Skin Sensitisation Prediction Using in Vitro Screening Methods
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University of Groningen Formaldehyde-Releasers In
University of Groningen Formaldehyde-releasers in cosmetics de Groot, Anton C.; White, Ian R.; Flyvholm, Mari-Ann; Lensen, Gerda; Coenraads, Pieter- Jan Published in: CONTACT DERMATITIS IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2010 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): de Groot, A. C., White, I. R., Flyvholm, M-A., Lensen, G., & Coenraads, P-J. (2010). Formaldehyde- releasers in cosmetics: relationship to formaldehyde contact allergy Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics. CONTACT DERMATITIS, 62(1), 18-31. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license. More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne- amendment. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. -
Safety Assessment of Imidazolidinyl Urea As Used in Cosmetics
Safety Assessment of Imidazolidinyl Urea as Used in Cosmetics Status: Re-Review for Panel Review Release Date: May 10, 2019 Panel Meeting Date: June 6-7, 2019 The 2019 Cosmetic Ingredient Review Expert Panel members are: Chair, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Ronald A. Hill, Ph.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; James G. Marks, Jr., M.D., Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Executive Director is Bart Heldreth, Ph.D. This safety assessment was prepared by Christina L. Burnett, Senior Scientific Analyst/Writer. © Cosmetic Ingredient Review 1620 L Street, NW, Suite 1200 ♢ Washington, DC 20036-4702 ♢ ph 202.331.0651 ♢ fax 202.331.0088 ♢ [email protected] Distributed for Comment Only -- Do Not Cite or Quote Commitment & Credibility since 1976 Memorandum To: CIR Expert Panel Members and Liaisons From: Christina Burnett, Senior Scientific Writer/Analyst Date: May 10, 2019 Subject: Re-Review of the Safety Assessment of Imidazolidinyl Urea Imidazolidinyl Urea was one of the first ingredients reviewed by the CIR Expert Panel, and the final safety assessment was published in 1980 with the conclusion “safe when incorporated in cosmetic products in amounts similar to those presently marketed” (imurea062019origrep). In 2001, after considering new studies and updated use data, the Panel determined to not re-open the safety assessment (imurea062019RR1sum). The minutes from the Panel deliberations of that re-review are included (imurea062019min_RR1). Minutes from the deliberations of the original review are unavailable. -
United States Patent (19) 11 Patent Number: 5,854,246 Francois Et Al
USOO5854246A United States Patent (19) 11 Patent Number: 5,854,246 Francois et al. (45) Date of Patent: Dec. 29, 1998 54 TOPICAL KETOCONAZOLE EMULSIONS 52 U.S. Cl. .......................... 514/252; 514/852; 514/881; 252/106; 252/172; 252/174.11; 252/544; 75 Inventors: Marc Karel Jozef Francois, 252/547; 252/551; 252/555; 252/399 Kalmthout; Eric Carolus Leonarda 58 Field of Search ..................................... 252/106, 173, Snoeckx, Beerse, both of Belgium 252/124.11, 124.23, 544, 547, 551, 555, 399; 514/257, 852, 881 73 Assignee: Janssen Pharmaceutica, N.V., Beerse, Belgium 56) References Cited U.S. PATENT DOCUMENTS 21 Appl. No.: 793,359 4,335,125 6/1982 Heeres et al. ........................... 424/250 22 PCT Filed: Aug. 25, 1995 4.942,162 7/1990 Rosenberg et al. ..................... 514/252 86 PCT No.: PCT/EP95/03366 4,976,953 12/1990 Orr et al. ........ ... 424/47 5,002,974 3/1991 Geria .............. ... 514/782 S371 Date: Feb. 24, 1997 5,215,839 6/1993 Kamishita et al ... 424/45 5,456,851 10/1995 Lin et al. ................................ 252/106 S 102(e) Date: Feb. 24, 1997 Primary Examiner Keith D. MacMillan 87 PCT Pub. No.: WO96/06613 Attorney, Agent, or Firm Mary Appollina 57 ABSTRACT PCT Pub. Date: Mar. 7, 1996 The invention concerns Stable emulsions comprising keto 30 Foreign Application Priority Data conazole having a pH in the range from 6 to 8, characterized Sep. 1, 1994 EP European Pat. Off. ............ 942O2SOS in that the emulsions lack Sodium Sulfite as an antioxidant; process of preparing Said emulsions. -
Formaldehyde and Formaldehyde Releasers
INVESTIGATION REPORT FORMALDEHYDE AND FORMALDEHYDE RELEASERS SUBSTANCE NAME: Formaldehyde IUPAC NAME: Methanal EC NUMBER: 200-001-8 CAS NUMBER: 50-00-0 SUBSTANCE NAME(S): - IUPAC NAME(S): - EC NUMBER(S): - CAS NUMBER(S):- CONTACT DETAILS OF THE DOSSIER SUBMITTER: EUROPEAN CHEMICALS AGENCY Annankatu 18, P.O. Box 400, 00121 Helsinki, Finland tel: +358-9-686180 www.echa.europa DATE: 15 March 2017 CONTENTS INVESTIGATION REPORT – FORMALDEHYDE AND FORMALDEHYDE RELEASERS ................ 1 1. Summary.............................................................................................................. 1 2. Report .................................................................................................................. 2 2.1. Background ........................................................................................................ 2 3. Approach .............................................................................................................. 4 3.1. Task 1: Co-operation with FR and NL ..................................................................... 4 3.2. Task 2: Formaldehyde releasers ........................................................................... 4 4. Results of investigation ........................................................................................... 6 4.1. Formaldehyde..................................................................................................... 6 4.2. Information on formaldehyde releasing substances and their uses ............................ 6 4.2.1. -
Imidazolidinyl Urea
Imidazolidinyl urea 39236-46-9 OVERVIEW This material was prepared for the National Cancer Institute (NCI) for consideration by the Chemical Selection Working Group (CSWG) by Technical Resources International, Inc. under contract no. N02-07007. Imidazolidinyl urea came to the attention of the NCI Division of Cancer Biology (DCB) as the result of a class study on formaldehyde releasers. Used in combination with parabens, imidazolidinyl urea is one of the most widely used preservative systems in the world and is commonly found in cosmetics. Based on a lack of information in the available literature on the carcinogenicity and genetic toxicology, DCB forwarded imidazolidinyl urea to the NCI Short-Term Toxicity Program (STTP) for mutagenicity testing. Based on the results from the STTP, further toxicity testing of imidazolidinyl urea may be warranted. INPUT FROM GOVERNMENT AGENCIES/INDUSTRY Dr. John Walker, Executive Director of the TSCA Interagency Testing Committee (ITC), provided information on the production volumes for this chemical. Dr. Harold Seifried of the NCI provided mutagenicity data from the STTP. NOMINATION OF IMIDAZOLIDINYL UREA TO THE NTP Based on a review of available relevant literature and the recommendations of the Chemical Selection Working Group (CSWG) held on December 17, 2003, NCI nominates this chemical for testing by the National Toxicology Program (NTP) and forwards the following information: • The attached Summary of Data for Chemical Selection • Copies of references cited in the Summary of Data for Chemical Selection • CSWG recommendations to: (1) Evaluate the chemical for genetic toxicology in greater depth than the existing data, (2) Evaluate the disposition of the chemical in rodents, specifically for dermal absorption, (3) Expand the review of the information to include an evaluation of possible break- down products, especially diazolidinyl urea and formaldehyde. -
Diazolidinyl Urea
Diazolidinyl urea sc-234554 Material Safety Data Sheet Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Diazolidinyl urea STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY1 HEALTH2 HAZARD INSTABILITY0 SUPPLIER Company: Santa Cruz Biotechnology, Inc. Address: 2145 Delaware Ave Santa Cruz, CA 95060 Telephone: 800.457.3801 or 831.457.3800 Emergency Tel: CHEMWATCH: From within the US and Canada: 877-715-9305 Emergency Tel: From outside the US and Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 PRODUCT USE Preservative; laboratory reagent. SYNONYMS C8-H14-N4-O7, "Germall II", "Germall II", diazolidinylurea, "urea, N-[1, 3-bis(hydroxymethyl)-2, 5-dioxo-4-imidazolidinyl]-", "urea, N-[1, 3-bis(hydroxymethyl)-2, 5-dioxo-4-imidazolidinyl]-", "N, N' -bis(hydroxymethyl)-", "N, N' -bis(hydroxymethyl)-", "N-(1, 3-bis(hydroxymethyl)-2, 5-dioxo-4-midazolidinyl)-", "N-(1, 3-bis(hydroxymethyl)-2, 5-dioxo-4-midazolidinyl)-", "N, N' -bis(hydroxymethyl)urea", "N, N' -bis(hydroxymethyl)urea", "Unidiacide U26", "N-(hydroxymethyl)-N-(1, 3-dihydroxymethyl-2, 5-dioxo-4-imidazolidinyl)-", "N-(hydroxymethyl)-N-(1, 3-dihydroxymethyl-2, 5-dioxo-4-imidazolidinyl)-", "N' -(hydroxymethyl)urea", "N' -(hydroxymethyl)urea", "imidazolidinyl urea 11", "Germaben II", "Germaben II", "Integra 22" Section 2 - HAZARDS IDENTIFICATION CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK 1 of 16 May cause SENSITIZATION by skin contact. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED • Accidental ingestion of the material may be damaging to the health of the individual. EYE • There is some evidence that material may produce eye irritation in some persons and produce eye damage 24 hours or more after instillation. -
Cosmetic Compositions with Tricyclodecane Amides Kosmetische Zusammensetzungen Mit Trizyklodekanamiden Composition Cosmétique Contenant Les Amides De Tricyclododecane
(19) TZZ Z _T (11) EP 2 969 026 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 8/34 (2006.01) A61K 8/06 (2006.01) 01.11.2017 Bulletin 2017/44 A61K 8/365 (2006.01) A61Q 17/04 (2006.01) C07D 211/16 (2006.01) C07D 307/22 (2006.01) (2006.01) (2006.01) (21) Application number: 14708585.6 C07D 217/06 C07D 215/08 C07C 233/58 (2006.01) C07D 211/66 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) (22) Date of filing: 10.03.2014 C07D 205/04 (2006.01) C07D 207/06 (2006.01) A61K 8/04 (2006.01) A61K 8/368 (2006.01) A61K 8/42 (2006.01) A61K 8/37 (2006.01) A61K 8/49 (2006.01) A61K 8/63 (2006.01) A61Q 19/00 (2006.01) (86) International application number: PCT/EP2014/054604 (87) International publication number: WO 2014/139963 (18.09.2014 Gazette 2014/38) (54) COSMETIC COMPOSITIONS WITH TRICYCLODECANE AMIDES KOSMETISCHE ZUSAMMENSETZUNGEN MIT TRIZYKLODEKANAMIDEN COMPOSITION COSMÉTIQUE CONTENANT LES AMIDES DE TRICYCLODODECANE (84) Designated Contracting States: • CLOUDSDALE, Ian Stuart AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Chapel Hill, North Carolina 27516 (US) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO • AU, Van PL PT RO RS SE SI SK SM TR Trumbull, Connecticut 06611 (US) • LEE, Jianming (30) Priority: 13.03.2013 US 201361778831 P Trumbull, Connecticut 06611 (US) • DICKSON, JR, John Kenneth (43) Date of publication of application: Apex, North Carolina 27523 (US) 20.01.2016 Bulletin 2016/03 (74) Representative: Corsten, Michael Allan (73) Proprietors: Unilever N.V.