Spring 2019 a Scandalously Short History of MBB at Yale William C
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Paracelsus, Helmont, Iatrochemistry, Pharmacology
Basic Sciences of Medicine 2014, 3(3): 60-62 DOI: 10.5923/j.medicine.20140303.03 Paracelsus, the Founder of Chemical Therapeutic Who Initiated the Application of Chemistry to Life Hosein Tajadod Hafiz, an International Journal of Iranian studies, Tehran, Iran Abstract Paracelsus, a German-Swiss physician, alchemist, philosopher, and astrologer who denounced the Galenic system of medicine. The application of chemistry to life was initiated by him. In fact, he stressed the spiritual side of disease but also advocated the use of mineral as drugs, rather than just using plants and animal products. He burned the works of Avicenna, and quarreled with most of his colleagues at Basel and was dismissed in disgrace and resumed his wandering from place to place, teaching chemical therapy (iatrochemistry). Johannes Baptiste van Helmont, Flemish physician was the leading iatrochemist of seventeenth century, but he opposed the dogma of Galen, astrology of Paracelsus and many other established doctrines. Keywords Paracelsus, Helmont, Iatrochemistry, Pharmacology In the Renaissance some Europeans reacted against the 1. Paracelsus, the Creator of anatomy and other medical teachings expounded in medieval Iatrochemistry Islamic text, particularly the “Canon of Medicine” (al-Quanon fil-Tib), written by Avicenna (980-1037), a Iatrochemistry , the study of chemical phenomena in order famous and influential Iranian physician and to obtain results of medical value was founded by Paracelsus. philosopher-scientist. Leonardo da Vinci (1452-1519), Iatrochemists the followers of Paracelsus treated the Italian and the greatest artist and scientist of the Renaissance human body as a chemical system. In iatrochemistry, disease who studied the skeletal movement and muscle structures in was associated with upsets of body chemistry and treatment relation to function, rejected the anatomy, though by was directed toward restoration of the chemical balance. -
Wise Traditions
NUTRIENT-DENSE FOODS TRADITIONAL FATS LACTO-FERMENTATION BROTH IS BEAUTIFUL Wise $12 US THE WESTON A. PRICE FOUNDatION® Traditions THERAPIES NURTURING PARENTING PREPARED FARMING NON-TOXIC LABELING IN TRUTH ALERT! SOY for WiseTraditions Non Profit Org. IN FOOD, FARMING AND THE HEALING ARTS U.S. Postage Education Research Activism PAID #106-380 4200 WISCONSIN AVENUE, NW Suburban, MD Wise WASHINGTON, DC 20016 Permit 4889 Traditions IN FOOD, FARMING AND THE HEALING ARTS Volume 16 Number 1 Spring 2015 Spring 2015 ® HE ESTON RICE OUNDatION T W A. P F for WiseTraditions IN FOOD, FARMING AND THE HEALING ARTS Education Research Activism Volume NUTRIENT DENSE FOODS TRADITIONAL FATS LACTO-FERMENTATION BROTH IS BEAUTIFUL A CAMPAIGN FOR REAL MILK TRUTH IN LABELING 16 PREPARED PARENTING SOY ALERT! LIFE-GIVING WATER Number Cleansing Myths and Dangers Toxicity and Chronic Illness Gentle Detoxification NON-TOXIC FARMING PASTURE-FED LIVESTOCK NURTURING THERAPIES Great Nutrition Pioneers COMMUNITY SUPPORTED AGRICULTURE 1 The Fats on MyPlate Cooking with Blood A PUBLICatION OF THE WESTON A. PRICE FOUNDatION® You teach, you teach, you teach! Education Research Activism Last words of Dr. Weston A. Price, January 23, 1948 www.westonaprice.org COMMUNITY SUPPORTED AGRICULTURE LIFE-GIVING LIVESTOCK WATER FOR REAL MILK PASTURE-FED A CAMPAIGN Printed on Recycled Offset Printed with soy ink - an appropriate use of soy TECHNOLOGY AS SERVANT SCIENCE AS COUNSELOR KNOWLEDGE AS GUIDE 150123_cover.indd 1 3/24/15 7:07 AM WiseTraditions THE WESTON A. PRICE Upcoming Events IN FOOD, FARMING AND THE HEALING ARTS ® Volume16 Number 1 FOUNDatION Spring 2015 Education Research Activism 2015 EDITORS Sally Fallon Morell, MA The Weston A. -
Role of Vitamin a Status and Its Catabolism in the Regulation of Glucose and Lipid Homeostasis in Rats Under Physiological and Disease Conditions
University of Tennessee, Knoxville TRACE: Tennessee Research and Creative Exchange Doctoral Dissertations Graduate School 12-2014 Role of vitamin A status and its catabolism in the regulation of glucose and lipid homeostasis in rats under physiological and disease conditions Yang Li University of Tennessee - Knoxville, [email protected] Follow this and additional works at: https://trace.tennessee.edu/utk_graddiss Part of the Molecular, Genetic, and Biochemical Nutrition Commons Recommended Citation Li, Yang, "Role of vitamin A status and its catabolism in the regulation of glucose and lipid homeostasis in rats under physiological and disease conditions. " PhD diss., University of Tennessee, 2014. https://trace.tennessee.edu/utk_graddiss/3150 This Dissertation is brought to you for free and open access by the Graduate School at TRACE: Tennessee Research and Creative Exchange. It has been accepted for inclusion in Doctoral Dissertations by an authorized administrator of TRACE: Tennessee Research and Creative Exchange. For more information, please contact [email protected]. To the Graduate Council: I am submitting herewith a dissertation written by Yang Li entitled "Role of vitamin A status and its catabolism in the regulation of glucose and lipid homeostasis in rats under physiological and disease conditions." I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the equirr ements for the degree of Doctor of Philosophy, with a major in Nutritional Sciences. Guoxun Chen, Major Professor We have read this dissertation and recommend its acceptance: Jay Whelan, Ling Zhao, Michael Karlstad Accepted for the Council: Carolyn R. -
4:30 P. M. Thursday 16 April 1936 Yaleuniversity We Are Gathered
MEMORIAL EXERCISES IN HONOR OF LAFAYETTE BENEDICT MENDEL Sterling Professor of Physiological Chemistry Born 5 February 1872 Died 9 December 1935 Speakers PRESIDENT JAMES ROWLAND ANGELL, Presiding RUSSELL HENRY CHITTENDEN FREDERIC COLLIN WALCOTT PHOEBUS AARON LEVENE 4:30 P. M. Thursday 16 April 1936 Strathcona Hall Yale University We are gathered here to pay our tribute of admiration and respect to Lafayette Benedict Mendel, who died on December 9th last. During his long years of faithful service in this University, he endeared himself to hundreds of students who owe to him the inspiration of intellectual leadership and the severe discipline given by a learned and accurate scholar. His striking accomplishments in a relatively new field put him early in the front rank of American scientists and his entire career reflected lustre upon his Alma Mater, whom he served so devotedly. We are fortunate in having here to refresh our memories of our friend, Dr. Russell Henry Chittenden, Director-emeritus of the Sheffield Scientific School, who was Dr. Mendel's first teacher and for many years his colleague; the Honorable Frederic C. Walcott, YALE JOURNAL OF BIOLOGY AND MEDICINE, VOL. 8, NO. 6 560 YALE JOURNAL OF BIOLOGY AND MEDICINE formerly member of the United States Senate and now Commis- sioner of Welfare in Connecticut, who was a classmate; and Dr. Phoebus A. Levene of the Rockefeller Institute for Medical Research, for many years an intimate friend. Forty-five years ago there appeared in my laboratory a young man desirous of beginning the study of physiological chemistry. He came with a letter of introduction from the then Dean of Yale College, Henry P. -
Unit 8 – Alchemy and Chemistry in the Renaissance
Unit 8 – Alchemy and Chemistry in the Renaissance Sapienza University of Rome, Italy This work is licensed under a Creative Commons Attribution - Non-commercial 4.0 International The Roots of Chemistry and alchemy FEW SCIENTIFIC DISCIPLINES DEFINED THE COMPLEXITY OF THE RENAISSANCE AS MUCH AS ALCHEMY, AN AREA WHERE PHILOSOPHY, SCIENCE, OCCULTISM AND THEOLOGY CAME TOGETHER. ALCHEMY, A GENUINE PROTOSCIENCE?, DISPLAYED THE TRANSFORMATION FROM THEORETICAL DOGMA TO THE OBSERVATION AND PRACTICE BASED METHODS THAT GRADUALLY DEVELOPED DURING THIS PERIOD OF THE HISTORY OF SCIENCE This work is licensed under a Creative Commons 2 Attribution - Non-commercial 4.0 International The charm of alchemy The mysterious, occult side of alchemy still captures the imagination of the modern public, with Harry Potter chasing the elusive Philosopher’s Stone and names such as John Dee spawning thousands of occult sites studying the esoteric symbolism behind alchemical symbols Most of the modern interpretations have a basis in historical fact, and writers such as Chaucer, Ben Jonson, and Dante gleefully included alchemists as shady charlatans and figures of parody This work is licensed under a Creative Commons 3 Attribution - Non-commercial 4.0 International The reinaissance alchemist However, this comedic touch should not detract from the idea that Renaissance alchemists were often bona fide scientists, searching for truth and often applying the scientific method to their research In fact, it can be argued that, in terms of the development of science, the alchemists -
IOWNER of PROPERTY NAME Trumbull Associates, Mr
Form No. 10-300 (Rev. 10-74) UN1TI-D SI A IKS UhPART MHTWOF THt. INTERIOR. FOR NFS USE ONLY NATIONAL PARK SERVICE NATIONAL REGISTER OF HISTORIC PLACES RECEIVED INVENTORY « NOMINATION FORM DATE ENTERED SEE INSTRUCTIONS IN HOWTO COMPLETE NATIONAL REGISTER FORMS ____________TYPE ALL ENTRIES - COMPLETE APPLICABLE SECTIONS______ NAME HISTORIC Lafayette B. Mendel House AND/OR COMMON 18 Trumbull Street [LOCATION STREET & NUMBER 18 Trumbull Street —NOT FOR PUBLICATION CITY, TOWN CONGRESSIONAL DISTRICT New Haven — VICINITY OF 3rd STATE CODE COUNTY CODE Connecticut 09 New Haven 009 UCLASSIFICATION CATEGORY OWNERSHIP STATUS PRESENTUSE -^DISTRICT —PUBLIC X-OCCUPIED —AGRICULTURE —MUSEUM X-BUILDING(S) ^PRIVATE —UNOCCUPIED XX_cOMMERCIAL — PARK —STRUCTURE —BOTH —WORK IN PROGRESS —EDUCATIONAL —PRIVATE RESIDENCE —SITE PUBLIC ACQUISITION ACCESSIBLE —ENTERTAINMENT — RELIGIOUS —OBJECT —IN PROCESS KXYES: RESTRICTED —GOVERNMENT -.-SCIENTIFIC _ -BEING CONSIDERED _YES UNRESTRICTED ^.INDUSTRIAL —TRANSPORTATION _NO —MILITARY —OTHER IOWNER OF PROPERTY NAME Trumbull Associates, Mr. Geoffrey A. Hecht (6/20/78) Eighteen -Trumtrolrlr -Street -InGQgpcreat&d r -Me ^ -Enank -Movar-o ,. -PrestdeHt STREET & NUMBER 18 Trumbull Street CITY. TOWN STATE New Haven VICINITY OF Connecticut LOCATION OF LEGAL DESCRIPTION COURTHOUSE, REGISTRY OF DEEDS, ETC Q£ STREETS NUMBER . Orange Street CITY, TOWN STATE New Haven Connecticut REPRESENTATION IN EXISTING SURVEYS TITLE None DATE — FEDERAL -STATE __COUNTY .. .LOCAL DEPOSITORY FOR SURVEY RECORDS CITY, TOWN DESCRIPTION CONDITION CHECK ONE CHECK ONE ^EXCELLENT —DETERIORATED XX UNALTERED ^ORIGINAL SITE _GOOD Restored —RUINS —ALTERED —MOVED DATE. -FA1R xT~Unrestored -UNEXPOSED DESCRIBE THE PRESENT AND ORIGINAL (IF KNOWN) PHYSICAL APPEARANCE Eighteen Trumbull Street, the Lafayette B. Mendel House, is located in New Haven, Connecticut. The house is a two-and-one-half story brick building. -
“FOOD, YOUR FRIEND OR FOE” an Inaugural Lecture
UNIVERSITY OF PORT HARCOURT “FOOD, YOUR FRIEND OR FOE” An Inaugural Lecture By Professor (Mrs) Joyce Oronne Akaninwor BSc. MSc. (UNIBEN), PhD (UNIPORT), FHNR Department of Biochemistry, Faculty of Science INAUGURAL LECTURE SERIES NO. 131 28TH April, 2016. i DEDICATION I dedicate this inaugural lecture to: The Almighty, Omnipresent and Omniscient God. My Parents, Late Ven. S. Y. Chukuigwe (Rtd) and Matron I. C. Chukuigwe (Rtd). My darling husband, Late Sir N.N. Akaninwor, loving children: Buduka, Chinwe, Habinuchi, Manuchimso, Akpenuchi and grandchild, Maxwell Manuchimso Ndy Wenenda. ii ACKNOWLEDGEMENT Vice Chancellor Sir, permit me to appreciate and acknowledge those that made this day of my academic outing possible. First, I acknowledge my darling, amiable and charming husband, Late Sir N.N. Akaninwor for the privilege and support he gave me to work and study at the same time, irrespective of certain deprivations he must have experienced due to useful time I spent on academic work at the expense of family chores. My thanks go to my beloved children, Buduka, Chinwe, Habinuchi, Manuchimso and Akpenuchi who have always been my succour in times of tribulations as I was bearing and nurturing them alongside my studies and work; a task that was not very easy for all of us in all ramifications. My tribute goes to my Parents, Late Ven. S. Y. Chukuigwe (Rtd) and Matron I. C. Chukuigwe (Rtd) who made sure I was educated even when a girl-child education was not of priority, as well as my aunt, Chief (Dame) Eunice Igwe and her late husband, Sir I. Elechi Igwe, who nurtured me to what I am prior to my marriage; they were all indeed, my role models. -
User:Smallman12q/Articles/Chemistry 1 User:Smallman12q/Articles/Chemistry
User:Smallman12q/articles/Chemistry 1 User:Smallman12q/articles/Chemistry Chemistry (from Egyptian kēme (chem), meaning "earth"[1] ) is the science concerned with the composition, structure, and properties of matter, as well as the changes it undergoes during chemical reactions.[2] It is a physical science for studies of various atoms, molecules, crystals and other aggregates of matter whether in isolation or combination, which incorporates the concepts of energy and entropy in relation to the spontaneity of chemical processes. Modern chemistry evolved out of alchemy following the chemical revolution (1773). Disciplines within chemistry are traditionally grouped by the type of matter being studied or the kind of study. These include inorganic chemistry, the study of inorganic matter; organic chemistry, the study Chemistry is the science concerned with the composition, structure, and properties of matter, of organic matter; biochemistry, the study of substances found in as well as the changes it undergoes during biological organisms; physical chemistry, the energy related studies of chemical reactions. chemical systems at macro, molecular and submolecular scales; analytical chemistry, the analysis of material samples to gain an understanding of their chemical composition and structure. Many more specialized disciplines have emerged in recent years, e.g. neurochemistry the chemical study of the nervous system (see subdisciplines). Summary Chemistry is the scientific study of interaction of chemical [3] substances that are constituted of -
Retinoid Signaling Is a Context-Dependent Regulator of Embryonic Stem Cells
3 Retinoid Signaling is a Context-Dependent Regulator of Embryonic Stem Cells Zoltan Simandi and Laszlo Nagy University of Debrecen Hungary 1. Introduction Although the beneficial effect of certain foods, such as liver, egg or carrot is known from ancient remedies, one of the common active substances, called Vitamin A, was not identified until 1913, when it has been independently discovered by Elmer McCollum at the University of Wisconsin–Madison, and Lafayette Mendel and Thomas Burr Osborne at Yale University. Since then numerous studies have come to light documenting the effect of vitamin A on the health of the individual from birth to adult age. Hale has demonstrated among the first that deprivation of vitamin A during pregnancy induces congenital ocular malformation (Hale, 1933). Wilson and Warkany later described several other congenital malformations that occurred in fetuses from vitamin A-deficient (VAD) rats affecting the genito-urinary tract, heart and great vessels, ocular and respiratory system (Wilson and Warkany 1947; Wilson and Warkany 1950; Warkany 1954). In 1968 Saunders and Gasseling have shown that grafting a posterior margin zone (called zone of polarizing activity, ZPA) of a chick embryo limb bud to the anterior side is able to induce an extra set of limb structures (Saunders 1968). It suggested that the ZPA region contains a diffusible morphogen. Surprisingly, retinoic acid (RA), a derivative of vitamin A, has been found to have the same effect on the anterior side of the bud (Tickle, Alberts et al. 1982). There was a doubt that retinoic acid is responsible in vivo for the phenomenon, but in 1987 Thaller and Eichele demonstrated the graded distribution of endogenous retinoic acid from posterior to anterior in the limb bud (Thaller and Eichele 1987). -
Drug Discovery: a History
________________________________________________________________________________________________________________________ ______________________________ Drug Discovery A History Walter Sneader School of Pharmacy University of Strathclyde, Glasgow, UK ________________________________________________________________________________________________________________________ ______________________________ Drug Discovery ________________________________________________________________________________________________________________________ ______________________________ Drug Discovery A History Walter Sneader School of Pharmacy University of Strathclyde, Glasgow, UK Copyright u 2005 John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex PO19 8SQ, England Telephone (+44) 1243 779777 Email (for orders and customer service enquiries): [email protected] All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except under the terms of the Copyright, Designs and Patents Act 1988 or under the terms of a licence issued by the Copyright Licensing Agency Ltd, 90 Tottenham Court Road, London W1T 4LP, UK, without the permission in writing of the Publisher. Requests to the Publisher should be addressed to the Permissions Department, John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex PO19 8SQ, England, or emailed to [email protected], or faxed to (+44) 1243 -
Drug Discovery
DRUG DISCOVERY Edited by Hany A. El-Shemy Drug Discovery http://dx.doi.org/10.5772/3388 Edited by Hany A. El-Shemy Contributors Melanie A. Jordan, Lourdes Rodriguez-Fragoso, Irina Piatkov, Elizabeth Hong-Geller, Sonia Lobo-Planey, Pawel Kafarski, Gluza Karolina, Malemud, Jolanta Natalia Latosińska, Magdalena Latosińska, Terry Smith, Luis Jesús Villarreal- Gómez, Irma E. Soria-Mercado, Ana Leticia Iglesias, Graciela Lizeth Perez-Gonzalez, Carsten Wrenger, Eva Liebau, Taosheng Chen, Asli Nur Goktug, Sergio C. Chai, Xin Liang, Jimmy Cui, Jonathan Low, Henning Ulrich, Claudiana Lameu, Gabriel Magoma, Samuel Constant, Christophe Mas, Song Huang, Ludovic Wiszniewski Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2013 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. -
The Vitamin a Story Lifting the Shadow of Death the Vitamin a Story – Lifting the Shadow of Death World Review of Nutrition and Dietetics
World Review of Nutrition and Dietetics Editor: B. Koletzko Vol. 104 R.D. Semba The Vitamin A Story Lifting the Shadow of Death The Vitamin A Story – Lifting the Shadow of Death World Review of Nutrition and Dietetics Vol. 104 Series Editor Berthold Koletzko Dr. von Hauner Children’s Hospital, Ludwig-Maximilians University of Munich, Munich, Germany Richard D. Semba The Vitamin A Story Lifting the Shadow of Death 41 figures, 2 in color and 9 tables, 2012 Basel · Freiburg · Paris · London · New York · New Delhi · Bangkok · Beijing · Tokyo · Kuala Lumpur · Singapore · Sydney Dr. Richard D. Semba The Johns Hopkins University School of Medicine Baltimore, Md., USA Library of Congress Cataloging-in-Publication Data Semba, Richard D. The vitamin A story : lifting the shadow of death / Richard D. Semba. p. ; cm. -- (World review of nutrition and dietetics, ISSN 0084-2230 ; v. 104) Includes bibliographical references and index. ISBN 978-3-318-02188-2 (hard cover : alk. paper) -- ISBN 978-3-318-02189-9 (e-ISBN) I. Title. II. Series: World review of nutrition and dietetics ; v. 104. 0084-2230 [DNLM: 1. Vitamin A Deficiency--history. 2. History, 19th Century. 3. Night Blindness--history. 4. Vitamin A--therapeutic use. W1 WO898 v.104 2012 / WD 110] 613.2'86--dc23 2012022410 Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents® and PubMed/MEDLINE. Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety.