International Journal of Molecular Sciences Review Molecular Changes Underlying Hypertrophic Scarring Following Burns Involve Specific Deregulations at All Wound Healing Stages (Inflammation, Proliferation and Maturation) Matúš Comaˇ 1,2, Lucia Fröhlichová 3, Lukáš Urban 1,4, Robert Zajíˇcek 5, Tomáš Urban 5, Pavol Szabo 6,7 , Štˇepán Novák 6,8, Vitaly Fetissov 5, Barbora Dvoˇránková 6,7, Karel Smetana Jr. 6,7,* and Peter Gál 1,4,5,* 1 Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc., 040 11 Košice, Slovakia;
[email protected] (M.C.);ˇ
[email protected] (L.U.) 2 Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia 3 Department of Pathology, Louise Pasteur University Hospital, 041 90 Košice, Slovakia;
[email protected] 4 Center of Clinical and Preclinical Research MediPark, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia 5 Prague Burn Centre, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, 100 34 Prague, Czech Republic;
[email protected] (R.Z.);
[email protected] (T.U.);
[email protected] (V.F.) 6 Institute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic;
[email protected] (P.S.);
[email protected] (Š.N.);
[email protected] (B.D.) 7 BIOCEV, 252 50 Vestec, Czech Republic 8 Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, 150 06 Prague, Czech Republic * Correspondence:
[email protected] (K.S.J.);
[email protected] (P.G.); Fax: +421-55-789-1613 (P.G.) Citation: Coma,ˇ M.; Fröhlichová, L.; Urban, L.; Zajíˇcek,R.; Urban, T.; Abstract: Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results Szabo, P.; Novák, Š.; Fetissov, V.; in progressive deterioration of the structure and function of organs.