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Sleeve Gastrectomy Rapidly Enhances Islet Function Independently of Body Weight

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Sleeve Gastrectomy Rapidly Enhances Islet Function Independently of Body Weight Sleeve gastrectomy rapidly enhances islet function independently of body weight Jonathan D. Douros, … , Jonathan Campbell, David D’Alessio JCI Insight. 2019;4(6):e126688. https://doi.org/10.1172/jci.insight.126688. Research Article Endocrinology Metabolism Bariatric surgeries including vertical sleeve gastrectomy (VSG) ameliorate obesity and diabetes. Weight loss and accompanying increases to insulin sensitivity contribute to improved glycemia after surgery; however, studies in humans also suggest weight-independent actions of bariatric procedures to lower blood glucose, possibly by improving insulin secretion. To evaluate this hypothesis, we compared VSG-operated mice with pair-fed, sham-surgical controls (PF-Sham) 2 weeks after surgery. This paradigm yielded similar postoperative body weight and insulin sensitivity between VSG and calorically restricted PF-Sham animals. However, VSG improved glucose tolerance and markedly enhanced insulin secretion during oral nutrient and i.p. glucose challenges compared with controls. Islets from VSG mice displayed a unique transcriptional signature enriched for genes involved in Ca2+ signaling and insulin secretion pathways. This finding suggests that bariatric surgery leads to intrinsic changes within the islet that alter function. Indeed, islets isolated from VSG mice had increased glucose-stimulated insulin secretion and a left-shifted glucose sensitivity curve compared with islets from PF-Sham mice. Isolated islets from VSG animals showed corresponding increases in the pulse duration of glucose-stimulated Ca2+ oscillations. Together, these findings demonstrate a weight-independent improvement in glycemic control following VSG, which is, in part, driven by improved insulin secretion and associated with substantial changes in islet gene expression. These results support a model in which β cells play a key role in the adaptation […] Find the latest version: https://jci.me/126688/pdf RESEARCH ARTICLE Sleeve gastrectomy rapidly enhances islet function independently of body weight Jonathan D. Douros,1 Jingjing Niu,1 Sophia Sdao,2 Trillian Gregg,2 Kelsey Fisher-Wellman,1 Manish Bharadwaj,3 Anthony Molina,3 Ramamani Arumugam,1 MacKenzie Martin,1 Enrico Petretto,4 Matthew J. Merrins,2 Mark A. Herman,1 Jenny Tong,1 Jonathan Campbell,1 and David D’Alessio1 1Division of Endocrinology, Duke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA. 2Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, Wisconsin, USA. 3Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. 4Centre for Computational Biology, Duke-NUS Medical School, Singapore. Bariatric surgeries including vertical sleeve gastrectomy (VSG) ameliorate obesity and diabetes. Weight loss and accompanying increases to insulin sensitivity contribute to improved glycemia after surgery; however, studies in humans also suggest weight-independent actions of bariatric procedures to lower blood glucose, possibly by improving insulin secretion. To evaluate this hypothesis, we compared VSG-operated mice with pair-fed, sham-surgical controls (PF-Sham) 2 weeks after surgery. This paradigm yielded similar postoperative body weight and insulin sensitivity between VSG and calorically restricted PF-Sham animals. However, VSG improved glucose tolerance and markedly enhanced insulin secretion during oral nutrient and i.p. glucose challenges compared with controls. Islets from VSG mice displayed a unique transcriptional signature enriched for genes involved in Ca2+ signaling and insulin secretion pathways. This finding suggests that bariatric surgery leads to intrinsic changes within the islet that alter function. Indeed, islets isolated from VSG mice had increased glucose-stimulated insulin secretion and a left-shifted glucose sensitivity curve compared with islets from PF-Sham mice. Isolated islets from VSG animals showed corresponding increases in the pulse duration of glucose-stimulated Ca2+ oscillations. Together, these findings demonstrate a weight-independent improvement in glycemic control following VSG, which is, in part, driven by improved insulin secretion and associated with substantial changes in islet gene expression. These results support a model in which β cells play a key role in the adaptation to bariatric surgery and the improved glucose tolerance that is typical of these procedures. Introduction Bariatric surgery represents an effective treatment for weight loss and also has dramatic effects on diabetes, causing protracted remission in 40%–50% of affected patients (1, 2). There are a number of common surgical approaches, each of which makes distinctive modifications to the gastrointestinal anatomy and may play a role in improving glucose control. Vertical sleeve gastrectomy (VSG), now the most common Conflict of interest: The authors have bariatric procedure in the US (2), removes a large percentage of the body of the stomach, converting this declared that no conflict of interest distensible muscular organ into a tight sleeve. Roux-en Y gastric bypass (RYGB) reduces the stomach exists. to a small pouch that empties directly into the upper jejunum and diverts biliopancreatic secretions to Copyright: © 2019 American Society the distal small intestine. Adjustable gastric banding attaches an adjustable band to the proximal end for Clinical Investigation of the stomach, restricting entry of food to a small pouch. The RYGB and VSG dramatically increase Submitted: December 7, 2018 gastric-emptying rates (3–5), modify nutrient absorption (6–9), alter gastric emptying rates, and enhance Accepted: February 11, 2019 incretin secretion (10). All of these factors may play a role in the contemporaneous reductions in body Published: March 21, 2019 weight (BW) and insulin resistance, which contribute to improved glucose control (11–13) — particularly at later time points following surgery. However, numerous studies show that postsurgical improvements Reference information: JCI Insight. 2019;4(6):e126688. in glycemia occur prior to significant weight loss (14–16) and are superior to those seen in with weight https://doi.org/10.1172/jci. loss alone (16). Thus, the full complement of mechanisms responsible for improved glucose regulation insight.126688. after bariatric surgery remain unknown, despite intensive investigation (17, 18). insight.jci.org https://doi.org/10.1172/jci.insight.126688 1 RESEARCH ARTICLE In the first weeks to months following surgery, patients with diabetes demonstrate some restoration of the acute insulin response to intravenous (i.v.) glucose (19–21), the loss of which is a hallmark feature of diabetic islet dysfunction (22). The early return of the acute insulin response is weight independent and is not directly dependent on insulinotropic factors from the surgically modified gut since theβ cell stimulus is given i.v. This observation suggests that bariatric surgery enhances islet function in a manner that does not require acute input from neuroendocrine sources. The studies described herein test the hypothesis that VSG improves glucose tol- erance by enhancing insulin secretion. In these studies, we compare mice with VSG to pair-fed, sham-surgical controls (PF-Sham) to assess insulin secretion in vivo and ex vivo independently of changes in body weight, insulin demand, or caloric balance. Results Preoperative metabolic parameters in high-fat diet–fed mice. Presurgical BW for a representative cohort of mice on high-fat diet (HFD; Research Diets, catalog D12451, 45% kcal from lipid; n = 15) over 8 weeks did not differ between animals before either VSG or sham surgery (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.126688DS1). Animals achieved a preoperative BW of 36.5 ± 1.07 g, with ~31% of the weight gain occurring in the last week before surgery. We speculate that this may be due to the Ensure meal transition 2 days before surgery or to accumulated metabolic stress during HFD exposure. Neither glucose excursion nor circulating insulin concentrations differed between groups allocated to VSG or Sham surgery during preoperative i.p. glucose tolerance tests (IPGTTs) or mixed-meal tolerance tests (MMTTs; Supplemental Figure 1, B–E). In vivo insulin secretion is enhanced by VSG during enteral nutrient delivery. A schematic of the experimental paradigm employed is shown in Figure 1A. During the first 2 weeks following surgery, both groups lost ~18% BW (7.46 ± 0.62 g; Figure 1B). BW and blood glucose during insulin tolerance tests (shown as per- centage of baseline glucose; Figure 1C) did not differ between groups, indicating comparable insulin sensi- tivity between the 2 groups. However, 6-hour fasting blood glucose was significantly decreased in the VSG group by ~13% (19 mg/dl; Figure 1D). Blood glucose during the MMTT peaked higher in VSG animals than controls 10 minutes following Ensure gavage, with a more rapid decline to baseline levels within 30 minutes (Figure 1E). While the glycemic profile differed in the controls, the integrated glucose AUC after Ensure gavage was similar between groups (Figure 1E). Fasting levels of insulin were similar in VSG and PF-Sham mice, but the postprandial rise was significantly greater in the VSG group 10 minutes after meal administration (Figure 1F). Plasma GLP-1 and GIP and were also elevated in the VSG group at 10 min- utes, while glucagon was increased at 0 and 10 minutes (Figure 1, G–I).
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