17 Complications in Thyroid and Parathyroid Surgery
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217 17 Complications in Thyroid and Parathyroid Surgery Andrea Frilling and Frank Weber Contents Once death from thyroid operation became an exception, specific pitfalls of the procedure, namely, 17.1 Introduction . 217 injuries to the laryngeal nerves and damage to the 17.2 General Complications . 217 parathyroid glands, became obvious. While some sur- 17.3 General Surgical Complications . 218 geons, including Kocher, tried to prevent recurrent 17.3.1 Wound Infection . 218 laryngeal nerve injuries by avoiding any contact with 17.3.2 Edema . 218 the region of the nerve, others advocated routine iden- 17.3.3 Bleeding . 218 tification and dissection of the nerve. The importance 17.3.4 Malpositioning . 218 17.4 Specific Surgical Complications . 218 of the external branch of the superior laryngeal nerve 17.4.1 Unilateral Injury to the Recurrent was not appreciated until decades later. Halsted is Laryngeal Nerve . 218 credited for his studies of surgical anatomy and blood 17.4.2 Bilateral Recurrent supply of the parathyroid glands and the introduction Laryngeal Nerve Injury . 220 of the technique of capsular dissection that imple- 17.4.3 Injury to the Superior Laryngeal Nerve . 221 mented preservation of the vascular pedicle of a para- 17.4.4 Rare Neural, Vascular, thyroid gland and led to a safer approach to thyroid and Visceral Lesions . 221 and parathyroid surgery. Today morbidity remains a 17.4.5 Tracheal Instability . 222 subject of concern for surgeons performing thyroid 17.4.6 Injury to the Lymphatic Structures . 222 and parathyroid procedures. Injury of the recurrent 17.4.7 Hypoparathyroidism . 222 laryngeal nerve and hypoparathyroidism are the most 17.4.8 Thyroid Storm . 223 frequent complications. The key issue of an effective References . 223 and safe surgical approach is a profound knowledge of specific anatomy and pathophysiology in combina- tion with meticulous handling and dissection of tis- sue. The overall permanent complication rate should 17.1 Introduction not exceed 1% in centers providing expertise [2–4]. The relationship between volume of operations and Mortality from thyroid and parathyroid surgery is outcome has been extensively examined by Sosa et virtually disregarded nowadays. During the eigh- al. in the State of Maryland [2]. They demonstrated teenth century, however, the mortality rate of thyroid a significant inverse relationship between the volume surgery was as high as 40% from bleeding and sepsis of thyroidectomies performed by individual surgeons [1]. As a consequence, in 1850 the French Academy and complication rates, postoperative length of stay, of Medicine recommended its routine use be aban- and hospital charges. Surgeons who performed more doned, and many leading surgeons would not per- than 100 thyroidectomies over a 6-year period had form it. The greatest advance in thyroid surgery is to the lowest hospital charges, compared with those per- be credited to Theodor Kocher who first recognized forming 30–100 cases, 10–29 cases, and between one the importance of anti- and aseptic handling, hemo- and nine cases. stasis, and precise operative technique. Within a de- cade, his overall operative mortality decreased from 15% to 2.4%. With the exclusion of complicated cases, 17.2 General Complications in 1898 he reported a mortality rate of only 0.18%. Following Kocher’s principles, William Halsted, Endocrine neck surgery is associated with general Charles Mayo, George Crile, and others contributed non-surgical morbidity in less than 1.5% of patients, further to the development of thyroid surgery. corresponding to respiratory (1.5%), urologic (0.9%), 218 Andrea Frilling and Frank Weber gastrointestinal (0.8%), and cardiac (0.5%) complica- sels, can be performed prior to wound closure. Rou- tions. In addition, allergy, drug, or other abnormal tine use of suction drains does not prevent postopera- reactions are reported in 0.4% of patients [2]. tive cervical bleeding. In the majority of patients, symptomatic hemor- rhage occurs between 6 and 12 hours after the initial 17.3 General Surgical Complications operation. Since in approximately 20% of cases the onset of hematoma symptoms is reported beyond 17.3.1 Wound Infection 24 hours postoperatively, ambulatory surgery with a 4- to 8-hour observation period might harbor risk Wound infections, usually caused by Staphylococ- of delayed intervention [7]. Once recognized, the cus or Streptococcus species are considered to be rare wound should be deliberately reopened and the he- events, occurring in 0.3% [5] to 0.8% [2] of cases. matoma evacuated. In case of significant respiratory Antibiotic prophylaxis is recommended only in im- distress emergency bedside hematoma evacuation, if munocompromised patients or in those with val- necessary in combination with endotracheal intuba- vular cardiac disorders. While mild neck cellulitis tion, is required. The requirement for tracheotomy frequently regresses under conservative treatment, either in the emergency setting or due to persisting abscesses require rapid incision and evacuation. De- airway obstruction after hematoma removal is gener- lay of invasive treatment can result in devastating me- ally a rare event. diastinitis. Clinically evident seromas respond well to percutaneous aspiration. 17.3.4 Malpositioning 17.3.2 Edema The brachial plexus and ulnar nerve may be at risk when a patient is malpositioned on the operating Laryngotracheal edema can be a cause of respiratory table. In order to avoid nerve paralysis both arms obstruction after extensive thyroid surgery. After bi- should be adducted and secured. Hyperextension of lateral lymphadenectomy, disturbances of lymphatic the head causes nausea and headache during the early flow may be the cause of edema. Pharyngolaryngeal postoperative course. edema, in addition, is a well-recognized complication caused by the endotracheal tube or laryngeal mask and can also occur in association with an anaphy- 17.4 Specific Surgical Complications lactoid reaction [6]. Steroid therapy, occasionally in combination with temporary reintubation, leads to 17.4.1 Unilateral Injury to the Recurrent rapid relief. Laryngeal Nerve Recurrent laryngeal nerve (RLN) injury is one of the 17.3.3 Bleeding most serious complications in endocrine surgery. It is related to significant morbidity and frequent mal- The incidence of symptomatic hemorrhage requir- practice litigation [10]. The recurrent laryngeal nerve ing reintervention amounts to 0.1–1.5% [5–9]. Post- originates from the trunk of the vagus nerve. Upon operative bleeding will characteristically be prefaced reaching the larynx, it is renamed the inferior laryn- by respiratory distress, pain, or cervical pressure, geal nerve. It innervates all the intrinsic muscles of dysphagia, and increased blood drainage. No specific the same side with the exception of the cricothyroid perioperative risk factors that would allow identifica- muscles, and supplies sensory innervation to the la- tion of the high-risk patient population for this po- ryngeal mucosa below the true vocal folds. While as- tentially lethal complication are known. High surgical cending, the nerve on the right and on the left side volume does not reduce the incidence of hematoma delivers branches that supply the trachea and the formation. Consequently, the key issue of prevention esophagus. The morphologic appearance and course is attention to anatomic detail and careful hemosta- of the recurrent laryngeal nerve are subject to great sis during surgery. If the surgeon is uncertain about anatomic variability. In addition, it may often be over- the dryness of the operative field, a Valsalva maneu- looked that the nerve most frequently does not con- ver, which elevates the intrapulmonary pressure to sist only of a single trunk but exhibits a network of 40 cm H20 and facilitates recognition of bleeding ves- smaller branches. On the right side it usually loops 17 Complications in Thyroid and Parathyroid Surgery 219 around and behind the subclavian artery and then as- the posterior thyroid capsule near the cricoid cartilage cends into the neck in the tracheoesophageal groove and upper tracheal rings. In addition to visual identi- to enter the larynx distal to the inferior cornu of the fication, the nerve can be located by direct palpation thyroid cartilage. In instances of embryologic malfor- of the tracheal wall below the lower thyroid pole. mation of the aortic arch in terms of retroesophageal Considerable debate has long existed concerning the right subclavian artery, the nerve passes with a more necessity of deliberate exposure of the recurrent la- median course directly to the larynx (non-recurrent ryngeal nerve during thyroid surgery. Kocher com- laryngeal nerve) (Fig. 7.4). Although the reported in- mented on postoperative hoarseness and stated that, cidence of non-recurrent laryngeal nerve is less than following his technique of thyroid dissection, injury 1%, the surgeon has to be aware of the existence of to the nerve can with certainty be avoided without this rare anatomic condition [11,12]. The left recur- the direct exposure. The first surgeon who advocated rent laryngeal nerve courses upward around the liga- routine dissection and demonstration of the nerves in mentum arteriosum and the aortic arch and runs 1911 was August Bier of Berlin; he was followed by vertically toward the tracheoesophageal groove. On Frank Lahey of Boston in 1938 [13]. Others advocated their way to the cricothyroid muscle where they en- that exposure itself is a risk due to potential induction ter the larynx, both nerves run close to the capsule of local edema by dissection of adjacent tissues and of the lateral aspect of the thyroid and cross the infe- hemorrhage. Following these initial experiences, sev- rior thyroid artery. Several variations of the relation- eral studies revealed that depending upon the skill of ship between the nerve and the artery, particularly an individual surgeon principal identification of the on the right side, can be observed. The nerve may nerve reduces the risk of permanent laryngeal nerve pass superficially to the artery, deep to it, or between injuries from over 5% to less than 1% (Table 17.1) the branches of the vessel (Fig.