E, Schuuring E, Sterck S, Taron M, Tejpar S, Timens W, Thunnissen E, van de Ven PM, Siebers AG, Dequeker E. Guideline on the requirements of external quality assessment programs in molecular pathology. Virchows Arch 2013; 462: 27-37. (VUmc) 1702. Van Kuilenburg AB, Maring JG: Evaluation of 5-fluorouracil pharmacokinetic models and therapeutic drug monitoring in cancer patients. Pharmacogenomics 14(7), 2013, p.799-811. (AMC) 1703. Van Leersum NJ, Janssen-Heijnen MLG, Wouters MWJM, Rutten HJT, Coebergh JW, Tollenaar RAEM, Lemmens VEPP. Increasing prevalence of comorbidity in patients with colorectal cancer in the South of
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the Netherlands 1995-2010. Int J Cancer 2013; 132:2157-63 (NKI)
1704. van Leeuwen IJ, da Costa Pereira D, Flach KD, Piersma SR, Haase C, Bier D, Yalcin Z, Michalides R, Feenstra KA, Jimenez CR, de Greef TFA, Brunsveld L, Ottmann C, Zwart W, de Boer AH. Interaction of 14-3-3 proteins with the Estrogen Receptor Alpha F domain provides a drug target interface. P Natl Acad SCI USA 2013; 110: 8894-8899. (VUmc) 1705. van Leeuwen MA, du Pre MF, van Wanrooij RL, de Ruiter LF, Raatgeep HC, Lindenbergh-Kortleve DJ, Mulder CJ, de Ridder L, Escher JC, Samsom JN. Changes in Natural Foxp3(+)Treg but Not Mucosally- Imprinted CD62L(neg) CD38(+)Foxp3(+)Treg in the Circulation of Celiac Disease Patients. PLoS One 2013; 8: e68432. (VUmc) 1706. Van Leeuwen R, Schep-Akkerman A, van Laarhoven HWM. Screening Patient Spirituality and Spiritual Needs in Oncology Nursing. Holistic Nursing Practice 27(4), 2013, p.207-216. (AMC) 1707. Van Lent WAM, De Beer RD, van Triest B, Van Harten WH. Selecting indicators for international benchmarking of radiotherapy centres. J Radiother Pract 2013; 12:26-38 (NKI) 1708. Van Lienden KP, Hoekstra LT, Bennink RJ, van Gulik TM. Intrahepatic left to right portoportal venous collateral vascular formation in patients undergoing right portal vein ligation. Cardiovascular and Interventional Radiology 36(6), 2013, p.1572-1579. (AMC) 1709. Van Lienden KP, Hoekstra LT, van Trigt JD, Roelofs JJ, van Delden OM, van Gulik TM. Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2 tumor model. Hepatobiliary & Pancreatic Diseases International 12(6), 2013, p.622-629. (AMC) 1710. Van Lienden KP, van den Esschert JW, de Graaf W, Bipat S, Lameris JS, van Gulik TM, van Delden OM. Portal vein embolization before liver resection: a systematic review. Cardiovascular and Interventional Radiology 36(1), 2013, p.25-34. (AMC) 1711. van Litsenburg RRL, Huisman J, Raat H, Kaspers GJL, Gemke RJBJ. Health-related quality of life and utility scores in short-term survivors of pediatric acute lymphoblastic leukemia. Qual Life Res 2013; 22: 677-681. (VUmc) 1712. Van Loosdregt J, Fleskens V, Fu J, Brenkman A, Bekker C, Pals C, Meerding J, Berkers C, Barbi J, Grone A, Sijts A, Maurice M, Kalkhoven E, Prakken B, Ovaa H, Pan F, Zaiss D, Coffer P. Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity 2013; 39:259-71 (NKI) 1713. Van Luijt PA, Fracheboud J, Heijnsdijk EAM, den Heeten GJ, de Koning HJ. Nation-wide data on screening performance during the transition to digital mammography: observations in 6 million screens. European Journal of Cancer 49(16), 2013, p.3517-3525. 1714. Van Meurs HS, Bleeker MCG, van der Velden J, Overbeek LIH, Kenter GG, Buist MR. The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study. International Journal of Gynecologcial Cancer 23(8), 2013, p.1417-1422. (VUmc/AMC/NKI) 1715. Van Meurs HS, Tajik P, Hof MHP, Vergote I, Kenter GG, Mol BWJ, Buist MR., Bossuyt PM. Which patients benefit most from primary surgery or neoadjuvant chemotherapy in stage IIIC or IV ovarian cancer? An exploratory analysis of the European Organisation for Research and Treatment of Cancer 55971 randomised trial. European Journal of Cancer 49(15), 2013, p.3191-3201. (VUmc/AMC/NKI) 1716. Van Monsjou HS, Lopez-Yurda MI, Hauptmann M, van den Brekel MWM, Balm AJM, Wreesmann VB. Oral and oropharyngeal squamous cell carcinoma in young patients: the Netherlands Cancer Institute experience. Head and Neck Journal for the Sciences and Specialities of the Head and Neck 35(1), 2013, p.94-102. (AMC/NKI) 1717. Van Monsjou HS, Wreesmann VB, van den Brekel MWM, Balm AJM. Head and neck squamous cell carcinoma in young patients. Oral Oncology 49(12), 2013, p.1097-1102. (AMC/NKI) 1718. Van Muilekom E. How does ONS Congress help educate Dutch oncology nurses? ONS Connect 2013; 28:25 (NKI) 1719. Van Nes J, Chan A, van Groningen T, van Sluis P, Koster J, Versteeg R. A NOTCH3 transcriptional module induces cell motility in neuroblastoma. Clinical Cancer Research 19(13), 2013, p.3485-3494. (AMC) 1720. Van Nierop BJ, Coolen BF, Dijk WJR, Hendriks AD, de Graaf L, Nicolay K, Strijkers GJ. Quantitative first-pass perfusion MRI of the mouse myocardium. Magnetic Resonance in Medicine 69(6), 2013, p.1735-1744. (AMC) 1721. van Nieuwenhuizen D, Ambachtsheer N, Heimans JJ, Reijneveld JC, Peerdeman SM, Klein M. Neurocognitive functioning and health-related quality of life in patients with radiologically suspected meningiomas. J Neuro-Oncol 2013; 113: 433-440. (VUmc) 1722. Van Noesel Jan, Van der Ven WH, van Os TAM, Kunst PWA, Weegenaar J, Reinten RJA, Kancha RK, Duyster J, van Noesel CJM. Activating germline R776H mutation in the epidermal growth factor receptor associated with lung cancer with squamous differentiation. Journal of Clinical Oncology 31(10), 2013, p.e161-e164. (AMC) 1723. Van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JFWM, Tijssen JGP, Speelman P, Dijkgraaf MGW, Keller JJ. Duodenal infusion of donor feces for recurrent Clostridium difficile. New England Journal of Medicine 368(5), 2013, p.407-415. (AMC) 1724. Van Noorden CJF, Chieco P. Image cytometry protocols. Journal of Histochemistry & Cytochemistry
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61(10), 2013, p.759-760. (AMC) 1725. van Olst E, Vermeulen C, Menezes R, Howell M, Smit EF, van Beusechem VW. Affordable Luciferase Reporter Assay for Cell-Based High-Throughput Screening. J Biomol Screen 2013; 18: 453-461. (VUmc) 1726. Van Oorschot B, Hovingh SE, Rodermond H, Guclu A, Losekoot N, Geldof AA, Barendsen GW, Stalpers LJ, Franken NAP. Decay of gamma-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells. Oncol Rep 2013; 29: 2175-2180. (VUmc/AMC) 1727. van Oosten BW, Killestein J, Wattjes MP. Case Reports of PML in Patients Treated for Psoriasis Reply. New Engl J Med 2013; 369: 1081-1082. (VUmc) 1728. Van Oostveen CJ, Vermeulen H, Gouma DJ, Bakker PJ, Ubbink DT. Explaining the amount of care needed by hospitalised surgical patients: a prospective time and motion study. BMC Health Services Research 13(1), 2013, p.42-. (AMC) 1729. van Poelgeest MI, Welters MJ, van Esch EM, Stynenbosch LF, Kerpershoek G, van Persijn van Meerten EL, van den Hende M, Lowik MJ, Berends-van der Meer DM, Fathers LM, Valentijn AR, Oostendorp J, Fleuren GJ, Melief CJ, Kenter GG, van der Burg SH. HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial. Science Translat Med 2013; 11: 88. (VUmc) 1730. Van Ravesteijn VF, Boellaard TN, van der Paardt MP, Serlie IWO, de Haan MC, Stoker J, van Vliet LJ, Vos FM. Electronic cleansing for 24-h limited bowel preparation CT colonography using principal curvature flow. IEEE Transactions on Biomedical Engineering 60(11), 2013, p.3036-3045. (AMC) 1731. Van Rees Vellinga S, de la Rosette J. An update on the Clinical Research Office of the Endourology Society Team. Journal of Endourology 27(7), 2013, p.818-819. (AMC) 1732. van Rijen MML, Kluytmans v, Verkade EJM, ten Ham PBG, Feingold BJ, Kluijtmans JAJW. Lifestyle- Associated Risk Factors for Community-Acquired Methicillin-Resistant Staphylococcus aureus Carriage in the Netherlands: An Exploratory Hospital-Based Case-Control Study. PLoS One 2013; 8: e65594. (VUmc) 1733. van Rijn S, Nilsson J, Noske DP, Vandertop WP, Tannous BA, Wurdinger T. Functional multiplex reporter assay using tagged Gaussia luciferase. Sci Rep 2013; 3: 1046. (VUmc) 1734. Van Rooij N, van Buuren M, Philips D, Velds A, Toebes M, Heemskerk B, van Dijk L, Behjati S, Hilkmann H, El Atmioui D, Nieuwland M, Stratton M, Kerkhoven R, Kesmir C, Haanen J, Kvistborg P, Schumacher T. Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive Melanoma. J Clin Oncol 2013; 31(32):e439-42:e439-e442 (NKI) 1735. Van Roon AH, Goede SL, van Ballegooijen M, van Vuuren AJ, Looman CW, Biermann K, Reijerink JC, Mannetje H', van der Togt AC, Habbema JD, van Leerdam ME, Kuipers EJ. Random comparison of repeated faecal immunochemical testing at different intervals for population-based colorectal cancer screening. Gut 2013; 62:409-15 (NKI) 1736. Van Samkar G, Eshuis WJ, Lemmers M, Gouma DJ, Bennink Roel J, Hollmann MW, Dijkgraaf MGW, Busch ORC. Value of Scintigraphy for Assessing Delayed Gastric Emptying After Pancreatic Surgery. World Journal of Surgery 37(12), 2013, p.2911-2917. (AMC) 1737. van Schaik FDM, Mooiweer E, ten Have M, Belderbos TDG, Ten Kate FJW, Offerhaus GJA, Schipper MEI, Dijkstra G, Pierik M, Stokkers PCF, Ponsioen C, de Jong DJ, Hommes DW, van Bodegraven AA, Siersema PD, van Oijen MGH, Oldenburg B. Adenomas in Patients with Inflammatory Bowel Disease Are Associated with an Increased Risk of Advanced Neoplasia. Inflamm Bowel Dis 2013; 19: 342-349. (VUmc/AMC) 1738. van Thuijl HF, Ylstra B, Würdinger T, van Nieuwenhuizen D, Heimans JJ, Wesseling P, Reijneveld JC. Genetics and pharmacogenomics of diffuse gliomas. Pharmacol Therapeut 2013; 137: 78-88. (VUmc) 1739. van Tilborg AA, Nielsen K, Scheffer HJ, van den Tol P, van Waesberghe JHTM, Sietses C, Meijerink MR. Bipolar radiofrequency ablation for symptomatic giant (>10 cm) hepatic cavernous haemangiomas: initial clinical experience. Clin Radiol 2013; 68: e9-e14. (VUmc) 1740. van Trommel NE, Lok CAR, Suiten H, Thomas CMG, Massuger LFAG. Long-term Outcome of Placental Site Trophoblastic Tumor in the Netherlands. J Reprod Med 2013; 58: 224-228. (VUmc) 1741. van Tuyl LHD, Boers M. Patient-reported Remission in Rheumatoid Arthritis. J Rheumatol 2013; 40: 350- 352. (VUmc) 1742. van Velden FHP, Boellaard R. Reply to: Area under the cumulative SUV-volume histogram is not a viable metric of intratumoral metabolic heterogeneity. Eur J Nucl Med Mol I 2013; 40: 1469-1470. (VUmc) 1743. Van Vilsteren FGI, Alvarez Herrero L, Pouw RE, Schrijnders D, Sondermeijer CMT, Bisschops R, Esteban JM, Meining A, Neuhaus H, Parra-Blanco A, Pech O, Ragunath K, Rembacken B, Schenk BE, Visser M, ten Kate FJW, Meijer SL, Reitsma JB, Weusten BLAM, Schoon EJ, Bergman JJGHM. Predictive factors for initial treatment response after circumferential radiofrequency ablation for Barrett's esophagus with early neoplasia: a prospective multicenter study. Endoscopy 45(7), 2013, p.516-525. (AMC) 1744. Van Vilsteren FGI, Phoa KN, Alvarez Herrero L, Pouw RE, Sondermeijer CMT, van Lijnschoten I, Seldenrijk KA, Visser M, Meijer SL, van Berge Henegouwen MI, Weusten BLAM, Schoon EJ, Bergman JJGHM. Circumferential balloon-based radiofrequency ablation of Barrett's esophagus with dysplasia can be simplified, yet efficacy maintained, by omitting the cleaning phase. Clinical Gastroenterology and Hepatology 11(5), 2013, p.491-98.e1. (AMC) 1745. Van Vilsteren FGI, Phoa KN, Alvarez Herrero L, Pouw RE, Sondermeijer CMT, Visser M, ten Kate FJW, van Berge Henegouwen MI, Weusten BLAM, Schoon EJ, Bergman JJGHM. A simplified regimen for focal radiofrequency ablation of Barrett's mucosa: a randomized multicenter trial comparing two ablation regimens. Gastrointestinal Endoscopy 78(1), 2013, p.30-38. (AMC)
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