MicroRNA Regulation of Molecular Networks Mapped by Global MicroRNA, mRNA, and Protein Expression in Activated T Lymphocytes This information is current as of September 27, 2021. Yevgeniy A. Grigoryev, Sunil M. Kurian, Traver Hart, Aleksey A. Nakorchevsky, Caifu Chen, Daniel Campbell, Steven R. Head, John R. Yates III and Daniel R. Salomon J Immunol 2011; 187:2233-2243; Prepublished online 25 July 2011; Downloaded from doi: 10.4049/jimmunol.1101233 http://www.jimmunol.org/content/187/5/2233 http://www.jimmunol.org/ Supplementary http://www.jimmunol.org/content/suppl/2011/07/25/jimmunol.110123 Material 3.DC1 References This article cites 83 articles, 31 of which you can access for free at: http://www.jimmunol.org/content/187/5/2233.full#ref-list-1

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The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2011 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology

MicroRNA Regulation of Molecular Networks Mapped by Global MicroRNA, mRNA, and Protein Expression in Activated T Lymphocytes

Yevgeniy A. Grigoryev,* Sunil M. Kurian,* Traver Hart,* Aleksey A. Nakorchevsky,† Caifu Chen,‡ Daniel Campbell,x Steven R. Head,x John R. Yates, III,† and Daniel R. Salomon*

MicroRNAs (miRNAs) regulate specific immune mechanisms, but their genome-wide regulation of T lymphocyte activation is largely unknown. We performed a multidimensional functional genomics analysis to integrate genome-wide differential mRNA, miRNA, and protein expression as a function of human T lymphocyte activation and time. We surveyed expression of 420 human miRNAs in parallel with genome-wide mRNA expression. We identified a unique signature of 71 differentially expressed miRNAs, Downloaded from 57 of which were previously not known as regulators of immune activation. The majority of miRNAs are upregulated, mRNA expression of these target genes is downregulated, and this is a function of binding multiple miRNAs (combinatorial targeting). Our data reveal that consideration of this complex signature, rather than single miRNAs, is necessary to construct a full picture of miRNA-mediated regulation. Molecular network mapping of miRNA targets revealed the regulation of activation-induced immune signaling. In contrast, pathways populated by genes that are not miRNA targets are enriched for metabolism and biosynthesis. Finally, we specifically validated miR-155 (known) and miR-221 (novel in T lymphocytes) using locked nucleic acid inhibitors. http://www.jimmunol.org/ Inhibition of these two highly upregulated miRNAs in CD4+ T cells was shown to increase proliferation by removing suppression of four target genes linked to proliferation and survival. Thus, multiple lines of evidence link top functional networks directly to T lymphocyte immunity, underlining the value of mapping global gene, protein, and miRNA expression. The Journal of Immu- nology, 2011, 187: 2233–2243.

lymphocytes regulate the adaptive immune response by coordinated fashion to achieve a balance among proliferation, serving as Ag-specific effector cells. Activation via TCR memory, and quiescence. T engagement and CD28 costimulation is characterized by MicroRNAs (miRNAs) have emerged as posttranscriptional by guest on September 27, 2021 gene upregulation (1) and is a highly regulated process requiring regulators of gene expression in a variety of biological processes coordination of multiple signaling pathways for proliferation, cyto- (3–7). The mode of miRNA regulation is protein repression via kines, and differentiation. After Ag clearance, some effector cells complementary sequence recognition in the 39 untranslated region must be reduced or eliminated by mechanisms like activation- of the target mRNA and/or degradation of the target transcript (8– induced cell death (2). Thus, activation must be regulated in a 11). A recent paper indicates the major effect of miRNAs is to decrease mRNA levels (12). miRNAs can potentially regulate hundreds of proteins (13) and *Department of Molecular and Experimental Medicine, The Scripps Research In- modulate concentration of proteins over a narrow range in a dose- † stitute, La Jolla, CA 92037; Department of Chemical Physiology, The Scripps Re- dependent manner (14, 15). miRNAs are involved in hematopoi- search Institute, La Jolla, CA 92037; ‡Applied Biosystems, Foster City, CA 94404; and xDNA Microarray Core, The Scripps Research Institute, La Jolla, CA 92037 etic cell function and development (as summarized in Refs. 16– Received for publication May 2, 2011. Accepted for publication June 17, 2011. 64). A few miRNAs have been linked to specific T lymphocyte This work was supported by National Institutes of Health Grants U19 A1063603 and mechanisms—181a (37), 181c (39), 155 (28), 150 (18), 146 (20), R01 AI081757. and 142 (40)—via regulation of T cell sensitivity to Ag stimula- Y.A.G., S.M.K., and D.R.S. conceived and designed the experiments and wrote the tion, regulating transcription factors, and activation-induced cell manuscript; Y.A.G., S.M.K., and A.A.N. performed the experiments; Y.A.G., A.A.N., death. However, at the global level, little is known about the im- and T.H. analyzed the data; and C.C., D.C., S.R.H., and J.R.Y. contributed reagents/ materials/analysis tools. pact of activation-induced miRNAs on mRNA and protein ex- pression in human T lymphocytes, particularly in the context of The sequences presented in this article (entire set of CEL files) have been submitted to the National Center for Biotechnology Information Gene Expression Omnibus mapping miRNA-regulated molecular networks. under accession number GSE14352 (http://www.ncbi.nlm.nih.gov/geo/query/acc. In this study, we show that differentially upregulated miRNAs cgi?acc=GSE14352). regulate T lymphocyte activation by targeting highly differentially Address correspondence and reprint requests to Dr. Daniel R. Salomon, Department expressed genes involved in networks critical for cell activation, of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, Mail Code MEM-L55, La Jolla, CA 92037. E-mail address: proliferation, and survival. We used a multidimensional approach [email protected] to integrate genome-wide miRNA, mRNA, and protein expression. The online version of this article contains supplemental material. We surveyed expression for 420 human miRNA sequences at 0, 24,

Abbreviations used in this article: Ct, threshold cycle; FDR, false discovery rate; IPA, 48, and 72 h after activation. In parallel, we profiled global mRNA Ingenuity Pathways Analysis; LNA, locked nucleic acid; miRNA, microRNA; qPCR, and protein expression. We found 71 significantly differentially ex- quantitative real-time PCR. pressed miRNAs, of which 57 have not been previously linked to Copyright Ó 2011 by The American Association of Immunologists, Inc. 0022-1767/11/$16.00 T lymphocyte function. Testing several established miRNA target www.jimmunol.org/cgi/doi/10.4049/jimmunol.1101233 2234 microRNA-REGULATED NETWORKS IN T CELL ACTIVATION prediction algorithms, we demonstrated globally that targets of performed for specified pairwise comparisons among all time points of multiple upregulated miRNAs (combinatorial targeting) have de- activation. creased mRNA expression with activation. In validation, we In parallel, we performed our own analysis of differential gene ex- pression to corroborate AltAnalyze results. CEL files for each donor from showed that inhibition of two highly upregulated miRNAs in the 1.0ST HuEx Arrays were normalized by robust multiarray averaging CD4+ T cells increased proliferation by removing suppression of using a custom cumulative distribution function downloaded from the four target genes involved in proliferation and survival. Thus, University of Michigan (http://brainarray.mbni.med.umich.edu/Brainarray/ our studies provide novel evidence for a large number of func- Database/CustomCDF/genomic_curated_CDF.asp). Differential expression was measured with the Limma package (http://www.bioconductor.org/ tional molecular networks populated by downregulated targets of packages/2.6/bioc/html/limma.html) using a two-class model. All calcu- highly upregulated miRNAs. lations were performed in R/Bioconductor. Genes were filtered using a fold-change filter of 1.5 (0.58 in log2) and an FDR filter of 0.01. Genes that were detected as significantly differentially expressed by both AltA- Materials and Methods nalyze and Limma analysis were then selected for further analysis. T lymphocyte isolation The Multidimensional Protein Identification Tool proteomics Blood draw for this study was accepted by our institution’s ethical com- mission, and all subjects gave their written consent according to review The Multidimensional Protein Identification Tool (66) protocol was used board guidelines. CD2+ T lymphocytes were purified from Ficoll-Hypaque as described previously (1). Protein fraction was denatured, alkylated, and density-separated PBMCs of seven healthy human donors. MACS CD2+ trypsin digested. A total of 50 mg digested protein sample at 0 and 48 h micromagnetic beads were used for the positive isolation of CD2+ T cells was run in four technical replicates. Data were acquired using an LTQ LX using an MACS separator with LS columns (Miltenyi Biotec). CD4+ linear ion trap mass spectrometer (Thermo Fisher Scientific) interfaced in- T lymphocytes were isolated from PBMCs of three human blood donors by line with two-dimensional HPLC in a data-dependent manner in which Downloaded from negative selection with the MACS CD4+ T Cell Negative Isolation Kit II each analytical full scan (mass spectrometry; range 200–2000 mass-to- (Miltenyi Biotec) according to the manufacturer’s protocol. charge ratio units) was followed by three fragmentation scans (tandem mass spectrometry) that targeted the three most abundant ions from the full Lymphocyte activation, RNA, and protein isolation scan. The 40-microsecond collision-induced dissociation pulses of 35% intensity were used for precursor ion fragmentation. A default exclusion Freshly isolated CD2+ T lymphocytes were resuspended in RPMI 1640 list (Xcalibur 2.0; Thermo Fisher Scientific) of 180-s, 50 precursor ion medium (HyClone) supplemented with 10% (v/v) FBS and 2 mM gluta- members was used for data acquisition. Raw data were searched against mine, with penicillin (100 U/ml) and streptomycin (100 U/ml), and acti- the European Bioinformatics Institute database (12/01/2006 release) sup- http://www.jimmunol.org/ vated with CD3/CD28 Dynal beads (Invitrogen) according to the manu- plemented with a decoy database in which each entry of the original pro- facturer’s protocol. Cell activation was confirmed by flow cytometry for tein contains its reversed sequence. Database searching used SEQUEST the following activation markers: CD134 (OX40), CD150 (SLAM), CD25 (v27), and outcomes were filtered using DTASelect version 2.0. Protein (IL-2Ra), CD69, and CD71 (transferrin receptor); and intracellular cyto- identifications were extracted, and a measure of normalized amino acid kines: IFN-g, IL-10, IL-2, IL-4, and TNF-a for activated T cells as shown coverage was used as label-free quantification. Relative quantifications previously (1). The cells were harvested and stabilized in RNALater were done using spectral counts normalized to the median of the total (Ambion) at 0, 24, 48, and 72 h postactivation. Total RNA was extracted spectral counts. Protein identifications across replicate experiments were using the mirVana miRNA Isolation Kit (Ambion), which also allows for pooled to represent a union for each category of 0 and 48 h postactivation. the isolation of the total proteome fraction. Proteins identified in two or more technical replicates per category were kept for further analysis. Relative protein abundance was compared be- miRNA profiling by guest on September 27, 2021 tween the 0- and 48-h postactivation for proteins present in more than one TaqMan stem-loop RT-PCR method (65) was performed on an ABI category. Proteins identified in more than one technical replicate in a single 7900HT Real-Time PCR system (Applied Biosystems) for 420 human category and not in any category were also considered for functional miRNA primer/probes on 0.5 mg total RNA from 0-, 24-, 48-, and 72-h analysis as unique identifications. A two-tailed Student t test was used for CD2+ T lymphocyte samples. A two-tailed Student t test with a p value hypothesis testing, and the significant differentially expressed proteins threshold of 0.05 and false discovery rate (FDR)-adjusted p value (q-value) (p , 0.05) were considered for functional analysis. threshold of 0.1, for which q-value = p value 3 number tested/rank, be- tween 0 and 48 h was used on the normalized data to identify differentially miRNA target analysis expressed miRNAs. A q-value of 0.1 implies that 10% of significant tests For prediction of target genes of differentially expressed miRNAs, three will result in false positives. miRNA expression following locked nucleic publicly available algorithms were used: PITA, MiRanda, and TargetScan acid (LNA) nucleoporation in CD4+ T cells was measured with TaqMan 5.1. In the end, TargetScan predictions based on conservation scores were MicroRNA Assays (Applied Biosystems) for hsa-miR-155 and -221 in used to compute the 50th percentile targets in our expressed gene set. accordance with manufacturers’ protocols. U6 was used as an internal control. Functional mapping Microarray profiling We used Ingenuity Pathways Analysis (IPA; https://analysis.ingenuity.com) to map molecular pathways and networks populated by predicted miRNA A total of 1.5 mg total RNA per sample was converted into labeled cDNA targets. The IPA Database is a constantly curated resource of published using the GeneChip WT Sense Target Labeling kit (Affymetrix). Labeled literature on gene functions and interactions. Canonical pathway and net- cDNA was hybridized to Affymetrix Human Exon 1.0 ST arrays (Affy- works analysis was carried out by uploading the predicted downregulated metrix). Data for mRNA transcript profiles were generated in the form of genes targeted by the upregulated miRNAs. Significance of association CEL files using standard protocols. between genes and pathway was measured by the Benjamini and Hochberg Microarray data multiple testing corrected p value that can be interpreted as an upper bound for the expected fraction of falsely rejected null hypotheses among all Data have been deposited in the Gene Expression Omnibus under accession functions with p values smaller than the threshold of 0.05. Network node number GSE14352 and can be viewed at http://www.ncbi.nlm.nih.gov/geo/ genes were based on an especially high degree of links to other genes in query/acc.cgi?acc=GSE14352. the IPA database. Differential gene expression analysis Electroporation Raw data expression values from CEL files were normalized by robust A total of 3 3 106 primary human CD4+ T lymphocytes were electro- multiarray averaging algorithm provided through Affymetrix Power Tools porated in Nucleofector II instrument (Amaxa) using the Human T cell (Affymetrix) and summarized in AltAnalyze software (http://altanalyze. Nucleofector kit (VPA-1002; Lonza) in duplicate with 50 nM miRCURY org), retaining only probesets that align to a single Ensembl gene. Gene- LNA microRNA Power Inhibitor or scrambled negative control probes expression values were calculated based on the mean expression of all core (Exiqon) against hsa-miR-221 and -155 according to the manufacturer’s probesets detected above background (p value thresholds for p , 0.01; protocol. After electroporation, cells were cultured in RPMI 1640 medium FDR 0.01). Fold changes and p value (two-tailed t test assuming unequal supplemented with 10% (v/v) FBS and 2 mM glutamine, and after 2 h, half variance) were calculated for each time point comparison. Statistics were of the medium was replaced with fresh medium. At 24 h after electro- The Journal of Immunology 2235 poration, the cells were activated with CD3/CD28 Dynal beads (Invitrogen) Based on current literature, of these 71 differentially expressed for 48 h. miRNAs, only 14 have a documented function in T lymphocytes: Cell proliferation assay miR-150 (18, 19), miR-155 (18, 25), miR-181a (37), miR-106a (31, 33), the miR-17–92 cluster (30, 32), miR-24 (6, 47), miR-21 Cell proliferation was measured using the Ziva Cell Proliferation Assay (18, 53), miR-223 (41), and miR-let-7f (18) (Tables I, II). Five (Jaden BioScience). Electroporated CD4+ T lymphocytes were plated at 8 3 104/well in 96-well plates in duplicate for each condition and activated additional miRNAs are linked to development or aberrant activation for 48 h with CD3/CD28 beads. Cells were pulsed with 10 mM BrdU/well of hematopoietic cells (Supplemental Table I). For example, our 18 h before harvesting. Forty-eight hours after activation, cells were har- results indicate that miR-150 is downregulated in T cells upon 4 vested, expander beads removed, and 10 cells/well were plated in 96-well activation, consistent with studies in murine lymphocytes (19). In Thermo Scientific Nunc Plates (Fisher). Cell proliferation was measured contrast, miR-155 is upregulated in activated human and murine with a chemiluminescent substrate to detect the presence of an anti-BrdU Ab labeled with alkaline phosphatase on the Insight-Mi Luminometer T lymphocytes (26). Importantly, we identified 57 differentially (Jaden BioScience). The signal was fully developed and measured 60 min expressed miRNAs currently undocumented in T lymphocyte after the addition of the substrate. activation. Quantitative RT-PCR Predicted targets of differentially upregulated miRNAs are globally downregulated A total of 300 ng total RNA from CD4+ T cells was transcribed into cDNA using qScript cDNA Supermix (Quanta Biosiences) according to the manu- Starting with the 71 differentially expressed miRNAs, we mapped facturer’s guidelines, and gene expression for IRS2, IKBKE, FOS, and the gene targets of the 51 differentially upregulated. Predictive PIK3R1 was quantitated with PrimeTime qPCR assays (Integrated DNA

algorithms rely on multiple parameters: seed complementarity, Downloaded from Technologies) using PerfeCta qPCR FastMix kit (Quanta Biosiences) on the ABI 7900HT Fast Real-Time PCR instrument (Applied Biosystems). thermodynamics, and biochemical properties of binding and Expression of 18S gene was set as endogenous control. For data analysis, evolutionary conservation. Unfortunately, these algorithms suffer the threshold cycle (Ct) (67) value was determined and specific gene ex- from high false-positive and -negative rates. Combining predictions pression normalized to endogenous control using d-d threshold cycle (Ct) from different algorithms may be useful, but there is little overlap in method. The normalized d C from LNA-transfected samples was then t top targets predicted by different algorithms (70, 71). We tested compared with the scrambled control to obtain d-d Ct values and used to calculate relative fold change compared with control. Experiments were 50th percentile predictions for these 51 differentially upregulated http://www.jimmunol.org/ performed in triplicate. The primer probe sequences for validation assays miRNAs using four algorithms: PITA (72), MiRanda (73), and were as follows: IKBKE Probe (0.5 nM), 59-/56-FAM/TAC CTG ATC TargetScan5.1 context or conservation scores (74). We measured 9 /ZEN/CCG GCT CTT CAC CA/3IABkFQ/-3 ; IKBKE Primer1 (1 nM), the change (d) in mRNA expression between 0 and 48 h for all 59-CAT CTT GTC CAA ACA GCA CTG-39; IKBKE Primer2 (1 nM): 59- AAA ATATCA CGG AGA CCC AGG-39; FOS Probe (0.5 nM), 59-/56- genes above background (expression $6.5; log2 scale). We then FAM/TGC AGA CCG /ZEN/AGATTG CCA ACCT/3IABkFQ/-39; FOS plotted differences in distribution of deltas between predicted Primer1 (1 nM), 59-CAT CAG GGATCT TGC AGG C-39; FOS Primer2 (1 targets and nontargets. MiRanda failed to produce any expression nM), 59-GACTGA TAC ACT CCA AGC GG-39; IRS2 Probe (0.5 nM), 59-/ correlations with our data and was not used further. Predictions 56-FAM/AGG CCA CCA /ZEN/TCG TGA AAG AGT GAA G/ 3IABkFQ/-39; IRS2 Primer1 (1 nM), 59-TGA CAT CCT GGT GAT AAA with TargetScan and PITA based on testing the effects of single

GCC-39; IRS2 Primer2 (1 nM), 59-ACT TCT TGT CCC ACC ACT TG-39; miRNA binding also revealed no shift in mRNA signals with by guest on September 27, 2021 PIK3R1 Probe (0.5 nM), 59-/56-FAM/CAC AAT GCT /ZEN/TTA CTT activation. In contrast, plotting the gene expression of targets CGC CGT CCA C/3IABkFQ/-39; PIK3R1 Primer1 (1 nM), 59-CTG TAC predicted to bind multiple upregulated miRNAs (e.g., $4or$7) AAGTTATAG GGCTCG G-39; and PIK3R1 Primer2 (1 nM), 59-GAT revealed that combinatorial miRNA binding decreases mRNA GGC ACT TTT CTT GTC CG-39. expression (Fig. 1C,1D). Combinatorial targeting benchmarked at Statistics the 50th percentile with both PITA and TargetScan gave the best All statistical analyses used the Student t test of at least three independent predictions (Fig. 1E–J). As shown in Fig. 1I and 1J, TargetScan experiments, unless stated otherwise. Differences with p values ,0.05 are conservation predictions with combinatorial binding of four or considered significant. more miRNAs show the best results correlating increased miRNA binding with decreased target gene expression. Results T lymphocyte activation is marked by global gene upregulation Activated T lymphocytes demonstrate a unique including miRNA-processing machinery activation-induced miRNA signature We showed previously that T lymphocyte activation is dominated We used a multidimensional approach to integrate genome-wide by widespread differential gene upregulation (1). We therefore miRNA, mRNA, and protein expression (Fig. 1A). We activated analyzed differential gene expression in parallel with miRNA human T lymphocytes via CD3/CD28 costimulation and harvested expression. Genome-wide mRNA transcript analysis revealed cells at 0, 24, 48, and 72 h. This activation strategy modeled al- 3798 differentially expressed mRNA transcripts between 0 and logeneic activation (68, 69). We surveyed miRNA expression 48 h (p , 0.01; FDR 1%): 3362 upregulated (89%) and 436 using quantitative real-time PCR (qPCR) for 420 human miRNA downregulated. Upregulation of the miRNA processing/biogenesis sequences. Specific miRNAs were differentially expressed in genes included: XPO5, EIF2C2/AGO2, SIP1/GEMIN2, -4, -5, -6, T lymphocytes as a function of activation. We identified 71 dif- and -7, RANGAP1, YBX1, and ADARB1 (Table III). ferentially expressed miRNAs (p , 0.05; q , 0.1) between 0 and 48 h, of which 51 were upregulated (Table I). We chose 48 h as a Predicted targets of upregulated miRNAs populate networks key time point in T lymphocyte activation based on peak cell associated with immunity, cell survival, and proliferation proliferation, cytokine production, and expression of activation Using TargetScan conservation predictions, we identified 1640 markers (1). These changes in miRNA expression are robust candidate miRNA targets, of which 214 were downregulated across all donors (Fig. 1B). The top 12 upregulated miRNAs were (Supplemental Table II). Thus, half of all 436 downregulated genes miR-221, -210, -98, -29b, -155, -218, -455-3p, -449, -548d, -222, are targets of upregulated miRNAs. Functional pathway and net- -132, and -18a. The top downregulated miRNAs were miR-181a, work enrichment analysis was done for the 182 out of 214 -223, -224, -150, -146b, -126, -127-3p, -376a, -100, -99a, -125b, downregulated targets that mapped to known functional pathways and -26a (Table II). and the 200 that mapped to molecular networks. 2236 microRNA-REGULATED NETWORKS IN T CELL ACTIVATION Downloaded from http://www.jimmunol.org/ by guest on September 27, 2021

FIGURE 1. Combinatorial targeting by multiple upregulated miRNAs during T cell activation demonstrates decreased mRNA levels after activation with increased miRNA binding. A, Schematic of our experimental approach. B, miRNA signature of T cell activation: heat map of 71 statistically significant (p , 0.05; q , 0.1), differentially expressed miRNAs at 0 and 48 h. Heat map shows expression at 0, 24, 48, and 72 h across seven donors. Red represents positive change, cyan represents negative change, and white represents no change. C, A cumulative distribution function plot of relative fold change between 0 and 48 h of combined PITA, TargetScan/conservation, and TargetScan/context; top 50th percentile predictions in each, 2+ miRNAs targeting each gene. Target genes in red; nontarget genes in blue. D, Same as A with 4+ miRNAs targeting each gene. E, PITA, top 50th percentile predictions; 4+ miRNAs targeting a given gene. Target genes in red; nontarget genes in blue. F, PITA, top 50th percentile predictions with 7+ miRNAs targeting a given gene. Target genes in red; nontarget genes in blue. G, TargetScan/context score, top 50th percentile predictions; 4+ miRNAs targeting a given gene. Target genes in red; nontarget genes in blue. H, TargetScan/context score, top 50th percentile predictions; 7+ miRNAs targeting a given gene. Target genes in red; nontarget genes in blue. I, TargetScan/conservation score, top 50th percentile predictions; 4+ miRNAs targeting a given gene. Target genes in red; nontarget genes in blue. J, TargetScan/ conservation score, top 50th percentile predictions; 7+ miRNAs targeting a given gene. Target genes in red; nontarget genes in blue. The Journal of Immunology 2237

Table I. Differentially upregulated (.2-fold) miRNAs in activated Table II. Differentially downregulated miRNAs in activated T cells T cells detected 0 versus 48 detected 0 versus 48

miRNA p Value q-Value Fold Change miRNA p Value q-Value Fold Change hsa-miR-221 2.77 E-08 3.31 E-06 7881.6 hsa-miR-197 1.72 E-02 6.75 E-02 21.2 hsa-miR-210 2.12 E-04 2.54 E-03 1846.7 hsa-miR-146b 1.67 E-02 6.67 E-02 21.6 hsa-miR-98 8.96 E-04 6.69 E-03 237.6 hsa-miR-10a 1.95 E-02 7.52 E-02 21.6 hsa-miR-29b 1.97 E-03 1.27 E-02 194.7 hsa-miR-342-3p 1.88 E-04 2.37 E-03 21.7 hsa-miR-155 4.19 E-08 3.34 E-06 70.5 hsa-miR-26b 2.90 E-02 9.90 E-02 21.8 hsa-miR-218 4.80 E-03 2.55 E-02 45.4 hsa-miR-31 4.91 E-04 4.05 E-03 21.8 hsa-miR-455-5p 1.34 E-03 9.13 E-03 32.2 hsa-miR-328 9.47 E-05 1.33 E-03 21.9 hsa-miR-449 1.01 E-02 4.75 E-02 20.5 hsa-miR-95 2.58 E-03 1.54 E-02 22.1 hsa-miR-548d 9.97 E-03 4.76 E-02 18.8 hsa-miR-26a 2.96 E-03 1.72 E-02 22.4 hsa-miR-222 2.89 E-07 1.73 E-05 17.1 hsa-miR-150 4.30 E-05 8.56 E-04 23.0 hsa-miR-132 6.22 E-05 1.06 E-03 15.3 hsa-miR-125b 3.33 E-03 1.89 E-02 23.4 hsa-miR-18a 2.05 E-03 1.29 E-02 15.3 hsa-miR-99a 5.04 E-03 2.62 E-02 23.8 hsa-miR-18aa 7.19 E-09 1.72 E-06 15.0 hsa-miR-100 2.23 E-03 1.37 E-02 23.9 hsa-miR-200b 2.90 E-02 9.76 E-02 13.1 hsa-miR-376a 2.19 E-02 7.93 E-02 24.1 hsa-miR-330-3p 1.39 E-02 5.61 E-02 11.1 hsa-miR-126 1.19 E-03 8.34 E-03 25.2 hsa-miR-206 1.28 E-02 5.68 E-02 10.0 hsa-miR-127-3p 2.31 E-02 8.23 E-02 27.2 hsa-miR-17-5p 5.48 E-06 2.18 E-04 9.8 hsa-miR-224 1.31 E-02 5.60 E-02 27.9 hsa-miR-424 1.32 E-02 5.44 E-02 9.6 hsa-miR-223 4.05 E-05 8.80 E-04 28.7 Downloaded from hsa-miR-20b 2.34 E-06 1.12 E-04 9.0 hsa-miR-199aa 9.15 E-03 4.46 E-02 231.0 hsa-miR-106a 6.51 E-06 2.22 E-04 8.4 hsa-miR-181a 2.07 E-02 7.72 E-02 271.8 hsa-miR-7 7.05 E-05 1.05 E-03 8.3 Shown are significantly differentially downregulated miRNAs. hsa-miR-93 3.08 E-05 7.37 E-04 7.6 aq-value is the FDR threshold for the corresponding p value. hsa-miR-324-5p 1.37 E-05 4.09 E-04 6.4 hsa-miR-19a 2.89 E-04 2.76 E-03 6.3 hsa-miR-130b 2.51 E-04 2.50 E-03 6.1 http://www.jimmunol.org/ hsa-miR-20a 2.39 E-05 6.34 E-04 6.0 regulated miRNAs. The central node gene PIK3R1 belongs to the hsa-miR-301a 2.24 E-04 2.55 E-03 6.0 phosphoinositide 3-kinase family that phosphorylates phosphati- hsa-miR-27b 2.81 E-02 9.74 E-02 5.9 dylinositol-(4,5)-biphosphate to phosphatidylinositol-(3,4,5)-tri- hsa-miR-19b 2.24 E-04 2.43 E-03 5.8 phosphate to regulate cell proliferation, and cytokine production hsa-miR-99b 2.35 E-04 2.45 E-03 5.1 hsa-miR-629 4.60 E-04 4.07 E-03 4.7 (75). PIK3R1 is a predicted target of four miRNAs (miR-155, -21, hsa-miR-363 2.35 E-02 8.27 E-02 4.2 -218, and -221). Thus, downregulated gene targets of upregulated hsa-let-7f 1.30 E-02 5.65 E-02 3.8 activation-induced miRNAs are associated with proliferation and hsa-miR-21 3.68 E-03 2.00 E-02 3.7 cell survival signaling networks. We identified 12 other target gene hsa-miR-362-5p 1.77 E-03 1.18 E-02 3.7 networks (Supplemental Table III). hsa-miR-135b 6.35 E-04 5.06 E-03 3.5 by guest on September 27, 2021 hsa-miR-92a 5.26 E-05 9.67 E-04 3.4 Predicted targets of downregulated miRNAs are upregulated hsa-miR-106b 6.54 E-03 3.33 E-02 3.4 with activation hsa-miR-27a 3.41 E-03 1.90 E-02 3.1 hsa-miR-365 1.04 E-02 4.80 E-02 2.7 With respect to the impact of the 20 downregulated miRNAs, we hsa-miR-378 2.17 E-02 7.98 E-02 2.7 predicted 1347 gene targets out of the total of 3798 activation- hsa-miR-422a 1.64 E-04 2.18 E-03 2.6 hsa-miR-425-3p 8.26 E-03 4.11 E-02 2.5 induced genes. A total of 487 genes were only targeted by hsa-miR-24 6.69 E-05 1.07 E-03 2.3 downregulated miRNAs. In contrast, the majority (860) was also Shown are significantly differentially upregulated miRNAs with fold change .2- targeted by upregulated miRNAs, matching our observations on the fold. apparent importance of combinatorial targeting. We predicted that aq-value is the FDR threshold for the corresponding p value. targets of only downregulated miRNAs should have upregulated mRNA levels. Indeed, 410 (84%) were upregulated .1.5-fold. Pathway analysis revealed statistically significant enrichment for We mapped the functional pathways enriched for these two 71 canonical pathways (multiple test correction p value ,0.05), classes of targets. The pathways linked to only downregulated with the top 30 pathways shown in Fig. 2A. Represented were miRNAs are predominantly cell metabolism and biosynthesis. primarily immune signaling pathways including IL-12, PI3K, Because miRNAs targeting these genes are downregulated with IL-10, CD40, NFAT, sphingosine 1-phosphate, and TCR. Cell activation, the presumed regulation of their targets is removed or at survival, growth, and proliferation pathways included prolactin, least significantly decreased. The functional role of these genes in TNFR2, ceramide, thrombopoietin, and p70S6K signaling. In metabolism and biosynthesis, much like the genes we found were sharp contrast, differentially expressed genes that were not pre- not targeted by miRNAs, supports the observation that activation- dicted targets of miRNAs were highly enriched for metabolism induced miRNAs target a functionally distinct class of genes. In and biosynthesis pathways (Fig. 2B). contrast, the pathways linked to combinatorial targeting by both up- Molecular networks were constructed from the miRNA targets and downregulated miRNAs are enriched for signaling in immu- with downregulated expression. Network eligibility was based nity, growth, and cell proliferation (Fig. 3). on connectivity to other genes with known interactions. Highly connected genes represent network nodes or hubs where closely Correlating global protein expression to predicted miRNA connected genes are functionally similar. The top network was targets comprised of 21 genes significantly enriched for functions linked Our hypothesis was that upregulated miRNAs regulate the immune to T lymphocyte activation, proliferation, and survival (Fig. 2C). response and should repress target proteins during T lymphocyte The hub genes in this network are PIK3R1 with six connections activation. Target protein repression can be accomplished by either and ATM, PARK2, HIP1R, and NCAM1 with three connections inhibiting translation or enhancing mRNA degradation. Although it each. Members of this network are predicted targets for 17 up- has been shown that most translational repression is coupled to 2238 microRNA-REGULATED NETWORKS IN T CELL ACTIVATION

Table III. miRNA-processing machinery genes detected at 48 h postactivation

Fold Change Genea Definition Function 48 h versus 0 h miRNAs XPO5 Exportin-5 Mediates the nuclear export of miRNA precursors 4.30 miR-218, miR-24 RANGAP1 Ran GTPase-activating protein 1 mRNA processing and transport 1.60 ND EIF2C2/AGO2 Protein argonaute-2 Provides endonuclease activity to RISC; cleaves 3.84 ND siRNA/mRNA heteroduplexes bound to RISC SIP1/GEMIN2 Survival of motor neuron protein- Core component of the SMN complex, which plays 2.23 ND interacting protein 1 an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus GEMIN4 Gem-associated protein 4 Component of the SMN complex, which is required 1.59 miR-155 for pre-mRNA splicing in the nucleus GEMIN5 Gem-associated protein 5 Component of the SMN complex, which is required 2.13 ND for pre-mRNA splicing in the nucleus GEMIN6 Gem-associated protein 6 Component of the SMN complex, which is required 2.11 ND for pre-mRNA splicing in the nucleus GEMIN7 Gem-associated protein 7 Component of the SMN complex, which is required 1.90 ND for pre-mRNA splicing in the nucleus YBX1 Nuclease-sensitive element- Participates in different steps of mRNA biogenesis, 1.53 ND

binding protein 1 including mRNA transcription, processing, and Downloaded from transport from the nucleus into the cytoplasm, binds to splice sites in pre-mRNA, and regulates splice site selection ADARB1 dsRNA-specific editase 1 Binds to siRNA without editing them and suppresses 1.50 miR-218 siRNA-mediated RNA interference aThe FDR-adjusted p values of every gene are ,0.007. Shown are genes implicated in miRNA processing/biogenesis that were significantly differentially expressed between

0 and 48 h, with relative fold changes. http://www.jimmunol.org/ ND, miRNA not detected; RISC, RNA-induced silencing complexes; siRNA, short interfering RNA; SMN, survival of motor neuron; snRNP, small nuclear ribonucleoprotein. miRNA-mediated mRNA degradation (12, 14), we considered the Several network proteins demonstrated increased mRNA but possibility that some miRNA targets might be specifically re- decreased protein levels (Fig. 4B). LMNB1, a predicted target of pressed at the translational level without decreases in corre- miR-218 and miR-7, showed the highest mRNA upregulation by 7- sponding mRNAs. A focus exclusively on the downregulation of fold but was 1.5-fold down by protein. Inhibition of T lymphoblast mRNAs would miss such targets. Therefore, a high-throughput proliferation is associated with downregulation of LMNB1 protein shotgun proteomics protocol (66) was used to analyze global (78). CRKL is targeted by four miRNAs and involved in signal protein expression between 0 and 48 h. transduction through WIP, JNK, and ZAP70 (79). IQGAP1, tar- by guest on September 27, 2021 A total of 589 differentially expressed proteins and another 876 geted by two miRNAs, regulates lymphocyte cytoskeleton rear- proteins expressed uniquely at 0 or 48 h were identified. Correlat- rangement in the immune synapse (80). Thus, these multiple lines of ing the predicted gene targets of miRNAs to expressed proteins, evidence linking the top functional networks directly to T lympho- we identified 234 protein–mRNA transcript targets of upregulated cyte immunity underline the value of such mapping based on global miRNAs (Supplemental Table IV). Eighty-one of these proteins gene, protein, and miRNA expression. had decreased expression at 48 h. Interestingly, 70 of these protein targets have upregulated mRNA expression. Thus, these proteins Knockdown of miR-221 and miR-155 increases T lymphocyte are regulated by posttranscriptional mechanisms not coupled to proliferation by removing negative regulation of target genes mRNA decay. Functional analysis of these 81 downregulated The premise of target predictions and functional network mapping protein targets revealed significant enrichment for signaling path- is that upregulated miRNAs regulate genes that populate critical ways in immune response, cell cycle, growth, and prolifera- networks in T lymphocyte activation. To validate our approach, we tion (Fig. 4A). In contrast, the 153 upregulated protein targets knocked down two of the highest upregulated miRNAs: miR-221 were enriched for only four pathways: RAN signaling; glycolysis/ and miR-155. Validations were done using purified CD4+ T lym- gluconeogenesis; phenylalanine, tyrosine, and tryptophan bio- phocytes to simplify the cell subset composition and reflect our synthesis; and alanine and aspartate metabolism. recent finding that CD4+ T lymphocytes are selectively activated Because networks represent integration of multiple associa- and proliferatively expanded in the early posttransplant period tions, we examined the top 3 networks to identify 19 downregulated (81). We confirmed that miR-221 and 155 were significantly up- proteins as predicted targets of $1 miRNAs (Fig. 4B). Within regulated in CD4+ T cells at 48 h of activation (data not shown). these 19 genes was AHNA, targeted by miR-200b and miR-7, and Although the function of miR-155 has been widely studied in critical for calcium entry during immune T lymphocyte activation T cells (26, 41), miR-221 associated with cell cycle progression (76). AHNA was 2.2-fold down at the mRNA level and 8-fold (44) has not been studied in T lymphocytes. down at the protein level. ATM, targeted by miR-132, miR-18a, The impact of inhibiting miR-221 and -155 on T lymphocyte and miR-21, regulates cell cycle, promotes normal lymphocyte proliferation was measured by transfecting cells with specific development, and protects from neoplastic transformation (77). inhibitors or scrambled controls followed by activation. We ATM was 2.8-fold down by mRNA and 4.8-fold down by protein. obtained .60% knockdown of both miRNAs in three donors PIK3R1 is an adaptor kinase involved in TCR signaling and CD28 (n = 3) as measured by qPCR (Fig. 4C). Significantly increased costimulation with 3-fold mRNA and 2.6-fold protein downreg- proliferation resulted from inhibiting either miR-155 or -221 as ulation. It is a predicted target of four upregulated miRNAs (Fig. compared with scrambled control (Fig. 4D). 2C) and is identified as a downregulated network hub by both gene Among the predicted targets of miR-221 and miR-155, we chose expression and proteomics. four genes for validation by qPCR: PIK3R1, FOS, IRS2, and The Journal of Immunology 2239 Downloaded from http://www.jimmunol.org/ by guest on September 27, 2021

FIGURE 2. Functional analysis of predicted targets of upregulated miRNAs reveals networks associated with immunity, cell survival, and proliferation. A, Top 30 overrepresented canonical pathways for downregulated gene targets of upregulated miRNAs. Pathways are sorted by score (2log [multiple testing corrected p value]). A higher score indicates that the pathway is more significantly associated with genes of interest. The vertical line represents statistically significant threshold limit. B, Significantly overrepresented canonical pathways for nontarget differentially expressed genes 0 versus 48 h. C, Top direct interaction network representing 21 downregulated target focus genes, overlaid with predicted major miRNA targeting and functions associated with nodal genes.

IKBKE (Fig. 4E). FOS and IKBKE have been previously vali- stically increased by knocking down these two miRNAs. Although dated as targets of miR-221 (82) and -155 (83), respectively. At changes in IKBKE levels were not statistically significant, IRS2, 48 h after activation, the expression of FOS and PIK3R1 is stati- a predicted target of miR-155, increased expression after miR-155 2240 microRNA-REGULATED NETWORKS IN T CELL ACTIVATION Downloaded from http://www.jimmunol.org/ FIGURE 3. Functions of genes targeted by downregulated miRNAs. Top 30 overrepresented canonical pathways for gene targets of upregulated as well as downregulated miRNAs and downregulated miRNAs only. Pathways are sorted by score (2log [multiple testing corrected p value]). A higher score indicates that the pathway is more significantly associated with genes of interest. The horizontal line represents statistically significant threshold limit. The pathways linked to only downregulated miRNAs are predominantly cell metabolism and biosynthesis, much like the genes not targeted by miRNAs. In contrast, the pathways linked to combinatorial targeting by both up- and downregulated miRNAs are enriched for signaling in immunity, growth, and cell proliferation.

knockdown. Upregulation of target genes following knockdown First, if the results from all of the algorithms are compared using by guest on September 27, 2021 of miR-221 and -155 is consistent with the evidence above for a single miRNA hit/seed approach, the predicted targets are poorly mRNA repression mediated by miR-221 and/or -155 during correlated between methods to the extent that different methods T lymphocyte activation (Fig. 4F). will report very different results. Second, single hit/seed predictions did not correlate with mRNA repression. In contrast, combinatorial Discussion targeting (multiple seeds per target) gave the best predictions. We investigated genome-wide miRNA, mRNA, and protein ex- TargetScan conservation predictions with combinatorial binding of pression following human T lymphocyte activation. T lymphocyte four or more miRNAs showed the correlation between increased activation relies on signaling cascades that create a balance be- miRNA binding with decreased target gene expression. tween activation, memory, and quiescence. This balance is mod- By integrating activation-induced miRNA, mRNA, and protein ulated by mechanisms regulating gene expression including expression changes with target predictions, we tested our hy- posttranscriptional miRNA regulation. In this study, we show pothesis that target genes are involved in regulating immune ac- a unique miRNA signature with a total of 71 differentially ex- tivation, cell proliferation, and survival. Indeed, functional analysis pressed miRNAs with 51 upregulated between 0 and 48 h. This demonstrated that downregulated miRNA targets populated sig- signature comprises 57 miRNAs with no documented roles in naling pathways highly enriched for immune response, prolif- T lymphocyte function. Additionally, our data validated previous eration, and survival. In contrast, activation-induced genes not pre- findings for a number of miRNAs with known functions in T lym- dicted to be miRNA targets demonstrated significant enrichment phocytes: upregulation of miR-155 can regulate the susceptibi- for pathways of metabolism, DNA stability, and cell cycle. These lity of human and murine CD4+ T cells to natural regulatory T novel results reveal that predicted targets of activation-induced cell-mediated suppression (26), the miR-17–92 cluster inhibits miRNAs are functionally distinct from nontarget genes and pre- T cell activation (30, 32), miR-106a is implicated in IL-10 regu- sumably evolved with distinct selection pressures for such regu- lation (31, 33), miR-24 can inhibit cell proliferation by targeting lation. We also hypothesized that some targets might be specifically cell-cycle genes (6, 47), and miR-21, upregulated by STAT3, regulated by posttranscriptional mechanisms not coupled to mRNA prevents CD4+ T cell apoptosis and is implicated in lymphocyte decay. Based on our proteomics, we detected a number of such oncogenesis (18, 53). Also, consistent with the importance of downregulated protein targets despite increased mRNA expression. activation-induced miRNA expression, we observed upregulation Thus, inhibition of protein translation is not always coupled to of 10 miRNA biogenesis/processing machinery genes. corresponding mRNA degradation. miRNAs are known inhibitors of gene expression. The challenge By investigating connectivity between predicted targets, we is to map miRNAs to specific gene targets and the molecular net- identified highly connected genes that function as network nodes, works they regulate. To address this challenge, we investigated the with closely connected genes being functionally similar. The top predictive values of four widely used computational algorithms. nodal gene PIK3R1 of one such network is a predicted target of The Journal of Immunology 2241

FIGURE 4. Inhibition of miR-155 (known) and miR-221 (novel), two highly upregulated miRNAs, in CD4+ T cells increased proliferation by removing suppression of four target genes linked to proliferation and survival. A, Top 30 overrepresented canonical pathways for down- regulated protein targets of upregulated miRNAs. Pathways are sorted by score. B, Expression of 19 predicted downregulated protein targets as- Downloaded from sociated with top three networks. C, qPCR ex- pression of miR-155 and miR-221 in CD4+ T cells nucleoporated with 50 nM LNA–anti- miR-155 (gray bar), LNA–anti-miR-221 (black bar), or LNA-scrambled control (white bar) showing decreased miRNA expression after LNA–anti-miR transfection relative to scrambled http://www.jimmunol.org/ control, set as 1. Shown are fold changes relative to scrambled control, normalized to U6 snRNA. D, Increased cell proliferation following knock- down of miR-221 (black bar) or miR-155 (gray bar) compared with scrambled control (white bar) by cell proliferation assay. E, qPCR analysis of predicted targets in CD4+ T cells transfected with LNA–anti-miR-155 (gray), LNA–anti-miR- 221 (black), and LNA scrambled control (white), presented relative to the expression in scrambled by guest on September 27, 2021 control sample, set as 1. F, Proposed model of miR-155 and -221 negative-feedback regulation of proliferation following T cell activation. CD3/ CD28 costimulation induces signaling cascades that result in transcription of genes that promote proliferation, activation, and immune response. Upregulation of miR-155 and -221 serves to di- minish proliferation and immune response by targeting key proliferative genes such as PIK3R1, IRS2, and IKBKE as well as transcription factor FOS. Error bars in C–E represent mean 6 SEM of triplicate experiments from three donors (n = 3). *p , 0.05, ***p , 0.0001 (t test) compared with scrambled control.

miR-221 and -155 and downregulated at both mRNA and protein In validation, we focused on the functional roles of two top levels. This gene is an adaptor kinase involved in TCR signaling upregulated miRNAs in our data: miR-155, widely studied in and CD28 costimulation and regulates cell growth, proliferation, T cells, and miR-221, not previously associated with T cell and T cell cytokine production (75). Thus, functional network function. Knockdown of either miRNA produced a significant in- analysis underlines the value of the mapping done in this study crease in proliferation of activated CD4+ T cells, confirming that based on global gene, protein, and miRNA expression. these two miRNAs actually have antiproliferative roles during 2242 microRNA-REGULATED NETWORKS IN T CELL ACTIVATION activation. We identified four potential targets of miR-155 and/or 16. Cobb, B. S., A. Hertweck, J. Smith, E. O’Connor, D. Graf, T. Cook, S. T. Smale, S. Sakaguchi, F. J. Livesey, A. G. Fisher, and M. Merkenschlager. 2006. A role -221 and mapped a functional network critical to T cell activation for Dicer in immune regulation. J. Exp. Med. 203: 2519–2527. (Fig. 4F). In addition to identifying PIK3R1 as a new target gene 17. Monticelli, S., K. M. Ansel, C. Xiao, N. D. Socci, A. M. Krichevsky, T. H. Thai, for miR-155 and -221, we discovered that the transcription factor N. Rajewsky, D. S. Marks, C. Sander, K. Rajewsky, et al. 2005. MicroRNA profiling of the murine hematopoietic system. Genome Biol. 6: R71. FOS is also a target of both miR-155 and -221. We identified two 18. Wu, H., J. R. Neilson, P. Kumar, M. Manocha, P. Shankar, P. A. Sharp, and more targets of miR-155: the novel IRS2, an adaptor for tyrosine N. Manjunath. 2007. miRNA profiling of naı¨ve, effector and memory CD8 kinases, and a previously verified miR-155 target, IKBKE, that T cells. PLoS ONE 2: e1020. 19. Zhou, B., S. Wang, C. Mayr, D. P. Bartel, and H. F. Lodish. 2007. miR-150, regulates NF-kB activation (83). Knockdown of miR-221 and/or a microRNA expressed in mature B and T cells, blocks early B cell development -155 increased target mRNA expression for PIK3R1, FOS, and when expressed prematurely. Proc. Natl. Acad. Sci. USA 104: 7080–7085. IRS2. 20. Li, J., Y. Wan, Q. Guo, L. Zou, J. Zhang, Y. Fang, J. Zhang, J. Zhang, X. Fu, H. Liu, et al. 2010. Altered microRNA expression profile with miR-146a up- In conclusion, we propose a model in which, in the course of regulation in CD4+ T cells from patients with rheumatoid arthritis. Arthritis Res. T lymphocyte activation by TCR engagement and CD28 costim- Ther. 12: R81. 21. Cullen, B. R. 2006. Viruses and microRNAs. Nat. Genet. 38(Suppl): S25–S30. ulation, there is a significant upregulation of miRNAs that are 22. Cimmino, A., G. A. Calin, M. Fabbri, M. V. Iorio, M. Ferracin, M. Shimizu, critical to this process. These activation-induced miRNAs create S. E. Wojcik, R. I. Aqeilan, S. Zupo, M. Dono, et al. 2005. miR-15 and miR-16 a negative-feedback loop to inhibit cell proliferation and regulate induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. USA 102: 13944– 13949. cell survival by targeting a series of molecular networks that we 23. Dorsett, Y., K. M. McBride, M. Jankovic, A. Gazumyan, T. H. Thai, have mapped. In parallel, there is also a subset of miRNAs D. F. Robbiani, M. Di Virgilio, B. Reina San-Martin, G. Heidkamp, downregulated by activation, and 84% of their predicted target T. A. Schwickert, et al. 2008. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 28: 630–638. genes are shown to be upregulated at the mRNA level. Moreover, 24. O’Connell, R. M., A. A. Chaudhuri, D. S. Rao, and D. Baltimore. 2009. Inositol Downloaded from there is a functionally specific class of genes linked closely to the phosphatase SHIP1 is a primary target of miR-155. Proc. Natl. Acad. Sci. USA immune response that evolved to be the natural targets of these 106: 7113–7118. 25. Rodriguez, A., E. Vigorito, S. Clare, M. V. Warren, P. Couttet, D. R. Soond, miRNAs in T lymphocytes, with functions revealed by molecular S. van Dongen, R. J. Grocock, P. P. Das, E. A. Miska, et al. 2007. Requirement of networking mapping that are clearly distinct from the activation- bic/microRNA-155 for normal immune function. Science 316: 608–611. 26. Stahl, H. F., T. Fauti, N. Ullrich, T. Bopp, J. Kubach, W. Rust, P. Labhart, induced genes that are not miRNA targets. V. Alexiadis, C. Becker, M. Hafner, et al. 2009. miR-155 inhibition sensitizes

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Table S1: miRNAs documented to play a role in hematopoietic cell lineage. Our review of the literature summarizing miRNAs known to be involved in the development and proliferation of the hematopoietic lineage cells. miRNA Expression/function/target/regulator References miR-150 Elevated during developmental stages of B and T cell maturation. 16-19 Controls B cell differentiation, present in mature, resting T and B cells but decreased upon activation of naïve T or B cells. Plays a role in establishing lymphocyte identity. Very little is known about function in T cells. Regulators: Foxp3 Target: C-Myb miR-146a/b Upregulated in macropgahe inflammatory response. Differentially 17, 20 upregulated in murine Th1 subset but abolished in Th2 subset. Upregulated in response to TCRs stimulation, as well as by IL-1 and TNF. Highly expressed in murine T-regs and could play a role in establishing lymphocyte identity. Modulates activation induced cell death in activated T cells. Negative regulator of TLR and cytokine signaling pathway. Endotoxin tolerance. Antiviral role. Targets: IRAK1, IRAK2, TRAF6, FAF1 miR-16-1 Promote apoptosis by targeting Bcl2 expression, act as tumor 22 cluster suppressor RNAs. May block differentiation of later stage hematopoietic progenitor cells to mature cells. Downregulated in CLL. Target: BCL2. miR-155 Regulator of T and B cell maturation and innate immune response. 23-29 Expressed in primary mediastinal B-cell lymphoma, T and B cells, macrophages and DCs. Upregulated during B cell activation. Involved in T cell differentiation and indicated as a positive regulator of cytokine production. Activated by stimulating TLR3 and INFab receptors in bone derived macrophages (regulation of antimicrobial defense). Associated with EBV latency type-III infection. Targets: AGTR1, PU.1, c-Maf. SHIP1, AID, SOSC1, BACH1, CEBPB, CSFR, TAB2, MAF, JARID2 Regulators: FOXP3 in Tregs, C-MYC in B cells, AP-1 and NF-kB miR-17-92 Consists of miR-17, -18a, -19a, -20a, -19b-1,–92-1, and 106a. 30-33 cluster: Over-expressed in lymphomas and other hematological miR-17 malignancies, suppress cell death, increase lymphogenesis, miR-18a regulator of T and B cell development, inhibit monocyte miR-19a proliferation, differentiation and maturation. miR-20a Targets: E2F1, BIM, PTEN, IL10 miR-19b Regulator: C-MYC miR-92a miR-106a miR-32 Direct negative effect on replication of PFV-1 virus by 21 downregulating of replication-essential viral proteins encoded by ORF2 miR-132 CREB-responsive gene that regulates neuronal outgrowth in rats by 34-35 controlling p250GAP protein expression. Endotoxin-responsive gene, LPS signaling. Differentially unregulated in six solid cancer types. Megakaryocytic differentiation miR-181a B and T cell Hematopoiesis. Positive regulator for B cell 36-37 differentiation, tentative negative T cell development regulator. Regulates sensitivity of T-cell Receptor, regulates T cell selection during thymic development, present in immature thymocytes. Changes in miR-181a levels might function as a rheostat by regulating protein phosphorylation levels. Targets:TCL1, HOXA11, DUSP5, DUSP6, SHP2 and PTPN22 miR-181b Implicated in regulation of B cell function by affecting class- 38 switching recombination miR-181c Human activated CD4(+) T lymphocytes increase IL-2 expression 39 by downregulating microRNA-181c. miR-181c was proven to have the potential to regulate CD4(+) T cell activation. miR-181c was downregulated in the process of CD4(+) T cell activation, can bind to the IL-2 3' UTR and repress its expression by inhibiting translation. Moreover, miR-181c mimics reduced activated CD4(+) T cell proliferation. miR-142 Early hematopoietic development, T-cell lineage, translocated in 40-41, 18 miR-142-3p B-PLL patients. Expressed in Tregs, repressed by FOXP3, leading to increased production of cyclic AMP and suppressor function of T-reg cells. Target: AC9 miR-223 Expression in T-lineage cells, negative regulator of neutrophil 41-43 proliferation and activation, enhances T cell differentiation. Targets: Mef2c, IGFR Regulators: PU.1, C/EBP alpha, NFI-A miR-221 Highly-expressed in human cord-blood derived hematopoietic 44-45 miR-222 CD34+ progenitor cells. Down regulated in response to erythroid lineage differentiation. Controls terminal stages in hematopoietic development. Target: c-kit miR-214 Targets Pten in activated murine T cells and its expression leads to 46 increased T cell proliferation in mice. Furthermore, upregulation of miR-214 was dependent on CD28 costimulation Target: Pten miR-24 miR-24 is consistently upregulated during terminal differentiation 47 of hematopoietic cell lines into a variety of lineages, miR-24 is also upregulated during thymic development to naive CD8 T cells. miR-103 Block differentiation of hematopoietic stem-progenitor cells 48 miR-107 (HSPC) at a later stage in HSPC development miR-29 Linked with aggressive CLL phenotype. 49 Target: TCL1 miR-LET-7e Upregulated in APL patients upon retinoic acid treatment 50 mIR-342 miR-130a Megakaryocytic differentiation. 50 Target: MAFB miR-21 Upregulated during macrophage inflammatory response. MiR-21 51-53 miR-147 upregulated in CD4+ T cells upon IL-21 stimulation and regulated miR-9 by STAT3. In peripheral human monocytes and neutrophils miR-9 is similarly upregulated by pro-inflammatory signals. Target: BCL2 miR-144 Direct targets of the critical hematopoietic transcription factor 54 miR-451 GATA-1. Required for erythropoiesis miR-129 Targets genes related to miRNAs processing or transcription 55 regulation miR-520h May promote differentiation of HSCs into progenitor cells by 55 inhibiting ABCG2 expression miR-125b Expressed in centroblasts and shown to repress PRDM1 and IRF4 55 miR-125b-1 Involved in translocation in B-ALL case 56 miR-122 Required for hepatitis C proliferation in liver 57 miR-10 miR-196b is regulated by the HSC transcription factor family 58-60 miR-196b mixed lineage leukaemia (MLL), and has a functional role in miR-126 modulating HSC homeostasis and lineage commitment, could directly repress HOX family expression, important roles in regulating HSC homeostasis. miR-126 has also been shown to regulate expression of HOXA9 and PLK2 miR-326 Expressed in T cells, promotes TH17 cell development both in 61 vitro and in vivo by targeting ETS1 miR-101 Differentially expressed in human naive, memory and TFH CD4+ 62-63 cells and inversely correlates to ICOS expression in these subsets, with the highest levels found in naive (ICOSneg) cells, intermediate levels in memory cells (ICOSint) and lowest levels in TFH cells (ICOShigh) miR-184 Inhibits NFAT1 protein expression elicited by UCB CD4+ T cells. 64 Endogenous expression of miR-184 in UCB is 58.4-fold higher compared with AB CD4+ T cells, and miR-184 blocks production of NFAT1 protein through its complementary target sequence on the NFATc2 mRNA without transcript degradation.

avg-T0 log2_fold- fold- rawp- adjp- Symbol Ensembl_gene Definition log2 avg-T48 log2 T48_vs_T0 T48_vs_T0 T48_vs_T0 T48_vs_T0 ANOVA-rawp ANOVA-adjp largest fold #Mirs Mir List (includes only miRs upregulated as determined by t-test) Proto-oncogene protein c-fos (Cellular oncogene fos)(G0/G1 switch FOS ENSG00000170345 regulatory protein 7) [Source:UniProtKB/Swiss-Prot;Acc:P01100] 10.24 6.08 -4.16 -17.86 4.87E-15 5.13E-12 4.58E-28 4.10E-24 4.69 2 hsa-miR-155,hsa-miR-221, Dual specificity protein phosphatase 1 (EC 3.1.3.48)(EC 3.1.3.16)(MAP kinase phosphatase 1)(MKP-1)(Protein-tyrosine phosphatase CL100)(Dual specificity protein phosphatase hVH1) DUSP1 ENSG00000120129 [Source:UniProtKB/Swiss-Prot;Acc:P28562] 10.79 7.09 -3.70 -13.03 2.72E-11 4.94E-09 2.91E-21 2.54E-18 4.32 1 hsa-miR-200b, Protein fosB (G0/G1 switch regulatory protein 3) FOSB ENSG00000125740 [Source:UniProtKB/Swiss-Prot;Acc:P53539] 9.00 6.04 -2.96 -7.79 3.22E-14 2.31E-11 1.84E-26 1.10E-22 3.36 1 hsa-miR-27a, Integrin alpha-6 Precursor (VLA-6)(CD49 antigen-like family member F)(CD49f antigen) [Contains Integrin alpha-6 heavy chain;Integrin ITGA6 ENSG00000091409 alpha-6 light chain] [Source:UniProtKB/Swiss-Prot;Acc:P23229] 7.94 5.09 -2.85 -7.20 1.15E-08 6.54E-07 3.42E-15 3.26E-13 3.25 2 hsa-miR-19a,hsa-miR-29b, Krueppel-like factor 3 (Basic krueppel-like factor)(CACCC-box- binding protein BKLF)(TEF-2) [Source:UniProtKB/Swiss- hsa-miR-130b,hsa-miR-132,hsa-miR-135b,hsa-miR-155,hsa-miR-20a,hsa-miR- KLF3 ENSG00000109787 Prot;Acc:P57682] 8.69 6.02 -2.67 -6.38 3.50E-09 2.46E-07 3.67E-16 4.61E-14 2.87 9 218,hsa-miR-221,hsa-miR-27a,hsa-miR-365, Nuclear receptor subfamily 4 group A member 2 (Orphan nuclear receptor NURR1)(Immediate-early response protein NOT)(Transcriptionally-inducible nuclear receptor) NR4A2 ENSG00000153234 [Source:UniProtKB/Swiss-Prot;Acc:P43354] 9.57 7.04 -2.53 -5.77 2.88E-07 8.90E-06 9.78E-14 6.06E-12 3.31 4 hsa-miR-132,hsa-miR-200b,hsa-miR-206,hsa-miR-365, V-set and immunoglobulin domain-containing protein 1 Precursor (Cell surface A33 antigen)(Glycoprotein A34) VSIG1 ENSG00000101842 [Source:UniProtKB/Swiss-Prot;Acc:Q86XK7] 6.69 4.20 -2.50 -5.64 2.16E-07 7.08E-06 1.69E-15 1.73E-13 2.89 2 hsa-miR-155,hsa-miR-365, Thioredoxin-interacting protein (Vitamin D3 up-regulated protein 1)(Thioredoxin-binding protein 2) [Source:UniProtKB/Swiss- TXNIP ENSG00000117289 Prot;Acc:Q9H3M7] 10.18 7.70 -2.48 -5.56 8.44E-08 3.26E-06 5.01E-13 2.47E-11 2.77 1 hsa-miR-18a, Cytochrome b-245 heavy chain (EC 1.-.-.-)(p22 phagocyte B- cytochrome)(Neutrophil cytochrome b 91 kDa polypeptide)(Heme- binding membrane glycoprotein gp91phox)(CGD91-phox)(gp91- phox)(gp91-1)(Cytochrome b(558) subunit beta)(Cytochrome b558 CYBB ENSG00000165168 subunit beta)(Sup 7.25 4.89 -2.36 -5.14 2.89E-09 2.10E-07 6.39E-17 9.99E-15 2.43 2 hsa-miR-132,hsa-miR-7, Sex comb on midleg-like protein 1 [Source:UniProtKB/Swiss- SCML1 ENSG00000047634 Prot;Acc:Q9UN30] 6.95 4.67 -2.28 -4.86 3.18E-06 6.34E-05 5.51E-11 1.53E-09 2.57 1 hsa-miR-24, TSC22 domain family protein 3 (Glucocorticoid-induced leucine zipper protein)(Delta sleep-inducing peptide immunoreactor)(DSIP- immunoreactive peptide)(Protein DIP)(hDIP)(TSC-22-like TSC22D3 ENSG00000157514 protein)(TSC-22R) [Source:UniProtKB/Swiss-Prot;Acc:Q99576] 9.29 7.09 -2.20 -4.59 2.44E-09 1.81E-07 3.24E-19 1.24E-16 3.41 2 hsa-miR-221,hsa-miR-24, Regulator of G-protein signaling 1 (RGS1)(Early response protein 1R20)(B-cell activation protein BL34) [Source:UniProtKB/Swiss- RGS1 ENSG00000090104 Prot;Acc:Q08116] 9.81 7.65 -2.16 -4.48 1.89E-06 4.13E-05 8.21E-11 2.16E-09 3.13 1 hsa-miR-27a, YPEL5 ENSG00000119801 Protein yippee-like 5 [Source:UniProtKB/Swiss-Prot;Acc:P62699] 9.56 7.43 -2.13 -4.37 1.58E-08 8.48E-07 4.65E-12 1.72E-10 2.79 1 hsa-miR-18a, Tristetraproline (TTP)(Zinc finger protein 36 homolog)(Zfp- 36)(Protein TIS11A)(TIS11)(Growth factor-inducible nuclear protein NUP475)(G0/G1 switch regulatory protein 24) ZFP36 ENSG00000128016 [Source:UniProtKB/Swiss-Prot;Acc:P26651] 9.89 7.77 -2.12 -4.34 1.33E-07 4.78E-06 2.31E-14 1.69E-12 2.95 4 hsa-miR-155,hsa-miR-221,hsa-miR-27a,hsa-miR-29b, SAM domain and HD domain-containing protein 1 (Dendritic cell- derived IFNG-induced protein)(DCIP)(Monocyte protein 5)(MOP-5) SAMHD1 ENSG00000101347 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y3Z3] 8.99 6.90 -2.09 -4.27 1.10E-07 4.09E-06 1.55E-08 2.22E-07 2.09 1 hsa-miR-155, Phosphoinositide-3-kinase-interacting protein 1 Precursor (Kringle domain-containing protein HGFL) [Source:UniProtKB/Swiss- PIK3IP1 ENSG00000100100 Prot;Acc:Q96FE7] 8.74 6.69 -2.05 -4.14 6.33E-07 1.68E-05 1.13E-14 9.18E-13 2.84 2 hsa-miR-132,hsa-miR-206, Transcription factor AP-1 (Activator protein 1)(AP1)(Proto-oncogene c-jun)(V-jun avian sarcoma virus 17 oncogene homolog)(p39) JUN ENSG00000177606 [Source:UniProtKB/Swiss-Prot;Acc:P05412] 9.41 7.37 -2.04 -4.10 1.34E-05 2.00E-04 3.44E-13 1.79E-11 3.18 2 hsa-miR-200b,hsa-miR-24, ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like protein 7)(ADP-ribosylation factor-like protein LAK) ARL4C ENSG00000188042 [Source:UniProtKB/Swiss-Prot;Acc:P56559] 9.89 7.91 -1.98 -3.96 8.73E-09 5.16E-07 4.87E-14 3.26E-12 2.38 3 hsa-miR-155,hsa-miR-27a,hsa-miR-7, Nuclear receptor subfamily 1 group D member 2 (Rev-erb-beta)(EAR- 1R)(Orphan nuclear hormone receptor BD73) NR1D2 ENSG00000174738 [Source:UniProtKB/Swiss-Prot;Acc:Q14995] 7.63 5.78 -1.84 -3.59 4.73E-05 5.58E-04 1.85E-11 5.82E-10 2.94 2 hsa-miR-155,hsa-miR-27a, CX3C chemokine receptor 1 (C-X3-C CKR-1)(CX3CR1)(Fractalkine receptor)(G-protein coupled receptor 13)(V28)(Beta chemokine receptor-like 1)(CMK-BRL-1)(CMKBLR1) [Source:UniProtKB/Swiss- CX3CR1 ENSG00000168329 Prot;Acc:P49238] 7.57 5.74 -1.83 -3.55 6.08E-09 3.91E-07 1.55E-10 3.79E-09 1.83 2 hsa-miR-24,hsa-miR-7, Macrophage-expressed gene 1 protein Precursor (Macrophage gene MPEG1 ENSG00000197629 1 protein)(Mpg-1) [Source:UniProtKB/Swiss-Prot;Acc:Q2M385] 7.36 5.54 -1.82 -3.53 3.27E-07 9.82E-06 1.34E-12 5.80E-11 1.83 3 hsa-miR-155,hsa-miR-210,hsa-miR-7, Sex comb on midleg-like protein 4 [Source:UniProtKB/Swiss- SCML4 ENSG00000146285 Prot;Acc:Q8N228] 7.12 5.41 -1.71 -3.28 6.16E-07 1.65E-05 4.61E-14 3.11E-12 2.05 3 hsa-miR-130b,hsa-miR-155,hsa-miR-7, Killer cell lectin-like receptor subfamily G member 1 (Mast cell function-associated antigen)(MAFA-like receptor)(ITIM-containing receptor MAFA-L)(C-type lectin domain family 15 member A) KLRG1 ENSG00000139187 [Source:UniProtKB/Swiss-Prot;Acc:Q96E93] 7.80 6.10 -1.70 -3.25 2.26E-04 2.01E-03 1.64E-06 1.44E-05 2.02 1 hsa-miR-365, FAM65B ENSG00000111913 Protein FAM65B [Source:UniProtKB/Swiss-Prot;Acc:Q9Y4F9] 8.75 7.08 -1.67 -3.19 1.27E-04 1.26E-03 2.42E-08 3.33E-07 2.29 2 hsa-miR-218,hsa-miR-27a, Interleukin-12 subunit alpha Precursor (IL-12A)(IL-12 subunit p35)(Cytotoxic lymphocyte maturation factor 35 kDa subunit)(CLMF p35)(NK cell stimulatory factor chain 1)(NKSF1) IL12A ENSG00000168811 [Source:UniProtKB/Swiss-Prot;Acc:P29459] 7.44 5.81 -1.63 -3.10 2.53E-08 1.25E-06 8.09E-11 2.13E-09 1.79 1 hsa-miR-21, Prostaglandin D2 receptor (Prostanoid DP receptor)(PGD receptor) PTGDR ENSG00000168229 [Source:UniProtKB/Swiss-Prot;Acc:Q13258] 6.89 5.27 -1.62 -3.08 1.43E-06 3.30E-05 8.54E-09 1.30E-07 1.64 2 hsa-miR-27a,hsa-miR-365, Cat eye syndrome critical region protein 1 Precursor CECR1 ENSG00000093072 [Source:UniProtKB/Swiss-Prot;Acc:Q9NZK5] 6.68 5.07 -1.61 -3.05 1.75E-07 5.95E-06 6.55E-12 2.34E-10 1.61 1 hsa-miR-7, Potassium voltage-gated channel subfamily A member 3 (Voltage- gated potassium channel subunit Kv1.3)(HPCN3)(HGK5)(HuKIII)(HLK3) [Source:UniProtKB/Swiss- KCNA3 ENSG00000177272 Prot;Acc:P22001] 8.73 7.15 -1.58 -2.99 2.64E-04 2.28E-03 3.20E-04 1.67E-03 1.58 1 hsa-miR-155, Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85 subunit alpha)(PtdIns-3-kinase p85-alpha)(PI3K) PIK3R1 ENSG00000145675 [Source:UniProtKB/Swiss-Prot;Acc:P27986] 7.94 6.37 -1.57 -2.98 2.41E-04 2.12E-03 2.82E-08 3.80E-07 2.19 4 hsa-miR-155,hsa-miR-21,hsa-miR-218,hsa-miR-221, Transmembrane protein C16orf54 [Source:UniProtKB/Swiss- C16orf54 ENSG00000185905 Prot;Acc:Q6UWD8] 8.12 6.56 -1.56 -2.95 7.19E-08 2.88E-06 1.35E-15 1.44E-13 1.90 1 hsa-miR-155, Low affinity immunoglobulin gamma Fc region receptor II-a Precursor (IgG Fc receptor II-a)(Fc-gamma RII-a)(Fc-gamma-RIIa)(FcRII- a)(CDw32)(CD32 antigen) [Source:UniProtKB/Swiss- FCGR2A ENSG00000143226 Prot;Acc:P12318] 6.71 5.16 -1.55 -2.93 2.33E-06 4.90E-05 7.44E-09 1.15E-07 1.67 2 hsa-miR-221,hsa-miR-7, Complement receptor type 1 Precursor (C3b/C4b receptor)(CD35 CR1 ENSG00000203710 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P17927] 6.85 5.33 -1.51 -2.86 1.20E-09 1.02E-07 3.51E-16 4.45E-14 1.58 1 hsa-miR-210, Serine-protein kinase ATM (EC 2.7.11.1)(Ataxia telangiectasia ATM ENSG00000149311 mutated)(A-T, mutated) [Source:UniProtKB/Swiss-Prot;Acc:Q13315] 8.13 6.63 -1.50 -2.82 4.44E-04 3.50E-03 3.41E-08 4.52E-07 2.29 3 hsa-miR-132,hsa-miR-18a,hsa-miR-21, Ephrin type-A receptor 4 Precursor (EC 2.7.10.1)(Tyrosine-protein kinase receptor SEK)(Receptor protein-tyrosine kinase HEK8)(Tyrosine-protein kinase TYRO1) [Source:UniProtKB/Swiss- EPHA4 ENSG00000116106 Prot;Acc:P54764] 7.02 5.59 -1.43 -2.69 3.84E-06 7.31E-05 4.25E-12 1.60E-10 1.71 2 hsa-let-7f,hsa-miR-18a, Ectoderm-neural cortex protein 1 (ENC-1)(p53-induced gene 10 protein)(Nuclear matrix protein NRP/B)(Kelch-like protein 37) ENC1 ENSG00000171617 [Source:UniProtKB/Swiss-Prot;Acc:O14682] 6.72 5.32 -1.39 -2.63 5.45E-07 1.49E-05 1.43E-11 4.62E-10 1.58 5 hsa-miR-132,hsa-miR-18a,hsa-miR-19a,hsa-miR-222,hsa-miR-27a, Insulin receptor substrate 2 (IRS-2) [Source:UniProtKB/Swiss- IRS2 ENSG00000185950 Prot;Acc:Q9Y4H2] 7.47 6.09 -1.38 -2.61 6.41E-09 4.08E-07 5.23E-18 1.22E-15 1.74 2 hsa-miR-155,hsa-miR-7, Probable ATP-dependent RNA helicase DDX60-like (EC 3.6.1.- )(DEAD box protein 60-like) [Source:UniProtKB/Swiss- DDX60L ENSG00000181381 Prot;Acc:Q5H9U9] 6.54 5.18 -1.35 -2.55 4.60E-05 5.46E-04 1.30E-09 2.46E-08 1.79 1 hsa-miR-155, SNF-related serine/threonine-protein kinase (EC 2.7.11.1)(SNF1- SNRK ENSG00000163788 related kinase) [Source:UniProtKB/Swiss-Prot;Acc:Q9NRH2] 8.70 7.36 -1.34 -2.54 1.07E-04 1.09E-03 1.51E-08 2.17E-07 1.71 3 hsa-miR-18a,hsa-miR-21,hsa-miR-365, Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein) [Source:UniProtKB/Swiss- LDLRAP1 ENSG00000157978 Prot;Acc:Q5SW96] 7.83 6.49 -1.34 -2.53 1.09E-05 1.69E-04 2.78E-09 4.80E-08 1.45 2 hsa-miR-18a,hsa-miR-20b, TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30)(Poly [ADP-ribose] polymerase 7)(PARP-7) [Source:UniProtKB/Swiss- TIPARP ENSG00000163659 Prot;Acc:Q7Z3E1] 8.71 7.38 -1.33 -2.52 4.53E-04 3.56E-03 3.20E-07 3.33E-06 1.84 1 hsa-miR-221, E3 ubiquitin-protein ligase MYLIP (EC 6.3.2.-)(Myosin regulatory light chain-interacting protein)(MIR) [Source:UniProtKB/Swiss- MYLIP ENSG00000007944 Prot;Acc:Q8WY64] 8.75 7.43 -1.32 -2.50 1.45E-04 1.40E-03 2.92E-09 5.02E-08 2.01 4 hsa-miR-130b,hsa-miR-19a,hsa-miR-221,hsa-miR-365, Arrestin domain-containing protein 2 [Source:UniProtKB/Swiss- ARRDC2 ENSG00000105643 Prot;Acc:Q8TBH0] 8.10 6.79 -1.32 -2.49 1.03E-05 1.61E-04 7.22E-11 1.94E-09 1.74 3 hsa-miR-155,hsa-miR-365,hsa-miR-7, Protein BTG1 (B-cell translocation gene 1 protein) BTG1 ENSG00000133639 [Source:UniProtKB/Swiss-Prot;Acc:P62324] 10.27 8.98 -1.29 -2.45 4.38E-05 5.22E-04 1.31E-10 3.28E-09 2.27 2 hsa-miR-19a,hsa-miR-27a, Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CsGalNAcT- 1)(EC 2.4.1.174)(Chondroitin beta-1,4-N- acetylgalactosaminyltransferase 1)(Beta4GalNAcT-1) CSGALNACT ENSG00000147408 [Source:UniProtKB/Swiss-Prot;Acc:Q8TDX6] 7.16 5.88 -1.27 -2.42 2.43E-05 3.25E-04 1.03E-11 3.47E-10 1.90 1 hsa-miR-218, Period circadian protein homolog 1 (Circadian clock protein PERIOD 1)(Circadian pacemaker protein Rigui)(hPER1) PER1 ENSG00000179094 [Source:UniProtKB/Swiss-Prot;Acc:O15534] 7.66 6.39 -1.27 -2.41 2.72E-07 8.52E-06 1.93E-14 1.45E-12 1.55 1 hsa-miR-24, RING finger protein 139 (Translocation in renal carcinoma on RNF139 ENSG00000170881 chromosome 8) [Source:UniProtKB/Swiss-Prot;Acc:Q8WU17] 8.68 7.46 -1.22 -2.33 1.04E-04 1.06E-03 2.09E-06 1.80E-05 1.29 2 hsa-miR-218,hsa-miR-27a, Protein Tob1 (Transducer of erbB-2 1) [Source:UniProtKB/Swiss- TOB1 ENSG00000141232 Prot;Acc:P50616] 9.00 7.79 -1.21 -2.31 5.63E-04 4.28E-03 2.20E-05 1.50E-04 1.27 2 hsa-miR-200b,hsa-miR-218, Transforming growth factor-beta-induced protein ig-h3 Precursor (Beta ig-h3)(Kerato-epithelin)(RGD-containing collagen-associated TGFBI ENSG00000120708 protein)(RGD-CAP) [Source:UniProtKB/Swiss-Prot;Acc:Q15582] 7.35 6.15 -1.20 -2.30 1.92E-07 6.44E-06 4.45E-12 1.66E-10 1.25 1 hsa-miR-21, Mineralocorticoid receptor (MR)(Nuclear receptor subfamily 3 group NR3C2 ENSG00000151623 C member 2) [Source:UniProtKB/Swiss-Prot;Acc:P08235] 7.17 6.00 -1.18 -2.26 7.89E-06 1.31E-04 2.37E-10 5.52E-09 1.25 4 hsa-miR-155,hsa-miR-19a,hsa-miR-210,hsa-miR-365, ZNF652 ENSG00000198740 Zinc finger protein 652 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2D9] 6.98 5.81 -1.17 -2.24 2.02E-06 4.38E-05 6.62E-11 1.80E-09 1.19 4 hsa-miR-132,hsa-miR-155,hsa-miR-200b,hsa-miR-206, Butyrate response factor 2 (Protein TIS11D)(EGF-response factor ZFP36L2 ENSG00000152518 2)(ERF-2) [Source:UniProtKB/Swiss-Prot;Acc:P47974] 9.57 8.40 -1.17 -2.24 3.17E-04 2.66E-03 7.78E-08 9.50E-07 1.70 1 hsa-miR-155, Endoplasmic reticulum resident protein ERp27 Precursor ERP27 ENSG00000139055 [Source:UniProtKB/Swiss-Prot;Acc:Q96DN0] 6.64 5.49 -1.16 -2.23 3.73E-06 7.16E-05 1.91E-10 4.56E-09 1.21 1 hsa-miR-218, hsa-miR-19b,hsa-miR-200b,hsa-miR-206,hsa-miR-20a,hsa-miR-21,hsa-miR-24,hsa- FAM46C ENSG00000183508 Protein FAM46C [Source:UniProtKB/Swiss-Prot;Acc:Q5VWP2] 9.16 8.01 -1.15 -2.21 3.67E-05 4.52E-04 4.86E-10 1.04E-08 1.79 7 miR-7, Neuroblast differentiation-associated protein AHNAK (Desmoyokin) AHNAK ENSG00000124942 [Source:UniProtKB/Swiss-Prot;Acc:Q09666] 9.64 8.50 -1.14 -2.21 4.59E-05 5.45E-04 9.17E-10 1.80E-08 2.14 2 hsa-miR-200b,hsa-miR-7, B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein)(BCL9-like protein)(Protein BCL9-2) BCL9L ENSG00000186174 [Source:UniProtKB/Swiss-Prot;Acc:Q86UU0] 7.76 6.63 -1.13 -2.19 7.89E-08 3.11E-06 4.90E-13 2.42E-11 1.13 1 hsa-miR-29b, Transmembrane protein 63A [Source:UniProtKB/Swiss- TMEM63A ENSG00000196187 Prot;Acc:O94886] 8.09 7.01 -1.08 -2.12 4.25E-04 3.38E-03 8.32E-09 1.27E-07 1.55 1 hsa-miR-21, Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6)(MAPKK 6)(EC 2.7.12.2)(MAPK/ERK kinase 6)(SAPKK3) MAP2K6 ENSG00000108984 [Source:UniProtKB/Swiss-Prot;Acc:P52564] 6.96 5.88 -1.08 -2.12 3.95E-04 3.18E-03 2.58E-10 5.94E-09 1.77 1 hsa-miR-29b, Multiple epidermal growth factor-like domains 9 Precursor (EGF-like domain-containing protein 5)(Multiple EGF-like domain protein 5) MEGF9 ENSG00000106780 [Source:UniProtKB/Swiss-Prot;Acc:Q9H1U4] 7.12 6.03 -1.08 -2.12 1.06E-05 1.66E-04 1.65E-07 1.86E-06 1.08 4 hsa-miR-21,hsa-miR-218,hsa-miR-222,hsa-miR-7, cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17)(DPDE4)(PDE32) [Source:UniProtKB/Swiss- PDE4B ENSG00000184588 Prot;Acc:Q07343] 8.21 7.13 -1.08 -2.11 1.21E-03 7.96E-03 1.32E-06 1.19E-05 1.59 3 hsa-miR-130b,hsa-miR-200b,hsa-miR-7, Tribbles homolog 2 (TRB-2) [Source:UniProtKB/Swiss- TRIB2 ENSG00000071575 Prot;Acc:Q92519] 7.26 6.19 -1.07 -2.10 1.39E-04 1.36E-03 5.35E-09 8.52E-08 1.56 3 hsa-miR-132,hsa-miR-18a,hsa-miR-7, Proto-oncogene tyrosine-protein kinase FGR (C-FGR)(EC FGR ENSG00000000938 2.7.10.2)(P55-FGR) [Source:UniProtKB/Swiss-Prot;Acc:P09769] 7.27 6.20 -1.07 -2.09 1.92E-06 4.20E-05 3.82E-11 1.11E-09 1.14 1 hsa-miR-7, Dual specificity protein phosphatase 8 (EC 3.1.3.48)(EC 3.1.3.16)(Dual specificity protein phosphatase hVH-5) DUSP8 ENSG00000184545 [Source:UniProtKB/Swiss-Prot;Acc:Q13202] 7.66 6.61 -1.05 -2.06 6.36E-06 1.09E-04 1.81E-11 5.71E-10 1.29 2 hsa-miR-21,hsa-miR-24, Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) [Source:UniProtKB/Swiss- PBXIP1 ENSG00000163346 Prot;Acc:Q96AQ6] 7.85 6.82 -1.03 -2.05 6.20E-08 2.57E-06 5.47E-14 3.64E-12 1.16 1 hsa-miR-24, CCNL1 ENSG00000163660 Cyclin-L1 (Cyclin-L) [Source:UniProtKB/Swiss-Prot;Acc:Q9UK58] 9.08 8.05 -1.03 -2.04 8.82E-04 6.17E-03 5.57E-06 4.35E-05 1.32 1 hsa-miR-19a, Transcription factor PU.1 (31 kDa-transforming protein) SPI1 ENSG00000066336 [Source:UniProtKB/Swiss-Prot;Acc:P17947] 6.42 5.39 -1.02 -2.03 8.05E-05 8.63E-04 6.71E-06 5.14E-05 1.02 1 hsa-miR-155, Leptin receptor overlapping transcript-like 1 LEPROTL1 ENSG00000104660 [Source:UniProtKB/Swiss-Prot;Acc:O95214] 9.23 8.21 -1.02 -2.03 1.63E-06 3.67E-05 8.92E-09 1.36E-07 1.15 2 hsa-miR-155,hsa-miR-210, Protein FAM102A (Early estrogen-induced gene 1 protein) FAM102A ENSG00000167106 [Source:UniProtKB/Swiss-Prot;Acc:Q5T9C2] 8.00 6.99 -1.01 -2.01 3.36E-05 4.22E-04 5.46E-09 8.68E-08 1.13 3 hsa-miR-106b,hsa-miR-19a,hsa-miR-27a, Tumor protein p53-inducible nuclear protein 2 (p53-inducible protein TP53INP2 ENSG00000078804 U)(PIG-U) [Source:UniProtKB/Swiss-Prot;Acc:Q8IXH6] 6.87 5.87 -1.00 -1.99 7.12E-06 1.20E-04 7.83E-08 9.55E-07 1.06 5 hsa-miR-18a,hsa-miR-222,hsa-miR-29b,hsa-miR-365,hsa-miR-7, fMet-Leu-Phe receptor (fMLP receptor)(N-formyl peptide receptor)(FPR)(N-formylpeptide chemoattractant receptor) FPR1 ENSG00000171051 [Source:UniProtKB/Swiss-Prot;Acc:P21462] 6.82 5.83 -0.99 -1.99 2.76E-04 2.37E-03 1.05E-05 7.75E-05 1.12 1 hsa-miR-24, Transcription factor 7 (T-cell-specific transcription factor 1)(T-cell TCF7 ENSG00000081059 factor 1)(TCF-1) [Source:UniProtKB/Swiss-Prot;Acc:P36402] 7.87 6.88 -0.99 -1.98 1.99E-04 1.82E-03 1.94E-08 2.72E-07 1.20 1 hsa-miR-24, Zinc finger protein 238 (Transcriptional repressor RP58)(58 kDa repressor protein)(Zinc finger protein C2H2-171)(Translin- associated zinc finger protein 1)(TAZ-1)(Zinc finger and BTB domain- ZNF238 ENSG00000179456 containing protein 18) [Source:UniProtKB/Swiss-Prot;Acc:Q99592] 6.52 5.55 -0.98 -1.97 9.59E-07 2.35E-05 7.04E-08 8.70E-07 0.99 3 hsa-miR-155,hsa-miR-19a,hsa-miR-27a, Transducin-like enhancer protein 4 [Source:UniProtKB/Swiss- TLE4 ENSG00000106829 Prot;Acc:Q04727] 6.82 5.84 -0.97 -1.96 8.30E-05 8.84E-04 3.46E-07 3.57E-06 1.11 2 hsa-miR-155,hsa-miR-424, Tetraspanin-32 (Tspan-32)(Protein Phemx) [Source:UniProtKB/Swiss- TSPAN32 ENSG00000064201 Prot;Acc:Q96QS1] 7.64 6.68 -0.96 -1.94 7.23E-08 2.89E-06 8.18E-14 5.20E-12 0.96 1 hsa-miR-155, Ras-related protein Rab-37 [Source:UniProtKB/Swiss- RAB37 ENSG00000172794 Prot;Acc:Q96AX2] 6.85 5.90 -0.95 -1.94 1.77E-09 1.39E-07 8.63E-14 5.44E-12 0.95 1 hsa-miR-24, Prostaglandin E2 receptor EP4 subtype (PGE receptor, EP4 subtype)(Prostanoid EP4 receptor) [Source:UniProtKB/Swiss- PTGER4 ENSG00000171522 Prot;Acc:P35408] 9.28 8.34 -0.94 -1.92 5.96E-04 4.47E-03 7.71E-08 9.43E-07 1.51 1 hsa-miR-24, Inositol-trisphosphate 3-kinase B (EC 2.7.1.127)(Inositol 1,4,5- trisphosphate 3-kinase B)(IP3 3-kinase B)(IP3K-B)(IP3K B) ITPKB ENSG00000143772 [Source:UniProtKB/Swiss-Prot;Acc:P27987] 7.45 6.53 -0.92 -1.90 1.15E-03 7.59E-03 1.53E-06 1.36E-05 1.15 2 hsa-miR-19a,hsa-miR-7, Transcription factor MafB (Maf-B)(V-maf musculoaponeurotic fibrosarcoma oncogene homolog B) [Source:UniProtKB/Swiss- MAFB ENSG00000204103 Prot;Acc:Q9Y5Q3] 6.00 5.09 -0.91 -1.88 4.74E-05 5.58E-04 5.70E-07 5.59E-06 0.91 3 hsa-miR-155,hsa-miR-29b,hsa-miR-365, Tumor necrosis factor, alpha-induced protein 3 (EC 3.-.-.-)(Putative DNA-binding protein A20)(Zinc finger protein A20) TNFAIP3 ENSG00000118503 [Source:UniProtKB/Swiss-Prot;Acc:P21580] 10.70 9.79 -0.91 -1.88 2.80E-04 2.40E-03 4.53E-09 7.37E-08 1.49 2 hsa-miR-18a,hsa-miR-19a, [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial Precursor (PDP 1)(EC 3.1.3.43)(Pyruvate dehydrogenase phosphatase, catalytic subunit 1)(PDPC 1)(Protein PPM2C ENSG00000164951 phosphatase 2C) [Source:UniProtKB/Swiss-Prot;Acc:Q9P0J1] 7.88 6.98 -0.91 -1.87 1.54E-05 2.25E-04 8.81E-10 1.73E-08 1.20 1 hsa-miR-132,

RNF166 ENSG00000158717 RING finger protein 166 [Source:UniProtKB/Swiss-Prot;Acc:Q96A37] 8.19 7.29 -0.89 -1.86 1.20E-04 1.19E-03 4.84E-08 6.19E-07 1.20 1 hsa-miR-155, Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein)(Neuronal Munc18-1-interacting protein 2)(Mint- 2)(Adapter protein X11beta) [Source:UniProtKB/Swiss- APBA2 ENSG00000034053 Prot;Acc:Q99767] 6.89 6.01 -0.88 -1.85 2.50E-04 2.19E-03 6.40E-08 7.99E-07 1.14 2 hsa-miR-210,hsa-miR-27a, Inactive phospholipase C-like protein 2 (Phospholipase C-L2)(PLC- L(2))(PLC-L2)(Phospholipase C epsilon 2) [Source:UniProtKB/Swiss- PLCL2 ENSG00000154822 Prot;Acc:Q9UPR0] 7.72 6.86 -0.87 -1.82 1.17E-03 7.71E-03 3.67E-05 2.38E-04 1.08 5 hsa-miR-19a,hsa-miR-218,hsa-miR-221,hsa-miR-24,hsa-miR-27a, Modulator of apoptosis 1 (MAP-1)(MAP1)(Paraneoplastic antigen MOAP1 ENSG00000165943 Ma4) [Source:UniProtKB/Swiss-Prot;Acc:Q96BY2] 7.51 6.65 -0.86 -1.82 6.96E-06 1.18E-04 4.34E-08 5.60E-07 0.92 1 hsa-miR-21, Interferon regulatory factor 1 (IRF-1) [Source:UniProtKB/Swiss- IRF1 ENSG00000125347 Prot;Acc:P10914] 7.93 7.07 -0.86 -1.82 9.27E-04 6.42E-03 1.45E-04 8.15E-04 0.86 1 hsa-miR-24, Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) TSPYL1 ENSG00000189241 [Source:UniProtKB/Swiss-Prot;Acc:Q9H0U9] 8.90 8.04 -0.86 -1.81 9.64E-05 1.00E-03 3.50E-07 3.61E-06 0.87 2 hsa-miR-18a,hsa-miR-7, Integral membrane protein 2B (Transmembrane protein BRI) [Contains ABri/ADan amyloid peptide] [Source:UniProtKB/Swiss- ITM2B ENSG00000136156 Prot;Acc:Q9Y287] 10.16 9.33 -0.83 -1.78 6.05E-04 4.52E-03 1.06E-05 7.81E-05 1.26 1 hsa-miR-18a, Protein unc-84 homolog B (Sad1/unc-84 protein-like 2)(Rab5- interacting protein)(Rab5IP) [Source:UniProtKB/Swiss- UNC84B ENSG00000100242 Prot;Acc:Q9UH99] 8.13 7.31 -0.82 -1.77 1.79E-04 1.67E-03 6.39E-10 1.32E-08 1.30 1 hsa-miR-222, Midnolin (Midbrain nucleolar protein) [Source:UniProtKB/Swiss- MIDN ENSG00000167470 Prot;Acc:Q504T8] 7.11 6.29 -0.82 -1.76 4.68E-07 1.31E-05 3.20E-08 4.26E-07 0.82 5 hsa-miR-155,hsa-miR-221,hsa-miR-24,hsa-miR-27a,hsa-miR-7, Midnolin (Midbrain nucleolar protein) [Source:UniProtKB/Swiss- MIDN ENSG00000167470 Prot;Acc:Q504T8] 7.11 6.29 -0.82 -1.76 4.68E-07 1.31E-05 3.20E-08 4.26E-07 0.82 5 hsa-miR-155,hsa-miR-221,hsa-miR-24,hsa-miR-27a,hsa-miR-7, SID1 transmembrane family member 1 Precursor SIDT1 ENSG00000072858 [Source:UniProtKB/Swiss-Prot;Acc:Q9NXL6] 7.30 6.48 -0.82 -1.76 1.14E-03 7.57E-03 4.41E-06 3.54E-05 1.12 2 hsa-miR-18a,hsa-miR-424, Ly6/PLAUR domain-containing protein 3 Precursor (GPI-anchored metastasis-associated protein C4.4A homolog)(Matrigel-induced gene C4 protein)(MIG-C4) [Source:UniProtKB/Swiss- LYPD3 ENSG00000124466 Prot;Acc:O95274] 7.47 6.65 -0.82 -1.76 2.03E-05 2.82E-04 4.65E-09 7.53E-08 0.92 2 hsa-miR-27a,hsa-miR-7, Cell surface A33 antigen Precursor (Glycoprotein A33) GPA33 ENSG00000143167 [Source:UniProtKB/Swiss-Prot;Acc:Q99795] 6.59 5.78 -0.81 -1.76 1.89E-05 2.66E-04 1.15E-08 1.70E-07 0.87 1 hsa-miR-19a, Z-DNA-binding protein 1 (Tumor stroma and activated macrophage ZBP1 ENSG00000124256 protein DLM-1) [Source:UniProtKB/Swiss-Prot;Acc:Q9H171] 6.58 5.77 -0.81 -1.76 6.56E-07 1.73E-05 5.09E-09 8.17E-08 0.81 1 hsa-miR-424, Leukocyte-associated immunoglobulin-like receptor 1 Precursor (LAIR- 1)(hLAIR1)(CD305 antigen) [Source:UniProtKB/Swiss- LAIR1 ENSG00000167613 Prot;Acc:Q6GTX8] 7.05 6.25 -0.80 -1.74 4.15E-05 4.99E-04 9.23E-08 1.11E-06 0.85 1 hsa-miR-210, Toll-like receptor 4 Precursor (hToll)(CD284 antigen) TLR4 ENSG00000136869 [Source:UniProtKB/Swiss-Prot;Acc:O00206] 6.49 5.69 -0.80 -1.74 2.21E-04 1.98E-03 4.35E-06 3.49E-05 0.83 1 hsa-miR-18a, Vacuolar protein sorting-associated protein 37B (hVps37B)(ESCRT-I complex subunit VPS37B) [Source:UniProtKB/Swiss- VPS37B ENSG00000139722 Prot;Acc:Q9H9H4] 7.66 6.86 -0.80 -1.74 3.27E-05 4.13E-04 6.82E-07 6.55E-06 0.85 1 hsa-miR-19a, Protein BTG2 (BTG family member 2)(NGF-inducible anti- BTG2 ENSG00000159388 proliferative protein PC3) [Source:UniProtKB/Swiss-Prot;Acc:P78543] 8.76 7.96 -0.80 -1.74 1.43E-03 9.05E-03 8.66E-05 5.15E-04 0.98 5 hsa-miR-132,hsa-miR-18a,hsa-miR-218,hsa-miR-27a,hsa-miR-365, Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor)(p114-Rho- GEF)(p114RhoGEF)(Septin-associated RhoGEF)(SA-RhoGEF) ARHGEF18 ENSG00000104880 [Source:UniProtKB/Swiss-Prot;Acc:Q6ZSZ5] 7.38 6.59 -0.79 -1.73 1.66E-04 1.57E-03 2.26E-07 2.46E-06 0.93 1 hsa-miR-20a, Krueppel-like factor 4 (Epithelial zinc finger protein EZF)(Gut- enriched krueppel-like factor) [Source:UniProtKB/Swiss- KLF4 ENSG00000136826 Prot;Acc:O43474] 6.30 5.51 -0.78 -1.72 3.95E-05 4.80E-04 2.31E-07 2.50E-06 0.80 1 hsa-miR-7, Inactive phospholipase C-like protein 1 (PLC-L1)(Phospholipase C- deleted in lung carcinoma)(Phospholipase C-related but catalytically PLCL1 ENSG00000115896 inactive protein)(PRIP) [Source:UniProtKB/Swiss-Prot;Acc:Q15111] 7.17 6.39 -0.78 -1.72 1.40E-04 1.37E-03 1.09E-08 1.62E-07 1.17 2 hsa-miR-19a,hsa-miR-7, Max-interacting transcriptional repressor MAD4 (Max-associated protein 4)(MAX dimerization protein 4) [Source:UniProtKB/Swiss- MXD4 ENSG00000123933 Prot;Acc:Q14582] 6.94 6.16 -0.78 -1.71 5.02E-07 1.39E-05 9.14E-12 3.13E-10 0.82 4 hsa-miR-18a,hsa-miR-200b,hsa-miR-206,hsa-miR-210, Coiled-coil domain-containing protein 65 (Testis development protein CCDC65 ENSG00000139537 NYD-SP28) [Source:UniProtKB/Swiss-Prot;Acc:Q8IXS2] 6.65 5.89 -0.77 -1.70 3.76E-05 4.60E-04 3.68E-09 6.12E-08 0.94 1 hsa-miR-7, EF-hand domain-containing protein D2 (Swiprosin-1) EFHD2 ENSG00000142634 [Source:UniProtKB/Swiss-Prot;Acc:Q96C19] 7.64 6.88 -0.76 -1.70 2.47E-04 2.17E-03 4.29E-07 4.33E-06 0.80 2 hsa-let-7f,hsa-miR-7, Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC DYRK2 ENSG00000127334 2.7.12.1) [Source:UniProtKB/Swiss-Prot;Acc:Q92630] 8.24 7.48 -0.76 -1.69 2.71E-06 5.56E-05 5.13E-12 1.88E-10 0.93 4 hsa-miR-200b,hsa-miR-24,hsa-miR-365,hsa-miR-7, MYO1F ENSG00000142347 Myosin-If (Myosin-Ie) [Source:UniProtKB/Swiss-Prot;Acc:O00160] 7.00 6.25 -0.76 -1.69 1.16E-03 7.65E-03 3.27E-05 2.14E-04 0.76 1 hsa-miR-7, Disrupted in renal carcinoma protein 2 (Disrupted in renal cancer DIRC2 ENSG00000138463 protein 2) [Source:UniProtKB/Swiss-Prot;Acc:Q96SL1] 7.40 6.65 -0.75 -1.68 2.83E-07 8.75E-06 7.38E-08 9.07E-07 0.75 1 hsa-miR-19a, Solute carrier family 40 member 1 (Ferroportin-1)(Iron-regulated SLC40A1 ENSG00000138449 transporter 1) [Source:UniProtKB/Swiss-Prot;Acc:Q9NP59] 7.08 6.33 -0.75 -1.68 9.84E-04 6.70E-03 8.75E-06 6.56E-05 0.81 2 hsa-miR-20b,hsa-miR-221, Lysosome membrane protein 2 (Lysosome membrane protein II)(LIMP II)(Scavenger receptor class B member 2)(85 kDa lysosomal membrane sialoglycoprotein)(LGP85)(CD36 antigen-like 2)(CD36 SCARB2 ENSG00000138760 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q14108] 6.59 5.85 -0.73 -1.66 2.53E-04 2.20E-03 1.61E-07 1.82E-06 0.97 2 hsa-miR-221,hsa-miR-365, Low affinity immunoglobulin gamma Fc region receptor III-A Precursor (IgG Fc receptor III-2)(Fc-gamma RIII-alpha)(Fc-gamma RIIIa)(FcRIIIa)(Fc-gamma RIII)(FcRIII)(FcR-10)(CD16a FCGR3A ENSG00000203747 antigen)(CD16a antigen) [Source:UniProtKB/Swiss-Prot;Acc:P08637] 7.02 6.29 -0.73 -1.66 1.31E-03 8.44E-03 7.21E-03 2.49E-02 0.73 1 hsa-miR-7, C-type lectin domain family 7 member A (Dendritic cell-associated C- type lectin 1)(DC-associated C-type lectin 1)(Dectin-1)(Beta-glucan receptor)(C-type lectin superfamily member 12) CLEC7A ENSG00000172243 [Source:UniProtKB/Swiss-Prot;Acc:Q9BXN2] 6.78 6.05 -0.73 -1.66 3.51E-06 6.86E-05 1.21E-08 1.79E-07 0.73 1 hsa-miR-200b, Centrosomal protein of 68 kDa (Cep68) [Source:UniProtKB/Swiss- CEP68 ENSG00000011523 Prot;Acc:Q76N32] 7.03 6.30 -0.73 -1.66 1.39E-06 3.23E-05 1.01E-10 2.61E-09 0.80 6 hsa-miR-155,hsa-miR-21,hsa-miR-218,hsa-miR-27a,hsa-miR-29b,hsa-miR-424, Beta-2 adrenergic receptor (Beta-2 adrenoreceptor)(Beta-2 ADRB2 ENSG00000169252 adrenoceptor) [Source:UniProtKB/Swiss-Prot;Acc:P07550] 7.21 6.48 -0.73 -1.66 1.29E-05 1.94E-04 5.77E-07 5.65E-06 1.00 2 hsa-miR-200b,hsa-miR-27a, Interleukin-6 receptor subunit alpha Precursor (IL-6R-alpha)(IL-6R 1)(Membrane glycoprotein 80)(gp80)(CD126 antigen) IL6R ENSG00000160712 [Source:UniProtKB/Swiss-Prot;Acc:P08887] 7.08 6.35 -0.73 -1.65 1.55E-03 9.64E-03 1.41E-05 1.01E-04 0.99 1 hsa-miR-7, Tetraspanin-14 (Tspan-14)(Transmembrane 4 superfamily member TSPAN14 ENSG00000108219 14)(DC-TM4F2) [Source:UniProtKB/Swiss-Prot;Acc:Q8NG11] 8.21 7.50 -0.71 -1.64 1.30E-03 8.40E-03 2.94E-05 1.95E-04 0.84 2 hsa-miR-155,hsa-miR-24, Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein)(H-l(3)mbt-like protein) [Source:UniProtKB/Swiss- L3MBTL3 ENSG00000198945 Prot;Acc:Q96JM7] 7.20 6.49 -0.71 -1.63 1.53E-03 9.55E-03 1.41E-04 8.00E-04 0.71 4 hsa-miR-132,hsa-miR-19a,hsa-miR-218,hsa-miR-222, Autism susceptibility gene 2 protein [Source:UniProtKB/Swiss- AUTS2 ENSG00000158321 Prot;Acc:Q8WXX7] 6.88 6.17 -0.71 -1.63 3.55E-07 1.04E-05 1.21E-10 3.05E-09 0.74 1 hsa-miR-200b,

Pleckstrin homology domain-containing family M member 1 (162 kDa PLEKHM1 ENSG00000225190 adapter protein)(AP162) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y4G2] 7.54 6.84 -0.71 -1.63 5.24E-06 9.38E-05 2.41E-07 2.60E-06 0.71 2 hsa-miR-106b,hsa-miR-206, Plexin domain-containing protein 1 Precursor (Tumor endothelial marker 7)(Tumor endothelial marker 3) [Source:UniProtKB/Swiss- PLXDC1 ENSG00000161381 Prot;Acc:Q8IUK5] 7.09 6.39 -0.69 -1.62 1.21E-06 2.87E-05 2.96E-11 8.79E-10 0.73 1 hsa-miR-155, SNN ENSG00000184602 Stannin (AG8_1) [Source:UniProtKB/Swiss-Prot;Acc:O75324] 7.63 6.95 -0.68 -1.60 2.29E-05 3.10E-04 7.06E-07 6.75E-06 0.68 2 hsa-miR-24,hsa-miR-27a, Protein NLRC5 (Nucleotide-binding oligomerization domain protein 4)(Nucleotide-binding oligomerization domain protein 27)(Protein Caterpiller 16.1)(CLR16.1) [Source:UniProtKB/Swiss- NLRC5 ENSG00000140853 Prot;Acc:Q86WI3] 7.69 7.01 -0.67 -1.59 1.09E-03 7.30E-03 7.71E-06 5.84E-05 0.71 1 hsa-miR-7, Neuronal cell adhesion molecule Precursor (Nr-CAM)(NgCAM- related cell adhesion molecule)(Ng-CAM-related)(hBravo) NRCAM ENSG00000091129 [Source:UniProtKB/Swiss-Prot;Acc:Q92823] 6.91 6.24 -0.67 -1.59 5.67E-05 6.47E-04 1.11E-05 8.14E-05 0.67 4 hsa-miR-21,hsa-miR-218,hsa-miR-27a,hsa-miR-7, Sphingosine 1-phosphate receptor 5 (S1P receptor 5)(S1P5)(Sphingosine 1-phosphate receptor Edg-8)(S1P receptor Edg-8)(Endothelial differentiation G-protein-coupled receptor 8) S1PR5 ENSG00000180739 [Source:UniProtKB/Swiss-Prot;Acc:Q9H228] 7.38 6.72 -0.67 -1.59 2.35E-08 1.18E-06 7.78E-12 2.73E-10 0.69 1 hsa-miR-7, Protein Jade-2 (PHD finger protein 15) [Source:UniProtKB/Swiss- PHF15 ENSG00000043143 Prot;Acc:Q9NQC1] 7.34 6.67 -0.66 -1.58 4.65E-04 3.64E-03 1.69E-03 7.27E-03 0.66 4 hsa-miR-19b,hsa-miR-218,hsa-miR-365,hsa-miR-7, Stathmin-3 (SCG10-like protein) [Source:UniProtKB/Swiss- STMN3 ENSG00000197457 Prot;Acc:Q9NZ72] 6.98 6.33 -0.65 -1.57 1.24E-06 2.92E-05 8.22E-09 1.26E-07 0.65 1 hsa-miR-24, Platelet-derived growth factor D Precursor (PDGF-D)(Iris-expressed growth factor)(Spinal cord-derived growth factor B)(SCDGF-B) [Contains Platelet-derived growth factor D, latent form(PDGFD latent PDGFD ENSG00000170962 form);Platelet-derived growth factor D, receptor-binding f 4.04 3.39 -0.65 -1.57 3.33E-04 2.77E-03 3.71E-04 1.91E-03 0.67 1 hsa-miR-221, Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3)(Ca(v)3.3) CACNA1I ENSG00000100346 [Source:UniProtKB/Swiss-Prot;Acc:Q9P0X4] 6.97 6.33 -0.65 -1.57 3.11E-08 1.46E-06 2.97E-13 1.57E-11 0.69 3 hsa-miR-218,hsa-miR-363,hsa-miR-7, A disintegrin and metalloproteinase with thrombospondin motifs 10 Precursor (ADAMTS-10)(ADAM-TS 10)(ADAM-TS10)(EC 3.4.24.-) ADAMTS10 ENSG00000142303 [Source:UniProtKB/Swiss-Prot;Acc:Q9H324] 6.70 6.07 -0.64 -1.55 1.04E-06 2.52E-05 7.40E-10 1.50E-08 0.67 1 hsa-miR-27a, Metalloproteinase inhibitor 2 Precursor (Tissue inhibitor of metalloproteinases 2)(TIMP-2)(CSC-21K) [Source:UniProtKB/Swiss- TIMP2 ENSG00000035862 Prot;Acc:P16035] 6.54 5.91 -0.63 -1.55 3.36E-05 4.22E-04 6.56E-06 5.04E-05 0.63 2 hsa-miR-18a,hsa-miR-221, Low affinity immunoglobulin gamma Fc region receptor II-b Precursor (IgG Fc receptor II-b)(Fc-gamma RII-b)(Fc-gamma-RIIb)(FcRII- b)(CDw32)(CD32 antigen) [Source:UniProtKB/Swiss- FCGR2B ENSG00000072694 Prot;Acc:P31994] 7.06 6.43 -0.62 -1.54 4.04E-05 4.89E-04 6.97E-07 6.68E-06 0.63 1 hsa-miR-7, Zinc transporter 4 (ZnT-4)(Solute carrier family 30 member 4) SLC30A4 ENSG00000104154 [Source:UniProtKB/Swiss-Prot;Acc:O14863] 6.47 5.86 -0.61 -1.53 5.35E-04 4.09E-03 1.22E-04 6.99E-04 0.61 1 hsa-miR-7, Nucleosome assembly protein 1-like 5 [Source:UniProtKB/Swiss- NAP1L5 ENSG00000177432 Prot;Acc:Q96NT1] 7.45 6.85 -0.60 -1.51 1.68E-05 2.41E-04 8.97E-08 1.08E-06 0.72 3 hsa-miR-200b,hsa-miR-222,hsa-miR-27a, LIM domain-containing protein 2 [Source:UniProtKB/Swiss- LIMD2 ENSG00000136490 Prot;Acc:Q9BT23] 7.65 7.06 -0.59 -1.51 2.06E-04 1.88E-03 1.02E-05 7.55E-05 0.59 2 hsa-miR-19a,hsa-miR-24, Transmembrane protein C2orf18 Precursor C2orf18 ENSG00000213699 [Source:UniProtKB/Swiss-Prot;Acc:Q8N357] 8.11 7.53 -0.59 -1.50 7.45E-07 1.93E-05 3.16E-08 4.22E-07 0.59 1 hsa-miR-155, Cathepsin K Precursor (EC 3.4.22.38)(Cathepsin O)(Cathepsin CTSK ENSG00000143387 X)(Cathepsin O2) [Source:UniProtKB/Swiss-Prot;Acc:P43235] 6.05 5.47 -0.58 -1.49 1.95E-04 1.79E-03 4.91E-05 3.10E-04 0.58 1 hsa-miR-7, Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3)(Long-chain acyl- CoA synthetase 6)(LACS 6) [Source:UniProtKB/Swiss- ACSL6 ENSG00000164398 Prot;Acc:Q9UKU0] 7.06 6.49 -0.57 -1.49 9.52E-04 6.54E-03 1.74E-06 1.53E-05 0.92 1 hsa-miR-24, SLAM family member 5 Precursor (Signaling lymphocytic activation molecule 5)(Leukocyte differentiation antigen CD84)(Cell surface antigen MAX.3)(Hly9-beta)(CD84 antigen) [Source:UniProtKB/Swiss- CD84 ENSG00000066294 Prot;Acc:Q9UIB8] 6.92 6.35 -0.57 -1.49 1.22E-03 8.00E-03 5.98E-09 9.44E-08 1.01 1 hsa-miR-155,

Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter)(Na(+)/HCO3(-) cotransporter)(Solute carrier family 4 SLC4A4 ENSG00000080493 member 4)(kNBC1) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y6R1] 7.43 6.86 -0.57 -1.49 1.20E-04 1.20E-03 1.25E-05 9.07E-05 0.57 4 hsa-miR-200b,hsa-miR-210,hsa-miR-222,hsa-miR-7, Protein Wnt-7a Precursor [Source:UniProtKB/Swiss- WNT7A ENSG00000154764 Prot;Acc:O00755] 6.29 5.73 -0.55 -1.47 5.89E-05 6.69E-04 1.35E-06 1.21E-05 0.56 1 hsa-miR-7, Vasoactive intestinal polypeptide receptor 1 Precursor (VIP-R- 1)(Pituitary adenylate cyclase-activating polypeptide type II receptor)(PACAP type II receptor)(PACAP-R-2) VIPR1 ENSG00000114812 [Source:UniProtKB/Swiss-Prot;Acc:P32241] 7.09 6.54 -0.55 -1.47 8.56E-08 3.31E-06 7.22E-11 1.94E-09 0.55 1 hsa-miR-155, EF-hand domain-containing family member C2 EFHC2 ENSG00000183690 [Source:UniProtKB/Swiss-Prot;Acc:Q5JST6] 6.29 5.74 -0.55 -1.47 4.06E-04 3.25E-03 1.01E-04 5.88E-04 0.70 1 hsa-miR-222, Iduronate 2-sulfatase Precursor (EC 3.1.6.13)(Alpha-L-iduronate sulfate sulfatase)(Idursulfase) [Contains Iduronate 2-sulfatase 42 kDa chain;Iduronate 2-sulfatase 14 kDa chain] [Source:UniProtKB/Swiss- IDS ENSG00000010404 Prot;Acc:P22304] 7.61 7.06 -0.55 -1.47 5.62E-05 6.43E-04 4.14E-08 5.37E-07 0.73 1 hsa-miR-7, Disrupted in schizophrenia 1 protein [Source:UniProtKB/Swiss- DISC1 ENSG00000162946 Prot;Acc:Q9NRI5] 6.92 6.37 -0.55 -1.46 4.91E-07 1.36E-05 2.78E-10 6.34E-09 0.55 1 hsa-miR-24, P2Y purinoceptor 13 (P2Y13)(G-protein coupled receptor 86)(G- protein coupled receptor 94) [Source:UniProtKB/Swiss- P2RY13 ENSG00000181631 Prot;Acc:Q9BPV8] 3.72 3.18 -0.55 -1.46 4.13E-05 4.97E-04 1.41E-06 1.26E-05 0.60 2 hsa-miR-18a,hsa-miR-7, Tubby-related protein 4 (Tubby-like protein 4)(Tubby superfamily TULP4 ENSG00000130338 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9NRJ4] 6.55 6.01 -0.54 -1.45 8.05E-08 3.15E-06 1.21E-09 2.29E-08 0.54 3 hsa-miR-132,hsa-miR-155,hsa-miR-7, Protein pellino homolog 2 (Pellino-2) [Source:UniProtKB/Swiss- PELI2 ENSG00000139946 Prot;Acc:Q9HAT8] 6.81 6.27 -0.54 -1.45 7.77E-05 8.40E-04 3.82E-09 6.32E-08 0.76 2 hsa-miR-200b,hsa-miR-27a, Acetylcholinesterase collagenic tail peptide Precursor (AChE Q subunit)(Acetylcholinesterase-associated collagen) COLQ ENSG00000206561 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y215] 6.76 6.23 -0.53 -1.45 3.35E-06 6.60E-05 2.72E-07 2.90E-06 0.53 2 hsa-miR-132,hsa-miR-27a, Sushi domain-containing protein 1 Precursor SUSD1 ENSG00000106868 [Source:UniProtKB/Swiss-Prot;Acc:Q6UWL2] 6.59 6.06 -0.53 -1.44 3.76E-07 1.10E-05 8.35E-10 1.67E-08 0.53 1 hsa-miR-7, Urea transporter, erythrocyte [Source:UniProtKB/Swiss- SLC14A1 ENSG00000141469 Prot;Acc:Q13336] 5.96 5.44 -0.52 -1.44 1.82E-04 1.69E-03 5.52E-07 5.44E-06 0.86 1 hsa-miR-200b, RNF44 ENSG00000146083 RING finger protein 44 [Source:UniProtKB/Swiss-Prot;Acc:Q7L0R7] 7.48 6.96 -0.52 -1.43 9.31E-05 9.71E-04 1.62E-06 1.43E-05 0.63 3 hsa-miR-19a,hsa-miR-221,hsa-miR-365, Gamma-aminobutyric acid type B receptor subunit 1 Precursor (GABA- B receptor 1)(GABA-B-R1)(Gb1) [Source:UniProtKB/Swiss- GABBR1 ENSG00000204681 Prot;Acc:Q9UBS5] 6.89 6.39 -0.51 -1.42 2.31E-06 4.86E-05 1.89E-08 2.66E-07 0.53 2 hsa-miR-424,hsa-miR-7, GSK-3-binding protein FRAT2 (Frat-2) [Source:UniProtKB/Swiss- FRAT2 ENSG00000181274 Prot;Acc:O75474] 7.13 6.62 -0.50 -1.42 2.44E-04 2.15E-03 9.14E-06 6.81E-05 0.66 1 hsa-miR-221, FRY ENSG00000073910 Protein furry homolog [Source:UniProtKB/Swiss-Prot;Acc:Q5TBA9] 7.03 6.53 -0.50 -1.41 1.54E-05 2.25E-04 6.27E-09 9.85E-08 0.64 2 hsa-miR-132,hsa-miR-221, Ataxin-7-like protein 1 (Ataxin-7-like protein 4) ATXN7L1 ENSG00000146776 [Source:UniProtKB/Swiss-Prot;Acc:Q9ULK2] 6.55 6.06 -0.49 -1.41 1.53E-04 1.46E-03 2.06E-09 3.67E-08 0.75 3 hsa-miR-130b,hsa-miR-19a,hsa-miR-7, C-C chemokine receptor type 9 (C-C CKR-9)(CC-CKR-9)(CCR- 9)(GPR-9-6)(G-protein coupled receptor 28)(CDw199 antigen) CCR9 ENSG00000173585 [Source:UniProtKB/Swiss-Prot;Acc:P51686] 6.63 6.14 -0.49 -1.40 2.93E-04 2.49E-03 1.99E-05 1.38E-04 0.64 1 hsa-miR-7, ALS2 C-terminal-like protein [Source:UniProtKB/Swiss- ALS2CL ENSG00000178038 Prot;Acc:Q60I27] 6.96 6.48 -0.48 -1.40 4.63E-06 8.50E-05 3.96E-08 5.16E-07 0.48 1 hsa-miR-24, YPEL1 ENSG00000100027 Protein yippee-like 1 [Source:UniProtKB/Swiss-Prot;Acc:O60688] 7.26 6.78 -0.48 -1.39 4.85E-05 5.69E-04 2.65E-09 4.59E-08 0.70 2 hsa-miR-20a,hsa-miR-7, Transmembrane protein C20orf108 [Source:UniProtKB/Swiss- C20orf108 ENSG00000124098 Prot;Acc:Q96KR6] 8.08 7.61 -0.48 -1.39 8.33E-05 8.86E-04 2.74E-05 1.82E-04 0.48 2 hsa-miR-155,hsa-miR-24, Tripartite motif-containing protein 62 [Source:UniProtKB/Swiss- TRIM62 ENSG00000116525 Prot;Acc:Q9BVG3] 6.56 6.08 -0.48 -1.39 2.89E-06 5.85E-05 2.33E-07 2.52E-06 0.48 1 hsa-miR-7, Sushi domain-containing protein 4 Precursor SUSD4 ENSG00000143502 [Source:UniProtKB/Swiss-Prot;Acc:Q5VX71] 7.15 6.67 -0.47 -1.39 4.15E-08 1.84E-06 1.50E-10 3.66E-09 0.49 1 hsa-miR-210,

Tyrosine-protein kinase BTK (EC 2.7.10.2)(Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase)(ATK)(B-cell BTK ENSG00000010671 progenitor kinase)(BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187] 6.17 5.69 -0.47 -1.39 1.00E-04 1.04E-03 2.03E-03 8.53E-03 0.56 1 hsa-miR-21, Axin-2 (Axis inhibition protein 2)(Conductin)(Axin-like protein)(Axil) AXIN2 ENSG00000168646 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2T1] 6.48 6.01 -0.47 -1.38 2.87E-05 3.71E-04 7.66E-07 7.28E-06 0.50 1 hsa-miR-222,

Tumor necrosis factor receptor superfamily member EDAR Precursor (Anhidrotic ectodysplasin receptor 1)(Ectodysplasin-A receptor)(EDA- A1 receptor)(Ectodermal dysplasia receptor)(Downless homolog) EDAR ENSG00000135960 [Source:UniProtKB/Swiss-Prot;Acc:Q9UNE0] 7.14 6.67 -0.47 -1.38 5.95E-06 1.04E-04 3.40E-07 3.52E-06 0.47 3 hsa-miR-24,hsa-miR-27a,hsa-miR-7, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A, subunit B, B-beta isoform)(PP2A, subunit B, B55- beta isoform)(PP2A, subunit B, PR55-beta isoform)(PP2A, subunit B, PPP2R2B ENSG00000156475 R2-beta isoform) [Source:UniProtKB/Swiss-Prot;Acc:Q0 8.05 7.58 -0.46 -1.38 5.23E-04 4.01E-03 1.37E-04 7.76E-04 0.46 1 hsa-miR-7, Xylosyltransferase 1 (EC 2.4.2.26)(Xylosyltransferase I)(XylT-I)(XT- I)(Peptide O-xylosyltransferase 1) [Source:UniProtKB/Swiss- XYLT1 ENSG00000103489 Prot;Acc:Q86Y38] 6.61 6.15 -0.46 -1.38 7.61E-05 8.26E-04 3.79E-09 6.28E-08 0.71 4 hsa-miR-18a,hsa-miR-19a,hsa-miR-24,hsa-miR-7, Myocyte-specific enhancer factor 2C [Source:UniProtKB/Swiss- MEF2C ENSG00000081189 Prot;Acc:Q06413] 6.49 6.03 -0.46 -1.37 9.50E-05 9.88E-04 6.62E-05 4.05E-04 0.46 3 hsa-miR-132,hsa-miR-19a,hsa-miR-27a, SNX29 ENSG00000048471 Sorting nexin-29 [Source:UniProtKB/Swiss-Prot;Acc:Q8TEQ0] 6.36 5.90 -0.46 -1.37 1.77E-05 2.51E-04 1.39E-08 2.02E-07 0.56 4 hsa-miR-155,hsa-miR-200b,hsa-miR-221,hsa-miR-7, SNX29 ENSG00000048471 Sorting nexin-29 [Source:UniProtKB/Swiss-Prot;Acc:Q8TEQ0] 6.36 5.90 -0.46 -1.37 1.77E-05 2.51E-04 1.39E-08 2.02E-07 0.56 4 hsa-miR-155,hsa-miR-200b,hsa-miR-221,hsa-miR-7, ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2)(ATP-binding cassette 2) [Source:UniProtKB/Swiss- ABCA2 ENSG00000107331 Prot;Acc:Q9BZC7] 7.00 6.54 -0.46 -1.37 1.78E-04 1.66E-03 6.18E-06 4.78E-05 0.46 1 hsa-miR-135b, WNT1-inducible-signaling pathway protein 1 Precursor (WISP- 1)(Wnt-1-induced secreted protein) [Source:UniProtKB/Swiss- WISP1 ENSG00000104415 Prot;Acc:O95388] 8.03 7.58 -0.45 -1.37 1.17E-03 7.72E-03 2.93E-04 1.54E-03 0.45 1 hsa-miR-29b, CRY2 ENSG00000121671 Cryptochrome-2 [Source:UniProtKB/Swiss-Prot;Acc:Q49AN0] 6.94 6.49 -0.45 -1.37 9.19E-06 1.47E-04 1.06E-06 9.73E-06 0.45 4 hsa-miR-206,hsa-miR-222,hsa-miR-24,hsa-miR-7,

TSPAN2 ENSG00000134198 Tetraspanin-2 (Tspan-2) [Source:UniProtKB/Swiss-Prot;Acc:O60636] 8.06 7.61 -0.45 -1.37 1.03E-04 1.05E-03 2.72E-06 2.28E-05 0.50 1 hsa-miR-7,

ZNF792 ENSG00000180884 Zinc finger protein 792 [Source:UniProtKB/Swiss-Prot;Acc:Q3KQV3] 6.58 6.14 -0.44 -1.36 7.45E-04 5.38E-03 1.44E-03 6.32E-03 0.44 2 hsa-miR-155,hsa-miR-7, RGM domain family member B Precursor [Source:UniProtKB/Swiss- RGMB ENSG00000174136 Prot;Acc:Q6NW40] 6.27 5.84 -0.43 -1.35 3.64E-04 2.98E-03 9.10E-04 4.23E-03 0.43 3 hsa-miR-18a,hsa-miR-19a,hsa-miR-7, Amphoterin-induced protein 1 Precursor (AMIGO-1)(Alivin-2) AMIGO1 ENSG00000181754 [Source:UniProtKB/Swiss-Prot;Acc:Q86WK6] 6.78 6.36 -0.43 -1.35 2.61E-04 2.26E-03 4.75E-04 2.37E-03 0.43 1 hsa-miR-155, Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I kappa-B kinase epsilon)(IkBKE)(IKK-epsilon)(IKK-E)(EC 2.7.11.10)(Inducible I IKBKE ENSG00000143466 kappa-B kinase)(IKK-i) [Source:UniProtKB/Swiss-Prot;Acc:Q14164] 7.18 6.75 -0.43 -1.35 2.37E-04 2.09E-03 9.61E-06 7.13E-05 0.43 3 hsa-miR-155,hsa-miR-24,hsa-miR-7, Huntingtin-interacting protein 1-related protein (Hip1-related)(Hip 12) HIP1R ENSG00000130787 [Source:UniProtKB/Swiss-Prot;Acc:O75146] 7.03 6.61 -0.42 -1.34 1.68E-05 2.41E-04 1.11E-07 1.30E-06 0.46 2 hsa-miR-132,hsa-miR-24, IgG receptor FcRn large subunit p51 Precursor (FcRn)(Neonatal Fc receptor)(IgG Fc fragment receptor transporter alpha chain) FCGRT ENSG00000104870 [Source:UniProtKB/Swiss-Prot;Acc:P55899] 7.41 6.99 -0.42 -1.34 2.14E-06 4.55E-05 2.85E-08 3.84E-07 0.43 1 hsa-miR-24, Lethal(2) giant larvae protein homolog 2 (HGL) LLGL2 ENSG00000073350 [Source:UniProtKB/Swiss-Prot;Acc:Q6P1M3] 7.01 6.59 -0.42 -1.34 3.54E-07 1.04E-05 5.12E-09 8.21E-08 0.42 1 hsa-miR-19a, E3 ubiquitin-protein ligase parkin (EC 6.3.2.-)(Parkinson juvenile disease protein 2)(Parkinson disease protein 2) PARK2 ENSG00000185345 [Source:UniProtKB/Swiss-Prot;Acc:O60260] 6.30 5.88 -0.42 -1.34 9.10E-04 6.32E-03 4.86E-03 1.79E-02 0.42 2 hsa-miR-155,hsa-miR-7, Ankyrin repeat domain-containing protein 13D ANKRD13D ENSG00000172932 [Source:UniProtKB/Swiss-Prot;Acc:Q6ZTN6] 7.00 6.58 -0.42 -1.34 1.38E-03 8.81E-03 1.24E-04 7.11E-04 0.42 1 hsa-miR-424, Neural cell adhesion molecule 1 Precursor (NCAM-1)(N-CAM- NCAM1 ENSG00000149294 1)(CD56 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P13591] 6.31 5.90 -0.41 -1.33 1.18E-03 7.78E-03 1.49E-03 6.54E-03 0.47 3 hsa-miR-200b,hsa-miR-210,hsa-miR-27a, PLXND1 ENSG00000004399 Plexin-D1 Precursor [Source:UniProtKB/Swiss-Prot;Acc:Q9Y4D7] 7.10 6.69 -0.41 -1.33 8.16E-05 8.72E-04 2.14E-06 1.84E-05 0.41 1 hsa-miR-27a, Zinc finger protein 385A (Hematopoietic zinc finger protein)(Retinal ZNF385A ENSG00000161642 zinc finger protein) [Source:UniProtKB/Swiss-Prot;Acc:Q96PM9] 7.18 6.77 -0.41 -1.33 1.25E-03 8.17E-03 3.61E-03 1.40E-02 0.41 4 hsa-miR-218,hsa-miR-221,hsa-miR-27a,hsa-miR-7, Multiple epidermal growth factor-like domains 6 Precursor (EGF-like domain-containing protein 3)(Multiple EGF-like domain protein 3) MEGF6 ENSG00000162591 [Source:UniProtKB/Swiss-Prot;Acc:O75095] 7.29 6.89 -0.40 -1.32 1.48E-05 2.18E-04 2.41E-06 2.05E-05 0.40 1 hsa-miR-155, UPF0452 protein C7orf41 (Protein Ells1) [Source:UniProtKB/Swiss- C7orf41 ENSG00000180354 Prot;Acc:Q8N3F0] 6.74 6.34 -0.40 -1.32 3.29E-04 2.75E-03 5.48E-04 2.69E-03 0.40 5 hsa-miR-155,hsa-miR-218,hsa-miR-27a,hsa-miR-7,hsa-miR-93, Protein patched homolog 1 (PTC1)(PTC) [Source:UniProtKB/Swiss- PTCH1 ENSG00000185920 Prot;Acc:Q13635] 6.47 6.07 -0.40 -1.32 4.41E-04 3.48E-03 2.79E-06 2.33E-05 0.47 2 hsa-miR-24,hsa-miR-27a, SPARC Precursor (Secreted protein acidic and rich in cysteine)(Osteonectin)(ON)(Basement-membrane protein 40)(BM- SPARC ENSG00000113140 40) [Source:UniProtKB/Swiss-Prot;Acc:P09486] 6.39 6.00 -0.39 -1.31 1.77E-05 2.51E-04 1.85E-05 1.28E-04 0.39 2 hsa-miR-155,hsa-miR-18a, Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B)(MVB12B)(Protein FAM125B) [Source:UniProtKB/Swiss- FAM125B ENSG00000196814 Prot;Acc:Q9H7P6] 6.96 6.57 -0.39 -1.31 1.65E-06 3.70E-05 1.85E-07 2.06E-06 0.50 3 hsa-miR-155,hsa-miR-218,hsa-miR-27a, Oxysterol-binding protein-related protein 7 (OSBP-related protein OSBPL7 ENSG00000006025 7)(ORP-7) [Source:UniProtKB/Swiss-Prot;Acc:Q9BZF2] 6.96 6.57 -0.39 -1.31 1.49E-05 2.19E-04 3.02E-07 3.17E-06 0.39 1 hsa-miR-221, Cardiotrophin-like cytokine factor 1 Precursor (B cell-stimulating factor 3)(BSF-3)(Novel neurotrophin-1)(NNT-1) CLCF1 ENSG00000175505 [Source:UniProtKB/Swiss-Prot;Acc:Q9UBD9] 6.77 6.39 -0.38 -1.31 4.33E-04 3.44E-03 1.41E-04 7.97E-04 0.42 1 hsa-miR-24, Macrophage colony-stimulating factor 1 receptor Precursor (CSF-1- R)(EC 2.7.10.1)(Fms proto-oncogene)(c-fms)(CD115 antigen) CSF1R ENSG00000182578 [Source:UniProtKB/Swiss-Prot;Acc:P07333] 6.66 6.27 -0.38 -1.30 4.91E-04 3.80E-03 1.01E-04 5.92E-04 0.38 1 hsa-miR-155, EH domain-containing protein 1 (Testilin)(hPAST1) EHD1 ENSG00000110047 [Source:UniProtKB/Swiss-Prot;Acc:Q9H4M9] 6.91 6.52 -0.38 -1.30 2.09E-04 1.89E-03 7.35E-05 4.45E-04 0.38 3 hsa-miR-155,hsa-miR-21,hsa-miR-7, Epididymis-specific alpha-mannosidase Precursor (EC 3.2.1.24)(Mannosidase alpha class 2B member 2) MAN2B2 ENSG00000013288 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2E5] 6.85 6.47 -0.38 -1.30 1.19E-03 7.85E-03 1.14E-04 6.60E-04 0.42 1 hsa-miR-155, Uncharacterized protein C7orf43 [Source:UniProtKB/Swiss- C7orf43 ENSG00000146826 Prot;Acc:Q8WVR3] 7.00 6.62 -0.38 -1.30 1.55E-03 9.64E-03 1.25E-04 7.17E-04 0.38 2 hsa-miR-200b,hsa-miR-206, Protocadherin-16 Precursor (Protein dachsous homolog 1)(Cadherin- 19)(Cadherin-25)(Fibroblast cadherin-1) [Source:UniProtKB/Swiss- DCHS1 ENSG00000166341 Prot;Acc:Q96JQ0] 6.75 6.38 -0.37 -1.29 8.53E-05 9.03E-04 5.44E-07 5.37E-06 0.42 1 hsa-miR-24, Electrogenic sodium bicarbonate cotransporter 4 (Solute carrier family 4 member 5)(NBCe2) [Source:UniProtKB/Swiss- SLC4A5 ENSG00000188687 Prot;Acc:Q9BY07] 7.08 6.72 -0.37 -1.29 4.98E-05 5.82E-04 5.55E-06 4.34E-05 0.37 1 hsa-miR-130b, Leucine-rich repeat-containing protein 8A [Source:UniProtKB/Swiss- LRRC8A ENSG00000136802 Prot;Acc:Q8IWT6] 7.20 6.83 -0.37 -1.29 5.08E-06 9.18E-05 7.37E-06 5.61E-05 0.37 4 hsa-miR-18a,hsa-miR-200b,hsa-miR-210,hsa-miR-7, Oxysterol-binding protein-related protein 5 (OSBP-related protein 5)(ORP-5)(Oxysterol-binding protein homolog 1;) OSBPL5 ENSG00000021762 [Source:UniProtKB/Swiss-Prot;Acc:Q9H0X9] 6.67 6.31 -0.36 -1.29 3.53E-06 6.87E-05 5.03E-07 5.01E-06 0.42 1 hsa-miR-7, VASH1 ENSG00000071246 Vasohibin-1 [Source:UniProtKB/Swiss-Prot;Acc:Q7L8A9] 7.08 6.73 -0.36 -1.28 2.67E-04 2.30E-03 5.01E-04 2.48E-03 0.36 2 hsa-miR-200b,hsa-miR-222, Translocating chain-associated membrane protein 2 TRAM2 ENSG00000065308 [Source:UniProtKB/Swiss-Prot;Acc:Q15035] 6.90 6.55 -0.35 -1.28 1.55E-04 1.48E-03 2.40E-05 1.62E-04 0.39 4 hsa-miR-18a,hsa-miR-221,hsa-miR-24,hsa-miR-7, Neuron navigator 1 (Steerin-1)(Pore membrane and/or filament- interacting-like protein 3)(Unc-53 homolog 1)(unc53H1) NAV1 ENSG00000134369 [Source:UniProtKB/Swiss-Prot;Acc:Q8NEY1] 6.90 6.55 -0.35 -1.27 1.25E-04 1.24E-03 5.40E-05 3.38E-04 0.35 6 hsa-miR-18a,hsa-miR-19a,hsa-miR-221,hsa-miR-27a,hsa-miR-29b,hsa-miR-7, Mast/stem cell growth factor receptor Precursor (SCFR)(EC 2.7.10.1)(Proto-oncogene tyrosine-protein kinase Kit)(c-kit)(CD117 KIT ENSG00000157404 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P10721] 3.82 3.47 -0.35 -1.27 1.76E-05 2.51E-04 1.06E-07 1.25E-06 0.38 4 hsa-miR-18a,hsa-miR-19a,hsa-miR-218,hsa-miR-222, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11)(Phosphoinositide phospholipase C)(Phospholipase C- delta-1)(PLC-delta-1)(PLC-III) [Source:UniProtKB/Swiss- PLCD1 ENSG00000187091 Prot;Acc:P51178] 6.91 6.57 -0.34 -1.27 1.06E-05 1.65E-04 3.31E-08 4.39E-07 0.39 1 hsa-miR-424, Collagen alpha-2(VI) chain Precursor [Source:UniProtKB/Swiss- COL6A2 ENSG00000142173 Prot;Acc:P12110] 7.21 6.87 -0.34 -1.26 1.30E-05 1.96E-04 3.74E-07 3.83E-06 0.46 1 hsa-miR-7,

Voltage-dependent calcium channel subunit alpha-2/delta-2 Precursor (Voltage-gated calcium channel subunit alpha-2/delta-2) [Contains Voltage-dependent calcium channel subunit alpha-2-2;Voltage- CACNA2D2 ENSG00000007402 dependent calcium channel subunit delta-2] [Source:UniProtKB/ 7.19 6.86 -0.34 -1.26 1.80E-05 2.55E-04 3.90E-06 3.16E-05 0.34 2 hsa-miR-155,hsa-miR-210, Growth arrest-specific protein 7 (GAS-7) [Source:UniProtKB/Swiss- GAS7 ENSG00000007237 Prot;Acc:O60861] 6.64 6.31 -0.33 -1.26 3.63E-05 4.48E-04 7.85E-05 4.71E-04 0.33 3 hsa-miR-19a,hsa-miR-24,hsa-miR-7, MAP7 domain-containing protein 1 (Proline/arginine-rich coiled-coil domain-containing protein 1)(Arginine/proline-rich coiled-coil domain- MAP7D1 ENSG00000116871 containing protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q3KQU3] 7.66 7.34 -0.33 -1.25 2.71E-04 2.34E-03 4.87E-05 3.08E-04 0.33 1 hsa-miR-18a, Transcription factor MafK (Erythroid transcription factor NF-E2 p18 MAFK ENSG00000198517 subunit) [Source:UniProtKB/Swiss-Prot;Acc:O60675] 7.42 7.09 -0.33 -1.25 4.64E-05 5.50E-04 4.36E-05 2.79E-04 0.33 1 hsa-miR-132, Semaphorin-4F Precursor (Semaphorin-W)(Sema W)(Semaphorin- SEMA4F ENSG00000135622 M)(Sema M) [Source:UniProtKB/Swiss-Prot;Acc:O95754] 6.63 6.31 -0.32 -1.25 5.11E-05 5.95E-04 4.18E-04 2.12E-03 0.32 1 hsa-miR-27a, Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) ARHGEF11 ENSG00000132694 [Source:UniProtKB/Swiss-Prot;Acc:O15085] 6.70 6.38 -0.32 -1.25 3.42E-05 4.28E-04 3.42E-07 3.53E-06 0.37 1 hsa-miR-132, Aminomethyltransferase, mitochondrial Precursor (EC 2.1.2.10)(Glycine cleavage system T protein)(GCVT) AMT ENSG00000145020 [Source:UniProtKB/Swiss-Prot;Acc:P48728] 6.74 6.42 -0.32 -1.25 1.21E-03 7.92E-03 1.38E-05 9.89E-05 0.45 2 hsa-miR-155,hsa-miR-7, Uncharacterized protein KIAA1530 [Source:UniProtKB/Swiss- KIAA1530 ENSG00000163945 Prot;Acc:Q2YD98] 7.62 7.32 -0.31 -1.24 9.00E-04 6.27E-03 3.97E-04 2.02E-03 0.31 1 hsa-miR-7,

1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC 2.3.1.51)(1- acylglycerol-3-phosphate O-acyltransferase 4)(1-AGP acyltransferase 4)(1-AGPAT 4)(Lysophosphatidic acid acyltransferase delta)(LPAAT- AGPAT4 ENSG00000026652 delta) [Source:UniProtKB/Swiss-Prot;Acc:Q9NRZ5] 6.65 6.37 -0.28 -1.22 3.64E-04 2.98E-03 6.03E-06 4.68E-05 0.47 2 hsa-miR-221,hsa-miR-7, ROGDI ENSG00000067836 Protein rogdi homolog [Source:UniProtKB/Swiss-Prot;Acc:Q9GZN7] 8.60 8.33 -0.26 -1.20 6.80E-04 4.99E-03 1.75E-03 7.50E-03 0.26 1 hsa-miR-19a, Complement C1r subcomponent Precursor (EC 3.4.21.41)(Complement component 1, r subcomponent) [Contains Complement C1r subcomponent heavy chain;Complement C1r subcomponent light chain] [Source:UniProtKB/Swiss- C1R ENSG00000159403 Prot;Acc:P00736] 6.91 6.67 -0.24 -1.18 8.48E-04 5.97E-03 1.50E-03 6.55E-03 0.25 1 hsa-miR-7, Ras-specific guanine nucleotide-releasing factor RalGPS1 (RalA exchange factor RalGPS1)(Ral GEF with PH domain and SH3- RALGPS1 ENSG00000136828 binding motif 1) [Source:UniProtKB/Swiss-Prot;Acc:Q5JS13] 7.31 7.07 -0.24 -1.18 2.77E-04 2.38E-03 2.52E-04 1.34E-03 0.24 5 hsa-miR-19a,hsa-miR-218,hsa-miR-27a,hsa-miR-424,hsa-miR-7, Coiled-coil alpha-helical rod protein 1 (Alpha-helical coiled-coil rod protein)(Putative gene 8 protein)(Pg8) [Source:UniProtKB/Swiss- CCHCR1 ENSG00000204536 Prot;Acc:Q8TD31] 6.46 6.68 0.23 1.17 1.15E-03 7.62E-03 5.76E-04 2.81E-03 0.23 1 hsa-miR-424, UPF0635 protein C6orf134 [Source:UniProtKB/Swiss- C6orf134 ENSG00000137343 Prot;Acc:Q5SQI0] 6.14 6.38 0.25 1.19 1.22E-03 7.96E-03 1.08E-04 6.27E-04 0.35 2 hsa-miR-218,hsa-miR-7, Microtubule-associated serine/threonine-protein kinase 2 (EC MAST2 ENSG00000086015 2.7.11.1) [Source:UniProtKB/Swiss-Prot;Acc:Q6P0Q8] 6.66 6.91 0.25 1.19 1.93E-05 2.70E-04 6.26E-10 1.30E-08 0.38 1 hsa-miR-130b, Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.- )(Mahogunin RING finger protein 1)(RING finger protein 156) MGRN1 ENSG00000102858 [Source:UniProtKB/Swiss-Prot;Acc:O60291] 7.07 7.35 0.28 1.21 6.83E-04 5.00E-03 2.27E-04 1.23E-03 0.30 1 hsa-miR-210, Ankyrin repeat domain-containing protein 54 ANKRD54 ENSG00000100124 [Source:UniProtKB/Swiss-Prot;Acc:Q6NXT1] 6.40 6.70 0.29 1.23 5.72E-04 4.34E-03 7.24E-07 6.91E-06 0.57 1 hsa-miR-7, Dedicator of cytokinesis protein 3 (Modifier of cell adhesion)(Presenilin-binding protein)(PBP) DOCK3 ENSG00000088538 [Source:UniProtKB/Swiss-Prot;Acc:Q8IZD9] 6.43 6.73 0.30 1.23 2.35E-04 2.08E-03 1.04E-05 7.66E-05 0.37 3 hsa-miR-19b,hsa-miR-24,hsa-miR-7, Zinc finger MYND domain-containing protein 17 ZMYND17 ENSG00000166343 [Source:UniProtKB/Swiss-Prot;Acc:Q4VC12] 6.18 6.48 0.30 1.23 7.33E-04 5.31E-03 2.10E-02 5.90E-02 0.32 1 hsa-miR-18a, Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Precursor (EC 1.14.11.4)(Lysyl hydroxylase 1)(LH1) [Source:UniProtKB/Swiss- PLOD1 ENSG00000083444 Prot;Acc:Q02809] 6.21 6.52 0.31 1.24 3.77E-04 3.06E-03 8.89E-10 1.75E-08 0.67 1 hsa-miR-7, LIM domain kinase 2 (LIMK-2)(EC 2.7.11.1) [Source:UniProtKB/Swiss- LIMK2 ENSG00000182541 Prot;Acc:P53671] 6.61 6.93 0.32 1.25 4.39E-04 3.47E-03 3.18E-07 3.32E-06 0.50 3 hsa-miR-24,hsa-miR-27a,hsa-miR-98, F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein FBXL19 ENSG00000099364 19) [Source:UniProtKB/Swiss-Prot;Acc:Q6PCT2] 7.01 7.35 0.34 1.26 1.19E-05 1.83E-04 7.03E-08 8.70E-07 0.47 3 hsa-let-7f,hsa-miR-24,hsa-miR-7, Acetoacetyl-CoA synthetase (EC 6.2.1.16)(Acyl-CoA synthetase family member 1)(Protein sur-5 homolog) [Source:UniProtKB/Swiss- AACS ENSG00000081760 Prot;Acc:Q86V21] 6.17 6.51 0.34 1.27 1.61E-04 1.53E-03 2.06E-05 1.42E-04 0.48 2 hsa-miR-19a,hsa-miR-7, DNA repair protein RAD51 homolog 4 (R51H3)(RAD51-like protein RAD51L3 ENSG00000185379 3)(TRAD) [Source:UniProtKB/Swiss-Prot;Acc:O75771] 6.47 6.81 0.34 1.27 4.20E-05 5.05E-04 1.26E-08 1.85E-07 0.62 1 hsa-miR-424, Kinesin-like protein KIF1B (Klp) [Source:UniProtKB/Swiss- KIF1B ENSG00000054523 Prot;Acc:O60333] 6.28 6.63 0.35 1.27 2.73E-04 2.35E-03 7.17E-07 6.85E-06 0.48 2 hsa-miR-19a,hsa-miR-221, Fatty acid desaturase 3 (EC 1.14.19.-)(Cytochrome b5-related protein) FADS3 ENSG00000221968 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5Q0] 6.35 6.70 0.35 1.27 9.49E-04 6.53E-03 8.61E-04 4.03E-03 0.38 1 hsa-miR-7, Segment polarity protein dishevelled homolog DVL-3 (Dishevelled- DVL3 ENSG00000161202 3)(DSH homolog 3) [Source:UniProtKB/Swiss-Prot;Acc:Q92997] 6.94 7.29 0.35 1.28 9.23E-04 6.40E-03 7.01E-05 4.26E-04 0.39 3 hsa-let-7f,hsa-miR-18a,hsa-miR-24, Forkhead box protein P4 (Fork head-related protein-like A) FOXP4 ENSG00000137166 [Source:UniProtKB/Swiss-Prot;Acc:Q8IVH2] 6.28 6.63 0.35 1.28 1.14E-03 7.57E-03 6.62E-05 4.05E-04 0.43 3 hsa-miR-27a,hsa-miR-424,hsa-miR-7, Mesoderm induction early response protein 2 (Mi-er2) MIER2 ENSG00000105556 [Source:UniProtKB/Swiss-Prot;Acc:Q8N344] 6.19 6.55 0.35 1.28 9.32E-04 6.44E-03 1.12E-04 6.51E-04 0.45 2 hsa-miR-27a,hsa-miR-7, 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial Precursor (AKB ligase)(EC 2.3.1.29)(Glycine acetyltransferase)(Aminoacetone GCAT ENSG00000100116 synthetase) [Source:UniProtKB/Swiss-Prot;Acc:O75600] 6.17 6.53 0.35 1.28 1.09E-03 7.28E-03 3.90E-04 1.99E-03 0.47 1 hsa-miR-24, Glucose-6-phosphatase 3 (G-6-Pase 3)(G6Pase 3)(EC 3.1.3.9)(Glucose-6-phosphatase beta)(G6Pase-beta)(Ubiquitous glucose-6-phosphatase catalytic subunit-related protein) G6PC3 ENSG00000141349 [Source:UniProtKB/Swiss-Prot;Acc:Q9BUM1] 6.65 7.00 0.36 1.28 2.34E-04 2.07E-03 2.06E-11 6.44E-10 0.99 1 hsa-miR-27a, Protein Wnt-10a Precursor [Source:UniProtKB/Swiss- WNT10A ENSG00000135925 Prot;Acc:Q9GZT5] 6.84 7.20 0.36 1.28 1.34E-03 8.62E-03 4.38E-03 1.64E-02 0.36 1 hsa-miR-19a, Kunitz-type protease inhibitor 1 Precursor (Hepatocyte growth factor activator inhibitor type 1)(HAI-1) [Source:UniProtKB/Swiss- SPINT1 ENSG00000166145 Prot;Acc:O43278] 6.22 6.58 0.36 1.28 4.15E-04 3.32E-03 3.62E-06 2.95E-05 0.57 1 hsa-miR-7, SH3 domain-binding protein 2 (3BP-2) [Source:UniProtKB/Swiss- SH3BP2 ENSG00000087266 Prot;Acc:P78314] 6.89 7.25 0.37 1.29 2.78E-04 2.38E-03 2.95E-06 2.46E-05 0.44 3 hsa-miR-18a,hsa-miR-24,hsa-miR-7, Transcription factor AP-4 (Activating enhancer-binding protein 4) TFAP4 ENSG00000090447 [Source:UniProtKB/Swiss-Prot;Acc:Q01664] 6.31 6.68 0.38 1.30 5.82E-04 4.39E-03 4.25E-06 3.42E-05 0.57 1 hsa-miR-7, Calmodulin-binding transcription activator 2 CAMTA2 ENSG00000108509 [Source:UniProtKB/Swiss-Prot;Acc:O94983] 6.85 7.22 0.38 1.30 5.89E-04 4.43E-03 8.04E-07 7.59E-06 0.61 1 hsa-miR-93, Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1)(p21-activated PAK4 ENSG00000130669 kinase 4)(PAK-4) [Source:UniProtKB/Swiss-Prot;Acc:O96013] 6.70 7.08 0.38 1.30 4.65E-06 8.52E-05 5.54E-06 4.34E-05 0.38 1 hsa-miR-24, Syntaxin-binding protein 1 (Unc-18 homolog)(Unc-18-1)(Unc-18A)(N- STXBP1 ENSG00000136854 Sec1)(p67) [Source:UniProtKB/Swiss-Prot;Acc:P61764] 6.46 6.85 0.39 1.31 1.07E-07 3.97E-06 4.14E-10 9.03E-09 0.57 1 hsa-miR-218, 5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-)(Grp94- neighboring nucleotidase) [Source:UniProtKB/Swiss- NT5DC3 ENSG00000111696 Prot;Acc:Q86UY8] 6.48 6.88 0.39 1.31 8.20E-04 5.80E-03 2.48E-10 5.74E-09 0.91 1 hsa-miR-424, Uncharacterized protein C21orf58 [Source:UniProtKB/Swiss- C21orf58 ENSG00000160298 Prot;Acc:P58505] 6.26 6.65 0.39 1.31 3.27E-05 4.13E-04 6.88E-05 4.19E-04 0.43 1 hsa-miR-7, Growth factor receptor-bound protein 10 (GRB10 adapter protein)(Insulin receptor-binding protein Grb-IR) GRB10 ENSG00000106070 [Source:UniProtKB/Swiss-Prot;Acc:Q13322] 5.91 6.31 0.40 1.32 6.82E-05 7.56E-04 5.12E-07 5.08E-06 0.57 2 hsa-miR-19a,hsa-miR-222, BTB/POZ domain-containing protein KCTD5 KCTD5 ENSG00000167977 [Source:UniProtKB/Swiss-Prot;Acc:Q9NXV2] 6.98 7.38 0.40 1.32 1.01E-05 1.60E-04 1.15E-09 2.18E-08 0.47 1 hsa-miR-155, CALD1 ENSG00000122786 Caldesmon (CDM) [Source:UniProtKB/Swiss-Prot;Acc:Q05682] 6.37 6.77 0.40 1.32 9.53E-04 6.55E-03 2.90E-05 1.93E-04 0.40 2 hsa-miR-19a,hsa-miR-27a, BTB/POZ domain-containing protein KCTD10 KCTD10 ENSG00000110906 [Source:UniProtKB/Swiss-Prot;Acc:Q9H3F6] 6.48 6.89 0.40 1.32 7.31E-04 5.29E-03 5.20E-05 3.27E-04 0.49 1 hsa-miR-19a, Syntaxin-1A (Neuron-specific antigen HPC-1) STX1A ENSG00000106089 [Source:UniProtKB/Swiss-Prot;Acc:Q16623] 6.59 7.00 0.41 1.33 2.15E-06 4.57E-05 3.80E-10 8.40E-09 0.53 2 hsa-miR-27a,hsa-miR-424, PHF13 ENSG00000116273 PHD finger protein 13 [Source:UniProtKB/Swiss-Prot;Acc:Q86YI8] 6.92 7.32 0.41 1.33 5.38E-04 4.11E-03 5.72E-05 3.56E-04 0.41 3 hsa-miR-135b,hsa-miR-19a,hsa-miR-27a, Ribosomal protein S6 kinase alpha-1 (S6K-alpha 1)(EC 2.7.11.1)(90 kDa ribosomal protein S6 kinase 1)(p90-RSK 1)(pp90RSK1)(p90S6K)(Ribosomal S6 kinase 1)(RSK-1)(MAP kinase-activated protein kinase 1a)(MAPKAPK1A) RPS6KA1 ENSG00000117676 [Source:UniProtKB/Swiss-Prot;Acc:Q15418] 6.69 7.09 0.41 1.33 3.36E-04 2.79E-03 4.75E-05 3.02E-04 0.47 1 hsa-miR-93, UPF0692 protein C19orf54 [Source:UniProtKB/Swiss- C19orf54 ENSG00000188493 Prot;Acc:Q5BKX5] 6.79 7.21 0.41 1.33 4.26E-04 3.39E-03 3.49E-04 1.80E-03 0.41 1 hsa-miR-7, SEPT8 ENSG00000164402 Septin-8 [Source:UniProtKB/Swiss-Prot;Acc:Q92599] 6.05 6.46 0.41 1.33 1.51E-04 1.45E-03 2.63E-06 2.21E-05 0.60 3 hsa-miR-132,hsa-miR-27a,hsa-miR-7, B-cell lymphoma 3-encoded protein (Protein Bcl-3) BCL3 ENSG00000069399 [Source:UniProtKB/Swiss-Prot;Acc:P20749] 6.54 6.96 0.42 1.33 1.40E-03 8.88E-03 2.66E-05 1.78E-04 0.58 3 hsa-miR-19a,hsa-miR-27a,hsa-miR-7, Tight junction-associated protein 1 (Tight junction protein 4)(Protein incorporated later into tight junctions) [Source:UniProtKB/Swiss- TJAP1 ENSG00000137221 Prot;Acc:Q5JTD0] 6.44 6.86 0.42 1.34 2.52E-04 2.20E-03 9.69E-06 7.18E-05 0.50 2 hsa-miR-132,hsa-miR-7, DNA (cytosine-5)-methyltransferase 3A (Dnmt3a)(EC 2.1.1.37)(DNA methyltransferase HsaIIIA)(DNA MTase HsaIIIA)(M.HsaIIIA) DNMT3A ENSG00000119772 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y6K1] 6.71 7.13 0.42 1.34 6.46E-04 4.78E-03 1.18E-04 6.79E-04 0.42 3 hsa-miR-132,hsa-miR-200b,hsa-miR-218, Monoacylglycerol lipase ABHD6 (EC 3.1.1.23)(2- arachidonoylglycerol hydrolase)(Abhydrolase domain-containing ABHD6 ENSG00000163686 protein 6) [Source:UniProtKB/Swiss-Prot;Acc:Q9BV23] 5.91 6.34 0.42 1.34 6.44E-04 4.77E-03 6.90E-07 6.63E-06 0.92 2 hsa-miR-155,hsa-miR-27a, WWC3 ENSG00000047644 Protein WWC3 [Source:UniProtKB/Swiss-Prot;Acc:Q9ULE0] 6.28 6.70 0.42 1.34 9.75E-04 6.66E-03 3.07E-05 2.03E-04 0.51 1 hsa-miR-200b, Transcription factor E2F2 (E2F-2) [Source:UniProtKB/Swiss- E2F2 ENSG00000007968 Prot;Acc:Q14209] 6.36 6.79 0.43 1.35 4.69E-05 5.54E-04 3.41E-11 1.00E-09 0.76 3 hsa-miR-155,hsa-miR-222,hsa-miR-365, Transcription factor E2F2 (E2F-2) [Source:UniProtKB/Swiss- E2F2 ENSG00000007968 Prot;Acc:Q14209] 6.36 6.79 0.43 1.35 4.69E-05 5.54E-04 3.41E-11 1.00E-09 0.76 3 hsa-miR-155,hsa-miR-222,hsa-miR-365, Uncharacterized protein C22orf13 (Protein LLN4) C22orf13 ENSG00000138867 [Source:UniProtKB/Swiss-Prot;Acc:Q96NT3] 7.19 7.64 0.45 1.36 5.91E-04 4.44E-03 3.80E-09 6.29E-08 0.92 3 hsa-miR-19a,hsa-miR-24,hsa-miR-7, Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2)(EC 4.2.1.96)(4- alpha-hydroxy-tetrahydropterin dehydratase 2)(DcoH-like protein DCoHm)(Dimerization cofactor of hepatocyte nuclear factor 1 from PCBD2 ENSG00000132570 muscle)(HNF-1-alpha dimerization cofactor) [Source:UniProtKB 6.97 7.42 0.46 1.37 3.05E-04 2.58E-03 7.47E-06 5.68E-05 0.46 1 hsa-miR-7, Glycerol-3-phosphate transporter (G-3-P transporter)(G-3-P permease)(Solute carrier family 37 member 1) SLC37A1 ENSG00000160190 [Source:UniProtKB/Swiss-Prot;Acc:P57057] 6.21 6.67 0.47 1.38 6.68E-05 7.42E-04 1.68E-06 1.48E-05 0.56 1 hsa-miR-19a, DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1)(EC 2.7.7.6)(DNA-directed RNA polymerase I subunit A)(DNA-directed RNA polymerase I largest subunit)(RNA polymerase I 194 kDa subunit)(RPA194)(A190) POLR1A ENSG00000068654 [Source:UniProtKB/Swiss-Prot;Acc:O 5.84 6.32 0.47 1.39 5.68E-04 4.31E-03 9.30E-08 1.11E-06 0.84 1 hsa-miR-132, Scavenger receptor class B member 1 (SRB1)(SR-BI)(CD36 antigen- like 1)(CD36 and LIMPII analogous 1)(CLA-1)(Collagen type I receptor, thrombospondin receptor-like 1)(CD36 antigen) SCARB1 ENSG00000073060 [Source:UniProtKB/Swiss-Prot;Acc:Q8WTV0] 5.97 6.44 0.48 1.39 6.47E-05 7.23E-04 6.74E-11 1.83E-09 0.99 1 hsa-miR-24, SFXN3 ENSG00000107819 Sideroflexin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q9BWM7] 6.39 6.87 0.48 1.39 1.44E-03 9.09E-03 2.30E-03 9.47E-03 0.48 1 hsa-miR-18a, RING finger protein 135 [Source:UniProtKB/Swiss- RNF135 ENSG00000181481 Prot;Acc:Q8IUD6] 6.47 6.95 0.48 1.39 2.30E-05 3.11E-04 2.31E-06 1.97E-05 0.54 1 hsa-miR-155, Isocitrate dehydrogenase [NADP] cytoplasmic (IDH)(EC 1.1.1.42)(Cytosolic NADP-isocitrate dehydrogenase)(Oxalosuccinate decarboxylase)(NADP(+)-specific ICDH)(IDP) IDH1 ENSG00000138413 [Source:UniProtKB/Swiss-Prot;Acc:O75874] 5.69 6.17 0.48 1.39 1.22E-03 8.01E-03 2.54E-08 3.47E-07 1.01 1 hsa-miR-155, Interleukin-1 receptor-associated kinase 1 (IRAK-1)(EC 2.7.11.1) IRAK1 ENSG00000184216 [Source:UniProtKB/Swiss-Prot;Acc:P51617] 6.52 7.01 0.49 1.40 2.30E-05 3.11E-04 2.27E-09 3.99E-08 0.74 1 hsa-miR-222, Melanoma-associated antigen F1 (MAGE-F1 antigen) MAGEF1 ENSG00000177383 [Source:UniProtKB/Swiss-Prot;Acc:Q9HAY2] 7.18 7.67 0.49 1.40 6.50E-06 1.11E-04 2.67E-11 8.06E-10 0.96 1 hsa-miR-132, Exonuclease 3'-5' domain-containing protein 2 (Exonuclease 3'-5' domain-like-containing protein 2) [Source:UniProtKB/Swiss- EXDL2 ENSG00000081177 Prot;Acc:Q9NVH0] 6.47 6.96 0.49 1.40 1.33E-05 1.99E-04 1.17E-04 6.73E-04 0.49 1 hsa-miR-7, Tetraspanin-31 (Tspan-31)(Sarcoma-amplified sequence) TSPAN31 ENSG00000135452 [Source:UniProtKB/Swiss-Prot;Acc:Q12999] 6.75 7.24 0.49 1.40 4.26E-04 3.39E-03 8.36E-05 4.98E-04 0.49 1 hsa-miR-7, GPI mannosyltransferase 1 (EC 2.4.1.-)(GPI mannosyltransferase I)(GPI-MT-I)(Phosphatidylinositol-glycan biosynthesis class M PIGM ENSG00000143315 protein)(PIG-M) [Source:UniProtKB/Swiss-Prot;Acc:Q9H3S5] 6.13 6.62 0.49 1.40 7.53E-04 5.42E-03 2.01E-06 1.74E-05 0.80 3 hsa-miR-132,hsa-miR-27a,hsa-miR-7, Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48)(EC 3.1.3.16)(SSH-1L)(hSSH-1L) [Source:UniProtKB/Swiss- SSH1 ENSG00000084112 Prot;Acc:Q8WYL5] 6.52 7.01 0.49 1.41 4.05E-04 3.25E-03 2.86E-04 1.51E-03 0.49 1 hsa-miR-218, PHD finger protein 7 (Testis development protein NYD-SP6) PHF7 ENSG00000010318 [Source:UniProtKB/Swiss-Prot;Acc:Q9BWX1] 6.15 6.64 0.49 1.41 1.04E-03 7.02E-03 1.93E-05 1.34E-04 0.50 2 hsa-miR-18a,hsa-miR-7, LITAF-like protein (Transmembrane protein I1)(Cell death-inducing C16orf5 ENSG00000089486 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9H305] 6.40 6.90 0.49 1.41 5.37E-04 4.10E-03 7.77E-08 9.50E-07 0.80 1 hsa-miR-27a, ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase-interactor 1)(GRK-interacting protein 1)(Cool-associated and tyrosine-phosphorylated protein 1)(Cat-1) [Source:UniProtKB/Swiss- GIT1 ENSG00000108262 Prot;Acc:Q9Y2X7] 6.70 7.20 0.50 1.41 6.17E-04 4.60E-03 2.05E-07 2.25E-06 0.88 1 hsa-miR-24, Prostacyclin synthase (EC 5.3.99.4)(Prostaglandin I2 synthase) PTGIS ENSG00000124212 [Source:UniProtKB/Swiss-Prot;Acc:Q16647] 6.28 6.78 0.50 1.41 1.19E-05 1.82E-04 2.38E-10 5.55E-09 0.88 1 hsa-miR-155, Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G)(hMAF) [Source:UniProtKB/Swiss- MAFG ENSG00000197063 Prot;Acc:O15525] 6.29 6.79 0.50 1.41 2.10E-04 1.90E-03 1.14E-10 2.90E-09 0.92 4 hsa-miR-18a,hsa-miR-218,hsa-miR-24,hsa-miR-7, Tudor and KH domain-containing protein [Source:UniProtKB/Swiss- TDRKH ENSG00000182134 Prot;Acc:Q9Y2W6] 6.16 6.66 0.50 1.42 2.57E-04 2.23E-03 6.62E-05 4.05E-04 0.64 2 hsa-miR-18a,hsa-miR-221, Membrane progestin receptor alpha (mPR alpha)(Progestin and adipoQ receptor family member VII) [Source:UniProtKB/Swiss- PAQR7 ENSG00000182749 Prot;Acc:Q86WK9] 6.14 6.65 0.50 1.42 1.56E-03 9.69E-03 9.38E-05 5.53E-04 0.64 2 hsa-miR-363,hsa-miR-365, Solute carrier family 25 member 44 [Source:UniProtKB/Swiss- SLC25A44 ENSG00000160785 Prot;Acc:Q96H78] 6.15 6.65 0.50 1.42 4.51E-06 8.34E-05 1.88E-08 2.65E-07 0.84 5 hsa-miR-130b,hsa-miR-19a,hsa-miR-222,hsa-miR-27a,hsa-miR-7, Complement C1q tumor necrosis factor-related protein 3 Precursor (Secretory protein CORS26) [Source:UniProtKB/Swiss- C1QTNF3 ENSG00000082196 Prot;Acc:Q9BXJ4] 6.37 6.88 0.50 1.42 2.19E-06 4.66E-05 3.14E-09 5.36E-08 0.69 1 hsa-miR-18a, NAD-dependent deacetylase sirtuin-3, mitochondrial Precursor (EC 3.5.1.-)(SIR2-like protein 3)(hSIRT3) [Source:UniProtKB/Swiss- SIRT3 ENSG00000142082 Prot;Acc:Q9NTG7] 7.01 7.51 0.50 1.42 5.69E-06 1.00E-04 1.16E-05 8.45E-05 0.50 1 hsa-miR-365, RNA polymerase II-associated protein 1 [Source:UniProtKB/Swiss- RPAP1 ENSG00000103932 Prot;Acc:Q9BWH6] 6.32 6.83 0.51 1.42 2.79E-05 3.63E-04 1.09E-08 1.62E-07 0.74 1 hsa-miR-155, Ankyrin repeat domain-containing protein 13B ANKRD13B ENSG00000198720 [Source:UniProtKB/Swiss-Prot;Acc:Q86YJ7] 5.77 6.28 0.51 1.42 1.16E-05 1.78E-04 1.06E-11 3.58E-10 0.86 1 hsa-miR-218, Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-)(Retinal short- chain dehydrogenase/reductase 1)(retSDR1)(DD83.1) DHRS3 ENSG00000162496 [Source:UniProtKB/Swiss-Prot;Acc:O75911] 6.89 7.40 0.51 1.43 1.07E-03 7.17E-03 8.08E-05 4.83E-04 0.51 1 hsa-miR-19a, Serum response factor (SRF) [Source:UniProtKB/Swiss- SRF ENSG00000112658 Prot;Acc:P11831] 6.52 7.03 0.51 1.43 4.25E-05 5.09E-04 4.32E-06 3.47E-05 0.58 3 hsa-miR-24,hsa-miR-365,hsa-miR-7, Solute carrier family 41 member 1 [Source:UniProtKB/Swiss- SLC41A1 ENSG00000133065 Prot;Acc:Q8IVJ1] 6.46 6.98 0.52 1.43 9.26E-04 6.41E-03 1.55E-05 1.10E-04 0.86 2 hsa-miR-18a,hsa-miR-24, Galactokinase (EC 2.7.1.6)(Galactose kinase) GALK1 ENSG00000108479 [Source:UniProtKB/Swiss-Prot;Acc:P51570] 6.50 7.02 0.52 1.43 5.16E-06 9.28E-05 7.28E-09 1.13E-07 0.81 1 hsa-miR-7, Caspase-9 Precursor (CASP-9)(EC 3.4.22.62)(ICE-like apoptotic protease 6)(ICE-LAP6)(Apoptotic protease Mch-6)(Apoptotic protease-activating factor 3)(APAF-3) [Contains Caspase-9 subunit p35;Caspase-9 subunit p10] [Source:UniProtKB/Swiss- CASP9 ENSG00000132906 Prot;Acc:P55211] 6.27 6.79 0.53 1.44 4.71E-04 3.68E-03 4.83E-04 2.40E-03 0.53 2 hsa-miR-155,hsa-miR-7, Phosphatidylserine decarboxylase proenzyme (EC 4.1.1.65) [Contains Phosphatidylserine decarboxylase alpha chain;Phosphatidylserine decarboxylase beta chain] [Source:UniProtKB/Swiss- PISD ENSG00000183530 Prot;Acc:Q9UG56] 6.29 6.81 0.53 1.44 6.26E-04 4.65E-03 1.11E-05 8.14E-05 0.72 2 hsa-miR-200b,hsa-miR-27a,

Adenylate cyclase type 3 (EC 4.6.1.1)(Adenylate cyclase type III)(AC- III)(ATP pyrophosphate-lyase 3)(Adenylyl cyclase 3)(AC3)(Adenylate ADCY3 ENSG00000138031 cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266] 6.05 6.58 0.53 1.45 1.51E-05 2.21E-04 5.58E-13 2.69E-11 1.17 1 hsa-miR-27a, SPRY domain-containing SOCS box protein 1 (SSB-1) SPSB1 ENSG00000171621 [Source:UniProtKB/Swiss-Prot;Acc:Q96BD6] 6.44 6.97 0.53 1.45 1.53E-04 1.46E-03 1.20E-06 1.09E-05 0.65 3 hsa-miR-218,hsa-miR-24,hsa-miR-7, Fanconi anemia group E protein (Protein FACE) FANCE ENSG00000112039 [Source:UniProtKB/Swiss-Prot;Acc:Q9HB96] 5.96 6.50 0.54 1.45 4.96E-07 1.38E-05 2.78E-12 1.09E-10 0.80 1 hsa-miR-24, DNA ligase 3 (EC 6.5.1.1)(DNA ligase III)(Polydeoxyribonucleotide LIG3 ENSG00000005156 synthase [ATP] 3) [Source:UniProtKB/Swiss-Prot;Acc:P49916] 6.26 6.80 0.54 1.45 1.13E-03 7.50E-03 2.91E-08 3.91E-07 1.05 1 hsa-miR-7, Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134)(Inositol- triphosphate 5/6-kinase)(EC 2.7.1.159)(Inositol 1,3,4-trisphosphate 5/6- kinase)(Ins(1,3,4)P(3) 5/6-kinase) [Source:UniProtKB/Swiss- ITPK1 ENSG00000100605 Prot;Acc:Q13572] 6.74 7.28 0.54 1.45 4.50E-04 3.54E-03 2.36E-08 3.26E-07 0.79 1 hsa-miR-24, CTTNBP2 N-terminal-like protein [Source:UniProtKB/Swiss- CTTNBP2NL ENSG00000143079 Prot;Acc:Q9P2B4] 6.31 6.85 0.54 1.46 6.94E-05 7.65E-04 8.01E-06 6.04E-05 0.54 1 hsa-miR-206, Forkhead box protein K2 (Interleukin enhancer-binding factor 1)(Cellular transcription factor ILF-1)(FOXK1) FOXK2 ENSG00000141568 [Source:UniProtKB/Swiss-Prot;Acc:Q01167] 6.84 7.39 0.54 1.46 7.71E-05 8.35E-04 3.21E-07 3.34E-06 0.74 2 hsa-miR-106b,hsa-miR-7, Uncharacterized protein C17orf80 (Human lung cancer oncogene 8 protein)(HLC-8)(Cell migration-inducing gene 3 protein) C17orf80 ENSG00000141219 [Source:UniProtKB/Swiss-Prot;Acc:Q9BSJ5] 6.14 6.68 0.54 1.46 8.53E-05 9.03E-04 4.05E-07 4.11E-06 0.64 1 hsa-miR-155, Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) HSPA2 ENSG00000126803 [Source:UniProtKB/Swiss-Prot;Acc:P54652] 6.66 7.21 0.55 1.46 5.14E-06 9.25E-05 4.63E-07 4.65E-06 0.55 1 hsa-miR-19a, DCN1-like protein 3 (Defective in cullin neddylation protein 1-like protein 3)(DCUN1 domain-containing protein 3) DCUN1D3 ENSG00000188215 [Source:UniProtKB/Swiss-Prot;Acc:Q8IWE4] 6.31 6.85 0.55 1.46 1.43E-04 1.39E-03 1.36E-07 1.57E-06 0.90 4 hsa-miR-132,hsa-miR-155,hsa-miR-19a,hsa-miR-21, Protein phosphatase 1M (EC 3.1.3.16)(Protein phosphatase 2C isoform eta)(PP2C-eta)(PP2CE) [Source:UniProtKB/Swiss- PPM1M ENSG00000164088 Prot;Acc:Q96MI6] 6.84 7.39 0.55 1.47 1.16E-03 7.69E-03 1.64E-04 9.14E-04 0.57 1 hsa-miR-19a, ZNF642 ENSG00000187815 Zinc finger protein 642 [Source:UniProtKB/Swiss-Prot;Acc:Q49AA0] 6.17 6.73 0.55 1.47 7.23E-04 5.25E-03 3.30E-05 2.16E-04 0.55 1 hsa-miR-155, Abhydrolase domain-containing protein 4 (EC 3.1.1.-)(Lyso-N- acylphosphatidylethanolamine lipase)(Alpha/beta-hydrolase 4) ABHD4 ENSG00000100439 [Source:UniProtKB/Swiss-Prot;Acc:Q8TB40] 6.20 6.76 0.56 1.47 5.48E-06 9.71E-05 2.04E-07 2.25E-06 0.78 2 hsa-miR-21,hsa-miR-24, Glutamate decarboxylase 1 (EC 4.1.1.15)(Glutamate decarboxylase 67 kDa isoform)(67 kDa glutamic acid decarboxylase)(GAD-67) GAD1 ENSG00000128683 [Source:UniProtKB/Swiss-Prot;Acc:Q99259] 6.24 6.79 0.56 1.47 1.27E-03 8.27E-03 9.61E-04 4.44E-03 0.65 1 hsa-miR-24, Beta-1,4-galactosyltransferase 2 (Beta-1,4-GalTase 2)(Beta4Gal- T2)(b4Gal-T2)(EC 2.4.1.-)(UDP-galactose:beta-N- acetylglucosamine beta-1,4-galactosyltransferase 2)(UDP-Gal:beta- B4GALT2 ENSG00000117411 GlcNAc beta-1,4-galactosyltransferase 2) [Includes Lactose synthase 6.47 7.03 0.56 1.47 2.14E-06 4.56E-05 2.46E-11 7.48E-10 0.89 2 hsa-miR-19a,hsa-miR-7, Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47)(Transcription factor 3)(TCF-3)(Immunoglobulin transcription factor 1)(Transcription factor ITF-1)(Kappa-E2-binding TCF3 ENSG00000071564 factor) [Source:UniProtKB/Swiss-Prot;Acc:P15923] 6.60 7.16 0.56 1.47 1.26E-04 1.24E-03 6.02E-06 4.67E-05 0.66 2 hsa-miR-221,hsa-miR-24, GRAM domain-containing protein 4 (Death-inducing protein) TSC22D3 ENSG00000075240 [Source:UniProtKB/Swiss-Prot;Acc:Q6IC98] 6.34 6.89 0.56 1.47 3.02E-06 6.08E-05 7.73E-07 7.34E-06 0.60 2 hsa-miR-221,hsa-miR-24, Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit)(CPSF 30 kDa subunit)(NS1 effector domain-binding protein 1)(Neb-1)(No arches CPSF4 ENSG00000160917 homolog) [Source:UniProtKB/Swiss-Prot;Acc:O95639] 6.66 7.22 0.56 1.47 8.11E-06 1.33E-04 1.85E-09 3.34E-08 0.77 1 hsa-miR-24, Zinc finger protein 212 (Zinc finger protein C2H2-150) ZNF212 ENSG00000170260 [Source:UniProtKB/Swiss-Prot;Acc:Q9UDV6] 7.06 7.62 0.56 1.47 4.32E-10 4.47E-08 8.92E-12 3.07E-10 0.56 2 hsa-miR-218,hsa-miR-7, Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1- associated protein 1)(Sra-1)(p140sra-1) [Source:UniProtKB/Swiss- CYFIP1 ENSG00000068793 Prot;Acc:Q7L576] 5.75 6.31 0.56 1.47 3.16E-05 4.02E-04 2.30E-09 4.05E-08 0.92 1 hsa-miR-155, Zinc finger protein 37A (Zinc finger protein KOX21) ZNF37A ENSG00000075407 [Source:UniProtKB/Swiss-Prot;Acc:P17032] 5.87 6.43 0.56 1.48 1.57E-03 9.73E-03 7.20E-04 3.44E-03 0.62 1 hsa-miR-218, Chromatin assembly factor 1 subunit A (CAF-1 subunit A)(Chromatin assembly factor I p150 subunit)(CAF-I 150 kDa subunit)(CAF- CHAF1A ENSG00000167670 Ip150)(hp150) [Source:UniProtKB/Swiss-Prot;Acc:Q13111] 6.44 7.01 0.57 1.48 2.69E-07 8.44E-06 1.30E-11 4.28E-10 0.73 1 hsa-miR-155, Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial Precursor (Glu-ADT subunit B)(EC 6.3.5.- )(Cytochrome oxidase assembly factor PET112 homolog) PET112L ENSG00000059691 [Source:UniProtKB/Swiss-Prot;Acc:O75879] 5.90 6.46 0.57 1.48 1.08E-04 1.09E-03 4.23E-07 4.28E-06 0.82 1 hsa-miR-132, Aspartyl aminopeptidase (EC 3.4.11.21) [Source:UniProtKB/Swiss- DNPEP ENSG00000123992 Prot;Acc:Q9ULA0] 6.94 7.51 0.57 1.48 1.38E-03 8.82E-03 5.64E-10 1.18E-08 1.27 1 hsa-miR-7, Cysteine protease ATG4B (EC 3.4.22.-)(Autophagy-related protein 4 homolog B)(hAPG4B)(Autophagin-1)(Autophagy-related cysteine endopeptidase 1)(AUT-like 1 cysteine endopeptidase) ATG4B ENSG00000168397 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y4P1] 6.51 7.08 0.57 1.48 9.87E-04 6.72E-03 6.75E-05 4.12E-04 0.73 1 hsa-miR-424, JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-)(Jumonji domain-containing protein 2A) JMJD2A ENSG00000066135 [Source:UniProtKB/Swiss-Prot;Acc:O75164] 6.14 6.71 0.57 1.49 6.52E-05 7.27E-04 1.82E-05 1.26E-04 0.57 2 hsa-miR-200b,hsa-miR-7, cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17)(DPDE2)(PDE46) [Source:UniProtKB/Swiss- PDE4A ENSG00000065989 Prot;Acc:P27815] 6.26 6.84 0.57 1.49 1.22E-07 4.46E-06 3.56E-08 4.68E-07 0.57 2 hsa-miR-19a,hsa-miR-7, Forkhead box protein P3 (Scurfin) [Source:UniProtKB/Swiss- FOXP3 ENSG00000049768 Prot;Acc:Q9BZS1] 5.98 6.55 0.57 1.49 2.13E-06 4.54E-05 5.24E-07 5.19E-06 0.57 2 hsa-miR-210,hsa-miR-24, Dolichyldiphosphatase 1 (EC 3.6.1.43)(Dolichyl pyrophosphate DOLPP1 ENSG00000167130 phosphatase 1) [Source:UniProtKB/Swiss-Prot;Acc:Q86YN1] 6.12 6.70 0.58 1.50 2.07E-04 1.88E-03 2.90E-07 3.06E-06 0.83 1 hsa-miR-218, Nuclear migration protein nudC (Nuclear distribution protein C NUDC ENSG00000090273 homolog) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y266] 6.87 7.45 0.58 1.50 1.91E-04 1.76E-03 1.40E-10 3.47E-09 1.21 1 hsa-miR-132, POU domain, class 2, transcription factor 2 (Octamer-binding transcription factor 2)(Oct-2)(OTF-2)(Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) POU2F2 ENSG00000028277 [Source:UniProtKB/Swiss-Prot;Acc:P09086] 6.43 7.01 0.58 1.50 1.08E-05 1.69E-04 3.09E-06 2.56E-05 0.58 2 hsa-miR-210,hsa-miR-365, Double-stranded RNA-specific editase 1 (EC 3.5.-.-)(dsRNA adenosine deaminase)(RNA-editing deaminase 1)(RNA-editing ADARB1 ENSG00000197381 enzyme 1) [Source:UniProtKB/Swiss-Prot;Acc:P78563] 6.03 6.62 0.58 1.50 1.12E-03 7.45E-03 1.22E-04 7.01E-04 0.61 1 hsa-miR-218, NFATC2-interacting protein (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)(45 kDa NF-AT-interacting protein)(45 kDa NFAT-interacting protein) [Source:UniProtKB/Swiss- NFATC2IP ENSG00000176953 Prot;Acc:Q8NCF5] 6.71 7.29 0.58 1.50 1.23E-03 8.04E-03 5.53E-06 4.33E-05 0.83 1 hsa-miR-7, Zinc finger MIZ domain-containing protein 1 (Retinoic acid-induced protein 17)(PIAS-like protein Zimp10) [Source:UniProtKB/Swiss- ZMIZ1 ENSG00000108175 Prot;Acc:Q9ULJ6] 6.35 6.94 0.59 1.50 1.11E-03 7.38E-03 3.26E-03 1.28E-02 0.59 2 hsa-miR-218,hsa-miR-7, Ankyrin repeat and SOCS box protein 1 (ASB-1) ASB1 ENSG00000065802 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y576] 6.44 7.03 0.59 1.51 2.31E-04 2.05E-03 6.87E-05 4.19E-04 0.59 2 hsa-miR-18a,hsa-miR-7, KIAA0664 ENSG00000132361 Protein KIAA0664 [Source:UniProtKB/Swiss-Prot;Acc:O75153] 5.84 6.43 0.59 1.51 2.07E-05 2.86E-04 5.51E-13 2.66E-11 1.20 1 hsa-miR-210, MYO1E ENSG00000157483 Myosin-Ie (Myosin-Ic) [Source:UniProtKB/Swiss-Prot;Acc:Q12965] 6.01 6.60 0.60 1.51 1.00E-05 1.58E-04 4.50E-07 4.52E-06 0.62 1 hsa-miR-155, Solute carrier family 25 member 39 [Source:UniProtKB/Swiss- SLC25A39 ENSG00000013306 Prot;Acc:Q9BZJ4] 7.43 8.03 0.60 1.51 9.69E-04 6.63E-03 2.46E-12 9.87E-11 1.56 1 hsa-miR-7, BTB/POZ domain-containing protein KCTD11 KCTD11 ENSG00000213859 [Source:UniProtKB/Swiss-Prot;Acc:Q693B1] 5.80 6.40 0.60 1.51 6.06E-04 4.53E-03 2.80E-04 1.48E-03 0.60 1 hsa-miR-24, ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50)(TNF-alpha-stimulated ABC protein) [Source:UniProtKB/Swiss- ABCF1 ENSG00000204574 Prot;Acc:Q8NE71] 7.12 7.72 0.60 1.52 3.26E-04 2.72E-03 7.65E-10 1.55E-08 1.06 2 hsa-miR-18a,hsa-miR-424, Casein kinase I isoform epsilon (CKI-epsilon)(CKIe)(EC 2.7.11.1) CSNK1E ENSG00000213923 [Source:UniProtKB/Swiss-Prot;Acc:P49674] 6.57 7.17 0.60 1.52 4.79E-04 3.73E-03 3.00E-05 1.98E-04 0.72 3 hsa-miR-210,hsa-miR-218,hsa-miR-7, Notchless protein homolog 1 [Source:UniProtKB/Swiss- NLE1 ENSG00000073536 Prot;Acc:Q9NVX2] 6.24 6.85 0.60 1.52 2.54E-06 5.24E-05 3.48E-08 4.60E-07 0.78 1 hsa-miR-7, AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1)(AP-3 complex subunit delta)(Delta-adaptin) AP3D1 ENSG00000065000 [Source:UniProtKB/Swiss-Prot;Acc:O14617] 7.05 7.65 0.61 1.52 4.42E-04 3.49E-03 1.29E-06 1.16E-05 0.85 1 hsa-miR-7, Probable RNA-binding protein 19 (RNA-binding motif protein 19) RBM19 ENSG00000122965 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y4C8] 6.30 6.91 0.61 1.53 1.01E-03 6.86E-03 2.78E-06 2.33E-05 0.84 1 hsa-miR-24, GRAM domain-containing protein 1A [Source:UniProtKB/Swiss- GRAMD1A ENSG00000089351 Prot;Acc:Q96CP6] 6.94 7.55 0.61 1.53 4.02E-04 3.23E-03 1.99E-04 1.08E-03 0.61 1 hsa-miR-93, Diphthamide biosynthesis protein 2 (DPH2 homolog)(HsDph2)(Diphthamide biosynthesis protein 2 homolog-like DPH2 ENSG00000132768 2)(DPH2-like 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQC3] 6.21 6.83 0.62 1.53 3.38E-04 2.80E-03 2.03E-11 6.35E-10 1.31 1 hsa-miR-7, TOLLIP ENSG00000078902 Toll-interacting protein [Source:UniProtKB/Swiss-Prot;Acc:Q9H0E2] 6.10 6.71 0.62 1.53 6.90E-05 7.62E-04 3.48E-07 3.59E-06 0.62 1 hsa-miR-221, Tumor necrosis factor receptor superfamily member 1B Precursor (Tumor necrosis factor receptor 2)(TNF-R2)(Tumor necrosis factor receptor type II)(p75)(p80 TNF-alpha receptor)(CD120b antigen)(Etanercept) [Contains Tumor necrosis factor receptor TNFRSF1B ENSG00000028137 superfamily 7.43 8.05 0.62 1.53 1.56E-03 9.69E-03 1.26E-04 7.23E-04 0.83 2 hsa-miR-19a,hsa-miR-24, TFE3 ENSG00000068323 Transcription factor E3 [Source:UniProtKB/Swiss-Prot;Acc:P19532] 6.20 6.82 0.62 1.54 4.10E-05 4.95E-04 1.37E-05 9.80E-05 0.62 1 hsa-miR-24, Fascin (Singed-like protein)(55 kDa actin-bundling protein)(p55) FSCN1 ENSG00000075618 [Source:UniProtKB/Swiss-Prot;Acc:Q16658] 6.57 7.19 0.62 1.54 5.90E-07 1.59E-05 2.05E-07 2.25E-06 0.62 4 hsa-miR-200b,hsa-miR-24,hsa-miR-29b,hsa-miR-7, Serine/threonine-protein phosphatase 2A regulatory subunit B' (PP2A, subunit B', PR53 isoform)(Phosphotyrosyl phosphatase PPP2R4 ENSG00000119383 activator)(PTPA) [Source:UniProtKB/Swiss-Prot;Acc:Q15257] 7.06 7.68 0.62 1.54 1.26E-03 8.21E-03 8.04E-07 7.59E-06 0.89 2 hsa-miR-19a,hsa-miR-218, DnaJ homolog subfamily A member 4 [Source:UniProtKB/Swiss- DNAJA4 ENSG00000140403 Prot;Acc:Q8WW22] 6.51 7.13 0.62 1.54 8.58E-04 6.03E-03 7.06E-07 6.75E-06 0.84 2 hsa-miR-218,hsa-miR-7, TBC1 domain family member 10B [Source:UniProtKB/Swiss- TBC1D10B ENSG00000169221 Prot;Acc:Q4KMP7] 6.46 7.08 0.62 1.54 7.14E-07 1.86E-05 3.97E-11 1.15E-09 0.79 1 hsa-miR-7, Zinc finger and BTB domain-containing protein 9 ZBTB9 ENSG00000213588 [Source:UniProtKB/Swiss-Prot;Acc:Q96C00] 5.43 6.05 0.63 1.54 4.42E-04 3.49E-03 2.07E-06 1.78E-05 0.98 1 hsa-miR-7, Leptin receptor Precursor (LEP-R)(OB receptor)(OB- R)(HuB219)(CD295 antigen) [Source:UniProtKB/Swiss- LEPR ENSG00000116678 Prot;Acc:P48357] 6.65 7.28 0.63 1.54 6.39E-04 4.74E-03 9.65E-05 5.67E-04 0.63 1 hsa-miR-200b, E3 ubiquitin-protein ligase RNF8 (EC 6.3.2.-)(RING finger protein 8) RNF8 ENSG00000112130 [Source:UniProtKB/Swiss-Prot;Acc:O76064] 6.23 6.86 0.63 1.55 8.06E-07 2.06E-05 3.81E-07 3.90E-06 0.66 2 hsa-miR-24,hsa-miR-7, Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor)(Type 1 InsP3 receptor)(IP3 receptor isoform ITPR1 ENSG00000150995 1)(InsP3R1)(IP3R) [Source:UniProtKB/Swiss-Prot;Acc:Q14643] 6.27 6.91 0.63 1.55 2.14E-04 1.93E-03 4.35E-04 2.20E-03 0.63 3 hsa-miR-19a,hsa-miR-200b,hsa-miR-365, Abl interactor 2 (Abelson interactor 2)(Abi-2)(Abl-binding protein 3)(AblBP3)(Arg-binding protein 1)(ArgBP1) ABI2 ENSG00000138443 [Source:UniProtKB/Swiss-Prot;Acc:Q9NYB9] 6.25 6.89 0.64 1.55 9.85E-04 6.71E-03 9.29E-05 5.47E-04 0.64 4 hsa-miR-155,hsa-miR-200b,hsa-miR-24,hsa-miR-7, Meckel syndrome type 1 protein [Source:UniProtKB/Swiss- MKS1 ENSG00000011143 Prot;Acc:Q9NXB0] 5.81 6.45 0.64 1.55 2.42E-05 3.24E-04 1.09E-08 1.63E-07 0.83 1 hsa-miR-7, T-lymphoma invasion and metastasis-inducing protein 2 (TIAM-2)(SIF and TIAM1-like exchange factor) [Source:UniProtKB/Swiss- TIAM2 ENSG00000146426 Prot;Acc:Q8IVF5] 5.77 6.40 0.64 1.56 5.57E-06 9.85E-05 7.89E-07 7.48E-06 0.64 1 hsa-miR-365, Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein) [Includes NAD-dependent methylenetetrahydrofolate dehydrogenase(EC MTHFD2L ENSG00000163738 1.5.1.15);Methenyltetrahydrofolate cy 6.16 6.80 0.64 1.56 5.97E-05 6.76E-04 6.45E-11 1.76E-09 0.92 1 hsa-miR-7, Cytosolic carboxypeptidase-like protein 5 (ATP/GTP-binding protein- AGBL5 ENSG00000084693 like 5) [Source:UniProtKB/Swiss-Prot;Acc:Q8NDL9] 6.13 6.77 0.64 1.56 3.05E-05 3.90E-04 3.07E-06 2.54E-05 0.64 1 hsa-miR-218, Major prion protein Precursor (PrP)(PrP27-30)(PrP33- 35C)(ASCR)(CD230 antigen) [Source:UniProtKB/Swiss- PRNP ENSG00000171867 Prot;Acc:P04156] 8.32 8.96 0.64 1.56 7.97E-04 5.67E-03 8.47E-06 6.36E-05 0.72 2 hsa-miR-155,hsa-miR-7, Trans-2-enoyl-CoA reductase, mitochondrial Precursor (HsNrbf- 1)(EC 1.3.1.38)(NRBF-1) [Source:UniProtKB/Swiss- MECR ENSG00000116353 Prot;Acc:Q9BV79] 6.13 6.77 0.64 1.56 3.99E-05 4.84E-04 7.44E-11 1.99E-09 1.17 1 hsa-miR-155, Adiponectin receptor protein 2 (Progestin and adipoQ receptor family ADIPOR2 ENSG00000006831 member II) [Source:UniProtKB/Swiss-Prot;Acc:Q86V24] 6.55 7.20 0.65 1.57 2.21E-04 1.98E-03 5.09E-05 3.21E-04 0.81 5 hsa-let-7f,hsa-miR-106b,hsa-miR-19a,hsa-miR-200b,hsa-miR-218, Ganglioside GM2 activator Precursor (GM2-AP)(Cerebroside sulfate activator protein)(Shingolipid activator protein 3)(SAP-3) [Contains Ganglioside GM2 activator isoform short] [Source:UniProtKB/Swiss- GM2A ENSG00000196743 Prot;Acc:P17900] 6.22 6.87 0.65 1.57 3.54E-04 2.92E-03 1.09E-03 4.95E-03 0.72 2 hsa-miR-200b,hsa-miR-7, Probable E3 ubiquitin-protein ligase HECTD2 (EC 6.3.2.-)(HECT domain-containing protein 2) [Source:UniProtKB/Swiss- HECTD2 ENSG00000165338 Prot;Acc:Q5U5R9] 6.83 7.48 0.65 1.57 7.71E-06 1.28E-04 2.11E-06 1.82E-05 0.81 4 hsa-miR-155,hsa-miR-218,hsa-miR-221,hsa-miR-7, UDP-glucose 4-epimerase (EC 5.1.3.2)(UDP-galactose 4- epimerase)(Galactowaldenase) [Source:UniProtKB/Swiss- GALE ENSG00000117308 Prot;Acc:Q14376] 6.12 6.77 0.66 1.57 2.09E-07 6.92E-06 1.19E-13 7.18E-12 1.16 1 hsa-miR-7, Ribonuclease H2 subunit C (RNase H2 subunit C)(Ribonuclease HI subunit C)(Aicardi-Goutieres syndrome 3 protein)(AGS3)(RNase H1 RNASEH2C ENSG00000172922 small subunit) [Source:UniProtKB/Swiss-Prot;Acc:Q8TDP1] 6.89 7.54 0.66 1.58 6.35E-04 4.71E-03 3.25E-06 2.68E-05 1.01 1 hsa-miR-24,

Adrenodoxin, mitochondrial Precursor (Adrenal ferredoxin)(Ferredoxin- FDX1 ENSG00000137714 1)(Hepatoredoxin) [Source:UniProtKB/Swiss-Prot;Acc:P10109] 6.79 7.45 0.66 1.58 1.47E-03 9.24E-03 8.29E-06 6.24E-05 1.05 1 hsa-miR-155, SNX11 ENSG00000002919 Sorting nexin-11 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5W9] 6.42 7.08 0.66 1.58 3.29E-04 2.75E-03 1.89E-06 1.64E-05 0.85 2 hsa-miR-29b,hsa-miR-7, Heparan sulfate 2-O-sulfotransferase 1 (2-O- sulfotransferase)(2OST)(EC 2.8.2.-) [Source:UniProtKB/Swiss- HS2ST1 ENSG00000153936 Prot;Acc:Q7LGA3] 6.58 7.24 0.66 1.58 3.46E-04 2.86E-03 1.96E-04 1.07E-03 0.66 6 hsa-miR-155,hsa-miR-19b,hsa-miR-200b,hsa-miR-424,hsa-miR-7,hsa-miR-98, Centrosomal protein of 41 kDa (Cep41)(Testis-specific gene A14 TSGA14 ENSG00000106477 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9BYV8] 6.18 6.84 0.66 1.58 2.66E-04 2.30E-03 6.58E-07 6.34E-06 0.83 3 hsa-miR-155,hsa-miR-200b,hsa-miR-7, BTB/POZ domain-containing protein TNFAIP1 (Tumor necrosis factor, alpha-induced protein 1, endothelial)(Protein B12) TNFAIP1 ENSG00000109079 [Source:UniProtKB/Swiss-Prot;Acc:Q13829] 5.82 6.48 0.66 1.58 1.39E-05 2.06E-04 1.58E-06 1.40E-05 0.84 3 hsa-miR-106b,hsa-miR-218,hsa-miR-7, SERAC1 ENSG00000122335 Protein SERAC1 [Source:UniProtKB/Swiss-Prot;Acc:Q96JX3] 5.83 6.49 0.66 1.58 2.83E-05 3.66E-04 4.11E-08 5.33E-07 0.94 2 hsa-miR-155,hsa-miR-7, Tetraspanin-13 (Tspan-13)(Transmembrane 4 superfamily member TSPAN13 ENSG00000106537 13)(Tetraspan NET-6) [Source:UniProtKB/Swiss-Prot;Acc:O95857] 6.00 6.66 0.66 1.58 3.73E-05 4.57E-04 2.31E-06 1.97E-05 1.19 2 hsa-miR-200b,hsa-miR-222, Component of gems 4 (Gemin-4)(p97) [Source:UniProtKB/Swiss- GEMIN4 ENSG00000179409 Prot;Acc:P57678] 5.90 6.57 0.67 1.59 5.52E-05 6.34E-04 9.50E-09 1.44E-07 1.05 1 hsa-miR-155, Tetratricopeptide repeat protein 4 (TPR repeat protein 4) C1orf175 ENSG00000184313 [Source:UniProtKB/Swiss-Prot;Acc:O95801] 6.30 6.97 0.67 1.59 2.65E-08 1.29E-06 2.34E-13 1.30E-11 0.97 1 hsa-miR-24, ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2)(Gamma-adaptin- related protein 2)(VHS domain and ear domain of gamma- GGA2 ENSG00000103365 adaptin)(Vear) [Source:UniProtKB/Swiss-Prot;Acc:Q9UJY4] 7.09 7.76 0.67 1.60 1.38E-03 8.81E-03 4.59E-05 2.92E-04 0.82 3 hsa-miR-222,hsa-miR-24,hsa-miR-7, Neuroplastin Precursor (Stromal cell-derived receptor 1)(SDR-1) NPTN ENSG00000156642 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y639] 7.08 7.75 0.67 1.60 6.22E-04 4.63E-03 1.63E-07 1.84E-06 0.94 2 hsa-miR-19a,hsa-miR-27a, Serine/threonine-protein kinase 40 (EC 2.7.11.1)(SINK-homologous serine/threonine-protein kinase)(Sugen kinase 495)(SgK495) STK40 ENSG00000196182 [Source:UniProtKB/Swiss-Prot;Acc:Q8N2I9] 6.75 7.43 0.68 1.60 1.41E-04 1.38E-03 7.88E-09 1.21E-07 1.11 3 hsa-miR-21,hsa-miR-27a,hsa-miR-7, Probable palmitoyltransferase ZDHHC5 (EC 2.3.1.-)(Zinc finger DHHC domain-containing protein 5)(DHHC-5)(Zinc finger protein ZDHHC5 ENSG00000156599 375) [Source:UniProtKB/Swiss-Prot;Acc:Q9C0B5] 6.67 7.36 0.68 1.60 4.78E-04 3.72E-03 1.25E-05 9.02E-05 0.82 1 hsa-miR-363, Homeobox protein Hox-B9 (Hox-2E)(Hox-2.5) HOXB9 ENSG00000170689 [Source:UniProtKB/Swiss-Prot;Acc:P17482] 5.76 6.44 0.68 1.60 5.05E-07 1.39E-05 2.75E-07 2.92E-06 0.92 1 hsa-miR-7, tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33)(tRNA(m7G46)-methyltransferase)(Methyltransferase-like METTL1 ENSG00000037897 protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q9UBP6] 5.62 6.30 0.68 1.61 2.22E-05 3.02E-04 1.10E-09 2.11E-08 1.24 1 hsa-miR-7, E3 ubiquitin-protein ligase NRDP1 (EC 6.3.2.-)(RING finger protein RNF41 ENSG00000181852 41) [Source:UniProtKB/Swiss-Prot;Acc:Q9H4P4] 6.52 7.20 0.69 1.61 3.53E-04 2.91E-03 7.06E-06 5.39E-05 0.81 4 hsa-miR-18a,hsa-miR-19a,hsa-miR-218,hsa-miR-7,

Myosin-10 (Myosin heavy chain 10)(Myosin heavy chain, non-muscle IIb)(Non-muscle myosin heavy chain IIb)(NMMHC II-b)(NMMHC- IIB)(Cellular myosin heavy chain, type B)(Non-muscle myosin heavy MYH10 ENSG00000133026 chain B)(NMMHC-B) [Source:UniProtKB/Swiss-Prot;Acc:P35580] 5.41 6.09 0.69 1.61 6.67E-05 7.42E-04 5.95E-05 3.69E-04 0.69 1 hsa-miR-27a, Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2)(Telomeric DNA-binding protein) [Source:UniProtKB/Swiss- TERF2 ENSG00000132604 Prot;Acc:Q15554] 7.36 8.05 0.69 1.61 8.28E-04 5.85E-03 1.62E-07 1.84E-06 1.06 1 hsa-miR-130b, Runt-related transcription factor 2 (Core-binding factor subunit alpha- 1)(CBF-alpha-1)(Acute myeloid leukemia 3 protein)(Oncogene AML- 3)(Polyomavirus enhancer-binding protein 2 alpha A subunit)(PEBP2- RUNX2 ENSG00000124813 alpha A)(PEA2-alpha A)(SL3-3 enhancer factor 1 alpha A 6.26 6.95 0.69 1.61 8.53E-05 9.03E-04 1.76E-09 3.20E-08 0.99 5 hsa-miR-155,hsa-miR-19a,hsa-miR-218,hsa-miR-221,hsa-miR-7, Transcription cofactor vestigial-like protein 4 (Vgl-4) VGLL4 ENSG00000144560 [Source:UniProtKB/Swiss-Prot;Acc:Q14135] 6.75 7.44 0.69 1.61 4.61E-06 8.49E-05 1.07E-06 9.88E-06 0.69 4 hsa-miR-130b,hsa-miR-19a,hsa-miR-222,hsa-miR-365, 5'-AMP-activated protein kinase subunit beta-1 (AMPK beta-1 PRKAB1 ENSG00000111725 chain)(AMPKb) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y478] 6.53 7.22 0.69 1.62 1.49E-04 1.44E-03 9.66E-05 5.67E-04 0.70 2 hsa-miR-130b,hsa-miR-200b, Growth factor receptor-bound protein 2 (Adapter protein GRB2)(SH2/SH3 adapter GRB2)(Protein Ash) GRB2 ENSG00000177885 [Source:UniProtKB/Swiss-Prot;Acc:P62993] 7.53 8.22 0.69 1.62 8.19E-04 5.79E-03 5.52E-05 3.45E-04 0.72 1 hsa-miR-27a, Segment polarity protein dishevelled homolog DVL-2 (Dishevelled- DVL2 ENSG00000004975 2)(DSH homolog 2) [Source:UniProtKB/Swiss-Prot;Acc:O14641] 6.49 7.18 0.69 1.62 3.96E-05 4.80E-04 1.46E-07 1.67E-06 0.91 1 hsa-miR-27a, Acyl-CoA dehydrogenase family member 9, mitochondrial Precursor ACAD9 ENSG00000177646 (ACAD-9)(EC 1.3.99.-) [Source:UniProtKB/Swiss-Prot;Acc:Q9H845] 5.88 6.57 0.69 1.62 9.02E-05 9.45E-04 7.65E-12 2.69E-10 1.38 1 hsa-miR-7, Probable Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3)(EC 3.4.11.9)(Aminopeptidase P3)(APP3) [Source:UniProtKB/Swiss- XPNPEP3 ENSG00000196236 Prot;Acc:Q9NQH7] 6.01 6.71 0.70 1.62 2.35E-05 3.16E-04 5.05E-07 5.02E-06 0.89 2 hsa-miR-155,hsa-miR-206, Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2)(Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2)(SPFH domain-containing protein 2) [Source:UniProtKB/Swiss- ERLIN2 ENSG00000147475 Prot;Acc:O94905] 5.68 6.37 0.70 1.62 4.05E-04 3.25E-03 1.40E-06 1.25E-05 0.87 1 hsa-miR-7, Mitofusin-2 (EC 3.6.5.-)(Transmembrane GTPase MFN2) MFN2 ENSG00000116688 [Source:UniProtKB/Swiss-Prot;Acc:O95140] 6.75 7.45 0.70 1.63 3.36E-04 2.79E-03 8.79E-08 1.06E-06 1.14 1 hsa-miR-221, Acetyl-CoA carboxylase 1 (EC 6.4.1.2)(ACC-alpha) [Includes Biotin carboxylase(EC 6.3.4.14)] [Source:UniProtKB/Swiss- ACACA ENSG00000132142 Prot;Acc:Q13085] 5.35 6.05 0.70 1.63 3.84E-06 7.31E-05 6.49E-13 3.07E-11 1.53 1 hsa-miR-24, Fatty acid synthase (EC 2.3.1.85) [Includes [Acyl-carrier-protein] S- acetyltransferase(EC 2.3.1.38);[Acyl-carrier-protein] S- malonyltransferase(EC 2.3.1.39);3-oxoacyl-[acyl-carrier-protein] FASN ENSG00000169710 synthase(EC 2.3.1.41);3-oxoacyl-[acyl-carrier-protein] reductase( 6.41 7.11 0.70 1.63 4.80E-04 3.73E-03 1.77E-13 1.03E-11 1.76 1 hsa-miR-27a, Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1)(NFAT transcription complex cytosolic component)(NF-ATc)(NFATc) NFATC1 ENSG00000131196 [Source:UniProtKB/Swiss-Prot;Acc:O95644] 6.75 7.45 0.70 1.63 1.31E-05 1.96E-04 9.50E-06 7.06E-05 0.70 2 hsa-miR-218,hsa-miR-7, Mitoferrin-1 (Mitochondrial iron transporter 1)(Solute carrier family 25 member 37)(Mitochondrial solute carrier protein) SLC25A37 ENSG00000147454 [Source:UniProtKB/Swiss-Prot;Acc:Q9NYZ2] 5.73 6.44 0.71 1.63 3.98E-04 3.21E-03 1.11E-08 1.65E-07 1.15 2 hsa-miR-221,hsa-miR-7, Beta-sarcoglycan (Beta-SG)(43 kDa dystrophin-associated glycoprotein)(43DAG)(A3b) [Source:UniProtKB/Swiss- SGCB ENSG00000163069 Prot;Acc:Q16585] 7.51 8.21 0.71 1.63 3.85E-06 7.32E-05 1.27E-10 3.19E-09 0.97 2 hsa-miR-155,hsa-miR-19a, Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) [Includes ATP-dependent dihydroxyacetone kinase(DHA kinase)(EC 2.7.1.29)(Glycerone kinase);FAD-AMP lyase (cyclizing)(EC 4.6.1.15)(FAD-AMP lyase (cyclic FMN DAK ENSG00000149476 forming))(FMN cyclase) 6.44 7.15 0.71 1.63 2.04E-07 6.80E-06 1.00E-10 2.58E-09 0.90 1 hsa-miR-24, [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase)(EC 3.2.2.19)(ADP-ribose-L-arginine cleaving enzyme) ADPRH ENSG00000144843 [Source:UniProtKB/Swiss-Prot;Acc:P54922] 5.54 6.25 0.71 1.63 1.15E-04 1.16E-03 3.80E-07 3.89E-06 1.06 3 hsa-miR-155,hsa-miR-424,hsa-miR-7, Sodium- and chloride-dependent glycine transporter 1 (GlyT1)(GlyT- 1)(Solute carrier family 6 member 9) [Source:UniProtKB/Swiss- SLC6A9 ENSG00000196517 Prot;Acc:P48067] 6.07 6.78 0.71 1.64 6.62E-05 7.37E-04 4.34E-10 9.40E-09 1.04 2 hsa-miR-222,hsa-miR-7, Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1)(GEF-H1)(Microtubule-regulated Rho- GEF)(Proliferating cell nucleolar antigen p40) ARHGEF2 ENSG00000116584 [Source:UniProtKB/Swiss-Prot;Acc:Q92974] 6.23 6.94 0.71 1.64 2.31E-04 2.05E-03 3.45E-05 2.25E-04 0.71 1 hsa-miR-7, Death effector domain-containing protein (DEDPro1)(Death effector domain-containing testicular molecule)(FLDED-1) DEDD ENSG00000158796 [Source:UniProtKB/Swiss-Prot;Acc:O75618] 6.95 7.66 0.71 1.64 9.05E-04 6.29E-03 1.27E-04 7.29E-04 0.71 2 hsa-miR-24,hsa-miR-7, Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small ANKRD46 ENSG00000186106 protein)(ANK-S) [Source:UniProtKB/Swiss-Prot;Acc:Q86W74] 6.03 6.75 0.71 1.64 1.47E-03 9.25E-03 3.53E-07 3.63E-06 1.14 1 hsa-miR-21, Disks large homolog 3 (Synapse-associated protein 102)(SAP102)(Neuroendocrine-DLG)(XLMR) DLG3 ENSG00000082458 [Source:UniProtKB/Swiss-Prot;Acc:Q92796] 6.19 6.91 0.71 1.64 1.62E-05 2.34E-04 2.67E-06 2.24E-05 0.71 2 hsa-miR-24,hsa-miR-7, Alpha-1,3-mannosyltransferase ALG2 (EC 2.4.1.-)(GDP- Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase)(Asparagine-linked glycosylation protein 2) ALG2 ENSG00000119523 [Source:UniProtKB/Swiss-Prot;Acc:Q9H553] 7.43 8.14 0.72 1.64 2.31E-05 3.12E-04 1.23E-05 8.92E-05 0.72 2 hsa-miR-19a,hsa-miR-7, DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4)(DNA-directed RNA polymerase III subunit D)(DNA- directed RNA polymerase III 47 kDa polypeptide)(RPC53)(Protein POLR3D ENSG00000168495 BN51) [Source:UniProtKB/Swiss-Prot;Acc:P05423] 6.45 7.17 0.72 1.64 4.60E-04 3.61E-03 5.15E-07 5.11E-06 0.93 3 hsa-miR-24,hsa-miR-424,hsa-miR-7, Pre-mRNA-processing factor 17 (PRP17 homolog)(hPRP17)(Cell division cycle 40 homolog)(EH-binding protein 3)(Ehb3) CDC40 ENSG00000168438 [Source:UniProtKB/Swiss-Prot;Acc:O60508] 6.87 7.59 0.72 1.65 1.57E-03 9.74E-03 2.77E-04 1.47E-03 0.72 1 hsa-miR-155, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein)(HMG box-containing protein 20B)(HMG domain-containing protein HMGX2)(HMG domain-containing protein 2)(Structural DNA- HMG20B ENSG00000064961 binding pr 6.61 7.33 0.72 1.65 4.28E-04 3.40E-03 3.62E-05 2.35E-04 0.83 1 hsa-miR-18a, Protein disulfide-isomerase A5 Precursor (EC 5.3.4.1)(Protein disulfide isomerase-related protein) [Source:UniProtKB/Swiss- PDIA5 ENSG00000065485 Prot;Acc:Q14554] 5.75 6.47 0.72 1.65 3.01E-07 9.22E-06 7.41E-15 6.33E-13 1.35 1 hsa-miR-27a, Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43)(Histone H3-K79 methyltransferase)(H3-K79- HMTase)(DOT1-like protein)(Lysine N-methyltransferase 4) DOT1L ENSG00000104885 [Source:UniProtKB/Swiss-Prot;Acc:Q8TEK3] 6.37 7.10 0.72 1.65 1.08E-05 1.69E-04 1.13E-08 1.68E-07 0.91 4 hsa-miR-200b,hsa-miR-210,hsa-miR-27a,hsa-miR-7, UPF0485 protein C1orf144 (Putative MAPK-activating protein C1orf144 ENSG00000055070 PM18/PM20/PM22) [Source:UniProtKB/Swiss-Prot;Acc:Q7Z422] 7.73 8.45 0.73 1.65 9.94E-04 6.75E-03 1.38E-04 7.83E-04 0.80 3 hsa-miR-24,hsa-miR-27a,hsa-miR-7, Protein FAM127A (Mammalian retrotransposon derived protein 8C) FAM127A ENSG00000134590 [Source:UniProtKB/Swiss-Prot;Acc:A6ZKI3] 6.56 7.28 0.73 1.66 2.22E-05 3.03E-04 5.87E-07 5.73E-06 0.98 1 hsa-miR-424, Uncharacterized protein C4orf16 [Source:UniProtKB/Swiss- C4orf16 ENSG00000138660 Prot;Acc:Q63HQ0] 6.61 7.35 0.74 1.66 2.80E-04 2.40E-03 2.86E-07 3.02E-06 0.92 1 hsa-miR-155, COMM domain-containing protein 4 [Source:UniProtKB/Swiss- COMMD4 ENSG00000140365 Prot;Acc:Q9H0A8] 7.25 7.99 0.74 1.67 1.81E-05 2.56E-04 1.26E-09 2.38E-08 1.23 1 hsa-miR-155, Ornithine decarboxylase antizyme 2 (ODC-Az 2)(AZ2) OAZ2 ENSG00000180304 [Source:UniProtKB/Swiss-Prot;Acc:O95190] 6.57 7.31 0.74 1.67 2.92E-05 3.77E-04 1.65E-05 1.16E-04 0.75 1 hsa-miR-365, Ras-related protein Rab-1B [Source:UniProtKB/Swiss- RAB1B ENSG00000174903 Prot;Acc:Q9H0U4] 7.56 8.30 0.74 1.67 2.16E-04 1.95E-03 5.67E-07 5.56E-06 1.06 4 hsa-miR-135b,hsa-miR-18a,hsa-miR-24,hsa-miR-365, Multidrug resistance-associated protein 1 (ATP-binding cassette sub- family C member 1)(Leukotriene C(4) transporter)(LTC4 transporter) ABCC1 ENSG00000103222 [Source:UniProtKB/Swiss-Prot;Acc:P33527] 6.86 7.61 0.74 1.67 1.31E-04 1.28E-03 1.03E-04 6.03E-04 0.74 2 hsa-miR-200b,hsa-miR-7, Probable RNA-binding protein 18 (RNA-binding motif protein 18) RBM18 ENSG00000119446 [Source:UniProtKB/Swiss-Prot;Acc:Q96H35] 6.95 7.69 0.74 1.67 1.55E-03 9.64E-03 9.28E-05 5.47E-04 0.77 2 hsa-miR-218,hsa-miR-221, Pyridoxal kinase (EC 2.7.1.35)(Pyridoxine kinase) PDXK ENSG00000160209 [Source:UniProtKB/Swiss-Prot;Acc:O00764] 6.61 7.36 0.74 1.68 2.27E-09 1.72E-07 3.69E-14 2.59E-12 1.04 3 hsa-miR-24,hsa-miR-27a,hsa-miR-7, ZNF621 ENSG00000172888 Zinc finger protein 621 [Source:UniProtKB/Swiss-Prot;Acc:Q6ZSS3] 5.98 6.73 0.75 1.68 6.51E-05 7.27E-04 2.13E-06 1.83E-05 0.75 3 hsa-miR-155,hsa-miR-18a,hsa-miR-7, Transcription factor E2F3 (E2F-3) [Source:UniProtKB/Swiss- E2F3 ENSG00000112242 Prot;Acc:O00716] 5.40 6.15 0.75 1.68 9.47E-04 6.52E-03 2.07E-07 2.27E-06 1.16 5 hsa-miR-155,hsa-miR-200b,hsa-miR-21,hsa-miR-210,hsa-miR-222, Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B- kinase beta)(IkBKB)(IKK-beta)(IKK-B)(EC 2.7.11.10)(I-kappa-B kinase 2)(IKK2)(Nuclear factor NF-kappa-B inhibitor kinase beta)(NFKBIKB) IKBKB ENSG00000104365 [Source:UniProtKB/Swiss-Prot;Acc:O14920] 7.07 7.82 0.75 1.68 1.63E-04 1.54E-03 1.91E-06 1.66E-05 0.77 1 hsa-miR-200b, Major facilitator superfamily domain-containing protein 2 MFSD2 ENSG00000168389 [Source:UniProtKB/Swiss-Prot;Acc:Q8NA29] 5.95 6.70 0.75 1.68 3.37E-05 4.23E-04 7.20E-10 1.47E-08 1.05 1 hsa-miR-27a,

AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha-1 subunit)(Adaptor protein complex AP-2 subunit alpha- 1)(Alpha1-adaptin)(Plasma membrane adaptor HA2/AP2 adaptin alpha AP2A1 ENSG00000196961 A subunit)(Alpha-adaptin A)(Clathrin assembly protein complex 2 al 6.39 7.14 0.75 1.69 3.67E-05 4.52E-04 1.89E-10 4.51E-09 1.13 1 hsa-miR-218, Tumor necrosis factor receptor superfamily member 10B Precursor (Death receptor 5)(TNF-related apoptosis-inducing ligand receptor 2)(TRAIL receptor 2)(TRAIL-R2)(CD262 antigen) TNFRSF10B ENSG00000120889 [Source:UniProtKB/Swiss-Prot;Acc:O14763] 6.34 7.09 0.76 1.69 6.18E-05 6.97E-04 1.61E-10 3.91E-09 1.33 2 hsa-miR-155,hsa-miR-24, 39S ribosomal protein L4, mitochondrial (L4mt)(MRP-L4) MRPL4 ENSG00000105364 [Source:UniProtKB/Swiss-Prot;Acc:Q9BYD3] 6.23 6.99 0.76 1.69 2.04E-06 4.41E-05 1.86E-13 1.07E-11 1.40 1 hsa-miR-24, OTU domain-containing protein 5 (EC 3.1.2.15)(Deubiquinating OTUD5 ENSG00000068308 enzyme A)(DUBA) [Source:UniProtKB/Swiss-Prot;Acc:Q96G74] 7.56 8.32 0.76 1.69 3.74E-04 3.05E-03 1.66E-05 1.16E-04 0.91 1 hsa-miR-24, Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated Src activator)(Protein FAM120A) FAM120A ENSG00000048828 [Source:UniProtKB/Swiss-Prot;Acc:Q9NZB2] 7.31 8.07 0.76 1.70 3.64E-04 2.98E-03 1.31E-05 9.42E-05 0.84 3 hsa-miR-221,hsa-miR-27a,hsa-miR-7, Cytosolic non-specific dipeptidase (CNDP dipeptidase 2)(Glutamate carboxypeptidase-like protein 1)(Peptidase A) CNDP2 ENSG00000133313 [Source:UniProtKB/Swiss-Prot;Acc:Q96KP4] 6.55 7.31 0.76 1.70 5.19E-04 4.00E-03 1.60E-07 1.81E-06 1.23 1 hsa-miR-218, Tumor necrosis factor receptor superfamily member 10D Precursor (Decoy receptor 2)(DcR2)(TNF-related apoptosis-inducing ligand receptor 4)(TRAIL receptor 4)(TRAIL-R4)(TRAIL receptor with a truncated death domain)(CD264 antigen) [Source:UniProtKB/Swiss- TNFRSF10D ENSG00000173530 Pro 6.23 7.00 0.77 1.70 4.90E-04 3.80E-03 4.39E-04 2.21E-03 0.85 1 hsa-miR-18a, Tetratricopeptide repeat protein 33 (TPR repeat protein 33)(Osmosis- TTC33 ENSG00000113638 responsive factor) [Source:UniProtKB/Swiss-Prot;Acc:Q6PID6] 6.11 6.88 0.77 1.71 8.06E-04 5.72E-03 8.20E-05 4.90E-04 0.77 1 hsa-miR-200b, Queuine tRNA-ribosyltransferase domain-containing protein 1 QTRTD1 ENSG00000151576 [Source:UniProtKB/Swiss-Prot;Acc:Q9H974] 6.45 7.23 0.77 1.71 2.15E-04 1.94E-03 3.99E-07 4.06E-06 1.24 2 hsa-miR-365,hsa-miR-7, Prostaglandin F2 receptor negative regulator Precursor (Prostaglandin F2-alpha receptor regulatory protein)(Prostaglandin F2-alpha receptor-associated protein)(CD9 partner 1)(CD9P-1)(Glu- Trp-Ile EWI motif-containing protein F)(EWI-F)(CD315 antigen) PTGFRN ENSG00000134247 [Sourc 5.90 6.67 0.77 1.71 3.78E-10 4.06E-08 5.01E-12 1.85E-10 1.15 6 hsa-miR-18a,hsa-miR-21,hsa-miR-24,hsa-miR-27a,hsa-miR-7,hsa-miR-93, Angio-associated migratory cell protein [Source:UniProtKB/Swiss- AAMP ENSG00000127837 Prot;Acc:Q13685] 7.19 7.97 0.77 1.71 2.32E-05 3.12E-04 1.42E-09 2.66E-08 1.20 1 hsa-miR-24, 28S ribosomal protein S25, mitochondrial (S25mt)(MRP-S25) MRPS25 ENSG00000131368 [Source:UniProtKB/Swiss-Prot;Acc:P82663] 6.10 6.87 0.77 1.71 2.47E-04 2.17E-03 2.00E-09 3.59E-08 1.42 3 hsa-miR-155,hsa-miR-18a,hsa-miR-200b, WD repeat-containing protein 35 [Source:UniProtKB/Swiss- WDR35 ENSG00000118965 Prot;Acc:Q9P2L0] 5.33 6.10 0.78 1.71 8.46E-04 5.96E-03 1.49E-09 2.78E-08 1.43 2 hsa-miR-222,hsa-miR-24, LMNB2 ENSG00000176619 Lamin-B2 [Source:UniProtKB/Swiss-Prot;Acc:Q03252] 6.11 6.89 0.78 1.72 1.55E-09 1.25E-07 3.00E-14 2.15E-12 0.83 2 hsa-miR-24,hsa-miR-7, Plasma alpha-L-fucosidase Precursor (EC 3.2.1.51)(Alpha-L-fucoside fucohydrolase 2)(Alpha-L-fucosidase 2) [Source:UniProtKB/Swiss- FUCA2 ENSG00000001036 Prot;Acc:Q9BTY2] 6.33 7.11 0.79 1.72 4.57E-05 5.43E-04 2.18E-05 1.49E-04 0.86 1 hsa-miR-222, Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) [Source:UniProtKB/Swiss- VKORC1L1 ENSG00000196715 Prot;Acc:Q8N0U8] 6.35 7.14 0.79 1.72 1.07E-06 2.58E-05 3.59E-12 1.38E-10 1.18 1 hsa-miR-222, Palmitoyltransferase ZDHHC18 (EC 2.3.1.-)(Zinc finger DHHC domain-containing protein 18)(DHHC-18) [Source:UniProtKB/Swiss- ZDHHC18 ENSG00000204160 Prot;Acc:Q9NUE0] 7.70 8.49 0.79 1.73 1.52E-04 1.46E-03 3.40E-06 2.79E-05 0.84 2 hsa-miR-19a,hsa-miR-24, 28S ribosomal protein S7, mitochondrial Precursor (S7mt)(MRP- S7)(bMRP-27a)(bMRP27a) [Source:UniProtKB/Swiss- MRPS7 ENSG00000125445 Prot;Acc:Q9Y2R9] 7.22 8.00 0.79 1.73 4.89E-04 3.79E-03 1.58E-08 2.27E-07 1.57 1 hsa-miR-221, REST corepressor 1 (Protein CoREST) [Source:UniProtKB/Swiss- RCOR1 ENSG00000089902 Prot;Acc:Q9UKL0] 6.77 7.55 0.79 1.73 5.37E-04 4.11E-03 7.51E-04 3.56E-03 0.79 4 hsa-miR-155,hsa-miR-18a,hsa-miR-19a,hsa-miR-218, TBC1 domain family member 9B [Source:UniProtKB/Swiss- TBC1D9B ENSG00000197226 Prot;Acc:Q66K14] 6.23 7.02 0.79 1.73 2.05E-04 1.86E-03 3.27E-05 2.14E-04 0.79 1 hsa-miR-155, F-box/WD repeat-containing protein 1A (F-box and WD repeats protein beta-TrCP)(E3RSIkappaB)(pIkappaBalpha-E3 receptor BTRC ENSG00000166167 subunit) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y297] 6.17 6.96 0.79 1.73 1.64E-04 1.55E-03 3.21E-06 2.65E-05 0.88 2 hsa-miR-132,hsa-miR-7, Pogo transposable element with KRAB domain POGK ENSG00000143157 [Source:UniProtKB/Swiss-Prot;Acc:Q9P215] 6.38 7.17 0.79 1.73 1.54E-03 9.60E-03 3.51E-06 2.87E-05 1.22 2 hsa-miR-135b,hsa-miR-7, Uncharacterized protein C11orf48 [Source:UniProtKB/Swiss- C11orf48 ENSG00000162194 Prot;Acc:Q9BQE6] 6.96 7.75 0.79 1.73 1.29E-04 1.27E-03 8.59E-10 1.70E-08 1.42 1 hsa-miR-7, Isochorismatase domain-containing protein 1 ISOC1 ENSG00000066583 [Source:UniProtKB/Swiss-Prot;Acc:Q96CN7] 6.57 7.36 0.80 1.74 1.85E-04 1.71E-03 3.63E-09 6.06E-08 1.38 1 hsa-miR-424, Trans-acting T-cell-specific transcription factor GATA-3 (GATA- GATA3 ENSG00000107485 binding factor 3) [Source:UniProtKB/Swiss-Prot;Acc:P23771] 7.11 7.91 0.80 1.74 1.28E-05 1.94E-04 1.57E-04 8.78E-04 0.80 2 hsa-miR-155,hsa-miR-27a, Sex comb on midleg-like protein 2 [Source:UniProtKB/Swiss- SCML2 ENSG00000102098 Prot;Acc:Q9UQR0] 4.66 5.45 0.80 1.74 8.16E-05 8.72E-04 3.86E-12 1.47E-10 1.55 4 hsa-miR-19a,hsa-miR-21,hsa-miR-24,hsa-miR-29b, RAB3A-interacting protein (Rabin-3)(SSX2-interacting protein) RAB3IP ENSG00000127328 [Source:UniProtKB/Swiss-Prot;Acc:Q96QF0] 6.36 7.16 0.80 1.74 6.76E-04 4.96E-03 2.75E-06 2.30E-05 1.21 4 hsa-miR-155,hsa-miR-24,hsa-miR-424,hsa-miR-7, CYCS ENSG00000172115 Cytochrome c [Source:UniProtKB/Swiss-Prot;Acc:P99999] 7.13 7.93 0.80 1.74 1.16E-03 7.69E-03 2.84E-08 3.82E-07 1.46 3 hsa-miR-221,hsa-miR-29b,hsa-miR-424, 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51)(1-acylglycerol-3-phosphate O-acyltransferase 5)(1-AGP acyltransferase 5)(1-AGPAT 5)(Lysophosphatidic acid acyltransferase epsilon)(LPAAT-epsilon) [Source:UniProtKB/Swiss- AGPAT5 ENSG00000155189 Prot;Acc:Q9NUQ2] 5.83 6.63 0.80 1.74 1.09E-05 1.70E-04 7.24E-07 6.91E-06 0.91 1 hsa-miR-19a, Dual specificity protein kinase CLK2 (EC 2.7.12.1)(CDC-like kinase 2) CLK2 ENSG00000176444 [Source:UniProtKB/Swiss-Prot;Acc:P49760] 7.67 8.47 0.80 1.74 6.17E-04 4.60E-03 2.51E-05 1.69E-04 0.87 1 hsa-miR-27a, Phospholipase A-2-activating protein (PLA2P)(PLAP) PLAA ENSG00000137055 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y263] 6.14 6.94 0.80 1.74 8.31E-05 8.85E-04 4.91E-09 7.90E-08 1.23 2 hsa-miR-19a,hsa-miR-27a, Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma- associated antigen 13)(NPC-A-13) [Source:UniProtKB/Swiss- HSBP1 ENSG00000230989 Prot;Acc:O75506] 6.25 7.06 0.81 1.75 7.68E-04 5.52E-03 1.67E-05 1.17E-04 1.36 1 hsa-miR-132, DNA topoisomerase 1 (EC 5.99.1.2)(DNA topoisomerase I) TOP1 ENSG00000198900 [Source:UniProtKB/Swiss-Prot;Acc:P11387] 6.65 7.46 0.81 1.75 1.18E-04 1.18E-03 4.23E-05 2.71E-04 0.84 1 hsa-miR-24, PANX1 ENSG00000110218 Pannexin-1 [Source:UniProtKB/Swiss-Prot;Acc:Q96RD7] 6.49 7.30 0.81 1.75 1.68E-04 1.58E-03 1.72E-06 1.51E-05 1.05 1 hsa-miR-218, Proteasome inhibitor PI31 subunit (hPI31) [Source:UniProtKB/Swiss- PSMF1 ENSG00000125818 Prot;Acc:Q92530] 7.46 8.28 0.81 1.75 6.34E-04 4.71E-03 8.08E-08 9.82E-07 1.16 1 hsa-miR-221, Palladin (Sarcoma antigen NY-SAR-77)(SIH002) PALLD ENSG00000129116 [Source:UniProtKB/Swiss-Prot;Acc:Q8WX93] 6.22 7.04 0.81 1.76 4.61E-07 1.30E-05 1.37E-08 1.99E-07 0.81 3 hsa-miR-155,hsa-miR-20b,hsa-miR-363, Dehydrodolichyl diphosphate synthase (Dedol-PP synthase)(EC 2.5.1.- DHDDS ENSG00000117682 ) [Source:UniProtKB/Swiss-Prot;Acc:Q86SQ9] 6.03 6.84 0.81 1.76 6.02E-04 4.51E-03 6.54E-10 1.35E-08 1.60 1 hsa-miR-7, Putative Polycomb group protein ASXL1 (Additional sex combs-like ASXL1 ENSG00000171456 protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q8IXJ9] 6.63 7.44 0.81 1.76 3.54E-04 2.91E-03 3.73E-04 1.91E-03 0.81 2 hsa-miR-155,hsa-miR-7, General transcription factor 3C polypeptide 4 (EC 2.3.1.48)(Transcription factor IIIC subunit delta)(TF3C-delta)(TFIIIC 90 kDa subunit)(TFIIIC 90) [Source:UniProtKB/Swiss- GTF3C4 ENSG00000125484 Prot;Acc:Q9UKN8] 6.36 7.17 0.81 1.76 6.11E-05 6.89E-04 2.94E-05 1.95E-04 0.87 1 hsa-miR-155, Uncharacterized protein C9orf97 [Source:UniProtKB/Swiss- C9orf97 ENSG00000136925 Prot;Acc:Q5T7W7] 5.90 6.71 0.82 1.76 7.20E-04 5.23E-03 8.11E-05 4.85E-04 0.84 3 hsa-miR-210,hsa-miR-365,hsa-miR-7, GTPase-activating protein and VPS9 domain-containing protein 1 (Rab5-activating protein 6)(GAPex-5) [Source:UniProtKB/Swiss- GAPVD1 ENSG00000165219 Prot;Acc:Q14C86] 6.64 7.45 0.82 1.76 1.60E-03 9.91E-03 8.35E-05 4.97E-04 1.10 3 hsa-miR-132,hsa-miR-218,hsa-miR-365, Mitochondrial inner membrane protease ATP23 homolog (EC 3.4.24.- )(XRCC6-binding protein 1)(Ku70-binding protein 3) XRCC6BP1 ENSG00000166896 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y6H3] 6.21 7.03 0.82 1.76 7.26E-05 7.95E-04 1.04E-05 7.67E-05 0.82 2 hsa-miR-27a,hsa-miR-7, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (Integrase interactor 1 protein)(hSNF5)(BAF47) [Source:UniProtKB/Swiss- SMARCB1 ENSG00000099956 Prot;Acc:Q12824] 6.64 7.46 0.82 1.76 4.51E-05 5.37E-04 2.30E-06 1.96E-05 0.87 1 hsa-miR-206, Histone-lysine N-methyltransferase SETD8 (EC 2.1.1.43)(H4-K20- HMTase SETD8)(SET domain-containing protein 8)(PR/SET domain- containing protein 07)(PR/SET07)(PR-Set7)(Lysine N- SETD8 ENSG00000183955 methyltransferase 5A) [Source:UniProtKB/Swiss-Prot;Acc:Q9NQR1] 7.00 7.82 0.82 1.76 5.47E-07 1.49E-05 2.51E-08 3.43E-07 0.85 2 hsa-miR-18a,hsa-miR-7, Protein C16orf88 (Testis-specific gene 118 protein) C16orf88 ENSG00000103550 [Source:UniProtKB/Swiss-Prot;Acc:Q1ED39] 6.24 7.06 0.82 1.76 3.13E-04 2.63E-03 5.46E-08 6.93E-07 1.31 1 hsa-miR-135b, CALM3 ENSG00000160014 Calmodulin (CaM) [Source:UniProtKB/Swiss-Prot;Acc:P62158] 8.84 9.66 0.82 1.76 4.94E-04 3.83E-03 3.14E-06 2.60E-05 0.93 2 hsa-miR-27a,hsa-miR-7, Low-density lipoprotein receptor-related protein 12 Precursor (Suppressor of tumorigenicity protein 7) [Source:UniProtKB/Swiss- LRP12 ENSG00000147650 Prot;Acc:Q9Y561] 4.77 5.59 0.82 1.77 2.70E-04 2.33E-03 1.52E-07 1.73E-06 1.26 2 hsa-miR-155,hsa-miR-19a, AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A)(Dead ringer-like protein 1)(B-cell regulator of IgH transcription)(Bright)(E2F-binding protein 1) ARID3A ENSG00000116017 [Source:UniProtKB/Swiss-Prot;Acc:Q99856] 5.74 6.56 0.82 1.77 6.88E-08 2.79E-06 1.54E-07 1.75E-06 0.82 1 hsa-let-7f, SEC14L1 ENSG00000129657 SEC14-like protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q92503] 6.90 7.72 0.82 1.77 1.78E-06 3.94E-05 2.62E-07 2.80E-06 0.82 1 hsa-miR-218, Insulin-induced gene 1 protein (INSIG-1) [Source:UniProtKB/Swiss- hsa-miR-155,hsa-miR-19a,hsa-miR-210,hsa-miR-218,hsa-miR-222,hsa-miR-24,hsa- INSIG1 ENSG00000186480 Prot;Acc:O15503] 7.26 8.09 0.83 1.77 4.22E-04 3.36E-03 5.30E-09 8.46E-08 1.36 7 miR-7, Bifunctional UDP-N-acetylglucosamine 2-epimerase/N- acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes UDP-N-acetylglucosamine 2-epimerase(EC 5.1.3.14)(Uridine diphosphate-N-acetylglucosamine-2- GNE ENSG00000159921 epimerase)(UDP-GlcNAc-2-epimerase);N-ace 6.03 6.86 0.83 1.78 9.23E-05 9.64E-04 6.62E-07 6.39E-06 1.06 3 hsa-miR-155,hsa-miR-24,hsa-miR-7, Protein RRP5 homolog (Programmed cell death protein 11)(NF- kappa-B-binding protein)(NFBP) [Source:UniProtKB/Swiss- PDCD11 ENSG00000148843 Prot;Acc:Q14690] 5.69 6.52 0.83 1.78 2.66E-05 3.49E-04 6.12E-09 9.64E-08 1.17 1 hsa-miR-7, Large proline-rich protein BAT3 (HLA-B-associated transcript BAT3 ENSG00000204463 3)(Protein G3) [Source:UniProtKB/Swiss-Prot;Acc:P46379] 7.49 8.32 0.83 1.78 1.93E-05 2.70E-04 3.80E-07 3.89E-06 0.84 1 hsa-miR-200b, Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3)(MAPKK 3)(EC 2.7.12.2)(MAPK/ERK kinase 3) MAP2K3 ENSG00000034152 [Source:UniProtKB/Swiss-Prot;Acc:P46734] 6.53 7.36 0.83 1.78 1.15E-08 6.54E-07 7.31E-14 4.73E-12 1.23 2 hsa-miR-19b,hsa-miR-21, Tetraspanin-3 (Tspan-3)(Transmembrane 4 superfamily member TSPAN3 ENSG00000140391 8)(Tetraspanin TM4-A) [Source:UniProtKB/Swiss-Prot;Acc:O60637] 7.47 8.31 0.83 1.78 2.15E-04 1.94E-03 7.17E-10 1.46E-08 1.71 1 hsa-miR-218, DNA-binding protein SATB1 (Special AT-rich sequence-binding SATB1 ENSG00000182568 protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q01826] 8.55 9.38 0.83 1.78 5.63E-04 4.28E-03 6.23E-04 3.02E-03 0.83 4 hsa-miR-155,hsa-miR-19a,hsa-miR-21,hsa-miR-7, Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha- SEC61A2 ENSG00000065665 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9H9S3] 6.04 6.87 0.83 1.78 7.07E-06 1.19E-04 1.37E-08 1.99E-07 0.98 1 hsa-miR-155, Plastin-1 (Intestine-specific plastin)(I-plastin) PLS1 ENSG00000120756 [Source:UniProtKB/Swiss-Prot;Acc:Q14651] 5.43 6.26 0.83 1.78 7.03E-05 7.72E-04 4.55E-09 7.39E-08 1.32 5 hsa-miR-132,hsa-miR-155,hsa-miR-19a,hsa-miR-27a,hsa-miR-7, Alpha-1,6-mannosyl-glycoprotein 2-beta-N- acetylglucosaminyltransferase (EC 2.4.1.143)(Mannoside acetylglucosaminyltransferase 2)(N-glycosyl-oligosaccharide- glycoprotein N-acetylglucosaminyltransferase II)(Beta-1,2-N- MGAT2 ENSG00000168282 acetylglucosaminyltransferase II)(GlcNA 6.74 7.58 0.84 1.78 3.05E-04 2.58E-03 2.88E-05 1.91E-04 0.84 2 hsa-miR-155,hsa-miR-200b, Smith-Magenis syndrome chromosome region candidate gene 7 SMCR7L ENSG00000100335 protein-like [Source:UniProtKB/Swiss-Prot;Acc:Q9NQG6] 5.73 6.56 0.84 1.79 1.20E-06 2.85E-05 6.12E-10 1.27E-08 1.11 1 hsa-miR-132, Progressive ankylosis protein homolog (ANK) ANKH ENSG00000154122 [Source:UniProtKB/Swiss-Prot;Acc:Q9HCJ1] 7.09 7.92 0.84 1.79 1.44E-04 1.40E-03 2.24E-05 1.52E-04 0.85 4 hsa-miR-155,hsa-miR-18a,hsa-miR-200b,hsa-miR-7, Serine/threonine-protein kinase 3 (EC 2.7.11.1)(STE20-like kinase MST2)(MST-2)(Mammalian STE20-like protein kinase 2)(Serine/threonine-protein kinase Krs-1) [Source:UniProtKB/Swiss- STK3 ENSG00000104375 Prot;Acc:Q13188] 5.14 5.98 0.84 1.79 7.12E-05 7.82E-04 6.77E-08 8.42E-07 1.23 1 hsa-miR-21, Thyroid receptor-interacting protein 6 (TRIP-6)(OPA-interacting protein 1)(Zyxin-related protein 1)(ZRP-1) [Source:UniProtKB/Swiss- TRIP6 ENSG00000087077 Prot;Acc:Q15654] 6.41 7.24 0.84 1.79 2.29E-11 4.26E-09 1.50E-16 2.13E-14 0.96 1 hsa-miR-7,

Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta POLDIP3 ENSG00000100227 interaction protein)(p46) [Source:UniProtKB/Swiss-Prot;Acc:Q9BY77] 7.37 8.21 0.84 1.79 1.35E-03 8.66E-03 6.15E-04 2.99E-03 0.84 2 hsa-miR-155,hsa-miR-365, Nuclear receptor-binding factor 2 (NRBF-2)(Comodulator of PPAR NRBF2 ENSG00000148572 and RXR) [Source:UniProtKB/Swiss-Prot;Acc:Q96F24] 7.59 8.43 0.84 1.79 4.60E-04 3.61E-03 9.55E-05 5.61E-04 0.84 3 hsa-miR-19a,hsa-miR-200b,hsa-miR-27a, AP-4 complex subunit epsilon-1 (Adapter-related protein complex 4 subunit epsilon-1)(AP-4 adapter complex subunit epsilon)(Epsilon subunit of AP-4)(Epsilon-adaptin) [Source:UniProtKB/Swiss- AP4E1 ENSG00000081014 Prot;Acc:Q9UPM8] 6.11 6.95 0.84 1.79 7.19E-04 5.23E-03 1.16E-05 8.44E-05 0.97 3 hsa-let-7f,hsa-miR-155,hsa-miR-21, Fanconi anemia group C protein (Protein FACC) FANCC ENSG00000158169 [Source:UniProtKB/Swiss-Prot;Acc:Q00597] 5.58 6.42 0.84 1.79 7.41E-09 4.54E-07 2.71E-13 1.47E-11 1.06 1 hsa-miR-24, Pendrin (Sodium-independent chloride/iodide transporter)(Solute carrier family 26 member 4) [Source:UniProtKB/Swiss- SLC26A4 ENSG00000091137 Prot;Acc:O43511] 5.42 6.26 0.84 1.79 9.18E-05 9.60E-04 3.06E-09 5.23E-08 1.20 2 hsa-miR-18a,hsa-miR-19a, Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41)(Polypeptide GalNAc transferase 2)(pp-GaNTase 2)(GalNAc- T2)(Protein-UDP acetylgalactosaminyltransferase 2)(UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Contains GALNT2 ENSG00000143641 Polypeptide N-ace 7.01 7.85 0.84 1.79 6.82E-08 2.77E-06 8.48E-09 1.30E-07 0.90 2 hsa-miR-200b,hsa-miR-7, Cytochrome b5 domain-containing protein 1 CYB5D1 ENSG00000182224 [Source:UniProtKB/Swiss-Prot;Acc:Q6P9G0] 5.89 6.73 0.84 1.79 8.64E-05 9.12E-04 8.75E-09 1.33E-07 1.17 1 hsa-miR-7, CAP-Gly domain-containing linker protein 1 (Restin)(Cytoplasmic linker protein 170 alpha-2)(CLIP-170)(Reed-Sternberg intermediate filament-associated protein)(Cytoplasmic linker protein 1) CLIP1 ENSG00000130779 [Source:UniProtKB/Swiss-Prot;Acc:P30622] 6.56 7.41 0.84 1.79 5.65E-05 6.46E-04 1.67E-06 1.47E-05 0.86 4 hsa-miR-130b,hsa-miR-19a,hsa-miR-200b,hsa-miR-7, SET-binding protein (SEB) [Source:UniProtKB/Swiss- SETBP1 ENSG00000152217 Prot;Acc:Q9Y6X0] 5.92 6.76 0.85 1.80 3.06E-08 1.44E-06 5.13E-09 8.21E-08 0.85 1 hsa-miR-24, FAM36A ENSG00000203667 Protein FAM36A [Source:UniProtKB/Swiss-Prot;Acc:Q5RI15] 6.81 7.66 0.85 1.80 8.36E-04 5.89E-03 2.85E-07 3.01E-06 1.14 1 hsa-miR-7, Probable ergosterol biosynthetic protein 28 [Source:UniProtKB/Swiss- C14orf1 ENSG00000133935 Prot;Acc:Q9UKR5] 7.73 8.57 0.85 1.80 3.43E-04 2.84E-03 3.19E-10 7.15E-09 1.77 3 hsa-miR-155,hsa-miR-24,hsa-miR-7, CD151 antigen (Platelet-endothelial tetraspan antigen 3)(PETA- 3)(GP27)(Membrane glycoprotein SFA-1)(Tetraspanin-24)(Tspan- CD151 ENSG00000177697 24)(CD151 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P48509] 6.18 7.03 0.85 1.80 1.48E-04 1.42E-03 2.08E-06 1.79E-05 1.02 1 hsa-miR-7, Zinc finger protein Eos (Ikaros family zinc finger protein 4) IKZF4 ENSG00000123411 [Source:UniProtKB/Swiss-Prot;Acc:Q9H2S9] 5.43 6.28 0.85 1.80 3.82E-07 1.11E-05 4.47E-11 1.27E-09 1.07 3 hsa-miR-221,hsa-miR-365,hsa-miR-7, Phosphatidylcholine transfer protein (PC-TP)(StAR-related lipid transfer protein 2)(START domain-containing protein 2)(StARD2) PCTP ENSG00000141179 [Source:UniProtKB/Swiss-Prot;Acc:Q9UKL6] 5.84 6.69 0.85 1.80 5.08E-06 9.18E-05 1.70E-08 2.42E-07 1.04 2 hsa-let-7f,hsa-miR-7, Sperm-associated antigen 7 [Source:UniProtKB/Swiss- SPAG7 ENSG00000091640 Prot;Acc:O75391] 6.08 6.93 0.85 1.81 1.50E-04 1.44E-03 1.13E-08 1.67E-07 1.39 1 hsa-miR-424, T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1) TIAM1 ENSG00000156299 [Source:UniProtKB/Swiss-Prot;Acc:Q13009] 6.01 6.86 0.85 1.81 4.92E-05 5.76E-04 7.95E-06 6.00E-05 0.85 5 hsa-miR-19a,hsa-miR-21,hsa-miR-222,hsa-miR-29b,hsa-miR-7, Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) HSPA8 ENSG00000109971 [Source:UniProtKB/Swiss-Prot;Acc:P11142] 10.33 11.19 0.86 1.81 4.46E-04 3.51E-03 3.43E-08 4.54E-07 1.36 1 hsa-miR-365, Oxysterol-binding protein-related protein 3 (OSBP-related protein OSBPL3 ENSG00000070882 3)(ORP-3) [Source:UniProtKB/Swiss-Prot;Acc:Q9H4L5] 6.55 7.41 0.86 1.81 8.29E-05 8.83E-04 8.09E-06 6.10E-05 0.91 4 hsa-miR-155,hsa-miR-21,hsa-miR-222,hsa-miR-7, Integral membrane protein GPR137B (Transmembrane 7 superfamily GPR137B ENSG00000077585 member 1 protein) [Source:UniProtKB/Swiss-Prot;Acc:O60478] 6.10 6.95 0.86 1.81 2.68E-05 3.51E-04 4.44E-05 2.84E-04 0.86 1 hsa-miR-19a, AFG3-like protein 2 (EC 3.4.24.-)(Paraplegin-like protein) AFG3L2 ENSG00000141385 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y4W6] 6.08 6.93 0.86 1.81 9.00E-05 9.44E-04 3.44E-09 5.79E-08 1.37 1 hsa-miR-27a, Twisted gastrulation protein homolog 1 Precursor TWSG1 ENSG00000128791 [Source:UniProtKB/Swiss-Prot;Acc:Q9GZX9] 5.96 6.82 0.86 1.82 3.36E-05 4.22E-04 7.00E-09 1.09E-07 1.19 1 hsa-miR-7, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) [Source:UniProtKB/Swiss- GNB1 ENSG00000078369 Prot;Acc:P62873] 8.57 9.43 0.86 1.82 9.66E-04 6.61E-03 2.66E-05 1.78E-04 0.95 2 hsa-miR-218,hsa-miR-222, Protein Jumonji (Jumonji/ARID domain-containing protein 2) JARID2 ENSG00000008083 [Source:UniProtKB/Swiss-Prot;Acc:Q92833] 6.36 7.23 0.86 1.82 5.82E-06 1.02E-04 4.11E-07 4.16E-06 0.86 2 hsa-miR-155,hsa-miR-19a, Histone demethylase JARID1C (EC 1.14.11.-)(Jumonji/ARID domain- containing protein 1C)(Protein SmcX)(Protein Xe169) JARID1C ENSG00000126012 [Source:UniProtKB/Swiss-Prot;Acc:P41229] 7.40 8.26 0.87 1.82 1.28E-03 8.32E-03 7.96E-04 3.76E-03 0.87 2 hsa-miR-132,hsa-miR-24, DNA polymerase sigma (EC 2.7.7.7)(Topoisomerase-related function protein 4-1)(TRF4-1)(LAK-1)(DNA polymerase kappa) POLS ENSG00000112941 [Source:UniProtKB/Swiss-Prot;Acc:Q5XG87] 6.82 7.68 0.87 1.82 1.15E-04 1.16E-03 1.40E-04 7.94E-04 0.87 1 hsa-miR-27a, Collagen alpha-3(VI) chain Precursor [Source:UniProtKB/Swiss- COL6A3 ENSG00000163359 Prot;Acc:P12111] 6.06 6.93 0.87 1.82 2.36E-07 7.61E-06 7.87E-10 1.58E-08 0.87 1 hsa-miR-130b, RNF24 ENSG00000101236 RING finger protein 24 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y225] 6.38 7.25 0.87 1.82 3.31E-07 9.89E-06 6.97E-07 6.68E-06 0.87 1 hsa-miR-132, Serine incorporator 3 (Tumor differentially expressed protein 1) SERINC3 ENSG00000132824 [Source:UniProtKB/Swiss-Prot;Acc:Q13530] 8.11 8.98 0.87 1.83 4.87E-04 3.78E-03 9.55E-05 5.61E-04 0.87 1 hsa-miR-19a, FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1)(FHOS)(Formin homology 2 domain- FHOD1 ENSG00000135723 containing protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y613] 6.05 6.92 0.87 1.83 1.48E-06 3.41E-05 2.78E-09 4.80E-08 1.04 1 hsa-miR-200b, Thioredoxin, mitochondrial Precursor (Mt-Trx)(MTRX)(Thioredoxin- TXN2 ENSG00000100348 2) [Source:UniProtKB/Swiss-Prot;Acc:Q99757] 6.98 7.86 0.88 1.83 1.02E-07 3.84E-06 6.02E-10 1.25E-08 0.96 2 hsa-miR-27b,hsa-miR-7, Alpha-1,3-mannosyl-glycoprotein 2-beta-N- acetylglucosaminyltransferase (EC 2.4.1.101)(N-glycosyl- oligosaccharide-glycoprotein N-acetylglucosaminyltransferase MGAT1 ENSG00000131446 I)(GlcNAc-T I)(GNT-I) [Source:UniProtKB/Swiss-Prot;Acc:P26572] 6.83 7.70 0.88 1.84 1.22E-04 1.21E-03 5.56E-05 3.47E-04 0.88 1 hsa-miR-7, Transmembrane protein 128 [Source:UniProtKB/Swiss- TMEM128 ENSG00000132406 Prot;Acc:Q5BJH2] 6.46 7.34 0.88 1.84 1.01E-03 6.86E-03 1.38E-05 9.84E-05 1.09 1 hsa-miR-7, Transitional endoplasmic reticulum ATPase (TER ATPase)(15S Mg(2+)-ATPase p97 subunit)(Valosin-containing protein)(VCP) VCP ENSG00000165280 [Source:UniProtKB/Swiss-Prot;Acc:P55072] 7.98 8.86 0.88 1.84 3.09E-04 2.60E-03 7.69E-11 2.04E-09 1.81 1 hsa-miR-7, Transmembrane emp24 domain-containing protein 2 Precursor (Membrane protein p24A) [Source:UniProtKB/Swiss- TMED2 ENSG00000086598 Prot;Acc:Q15363] 9.49 10.37 0.88 1.84 1.02E-03 6.92E-03 2.79E-07 2.96E-06 1.17 1 hsa-miR-155, Far upstream element-binding protein 2 (FUSE-binding protein 2)(KH type-splicing regulatory protein)(KSRP)(p75) KHSRP ENSG00000088247 [Source:UniProtKB/Swiss-Prot;Acc:Q92945] 6.19 7.07 0.88 1.85 2.81E-06 5.70E-05 5.21E-10 1.10E-08 1.20 1 hsa-miR-27a, FAD-dependent oxidoreductase domain-containing protein 1 FOXRED1 ENSG00000110074 [Source:UniProtKB/Swiss-Prot;Acc:Q96CU9] 5.57 6.46 0.88 1.85 2.33E-06 4.88E-05 4.72E-14 3.17E-12 1.74 1 hsa-miR-424, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform)(PP2A, B subunit, B56 delta isoform)(PP2A, B subunit, PR61 delta isoform)(PP2A, B PPP2R5D ENSG00000112640 subunit, R5 delta isoform) [Source:UniProtKB/Swiss-Prot;Ac 6.81 7.70 0.88 1.85 1.04E-04 1.06E-03 1.06E-05 7.79E-05 0.88 1 hsa-miR-218, BCL-6 corepressor (BCoR) [Source:UniProtKB/Swiss- BCOR ENSG00000183337 Prot;Acc:Q6W2J9] 6.61 7.49 0.88 1.85 2.82E-04 2.42E-03 6.41E-06 4.94E-05 1.12 1 hsa-miR-27a, Putative hydrolase RBBP9 (EC 3.-.-.-)(Retinoblastoma-binding protein 9)(RBBP-9)(Retinoblastoma-binding protein 10)(RBBP- 10)(B5T overexpressed gene protein)(Protein BOG) RBBP9 ENSG00000089050 [Source:UniProtKB/Swiss-Prot;Acc:O75884] 6.38 7.26 0.89 1.85 2.22E-04 1.99E-03 1.29E-07 1.49E-06 1.28 1 hsa-miR-7, DnaJ homolog subfamily C member 14 (Dopamine receptor- interacting protein of 78 kDa)(DRiP78)(DnaJ protein homolog DNAJC14 ENSG00000135392 3)(HDJ-3) [Source:UniProtKB/Swiss-Prot;Acc:Q6Y2X3] 6.19 7.08 0.89 1.85 3.40E-05 4.26E-04 4.77E-09 7.70E-08 1.23 1 hsa-miR-222, Putative ribosomal RNA methyltransferase 2 (EC 2.1.1.-)(rRNA (uridine-2'-O-)-methyltransferase) [Source:UniProtKB/Swiss- FTSJ2 ENSG00000122687 Prot;Acc:Q9UI43] 6.29 7.18 0.89 1.85 3.88E-07 1.13E-05 2.37E-13 1.31E-11 1.34 2 hsa-miR-21,hsa-miR-210, Calumenin Precursor (Crocalbin)(IEF SSP 9302) CALU ENSG00000128595 [Source:UniProtKB/Swiss-Prot;Acc:O43852] 5.75 6.64 0.89 1.85 1.14E-03 7.54E-03 8.94E-08 1.08E-06 1.42 5 hsa-miR-155,hsa-miR-200b,hsa-miR-218,hsa-miR-27a,hsa-miR-7, 24-dehydrocholesterol reductase Precursor (EC 1.3.1.-)(3-beta- hydroxysterol delta-24-reductase)(Seladin-1)(Diminuto/dwarf1 DHCR24 ENSG00000116133 homolog) [Source:UniProtKB/Swiss-Prot;Acc:Q15392] 6.01 6.90 0.89 1.85 1.68E-05 2.41E-04 4.02E-16 4.97E-14 2.24 1 hsa-miR-24, WD repeat-containing protein 32 [Source:UniProtKB/Swiss- WDR32 ENSG00000122741 Prot;Acc:Q5QP82] 6.54 7.43 0.89 1.86 6.74E-04 4.96E-03 5.90E-04 2.88E-03 0.89 5 hsa-miR-155,hsa-miR-18a,hsa-miR-21,hsa-miR-218,hsa-miR-365, Glycerol-3-phosphate acyltransferase 4 Precursor (GPAT4)(EC 2.3.1.15)(Acyl-CoA:glycerol-3-phosphate acyltransferase 4)(1- acylglycerol-3-phosphate O-acyltransferase 6)(1-AGP acyltransferase 6)(1-AGPAT 6)(Lysophosphatidic acid acyltransferase zeta)(LPAAT- AGPAT6 ENSG00000158669 ze 6.96 7.85 0.89 1.86 1.19E-04 1.19E-03 7.71E-05 4.64E-04 0.89 1 hsa-miR-424, H1FX ENSG00000184897 Histone H1x [Source:UniProtKB/Swiss-Prot;Acc:Q92522] 6.66 7.56 0.89 1.86 1.67E-04 1.57E-03 3.93E-06 3.18E-05 0.90 1 hsa-miR-24, Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22)(CDC2- related protein kinase 6)(Death-preventing kinase)(Cyclin-dependent CDC2L6 ENSG00000155111 kinase 11) [Source:UniProtKB/Swiss-Prot;Acc:Q9BWU1] 6.64 7.53 0.89 1.86 5.19E-04 3.99E-03 3.08E-04 1.61E-03 0.89 5 hsa-miR-18a,hsa-miR-19a,hsa-miR-200b,hsa-miR-221,hsa-miR-7, Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial Precursor (EC 1.2.4.2)(Dehydrogenase E1 and transketolase domain-containing protein 1) [Source:UniProtKB/Swiss- DHTKD1 ENSG00000181192 Prot;Acc:Q96HY7] 5.61 6.50 0.89 1.86 2.96E-05 3.81E-04 4.49E-06 3.59E-05 0.89 1 hsa-miR-218, Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q)(Vasculogenesis gene on 5q protein)(hVG5Q)(G patch domain-containing protein 7) [Source:UniProtKB/Swiss- AGGF1 ENSG00000164252 Prot;Acc:Q8N302] 5.60 6.50 0.89 1.86 4.41E-04 3.49E-03 2.02E-06 1.74E-05 1.12 1 hsa-miR-27a, Activin receptor type-1 Precursor (EC 2.7.11.30)(Activin receptor type I)(ACTR-I)(Serine/threonine-protein kinase receptor R1)(SKR1)(Activin receptor-like kinase 2)(ALK-2)(TGF-B superfamily ACVR1 ENSG00000115170 receptor type I)(TSR-I) [Source:UniProtKB/Swiss-Prot;Acc:Q04771] 6.34 7.23 0.89 1.86 8.52E-05 9.03E-04 1.14E-05 8.36E-05 0.89 3 hsa-miR-130b,hsa-miR-155,hsa-miR-365, Ras-related C3 botulinum toxin substrate 1 Precursor (p21- Rac1)(Ras-like protein TC25)(Cell migration-inducing gene 5 RAC1 ENSG00000136238 protein) [Source:UniProtKB/Swiss-Prot;Acc:P63000] 8.00 8.89 0.90 1.86 4.62E-04 3.62E-03 5.79E-06 4.51E-05 1.20 3 hsa-miR-155,hsa-miR-200b,hsa-miR-365, ZNF692 ENSG00000171163 Zinc finger protein 692 [Source:UniProtKB/Swiss-Prot;Acc:Q9BU19] 6.39 7.28 0.90 1.86 1.29E-03 8.35E-03 6.55E-05 4.01E-04 1.02 1 hsa-miR-7, Low-density lipoprotein receptor-related protein 8 Precursor (Apolipoprotein E receptor 2) [Source:UniProtKB/Swiss- LRP8 ENSG00000157193 Prot;Acc:Q14114] 5.85 6.74 0.90 1.86 9.32E-08 3.55E-06 5.47E-17 8.90E-15 1.87 1 hsa-miR-130b, ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6- interacting protein 1)(Aip-1) [Source:UniProtKB/Swiss- ARL6IP1 ENSG00000170540 Prot;Acc:Q15041] 9.83 10.73 0.90 1.86 7.02E-04 5.12E-03 1.17E-05 8.48E-05 0.90 3 hsa-miR-130b,hsa-miR-222,hsa-miR-7, Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97)(Peptide N- myristoyltransferase 1)(Myristoyl-CoA:protein N-myristoyltransferase 1)(NMT 1)(Type I N-myristoyltransferase) [Source:UniProtKB/Swiss- NMT1 ENSG00000136448 Prot;Acc:P30419] 6.82 7.71 0.90 1.86 1.89E-04 1.74E-03 1.00E-06 9.25E-06 1.17 1 hsa-miR-7, Polyadenylate-binding protein-interacting protein 1 (Poly(A)-binding protein-interacting protein 1)(PABP-interacting protein 1)(PAIP-1) PAIP1 ENSG00000172239 [Source:UniProtKB/Swiss-Prot;Acc:Q9H074] 7.04 7.94 0.90 1.86 1.61E-03 9.91E-03 1.09E-04 6.33E-04 1.04 1 hsa-miR-221, Hcp beta-lactamase-like protein C1orf163 [Source:UniProtKB/Swiss- C1orf163 ENSG00000162377 Prot;Acc:Q96BR5] 4.82 5.72 0.90 1.86 6.24E-07 1.66E-05 5.28E-17 8.63E-15 2.07 2 hsa-miR-24,hsa-miR-27a, Zinc finger CCHC domain-containing protein 4 ZCCHC4 ENSG00000168228 [Source:UniProtKB/Swiss-Prot;Acc:Q9H5U6] 6.43 7.33 0.90 1.87 1.53E-04 1.46E-03 5.22E-06 4.13E-05 0.90 1 hsa-miR-18a,

Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains NF1 ENSG00000196712 Neurofibromin truncated] [Source:UniProtKB/Swiss-Prot;Acc:P21359] 6.05 6.95 0.90 1.87 3.38E-04 2.80E-03 8.75E-05 5.19E-04 0.90 3 hsa-miR-135b,hsa-miR-27a,hsa-miR-7, Uncharacterized protein C2orf48 [Source:UniProtKB/Swiss- C2orf48 ENSG00000163009 Prot;Acc:Q96LS8] 5.99 6.90 0.90 1.87 3.70E-06 7.13E-05 3.40E-07 3.52E-06 0.90 1 hsa-miR-155, N-acetyltransferase 13 (EC 2.3.1.-)(N-acetyltransferase 5)(hNAT5)(N-acetyltransferase san homolog)(hSAN) NAT13 ENSG00000121579 [Source:UniProtKB/Swiss-Prot;Acc:Q9GZZ1] 7.31 8.21 0.91 1.88 1.25E-04 1.23E-03 1.45E-09 2.71E-08 1.57 5 hsa-miR-130b,hsa-miR-155,hsa-miR-18a,hsa-miR-27a,hsa-miR-365, Probable D-tyrosyl-tRNA(Tyr) deacylase 2 (EC 3.1.-.-) C14orf126 ENSG00000129480 [Source:UniProtKB/Swiss-Prot;Acc:Q96FN9] 5.83 6.74 0.91 1.88 1.83E-04 1.69E-03 8.39E-08 1.02E-06 1.35 1 hsa-miR-221, Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2)(TWIK-related acid-sensitive K(+) channel 2) KCNK5 ENSG00000164626 [Source:UniProtKB/Swiss-Prot;Acc:O95279] 6.12 7.04 0.91 1.88 3.89E-09 2.66E-07 2.30E-12 9.31E-11 1.22 2 hsa-miR-210,hsa-miR-27a, Serpin B8 (Cytoplasmic antiproteinase 2)(CAP-2)(CAP2)(Proteinase SERPINB8 ENSG00000166401 inhibitor 8) [Source:UniProtKB/Swiss-Prot;Acc:P50452] 6.45 7.36 0.91 1.89 3.65E-05 4.50E-04 4.33E-07 4.37E-06 1.10 1 hsa-miR-7, Amyloid beta A4 protein Precursor (Alzheimer disease amyloid protein)(ABPP)(APPI)(APP)(PreA4)(Cerebral vascular amyloid peptide)(CVAP)(Protease nexin-II)(PN-II) [Contains Soluble APP- alpha(S-APP-alpha);Soluble APP-beta(S-APP-beta);C99;Beta- APP ENSG00000142192 amyloid protein 6.68 7.60 0.92 1.89 5.85E-04 4.41E-03 2.12E-06 1.83E-05 1.31 1 hsa-miR-424, NFX1-type zinc finger-containing protein 1 [Source:UniProtKB/Swiss- ZNFX1 ENSG00000124201 Prot;Acc:Q9P2E3] 7.02 7.93 0.92 1.89 2.57E-04 2.23E-03 6.11E-05 3.77E-04 0.92 1 hsa-miR-218, Sphingomyelin synthase-related protein 1 (SMSr)(Sterile alpha motif SAMD8 ENSG00000156671 domain-containing 8) [Source:UniProtKB/Swiss-Prot;Acc:Q96LT4] 8.09 9.01 0.92 1.89 1.42E-04 1.38E-03 2.81E-05 1.87E-04 0.92 1 hsa-miR-19a, Fibroblast growth factor 11 (FGF-11)(Fibroblast growth factor homologous factor 3)(FHF-3) [Source:UniProtKB/Swiss- FGF11 ENSG00000161958 Prot;Acc:Q92914] 6.51 7.43 0.92 1.89 1.37E-05 2.04E-04 4.97E-05 3.14E-04 0.92 3 hsa-miR-24,hsa-miR-7,hsa-miR-98, Charged multivesicular body protein 4b (Chromatin-modifying protein 4b)(CHMP4b)(Vacuolar protein-sorting-associated protein 32- 2)(Vps32-2)(hVps32-2)(SNF7-2)(hSnf7-2)(SNF7 homolog CHMP4B ENSG00000101421 associated with Alix 1) [Source:UniProtKB/Swiss-Prot;Acc:Q9H444] 7.15 8.06 0.92 1.89 1.62E-04 1.54E-03 3.52E-05 2.29E-04 0.92 2 hsa-miR-19b,hsa-miR-221, PDZ and LIM domain protein 7 (LIM mineralization protein)(LMP)(Protein enigma) [Source:UniProtKB/Swiss- PDLIM7 ENSG00000196923 Prot;Acc:Q9NR12] 6.12 7.04 0.92 1.89 7.14E-11 1.06E-08 5.04E-10 1.07E-08 0.92 1 hsa-miR-24, Uncharacterized protein KIAA0586 [Source:UniProtKB/Swiss- KIAA0586 ENSG00000100578 Prot;Acc:Q9BVV6] 6.16 7.08 0.92 1.90 1.28E-03 8.29E-03 1.53E-03 6.69E-03 0.92 1 hsa-miR-222, Melanoregulin (Dilute suppressor protein homolog) MREG ENSG00000118242 [Source:UniProtKB/Swiss-Prot;Acc:Q8N565] 5.33 6.25 0.92 1.90 2.69E-05 3.53E-04 1.96E-10 4.65E-09 1.74 2 hsa-miR-19a,hsa-miR-7, High mobility group protein HMG-I/HMG-Y (HMG-I(Y))(High mobility group AT-hook protein 1)(High mobility group protein A1)(High mobility group protein R) [Source:UniProtKB/Swiss- HMGA1 ENSG00000137309 Prot;Acc:P17096] 6.96 7.89 0.92 1.90 4.27E-07 1.22E-05 1.94E-12 8.08E-11 1.23 1 hsa-miR-7, Rab GDP dissociation inhibitor alpha (Rab GDI alpha)(Guanosine diphosphate dissociation inhibitor 1)(GDI-1)(Oligophrenin-2)(Protein GDI1 ENSG00000203879 XAP-4) [Source:UniProtKB/Swiss-Prot;Acc:P31150] 8.03 8.96 0.93 1.90 1.10E-03 7.37E-03 4.42E-06 3.54E-05 1.21 2 hsa-miR-218,hsa-miR-24, Mps one binder kinase activator-like 2A (Mob1 homolog 2A)(MOB- MOBKL2A ENSG00000172081 LAK)(Protein Mob3A) [Source:UniProtKB/Swiss-Prot;Acc:Q96BX8] 8.05 8.98 0.93 1.91 2.28E-05 3.09E-04 3.23E-06 2.66E-05 0.93 1 hsa-miR-7, Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial Precursor (EC 2.5.1.17)(Cob(I)alamin adenosyltransferase)(Methylmalonic aciduria type B protein) MMAB ENSG00000139428 [Source:UniProtKB/Swiss-Prot;Acc:Q96EY8] 6.16 7.09 0.93 1.91 4.44E-04 3.50E-03 2.58E-09 4.49E-08 1.48 3 hsa-miR-130b,hsa-miR-19a,hsa-miR-24, Acidic repeat-containing protein [Source:UniProtKB/Swiss- ACRC ENSG00000147174 Prot;Acc:Q96QF7] 5.30 6.24 0.93 1.91 2.60E-04 2.25E-03 1.13E-05 8.25E-05 1.45 1 hsa-miR-24, Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein)(NCBP 80 kDa subunit)(CBP80) [Source:UniProtKB/Swiss- NCBP1 ENSG00000136937 Prot;Acc:Q09161] 6.24 7.18 0.93 1.91 1.49E-03 9.34E-03 6.11E-07 5.95E-06 1.61 3 hsa-miR-155,hsa-miR-218,hsa-miR-7, KLHL5 ENSG00000109790 Kelch-like protein 5 [Source:UniProtKB/Swiss-Prot;Acc:Q96PQ7] 5.99 6.92 0.93 1.91 8.23E-04 5.82E-03 2.86E-05 1.90E-04 0.97 2 hsa-miR-155,hsa-miR-7, FERM domain-containing protein 6 (Willin) [Source:UniProtKB/Swiss- FRMD6 ENSG00000139926 Prot;Acc:Q96NE9] 5.53 6.46 0.94 1.91 9.25E-06 1.48E-04 6.93E-07 6.64E-06 0.94 6 hsa-miR-19a,hsa-miR-200b,hsa-miR-218,hsa-miR-27a,hsa-miR-7,hsa-miR-93, Glutathione S-transferase C-terminal domain-containing protein GSTCD ENSG00000138780 [Source:UniProtKB/Swiss-Prot;Acc:Q8NEC7] 5.03 5.96 0.94 1.91 4.43E-06 8.24E-05 2.72E-10 6.21E-09 1.50 1 hsa-miR-155, DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10)(DNA-directed RNA polymerase III subunit K)(RNA polymerase III subunit C11)(RPC11)(HsC11p)(hRPC11)(DNA- directed RNA polymerases III 12.5 kDa polypeptide) POLR3K ENSG00000161980 [Source:UniProtKB/Swiss 7.15 8.09 0.94 1.91 3.32E-05 4.19E-04 5.78E-13 2.78E-11 1.80 2 hsa-miR-132,hsa-miR-7, Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1)(SCY1-like protein 3) SCYL3 ENSG00000000457 [Source:UniProtKB/Swiss-Prot;Acc:Q8IZE3] 5.63 6.57 0.94 1.92 4.16E-04 3.32E-03 2.54E-05 1.71E-04 1.07 2 hsa-let-7f,hsa-miR-132, Zinc finger MYM-type protein 3 (Zinc finger protein 261) ZMYM3 ENSG00000147130 [Source:UniProtKB/Swiss-Prot;Acc:Q14202] 6.03 6.97 0.94 1.92 4.59E-05 5.45E-04 2.53E-06 2.14E-05 0.94 2 hsa-miR-24,hsa-miR-7, Transmembrane emp24 domain-containing protein 9 Precursor TMED9 ENSG00000184840 (Glycoprotein 25L2) [Source:UniProtKB/Swiss-Prot;Acc:Q9BVK6] 6.94 7.88 0.94 1.92 1.53E-04 1.46E-03 1.49E-06 1.32E-05 1.17 1 hsa-miR-7, Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog) HPS4 ENSG00000100099 [Source:UniProtKB/Swiss-Prot;Acc:Q9NQG7] 6.35 7.29 0.94 1.92 6.83E-06 1.16E-04 4.35E-04 2.20E-03 0.94 1 hsa-miR-7, Aconitate hydratase, mitochondrial Precursor (Aconitase)(EC 4.2.1.3)(Citrate hydro-lyase) [Source:UniProtKB/Swiss- ACO2 ENSG00000100412 Prot;Acc:Q99798] 6.94 7.89 0.94 1.92 1.03E-04 1.06E-03 2.19E-10 5.16E-09 1.45 1 hsa-miR-7,

Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25)(Serine/threonine-protein kinase NIK)(NF-kappa beta- MAP3K14 ENSG00000006062 inducing kinase)(HsNIK) [Source:UniProtKB/Swiss-Prot;Acc:Q99558] 6.32 7.26 0.94 1.92 2.28E-06 4.80E-05 1.45E-07 1.66E-06 0.94 5 hsa-miR-155,hsa-miR-19a,hsa-miR-27a,hsa-miR-424,hsa-miR-7, Rho GTPase-activating protein 21 (Rho-type GTPase-activating protein 21)(Rho GTPase-activating protein 10) ARHGAP21 ENSG00000107863 [Source:UniProtKB/Swiss-Prot;Acc:Q5T5U3] 5.99 6.94 0.95 1.93 7.80E-05 8.42E-04 6.29E-05 3.87E-04 0.95 1 hsa-miR-19a, Protein kinase C alpha type (PKC-alpha)(PKC-A)(EC 2.7.11.13) PRKCA ENSG00000154229 [Source:UniProtKB/Swiss-Prot;Acc:P17252] 6.66 7.61 0.95 1.93 3.05E-04 2.58E-03 1.49E-05 1.06E-04 0.95 3 hsa-miR-200b,hsa-miR-24,hsa-miR-7, Transmembrane protein 14A [Source:UniProtKB/Swiss- TMEM14A ENSG00000096092 Prot;Acc:Q9Y6G1] 6.45 7.41 0.95 1.94 2.50E-04 2.19E-03 3.82E-07 3.90E-06 1.42 2 hsa-miR-200b,hsa-miR-7, S-adenosylmethionine synthetase isoform type-2 (AdoMet synthetase 2)(EC 2.5.1.6)(Methionine adenosyltransferase 2)(MAT 2)(Methionine adenosyltransferase II)(MAT-II) MAT2A ENSG00000168906 [Source:UniProtKB/Swiss-Prot;Acc:P31153] 8.05 9.00 0.95 1.94 5.82E-04 4.39E-03 3.30E-10 7.39E-09 1.95 1 hsa-miR-221, FAM98A ENSG00000119812 Protein FAM98A [Source:UniProtKB/Swiss-Prot;Acc:Q8NCA5] 5.56 6.52 0.95 1.94 4.38E-04 3.46E-03 4.17E-11 1.20E-09 2.18 1 hsa-miR-27a, L-2-hydroxyglutarate dehydrogenase, mitochondrial Precursor L2HGDH ENSG00000087299 (Duranin)(EC 1.1.99.2) [Source:UniProtKB/Swiss-Prot;Acc:Q9H9P8] 5.67 6.63 0.96 1.94 3.05E-07 9.34E-06 9.95E-13 4.44E-11 1.31 1 hsa-miR-155, FBXO48 ENSG00000204923 F-box only protein 48 [Source:UniProtKB/Swiss-Prot;Acc:Q5FWF7] 5.36 6.32 0.96 1.95 4.85E-05 5.70E-04 2.59E-05 1.74E-04 0.96 1 hsa-miR-19a, Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5)(Beta4Gal- T5)(b4Gal-T5)(EC 2.4.1.-)(UDP-galactose:beta-N- acetylglucosamine beta-1,4-galactosyltransferase 5)(UDP-Gal:beta- B4GALT5 ENSG00000158470 GlcNAc beta-1,4-galactosyltransferase 5)(Beta-1,4-GalT II) 6.01 6.97 0.96 1.95 5.40E-05 6.23E-04 3.11E-07 3.25E-06 1.16 3 hsa-miR-19a,hsa-miR-210,hsa-miR-7, Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100)(Isoprenylcysteine carboxylmethyltransferase)(Prenylcysteine carboxyl methyltransferase)(pcCMT)(Prenylated protein carboxyl methyltransferase)(PPMT) [Source:UniProtKB/Swiss- ICMT ENSG00000116237 Prot;Acc:O60725] 6.11 7.07 0.96 1.95 4.97E-07 1.38E-05 2.49E-13 1.37E-11 1.93 2 hsa-let-7f,hsa-miR-424, Lamin-B receptor (Integral nuclear envelope inner membrane LBR ENSG00000143815 protein)(LMN2R) [Source:UniProtKB/Swiss-Prot;Acc:Q14739] 7.21 8.17 0.96 1.95 8.81E-04 6.17E-03 4.86E-05 3.08E-04 1.26 1 hsa-miR-24, Pleckstrin homology domain-containing family B member 2 (Evectin-2) PLEKHB2 ENSG00000115762 [Source:UniProtKB/Swiss-Prot;Acc:Q96CS7] 7.06 8.03 0.96 1.95 2.20E-04 1.97E-03 7.30E-06 5.56E-05 0.99 1 hsa-miR-365, Digestive organ expansion factor homolog [Source:UniProtKB/Swiss- C1orf107 ENSG00000117597 Prot;Acc:Q68CQ4] 6.36 7.32 0.96 1.95 6.33E-05 7.11E-04 7.98E-07 7.56E-06 0.99 4 hsa-miR-155,hsa-miR-221,hsa-miR-24,hsa-miR-7, Transmembrane protein 70, mitochondrial Precursor TMEM70 ENSG00000175606 [Source:UniProtKB/Swiss-Prot;Acc:Q9BUB7] 6.42 7.38 0.96 1.95 3.02E-04 2.56E-03 1.16E-05 8.45E-05 1.48 1 hsa-miR-200b, GrpE protein homolog 2, mitochondrial Precursor (Mt-GrpE#2) GRPEL2 ENSG00000164284 [Source:UniProtKB/Swiss-Prot;Acc:Q8TAA5] 6.88 7.84 0.97 1.95 3.88E-06 7.38E-05 6.82E-08 8.47E-07 0.97 4 hsa-miR-21,hsa-miR-24,hsa-miR-29b,hsa-miR-365, Rho guanine nucleotide exchange factor 12 (Leukemia-associated ARHGEF12 ENSG00000196914 RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5] 5.11 6.08 0.97 1.95 7.75E-05 8.38E-04 2.91E-08 3.91E-07 1.34 5 hsa-miR-19a,hsa-miR-21,hsa-miR-218,hsa-miR-424,hsa-miR-7, Nucleoporin 50 kDa (Nuclear pore-associated protein 60 kDa-like) NUP50 ENSG00000093000 [Source:UniProtKB/Swiss-Prot;Acc:Q9UKX7] 7.03 8.00 0.97 1.95 1.29E-04 1.27E-03 1.36E-05 9.72E-05 1.09 4 hsa-miR-206,hsa-miR-210,hsa-miR-218,hsa-miR-7, Protein FAM20B Precursor [Source:UniProtKB/Swiss- FAM20B ENSG00000116199 Prot;Acc:O75063] 6.62 7.59 0.97 1.96 4.73E-04 3.69E-03 1.17E-06 1.07E-05 1.28 6 hsa-miR-155,hsa-miR-19b,hsa-miR-21,hsa-miR-218,hsa-miR-24,hsa-miR-7, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial Precursor (EC 2.3.1.168)(Dihydrolipoyllysine-residue (2- methylpropanoyl)transferase)(Dihydrolipoamide branched chain DBT ENSG00000137992 transacylase)(BCKAD E2 subunit) 6.04 7.01 0.97 1.96 1.24E-03 8.06E-03 1.96E-04 1.07E-03 0.97 5 hsa-miR-200b,hsa-miR-222,hsa-miR-363,hsa-miR-365,hsa-miR-7, Ubiquitin-conjugating enzyme E2 A (EC 6.3.2.19)(Ubiquitin-protein ligase A)(Ubiquitin carrier protein A)(HR6A)(hHR6A) UBE2A ENSG00000077721 [Source:UniProtKB/Swiss-Prot;Acc:P49459] 6.35 7.32 0.97 1.96 9.38E-04 6.47E-03 5.85E-05 3.63E-04 1.30 1 hsa-miR-19a, RNA-binding protein with serine-rich domain 1 (SR-related protein RNPS1 ENSG00000205937 LDC2) [Source:UniProtKB/Swiss-Prot;Acc:Q15287] 7.42 8.39 0.97 1.96 2.92E-04 2.49E-03 8.47E-07 7.96E-06 1.18 1 hsa-miR-222, Serine/threonine-protein kinase 24 (EC 2.7.11.1)(STE20-like kinase MST3)(MST-3)(Mammalian STE20-like protein kinase 3) STK24 ENSG00000102572 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y6E0] 7.79 8.76 0.97 1.96 9.30E-06 1.49E-04 1.12E-07 1.32E-06 0.97 4 hsa-miR-155,hsa-miR-21,hsa-miR-218,hsa-miR-221, UPF0684 protein C5orf30 [Source:UniProtKB/Swiss- C5orf30 ENSG00000181751 Prot;Acc:Q96GV9] 5.04 6.01 0.97 1.96 1.25E-04 1.23E-03 4.54E-10 9.78E-09 1.75 2 hsa-miR-18a,hsa-miR-19a, Presenilin-1 (PS-1)(EC 3.4.23.-)(Protein S182) [Contains Presenilin- 1 NTF subunit;Presenilin-1 CTF subunit;Presenilin-1 CTF12(PS1- PSEN1 ENSG00000080815 CTF12)] [Source:UniProtKB/Swiss-Prot;Acc:P49768] 6.91 7.88 0.97 1.96 5.54E-04 4.22E-03 2.36E-04 1.27E-03 0.97 1 hsa-miR-7, Torsin-1A Precursor (Torsin family 1 member A)(Dystonia 1 protein) TOR1A ENSG00000136827 [Source:UniProtKB/Swiss-Prot;Acc:O14656] 6.56 7.53 0.97 1.96 6.28E-05 7.06E-04 1.55E-08 2.23E-07 1.32 2 hsa-miR-18a,hsa-miR-210, Vacuolar protein sorting-associated protein 4A (VPS4- 1)(hVPS4)(Protein SKD2) [Source:UniProtKB/Swiss- VPS4A ENSG00000132612 Prot;Acc:Q9UN37] 6.77 7.74 0.97 1.96 2.03E-04 1.85E-03 8.69E-07 8.13E-06 1.11 1 hsa-miR-7, Kinetochore-associated protein NSL1 homolog hsa-miR-155,hsa-miR-18a,hsa-miR-21,hsa-miR-218,hsa-miR-221,hsa-miR-24,hsa- NSL1 ENSG00000117697 [Source:UniProtKB/Swiss-Prot;Acc:Q96IY1] 6.75 7.73 0.97 1.96 8.73E-04 6.11E-03 1.44E-05 1.03E-04 1.29 8 miR-27a,hsa-miR-7, Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A)(PP6-ARS-A)(Ankyrin repeat domain-containing protein ANKRD28 ENSG00000206560 28)(Phosphatase interactor targeting protein hnRNP K)(PITK) [S 6.22 7.19 0.97 1.96 6.35E-04 4.72E-03 3.65E-04 1.88E-03 0.97 5 hsa-miR-132,hsa-miR-18a,hsa-miR-200b,hsa-miR-365,hsa-miR-7, Tubulin--tyrosine ligase (TTL)(EC 6.3.2.25) TTL ENSG00000114999 [Source:UniProtKB/Swiss-Prot;Acc:Q8NG68] 5.93 6.90 0.97 1.96 2.00E-05 2.78E-04 2.19E-09 3.88E-08 1.43 1 hsa-miR-424, Zinc finger protein 280C (Suppressor of hairy wing homolog 3) ZNF280C ENSG00000056277 [Source:UniProtKB/Swiss-Prot;Acc:Q8ND82] 5.74 6.72 0.98 1.97 5.96E-05 6.76E-04 1.51E-05 1.07E-04 0.98 2 hsa-miR-218,hsa-miR-27a, Zinc transporter 7 (ZnT-7)(Znt-like transporter 2)(Solute carrier SLC30A7 ENSG00000162695 family 30 member 7) [Source:UniProtKB/Swiss-Prot;Acc:Q8NEW0] 7.05 8.03 0.98 1.97 1.02E-03 6.92E-03 6.58E-06 5.05E-05 1.28 3 hsa-miR-155,hsa-miR-19a,hsa-miR-365, Mitogen-activated protein kinase 6 (EC 2.7.11.24)(Extracellular signal- regulated kinase 3)(ERK-3)(MAP kinase isoform p97)(p97-MAPK) MAPK6 ENSG00000069956 [Source:UniProtKB/Swiss-Prot;Acc:Q16659] 5.79 6.77 0.98 1.97 1.43E-03 9.07E-03 5.25E-07 5.20E-06 1.75 1 hsa-miR-19b, TNFAIP3-interacting protein 1 (Nef-associated factor 1)(Naf1)(HIV-1 Nef-interacting protein)(Virion-associated nuclear shuttling protein)(VAN)(hVAN)(Nip40-1) [Source:UniProtKB/Swiss- TNIP1 ENSG00000145901 Prot;Acc:Q15025] 6.69 7.68 0.98 1.97 2.13E-07 7.02E-06 7.03E-09 1.09E-07 0.98 4 hsa-miR-19a,hsa-miR-210,hsa-miR-222,hsa-miR-424, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2)(EC 3.6.3.8)(Calcium pump 2)(Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform)(SR Ca(2+)-ATPase 2)(Endoplasmic reticulum class 1/2 ATP2A2 ENSG00000174437 Ca(2+) ATPase) [Sour 7.00 7.98 0.98 1.97 4.35E-05 5.20E-04 1.38E-10 3.41E-09 1.70 1 hsa-miR-363, Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1)(TdT-interacting DNTTIP1 ENSG00000101457 factor 1)(TdIF1) [Source:UniProtKB/Swiss-Prot;Acc:Q9H147] 6.38 7.36 0.98 1.98 1.10E-06 2.63E-05 3.11E-10 7.00E-09 1.35 1 hsa-miR-155, High mobility group protein B3 (High mobility group protein 4)(HMG- 4)(High mobility group protein 2a)(HMG-2a) HMGB3 ENSG00000029993 [Source:UniProtKB/Swiss-Prot;Acc:O15347] 6.35 7.34 0.98 1.98 4.16E-08 1.84E-06 1.21E-11 4.01E-10 0.98 3 hsa-miR-155,hsa-miR-200b,hsa-miR-27b, Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.1.2.15)(Ubiquitin thioesterase 48)(Ubiquitin-specific-processing protease 48)(Deubiquitinating enzyme 48) [Source:UniProtKB/Swiss- USP48 ENSG00000090686 Prot;Acc:Q86UV5] 6.32 7.31 0.98 1.98 1.10E-03 7.33E-03 8.43E-04 3.95E-03 0.98 2 hsa-miR-155,hsa-miR-365, ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1)(ARL2-like protein 1) [Source:UniProtKB/Swiss- ARL13B ENSG00000169379 Prot;Acc:Q3SXY8] 5.76 6.74 0.98 1.98 3.53E-05 4.38E-04 1.05E-10 2.71E-09 1.69 1 hsa-miR-130b, Protein BTG3 (BTG family member 3)(Protein Tob5)(Abundant in neuroepithelium area protein) [Source:UniProtKB/Swiss- BTG3 ENSG00000154640 Prot;Acc:Q14201] 7.75 8.73 0.99 1.98 2.95E-05 3.80E-04 2.33E-09 4.09E-08 1.34 1 hsa-miR-18a, Elongation factor 2 (EF-2) [Source:UniProtKB/Swiss- EEF2 ENSG00000167658 Prot;Acc:P13639] 9.96 10.95 0.99 1.98 2.08E-04 1.89E-03 2.12E-05 1.45E-04 0.99 1 hsa-miR-155, CUG-BP- and ETR-3-like factor 1 (CELF-1)(Bruno-like protein 2)(RNA-binding protein BRUNOL-2)(CUG triplet repeat RNA- binding protein 1)(CUG-BP1)(Deadenylation factor CUG-BP)(50 kDa nuclear polyadenylated RNA-binding protein)(Embryo deadenylation CUGBP1 ENSG00000149187 element-bi 6.85 7.84 0.99 1.99 4.77E-04 3.71E-03 1.65E-05 1.16E-04 1.12 1 hsa-miR-27a, Tudor domain-containing protein PHF20L1 [Source:UniProtKB/Swiss- PHF20L1 ENSG00000129292 Prot;Acc:A8MW92] 6.09 7.08 0.99 1.99 1.38E-03 8.79E-03 5.16E-05 3.25E-04 1.24 3 hsa-miR-132,hsa-miR-155,hsa-miR-365, Carboxypeptidase D Precursor (EC 3.4.17.22)(Metallocarboxypeptidase D)(gp180) CPD ENSG00000108582 [Source:UniProtKB/Swiss-Prot;Acc:O75976] 6.36 7.35 0.99 1.99 3.25E-04 2.72E-03 1.00E-04 5.86E-04 0.99 5 hsa-miR-155,hsa-miR-19a,hsa-miR-200b,hsa-miR-27a,hsa-miR-7, 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (EC 2.3.1.51)(1-acylglycerol-3-phosphate O-acyltransferase 3)(1-AGP acyltransferase 3)(1-AGPAT 3)(Lysophosphatidic acid acyltransferase gamma)(LPAAT-gamma) [Source:UniProtKB/Swiss- AGPAT3 ENSG00000160216 Prot;Acc:Q9NRZ7] 6.54 7.54 0.99 1.99 2.68E-06 5.50E-05 9.04E-09 1.37E-07 1.18 5 hsa-miR-132,hsa-miR-218,hsa-miR-24,hsa-miR-27b,hsa-miR-7, Regulatory factor X-associated protein (RFX-associated protein)(RFX DNA-binding complex 36 kDa subunit) RFXAP ENSG00000133111 [Source:UniProtKB/Swiss-Prot;Acc:O00287] 6.48 7.47 0.99 1.99 9.64E-05 1.00E-03 2.33E-07 2.53E-06 1.04 1 hsa-miR-132, Caspase-6 Precursor (CASP-6)(EC 3.4.22.59)(Apoptotic protease Mch-2) [Contains Caspase-6 subunit p18;Caspase-6 subunit p11] CASP6 ENSG00000138794 [Source:UniProtKB/Swiss-Prot;Acc:P55212] 6.24 7.23 0.99 1.99 7.13E-04 5.19E-03 1.07E-04 6.21E-04 0.99 1 hsa-miR-155, Small nuclear ribonucleoprotein Sm D3 (Sm-D3)(snRNP core protein SNRPD3 ENSG00000100028 D3) [Source:UniProtKB/Swiss-Prot;Acc:P62318] 8.24 9.24 0.99 1.99 2.57E-05 3.39E-04 1.37E-10 3.40E-09 1.44 1 hsa-miR-21, RNA-binding protein 4B (RNA-binding motif protein 4B)(RNA- binding protein 30)(RNA-binding motif protein 30) RBM4B ENSG00000173914 [Source:UniProtKB/Swiss-Prot;Acc:Q9BQ04] 6.99 7.98 0.99 1.99 6.87E-05 7.59E-04 2.29E-07 2.48E-06 1.02 1 hsa-miR-155, FAM54B ENSG00000117640 Protein FAM54B [Source:UniProtKB/Swiss-Prot;Acc:Q9H019] 6.29 7.29 0.99 1.99 4.50E-04 3.54E-03 1.11E-04 6.44E-04 0.99 2 hsa-miR-424,hsa-miR-7, Frizzled-3 Precursor (Fz-3)(hFz3) [Source:UniProtKB/Swiss- FZD3 ENSG00000104290 Prot;Acc:Q9NPG1] 5.68 6.68 0.99 1.99 2.81E-05 3.65E-04 6.96E-06 5.32E-05 1.10 1 hsa-miR-365, 39S ribosomal protein L11, mitochondrial Precursor (L11mt)(MRP- MRPL11 ENSG00000174547 L11) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y3B7] 7.26 8.25 0.99 1.99 6.90E-05 7.62E-04 3.46E-09 5.81E-08 1.47 1 hsa-miR-7, Neuropilin and tolloid-like protein 2 Precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A NETO2 ENSG00000171208 domains protein 2) [Source:UniProtKB/Swiss-Prot;Acc:Q8NC67] 4.85 5.84 1.00 1.99 1.78E-05 2.52E-04 1.48E-11 4.75E-10 2.07 1 hsa-miR-155, DAZ-associated protein 1 (Deleted in azoospermia-associated protein DAZAP1 ENSG00000071626 1) [Source:UniProtKB/Swiss-Prot;Acc:Q96EP5] 7.05 8.05 1.00 1.99 1.93E-06 4.20E-05 2.60E-11 7.85E-10 1.37 2 hsa-miR-218,hsa-miR-24, Zinc finger protein Gfi-1 (Growth factor independent protein 1)(Zinc GFI1 ENSG00000162676 finger protein 163) [Source:UniProtKB/Swiss-Prot;Acc:Q99684] 6.55 7.55 1.00 1.99 8.69E-08 3.35E-06 1.86E-09 3.36E-08 1.00 1 hsa-miR-155, Hypoxia up-regulated protein 1 Precursor (150 kDa oxygen-regulated HYOU1 ENSG00000149428 protein)(Orp150) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y4L1] 6.66 7.66 1.00 2.00 7.18E-05 7.88E-04 1.02E-09 1.96E-08 1.50 3 hsa-miR-200b,hsa-miR-222,hsa-miR-27a, Rap1 GTPase-GDP dissociation stimulator 1 (SMG GDS protein)(SMG P21 stimulatory GDP/GTP exchange protein)(Exchange factor smgGDS) [Source:UniProtKB/Swiss- RAP1GDS1 ENSG00000138698 Prot;Acc:P52306] 6.40 7.40 1.00 2.00 1.53E-03 9.55E-03 5.44E-05 3.40E-04 1.27 3 hsa-miR-155,hsa-miR-218,hsa-miR-7, Uridine 5'-monophosphate synthase (UMP synthase) [Includes Orotate phosphoribosyltransferase(OPRTase)(EC 2.4.2.10);Orotidine 5'-phosphate decarboxylase(EC 4.1.1.23)(OMPdecase)] UMPS ENSG00000114491 [Source:UniProtKB/Swiss-Prot;Acc:P11172] 5.93 6.93 1.00 2.00 9.06E-05 9.49E-04 4.80E-10 1.03E-08 1.86 1 hsa-miR-7, CD59 glycoprotein Precursor (Membrane attack complex inhibition factor)(MACIF)(MAC-inhibitory protein)(MAC- IP)(Protectin)(MEM43 antigen)(Membrane inhibitor of reactive lysis)(MIRL)(20 kDa homologous restriction factor)(HRF- CD59 ENSG00000085063 20)(HRF20)(1F5 antigen)(CD59 ant 6.90 7.90 1.00 2.00 1.12E-04 1.13E-03 8.05E-05 4.82E-04 1.00 2 hsa-miR-155,hsa-miR-7, Fanconi anemia group F protein (Protein FACF) FANCF ENSG00000183161 [Source:UniProtKB/Swiss-Prot;Acc:Q9NPI8] 6.27 7.27 1.00 2.00 1.01E-04 1.04E-03 2.32E-06 1.98E-05 1.24 2 hsa-miR-155,hsa-miR-210, RAS guanyl-releasing protein 1 (Ras guanyl-releasing protein)(Calcium and DAG-regulated guanine nucleotide exchange factor II)(CalDAG-GEFII) [Source:UniProtKB/Swiss- RASGRP1 ENSG00000172575 Prot;Acc:O95267] 8.33 9.33 1.00 2.00 1.29E-03 8.34E-03 1.21E-03 5.43E-03 1.00 2 hsa-let-7f,hsa-miR-222, La-related protein 1 (La ribonucleoprotein domain family member 1) LARP1 ENSG00000155506 [Source:UniProtKB/Swiss-Prot;Acc:Q6PKG0] 7.65 8.65 1.00 2.00 4.84E-05 5.69E-04 8.27E-09 1.27E-07 1.34 1 hsa-miR-24, Guanine nucleotide-binding protein-like 3-like protein GNL3L ENSG00000130119 [Source:UniProtKB/Swiss-Prot;Acc:Q9NVN8] 6.39 7.39 1.00 2.00 3.98E-04 3.21E-03 2.68E-08 3.63E-07 1.59 2 hsa-miR-155,hsa-miR-7, GPI ethanolamine phosphate transferase 1 (EC 2.-.-.- )(Phosphatidylinositol-glycan biosynthesis class N protein)(PIG- PIGN ENSG00000197563 N)(MCD4 homolog) [Source:UniProtKB/Swiss-Prot;Acc:O95427] 5.83 6.84 1.01 2.01 5.22E-04 4.01E-03 2.23E-05 1.52E-04 1.26 2 hsa-miR-155,hsa-miR-21, Double-stranded RNA-binding protein Staufen homolog 1 STAU1 ENSG00000124214 [Source:UniProtKB/Swiss-Prot;Acc:O95793] 7.28 8.28 1.01 2.01 7.84E-05 8.45E-04 2.37E-05 1.61E-04 1.01 1 hsa-miR-7, Enhancer of mRNA-decapping protein 3 (LSM16 homolog)(YjeF domain-containing protein 1)(YjeF N-terminal domain-containing protein 2)(YjeF_N2)(hYjeF_N2) [Source:UniProtKB/Swiss- EDC3 ENSG00000179151 Prot;Acc:Q96F86] 6.86 7.87 1.01 2.01 5.17E-06 9.28E-05 1.12E-08 1.66E-07 1.04 1 hsa-miR-24, Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1)(eRF1)(TB3-1)(Protein Cl1) [Source:UniProtKB/Swiss- ETF1 ENSG00000120705 Prot;Acc:P62495] 6.26 7.27 1.01 2.01 1.56E-03 9.68E-03 5.33E-07 5.27E-06 1.73 1 hsa-miR-200b, Cell division protein kinase 8 (EC 2.7.11.22)(EC 2.7.11.23)(Cyclin- dependent kinase 8)(Mediator of RNA polymerase II transcription subunit CDK8)(Mediator complex subunit CDK8)(Protein kinase K35) CDK8 ENSG00000132964 [Source:UniProtKB/Swiss-Prot;Acc:P49336] 5.86 6.86 1.01 2.01 9.29E-04 6.42E-03 1.39E-04 7.90E-04 1.10 2 hsa-miR-222,hsa-miR-27a, E3 ubiquitin-protein ligase RNF167 Precursor (EC 6.3.2.-)(RING finger protein 167)(RING105) [Source:UniProtKB/Swiss- RNF167 ENSG00000108523 Prot;Acc:Q9H6Y7] 7.58 8.58 1.01 2.01 5.33E-04 4.08E-03 2.03E-05 1.40E-04 1.06 2 hsa-miR-19a,hsa-miR-7, UPF0489 protein C5orf22 [Source:UniProtKB/Swiss- C5orf22 ENSG00000082213 Prot;Acc:Q49AR2] 5.92 6.93 1.01 2.01 1.02E-03 6.91E-03 1.82E-06 1.59E-05 1.44 1 hsa-miR-7, GrpE protein homolog 1, mitochondrial Precursor (Mt- GRPEL1 ENSG00000109519 GrpE#1)(HMGE) [Source:UniProtKB/Swiss-Prot;Acc:Q9HAV7] 6.45 7.46 1.01 2.01 5.98E-04 4.48E-03 1.37E-07 1.58E-06 1.53 1 hsa-miR-155, Transcription elongation factor SPT4 (hSPT4)(DRB sensitivity- inducing factor small subunit)(DSIF small subunit)(DSIF p14) SUPT4H1 ENSG00000213246 [Source:UniProtKB/Swiss-Prot;Acc:P63272] 7.47 8.48 1.01 2.01 2.56E-04 2.22E-03 1.77E-07 1.98E-06 1.47 1 hsa-miR-7, Integrin alpha-V Precursor (Vitronectin receptor subunit alpha)(CD51 antigen) [Contains Integrin alpha-V heavy chain;Integrin alpha-V light ITGAV ENSG00000138448 chain] [Source:UniProtKB/Swiss-Prot;Acc:P06756] 5.84 6.85 1.01 2.02 3.46E-05 4.32E-04 1.21E-06 1.10E-05 1.01 2 hsa-miR-135b,hsa-miR-155, StAR-related lipid transfer protein 7, mitochondrial Precursor (START domain-containing protein 7)(StARD7)(Gestational STARD7 ENSG00000084090 trophoblastic tumor protein 1) [Source:UniProtKB/Swiss- 7.91 8.92 1.01 2.02 1.95E-05 2.72E-04 1.28E-10 3.22E-09 1.46 1 hsa-miR-18a, Neutral alpha-glucosidase AB Precursor (EC 3.2.1.84)(Glucosidase II subunit alpha)(Alpha-glucosidase 2) [Source:UniProtKB/Swiss- GANAB ENSG00000089597 Prot;Acc:Q14697] 7.23 8.24 1.01 2.02 4.83E-04 3.76E-03 2.34E-05 1.59E-04 1.01 1 hsa-miR-155, Solute carrier family 25 member 46 [Source:UniProtKB/Swiss- SLC25A46 ENSG00000164209 Prot;Acc:Q96AG3] 7.02 8.04 1.02 2.02 1.71E-04 1.61E-03 3.69E-07 3.79E-06 1.31 2 hsa-miR-18a,hsa-miR-222, NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger NFXL1 ENSG00000170448 protein)(hOZFP) [Source:UniProtKB/Swiss-Prot;Acc:Q6ZNB6] 6.07 7.09 1.02 2.02 2.90E-04 2.47E-03 6.75E-05 4.12E-04 1.02 2 hsa-miR-132,hsa-miR-24, Zinc finger protein RFP (Ret finger protein)(Tripartite motif- containing protein 27)(RING finger protein 76) TRIM27 ENSG00000204713 [Source:UniProtKB/Swiss-Prot;Acc:P14373] 6.53 7.55 1.02 2.02 2.20E-04 1.97E-03 1.37E-07 1.58E-06 1.40 1 hsa-miR-155,

Cysteine-rich motor neuron 1 protein Precursor (CRIM-1)(Cysteine- rich repeat-containing protein S52) [Contains Processed cysteine-rich CRIM1 ENSG00000150938 motor neuron 1 protein] [Source:UniProtKB/Swiss-Prot;Acc:Q9NZV1] 5.94 6.95 1.02 2.02 3.23E-07 9.75E-06 4.31E-08 5.57E-07 1.02 4 hsa-miR-132,hsa-miR-18a,hsa-miR-424,hsa-miR-7, p53 apoptosis effector related to PMP-22 (Keratinocyte-associated protein 1)(KCP-1)(P53-induced protein PIGPC1)(Transmembrane PERP ENSG00000112378 protein THW) [Source:UniProtKB/Swiss-Prot;Acc:Q96FX8] 6.16 7.18 1.02 2.02 4.65E-06 8.53E-05 1.06E-05 7.79E-05 1.02 1 hsa-miR-155, 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein)(PAP)(PDGFA-associated protein 1)(PAP1) PDAP1 ENSG00000106244 [Source:UniProtKB/Swiss-Prot;Acc:Q13442] 5.61 6.63 1.02 2.03 3.20E-05 4.06E-04 1.66E-08 2.36E-07 1.48 1 hsa-miR-21, Voltage-gated potassium channel subunit beta-2 (K(+) channel subunit beta-2)(Kv-beta-2)(HKvbeta2) [Source:UniProtKB/Swiss- KCNAB2 ENSG00000069424 Prot;Acc:Q13303] 7.58 8.59 1.02 2.03 5.86E-04 4.41E-03 3.98E-06 3.22E-05 1.23 1 hsa-miR-7, Putative alpha-1,2-glucosyltransferase ALG10-B (Alpha-2- glucosyltransferase ALG10-B)(EC 2.4.1.-)(Asparagine-linked glycosylation protein 10 homolog B)(Potassium channel regulator 1) ALG10B ENSG00000175548 [Source:UniProtKB/Swiss-Prot;Acc:Q5I7T1] 6.33 7.35 1.02 2.03 5.74E-05 6.53E-04 2.45E-06 2.08E-05 1.19 3 hsa-miR-132,hsa-miR-200b,hsa-miR-7, BTB/POZ domain-containing protein KCTD21 KCTD21 ENSG00000188997 [Source:UniProtKB/Swiss-Prot;Acc:Q4G0X4] 5.38 6.40 1.02 2.03 3.48E-08 1.60E-06 3.83E-12 1.46E-10 1.14 3 hsa-miR-24,hsa-miR-27a,hsa-miR-98, Tripartite motif-containing protein 59 (Tumor suppressor TSBF- 1)(RING finger protein 104) [Source:UniProtKB/Swiss- TRIM59 ENSG00000213186 Prot;Acc:Q8IWR1] 5.38 6.40 1.02 2.03 2.25E-06 4.76E-05 6.47E-07 6.26E-06 1.02 1 hsa-miR-21, Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2)(TGF(beta)- induced transcription factor 2)(TGFB-induced factor 2) TGIF2 ENSG00000118707 [Source:UniProtKB/Swiss-Prot;Acc:Q9GZN2] 6.46 7.48 1.02 2.03 4.63E-06 8.50E-05 2.92E-06 2.43E-05 1.02 3 hsa-miR-218,hsa-miR-24,hsa-miR-7, MMS19 nucleotide excision repair protein homolog (hMMS19)(MMS19-like protein)(MET18 homolog) MMS19 ENSG00000155229 [Source:UniProtKB/Swiss-Prot;Acc:Q96T76] 7.05 8.08 1.02 2.03 1.58E-05 2.31E-04 1.44E-07 1.65E-06 1.02 2 hsa-miR-132,hsa-miR-424, T-complex protein 11-like protein 1 [Source:UniProtKB/Swiss- TCP11L1 ENSG00000176148 Prot;Acc:Q9NUJ3] 6.03 7.05 1.02 2.03 9.77E-08 3.71E-06 1.63E-10 3.94E-09 1.11 1 hsa-miR-200b, Interleukin-28 receptor alpha chain Precursor (IL-28R-alpha)(IL- 28RA)(Cytokine receptor class-II member 12)(Cytokine receptor family 2 member 12)(CRF2-12)(Interferon lambda receptor 1)(IFN-lambda IL28RA ENSG00000185436 R1)(Likely interleukin or cytokine receptor 2) [Source:UniP 5.89 6.91 1.02 2.03 3.13E-05 4.00E-04 5.07E-07 5.04E-06 1.02 1 hsa-miR-221, Splicing factor, arginine/serine-rich 4 (Pre-mRNA-splicing factor SFRS4 ENSG00000116350 SRP75)(SRP001LB) [Source:UniProtKB/Swiss-Prot;Acc:Q08170] 7.64 8.67 1.02 2.03 2.46E-05 3.28E-04 3.16E-08 4.22E-07 1.02 1 hsa-miR-218, Insulin-degrading enzyme (EC 3.4.24.56)(Insulin protease)(Insulinase)(Insulysin) [Source:UniProtKB/Swiss- IDE ENSG00000119912 Prot;Acc:P14735] 5.51 6.53 1.02 2.03 9.22E-04 6.39E-03 4.04E-09 6.65E-08 2.08 1 hsa-miR-7, Cathepsin B Precursor (EC 3.4.22.1)(Cathepsin B1)(APP secretase)(APPS) [Contains Cathepsin B light chain;Cathepsin B CTSB ENSG00000164733 heavy chain] [Source:UniProtKB/Swiss-Prot;Acc:P07858] 7.46 8.49 1.02 2.03 1.07E-05 1.67E-04 1.72E-07 1.93E-06 1.02 1 hsa-miR-7, Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-)(DEAH DHX33 ENSG00000005100 box protein 33) [Source:UniProtKB/Swiss-Prot;Acc:Q9H6R0] 5.65 6.68 1.03 2.04 1.13E-07 4.18E-06 4.56E-14 3.10E-12 1.47 2 hsa-miR-24,hsa-miR-7, CRKL ENSG00000099942 Crk-like protein [Source:UniProtKB/Swiss-Prot;Acc:P46109] 7.29 8.32 1.03 2.04 7.95E-06 1.31E-04 1.02E-06 9.43E-06 1.03 4 hsa-miR-218,hsa-miR-221,hsa-miR-365,hsa-miR-7, Tripartite motif-containing protein 37 (Mulibrey nanism protein) TRIM37 ENSG00000108395 [Source:UniProtKB/Swiss-Prot;Acc:O94972] 5.77 6.81 1.03 2.04 1.31E-03 8.46E-03 1.18E-06 1.08E-05 1.62 1 hsa-miR-19a, PHF14 ENSG00000106443 PHD finger protein 14 [Source:UniProtKB/Swiss-Prot;Acc:O94880] 6.00 7.03 1.03 2.05 1.18E-03 7.77E-03 4.41E-06 3.54E-05 1.26 1 hsa-miR-19a, Ubiquitin carboxyl-terminal hydrolase 45 (EC 3.1.2.15)(Ubiquitin thioesterase 45)(Ubiquitin-specific-processing protease 45)(Deubiquitinating enzyme 45) [Source:UniProtKB/Swiss- USP45 ENSG00000123552 Prot;Acc:Q70EL2] 5.21 6.24 1.03 2.05 5.04E-05 5.88E-04 4.14E-07 4.19E-06 1.45 5 hsa-miR-155,hsa-miR-218,hsa-miR-27a,hsa-miR-363,hsa-miR-7, hsa-miR-132,hsa-miR-155,hsa-miR-19a,hsa-miR-24,hsa-miR-27a,hsa-miR-365,hsa- NCALD ENSG00000104490 Neurocalcin-delta [Source:UniProtKB/Swiss-Prot;Acc:P61601] 5.85 6.89 1.04 2.05 3.12E-04 2.62E-03 3.00E-05 1.98E-04 1.04 7 miR-7, Protein C20orf11 (Two hybrid-associated protein 1 with C20orf11 ENSG00000101193 RanBPM)(Twa1) [Source:UniProtKB/Swiss-Prot;Acc:Q9NWU2] 6.60 7.63 1.04 2.05 5.33E-04 4.08E-03 9.86E-06 7.30E-05 1.23 1 hsa-miR-7, Calcium-binding mitochondrial carrier protein Aralar1 (Mitochondrial aspartate glutamate carrier 1)(Solute carrier family 25 member 12) SLC25A12 ENSG00000115840 [Source:UniProtKB/Swiss-Prot;Acc:O75746] 5.78 6.82 1.04 2.05 9.02E-04 6.27E-03 8.63E-07 8.09E-06 1.57 2 hsa-miR-19a,hsa-miR-424, GTP-binding protein GUF1 homolog [Source:UniProtKB/Swiss- GUF1 ENSG00000151806 Prot;Acc:Q8N442] 5.54 6.58 1.04 2.06 3.04E-05 3.89E-04 3.26E-10 7.30E-09 1.57 1 hsa-miR-18a, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform)(PP2A, subunit A, PPP2R1B ENSG00000137713 R1-beta isoform) [Source:UniProtKB/Swiss-Prot;Acc:P30154] 6.57 7.61 1.04 2.06 9.56E-04 6.56E-03 3.56E-08 4.69E-07 1.71 1 hsa-miR-7, Uncharacterized protein C7orf44 [Source:UniProtKB/Swiss- C7orf44 ENSG00000106603 Prot;Acc:Q9GZY4] 6.65 7.69 1.05 2.06 5.14E-05 5.98E-04 2.48E-08 3.39E-07 1.27 1 hsa-miR-218, Mitochondrial fission regulator 1 (Chondrocyte protein with a poly- MTFR1 ENSG00000066855 proline region) [Source:UniProtKB/Swiss-Prot;Acc:Q15390] 5.75 6.80 1.05 2.07 6.44E-07 1.70E-05 1.08E-10 2.77E-09 1.47 1 hsa-miR-132, SNX1 ENSG00000028528 Sorting nexin-1 [Source:UniProtKB/Swiss-Prot;Acc:Q13596] 6.08 7.13 1.05 2.07 1.10E-03 7.34E-03 8.01E-05 4.80E-04 1.18 2 hsa-miR-155,hsa-miR-24, Translocation protein SEC63 homolog [Source:UniProtKB/Swiss- SEC63 ENSG00000025796 Prot;Acc:Q9UGP8] 7.13 8.18 1.05 2.07 1.46E-03 9.21E-03 1.94E-04 1.06E-03 1.09 1 hsa-miR-19a, Beta-1,4-galactosyltransferase 3 (Beta-1,4-GalTase 3)(Beta4Gal- T3)(b4Gal-T3)(EC 2.4.1.-)(UDP-galactose:beta-N- acetylglucosamine beta-1,4-galactosyltransferase 3)(UDP-Gal:beta- B4GALT3 ENSG00000158850 GlcNAc beta-1,4-galactosyltransferase 3) [Includes N- 6.88 7.93 1.05 2.07 2.66E-05 3.49E-04 8.56E-07 8.03E-06 1.05 2 hsa-miR-27a,hsa-miR-7, Neuronal calcium sensor 1 (NCS-1)(Frequenin homolog)(Frequenin- like protein)(Frequenin-like ubiquitous protein) FREQ ENSG00000107130 [Source:UniProtKB/Swiss-Prot;Acc:P62166] 5.01 6.06 1.05 2.07 3.13E-07 9.49E-06 6.42E-17 1.00E-14 2.05 1 hsa-miR-27a, Pre-mRNA-processing factor 19 (PRP19/PSO4 homolog)(hPso4)(Nuclear matrix protein 200)(Senescence evasion PRPF19 ENSG00000110107 factor) [Source:UniProtKB/Swiss-Prot;Acc:Q9UMS4] 6.91 7.96 1.05 2.07 4.49E-06 8.31E-05 1.38E-10 3.42E-09 1.44 1 hsa-miR-27a, Serine/threonine-protein kinase TBK1 (EC 2.7.11.1)(TANK-binding kinase 1)(T2K)(NF-kappa-B-activating kinase) TBK1 ENSG00000183735 [Source:UniProtKB/Swiss-Prot;Acc:Q9UHD2] 6.11 7.16 1.05 2.07 1.22E-04 1.21E-03 1.56E-06 1.38E-05 1.50 4 hsa-miR-155,hsa-miR-19a,hsa-miR-200b,hsa-miR-365, Transcription regulator protein BACH1 (BTB and CNC homolog BACH1 ENSG00000156273 1)(HA2303) [Source:UniProtKB/Swiss-Prot;Acc:O14867] 6.31 7.36 1.05 2.07 2.03E-04 1.85E-03 1.35E-04 7.70E-04 1.05 3 hsa-miR-135b,hsa-miR-155,hsa-miR-21, Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha- SEC61A1 ENSG00000058262 1) [Source:UniProtKB/Swiss-Prot;Acc:P61619] 7.88 8.94 1.05 2.07 1.11E-04 1.12E-03 7.93E-08 9.66E-07 1.37 4 hsa-miR-18a,hsa-miR-19a,hsa-miR-218,hsa-miR-7, 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNPase)(CNP)(EC CNP ENSG00000173786 3.1.4.37) [Source:UniProtKB/Swiss-Prot;Acc:P09543] 5.79 6.85 1.05 2.07 2.02E-06 4.36E-05 1.35E-10 3.36E-09 1.61 2 hsa-miR-210,hsa-miR-7, Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) EI24 ENSG00000149547 [Source:UniProtKB/Swiss-Prot;Acc:O14681] 6.28 7.33 1.05 2.07 9.55E-05 9.94E-04 1.22E-08 1.79E-07 1.54 1 hsa-miR-27a, Glycogen debranching enzyme (Glycogen debrancher) [Includes 4- alpha-glucanotransferase(EC 2.4.1.25)(Oligo-1,4-1,4- glucantransferase);Amylo-alpha-1,6-glucosidase(Amylo-1,6- glucosidase)(EC 3.2.1.33)(Dextrin 6-alpha-D-glucosidase)] AGL ENSG00000162688 [Source:UniProtKB/Swiss-Pr 5.82 6.88 1.05 2.08 3.53E-04 2.90E-03 1.28E-05 9.22E-05 1.18 1 hsa-miR-155, Nck-associated protein 1 (NAP 1)(p125Nap1)(Membrane-associated NCKAP1 ENSG00000061676 protein HEM-2) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2A7] 4.86 5.92 1.05 2.08 2.41E-04 2.12E-03 8.07E-07 7.62E-06 1.44 1 hsa-miR-365, Uncharacterized protein C2orf42 [Source:UniProtKB/Swiss- C2orf42 ENSG00000115998 Prot;Acc:Q9NWW7] 6.07 7.13 1.05 2.08 1.20E-04 1.19E-03 9.22E-06 6.86E-05 1.05 1 hsa-miR-19a, Cyclin-dependent kinase 5 activator 1 Precursor (CDK5 activator 1)(Cyclin-dependent kinase 5 regulatory subunit 1)(Tau protein kinase II 23 kDa subunit)(p23)(TPKII regulatory subunit) [Contains Cyclin- CDK5R1 ENSG00000176749 dependent kinase 5 activator 1, p35(p35);Cyclin-depend 5.87 6.93 1.05 2.08 1.76E-04 1.64E-03 4.22E-05 2.71E-04 1.05 5 hsa-miR-18a,hsa-miR-200b,hsa-miR-27b,hsa-miR-363,hsa-miR-7, Uncharacterized protein C6orf182 [Source:UniProtKB/Swiss- C6orf182 ENSG00000183137 Prot;Acc:Q8IYX8] 6.08 7.14 1.05 2.08 2.82E-06 5.73E-05 1.52E-08 2.18E-07 1.13 2 hsa-miR-155,hsa-miR-21, Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1)(Acetate-- CoA ligase)(Acyl-activating enzyme)(Acetyl-CoA synthetase)(AceCS)(ACS)(Acyl-CoA synthetase short-chain family ACSS2 ENSG00000131069 member 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9NR19] 5.59 6.64 1.06 2.08 2.94E-07 9.05E-06 4.32E-11 1.24E-09 1.49 1 hsa-miR-7, Uncharacterized protein C1orf83 [Source:UniProtKB/Swiss- C1orf83 ENSG00000116205 Prot;Acc:Q96MN5] 5.58 6.64 1.06 2.08 6.10E-05 6.89E-04 6.68E-07 6.44E-06 1.26 2 hsa-miR-210,hsa-miR-27a, Mitogen-activated protein kinase 13 (EC 2.7.11.24)(Stress-activated protein kinase 4)(Mitogen-activated protein kinase p38 delta)(MAP MAPK13 ENSG00000156711 kinase p38 delta) [Source:UniProtKB/Swiss-Prot;Acc:O15264] 6.59 7.65 1.06 2.08 1.84E-05 2.59E-04 1.77E-07 1.98E-06 1.15 1 hsa-miR-24, Hermansky-Pudlak syndrome 5 protein (Alpha-integrin-binding protein 63)(Ruby-eye protein 2 homolog)(Ru2) [Source:UniProtKB/Swiss- HPS5 ENSG00000110756 Prot;Acc:Q9UPZ3] 5.48 6.54 1.06 2.08 1.19E-04 1.19E-03 1.30E-06 1.17E-05 1.31 2 hsa-miR-200b,hsa-miR-21, Actin-related protein 3 (Actin-like protein 3) [Source:UniProtKB/Swiss- ACTR3 ENSG00000115091 Prot;Acc:P61158] 8.94 10.00 1.06 2.08 1.50E-04 1.44E-03 1.22E-06 1.11E-05 1.14 1 hsa-miR-200b, Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.43)(Histone H3- K4 methyltransferase SETD7)(H3-K4-HMTase SETD7)(SET domain- containing protein 7)(SET7/9)(Lysine N-methyltransferase 7) hsa-miR-155,hsa-miR-200b,hsa-miR-218,hsa-miR-24,hsa-miR-27a,hsa-miR-363,hsa- SETD7 ENSG00000145391 [Source:UniProtKB/Swiss-Prot;Acc:Q8WTS6] 5.58 6.64 1.06 2.09 2.99E-06 6.03E-05 3.04E-07 3.18E-06 1.06 8 miR-365,hsa-miR-7, 28S ribosomal protein S2, mitochondrial (S2mt)(MRP-S2) MRPS2 ENSG00000122140 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y399] 6.63 7.69 1.06 2.09 1.47E-05 2.16E-04 3.42E-06 2.80E-05 1.23 1 hsa-miR-424, ADP-ribosylation factor-like protein 5A [Source:UniProtKB/Swiss- ARL5A ENSG00000162980 Prot;Acc:Q9Y689] 6.83 7.89 1.06 2.09 4.30E-04 3.42E-03 1.02E-07 1.22E-06 1.63 2 hsa-miR-155,hsa-miR-200b, Histone deacetylase 1 (HD1)(EC 3.5.1.98) [Source:UniProtKB/Swiss- HDAC1 ENSG00000116478 Prot;Acc:Q13547] 7.60 8.67 1.06 2.09 7.47E-04 5.39E-03 2.54E-06 2.15E-05 1.39 1 hsa-miR-7, MAX-interacting protein 1 (Protein MXI1) [Source:UniProtKB/Swiss- MXI1 ENSG00000119950 Prot;Acc:P50539] 6.75 7.82 1.06 2.09 1.48E-03 9.30E-03 4.78E-04 2.38E-03 1.25 1 hsa-miR-24, Polypyrimidine tract-binding protein 1 (PTB)(Heterogeneous nuclear ribonucleoprotein I)(hnRNP I)(57 kDa RNA-binding protein PPTB-1) PTBP1 ENSG00000011304 [Source:UniProtKB/Swiss-Prot;Acc:P26599] 8.30 9.36 1.06 2.09 7.38E-06 1.23E-04 1.43E-10 3.53E-09 1.42 3 hsa-miR-200b,hsa-miR-206,hsa-miR-210, Antizyme inhibitor 1 (AZI)(Ornithine decarboxylase antizyme inhibitor) AZIN1 ENSG00000155096 [Source:UniProtKB/Swiss-Prot;Acc:O14977] 7.94 9.00 1.06 2.09 7.24E-04 5.26E-03 6.40E-05 3.93E-04 1.15 5 hsa-miR-132,hsa-miR-155,hsa-miR-19a,hsa-miR-218,hsa-miR-365, LYR motif-containing protein 1 [Source:UniProtKB/Swiss- LYRM1 ENSG00000102897 Prot;Acc:O43325] 5.95 7.02 1.06 2.09 1.16E-04 1.16E-03 4.25E-07 4.30E-06 1.24 1 hsa-miR-24, Derlin-1 (Der1-like protein 1)(Degradation in endoplasmic reticulum DERL1 ENSG00000136986 protein 1)(DERtrin-1) [Source:UniProtKB/Swiss-Prot;Acc:Q9BUN8] 7.06 8.12 1.06 2.09 1.43E-03 9.04E-03 6.47E-04 3.12E-03 1.06 1 hsa-miR-218, Vesicle-associated membrane protein-associated protein B/C (VAMP- associated protein B/C)(VAMP-B/VAMP-C)(VAP-B/VAP-C) VAPB ENSG00000124164 [Source:UniProtKB/Swiss-Prot;Acc:O95292] 5.99 7.05 1.06 2.09 1.36E-03 8.69E-03 2.69E-04 1.42E-03 1.06 3 hsa-miR-222,hsa-miR-27a,hsa-miR-424, Dual specificity protein phosphatase 16 (EC 3.1.3.48)(EC 3.1.3.16)(Mitogen-activated protein kinase phosphatase 7)(MAP kinase phosphatase 7)(MKP-7) [Source:UniProtKB/Swiss- DUSP16 ENSG00000111266 Prot;Acc:Q9BY84] 6.67 7.73 1.06 2.09 1.13E-05 1.75E-04 1.03E-05 7.58E-05 1.06 2 hsa-miR-21,hsa-miR-24, Calcium-transporting ATPase type 2C member 1 (ATPase 2C1)(EC 3.6.3.8)(ATP-dependent Ca(2+) pump PMR1) ATP2C1 ENSG00000017260 [Source:UniProtKB/Swiss-Prot;Acc:P98194] 6.18 7.25 1.06 2.09 6.50E-04 4.81E-03 4.74E-05 3.01E-04 1.12 2 hsa-miR-19a,hsa-miR-7, Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1)(TAR RNA-interacting protein)(GC-binding LRRFIP1 ENSG00000124831 factor 2) [Source:UniProtKB/Swiss-Prot;Acc:Q32MZ4] 6.47 7.54 1.07 2.09 3.01E-05 3.87E-04 1.41E-07 1.62E-06 1.10 2 hsa-miR-132,hsa-miR-19a, Protein disulfide-isomerase A3 Precursor (EC 5.3.4.1)(Disulfide isomerase ER-60)(ERp60)(58 kDa microsomal protein)(p58)(ERp57)(58 kDa glucose-regulated protein) PDIA3 ENSG00000167004 [Source:UniProtKB/Swiss-Prot;Acc:P30101] 8.29 9.36 1.07 2.09 1.90E-04 1.75E-03 2.74E-07 2.91E-06 1.33 1 hsa-miR-7, Zinc finger MYM-type protein 2 (Zinc finger protein 198)(Fused in myeloproliferative disorders protein)(Rearranged in atypical myeloproliferative disorder protein) [Source:UniProtKB/Swiss- ZMYM2 ENSG00000121741 Prot;Acc:Q9UBW7] 6.75 7.82 1.07 2.10 1.29E-03 8.34E-03 1.70E-03 7.30E-03 1.07 2 hsa-miR-155,hsa-miR-222, RNA-binding protein MEX3C (RING finger and KH domain- containing protein 2)(RING finger protein 194) MEX3C ENSG00000176624 [Source:UniProtKB/Swiss-Prot;Acc:Q5U5Q3] 7.85 8.92 1.07 2.10 4.65E-04 3.64E-03 8.65E-06 6.49E-05 1.07 3 hsa-miR-155,hsa-miR-200b,hsa-miR-365, BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A- transactivated protein 8)(HCV NS5A-transactivated protein 8) BTBD1 ENSG00000064726 [Source:UniProtKB/Swiss-Prot;Acc:Q9H0C5] 6.80 7.87 1.07 2.10 1.75E-04 1.64E-03 3.37E-05 2.20E-04 1.07 2 hsa-miR-155,hsa-miR-200b, Peptidyl-prolyl cis-trans isomerase, mitochondrial Precursor (PPIase)(Rotamase)(EC 5.2.1.8)(Cyclophilin F) PPIF ENSG00000108179 [Source:UniProtKB/Swiss-Prot;Acc:P30405] 7.00 8.07 1.07 2.10 3.18E-08 1.49E-06 4.46E-13 2.23E-11 1.50 2 hsa-miR-27a,hsa-miR-7, Uncharacterized protein C14orf142 [Source:UniProtKB/Swiss- C14orf142 ENSG00000170270 Prot;Acc:Q9BXV9] 5.96 7.04 1.07 2.10 1.34E-05 2.00E-04 9.41E-11 2.45E-09 1.83 1 hsa-miR-155, Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) TOR1AIP2 ENSG00000169905 [Source:UniProtKB/Swiss-Prot;Acc:Q8NFQ8] 5.79 6.86 1.07 2.11 3.38E-04 2.80E-03 1.33E-05 9.52E-05 1.28 2 hsa-miR-21,hsa-miR-218, Tubulin--tyrosine ligase-like protein 12 [Source:UniProtKB/Swiss- TTLL12 ENSG00000100304 Prot;Acc:Q14166] 6.31 7.38 1.08 2.11 1.52E-07 5.32E-06 7.20E-17 1.10E-14 2.12 2 hsa-miR-222,hsa-miR-7, Uncharacterized protein C3orf59 [Source:UniProtKB/Swiss- C3orf59 ENSG00000180611 Prot;Acc:Q8IYB1] 5.88 6.96 1.08 2.11 7.86E-05 8.47E-04 1.13E-05 8.27E-05 1.08 1 hsa-miR-19a, PRELI domain-containing protein 1, mitochondrial Precursor (Px19- like protein)(25 kDa protein of relevant evolutionary and lymphoid PRELID1 ENSG00000169230 interest) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y255] 7.73 8.81 1.08 2.11 4.30E-06 8.02E-05 5.33E-11 1.49E-09 1.84 1 hsa-miR-24, Mitochondrial ornithine transporter 1 (Solute carrier family 25 member SLC25A15 ENSG00000102743 15) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y619] 5.62 6.70 1.08 2.12 3.37E-08 1.56E-06 1.05E-14 8.55E-13 1.73 1 hsa-miR-7, Mitochondrial import inner membrane translocase subunit Tim17-B TIMM17B ENSG00000126768 [Source:UniProtKB/Swiss-Prot;Acc:O60830] 6.84 7.92 1.08 2.12 2.29E-05 3.10E-04 1.34E-09 2.52E-08 1.58 1 hsa-let-7f, Cell cycle checkpoint protein RAD1 (hRAD1)(EC 3.1.11.2)(DNA repair exonuclease rad1 homolog)(Rad1-like DNA damage checkpoint RAD1 ENSG00000113456 protein) [Source:UniProtKB/Swiss-Prot;Acc:O60671] 5.94 7.02 1.08 2.12 1.15E-05 1.77E-04 1.59E-09 2.94E-08 1.69 1 hsa-miR-155, Signal transducer and activator of transcription 5B STAT5B ENSG00000173757 [Source:UniProtKB/Swiss-Prot;Acc:P51692] 7.13 8.21 1.09 2.12 7.86E-04 5.61E-03 4.68E-04 2.34E-03 1.09 1 hsa-miR-19a, Selenide, water dikinase 1 (EC 2.7.9.3)(Selenophosphate synthetase 1)(Selenium donor protein 1) [Source:UniProtKB/Swiss- SEPHS1 ENSG00000086475 Prot;Acc:P49903] 7.01 8.10 1.09 2.12 4.47E-06 8.28E-05 1.91E-10 4.56E-09 1.50 2 hsa-miR-132,hsa-miR-155, Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha)(IkBKA)(IKK-alpha)(IKK-A)(IkappaB kinase)(EC 2.7.11.10)(I-kappa-B kinase 1)(IKK1)(Conserved helix-loop-helix CHUK ENSG00000213341 ubiquitous kinase)(Nuclear factor NF-kappa-B inhibitor kinase alp 5.42 6.50 1.09 2.12 6.14E-05 6.93E-04 3.84E-09 6.35E-08 1.78 1 hsa-let-7f, Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Precursor (EC 1.2.4.1)(PDHE1-A type I) PDHA1 ENSG00000131828 [Source:UniProtKB/Swiss-Prot;Acc:P08559] 6.67 7.76 1.09 2.12 6.68E-06 1.14E-04 5.48E-10 1.15E-08 1.63 1 hsa-miR-155, Serine/threonine-protein phosphatase 5 (PP5)(EC 3.1.3.16)(Protein phosphatase T)(PP-T)(PPT) [Source:UniProtKB/Swiss- PPP5C ENSG00000011485 Prot;Acc:P53041] 5.95 7.04 1.09 2.13 5.55E-05 6.38E-04 1.43E-11 4.62E-10 1.87 1 hsa-miR-365, Tetratricopeptide repeat protein 26 (TPR repeat protein 26) TTC26 ENSG00000105948 [Source:UniProtKB/Swiss-Prot;Acc:A0AVF1] 5.17 6.26 1.09 2.13 1.53E-07 5.35E-06 1.98E-11 6.20E-10 1.34 1 hsa-miR-7, WD repeat-containing protein 1 (Actin-interacting protein WDR1 ENSG00000071127 1)(AIP1)(NORI-1) [Source:UniProtKB/Swiss-Prot;Acc:O75083] 8.34 9.43 1.09 2.13 1.27E-03 8.28E-03 3.39E-05 2.21E-04 1.31 2 hsa-miR-19a,hsa-miR-218, E3 ubiquitin-protein ligase KCMF1 (EC 6.3.2.-)(Potassium channel modulatory factor)(PCMF)(FGF-induced in gastric cancer)(ZZ-type zinc finger-containing protein 1) [Source:UniProtKB/Swiss- KCMF1 ENSG00000176407 Prot;Acc:Q9P0J7] 7.50 8.59 1.09 2.13 1.05E-04 1.07E-03 3.20E-05 2.10E-04 1.09 5 hsa-miR-132,hsa-miR-18a,hsa-miR-200b,hsa-miR-24,hsa-miR-27a, Tumor protein D54 (hD54)(Tumor protein D52-like 2) TPD52L2 ENSG00000101150 [Source:UniProtKB/Swiss-Prot;Acc:O43399] 6.63 7.72 1.09 2.13 5.14E-06 9.25E-05 1.06E-09 2.03E-08 1.39 2 hsa-miR-210,hsa-miR-7, ETS domain-containing protein Elk-1 [Source:UniProtKB/Swiss- ELK1 ENSG00000126767 Prot;Acc:P19419] 6.50 7.59 1.09 2.13 8.86E-08 3.39E-06 3.79E-11 1.10E-09 1.23 1 hsa-miR-135b, Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)(p21-activated kinase 1)(PAK-1)(p65-PAK)(Alpha-PAK) [Source:UniProtKB/Swiss- PAK1 ENSG00000149269 Prot;Acc:Q13153] 5.76 6.85 1.09 2.13 7.77E-05 8.40E-04 6.03E-06 4.67E-05 1.17 3 hsa-miR-218,hsa-miR-221,hsa-miR-7, Low molecular weight phosphotyrosine protein phosphatase (LMW- PTPase)(LMW-PTP)(EC 3.1.3.48)(Low molecular weight cytosolic acid phosphatase)(EC 3.1.3.2)(Red cell acid phosphatase 1)(Adipocyte acid phosphatase) [Source:UniProtKB/Swiss- ACP1 ENSG00000143727 Prot;Acc:P24666] 7.32 8.41 1.09 2.13 2.98E-04 2.53E-03 8.58E-07 8.04E-06 1.29 1 hsa-let-7f, Ubiquinone biosynthesis protein COQ9, mitochondrial Precursor COQ9 ENSG00000088682 [Source:UniProtKB/Swiss-Prot;Acc:O75208] 6.46 7.56 1.09 2.13 1.10E-05 1.71E-04 4.00E-09 6.58E-08 1.40 1 hsa-miR-21, Ras GTPase-activating-like protein IQGAP1 (p195) IQGAP1 ENSG00000140575 [Source:UniProtKB/Swiss-Prot;Acc:P46940] 6.34 7.44 1.09 2.13 4.36E-04 3.45E-03 6.37E-04 3.08E-03 1.09 2 hsa-miR-24,hsa-miR-7, Putative methyltransferase NSUN4 (EC 2.1.1.-)(NOL1/NOP2/Sun domain family member 4) [Source:UniProtKB/Swiss- NSUN4 ENSG00000117481 Prot;Acc:Q96CB9] 6.15 7.24 1.10 2.14 1.40E-05 2.08E-04 4.79E-07 4.79E-06 1.31 2 hsa-miR-221,hsa-miR-7, Putative methyltransferase NSUN4 (EC 2.1.1.-)(NOL1/NOP2/Sun domain family member 4) [Source:UniProtKB/Swiss- NSUN4 ENSG00000117481 Prot;Acc:Q96CB9] 6.15 7.24 1.10 2.14 1.40E-05 2.08E-04 4.79E-07 4.79E-06 1.31 2 hsa-miR-221,hsa-miR-7, FAM113B ENSG00000179715 Protein FAM113B [Source:UniProtKB/Swiss-Prot;Acc:Q96HM7] 6.74 7.83 1.10 2.14 6.56E-04 4.84E-03 3.09E-05 2.04E-04 1.18 1 hsa-miR-7, TET2 ENSG00000168769 Protein TET2 [Source:UniProtKB/Swiss-Prot;Acc:Q6N021] 5.83 6.92 1.10 2.14 2.04E-04 1.86E-03 1.35E-04 7.69E-04 1.10 1 hsa-miR-221, Semaphorin-4A Precursor (Semaphorin-B)(Sema B) SEMA4A ENSG00000196189 [Source:UniProtKB/Swiss-Prot;Acc:Q9H3S1] 6.12 7.21 1.10 2.14 9.27E-10 8.30E-08 5.36E-11 1.49E-09 1.14 2 hsa-miR-218,hsa-miR-24,

Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1)(HIV-EP1)(Major histocompatibility complex-binding protein 1)(MBP-1)(Positive regulatory domain II-binding factor HIVEP1 ENSG00000095951 1)(PRDII-BF1) [Source:UniProtKB/Swiss-Prot;Acc:P15822] 6.35 7.45 1.10 2.14 1.17E-03 7.71E-03 3.32E-04 1.72E-03 1.10 1 hsa-miR-218, Chromodomain-helicase-DNA-binding protein 4 (CHD-4)(EC 3.6.1.- )(ATP-dependent helicase CHD4)(Mi-2 autoantigen 218 kDa CHD4 ENSG00000111642 protein)(Mi2-beta) [Source:UniProtKB/Swiss-Prot;Acc:Q14839] 7.33 8.42 1.10 2.14 1.83E-05 2.59E-04 9.01E-08 1.08E-06 1.26 1 hsa-miR-7, LETM1 domain-containing protein 1 (Cervical cancer 1 proto- oncogene protein p40)(Cervical cancer proto-oncogene 2 LETMD1 ENSG00000050426 protein)(HCRR-2) [Source:UniProtKB/Swiss-Prot;Acc:Q6P1Q0] 6.57 7.67 1.10 2.14 8.94E-04 6.23E-03 2.58E-04 1.37E-03 1.10 1 hsa-miR-132, M-phase inducer phosphatase 1 (EC 3.1.3.48)(Dual specificity CDC25A ENSG00000164045 phosphatase Cdc25A) [Source:UniProtKB/Swiss-Prot;Acc:P30304] 4.88 5.98 1.10 2.14 1.57E-07 5.45E-06 1.63E-18 4.51E-16 2.02 3 hsa-miR-155,hsa-miR-21,hsa-miR-365, La-related protein 2 (La ribonucleoprotein domain family member 2) LARP2 ENSG00000138709 [Source:UniProtKB/Swiss-Prot;Acc:Q659C4] 5.99 7.09 1.10 2.14 3.75E-05 4.60E-04 4.77E-07 4.78E-06 1.27 1 hsa-miR-7, Uncharacterized protein C1orf109 [Source:UniProtKB/Swiss- C1orf109 ENSG00000116922 Prot;Acc:Q9NX04] 6.09 7.19 1.10 2.14 4.95E-07 1.37E-05 3.15E-10 7.08E-09 1.23 2 hsa-miR-132,hsa-miR-200b, Spermatogenesis-associated protein 5-like protein 1 SPATA5L1 ENSG00000171763 [Source:UniProtKB/Swiss-Prot;Acc:Q9BVQ7] 5.47 6.57 1.10 2.15 6.02E-05 6.82E-04 1.50E-06 1.33E-05 1.21 1 hsa-miR-18a, Adenosine deaminase-like protein (EC 3.5.4.-) ADAL ENSG00000168803 [Source:UniProtKB/Swiss-Prot;Acc:Q6DHV7] 5.51 6.61 1.10 2.15 5.88E-06 1.03E-04 3.64E-08 4.79E-07 1.39 1 hsa-miR-24, Trimethylguanosine synthase homolog (EC 2.1.1.-)(Nuclear receptor coactivator 6-interacting protein)(PRIP-interacting protein with methyltransferase motif)(PIPMT)(PIMT)(CLL-associated antigen KW- TGS1 ENSG00000137574 2)(Hepatocellular carcinoma-associated antigen 137) [Source: 5.94 7.04 1.10 2.15 1.29E-03 8.33E-03 6.06E-06 4.69E-05 1.54 1 hsa-miR-7, Zinc finger protein 85 (Zinc finger protein HPF4)(HTF1) ZNF85 ENSG00000105750 [Source:UniProtKB/Swiss-Prot;Acc:Q03923] 6.55 7.66 1.10 2.15 5.31E-05 6.14E-04 5.55E-06 4.34E-05 1.10 2 hsa-miR-155,hsa-miR-18a, Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1)(Pim-2h) PIM2 ENSG00000102096 [Source:UniProtKB/Swiss-Prot;Acc:Q9P1W9] 7.86 8.97 1.10 2.15 1.30E-04 1.28E-03 3.01E-06 2.50E-05 1.10 2 hsa-miR-200b,hsa-miR-24, ZNF140 ENSG00000196387 Zinc finger protein 140 [Source:UniProtKB/Swiss-Prot;Acc:P52738] 5.35 6.45 1.10 2.15 1.50E-05 2.20E-04 9.18E-06 6.84E-05 1.10 1 hsa-miR-7, Uncharacterized protein C14orf133 [Source:UniProtKB/Swiss- C14orf133 ENSG00000151445 Prot;Acc:Q9H9C1] 5.91 7.01 1.10 2.15 1.56E-03 9.69E-03 1.74E-04 9.64E-04 1.10 1 hsa-miR-29b, Protein phosphatase PTC7 homolog (EC 3.1.3.16)(T-cell activation protein phosphatase 2C)(TA-PP2C)(T-cell activation protein PPTC7 ENSG00000196850 phosphatase 2C-like) [Source:UniProtKB/Swiss-Prot;Acc:Q8NI37] 7.00 8.11 1.10 2.15 7.33E-05 8.02E-04 1.12E-06 1.03E-05 1.10 2 hsa-miR-155,hsa-miR-19a, Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein)(hTIMAP)(CAAX box protein TIMAP)(Ankyrin repeat domain-containing protein 4) PPP1R16B ENSG00000101445 [Source:UniProtKB/Swiss-Prot;Acc:Q96T49] 7.22 8.32 1.10 2.15 8.14E-07 2.07E-05 2.92E-09 5.02E-08 1.10 1 hsa-miR-365, Transmembrane 9 superfamily member 4 Precursor TM9SF4 ENSG00000101337 [Source:UniProtKB/Swiss-Prot;Acc:Q92544] 6.89 7.99 1.10 2.15 2.55E-05 3.37E-04 1.76E-07 1.97E-06 1.18 1 hsa-miR-218, Frizzled-6 Precursor (Fz-6)(hFz6) [Source:UniProtKB/Swiss- FZD6 ENSG00000164930 Prot;Acc:O60353] 5.46 6.57 1.11 2.15 2.10E-04 1.90E-03 7.08E-05 4.30E-04 1.33 3 hsa-miR-130b,hsa-miR-132,hsa-miR-19a, Deoxycytidylate deaminase (EC 3.5.4.12)(dCMP deaminase) DCTD ENSG00000129187 [Source:UniProtKB/Swiss-Prot;Acc:P32321] 7.86 8.96 1.11 2.15 4.09E-05 4.94E-04 8.88E-09 1.35E-07 1.50 1 hsa-miR-7, B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein)(Bcl- 9)(Protein legless homolog) [Source:UniProtKB/Swiss- BCL9 ENSG00000116128 Prot;Acc:O00512] 6.12 7.23 1.11 2.15 1.50E-06 3.44E-05 1.59E-09 2.92E-08 1.25 2 hsa-miR-200b,hsa-miR-218, Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase- activating protein 130 kDa subunit)(Rab3-GAP p130)(Rab3-GAP) RAB3GAP1 ENSG00000115839 [Source:UniProtKB/Swiss-Prot;Acc:Q15042] 6.31 7.41 1.11 2.15 6.81E-04 5.00E-03 2.34E-04 1.26E-03 1.11 1 hsa-miR-155, Ras-related protein Rab-11A (Rab-11)(YL8) RAB11A ENSG00000103769 [Source:UniProtKB/Swiss-Prot;Acc:P62491] 7.56 8.67 1.11 2.15 1.01E-03 6.83E-03 5.10E-05 3.22E-04 1.27 1 hsa-miR-7, Uncharacterized protein KIAA0247 Precursor KIAA0247 ENSG00000100647 [Source:UniProtKB/Swiss-Prot;Acc:Q92537] 6.80 7.91 1.11 2.15 7.35E-05 8.03E-04 7.03E-05 4.27E-04 1.11 5 hsa-miR-18a,hsa-miR-21,hsa-miR-24,hsa-miR-27a,hsa-miR-7, 7-dehydrocholesterol reductase (7-DHC reductase)(EC 1.3.1.21)(Sterol Delta(7)-reductase)(Putative sterol reductase SR-2) DHCR7 ENSG00000172893 [Source:UniProtKB/Swiss-Prot;Acc:Q9UBM7] 6.21 7.32 1.11 2.15 6.22E-06 1.07E-04 1.72E-15 1.75E-13 2.24 1 hsa-miR-7, 39S ribosomal protein L19, mitochondrial Precursor (L19mt)(MRP- MRPL19 ENSG00000115364 L19)(MRP-L15) [Source:UniProtKB/Swiss-Prot;Acc:P49406] 5.96 7.07 1.11 2.16 1.73E-04 1.63E-03 1.03E-08 1.55E-07 1.80 4 hsa-miR-155,hsa-miR-18a,hsa-miR-365,hsa-miR-7, ADP-ribosylation factor 6 [Source:UniProtKB/Swiss- ARF6 ENSG00000165527 Prot;Acc:P62330] 8.91 10.02 1.11 2.16 7.09E-05 7.79E-04 1.31E-06 1.18E-05 1.11 2 hsa-miR-218,hsa-miR-27a, Protein VPRBP (HIV-1 Vpr-binding protein)(VprBP)(Vpr-interacting protein)(DDB1- and CUL4-associated factor 1) VPRBP ENSG00000145041 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y4B6] 6.56 7.67 1.11 2.16 1.80E-05 2.55E-04 1.21E-08 1.78E-07 1.41 2 hsa-miR-18a,hsa-miR-7, Nurim (Nuclear rim protein)(Nuclear envelope membrane protein) NRM ENSG00000137404 [Source:UniProtKB/Swiss-Prot;Acc:Q8IXM6] 5.65 6.77 1.11 2.16 2.35E-07 7.59E-06 2.48E-10 5.73E-09 1.28 1 hsa-miR-132, Pantothenate kinase 2, mitochondrial Precursor (EC 2.7.1.33)(Pantothenic acid kinase 2)(hPANK2) PANK2 ENSG00000125779 [Source:UniProtKB/Swiss-Prot;Acc:Q9BZ23] 6.29 7.40 1.11 2.16 6.49E-04 4.80E-03 2.40E-05 1.63E-04 1.20 1 hsa-miR-155, HEAT repeat-containing protein 5A [Source:UniProtKB/Swiss- HEATR5A ENSG00000129493 Prot;Acc:Q86XA9] 5.59 6.70 1.11 2.17 5.44E-05 6.26E-04 8.08E-05 4.83E-04 1.11 1 hsa-miR-18a, Nucleosome assembly protein 1-like 1 (NAP-1-related NAP1L1 ENSG00000187109 protein)(hNRP) [Source:UniProtKB/Swiss-Prot;Acc:P55209] 8.54 9.65 1.12 2.17 2.34E-04 2.08E-03 2.61E-06 2.20E-05 1.21 2 hsa-miR-132,hsa-miR-222, Protein CIAO1 (WD repeat-containing protein 39) CIAO1 ENSG00000144021 [Source:UniProtKB/Swiss-Prot;Acc:O76071] 6.93 8.05 1.12 2.17 3.27E-05 4.13E-04 4.62E-09 7.49E-08 1.46 1 hsa-miR-155, Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-)(DEAD box protein 52)(ATP-dependent RNA helicase ROK1-like) DDX52 ENSG00000141141 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2R4] 6.25 7.37 1.12 2.17 5.21E-04 4.01E-03 1.48E-06 1.32E-05 1.49 1 hsa-miR-21, Cyclic AMP-responsive element-binding protein 1 (cAMP-responsive element-binding protein 1)(CREB-1) [Source:UniProtKB/Swiss- CREB1 ENSG00000118260 Prot;Acc:P16220] 7.29 8.41 1.12 2.17 1.21E-03 7.96E-03 8.54E-04 4.00E-03 1.12 3 hsa-miR-155,hsa-miR-27a,hsa-miR-7, cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1)(TSE1) [Source:UniProtKB/Swiss- PRKAR1A ENSG00000108946 Prot;Acc:P10644] 7.64 8.76 1.12 2.17 6.87E-05 7.59E-04 6.47E-08 8.07E-07 1.12 2 hsa-miR-155,hsa-miR-200b, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Precursor (EC 2.4.1.119)(Dolichyl- diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit)(Ribophorin-1)(Ribophorin I)(RPN-I) RPN1 ENSG00000163902 [Source:UniProtKB/Swiss-Prot;Acc:P04843] 7.33 8.45 1.12 2.18 1.10E-04 1.11E-03 1.87E-06 1.63E-05 1.30 1 hsa-miR-27a, Natural resistance-associated macrophage protein 2 (NRAMP 2)(Divalent metal transporter 1)(DMT1) [Source:UniProtKB/Swiss- SLC11A2 ENSG00000110911 Prot;Acc:P49281] 6.35 7.48 1.12 2.18 4.23E-05 5.07E-04 1.06E-07 1.25E-06 1.15 3 hsa-miR-155,hsa-miR-19a,hsa-miR-24, Mitochondrial import inner membrane translocase subunit TIM50 TIMM50 ENSG00000105197 Precursor [Source:UniProtKB/Swiss-Prot;Acc:Q3ZCQ8] 7.45 8.57 1.12 2.18 1.63E-06 3.67E-05 4.21E-12 1.58E-10 1.78 1 hsa-miR-7, AFTPH ENSG00000119844 Aftiphilin [Source:UniProtKB/Swiss-Prot;Acc:Q6ULP2] 7.36 8.49 1.12 2.18 9.82E-05 1.02E-03 4.34E-06 3.49E-05 1.12 1 hsa-miR-19a, Histone deacetylase 7 (HD7)(EC 3.5.1.98)(HD7a) HDAC7 ENSG00000061273 [Source:UniProtKB/Swiss-Prot;Acc:Q8WUI4] 7.00 8.13 1.12 2.18 5.17E-06 9.28E-05 5.67E-07 5.57E-06 1.12 1 hsa-miR-19a, Phosphatidic acid phosphatase type 2 domain-containing protein 1B PPAPDC1B ENSG00000147535 (EC 3.1.3.-) [Source:UniProtKB/Swiss-Prot;Acc:Q8NEB5] 6.23 7.35 1.12 2.18 3.92E-06 7.44E-05 1.68E-07 1.89E-06 1.12 1 hsa-miR-18a, Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198)(GlcNAc-PI synthesis protein)(Phosphatidylinositol-glycan biosynthesis class A protein)(PIG-A) [Source:UniProtKB/Swiss- PIGA ENSG00000165195 Prot;Acc:P37287] 6.60 7.72 1.13 2.18 6.81E-04 4.99E-03 7.57E-05 4.56E-04 1.13 3 hsa-miR-130b,hsa-miR-221,hsa-miR-365, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a)(eRF3a)(G1 to S phase transition protein 1 homolog) [Source:UniProtKB/Swiss- GSPT1 ENSG00000103342 Prot;Acc:P15170] 7.48 8.60 1.13 2.18 1.64E-04 1.55E-03 2.71E-06 2.27E-05 1.43 1 hsa-miR-27a, Transcription factor E2F5 (E2F-5) [Source:UniProtKB/Swiss- E2F5 ENSG00000133740 Prot;Acc:Q15329] 5.60 6.72 1.13 2.18 6.02E-07 1.62E-05 6.35E-10 1.32E-08 1.33 1 hsa-miR-132, Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43)(Suppressor of variegation 3-9 homolog 1)(Su(var)3-9 homolog 1)(Position-effect variegation 3-9 homolog)(Histone H3-K9 methyltransferase 1)(H3-K9-HMTase 1)(Lysine N-methyltransferase SUV39H1 ENSG00000101945 1A) [Source:UniP 5.47 6.60 1.13 2.18 4.08E-07 1.17E-05 2.80E-11 8.38E-10 1.43 1 hsa-miR-19a, ZNF100 ENSG00000197020 Zinc finger protein 100 [Source:UniProtKB/Swiss-Prot;Acc:Q8IYN0] 5.87 6.99 1.13 2.18 8.49E-04 5.97E-03 1.78E-03 7.61E-03 1.13 2 hsa-miR-155,hsa-miR-18a, Small nuclear ribonucleoprotein G (snRNP-G)(Sm protein G)(Sm- SNRPG ENSG00000143977 G)(SmG) [Source:UniProtKB/Swiss-Prot;Acc:P62308] 7.15 8.28 1.13 2.18 7.34E-05 8.03E-04 2.81E-08 3.79E-07 1.76 1 hsa-miR-155, Chromobox protein homolog 6 [Source:UniProtKB/Swiss- CBX6 ENSG00000183741 Prot;Acc:O95503] 6.50 7.62 1.13 2.18 2.49E-07 7.93E-06 1.17E-12 5.18E-11 1.42 2 hsa-miR-29b,hsa-miR-7, Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in PEA15 ENSG00000162734 diabetes)(PED) [Source:UniProtKB/Swiss-Prot;Acc:Q15121] 6.43 7.56 1.13 2.18 1.71E-07 5.83E-06 1.29E-11 4.25E-10 1.63 5 hsa-miR-132,hsa-miR-155,hsa-miR-19a,hsa-miR-24,hsa-miR-7, Importin subunit alpha-3 (Karyopherin subunit alpha-3)(SRP1- gamma)(Importin alpha Q2)(Qip2) [Source:UniProtKB/Swiss- KPNA3 ENSG00000102753 Prot;Acc:O00505] 6.35 7.48 1.13 2.18 3.57E-04 2.93E-03 7.24E-09 1.12E-07 1.86 3 hsa-miR-19a,hsa-miR-24,hsa-miR-27a, Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 NIPA1 ENSG00000170113 [Source:UniProtKB/Swiss-Prot;Acc:Q7RTP0] 7.47 8.60 1.13 2.19 6.63E-08 2.71E-06 7.30E-12 2.57E-10 1.30 5 hsa-miR-130b,hsa-miR-155,hsa-miR-19a,hsa-miR-222,hsa-miR-7, Translocon-associated protein subunit alpha Precursor (TRAP- alpha)(Signal sequence receptor subunit alpha)(SSR-alpha) hsa-miR-135b,hsa-miR-155,hsa-miR-21,hsa-miR-218,hsa-miR-24,hsa-miR-365,hsa- SSR1 ENSG00000124783 [Source:UniProtKB/Swiss-Prot;Acc:P43307] 7.66 8.79 1.13 2.19 9.09E-04 6.32E-03 4.79E-05 3.04E-04 1.28 7 miR-7, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B)(EC 3.1.4.17)(63 kDa Cam- PDE1B ENSG00000123360 PDE) [Source:UniProtKB/Swiss-Prot;Acc:Q01064] 5.75 6.88 1.13 2.19 9.20E-11 1.31E-08 3.98E-11 1.15E-09 1.13 1 hsa-miR-18a, Proteasome subunit alpha type-2 (EC 3.4.25.1)(Proteasome component C3)(Macropain subunit C3)(Multicatalytic endopeptidase PSMA2 ENSG00000106588 complex subunit C3) [Source:UniProtKB/Swiss-Prot;Acc:P25787] 7.32 8.45 1.13 2.19 3.52E-04 2.90E-03 8.17E-07 7.70E-06 1.78 1 hsa-miR-132, Thioredoxin-like protein 4B (Dim1-like protein) TXNL4B ENSG00000140830 [Source:UniProtKB/Swiss-Prot;Acc:Q9NX01] 5.79 6.92 1.13 2.19 4.13E-04 3.30E-03 3.64E-06 2.97E-05 1.30 2 hsa-miR-18a,hsa-miR-7, Protein dpy-19 homolog 2 (Dpy-19-like protein 2) DPY19L2 ENSG00000177990 [Source:UniProtKB/Swiss-Prot;Acc:Q6NUT2] 5.01 6.15 1.14 2.20 5.06E-04 3.91E-03 1.31E-05 9.44E-05 1.60 1 hsa-miR-155, Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A)(EC 5.2.1.8)(FK506-binding protein 1A)(FKBP- 1A)(Rotamase)(Immunophilin FKBP12)(12 kDa FKBP)(FKBP-12) FKBP1A ENSG00000088832 [Source:UniProtKB/Swiss-Prot;Acc:P62942] 7.35 8.48 1.14 2.20 6.38E-07 1.69E-05 1.74E-11 5.52E-10 1.76 3 hsa-miR-135b,hsa-miR-218,hsa-miR-424, Methyltransferase-like protein 10 (EC 2.1.1.-) METTL10 ENSG00000203791 [Source:UniProtKB/Swiss-Prot;Acc:Q5JPI9] 5.97 7.11 1.14 2.20 9.45E-04 6.51E-03 3.61E-04 1.86E-03 1.14 1 hsa-miR-222, Hsc70-interacting protein (Hip)(Suppression of tumorigenicity protein 13)(Putative tumor suppressor ST13)(Protein FAM10A1)(Progesterone receptor-associated p48 protein)(Renal carcinoma antigen NY-REN-33) [Source:UniProtKB/Swiss- ST13 ENSG00000100380 Prot;Acc:P50502] 7.82 8.96 1.14 2.20 5.50E-04 4.19E-03 5.72E-06 4.46E-05 1.40 1 hsa-miR-18a, E3 ubiquitin-protein ligase ZNRF1 (EC 6.3.2.-)(Zinc/RING finger protein 1)(Nerve injury-induced gene 283 protein) ZNRF1 ENSG00000186187 [Source:UniProtKB/Swiss-Prot;Acc:Q8ND25] 5.85 6.99 1.14 2.20 2.83E-10 3.17E-08 4.40E-14 3.01E-12 1.15 2 hsa-miR-365,hsa-miR-7, Zinc finger protein 106 homolog (Zfp-106)(Zinc finger protein 474) ZFP106 ENSG00000103994 [Source:UniProtKB/Swiss-Prot;Acc:Q9H2Y7] 5.68 6.83 1.14 2.20 2.11E-04 1.91E-03 1.02E-04 5.94E-04 1.14 2 hsa-miR-27a,hsa-miR-7, Protein CASC3 (Cancer susceptibility candidate gene 3 protein)(Metastatic lymph node protein 51)(Protein MLN 51)(Protein CASC3 ENSG00000108349 barentsz)(Btz) [Source:UniProtKB/Swiss-Prot;Acc:O15234] 7.13 8.28 1.14 2.21 4.90E-05 5.75E-04 3.49E-07 3.60E-06 1.14 1 hsa-miR-27a, Transmembrane protein C9orf123 [Source:UniProtKB/Swiss- C9orf123 ENSG00000137038 Prot;Acc:Q96GE9] 6.14 7.28 1.14 2.21 7.56E-05 8.22E-04 2.61E-06 2.20E-05 1.28 3 hsa-miR-155,hsa-miR-18a,hsa-miR-7, Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4)(EC 2.7.12.2)(JNK-activating kinase 1)(c-Jun N-terminal kinase kinase 1)(JNKK)(SAPK/ERK kinase 1)(SEK1) MAP2K4 ENSG00000065559 [Source:UniProtKB/Swiss-Prot;Acc:P45985] 6.21 7.35 1.14 2.21 1.21E-03 7.93E-03 5.06E-05 3.19E-04 1.33 3 hsa-miR-218,hsa-miR-221,hsa-miR-27a, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme)(iPFK-2)(Renal carcinoma antigen NY-REN-56) [Includes 6-phosphofructo-2-kinase(EC 2.7.1.105);Fructose-2,6-bisphosphatase(EC 3.1.3.46)] PFKFB3 ENSG00000170525 [Source:UniProt 6.85 8.00 1.15 2.21 7.24E-06 1.21E-04 2.84E-06 2.37E-05 1.15 1 hsa-miR-19a, Dual specificity protein phosphatase 3 (EC 3.1.3.48)(EC 3.1.3.16)(Dual specificity protein phosphatase VHR) DUSP3 ENSG00000108861 [Source:UniProtKB/Swiss-Prot;Acc:P51452] 5.52 6.67 1.15 2.21 5.12E-05 5.96E-04 2.93E-07 3.09E-06 1.33 1 hsa-miR-221, Cytoplasmic dynein 1 light intermediate chain 1 (Dynein light intermediate chain 1, cytosolic)(Dynein light chain A)(DLC-A) DYNC1LI1 ENSG00000144635 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y6G9] 6.53 7.67 1.15 2.22 1.47E-03 9.24E-03 1.18E-06 1.08E-05 1.75 1 hsa-miR-218, Methyltransferase-like protein 6 (EC 2.1.1.-) METTL6 ENSG00000206562 [Source:UniProtKB/Swiss-Prot;Acc:Q8TCB7] 5.40 6.55 1.15 2.22 1.09E-05 1.70E-04 1.21E-07 1.42E-06 1.15 2 hsa-miR-221,hsa-miR-7, Aryl hydrocarbon receptor Precursor (Ah receptor)(AhR)(Class E basic helix-loop-helix protein 76)(bHLHe76) [Source:UniProtKB/Swiss- AHR ENSG00000106546 Prot;Acc:P35869] 6.70 7.85 1.15 2.22 9.66E-04 6.61E-03 1.89E-03 8.00E-03 1.15 1 hsa-miR-7, Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)(Protein-tyrosine phosphatase 2C)(PTP-2C)(PTP-1D)(SH- PTP3)(SH-PTP2)(SHP-2)(Shp2) [Source:UniProtKB/Swiss- PTPN11 ENSG00000179295 Prot;Acc:Q06124] 5.95 7.10 1.15 2.22 1.14E-06 2.73E-05 5.25E-10 1.11E-08 1.65 3 hsa-miR-155,hsa-miR-200b,hsa-miR-218, Uncharacterized protein KIAA2032 [Source:UniProtKB/Swiss- C13orf23 ENSG00000120685 Prot;Acc:Q86XN7] 5.84 6.99 1.15 2.22 9.16E-06 1.47E-04 2.41E-07 2.60E-06 1.24 2 hsa-miR-21,hsa-miR-29b, SUMO-conjugating enzyme UBC9 (EC 6.3.2.-)(SUMO-protein ligase)(Ubiquitin-conjugating enzyme E2 I)(Ubiquitin-protein ligase I)(Ubiquitin carrier protein I)(Ubiquitin carrier protein 9)(p18) UBE2I ENSG00000103275 [Source:UniProtKB/Swiss-Prot;Acc:P63279] 7.01 8.16 1.15 2.22 1.43E-05 2.12E-04 1.00E-08 1.50E-07 1.25 2 hsa-miR-200b,hsa-miR-7, Citrate synthase, mitochondrial Precursor (EC 2.3.3.1) CS ENSG00000062485 [Source:UniProtKB/Swiss-Prot;Acc:O75390] 7.44 8.60 1.16 2.23 2.19E-05 2.98E-04 3.05E-09 5.22E-08 1.66 3 hsa-miR-155,hsa-miR-19a,hsa-miR-365, Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1)(Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1)(SPFH domain-containing protein 1)(Protein KE04) ERLIN1 ENSG00000107566 [Source:UniProtKB/Swiss-Prot;Acc:O75477] 6.01 7.16 1.16 2.23 9.13E-07 2.26E-05 7.77E-10 1.56E-08 1.16 3 hsa-miR-19a,hsa-miR-200b,hsa-miR-7, Protein numb homolog (h-Numb)(Protein S171) NUMB ENSG00000133961 [Source:UniProtKB/Swiss-Prot;Acc:P49757] 5.87 7.02 1.16 2.23 1.33E-05 1.98E-04 1.81E-07 2.02E-06 1.16 2 hsa-miR-200b,hsa-miR-218, ZNF292 ENSG00000188994 Zinc finger protein 292 [Source:UniProtKB/Swiss-Prot;Acc:O60281] 6.78 7.94 1.16 2.23 1.13E-03 7.52E-03 2.33E-03 9.58E-03 1.16 1 hsa-miR-200b, Beta-centractin (Actin-related protein 1B)(ARP1B) ACTR1B ENSG00000115073 [Source:UniProtKB/Swiss-Prot;Acc:P42025] 6.78 7.93 1.16 2.23 4.77E-04 3.72E-03 7.31E-05 4.42E-04 1.16 1 hsa-miR-7, NAD(P) transhydrogenase, mitochondrial Precursor (EC 1.6.1.2)(Nicotinamide nucleotide transhydrogenase)(Pyridine nucleotide transhydrogenase) [Source:UniProtKB/Swiss- NNT ENSG00000112992 Prot;Acc:Q13423] 6.89 8.05 1.16 2.23 2.07E-04 1.88E-03 7.41E-05 4.48E-04 1.16 1 hsa-miR-222, Transmembrane protein 85 (Cell proliferation-inducing gene 17 TMEM85 ENSG00000128463 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q5J8M3] 7.84 9.00 1.16 2.23 1.85E-04 1.71E-03 7.07E-08 8.73E-07 1.50 1 hsa-miR-424, Zinc finger protein 257 (Bone marrow zinc finger 4)(BMZF-4) ZNF257 ENSG00000197134 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2Q1] 7.11 8.27 1.16 2.23 6.95E-04 5.08E-03 3.04E-04 1.59E-03 1.16 1 hsa-miR-155, Heterogeneous nuclear ribonucleoprotein R (hnRNP R) HNRNPR ENSG00000125944 [Source:UniProtKB/Swiss-Prot;Acc:O43390] 8.13 9.29 1.16 2.23 3.63E-04 2.97E-03 1.05E-06 9.69E-06 1.55 1 hsa-miR-132, PR domain zinc finger protein 1 (PR domain-containing protein 1)(Beta-interferon gene positive regulatory domain I-binding factor)(BLIMP-1)(Positive regulatory domain I-binding factor 1)(PRDI- PRDM1 ENSG00000057657 binding factor 1)(PRDI-BF1) [Source:UniProtKB/Swiss-Prot;Acc:O7 7.09 8.25 1.16 2.24 3.64E-05 4.49E-04 2.23E-06 1.91E-05 1.16 4 hsa-miR-200b,hsa-miR-221,hsa-miR-24,hsa-miR-365, Ubiquitin domain-containing protein UBFD1 (Ubiquitin-binding UBFD1 ENSG00000103353 protein homolog) [Source:UniProtKB/Swiss-Prot;Acc:O14562] 6.30 7.46 1.16 2.24 8.25E-07 2.09E-05 2.74E-11 8.23E-10 1.51 5 hsa-miR-155,hsa-miR-19a,hsa-miR-24,hsa-miR-27a,hsa-miR-7, Interferon-inducible double stranded RNA-dependent protein kinase activator A (Protein kinase, interferon-inducible double stranded RNA- dependent activator)(Protein activator of the interferon-induced protein PRKRA ENSG00000180228 kinase)(PKR-associated protein X)(PKR-associat 7.02 8.19 1.16 2.24 6.36E-04 4.72E-03 2.34E-05 1.59E-04 1.37 1 hsa-miR-221, Tumor necrosis factor Precursor (TNF-alpha)(Tumor necrosis factor ligand superfamily member 2)(TNF-a)(Cachectin) [Contains Tumor necrosis factor, membrane form;Tumor necrosis factor, soluble form] TNF ENSG00000232810 [Source:UniProtKB/Swiss-Prot;Acc:P01375] 5.47 6.63 1.16 2.24 2.71E-07 8.49E-06 7.71E-11 2.04E-09 2.25 1 hsa-miR-19b, Histone-binding protein RBBP4 (Retinoblastoma-binding protein 4)(RBBP-4)(Retinoblastoma-binding protein p48)(Chromatin assembly factor 1 subunit C)(CAF-1 subunit C)(Chromatin assembly factor I p48 subunit)(CAF-I 48 kDa subunit)(CAF-I p48)(Nucleosome- RBBP4 ENSG00000162521 remod 7.42 8.59 1.17 2.24 1.59E-04 1.51E-03 2.66E-07 2.83E-06 1.58 2 hsa-miR-24,hsa-miR-27a, C-X-C chemokine receptor type 5 (CXC-R5)(CXCR-5)(Burkitt lymphoma receptor 1)(Monocyte-derived receptor 15)(MDR- CXCR5 ENSG00000160683 15)(CD185 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P32302] 6.27 7.43 1.17 2.24 9.48E-04 6.52E-03 5.09E-05 3.21E-04 1.28 1 hsa-miR-18a, AMP deaminase 3 (EC 3.5.4.6)(AMP deaminase isoform E)(Erythrocyte AMP deaminase) [Source:UniProtKB/Swiss- AMPD3 ENSG00000133805 Prot;Acc:Q01432] 6.08 7.24 1.17 2.25 4.56E-05 5.43E-04 3.13E-05 2.06E-04 1.17 2 hsa-miR-218,hsa-miR-27a, Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113)(Processing alpha-1,2-mannosidase IA)(Alpha-1,2- mannosidase IA)(Mannosidase alpha class 1A member 1)(Man(9)- alpha-mannosidase)(Man9-mannosidase) [Source:UniProtKB/Swiss- MAN1A1 ENSG00000111885 Prot;Acc:P33908] 6.49 7.66 1.17 2.25 1.78E-04 1.66E-03 1.14E-05 8.34E-05 1.27 1 hsa-miR-7, E3 ubiquitin-protein ligase MIB1 (EC 6.3.2.-)(Mind bomb homolog 1)(DAPK-interacting protein 1)(DIP-1)(Zinc finger ZZ type with ankyrin repeat domain protein 2) [Source:UniProtKB/Swiss- MIB1 ENSG00000101752 Prot;Acc:Q86YT6] 6.18 7.35 1.17 2.25 4.39E-04 3.47E-03 1.28E-04 7.31E-04 1.17 3 hsa-let-7f,hsa-miR-19a,hsa-miR-7, Protein FAN (Factor associated with neutral sphingomyelinase activation)(Factor associated with N-SMase activation) NSMAF ENSG00000035681 [Source:UniProtKB/Swiss-Prot;Acc:Q92636] 6.41 7.58 1.17 2.25 3.38E-04 2.80E-03 1.08E-05 7.91E-05 1.28 2 hsa-miR-363,hsa-miR-7, Tribbles homolog 1 (TRB-1)(SKIP1)(G-protein-coupled receptor- induced protein 2)(GIG-2) [Source:UniProtKB/Swiss- TRIB1 ENSG00000173334 Prot;Acc:Q96RU8] 6.16 7.33 1.17 2.25 3.99E-07 1.15E-05 3.14E-09 5.36E-08 1.17 2 hsa-miR-132,hsa-miR-99b, Autophagy-related protein 3 (APG3-like)(hApg3)(Protein PC3-96) ATG3 ENSG00000144848 [Source:UniProtKB/Swiss-Prot;Acc:Q9NT62] 6.81 7.98 1.17 2.25 6.76E-04 4.96E-03 9.55E-07 8.85E-06 1.64 1 hsa-miR-155, Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22)(Nucleoside diphosphate-linked moiety X motif 12)(Nudix NUDT12 ENSG00000112874 motif 12) [Source:UniProtKB/Swiss-Prot;Acc:Q9BQG2] 4.52 5.70 1.17 2.26 2.54E-05 3.37E-04 9.41E-10 1.84E-08 1.90 2 hsa-miR-155,hsa-miR-200b, SEC23-interacting protein (p125) [Source:UniProtKB/Swiss- SEC23IP ENSG00000107651 Prot;Acc:Q9Y6Y8] 6.59 7.76 1.17 2.26 7.31E-05 8.00E-04 1.10E-08 1.64E-07 1.72 1 hsa-miR-221, Protein transport protein Sec24C (SEC24-related protein C) SEC24C ENSG00000176986 [Source:UniProtKB/Swiss-Prot;Acc:P53992] 6.65 7.83 1.17 2.26 1.41E-05 2.09E-04 7.48E-08 9.18E-07 1.18 3 hsa-miR-363,hsa-miR-7,hsa-miR-98, Transmembrane protein 87B Precursor [Source:UniProtKB/Swiss- TMEM87B ENSG00000153214 Prot;Acc:Q96K49] 6.24 7.42 1.18 2.26 3.24E-04 2.71E-03 4.61E-04 2.31E-03 1.18 2 hsa-miR-200b,hsa-miR-424, Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) STAT1 ENSG00000115415 [Source:UniProtKB/Swiss-Prot;Acc:P42224] 7.88 9.05 1.18 2.26 1.58E-03 9.79E-03 6.83E-05 4.16E-04 1.35 1 hsa-miR-155, CTNS ENSG00000040531 Cystinosin [Source:UniProtKB/Swiss-Prot;Acc:O60931] 5.50 6.68 1.18 2.26 8.10E-07 2.07E-05 1.24E-10 3.12E-09 1.51 1 hsa-miR-24, Serine/threonine-protein kinase 38-like (EC 2.7.11.1)(NDR2 protein kinase)(Nuclear Dbf2-related kinase 2) [Source:UniProtKB/Swiss- STK38L ENSG00000211455 Prot;Acc:Q9Y2H1] 5.99 7.17 1.18 2.26 3.75E-04 3.05E-03 1.03E-05 7.60E-05 1.23 6 hsa-miR-132,hsa-miR-155,hsa-miR-221,hsa-miR-29b,hsa-miR-365,hsa-miR-7, Palmitoyltransferase ZDHHC9 (EC 2.3.1.-)(Zinc finger DHHC domain-containing protein 9)(DHHC-9)(DHHC9)(Zinc finger protein ZDHHC9 ENSG00000188706 379) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y397] 5.62 6.80 1.18 2.26 1.36E-07 4.87E-06 6.58E-10 1.35E-08 1.18 1 hsa-miR-7, Transmembrane protein 165 (Transmembrane protein TPARL)(Transmembrane protein PT27) [Source:UniProtKB/Swiss- TMEM165 ENSG00000134851 Prot;Acc:Q9HC07] 6.62 7.80 1.18 2.26 3.27E-05 4.13E-04 1.19E-09 2.26E-08 1.70 2 hsa-miR-222,hsa-miR-24, Gigaxonin (Kelch-like protein 16) [Source:UniProtKB/Swiss- GAN ENSG00000127688 Prot;Acc:Q9H2C0] 6.00 7.18 1.18 2.26 4.89E-06 8.88E-05 1.16E-07 1.36E-06 1.18 4 hsa-let-7f,hsa-miR-200b,hsa-miR-218,hsa-miR-363, WD repeat-containing protein 68 (WD repeat-containing protein An11 hsa-miR-132,hsa-miR-155,hsa-miR-19a,hsa-miR-21,hsa-miR-221,hsa-miR-365,hsa- WDR68 ENSG00000136485 homolog) [Source:UniProtKB/Swiss-Prot;Acc:P61962] 7.35 8.53 1.18 2.26 1.71E-05 2.45E-04 1.36E-07 1.57E-06 1.24 7 miR-7, KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62)(GAP- associated tyrosine phosphoprotein p62)(Src-associated in mitosis 68 KHDRBS1 ENSG00000121774 kDa protein)(Sam68)(p68) [Source:UniProtKB/Swiss-Prot;A 7.89 9.08 1.18 2.27 1.01E-04 1.04E-03 1.73E-07 1.94E-06 1.27 3 hsa-miR-18a,hsa-miR-200b,hsa-miR-218, Vacuolar protein sorting-associated protein 37A (hVps37A)(ESCRT-I complex subunit VPS37A)(Hepatocellular carcinoma-related protein VPS37A ENSG00000155975 1) [Source:UniProtKB/Swiss-Prot;Acc:Q8NEZ2] 6.44 7.62 1.18 2.27 6.06E-05 6.85E-04 3.15E-07 3.28E-06 1.34 1 hsa-miR-19a, HBS1-like protein (ERFS) [Source:UniProtKB/Swiss- HBS1L ENSG00000112339 Prot;Acc:Q9Y450] 6.48 7.66 1.18 2.27 1.50E-03 9.39E-03 3.29E-04 1.71E-03 1.18 1 hsa-miR-363, LON peptidase N-terminal domain and RING finger protein 1 (RING LONRF1 ENSG00000154359 finger protein 191) [Source:UniProtKB/Swiss-Prot;Acc:Q17RB8] 6.33 7.51 1.18 2.27 2.95E-06 5.96E-05 1.33E-09 2.51E-08 1.43 2 hsa-miR-19a,hsa-miR-27a, Bcl-2-like protein 12 (Bcl2-L-12)(Bcl-2-related proline-rich protein) BCL2L12 ENSG00000126453 [Source:UniProtKB/Swiss-Prot;Acc:Q9HB09] 6.30 7.49 1.18 2.27 6.40E-09 4.08E-07 1.42E-10 3.51E-09 1.31 1 hsa-miR-7, Endothelin-converting enzyme 1 (ECE-1)(EC 3.4.24.71) ECE1 ENSG00000117298 [Source:UniProtKB/Swiss-Prot;Acc:P42892] 6.84 8.03 1.18 2.27 2.05E-06 4.41E-05 6.81E-08 8.46E-07 1.18 1 hsa-miR-27a, Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S)(Transcription factor CA150) TCERG1 ENSG00000113649 [Source:UniProtKB/Swiss-Prot;Acc:O14776] 6.77 7.96 1.18 2.27 1.54E-04 1.47E-03 5.08E-07 5.05E-06 1.52 2 hsa-miR-24,hsa-miR-7, Eukaryotic translation initiation factor 2 subunit 3 (Eukaryotic translation initiation factor 2 subunit gamma)(eIF-2-gamma) EIF2S3 ENSG00000130741 [Source:UniProtKB/Swiss-Prot;Acc:P41091] 8.92 10.10 1.18 2.27 6.94E-04 5.07E-03 8.23E-06 6.20E-05 1.21 3 hsa-miR-132,hsa-miR-221,hsa-miR-7, Non-histone chromosomal protein HMG-17 (High-mobility group nucleosome-binding domain-containing protein 2) HMGN2 ENSG00000198830 [Source:UniProtKB/Swiss-Prot;Acc:P05204] 8.98 10.17 1.19 2.27 2.85E-04 2.44E-03 3.61E-07 3.70E-06 1.19 1 hsa-miR-132, Coiled-coil domain-containing protein 117 [Source:UniProtKB/Swiss- CCDC117 ENSG00000159873 Prot;Acc:Q8IWD4] 6.07 7.25 1.19 2.27 6.69E-07 1.75E-05 2.99E-10 6.75E-09 1.32 3 hsa-miR-132,hsa-miR-200b,hsa-miR-24, GTPase NRas Precursor (Transforming protein N-Ras) NRAS ENSG00000213281 [Source:UniProtKB/Swiss-Prot;Acc:P01111] 7.62 8.81 1.19 2.28 2.52E-04 2.20E-03 2.89E-06 2.41E-05 1.30 2 hsa-let-7f,hsa-miR-7, SRC-like-adapter (Src-like-adapter protein 1)(hSLAP) SLA ENSG00000155926 [Source:UniProtKB/Swiss-Prot;Acc:Q13239] 7.38 8.57 1.19 2.28 2.66E-04 2.30E-03 1.46E-06 1.30E-05 1.62 1 hsa-miR-155, COP9 signalosome complex subunit 3 (Signalosome subunit 3)(SGN3)(JAB1-containing signalosome subunit 3) COPS3 ENSG00000141030 [Source:UniProtKB/Swiss-Prot;Acc:Q9UNS2] 6.42 7.61 1.19 2.28 2.08E-05 2.87E-04 1.93E-07 2.14E-06 1.50 1 hsa-miR-155, TRAF and TNF receptor-associated protein (ETS1-associated protein 2)(ETS1-associated protein II)(EAPII) TTRAP ENSG00000111802 [Source:UniProtKB/Swiss-Prot;Acc:O95551] 7.04 8.23 1.19 2.28 4.80E-04 3.74E-03 8.94E-06 6.68E-05 1.27 1 hsa-miR-21, SNX4 ENSG00000114520 Sorting nexin-4 [Source:UniProtKB/Swiss-Prot;Acc:O95219] 6.52 7.71 1.19 2.28 7.59E-05 8.25E-04 1.72E-09 3.13E-08 1.82 2 hsa-miR-218,hsa-miR-222, AP-3 complex subunit mu-1 (Adapter-related protein complex 3 mu-1 subunit)(AP-3 adapter complex mu3A subunit)(Mu-adaptin 3A)(Mu3A- AP3M1 ENSG00000185009 adaptin) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2T2] 6.43 7.63 1.19 2.28 2.03E-04 1.85E-03 1.63E-07 1.84E-06 1.63 3 hsa-miR-218,hsa-miR-221,hsa-miR-7, Ras-related protein Rab-8A (Oncogene c-mel) RAB8A ENSG00000167461 [Source:UniProtKB/Swiss-Prot;Acc:P61006] 6.98 8.17 1.19 2.28 6.24E-04 4.64E-03 1.10E-06 1.01E-05 1.79 3 hsa-miR-132,hsa-miR-218,hsa-miR-24, Cohesin subunit SA-1 (Stromal antigen 1)(SCC3 homolog 1) STAG1 ENSG00000118007 [Source:UniProtKB/Swiss-Prot;Acc:Q8WVM7] 6.12 7.32 1.19 2.29 1.41E-03 8.96E-03 3.54E-04 1.82E-03 1.19 1 hsa-miR-27a, T-lymphocyte activation antigen CD80 Precursor (Activation B7-1 antigen)(CTLA-4 counter-receptor B7.1)(B7)(BB1)(CD80 antigen) CD80 ENSG00000121594 [Source:UniProtKB/Swiss-Prot;Acc:P33681] 5.64 6.83 1.19 2.29 2.13E-08 1.09E-06 2.25E-10 5.29E-09 1.70 1 hsa-miR-21, F-actin-capping protein subunit alpha-1 (CapZ alpha-1) CAPZA1 ENSG00000116489 [Source:UniProtKB/Swiss-Prot;Acc:P52907] 7.94 9.13 1.19 2.29 5.86E-04 4.41E-03 2.32E-06 1.98E-05 1.55 1 hsa-miR-7, Ankyrin repeat and LEM domain-containing protein 2 ANKLE2 ENSG00000176915 [Source:UniProtKB/Swiss-Prot;Acc:Q86XL3] 6.74 7.94 1.20 2.29 1.99E-06 4.33E-05 3.53E-09 5.91E-08 1.20 1 hsa-miR-221, General transcription factor IIE subunit 1 (Transcription initiation factor IIE subunit alpha)(TFIIE-alpha)(General transcription factor IIE GTF2E1 ENSG00000153767 56 kDa subunit) [Source:UniProtKB/Swiss-Prot;Acc:P29083] 5.17 6.37 1.20 2.29 1.38E-05 2.05E-04 8.14E-09 1.25E-07 1.43 1 hsa-miR-222, F-actin-capping protein subunit alpha-2 (CapZ alpha-2) CAPZA2 ENSG00000198898 [Source:UniProtKB/Swiss-Prot;Acc:P47755] 7.06 8.26 1.20 2.29 1.08E-03 7.21E-03 3.11E-05 2.05E-04 1.48 1 hsa-miR-218, Fragile X mental retardation syndrome-related protein 1 (hFXR1p) FXR1 ENSG00000114416 [Source:UniProtKB/Swiss-Prot;Acc:P51114] 6.60 7.80 1.20 2.29 8.16E-04 5.78E-03 3.53E-04 1.82E-03 1.20 5 hsa-miR-132,hsa-miR-155,hsa-miR-19a,hsa-miR-200b,hsa-miR-7, WD repeat-containing protein 40A (Centrosome-related protein TCC52)(Testis cancer centrosome-related protein) WDR40A ENSG00000198876 [Source:UniProtKB/Swiss-Prot;Acc:Q5T6F0] 6.20 7.40 1.20 2.29 1.24E-06 2.92E-05 1.30E-10 3.26E-09 1.58 4 hsa-miR-218,hsa-miR-222,hsa-miR-27b,hsa-miR-7, CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1)(Multiple asters homolog 1)(hOrbit1) [Source:UniProtKB/Swiss- CLASP1 ENSG00000074054 Prot;Acc:Q7Z460] 6.42 7.62 1.20 2.29 1.21E-04 1.20E-03 4.85E-05 3.07E-04 1.20 1 hsa-miR-200b, Exportin-7 (Exp7)(Ran-binding protein 16) [Source:UniProtKB/Swiss- XPO7 ENSG00000130227 Prot;Acc:Q9UIA9] 5.74 6.94 1.20 2.30 7.85E-05 8.46E-04 1.03E-05 7.59E-05 1.20 1 hsa-miR-7, Drebrin (Developmentally-regulated brain protein) DBN1 ENSG00000113758 [Source:UniProtKB/Swiss-Prot;Acc:Q16643] 6.30 7.51 1.20 2.30 1.72E-11 3.39E-09 1.27E-15 1.36E-13 1.29 2 hsa-miR-19a,hsa-miR-218, TATA-binding protein-associated factor 2N (RNA-binding protein TAF15 ENSG00000172660 56)(TAFII68)(TAF(II)68) [Source:UniProtKB/Swiss-Prot;Acc:Q92804] 6.76 7.96 1.20 2.30 8.65E-05 9.13E-04 2.33E-07 2.52E-06 1.29 1 hsa-miR-132, Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial Precursor (EC 2.8.3.5)(3-oxoacid-CoA transferase 1)(Somatic-type succinyl CoA:3-oxoacid CoA-transferase)(Scot-S) OXCT1 ENSG00000083720 [Source:UniProtKB/Swiss-Prot;Acc:P55809] 5.65 6.85 1.20 2.30 2.06E-05 2.86E-04 3.36E-07 3.48E-06 1.71 1 hsa-miR-155, Ran-binding protein 9 (RanBP9)(RanBP7)(Ran-binding protein M)(RanBPM)(BPM90)(BPM-L) [Source:UniProtKB/Swiss- RANBP9 ENSG00000010017 Prot;Acc:Q96S59] 6.55 7.75 1.20 2.30 1.26E-03 8.18E-03 1.56E-03 6.81E-03 1.20 1 hsa-miR-200b, ZNF706 ENSG00000120963 Zinc finger protein 706 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5V0] 6.73 7.93 1.21 2.31 2.56E-05 3.39E-04 6.46E-09 1.01E-07 1.71 3 hsa-miR-132,hsa-miR-155,hsa-miR-7, Proline-rich protein 3 (MHC class I region proline-rich protein PRR3 ENSG00000204576 CAT56) [Source:UniProtKB/Swiss-Prot;Acc:P79522] 5.79 7.00 1.21 2.31 3.62E-06 7.02E-05 4.83E-10 1.03E-08 1.65 4 hsa-miR-200b,hsa-miR-27a,hsa-miR-29b,hsa-miR-7, DnaJ homolog subfamily C member 18 [Source:UniProtKB/Swiss- DNAJC18 ENSG00000170464 Prot;Acc:Q9H819] 5.99 7.19 1.21 2.31 7.04E-11 1.05E-08 3.98E-14 2.77E-12 1.21 2 hsa-miR-155,hsa-miR-424, Folliculin-interacting protein 2 (FNIP1-like protein) FNIP2 ENSG00000052795 [Source:UniProtKB/Swiss-Prot;Acc:Q9P278] 5.56 6.77 1.21 2.31 3.64E-05 4.50E-04 4.14E-07 4.20E-06 1.46 4 hsa-miR-155,hsa-miR-21,hsa-miR-221,hsa-miR-7, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta Precursor (EC 2.7.8.17)(GlcNAc-1-phosphotransferase subunits alpha/beta)(Stealth protein GNPTAB)(UDP-N-acetylglucosamine-1- phosphotransferase subunits alpha/beta) [Contains N- GNPTAB ENSG00000111670 acetylglucosamine-1 6.70 7.90 1.21 2.31 3.89E-04 3.15E-03 5.11E-04 2.53E-03 1.21 1 hsa-miR-7, Dual specificity protein phosphatase 14 (EC 3.1.3.48)(EC 3.1.3.16)(Mitogen-activated protein kinase phosphatase 6)(MAP kinase phosphatase 6)(MKP-6)(MKP-1-like protein tyrosine DUSP14 ENSG00000161326 phosphatase)(MKP-L) [Source:UniProtKB/Swiss-Prot;Acc:O95147] 5.45 6.65 1.21 2.31 1.15E-08 6.54E-07 1.11E-09 2.12E-08 1.54 1 hsa-miR-155, Uroplakin-1a (UP1a)(Uroplakin Ia)(UPIa)(UPKa)(Tetraspanin- UPK1A ENSG00000105668 21)(Tspan-21) [Source:UniProtKB/Swiss-Prot;Acc:O00322] 5.17 6.38 1.21 2.31 2.15E-06 4.57E-05 1.25E-05 9.05E-05 1.21 1 hsa-miR-24, FAM91A1 ENSG00000176853 Protein FAM91A1 [Source:UniProtKB/Swiss-Prot;Acc:Q658Y4] 5.99 7.20 1.21 2.31 5.37E-05 6.20E-04 1.88E-06 1.64E-05 1.35 3 hsa-miR-132,hsa-miR-155,hsa-miR-365, 28S ribosomal protein S12, mitochondrial Precursor (S12mt)(MRP- MRPS12 ENSG00000128626 S12)(MT-RPS12) [Source:UniProtKB/Swiss-Prot;Acc:O15235] 5.28 6.49 1.21 2.31 3.03E-06 6.09E-05 9.20E-10 1.80E-08 1.86 1 hsa-miR-7, Phosphotriesterase-related protein (Parathion hydrolase-related PTER ENSG00000165983 protein)(HPHRP) [Source:UniProtKB/Swiss-Prot;Acc:Q96BW5] 6.98 8.19 1.21 2.32 9.34E-06 1.49E-04 1.45E-07 1.66E-06 1.42 2 hsa-miR-365,hsa-miR-7, Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.16)(Hypoxia- inducible factor asparagine hydroxylase)(Factor inhibiting HIF-1)(FIH- HIF1AN ENSG00000166135 1) [Source:UniProtKB/Swiss-Prot;Acc:Q9NWT6] 5.56 6.78 1.21 2.32 5.71E-04 4.33E-03 1.71E-05 1.20E-04 1.28 3 hsa-let-7f,hsa-miR-135b,hsa-miR-24, Centrosomal protein of 170 kDa (Cep170)(KARP-1-binding protein)(KARP1-binding protein) [Source:UniProtKB/Swiss- CEP170 ENSG00000143702 Prot;Acc:Q5SW79] 5.79 7.01 1.21 2.32 4.65E-04 3.64E-03 2.95E-04 1.55E-03 1.21 1 hsa-miR-19b, Iron-responsive element-binding protein 2 (IRE-BP 2)(Iron regulatory IREB2 ENSG00000136381 protein 2)(IRP2) [Source:UniProtKB/Swiss-Prot;Acc:P48200] 6.60 7.82 1.21 2.32 4.73E-04 3.69E-03 2.13E-04 1.16E-03 1.21 2 hsa-miR-18a,hsa-miR-19a, Neuronal protein 3.1 (Protein p311) [Source:UniProtKB/Swiss- C5orf13 ENSG00000134986 Prot;Acc:Q16612] 5.97 7.19 1.22 2.32 3.40E-08 1.57E-06 6.30E-08 7.88E-07 1.22 6 hsa-miR-132,hsa-miR-200b,hsa-miR-24,hsa-miR-27b,hsa-miR-29b,hsa-miR-7, Transmembrane protein 14B [Source:UniProtKB/Swiss- TMEM14B ENSG00000137210 Prot;Acc:Q9NUH8] 7.64 8.86 1.22 2.32 1.40E-03 8.92E-03 5.10E-06 4.04E-05 1.58 1 hsa-miR-7, Protein phosphatase 1G (EC 3.1.3.16)(Protein phosphatase 2C isoform gamma)(PP2C-gamma)(Protein phosphatase magnesium- dependent 1 gamma)(Protein phosphatase 1C) PPM1G ENSG00000115241 [Source:UniProtKB/Swiss-Prot;Acc:O15355] 6.47 7.69 1.22 2.33 1.59E-05 2.31E-04 5.55E-11 1.54E-09 1.91 3 hsa-miR-132,hsa-miR-206,hsa-miR-24, Interleukin-18 receptor 1 Precursor (IL1 receptor-related protein)(IL- 1Rrp)(CD218 antigen-like family member A)(CDw218a)(CD218a IL18R1 ENSG00000115604 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q13478] 5.90 7.11 1.22 2.33 4.08E-04 3.27E-03 3.20E-05 2.10E-04 1.32 2 hsa-miR-155,hsa-miR-424, Carbonic anhydrase 2 (EC 4.2.1.1)(Carbonic anhydrase II)(CA- II)(Carbonate dehydratase II)(Carbonic anhydrase C)(CAC) CA2 ENSG00000104267 [Source:UniProtKB/Swiss-Prot;Acc:P00918] 5.52 6.74 1.22 2.33 4.71E-05 5.57E-04 2.05E-05 1.41E-04 1.22 2 hsa-miR-218,hsa-miR-424, Craniofacial development protein 1 (Bucentaur) CFDP1 ENSG00000153774 [Source:UniProtKB/Swiss-Prot;Acc:Q9UEE9] 5.87 7.09 1.22 2.33 1.13E-04 1.14E-03 6.38E-05 3.92E-04 1.22 1 hsa-miR-27a, Mitochondrial folate transporter/carrier (Solute carrier family 25 SLC25A32 ENSG00000164933 member 32) [Source:UniProtKB/Swiss-Prot;Acc:Q9H2D1] 6.53 7.76 1.22 2.33 1.12E-04 1.13E-03 4.82E-10 1.03E-08 2.15 1 hsa-miR-130b, 6.8 kDa mitochondrial proteolipid [Source:UniProtKB/Swiss- C14orf2 ENSG00000156411 Prot;Acc:P56378] 7.42 8.65 1.22 2.33 4.35E-04 3.45E-03 2.84E-05 1.89E-04 1.60 1 hsa-miR-24, ATP synthase lipid-binding protein, mitochondrial Precursor (ATP synthase proteolipid P3)(ATPase protein 9)(ATPase subunit c) ATP5G3 ENSG00000154518 [Source:UniProtKB/Swiss-Prot;Acc:P48201] 8.18 9.40 1.22 2.34 5.69E-05 6.49E-04 8.44E-08 1.02E-06 1.75 3 hsa-miR-21,hsa-miR-27a,hsa-miR-7, Transmembrane protein C9orf91 [Source:UniProtKB/Swiss- C9orf91 ENSG00000157693 Prot;Acc:Q5VZI3] 5.97 7.19 1.22 2.34 1.69E-07 5.79E-06 9.97E-10 1.93E-08 1.22 2 hsa-miR-27a,hsa-miR-7, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3)(NF-kappa-B-activating protein 1) MAP3K7IP3 ENSG00000157625 [Source:UniProtKB/Swiss-Prot;Acc:Q8N5C8] 6.37 7.59 1.22 2.34 1.44E-04 1.39E-03 1.87E-05 1.30E-04 1.22 3 hsa-miR-200b,hsa-miR-222,hsa-miR-27a,

MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3)(MAPKAP kinase 3)(MAPKAPK-3)(EC 2.7.11.1)(Chromosome 3p MAPKAPK3 ENSG00000114738 kinase)(3pK) [Source:UniProtKB/Swiss-Prot;Acc:Q16644] 6.77 7.99 1.23 2.34 1.07E-06 2.58E-05 6.78E-11 1.84E-09 1.66 2 hsa-miR-27a,hsa-miR-7, Claudin domain-containing protein 1 (Membrane protein GENX-3745) CLDND1 ENSG00000080822 [Source:UniProtKB/Swiss-Prot;Acc:Q9NY35] 7.46 8.69 1.23 2.34 1.24E-04 1.23E-03 2.63E-07 2.80E-06 1.42 1 hsa-miR-221, Probable ribonuclease ZC3H12D (EC 3.1.-.-)(Zinc finger CCCH domain-containing protein 12D)(MCP-induced protein 4)(p34) ZC3H12D ENSG00000178199 [Source:UniProtKB/Swiss-Prot;Acc:A2A288] 6.45 7.68 1.23 2.34 1.57E-06 3.56E-05 2.10E-07 2.30E-06 1.23 1 hsa-miR-7, Signaling threshold-regulating transmembrane adapter 1 Precursor (Suppression-inducing transmembrane adapter 1)(SHP2-interacting transmembrane adapter protein)(gp30/40) [Source:UniProtKB/Swiss- SIT1 ENSG00000137078 Prot;Acc:Q9Y3P8] 6.87 8.10 1.23 2.34 1.09E-03 7.29E-03 7.55E-04 3.58E-03 1.23 1 hsa-miR-132, KDEL motif-containing protein 1 Precursor (Endoplasmic reticulum resident protein 58)(ER protein 58) [Source:UniProtKB/Swiss- KDELC1 ENSG00000134901 Prot;Acc:Q6UW63] 4.76 5.99 1.23 2.35 3.59E-08 1.63E-06 4.88E-11 1.38E-09 1.69 1 hsa-miR-200b, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G)(EC 3.1.3.16)(Protein phosphatase 1C catalytic subunit) PPP1CC ENSG00000186298 [Source:UniProtKB/Swiss-Prot;Acc:P36873] 9.17 10.40 1.23 2.35 7.49E-06 1.25E-04 1.75E-09 3.18E-08 1.34 4 hsa-miR-135b,hsa-miR-21,hsa-miR-218,hsa-miR-27a, GDP-mannose 4,6 dehydratase (EC 4.2.1.47)(GDP-D-mannose GMDS ENSG00000112699 dehydratase)(GMD) [Source:UniProtKB/Swiss-Prot;Acc:O60547] 6.34 7.57 1.23 2.35 4.47E-06 8.28E-05 5.27E-10 1.11E-08 1.62 1 hsa-miR-221, Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Precursor (Succinate dehydrogenase complex subunit C)(Integral membrane protein CII-3)(QPs-1)(QPs1)(Succinate-ubiquinone oxidoreductase cytochrome B large subunit)(CYBL) SDHC ENSG00000143252 [Source:UniProtKB/Swis 6.59 7.82 1.23 2.35 4.32E-04 3.43E-03 1.05E-07 1.25E-06 1.85 2 hsa-miR-155,hsa-miR-365, Suppressor of tumorigenicity protein 7 (Protein HELG) ST7 ENSG00000004866 [Source:UniProtKB/Swiss-Prot;Acc:Q9NRC1] 5.73 6.97 1.23 2.35 1.44E-06 3.33E-05 2.00E-08 2.80E-07 1.23 1 hsa-miR-19a, NMDA receptor-regulated protein 1 (N-terminal acetyltransferase)(Protein tubedown-1)(Tbdn100)(Gastric cancer NARG1 ENSG00000164134 antigen Ga19) [Source:UniProtKB/Swiss-Prot;Acc:Q9BXJ9] 6.14 7.37 1.23 2.35 8.60E-04 6.04E-03 4.73E-07 4.74E-06 1.96 3 hsa-miR-155,hsa-miR-218,hsa-miR-27b, Fatty acid desaturase 2 (EC 1.14.19.-)(Delta(6) fatty acid desaturase)(Delta(6) desaturase)(D6D) [Source:UniProtKB/Swiss- FADS2 ENSG00000134824 Prot;Acc:O95864] 5.20 6.43 1.23 2.35 2.66E-06 5.47E-05 7.88E-11 2.08E-09 1.84 1 hsa-miR-7, Transportin-3 (Transportin-SR)(TRN-SR)(Importin-12)(Imp12) TNPO3 ENSG00000064419 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5L0] 6.38 7.61 1.24 2.35 8.94E-05 9.38E-04 7.57E-06 5.74E-05 1.24 2 hsa-miR-210,hsa-miR-27a, Ataxin-2-like protein (Ataxin-2 domain protein)(Ataxin-2-related ATXN2L ENSG00000168488 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q8WWM7] 6.62 7.86 1.24 2.36 4.14E-06 7.76E-05 3.72E-08 4.87E-07 1.24 1 hsa-miR-18a, Uncharacterized protein C12orf32 [Source:UniProtKB/Swiss- C12orf32 ENSG00000171792 Prot;Acc:Q9BSD3] 6.69 7.93 1.24 2.36 9.79E-06 1.55E-04 4.07E-07 4.13E-06 1.24 1 hsa-miR-18a, Methylosome subunit pICln (Chloride conductance regulatory protein ICln)(I(Cln))(Chloride channel, nucleotide sensitive 1A)(Chloride ion current inducer protein)(ClCI)(Reticulocyte pICln) CLNS1A ENSG00000074201 [Source:UniProtKB/Swiss-Prot;Acc:P54105] 7.12 8.36 1.24 2.36 3.99E-05 4.84E-04 1.26E-07 1.47E-06 1.49 2 hsa-miR-21,hsa-miR-7, Proteolipid protein 2 (Intestinal membrane A4 protein)(Differentiation- PLP2 ENSG00000102007 dependent protein A4) [Source:UniProtKB/Swiss-Prot;Acc:Q04941] 8.33 9.57 1.24 2.37 4.54E-05 5.41E-04 1.16E-05 8.46E-05 1.24 1 hsa-miR-7, Lin-9 homolog (huLin-9)(hLin-9)(Beta subunit-associated regulator of apoptosis)(Type I interferon receptor beta chain-associated protein)(TUDOR gene similar protein)(pRB-associated protein) LIN9 ENSG00000183814 [Source:UniProtKB/Swiss-Prot;Acc:Q5TKA1] 5.15 6.40 1.24 2.37 1.79E-07 6.07E-06 7.99E-11 2.11E-09 1.28 4 hsa-miR-132,hsa-miR-155,hsa-miR-19a,hsa-miR-7, Myelin protein zero-like protein 1 Precursor (Protein zero-related) MPZL1 ENSG00000197965 [Source:UniProtKB/Swiss-Prot;Acc:O95297] 5.68 6.92 1.25 2.38 3.04E-08 1.44E-06 2.58E-11 7.81E-10 1.52 2 hsa-miR-18a,hsa-miR-221, LPIN2 ENSG00000101577 Lipin-2 [Source:UniProtKB/Swiss-Prot;Acc:Q92539] 6.79 8.04 1.25 2.38 3.13E-06 6.27E-05 9.48E-06 7.05E-05 1.25 4 hsa-miR-18a,hsa-miR-200b,hsa-miR-218,hsa-miR-27a,

F-box/WD repeat-containing protein 11 (F-box/WD repeat-containing protein 1B)(F-box and WD repeats protein beta-TrCP2)(Homologous FBXW11 ENSG00000072803 to Slimb protein)(HOS) [Source:UniProtKB/Swiss-Prot;Acc:Q9UKB1] 7.11 8.36 1.25 2.38 8.97E-05 9.42E-04 3.13E-06 2.59E-05 1.25 4 hsa-miR-132,hsa-miR-19a,hsa-miR-200b,hsa-miR-218, ARMCX6 ENSG00000198960 Protein ARMCX6 [Source:UniProtKB/Swiss-Prot;Acc:Q7L4S7] 6.36 7.61 1.25 2.38 2.25E-05 3.05E-04 4.96E-07 4.95E-06 1.26 1 hsa-miR-7, Transcription termination factor 1 (TTF-1)(TTF-I)(RNA polymerase I TTF1 ENSG00000125482 termination factor) [Source:UniProtKB/Swiss-Prot;Acc:Q15361] 5.26 6.51 1.25 2.38 2.17E-04 1.95E-03 5.54E-07 5.46E-06 1.61 1 hsa-miR-155, PCI domain-containing protein 2 (CSN12-like protein) PCID2 ENSG00000126226 [Source:UniProtKB/Swiss-Prot;Acc:Q5JVF3] 6.01 7.26 1.25 2.38 4.40E-04 3.48E-03 1.65E-05 1.16E-04 1.50 1 hsa-miR-7, Sideroflexin-4 (Breast cancer resistance marker 1) SFXN4 ENSG00000183605 [Source:UniProtKB/Swiss-Prot;Acc:Q6P4A7] 5.81 7.07 1.25 2.38 1.02E-05 1.61E-04 5.64E-10 1.18E-08 1.79 1 hsa-miR-27a, Sorting nexin-6 (TRAF4-associated factor 2) SNX6 ENSG00000129515 [Source:UniProtKB/Swiss-Prot;Acc:Q9UNH7] 6.71 7.96 1.25 2.38 1.28E-03 8.31E-03 2.39E-04 1.28E-03 1.25 1 hsa-miR-18a, Myelin expression factor 2 (MyEF-2)(MST156) MYEF2 ENSG00000104177 [Source:UniProtKB/Swiss-Prot;Acc:Q9P2K5] 5.35 6.60 1.25 2.38 7.63E-05 8.28E-04 9.45E-05 5.56E-04 1.25 1 hsa-miR-135b, Chloride channel protein 3 (ClC-3) [Source:UniProtKB/Swiss- CLCN3 ENSG00000109572 Prot;Acc:P51790] 5.93 7.18 1.25 2.38 4.42E-04 3.49E-03 1.58E-04 8.83E-04 1.25 2 hsa-miR-155,hsa-miR-24, Serine hydroxymethyltransferase, cytosolic (SHMT)(Serine methylase)(EC 2.1.2.1)(Glycine hydroxymethyltransferase) SHMT1 ENSG00000176974 [Source:UniProtKB/Swiss-Prot;Acc:P34896] 5.52 6.78 1.26 2.39 2.08E-07 6.91E-06 5.77E-13 2.77E-11 1.83 1 hsa-miR-218, Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1)(Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase)(Hemin-sensitive initiation factor 2-alpha kinase)(Heme- EIF2AK1 ENSG00000086232 regulated inhibitor)(Heme-controlled repressor)(HCR) [Source:Uni 6.62 7.87 1.26 2.39 2.00E-04 1.83E-03 5.55E-06 4.34E-05 1.32 1 hsa-miR-7, Zinc finger protein 367 (C2H2 zinc finger protein ZFF29) ZNF367 ENSG00000165244 [Source:UniProtKB/Swiss-Prot;Acc:Q7RTV3] 5.66 6.92 1.26 2.39 2.05E-07 6.80E-06 3.10E-14 2.21E-12 1.75 4 hsa-miR-18a,hsa-miR-21,hsa-miR-7,hsa-miR-93, Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta)(HP1 beta)(Modifier 1 protein)(M31)(Heterochromatin protein p25)(HP1Hsbeta)(p25beta) [Source:UniProtKB/Swiss- CBX1 ENSG00000108468 Prot;Acc:P83916] 6.05 7.30 1.26 2.39 2.00E-06 4.34E-05 3.43E-09 5.78E-08 1.40 3 hsa-miR-19a,hsa-miR-218,hsa-miR-27a, Ubiquitin-conjugating enzyme E2 Z (EC 6.3.2.19)(Ubiquitin-protein ligase Z)(Ubiquitin carrier protein Z)(Uba6-specific E2 conjugating UBE2Z ENSG00000159202 enzyme 1)(Use1) [Source:UniProtKB/Swiss-Prot;Acc:Q9H832] 7.39 8.65 1.26 2.39 3.56E-05 4.41E-04 9.36E-08 1.12E-06 1.26 2 hsa-miR-18a,hsa-miR-7, Glycogen [starch] synthase, muscle (EC 2.4.1.11) GYS1 ENSG00000104812 [Source:UniProtKB/Swiss-Prot;Acc:P13807] 5.81 7.07 1.26 2.40 2.13E-05 2.92E-04 6.07E-08 7.62E-07 1.26 1 hsa-miR-7, Probable ATP-dependent RNA helicase DHX40 (EC 3.6.1.-)(DEAH box protein 40)(Protein PAD) [Source:UniProtKB/Swiss- DHX40 ENSG00000108406 Prot;Acc:Q8IX18] 6.19 7.45 1.26 2.40 2.21E-04 1.98E-03 1.57E-04 8.78E-04 1.26 2 hsa-miR-155,hsa-miR-19a, Ras-related protein Rab-21 [Source:UniProtKB/Swiss- RAB21 ENSG00000080371 Prot;Acc:Q9UL25] 6.83 8.09 1.26 2.40 3.85E-04 3.12E-03 2.32E-05 1.58E-04 1.26 2 hsa-miR-19a,hsa-miR-200b, Transmembrane protein 216 [Source:UniProtKB/Swiss- TMEM216 ENSG00000187049 Prot;Acc:Q9P0N5] 5.98 7.25 1.27 2.40 8.23E-05 8.79E-04 2.84E-06 2.37E-05 1.41 1 hsa-miR-24, Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein)(Membrane component, chromosome 17, surface marker NBR1 ENSG00000188554 2)(1A1-3B) [Source:UniProtKB/Swiss-Prot;Acc:Q14596] 5.67 6.94 1.27 2.41 1.18E-04 1.18E-03 4.14E-05 2.66E-04 1.27 1 hsa-miR-200b, 39S ribosomal protein L48, mitochondrial Precursor (L48mt)(MRP- MRPL48 ENSG00000175581 L48) [Source:UniProtKB/Swiss-Prot;Acc:Q96GC5] 5.91 7.18 1.27 2.41 3.06E-04 2.58E-03 5.44E-06 4.27E-05 1.58 1 hsa-miR-7, Myotubularin-related protein 4 (EC 3.1.3.48)(FYVE domain-containing dual specificity protein phosphatase 2)(FYVE-DSP2)(Zinc finger FYVE domain-containing protein 11) [Source:UniProtKB/Swiss- MTMR4 ENSG00000108389 Prot;Acc:Q9NYA4] 6.39 7.66 1.27 2.41 6.81E-07 1.78E-05 1.58E-09 2.92E-08 1.32 1 hsa-miR-424, Src substrate cortactin (Amplaxin)(Oncogene EMS1) CTTN ENSG00000085733 [Source:UniProtKB/Swiss-Prot;Acc:Q14247] 5.86 7.13 1.27 2.41 3.47E-10 3.77E-08 5.41E-16 6.41E-14 1.43 2 hsa-miR-210,hsa-miR-222, Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor)(Type 2 InsP3 receptor)(IP3 receptor isoform ITPR2 ENSG00000123104 2)(InsP3R2) [Source:UniProtKB/Swiss-Prot;Acc:Q14571] 6.04 7.31 1.27 2.41 5.33E-04 4.08E-03 6.61E-05 4.05E-04 1.27 1 hsa-miR-21, Integrin alpha-2 Precursor (Platelet membrane glycoprotein Ia)(GPIa)(Collagen receptor)(VLA-2 alpha chain)(CD49 antigen-like family member B)(CD49b antigen) [Source:UniProtKB/Swiss- ITGA2 ENSG00000164171 Prot;Acc:P17301] 5.23 6.50 1.27 2.41 5.20E-06 9.33E-05 3.01E-07 3.16E-06 1.27 4 hsa-miR-19a,hsa-miR-200b,hsa-miR-24,hsa-miR-27a, Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial Precursor (EC 3.4.21.92)(Endopeptidase Clp) CLPP ENSG00000125656 [Source:UniProtKB/Swiss-Prot;Acc:Q16740] 6.86 8.13 1.27 2.41 1.54E-05 2.25E-04 8.35E-10 1.67E-08 1.77 1 hsa-miR-27a, Ubiquitin-conjugating enzyme E2 N (EC 6.3.2.19)(Ubiquitin-protein ligase N)(Ubiquitin carrier protein N)(Ubc13)(Bendless-like ubiquitin- UBE2N ENSG00000177889 conjugating enzyme) [Source:UniProtKB/Swiss-Prot;Acc:P61088] 7.15 8.43 1.27 2.42 2.40E-04 2.12E-03 1.55E-06 1.38E-05 1.85 2 hsa-miR-27a,hsa-miR-7, Protein salvador homolog 1 (45 kDa WW domain protein)(hWW45) SAV1 ENSG00000151748 [Source:UniProtKB/Swiss-Prot;Acc:Q9H4B6] 6.26 7.53 1.28 2.42 3.89E-04 3.15E-03 2.30E-05 1.56E-04 1.35 3 hsa-miR-21,hsa-miR-27a,hsa-miR-7, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta)(EC 3.1.3.16) [Source:UniProtKB/Swiss- PPP2CB ENSG00000104695 Prot;Acc:P62714] 6.11 7.38 1.28 2.42 1.52E-04 1.46E-03 5.81E-08 7.32E-07 1.59 3 hsa-miR-132,hsa-miR-155,hsa-miR-218,

DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1)(DNA-directed RNA polymerase II subunit E)(RPB5)(DNA-directed RNA polymerase II 23 POLR2E ENSG00000099817 kDa polypeptide)(XAP4) [Source:UniProtKB/Swiss-Prot;Acc:P19388] 6.79 8.07 1.28 2.42 2.34E-05 3.16E-04 3.66E-09 6.11E-08 1.62 1 hsa-miR-7, Transcriptional repressor NF-X1 (EC 6.3.2.-)(Nuclear transcription factor, X box-binding protein 1) [Source:UniProtKB/Swiss- NFX1 ENSG00000086102 Prot;Acc:Q12986] 6.61 7.89 1.28 2.42 2.70E-05 3.53E-04 1.01E-06 9.33E-06 1.28 1 hsa-miR-27a, Uncharacterized protein C11orf57 [Source:UniProtKB/Swiss- C11orf57 ENSG00000150776 Prot;Acc:Q6ZUT1] 5.76 7.03 1.28 2.42 1.59E-04 1.51E-03 6.68E-06 5.13E-05 1.41 4 hsa-let-7f,hsa-miR-19a,hsa-miR-218,hsa-miR-7, Zinc finger protein 664 (Zinc finger protein from organ of Corti) ZNF664 ENSG00000179195 [Source:UniProtKB/Swiss-Prot;Acc:Q8N3J9] 5.73 7.01 1.28 2.43 3.78E-04 3.07E-03 3.70E-05 2.39E-04 1.40 2 hsa-miR-155,hsa-miR-365, Actin, aortic smooth muscle (Alpha-actin-2)(Cell growth-inhibiting ACTA2 ENSG00000107796 gene 46 protein) [Source:UniProtKB/Swiss-Prot;Acc:P62736] 5.72 7.00 1.28 2.43 9.04E-08 3.45E-06 1.00E-11 3.41E-10 1.92 1 hsa-miR-27a, Aryl hydrocarbon receptor nuclear translocator (ARNT protein)(Class E basic helix-loop-helix protein 2)(bHLHe2)(Dioxin receptor, nuclear translocator)(Hypoxia-inducible factor 1 beta)(HIF-1 beta) ARNT ENSG00000143437 [Source:UniProtKB/Swiss-Prot;Acc:P27540] 5.87 7.15 1.28 2.43 2.70E-05 3.53E-04 1.60E-06 1.41E-05 1.28 3 hsa-miR-18a,hsa-miR-222,hsa-miR-7, Probable G-protein coupled receptor 125 Precursor GPR125 ENSG00000152990 [Source:UniProtKB/Swiss-Prot;Acc:Q8IWK6] 4.79 6.07 1.28 2.43 6.46E-07 1.71E-05 1.27E-11 4.19E-10 1.83 1 hsa-miR-27b, Tubulin polyglutamylase complex subunit 2 (PGs2) C18orf10 ENSG00000134779 [Source:UniProtKB/Swiss-Prot;Acc:Q68CL5] 6.34 7.62 1.28 2.43 1.17E-04 1.17E-03 7.69E-08 9.42E-07 1.69 2 hsa-miR-155,hsa-miR-7, GRAM domain-containing protein 3 (HCV NS3-transactivated protein GRAMD3 ENSG00000155324 2) [Source:UniProtKB/Swiss-Prot;Acc:Q96HH9] 5.51 6.79 1.28 2.43 1.30E-04 1.28E-03 2.44E-06 2.07E-05 1.31 2 hsa-miR-21,hsa-miR-363, Core-binding factor subunit beta (CBF-beta)(Polyomavirus enhancer- binding protein 2 beta subunit)(PEBP2-beta)(PEA2-beta)(SL3-3 enhancer factor 1 subunit beta)(SL3/AKV core-binding factor beta hsa-miR-130b,hsa-miR-155,hsa-miR-19b,hsa-miR-222,hsa-miR-27a,hsa-miR-365,hsa- CBFB ENSG00000067955 subunit) [Source:UniProtKB/Swiss-Prot;Acc:Q13951] 7.55 8.83 1.28 2.43 3.93E-05 4.78E-04 2.49E-09 4.35E-08 1.59 7 miR-7,

HLF ENSG00000108924 Hepatic leukemia factor [Source:UniProtKB/Swiss-Prot;Acc:Q16534] 4.97 6.25 1.28 2.43 1.50E-06 3.44E-05 6.06E-09 9.57E-08 1.28 3 hsa-miR-19a,hsa-miR-218,hsa-miR-7, Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-)(Felix-ina) ERMP1 ENSG00000099219 [Source:UniProtKB/Swiss-Prot;Acc:Q7Z2K6] 5.93 7.21 1.28 2.43 2.52E-04 2.20E-03 2.28E-04 1.23E-03 1.28 2 hsa-miR-155,hsa-miR-221, tRNA-specific adenosine deaminase 2 (EC 3.5.4.-)(tRNA-specific adenosine-34 deaminase subunit ADAT2)(Deaminase domain- ADAT2 ENSG00000189007 containing protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q7Z6V5] 6.63 7.91 1.29 2.44 4.70E-06 8.60E-05 2.95E-09 5.07E-08 1.65 4 hsa-miR-155,hsa-miR-18a,hsa-miR-21,hsa-miR-7, Zinc transporter ZIP1 (Zrt- and Irt-like protein 1)(ZIP- 1)(hZIP1)(Solute carrier family 39 member 1)(Zinc-iron-regulated SLC39A1 ENSG00000143570 transporter-like) [Source:UniProtKB/Swiss-Prot;Acc:Q9NY26] 6.45 7.74 1.29 2.44 2.36E-09 1.77E-07 9.30E-15 7.69E-13 1.43 2 hsa-miR-218,hsa-miR-24, ADP-ribosylation factor-like protein 8B (ADP-ribosylation factor-like protein 10C)(Novel small G protein indispensable for equal chromosome segregation 1) [Source:UniProtKB/Swiss- ARL8B ENSG00000134108 Prot;Acc:Q9NVJ2] 7.60 8.89 1.29 2.44 5.47E-05 6.30E-04 4.16E-08 5.39E-07 1.41 3 hsa-miR-155,hsa-miR-200b,hsa-miR-7, TXLNA ENSG00000084652 Alpha-taxilin [Source:UniProtKB/Swiss-Prot;Acc:P40222] 6.53 7.82 1.29 2.45 1.92E-08 1.00E-06 2.84E-14 2.05E-12 1.57 4 hsa-miR-106b,hsa-miR-19a,hsa-miR-221,hsa-miR-7, Ras-related protein R-Ras2 Precursor (Ras-like protein TC21)(Teratocarcinoma oncogene) [Source:UniProtKB/Swiss- RRAS2 ENSG00000133818 Prot;Acc:P62070] 6.24 7.53 1.29 2.45 7.91E-05 8.51E-04 2.88E-05 1.91E-04 1.31 1 hsa-miR-7, Serine/threonine-protein kinase MST4 (EC 2.7.11.1)(Mammalian STE20-like protein kinase 4)(STE20-like kinase MST4)(MST- 4)(Serine/threonine-protein kinase MASK)(Mst3 and SOK1-related RP6-213H19.1ENSG00000134602 kinase) [Source:UniProtKB/Swiss-Prot;Acc:Q9P289] 8.10 9.39 1.29 2.45 2.43E-05 3.25E-04 2.66E-07 2.83E-06 1.29 1 hsa-miR-19a, ATP-citrate synthase (EC 2.3.3.8)(ATP-citrate (pro-S-)-lyase)(Citrate ACLY ENSG00000131473 cleavage enzyme) [Source:UniProtKB/Swiss-Prot;Acc:P53396] 6.94 8.23 1.29 2.45 2.90E-05 3.74E-04 4.58E-12 1.70E-10 2.26 2 hsa-miR-27a,hsa-miR-7, Ribonuclease 4 Precursor (RNase 4)(EC 3.1.27.-) RNASE4 ENSG00000181784 [Source:UniProtKB/Swiss-Prot;Acc:P34096] 3.46 4.76 1.29 2.45 3.42E-05 4.28E-04 4.00E-06 3.23E-05 1.29 1 hsa-miR-155, Nuclear receptor 2C2-associated protein (TR4 orphan receptor- associated 16 kDa protein) [Source:UniProtKB/Swiss- NR2C2AP ENSG00000184162 Prot;Acc:Q86WQ0] 5.69 6.99 1.29 2.45 3.46E-05 4.32E-04 3.42E-09 5.77E-08 1.97 1 hsa-miR-218, C-C chemokine receptor type 4 (C-C CKR-4)(CC-CKR-4)(CCR- 4)(CCR4)(K5-5)(CD194 antigen) [Source:UniProtKB/Swiss- CCR4 ENSG00000183813 Prot;Acc:P51679] 7.95 9.24 1.29 2.45 1.07E-04 1.09E-03 2.44E-05 1.65E-04 1.29 1 hsa-miR-24, Mitogen-activated protein kinase 1 (EC 2.7.11.24)(Extracellular signal- regulated kinase 2)(ERK-2)(Mitogen-activated protein kinase 2)(MAP kinase 2)(MAPK 2)(p42-MAPK)(ERT1) [Source:UniProtKB/Swiss- MAPK1 ENSG00000100030 Prot;Acc:P28482] 7.92 9.22 1.30 2.45 5.18E-04 3.99E-03 6.34E-05 3.89E-04 1.30 3 hsa-miR-132,hsa-miR-19a,hsa-miR-7, Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2)(Dynein intermediate chain 2, cytosolic)(DH IC- DYNC1I2 ENSG00000077380 2) [Source:UniProtKB/Swiss-Prot;Acc:Q13409] 6.75 8.04 1.30 2.46 3.58E-04 2.94E-03 5.18E-07 5.13E-06 1.68 1 hsa-miR-218,

Lysosome-associated membrane glycoprotein 3 Precursor (Lysosomal- associated membrane protein 3)(LAMP-3)(DC-lysosome-associated membrane glycoprotein)(DC LAMP)(Protein TSC403)(CD208 LAMP3 ENSG00000078081 antigen) [Source:UniProtKB/Swiss-Prot;Acc:Q9UQV4] 5.37 6.67 1.30 2.46 4.52E-07 1.27E-05 2.46E-10 5.70E-09 1.43 1 hsa-miR-18a, Nuclear receptor coactivator 3 (NCoA-3)(EC 2.3.1.48)(Thyroid hormone receptor activator molecule 1)(TRAM-1)(ACTR)(Receptor- associated coactivator 3)(RAC-3)(Amplified in breast cancer-1 protein)(AIB-1)(Steroid receptor coactivator protein 3)(SRC-3)(CBP- NCOA3 ENSG00000124151 int 7.55 8.84 1.30 2.46 7.97E-05 8.55E-04 3.03E-06 2.52E-05 1.30 3 hsa-miR-20a,hsa-miR-27b,hsa-miR-363, Tripartite motif-containing protein 38 (RING finger protein 15)(Zinc TRIM38 ENSG00000112343 finger protein RoRet) [Source:UniProtKB/Swiss-Prot;Acc:O00635] 6.57 7.87 1.30 2.46 2.92E-05 3.76E-04 3.67E-05 2.38E-04 1.30 1 hsa-miR-7, RING finger protein 122 [Source:UniProtKB/Swiss- RNF122 ENSG00000133874 Prot;Acc:Q9H9V4] 5.86 7.16 1.30 2.47 2.10E-04 1.90E-03 2.86E-05 1.90E-04 1.30 1 hsa-miR-29b, Receptor expression-enhancing protein 3 [Source:UniProtKB/Swiss- REEP3 ENSG00000165476 Prot;Acc:Q6NUK4] 5.33 6.63 1.30 2.47 7.68E-05 8.33E-04 9.20E-07 8.57E-06 1.39 2 hsa-miR-19a,hsa-miR-424, Rab11 family-interacting protein 1 (Rab11-FIP1)(Rab-coupling RAB11FIP1 ENSG00000156675 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q6WKZ4] 5.94 7.25 1.30 2.47 2.86E-10 3.19E-08 3.98E-13 2.03E-11 1.42 3 hsa-miR-24,hsa-miR-27a,hsa-miR-7, Uncharacterized protein C17orf51 [Source:UniProtKB/Swiss- C17orf51 ENSG00000212719 Prot;Acc:A8MQB3] 5.24 6.55 1.30 2.47 2.43E-05 3.25E-04 2.40E-08 3.31E-07 1.76 2 hsa-miR-155,hsa-miR-7, WD repeat-containing protein 43 [Source:UniProtKB/Swiss- WDR43 ENSG00000163811 Prot;Acc:Q15061] 6.20 7.51 1.31 2.47 2.88E-04 2.46E-03 1.07E-07 1.27E-06 1.89 1 hsa-miR-27a, OTU domain-containing protein 4 (HIV-1-induced protein HIN-1) OTUD4 ENSG00000164164 [Source:UniProtKB/Swiss-Prot;Acc:Q01804] 6.83 8.14 1.31 2.48 1.10E-03 7.37E-03 3.87E-04 1.98E-03 1.31 4 hsa-miR-200b,hsa-miR-20a,hsa-miR-27a,hsa-miR-7, WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain-containing protein 1)(Phosphoinositide-binding protein 1)(FENS-1)(Zinc finger FYVE domain-containing protein 17) WDFY1 ENSG00000085449 [Source:UniProtKB/Swiss-Prot;Acc:Q8IWB7] 6.79 8.10 1.31 2.48 9.74E-05 1.01E-03 5.24E-06 4.13E-05 1.31 2 hsa-miR-155,hsa-miR-7, Uncharacterized potential DNA-binding protein C17orf49 C17orf49 ENSG00000161939 [Source:UniProtKB/Swiss-Prot;Acc:Q8IXM2] 7.94 9.25 1.31 2.48 2.23E-04 1.99E-03 7.97E-06 6.02E-05 1.31 1 hsa-miR-24, mRNA-decapping enzyme 2 (hDpc)(EC 3.-.-.-)(Nucleoside diphosphate-linked moiety X motif 20)(Nudix motif 20) hsa-miR-155,hsa-miR-19a,hsa-miR-206,hsa-miR-218,hsa-miR-27a,hsa-miR-363,hsa- DCP2 ENSG00000172795 [Source:UniProtKB/Swiss-Prot;Acc:Q8IU60] 6.29 7.60 1.31 2.48 1.41E-04 1.37E-03 6.18E-05 3.81E-04 1.31 8 miR-365,hsa-miR-7, ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1)(ATP-binding cassette 1)(ABC-1)(Cholesterol efflux ABCA1 ENSG00000165029 regulatory protein) [Source:UniProtKB/Swiss-Prot;Acc:O95477] 5.65 6.95 1.31 2.48 1.65E-06 3.70E-05 1.76E-06 1.54E-05 1.31 3 hsa-miR-19a,hsa-miR-27a,hsa-miR-7, Peroxiredoxin-2 (EC 1.11.1.15)(Thioredoxin peroxidase 1)(Thioredoxin- dependent peroxide reductase 1)(Thiol-specific antioxidant protein)(TSA)(PRP)(Natural killer cell-enhancing factor B)(NKEF-B) PRDX2 ENSG00000167815 [Source:UniProtKB/Swiss-Prot;Acc:P32119] 6.95 8.26 1.31 2.48 2.80E-05 3.64E-04 4.69E-08 6.02E-07 1.55 1 hsa-miR-200b, Tropomodulin-3 (Ubiquitous tropomodulin)(U-Tmod) TMOD3 ENSG00000138594 [Source:UniProtKB/Swiss-Prot;Acc:Q9NYL9] 6.19 7.50 1.31 2.48 2.08E-04 1.89E-03 1.70E-05 1.19E-04 1.31 1 hsa-miR-365, Cytosolic purine 5'-nucleotidase (EC 3.1.3.5)(5'-nucleotidase NT5C2 ENSG00000076685 cytosolic II) [Source:UniProtKB/Swiss-Prot;Acc:P49902] 6.60 7.91 1.31 2.48 2.45E-04 2.16E-03 6.89E-05 4.20E-04 1.31 1 hsa-miR-7, Glutaminase kidney isoform, mitochondrial Precursor (GLS)(EC 3.5.1.2)(L-glutamine amidohydrolase)(K-glutaminase) GLS ENSG00000115419 [Source:UniProtKB/Swiss-Prot;Acc:O94925] 7.00 8.31 1.31 2.48 3.78E-04 3.07E-03 5.88E-06 4.58E-05 1.66 4 hsa-miR-132,hsa-miR-155,hsa-miR-21,hsa-miR-7, Putative E3 ubiquitin-protein ligase UBR7 (EC 6.3.2.-)(N-recognin-7) UBR7 ENSG00000012963 [Source:UniProtKB/Swiss-Prot;Acc:Q8N806] 5.04 6.36 1.31 2.48 5.82E-06 1.02E-04 1.82E-10 4.36E-09 1.77 2 hsa-miR-27a,hsa-miR-7, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (NIP3- like protein X)(NIP3L)(BCL2/adenovirus E1B 19 kDa protein- interacting protein 3A)(Adenovirus E1B19K-binding protein B5) BNIP3L ENSG00000104765 [Source:UniProtKB/Swiss-Prot;Acc:O60238] 7.23 8.55 1.31 2.48 5.10E-06 9.20E-05 4.50E-05 2.87E-04 1.31 3 hsa-miR-24,hsa-miR-27a,hsa-miR-7, Actin-binding protein IPP (MIPP protein)(Kelch-like protein 27) IPP ENSG00000197429 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y573] 5.96 7.27 1.31 2.49 5.40E-04 4.12E-03 1.23E-03 5.54E-03 1.48 2 hsa-miR-21,hsa-miR-218, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Precursor (EC 2.3.1.12)(Pyruvate dehydrogenase complex E2 subunit)(PDC- E2)(PDCE2)(E2)(Dihydrolipoamide S-acetyltransferase component of DLAT ENSG00000150768 pyruvate dehyd 6.30 7.62 1.32 2.49 1.14E-05 1.76E-04 1.47E-11 4.73E-10 2.12 1 hsa-miR-365, Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4)(RING finger protein 51) [Source:UniProtKB/Swiss- BMI1 ENSG00000168283 Prot;Acc:P35226] 6.55 7.87 1.32 2.49 1.50E-03 9.40E-03 1.21E-04 6.97E-04 1.45 6 hsa-miR-132,hsa-miR-200b,hsa-miR-218,hsa-miR-221,hsa-miR-27a,hsa-miR-365, Ras-related protein Ral-A Precursor [Source:UniProtKB/Swiss- RALA ENSG00000006451 Prot;Acc:P11233] 6.51 7.82 1.32 2.49 4.38E-05 5.22E-04 1.30E-06 1.17E-05 1.32 3 hsa-miR-222,hsa-miR-24,hsa-miR-29b, C-Myc-binding protein (Associate of Myc 1)(AMY-1) MYCBP ENSG00000214114 [Source:UniProtKB/Swiss-Prot;Acc:Q99417] 5.69 7.01 1.32 2.49 5.53E-05 6.35E-04 1.69E-11 5.37E-10 2.61 2 hsa-miR-135b,hsa-miR-27a, E3 ubiquitin-protein ligase RAD18 (EC 6.3.2.-)(Postreplication repair protein RAD18)(hRAD18)(hHR18)(RING finger protein 73) RAD18 ENSG00000070950 [Source:UniProtKB/Swiss-Prot;Acc:Q9NS91] 5.90 7.22 1.32 2.50 5.63E-06 9.93E-05 2.28E-10 5.34E-09 1.71 2 hsa-miR-155,hsa-miR-7, Golgin subfamily A member 5 (Golgin-84)(RET-fused gene 5 GOLGA5 ENSG00000066455 protein)(Ret-II protein) [Source:UniProtKB/Swiss-Prot;Acc:Q8TBA6] 5.56 6.88 1.32 2.50 2.37E-04 2.09E-03 3.28E-05 2.15E-04 1.32 1 hsa-miR-7, Chondroitin sulfate synthase 1 (EC 2.4.1.175)(Glucuronosyl-N- acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase 1)(N-acetylgalactosaminyl- proteoglycan 3-beta-glucuronosyltransferase 1)(EC CHSY1 ENSG00000131873 2.4.1.226)(Chondroitin glucuronyltransferas 6.75 8.07 1.32 2.50 1.54E-08 8.33E-07 1.12E-11 3.73E-10 1.32 3 hsa-miR-155,hsa-miR-200b,hsa-miR-221, Uncharacterized protein C10orf58 Precursor C10orf57 ENSG00000122378 [Source:UniProtKB/Swiss-Prot;Acc:Q9BRX8] 5.74 7.06 1.32 2.50 8.03E-08 3.14E-06 5.97E-13 2.85E-11 1.86 2 hsa-miR-18a,hsa-miR-7, GC-rich sequence DNA-binding factor homolog C21orf66 ENSG00000159086 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5B6] 6.39 7.71 1.32 2.50 8.26E-05 8.81E-04 2.40E-05 1.62E-04 1.32 1 hsa-miR-155, Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)(p61-Yes)(c- YES1 ENSG00000176105 Yes) [Source:UniProtKB/Swiss-Prot;Acc:P07947] 5.86 7.19 1.32 2.50 4.88E-04 3.78E-03 6.95E-04 3.33E-03 1.32 5 hsa-miR-155,hsa-miR-19b,hsa-miR-20a,hsa-miR-27a,hsa-miR-7, BTB/POZ domain-containing protein KCTD9 KCTD9 ENSG00000104756 [Source:UniProtKB/Swiss-Prot;Acc:Q7L273] 6.18 7.51 1.32 2.50 5.34E-07 1.46E-05 5.14E-09 8.22E-08 1.32 2 hsa-miR-155,hsa-miR-218, Ras GTPase-activating protein-binding protein 1 (EC 3.6.1.-)(G3BP- 1)(ATP-dependent DNA helicase VIII)(HDH-VIII)(GAP SH3 domain- G3BP1 ENSG00000145907 binding protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q13283] 7.74 9.07 1.32 2.50 7.80E-05 8.43E-04 6.97E-10 1.42E-08 2.11 1 hsa-miR-132, Retinoblastoma-associated protein (pRb)(Rb)(pp110)(p105-Rb) RB1 ENSG00000139687 [Source:UniProtKB/Swiss-Prot;Acc:P06400] 5.99 7.32 1.32 2.50 2.50E-04 2.19E-03 7.51E-06 5.70E-05 1.62 4 hsa-miR-132,hsa-miR-155,hsa-miR-221,hsa-miR-7, Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand)(Fas ligand)(CD95L protein)(Apoptosis antigen ligand)(APTL)(CD178 antigen) [Contains Tumor necrosis factor ligand superfamily member 6, membrane form;Tumor necrosis factor FASLG ENSG00000117560 ligand superf 5.89 7.22 1.33 2.51 1.50E-06 3.44E-05 5.35E-10 1.13E-08 1.48 1 hsa-miR-24, Coatomer subunit delta (Delta-coat protein)(Delta-COP)(Archain) ARCN1 ENSG00000095139 [Source:UniProtKB/Swiss-Prot;Acc:P48444] 7.00 8.33 1.33 2.51 2.12E-05 2.91E-04 1.49E-07 1.70E-06 1.38 2 hsa-miR-424,hsa-miR-7, Sister chromatid cohesion protein PDS5 homolog A (Sister chromatid cohesion protein 112)(SCC-112)(Cell proliferation-inducing gene 54 PDS5A ENSG00000121892 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q29RF7] 6.67 8.00 1.33 2.51 7.92E-04 5.65E-03 8.03E-05 4.81E-04 1.42 2 hsa-miR-155,hsa-miR-222, Cystathionine beta-synthase (EC 4.2.1.22)(Serine sulfhydrase)(Beta- CBS ENSG00000160200 thionase) [Source:UniProtKB/Swiss-Prot;Acc:P35520] 6.25 7.58 1.33 2.51 4.69E-13 1.86E-10 1.37E-14 1.08E-12 1.41 1 hsa-miR-7, Hippocampus abundant transcript-like protein 1 HIATL1 ENSG00000148110 [Source:UniProtKB/Swiss-Prot;Acc:Q5SR56] 6.65 7.98 1.33 2.51 2.12E-05 2.91E-04 2.16E-09 3.84E-08 1.77 1 hsa-miR-210, Mannose-P-dolichol utilization defect 1 protein (Suppressor of Lec15 and Lec35 glycosylation mutation homolog)(SL15) MPDU1 ENSG00000129255 [Source:UniProtKB/Swiss-Prot;Acc:O75352] 6.73 8.06 1.33 2.51 1.68E-05 2.41E-04 1.42E-10 3.50E-09 1.97 1 hsa-miR-24, Splicing factor, arginine/serine-rich 1 (pre-mRNA-splicing factor SF2, P33 subunit)(Alternative-splicing factor 1)(ASF-1) SFRS1 ENSG00000136450 [Source:UniProtKB/Swiss-Prot;Acc:Q07955] 7.75 9.09 1.33 2.52 3.21E-04 2.69E-03 7.87E-07 7.47E-06 1.63 6 hsa-miR-155,hsa-miR-200b,hsa-miR-27a,hsa-miR-365,hsa-miR-424,hsa-miR-7, Ribulose-phosphate 3-epimerase (EC 5.1.3.1)(Ribulose-5-phosphate- RPE ENSG00000197713 3-epimerase) [Source:UniProtKB/Swiss-Prot;Acc:Q96AT9] 6.27 7.60 1.33 2.52 9.62E-06 1.53E-04 2.34E-09 4.12E-08 1.74 3 hsa-miR-155,hsa-miR-18a,hsa-miR-222, Zinc finger CCCH domain-containing protein 14 (Renal carcinoma ZC3H14 ENSG00000100722 antigen NY-REN-37) [Source:UniProtKB/Swiss-Prot;Acc:Q6PJT7] 6.01 7.34 1.34 2.52 3.70E-05 4.55E-04 5.50E-08 6.98E-07 1.57 1 hsa-miR-132, Histidyl-tRNA synthetase, cytoplasmic (EC 6.1.1.21)(Histidine--tRNA HARS ENSG00000170445 ligase)(HisRS) [Source:UniProtKB/Swiss-Prot;Acc:P12081] 6.29 7.63 1.34 2.53 1.00E-04 1.04E-03 6.39E-08 7.98E-07 1.75 1 hsa-miR-19a, Uncharacterized protein KIAA1467 [Source:UniProtKB/Swiss- KIAA1467 ENSG00000084444 Prot;Acc:A2RU67] 5.21 6.54 1.34 2.53 4.23E-06 7.89E-05 4.05E-08 5.27E-07 1.34 2 hsa-miR-132,hsa-miR-155, Double-strand break repair protein MRE11A (MRE11 meiotic recombination 11 homolog A)(MRE11 homolog 1) MRE11A ENSG00000020922 [Source:UniProtKB/Swiss-Prot;Acc:P49959] 5.86 7.20 1.34 2.53 3.39E-04 2.81E-03 1.69E-06 1.49E-05 1.57 2 hsa-miR-155,hsa-miR-221, Cytochrome c oxidase assembly protein COX15 homolog COX15 ENSG00000014919 [Source:UniProtKB/Swiss-Prot;Acc:Q7KZN9] 6.03 7.37 1.34 2.53 9.93E-06 1.57E-04 4.63E-08 5.95E-07 1.37 1 hsa-miR-135b, Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain)(GLUT-1)(HepG2 SLC2A1 ENSG00000117394 glucose transporter) [Source:UniProtKB/Swiss-Prot;Acc:P11166] 7.98 9.32 1.34 2.53 1.13E-07 4.18E-06 6.51E-08 8.12E-07 1.34 3 hsa-miR-130b,hsa-miR-132,hsa-miR-19a, Tyrosyl-tRNA synthetase, mitochondrial Precursor (EC 6.1.1.1)(Tyrosine--tRNA ligase)(TyrRS) [Source:UniProtKB/Swiss- YARS2 ENSG00000139131 Prot;Acc:Q9Y2Z4] 6.24 7.58 1.34 2.53 9.77E-06 1.55E-04 3.06E-09 5.23E-08 1.63 1 hsa-miR-424, Synaptotagmin-11 (Synaptotagmin XI)(SytXI) SYT11 ENSG00000132718 [Source:UniProtKB/Swiss-Prot;Acc:Q9BT88] 5.78 7.12 1.34 2.53 1.22E-04 1.21E-03 2.44E-05 1.65E-04 1.42 2 hsa-miR-19a,hsa-miR-218, Vacuolar protein sorting-associated protein 41 homolog (S53) VPS41 ENSG00000006715 [Source:UniProtKB/Swiss-Prot;Acc:P49754] 6.47 7.81 1.34 2.53 1.16E-04 1.17E-03 4.12E-06 3.33E-05 1.34 1 hsa-miR-132, Interleukin-1 receptor type I Precursor (IL-1R-1)(IL-1RT1)(IL-1R- alpha)(p80)(CD121 antigen-like family member A)(CD121a antigen) IL1R1 ENSG00000115594 [Source:UniProtKB/Swiss-Prot;Acc:P14778] 5.02 6.37 1.34 2.53 1.65E-07 5.66E-06 3.51E-10 7.78E-09 1.58 3 hsa-miR-19a,hsa-miR-24,hsa-miR-7, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A, subunit B, B-alpha isoform)(PP2A, subunit B, B55-alpha isoform)(PP2A, subunit B, PR55-alpha isoform)(PP2A, PPP2R2A ENSG00000221914 subunit B, R2-alpha isoform) [Source:UniProtKB/Swiss-Prot;A 6.83 8.17 1.34 2.54 3.36E-05 4.22E-04 4.63E-07 4.65E-06 1.34 2 hsa-miR-218,hsa-miR-222, LAG1 longevity assurance homolog 5 [Source:UniProtKB/Swiss- LASS5 ENSG00000139624 Prot;Acc:Q8N5B7] 6.74 8.08 1.34 2.54 1.36E-05 2.03E-04 7.59E-08 9.31E-07 1.34 1 hsa-miR-18a, Arginine/serine-rich coiled-coil protein 1 [Source:UniProtKB/Swiss- RSRC1 ENSG00000174891 Prot;Acc:Q96IZ7] 5.62 6.97 1.34 2.54 7.79E-04 5.57E-03 3.04E-06 2.52E-05 1.79 1 hsa-miR-132, F-box-like/WD repeat-containing protein TBL1XR1 (Transducin beta- like 1X-related protein 1)(Nuclear receptor corepressor/HDAC3 complex subunit TBLR1)(TBL1-related protein 1) TBL1XR1 ENSG00000177565 [Source:UniProtKB/Swiss-Prot;Acc:Q9BZK7] 6.96 8.30 1.34 2.54 1.78E-04 1.66E-03 1.25E-05 9.06E-05 1.34 2 hsa-miR-200b,hsa-miR-363, Endothelial PAS domain-containing protein 1 (EPAS-1)(Member of PAS protein 2)(Basic-helix-loop-helix-PAS protein MOP2)(Hypoxia- inducible factor 2 alpha)(HIF-2 alpha)(HIF2 alpha)(HIF-1 alpha-like EPAS1 ENSG00000116016 factor)(HLF) [Source:UniProtKB/Swiss-Prot;Acc:Q99814] 5.35 6.70 1.34 2.54 4.00E-08 1.78E-06 1.29E-09 2.44E-08 1.35 4 hsa-miR-155,hsa-miR-19a,hsa-miR-27a,hsa-miR-365, DNA polymerase eta (EC 2.7.7.7)(RAD30 homolog A)(Xeroderma pigmentosum variant type protein) [Source:UniProtKB/Swiss- POLH ENSG00000170734 Prot;Acc:Q9Y253] 5.72 7.06 1.34 2.54 7.67E-06 1.28E-04 3.51E-07 3.62E-06 1.34 3 hsa-miR-200b,hsa-miR-218,hsa-miR-24, DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1)(UV-damaged DNA-binding factor)(DDB p127 subunit)(DNA damage-binding protein a)(DDBa)(UV-damaged DNA- binding protein 1)(UV-DDB 1)(Xeroderma pigmentosum group E- DDB1 ENSG00000167986 complementing protein)(XPCe 6.71 8.05 1.35 2.54 9.03E-06 1.45E-04 3.87E-11 1.12E-09 1.92 1 hsa-miR-18a, Protein sel-1 homolog 1 Precursor (Suppressor of lin-12-like protein SEL1L ENSG00000071537 1)(Sel-1L) [Source:UniProtKB/Swiss-Prot;Acc:Q9UBV2] 6.96 8.31 1.35 2.54 4.97E-05 5.81E-04 8.44E-06 6.34E-05 1.35 3 hsa-miR-132,hsa-miR-19a,hsa-miR-7, Amine oxidase [flavin-containing] A (EC 1.4.3.4)(Monoamine oxidase MAOA ENSG00000189221 type A)(MAO-A) [Source:UniProtKB/Swiss-Prot;Acc:P21397] 4.80 6.15 1.35 2.55 9.09E-07 2.26E-05 9.31E-07 8.66E-06 1.81 1 hsa-miR-7, Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein) [Source:UniProtKB/Swiss- ARMC10 ENSG00000170632 Prot;Acc:Q8N2F6] 5.57 6.92 1.35 2.55 1.23E-04 1.21E-03 9.90E-08 1.18E-06 1.84 1 hsa-miR-7, Probable ribosome biogenesis protein RLP24 (Ribosomal protein L24- C15orf15 ENSG00000137876 like) [Source:UniProtKB/Swiss-Prot;Acc:Q9UHA3] 8.46 9.81 1.35 2.56 6.42E-05 7.20E-04 1.53E-07 1.74E-06 1.35 1 hsa-miR-132, 28S ribosomal protein S10, mitochondrial (S10mt)(MRP-S10) MRPS10 ENSG00000048544 [Source:UniProtKB/Swiss-Prot;Acc:P82664] 6.34 7.69 1.36 2.56 3.57E-05 4.42E-04 3.10E-09 5.28E-08 1.88 1 hsa-miR-155, Probable histone-lysine N-methyltransferase NSD2 (EC 2.1.1.43)(Nuclear SET domain-containing protein 2)(Wolf-Hirschhorn syndrome candidate 1 protein)(Multiple myeloma SET domain- containing protein)(Protein trithorax-5) [Source:UniProtKB/Swiss- WHSC1 ENSG00000109685 Prot;Acc:O96 6.03 7.39 1.36 2.56 8.38E-11 1.20E-08 3.62E-14 2.55E-12 1.36 3 hsa-miR-18a,hsa-miR-200b,hsa-miR-7, Schlafen family member 11 [Source:UniProtKB/Swiss- SLFN11 ENSG00000172716 Prot;Acc:Q7Z7L1] 6.17 7.53 1.36 2.57 1.03E-04 1.06E-03 3.02E-06 2.51E-05 1.36 2 hsa-miR-155,hsa-miR-7, Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.1.2.15)(Ubiquitin thioesterase 12)(Ubiquitin-specific-processing protease 12)(Deubiquitinating enzyme 12)(Ubiquitin-hydrolyzing enzyme 1) USP12 ENSG00000152484 [Source:UniProtKB/Swiss-Prot;Acc:O75317] 7.30 8.66 1.36 2.57 7.96E-06 1.31E-04 3.97E-08 5.17E-07 1.39 1 hsa-miR-19a, V-type proton ATPase subunit E 1 (V-ATPase subunit E 1)(Vacuolar proton pump subunit E 1)(V-ATPase 31 kDa subunit)(P31) ATP6V1E1 ENSG00000131100 [Source:UniProtKB/Swiss-Prot;Acc:P36543] 6.90 8.26 1.36 2.57 5.07E-05 5.91E-04 1.70E-07 1.91E-06 1.59 1 hsa-miR-132, DNA mismatch repair protein Msh3 (Divergent upstream protein)(DUP)(Mismatch repair protein 1)(MRP1) MSH3 ENSG00000113318 [Source:UniProtKB/Swiss-Prot;Acc:P20585] 6.11 7.47 1.36 2.57 4.17E-04 3.33E-03 1.67E-05 1.17E-04 1.36 1 hsa-miR-7, MTX3 ENSG00000177034 Metaxin-3 [Source:UniProtKB/Swiss-Prot;Acc:Q5HYI7] 5.66 7.02 1.36 2.57 2.27E-04 2.03E-03 2.54E-06 2.15E-05 1.37 2 hsa-miR-155,hsa-miR-7, AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B)(Mrf1-like)(Modulator recognition factor ARID5B ENSG00000150347 2)(MRF-2) [Source:UniProtKB/Swiss-Prot;Acc:Q14865] 7.19 8.56 1.36 2.57 3.73E-05 4.57E-04 4.44E-06 3.56E-05 1.36 3 hsa-miR-19b,hsa-miR-24,hsa-miR-27a, Keratinocyte-associated transmembrane protein 2 Precursor C5orf15 ENSG00000113583 [Source:UniProtKB/Swiss-Prot;Acc:Q8NC54] 6.10 7.47 1.36 2.57 3.13E-05 4.00E-04 3.44E-07 3.55E-06 1.38 4 hsa-miR-218,hsa-miR-221,hsa-miR-27a,hsa-miR-7, 14-3-3 protein eta (Protein AS1) [Source:UniProtKB/Swiss- YWHAH ENSG00000128245 Prot;Acc:Q04917] 6.36 7.73 1.36 2.57 3.46E-07 1.02E-05 1.04E-11 3.50E-10 1.77 2 hsa-miR-132,hsa-miR-365, NF-kappa-B-repressing factor (NFkB-repressing factor)(Transcription factor NRF)(ITBA4 protein) NKRF ENSG00000186416 [Source:UniProtKB/Swiss-Prot;Acc:O15226] 5.49 6.85 1.37 2.58 1.18E-05 1.81E-04 8.43E-10 1.68E-08 1.72 1 hsa-miR-29b, Cell division cycle-associated protein 4 (Hematopoietic progenitor CDCA4 ENSG00000170779 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9BXL8] 6.85 8.22 1.37 2.58 2.97E-08 1.41E-06 1.25E-12 5.49E-11 1.67 1 hsa-miR-424, Interferon-induced guanylate-binding protein 1 (Guanine nucleotide- binding protein 1)(GTP-binding protein 1)(GBP-1)(HuGBP-1) GBP1 ENSG00000117228 [Source:UniProtKB/Swiss-Prot;Acc:P32455] 6.01 7.38 1.37 2.59 1.45E-04 1.40E-03 3.22E-05 2.12E-04 1.37 2 hsa-miR-18a,hsa-miR-7, Down syndrome critical region protein 3 (Down syndrome critical DSCR3 ENSG00000157538 region protein A) [Source:UniProtKB/Swiss-Prot;Acc:O14972] 6.05 7.42 1.37 2.59 7.61E-04 5.47E-03 1.06E-04 6.20E-04 1.37 1 hsa-miR-424, Zinc finger protein 410 (Zinc finger protein APA-1)(Another partner ZNF410 ENSG00000119725 for ARF 1) [Source:UniProtKB/Swiss-Prot;Acc:Q86VK4] 6.56 7.94 1.37 2.59 1.86E-05 2.62E-04 2.36E-06 2.01E-05 1.37 1 hsa-miR-132, KLHL6 ENSG00000172578 Kelch-like protein 6 [Source:UniProtKB/Swiss-Prot;Acc:Q8WZ60] 6.73 8.11 1.37 2.59 7.91E-06 1.31E-04 2.87E-07 3.02E-06 1.37 1 hsa-miR-7,

MIS12 ENSG00000167842 Protein MIS12 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q9H081] 6.56 7.93 1.37 2.59 5.10E-05 5.95E-04 1.83E-07 2.04E-06 1.52 1 hsa-miR-7, Trafficking protein particle complex subunit 4 (Synbindin)(TRS23 homolog)(Hematopoietic stem/progenitor cell protein 172) TRAPPC4 ENSG00000196655 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y296] 6.96 8.34 1.37 2.59 2.38E-04 2.10E-03 1.74E-09 3.17E-08 2.52 1 hsa-miR-24, E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-)(E3 ubiquitin-protein ligase, HECT domain-containing 1)(Hyperplastic discs protein homolog)(hHYD)(Progestin-induced protein) UBR5 ENSG00000104517 [Source:UniProtKB/Swiss-Prot;Acc:O95071] 6.39 7.76 1.37 2.59 7.28E-05 7.97E-04 2.48E-05 1.67E-04 1.37 1 hsa-miR-27a, Polycomb group RING finger protein 6 (RING finger protein 134)(Mel18 and Bmi1-like RING finger) [Source:UniProtKB/Swiss- PCGF6 ENSG00000156374 Prot;Acc:Q9BYE7] 5.33 6.70 1.37 2.59 2.44E-04 2.15E-03 1.53E-06 1.35E-05 1.72 1 hsa-miR-7, PHB ENSG00000167085 Prohibitin [Source:UniProtKB/Swiss-Prot;Acc:P35232] 7.71 9.08 1.38 2.60 7.89E-06 1.31E-04 3.03E-12 1.19E-10 2.20 2 hsa-miR-27b,hsa-miR-7, Phosphatidylinositol-glycan biosynthesis class X protein Precursor PIGX ENSG00000163964 (PIG-X) [Source:UniProtKB/Swiss-Prot;Acc:Q8TBF5] 5.94 7.32 1.38 2.60 1.28E-05 1.93E-04 1.63E-09 2.99E-08 1.84 1 hsa-miR-132, SESN2 ENSG00000130766 Sestrin-2 (Hi95) [Source:UniProtKB/Swiss-Prot;Acc:P58004] 5.79 7.17 1.38 2.60 6.74E-08 2.75E-06 4.18E-10 9.09E-09 1.39 3 hsa-miR-221,hsa-miR-27a,hsa-miR-93, Reticulon-3 (Neuroendocrine-specific protein-like 2)(NSP-like protein RTN3 ENSG00000133318 II)(NSPLII) [Source:UniProtKB/Swiss-Prot;Acc:O95197] 7.94 9.32 1.38 2.60 8.36E-05 8.89E-04 1.39E-07 1.60E-06 1.65 2 hsa-miR-155,hsa-miR-218, T-complex protein 1 subunit gamma (TCP-1-gamma)(CCT- CCT3 ENSG00000163468 gamma)(hTRiC5) [Source:UniProtKB/Swiss-Prot;Acc:P49368] 6.49 7.87 1.38 2.60 3.65E-06 7.06E-05 6.61E-11 1.80E-09 2.07 1 hsa-miR-24, Transcription factor RelB (I-Rel) [Source:UniProtKB/Swiss- RELB ENSG00000104856 Prot;Acc:Q01201] 6.24 7.62 1.38 2.60 1.91E-08 9.98E-07 7.05E-11 1.90E-09 1.38 1 hsa-miR-7, Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3)(Kappa-B and V(D)J recombination signal sequences-binding protein)(Zinc finger protein ZAS3)(Kappa-binding HIVEP3 ENSG00000127124 protein 1)(KBP-1) [Source:UniProtKB/Swiss-Prot;Acc:Q5T1R 5.53 6.91 1.38 2.60 4.08E-10 4.32E-08 2.90E-13 1.55E-11 1.41 1 hsa-miR-27a, Methylmalonyl-CoA mutase, mitochondrial Precursor (MCM)(EC 5.4.99.2)(Methylmalonyl-CoA isomerase) [Source:UniProtKB/Swiss- MUT ENSG00000146085 Prot;Acc:P22033] 6.04 7.42 1.38 2.60 1.20E-04 1.20E-03 3.78E-06 3.07E-05 1.38 1 hsa-miR-155, Beta-adrenergic receptor kinase 2 (Beta-ARK-2)(EC 2.7.11.15)(G- protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss- ADRBK2 ENSG00000100077 Prot;Acc:P35626] 5.06 6.44 1.38 2.60 7.16E-09 4.40E-07 1.29E-12 5.64E-11 1.82 6 hsa-miR-132,hsa-miR-155,hsa-miR-19a,hsa-miR-218,hsa-miR-7,hsa-miR-98, Pituitary tumor-transforming gene 1 protein-interacting protein Precursor (Pituitary tumor-transforming gene protein-binding factor)(PTTG-binding factor)(PBF) [Source:UniProtKB/Swiss- PTTG1IP ENSG00000183255 Prot;Acc:P53801] 6.52 7.90 1.38 2.61 2.10E-05 2.90E-04 1.09E-06 1.00E-05 1.38 1 hsa-miR-365, A-kinase anchor protein 11 (Protein kinase A-anchoring protein 11)(PRKA11)(A kinase anchor protein 220 kDa)(AKAP AKAP11 ENSG00000023516 220)(hAKAP220) [Source:UniProtKB/Swiss-Prot;Acc:Q9UKA4] 6.07 7.46 1.39 2.61 8.14E-05 8.71E-04 1.74E-06 1.53E-05 1.39 1 hsa-miR-7, DnaJ homolog subfamily C member 9 (DnaJ protein SB73) DNAJC9 ENSG00000213551 [Source:UniProtKB/Swiss-Prot;Acc:Q8WXX5] 7.56 8.95 1.39 2.61 5.61E-04 4.27E-03 6.13E-07 5.97E-06 1.99 1 hsa-miR-7, Dynein light chain Tctex-type 3 (T-complex-associated testis- expressed 1-like)(Protein 91/23) [Source:UniProtKB/Swiss- DYNLT3 ENSG00000165169 Prot;Acc:P51808] 6.61 8.00 1.39 2.61 2.30E-04 2.05E-03 3.71E-05 2.40E-04 1.39 1 hsa-miR-363, Protein FAM83D (Spindle protein CHICA) [Source:UniProtKB/Swiss- FAM83D ENSG00000101447 Prot;Acc:Q9H4H8] 5.94 7.32 1.39 2.61 5.27E-09 3.47E-07 2.43E-10 5.63E-09 1.39 2 hsa-miR-19a,hsa-miR-7, Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)(Oxidative stress- OXSR1 ENSG00000172939 responsive 1 protein) [Source:UniProtKB/Swiss-Prot;Acc:O95747] 6.62 8.01 1.39 2.61 2.52E-05 3.34E-04 6.28E-06 4.85E-05 1.39 3 hsa-miR-218,hsa-miR-24,hsa-miR-7, 60S ribosomal export protein NMD3 (hNMD3) NMD3 ENSG00000169251 [Source:UniProtKB/Swiss-Prot;Acc:Q96D46] 6.26 7.65 1.39 2.62 1.58E-04 1.50E-03 2.70E-06 2.26E-05 1.42 2 hsa-miR-200b,hsa-miR-424,

ATP synthase mitochondrial F1 complex assembly factor 1 Precursor ATPAF1 ENSG00000123472 (ATP11 homolog) [Source:UniProtKB/Swiss-Prot;Acc:Q5TC12] 5.76 7.15 1.39 2.62 7.47E-04 5.39E-03 6.50E-06 5.00E-05 1.90 2 hsa-miR-21,hsa-miR-27a, Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit)(TAFII-105)(TAFII105) TAF4B ENSG00000141384 [Source:UniProtKB/Swiss-Prot;Acc:Q92750] 5.64 7.03 1.39 2.62 1.20E-04 1.20E-03 2.99E-05 1.98E-04 1.39 3 hsa-miR-132,hsa-miR-155,hsa-miR-7, Pyridine nucleotide-disulfide oxidoreductase domain-containing PYROXD1 ENSG00000121350 protein 1 (EC 1.8.1.-) [Source:UniProtKB/Swiss-Prot;Acc:Q8WU10] 6.29 7.68 1.39 2.62 1.08E-04 1.10E-03 1.24E-05 8.96E-05 1.39 1 hsa-miR-7, Actin-related protein 6 (hArp6)(hARPX) [Source:UniProtKB/Swiss- ACTR6 ENSG00000075089 Prot;Acc:Q9GZN1] 5.75 7.14 1.39 2.62 1.50E-03 9.38E-03 2.93E-05 1.94E-04 1.55 1 hsa-miR-21, SACS ENSG00000151835 Sacsin [Source:UniProtKB/Swiss-Prot;Acc:Q9NZJ4] 5.58 6.97 1.39 2.62 1.03E-04 1.06E-03 1.56E-08 2.24E-07 1.94 2 hsa-miR-218,hsa-miR-221, Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8)(APC8)(Cyclosome subunit 8) [Source:UniProtKB/Swiss- CDC23 ENSG00000094880 Prot;Acc:Q9UJX2] 6.06 7.44 1.39 2.62 1.14E-04 1.15E-03 1.02E-07 1.21E-06 1.72 2 hsa-miR-20a,hsa-miR-7, TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) TRAFD1 ENSG00000135148 [Source:UniProtKB/Swiss-Prot;Acc:O14545] 5.89 7.28 1.39 2.62 7.94E-05 8.53E-04 1.64E-06 1.45E-05 1.39 1 hsa-miR-29b, Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA- binding protein 1)(PAI-RBP1)(SERPINE1 mRNA-binding protein 1) SERBP1 ENSG00000142864 [Source:UniProtKB/Swiss-Prot;Acc:Q8NC51] 7.13 8.52 1.39 2.62 2.94E-05 3.79E-04 1.70E-10 4.10E-09 1.99 2 hsa-miR-218,hsa-miR-27a, Acetyl-coenzyme A transporter 1 (AT-1)(Acetyl-CoA transporter)(Solute carrier family 33 member 1) SLC33A1 ENSG00000169359 [Source:UniProtKB/Swiss-Prot;Acc:O00400] 6.80 8.19 1.39 2.62 3.18E-05 4.04E-04 7.12E-07 6.81E-06 1.39 1 hsa-miR-155, BRISC complex subunit Abro1 (Abraxas brother protein 1)(Protein FAM175B ENSG00000165660 FAM175B) [Source:UniProtKB/Swiss-Prot;Acc:Q15018] 6.01 7.40 1.39 2.63 1.62E-04 1.54E-03 3.23E-06 2.66E-05 1.55 2 hsa-miR-218,hsa-miR-24, Hexokinase-1 (EC 2.7.1.1)(Hexokinase type I)(HK I)(Brain form HK1 ENSG00000156515 hexokinase) [Source:UniProtKB/Swiss-Prot;Acc:P19367] 6.28 7.67 1.40 2.64 3.25E-06 6.45E-05 5.55E-09 8.82E-08 1.47 1 hsa-miR-155, Zinc transporter ZIP14 Precursor (Zrt- and Irt-like protein 14)(ZIP- 14)(Solute carrier family 39 member 14)(LIV-1 subfamily of ZIP zinc SLC39A14 ENSG00000104635 transporter 4)(LZT-Hs4) [Source:UniProtKB/Swiss-Prot;Acc:Q15043] 5.55 6.95 1.40 2.64 2.07E-11 3.92E-09 1.20E-17 2.43E-15 1.85 3 hsa-miR-200b,hsa-miR-218,hsa-miR-7, 39S ribosomal protein L22, mitochondrial Precursor (L22mt)(MRP- MRPL22 ENSG00000082515 L22)(MRP-L25) [Source:UniProtKB/Swiss-Prot;Acc:Q9NWU5] 5.98 7.38 1.40 2.64 2.86E-05 3.70E-04 1.63E-07 1.84E-06 1.76 5 hsa-miR-155,hsa-miR-218,hsa-miR-221,hsa-miR-365,hsa-miR-7, Protein GPR108 Precursor (Lung seven transmembrane receptor 2) GPR108 ENSG00000125734 [Source:UniProtKB/Swiss-Prot;Acc:Q9NPR9] 6.30 7.70 1.40 2.64 1.72E-06 3.82E-05 1.39E-09 2.60E-08 1.46 1 hsa-miR-7, Phosphatidylserine synthase 1 (PtdSer synthase 1)(PSS-1)(EC 2.7.8.- )(Serine-exchange enzyme I) [Source:UniProtKB/Swiss- PTDSS1 ENSG00000156471 Prot;Acc:P48651] 7.26 8.66 1.40 2.64 3.97E-05 4.82E-04 2.59E-06 2.18E-05 1.40 2 hsa-miR-155,hsa-miR-200b, ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-)(YME1-like protein 1)(ATP-dependent metalloprotease FtsH1)(Meg-4)(Presenilin- associated metalloprotease)(PAMP) [Source:UniProtKB/Swiss- YME1L1 ENSG00000136758 Prot;Acc:Q96TA2] 7.54 8.94 1.40 2.64 1.78E-04 1.66E-03 1.57E-05 1.11E-04 1.40 2 hsa-miR-155,hsa-miR-200b, Leucine-rich repeat-containing protein 59 [Source:UniProtKB/Swiss- LRRC59 ENSG00000108829 Prot;Acc:Q96AG4] 5.80 7.20 1.40 2.64 1.74E-05 2.48E-04 7.83E-11 2.07E-09 2.23 3 hsa-miR-155,hsa-miR-206,hsa-miR-7, UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9)(UDP- glucose pyrophosphorylase)(UDPGP)(UGPase) UGP2 ENSG00000169764 [Source:UniProtKB/Swiss-Prot;Acc:Q16851] 6.73 8.13 1.40 2.64 1.46E-03 9.19E-03 2.53E-04 1.35E-03 1.40 1 hsa-miR-218, Interleukin-1 receptor accessory protein Precursor (IL-1 receptor accessory protein)(IL-1RAcP) [Source:UniProtKB/Swiss- IL1RAP ENSG00000196083 Prot;Acc:Q9NPH3] 5.74 7.14 1.40 2.64 6.75E-08 2.75E-06 3.44E-08 4.54E-07 1.40 4 hsa-miR-130b,hsa-miR-155,hsa-miR-19a,hsa-miR-365, Transmembrane protein 173 (Stimulator of interferon genes protein)(hSTING)(Mediator of IRF3 activation)(hMITA) TMEM173 ENSG00000184584 [Source:UniProtKB/Swiss-Prot;Acc:Q86WV6] 7.53 8.94 1.40 2.64 9.46E-07 2.33E-05 5.80E-10 1.21E-08 1.59 1 hsa-miR-24, Zinc transporter 9 (ZnT-9)(Solute carrier family 30 member 9)(Human embryonic lung protein)(HUEL) [Source:UniProtKB/Swiss- SLC30A9 ENSG00000014824 Prot;Acc:Q6PML9] 5.58 6.98 1.40 2.65 3.00E-04 2.54E-03 6.51E-06 5.01E-05 1.61 1 hsa-miR-365, Eukaryotic translation initiation factor 2A (eIF-2A)(65 kDa eukaryotic translation initiation factor 2A) [Source:UniProtKB/Swiss- EIF2A ENSG00000144895 Prot;Acc:Q9BY44] 7.20 8.60 1.40 2.65 2.62E-04 2.27E-03 3.43E-05 2.23E-04 1.40 1 hsa-miR-18a, Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19)(Ubiquitin-protein ligase R2)(Ubiquitin carrier protein R2)(E2-CDC34B) UBE2R2 ENSG00000107341 [Source:UniProtKB/Swiss-Prot;Acc:Q712K3] 7.18 8.59 1.40 2.65 2.34E-05 3.15E-04 3.04E-06 2.52E-05 1.40 2 hsa-miR-200b,hsa-miR-7, Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2)(Demethylase)(DMTase) [Source:UniProtKB/Swiss- MBD2 ENSG00000134046 Prot;Acc:Q9UBB5] 7.41 8.82 1.40 2.65 2.50E-04 2.19E-03 2.33E-04 1.26E-03 1.40 3 hsa-miR-155,hsa-miR-222,hsa-miR-7, Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin KIF3B ENSG00000101350 motor 3B)(HH0048) [Source:UniProtKB/Swiss-Prot;Acc:O15066] 6.12 7.53 1.41 2.65 1.15E-09 9.87E-08 7.31E-15 6.27E-13 1.42 3 hsa-miR-18a,hsa-miR-24,hsa-miR-7, Protein transport protein Sec23A (SEC23-related protein A) SEC23A ENSG00000100934 [Source:UniProtKB/Swiss-Prot;Acc:Q15436] 6.64 8.05 1.41 2.65 1.72E-04 1.61E-03 1.94E-05 1.34E-04 1.41 2 hsa-miR-200b,hsa-miR-222, Prostaglandin E synthase 3 (EC 5.3.99.3)(Cytosolic prostaglandin E2 synthase)(cPGES)(Telomerase-binding protein p23)(Hsp90 co- chaperone)(Progesterone receptor complex p23) PTGES3 ENSG00000110958 [Source:UniProtKB/Swiss-Prot;Acc:Q15185] 8.04 9.44 1.41 2.65 3.46E-05 4.32E-04 2.27E-08 3.14E-07 1.78 2 hsa-miR-18a,hsa-miR-19a, Protein SET (Phosphatase 2A inhibitor I2PP2A)(I-2PP2A)(Template- activating factor I)(TAF-I)(HLA-DR-associated protein II)(PHAPII)(Inhibitor of granzyme A-activated DNase)(IGAAD) SET ENSG00000119335 [Source:UniProtKB/Swiss-Prot;Acc:Q01105] 7.45 8.86 1.41 2.66 1.22E-04 1.21E-03 8.79E-08 1.06E-06 1.80 1 hsa-miR-365, Programmed cell death protein 10 (TF-1 cell apoptosis-related protein 15)(Cerebral cavernous malformations 3 protein) PDCD10 ENSG00000114209 [Source:UniProtKB/Swiss-Prot;Acc:Q9BUL8] 6.48 7.89 1.41 2.66 1.75E-04 1.63E-03 4.84E-06 3.85E-05 1.66 1 hsa-miR-222, WD repeat domain phosphoinositide-interacting protein 3 (WIPI- 3)(WD repeat-containing protein 45-like)(WDR45-like WDR45L ENSG00000141580 protein)(WIPI49-like protein) [Source:UniProtKB/Swiss- 6.93 8.35 1.42 2.67 8.78E-05 9.25E-04 1.49E-05 1.06E-04 1.42 2 hsa-miR-19a,hsa-miR-200b, Casein kinase I isoform alpha (CKI-alpha)(EC 2.7.11.1)(CK1) CSNK1A1 ENSG00000113712 [Source:UniProtKB/Swiss-Prot;Acc:P48729] 6.85 8.27 1.42 2.67 7.97E-04 5.67E-03 2.29E-04 1.24E-03 1.42 1 hsa-miR-155, Protein kinase C iota type (EC 2.7.11.13)(nPKC-iota)(Atypical protein kinase C-lambda/iota)(aPKC-lambda/iota)(PRKC-lambda/iota) PRKCI ENSG00000163558 [Source:UniProtKB/Swiss-Prot;Acc:P41743] 6.32 7.74 1.42 2.68 1.48E-05 2.18E-04 4.75E-08 6.09E-07 1.42 3 hsa-miR-155,hsa-miR-18a,hsa-miR-24, Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X EIF1AX ENSG00000173674 isoform)(eIF-4C) [Source:UniProtKB/Swiss-Prot;Acc:P47813] 7.32 8.74 1.42 2.68 8.77E-04 6.14E-03 5.83E-07 5.70E-06 2.15 1 hsa-miR-21, Methionine aminopeptidase 2 (MetAP 2)(MAP 2)(EC 3.4.11.18)(Peptidase M 2)(Initiation factor 2-associated 67 kDa glycoprotein)(p67eIF2)(p67) [Source:UniProtKB/Swiss- METAP2 ENSG00000111142 Prot;Acc:P50579] 6.68 8.10 1.42 2.68 1.61E-05 2.33E-04 2.80E-08 3.78E-07 1.65 1 hsa-miR-155, Exosome complex exonuclease RRP4 (EC 3.1.13.-)(Ribosomal RNA- processing protein 4)(Exosome component 2) EXOSC2 ENSG00000130713 [Source:UniProtKB/Swiss-Prot;Acc:Q13868] 6.67 8.09 1.42 2.68 1.89E-05 2.65E-04 7.72E-12 2.71E-10 2.15 2 hsa-miR-155,hsa-miR-7, Inducible T-cell costimulator Precursor (Activation-inducible lymphocyte immunomediatory molecule)(CD278 antigen) ICOS ENSG00000163600 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y6W8] 8.18 9.60 1.42 2.68 1.10E-04 1.11E-03 7.71E-07 7.33E-06 1.56 2 hsa-miR-24,hsa-miR-27a, Sentrin-specific protease 1 (EC 3.4.22.-)(Sentrin/SUMO-specific SENP1 ENSG00000079387 protease SENP1) [Source:UniProtKB/Swiss-Prot;Acc:Q9P0U3] 5.79 7.21 1.42 2.68 6.85E-06 1.16E-04 4.62E-09 7.49E-08 1.76 2 hsa-miR-218,hsa-miR-27a, OTU domain-containing protein 7B (EC 3.-.-.-)(Zinc finger protein Cezanne)(Zinc finger A20 domain-containing protein 1)(Cellular zinc finger anti-NF-kappa-B protein) [Source:UniProtKB/Swiss- OTUD7B ENSG00000163113 Prot;Acc:Q6GQQ9] 5.57 6.99 1.42 2.68 8.53E-09 5.11E-07 2.28E-12 9.22E-11 1.42 4 hsa-miR-135b,hsa-miR-155,hsa-miR-19a,hsa-miR-218, Solute carrier family 35 member E1 [Source:UniProtKB/Swiss- SLC35E1 ENSG00000127526 Prot;Acc:Q96K37] 7.28 8.70 1.42 2.68 6.42E-06 1.10E-04 6.78E-08 8.43E-07 1.42 1 hsa-miR-19a, Vigilin (High density lipoprotein-binding protein)(HDL-binding HDLBP ENSG00000115677 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q00341] 6.99 8.42 1.43 2.69 1.79E-07 6.07E-06 5.91E-11 1.63E-09 1.45 3 hsa-miR-19a,hsa-miR-363,hsa-miR-7, Bifunctional apoptosis regulator (RING finger protein 47) BFAR ENSG00000103429 [Source:UniProtKB/Swiss-Prot;Acc:Q9NZS9] 5.99 7.42 1.43 2.69 3.82E-04 3.10E-03 6.03E-05 3.73E-04 1.43 1 hsa-miR-424, tRNA wybutosine-synthesizing protein 3 homolog (EC 2.1.1.-)(tRNA- yW-synthesizing protein 3) [Source:UniProtKB/Swiss- TYW3 ENSG00000162623 Prot;Acc:Q6IPR3] 6.65 8.08 1.43 2.69 1.12E-06 2.68E-05 2.39E-11 7.30E-10 1.81 2 hsa-miR-155,hsa-miR-7, G-rich sequence factor 1 (GRSF-1) [Source:UniProtKB/Swiss- GRSF1 ENSG00000132463 Prot;Acc:Q12849] 6.91 8.34 1.43 2.69 2.68E-05 3.51E-04 1.47E-07 1.68E-06 1.47 4 hsa-miR-19a,hsa-miR-21,hsa-miR-218,hsa-miR-27a, Zinc transporter 6 (ZnT-6)(Solute carrier family 30 member 6) SLC30A6 ENSG00000152683 [Source:UniProtKB/Swiss-Prot;Acc:Q6NXT4] 6.01 7.44 1.43 2.70 7.75E-05 8.38E-04 2.11E-07 2.31E-06 1.74 2 hsa-miR-132,hsa-miR-18a, Protein tyrosine phosphatase-like protein PTPLAD1 (Protein-tyrosine phosphatase-like A domain-containing protein 1)(Butyrate-induced protein 1)(hB-ind1)(B-ind1) [Source:UniProtKB/Swiss- PTPLAD1 ENSG00000074696 Prot;Acc:Q9P035] 5.74 7.17 1.43 2.70 2.97E-05 3.82E-04 1.50E-09 2.78E-08 2.33 2 hsa-miR-206,hsa-miR-24, Transmembrane protein 161B [Source:UniProtKB/Swiss- TMEM161B ENSG00000164180 Prot;Acc:Q8NDZ6] 6.84 8.27 1.43 2.70 4.71E-05 5.57E-04 2.86E-06 2.38E-05 1.43 1 hsa-miR-24, Sorcin (22 kDa protein)(CP-22)(V19) [Source:UniProtKB/Swiss- SRI ENSG00000075142 Prot;Acc:P30626] 7.65 9.08 1.44 2.71 4.09E-05 4.95E-04 4.23E-09 6.93E-08 1.92 2 hsa-miR-18a,hsa-miR-24, Heterogeneous nuclear ribonucleoprotein F (hnRNP F)(Nucleolin- like protein mcs94-1) [Contains Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] HNRNPF ENSG00000169813 [Source:UniProtKB/Swiss-Prot;Acc:P52597] 7.42 8.85 1.44 2.71 3.18E-06 6.35E-05 1.73E-10 4.15E-09 1.86 3 hsa-miR-19a,hsa-miR-27a,hsa-miR-29b, Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter)(ASCT1)(SATT)(Solute carrier family 1 member 4) SLC1A4 ENSG00000115902 [Source:UniProtKB/Swiss-Prot;Acc:P43007] 5.39 6.83 1.44 2.71 6.51E-08 2.68E-06 3.99E-11 1.15E-09 1.44 2 hsa-miR-132,hsa-miR-21, Helicase-like transcription factor (EC 3.6.1.-)(SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 3)(Sucrose nonfermenting protein 2-like 3)(DNA-binding HLTF ENSG00000071794 protein/plasminogen activator inhibitor 1 regulator)(HIP116) 5.38 6.82 1.44 2.71 2.22E-04 1.99E-03 3.02E-06 2.51E-05 1.46 3 hsa-miR-155,hsa-miR-222,hsa-miR-7, UPF0557 protein C10orf119 [Source:UniProtKB/Swiss- C10orf119 ENSG00000197771 Prot;Acc:Q9BTE3] 7.24 8.68 1.44 2.72 1.97E-05 2.75E-04 4.25E-09 6.96E-08 1.82 1 hsa-miR-29b, Coiled-coil domain-containing protein 64A [Source:UniProtKB/Swiss- CCDC64 ENSG00000135127 Prot;Acc:Q6ZP65] 5.86 7.30 1.44 2.72 1.19E-06 2.84E-05 1.91E-08 2.68E-07 1.44 3 hsa-miR-218,hsa-miR-222,hsa-miR-24, Egl nine homolog 1 (EC 1.14.11.-)(Hypoxia-inducible factor prolyl hydroxylase 2)(HIF-prolyl hydroxylase 2)(HIF-PH2)(HPH-2)(Prolyl hydroxylase domain-containing protein 2)(PHD2)(SM-20) EGLN1 ENSG00000135766 [Source:UniProtKB/Swiss-Prot;Acc:Q9GZT9] 6.32 7.77 1.45 2.72 1.59E-04 1.52E-03 8.87E-05 5.25E-04 1.45 2 hsa-miR-200b,hsa-miR-21, Serpin H1 Precursor (Collagen-binding protein)(Colligin)(47 kDa heat shock protein)(Rheumatoid arthritis-related antigen RA- A47)(Arsenic-transactivated protein 3)(AsTP3)(Cell proliferation- SERPINH1 ENSG00000149257 inducing gene 14 protein) [Source:UniProtKB/Swiss- 6.07 7.52 1.45 2.72 1.27E-07 4.59E-06 5.55E-10 1.16E-08 1.45 2 hsa-miR-24,hsa-miR-29b, Lysosomal-trafficking regulator (Beige homolog) LYST ENSG00000143669 [Source:UniProtKB/Swiss-Prot;Acc:Q99698] 5.93 7.38 1.45 2.73 1.48E-04 1.43E-03 1.06E-05 7.79E-05 1.45 2 hsa-miR-221,hsa-miR-93, T-cell-specific surface glycoprotein CD28 Precursor (TP44)(CD28 CD28 ENSG00000178562 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P10747] 7.19 8.64 1.45 2.73 1.02E-04 1.05E-03 6.63E-05 4.05E-04 1.45 5 hsa-miR-155,hsa-miR-24,hsa-miR-27b,hsa-miR-424,hsa-miR-7, High affinity copper uptake protein 1 (Copper transporter 1)(hCTR1)(Solute carrier family 31 member 1) SLC31A1 ENSG00000136868 [Source:UniProtKB/Swiss-Prot;Acc:O15431] 5.12 6.57 1.45 2.74 1.88E-07 6.33E-06 8.10E-14 5.16E-12 2.08 1 hsa-miR-132, Basic leucine zipper and W2 domain-containing protein 1 (Protein BZW1 ENSG00000082153 Orf) [Source:UniProtKB/Swiss-Prot;Acc:Q7L1Q6] 8.39 9.84 1.45 2.74 3.25E-05 4.11E-04 4.63E-08 5.96E-07 1.62 1 hsa-let-7f, Interferon-alpha/beta receptor alpha chain Precursor (IFN-alpha- IFNAR1 ENSG00000142166 REC) [Source:UniProtKB/Swiss-Prot;Acc:P17181] 5.82 7.27 1.45 2.74 3.81E-04 3.09E-03 4.99E-05 3.15E-04 1.45 2 hsa-miR-155,hsa-miR-7,

V-type proton ATPase subunit C 1 (V-ATPase subunit C 1)(Vacuolar ATP6V1C1 ENSG00000155097 proton pump subunit C 1) [Source:UniProtKB/Swiss-Prot;Acc:P21283] 5.91 7.36 1.46 2.74 6.09E-04 4.54E-03 6.00E-07 5.85E-06 2.03 2 hsa-miR-155,hsa-miR-21, Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-)(ATP-dependent SKIV2L2 ENSG00000039123 helicase SKIV2L2) [Source:UniProtKB/Swiss-Prot;Acc:P42285] 6.97 8.43 1.46 2.75 2.10E-04 1.90E-03 6.53E-08 8.14E-07 2.00 1 hsa-miR-155, STX6 ENSG00000135823 Syntaxin-6 [Source:UniProtKB/Swiss-Prot;Acc:O43752] 5.84 7.30 1.46 2.75 7.82E-06 1.30E-04 6.39E-07 6.19E-06 1.49 5 hsa-miR-155,hsa-miR-221,hsa-miR-24,hsa-miR-27a,hsa-miR-7, Origin recognition complex subunit 5 [Source:UniProtKB/Swiss- ORC5L ENSG00000164815 Prot;Acc:O43913] 5.58 7.04 1.46 2.76 6.08E-04 4.54E-03 5.87E-07 5.73E-06 2.00 2 hsa-miR-218,hsa-miR-27a, stress-induced-phosphoprotein 1 (STIP1), mRNA [Source:RefSeq STIP1 ENSG00000225536 DNA;Acc:NM_006819] 5.63 7.09 1.46 2.76 2.52E-09 1.86E-07 4.76E-13 2.37E-11 2.02 1 hsa-miR-7, Histone deacetylase 2 (HD2)(EC 3.5.1.98) [Source:UniProtKB/Swiss- HDAC2 ENSG00000196591 Prot;Acc:Q92769] 5.78 7.25 1.46 2.76 8.27E-06 1.36E-04 5.15E-11 1.45E-09 2.20 2 hsa-miR-155,hsa-miR-21, V-type proton ATPase catalytic subunit A (V-ATPase subunit A)(EC 3.6.3.14)(Vacuolar proton pump subunit alpha)(V-ATPase 69 kDa subunit)(Vacuolar ATPase isoform VA68) [Source:UniProtKB/Swiss- ATP6V1A ENSG00000114573 Prot;Acc:P38606] 6.03 7.50 1.47 2.77 7.58E-07 1.95E-05 1.86E-09 3.36E-08 1.91 2 hsa-miR-27a,hsa-miR-365, Importin-11 (Imp11)(Ran-binding protein 11)(RanBP11) IPO11 ENSG00000086200 [Source:UniProtKB/Swiss-Prot;Acc:Q9UI26] 4.83 6.30 1.47 2.77 7.88E-05 8.48E-04 3.67E-10 8.11E-09 2.42 1 hsa-miR-7, M-phase phosphoprotein 9 [Source:UniProtKB/Swiss- MPHOSPH9 ENSG00000051825 Prot;Acc:Q99550] 5.77 7.25 1.47 2.78 2.84E-04 2.43E-03 1.30E-05 9.37E-05 1.47 2 hsa-miR-155,hsa-miR-19a, Armadillo repeat-containing X-linked protein 3 (Protein ALEX3)(ARM protein lost in epithelial cancers on chromosome X 3) ARMCX3 ENSG00000102401 [Source:UniProtKB/Swiss-Prot;Acc:Q9UH62] 6.28 7.76 1.48 2.78 1.42E-09 1.17E-07 9.44E-14 5.89E-12 1.48 2 hsa-miR-21,hsa-miR-365, Mediator of RNA polymerase II transcription subunit 8 (Mediator complex subunit 8)(Activator-recruited cofactor 32 kDa MED8 ENSG00000159479 component)(ARC32) [Source:UniProtKB/Swiss-Prot;Acc:Q96G25] 6.30 7.77 1.48 2.78 1.55E-06 3.53E-05 7.78E-08 9.50E-07 1.59 1 hsa-miR-18a, RuvB-like 2 (EC 3.6.1.-)(48 kDa TATA box-binding protein-interacting protein)(48 kDa TBP-interacting protein)(TIP49b)(Repressing pontin 52)(Reptin 52)(51 kDa erythrocyte cytosolic protein)(ECP-51)(TIP60- RUVBL2 ENSG00000183207 associated protein 54-beta)(TAP54-beta)(INO80 comple 6.15 7.63 1.48 2.78 8.12E-08 3.17E-06 6.01E-14 3.96E-12 1.96 1 hsa-miR-27a, Leucine-rich repeat-containing protein KIAA1731 KIAA1731 ENSG00000166004 [Source:UniProtKB/Swiss-Prot;Acc:Q9C0D2] 5.01 6.48 1.48 2.79 2.58E-05 3.40E-04 8.71E-07 8.16E-06 1.48 2 hsa-miR-155,hsa-miR-222,

Acylphosphatase-1 (EC 3.6.1.7)(Acylphosphate phosphohydrolase 1)(Acylphosphatase, organ-common type isozyme)(Acylphosphatase, ACYP1 ENSG00000119640 erythrocyte isozyme) [Source:UniProtKB/Swiss-Prot;Acc:P07311] 6.60 8.08 1.48 2.79 6.16E-07 1.65E-05 4.33E-11 1.24E-09 1.77 1 hsa-miR-155, Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1)(GPI-anchored membrane protein 1)(GPI-anchored protein p137)(GPI-p137)(p137GPI)(Cell cycle-associated protein 1)(Membrane component chromosome 11 surface marker 1) CAPRIN1 ENSG00000135387 [Source:UniProtKB/ 7.25 8.74 1.49 2.80 1.31E-05 1.96E-04 8.55E-10 1.70E-08 1.89 4 hsa-miR-132,hsa-miR-19a,hsa-miR-222,hsa-miR-7, Thioredoxin domain-containing protein 5 Precursor (Thioredoxin-like protein p46)(Endoplasmic reticulum protein ERp46) TXNDC5 ENSG00000188428 [Source:UniProtKB/Swiss-Prot;Acc:Q8NBS9] 5.96 7.45 1.49 2.80 5.59E-07 1.52E-05 1.35E-11 4.41E-10 1.89 2 hsa-miR-218,hsa-miR-7, Transcription factor Dp-1 (E2F dimerization partner 1)(DRTF1- TFDP1 ENSG00000198176 polypeptide 1)(DRTF1) [Source:UniProtKB/Swiss-Prot;Acc:Q14186] 6.15 7.64 1.49 2.80 5.28E-09 3.47E-07 2.71E-15 2.65E-13 2.05 1 hsa-miR-21, Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene)(Rho guanine nucleotide exchange factor 8) NET1 ENSG00000173848 [Source:UniProtKB/Swiss-Prot;Acc:Q7Z628] 5.60 7.09 1.49 2.81 3.52E-06 6.86E-05 2.45E-09 4.29E-08 1.52 4 hsa-miR-132,hsa-miR-206,hsa-miR-221,hsa-miR-24, Dynactin subunit 5 (Dynactin subunit p25) [Source:UniProtKB/Swiss- DCTN5 ENSG00000166847 Prot;Acc:Q9BTE1] 7.07 8.56 1.49 2.81 4.07E-06 7.67E-05 1.01E-09 1.96E-08 1.50 1 hsa-miR-18a, Glia maturation factor beta (GMF-beta) [Source:UniProtKB/Swiss- GMFB ENSG00000197045 Prot;Acc:P60983] 6.50 8.00 1.49 2.81 6.82E-05 7.55E-04 8.87E-09 1.35E-07 1.99 3 hsa-miR-132,hsa-miR-19a,hsa-miR-221, Signal recognition particle 72 kDa protein (SRP72) SRP72 ENSG00000174780 [Source:UniProtKB/Swiss-Prot;Acc:O76094] 7.08 8.58 1.49 2.82 8.49E-05 9.00E-04 5.49E-07 5.41E-06 1.69 1 hsa-miR-218, L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.-)(4'-phosphopantetheinyl transferase)(Alpha- aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase)(AASD-PPT)(LYS5 ortholog) [Source:UniProtKB/Swiss- AASDHPPT ENSG00000149313 Prot; 6.38 7.88 1.50 2.82 4.12E-05 4.97E-04 2.46E-08 3.38E-07 1.82 1 hsa-miR-21, CCR4-NOT transcription complex subunit 1 (Negative regulator of transcription subunit 1 homolog)(NOT1H)(hNOT1)(CCR4- CNOT1 ENSG00000125107 associated factor 1) [Source:UniProtKB/Swiss-Prot;Acc:A5YKK6] 7.61 9.11 1.50 2.82 2.07E-05 2.86E-04 5.15E-07 5.11E-06 1.50 1 hsa-miR-27a, Mitochondrial import inner membrane translocase subunit Tim13 TIMM13 ENSG00000099800 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5L4] 6.12 7.62 1.50 2.82 3.09E-05 3.95E-04 1.36E-10 3.38E-09 2.40 1 hsa-miR-24, Splicing factor 3A subunit 3 (Spliceosome-associated protein SF3A3 ENSG00000183431 61)(SAP 61)(SF3a60) [Source:UniProtKB/Swiss-Prot;Acc:Q12874] 6.13 7.63 1.50 2.82 6.37E-05 7.15E-04 5.38E-08 6.84E-07 2.00 1 hsa-miR-221, NMDA receptor-regulated protein 2 [Source:UniProtKB/Swiss- NARG2 ENSG00000128915 Prot;Acc:Q659A1] 6.18 7.68 1.50 2.82 1.02E-03 6.88E-03 3.13E-05 2.06E-04 1.64 2 hsa-miR-365,hsa-miR-7, Tumor protein D52 (Protein N8) [Source:UniProtKB/Swiss- TPD52 ENSG00000076554 Prot;Acc:P55327] 5.69 7.19 1.50 2.83 1.01E-05 1.60E-04 3.42E-08 4.52E-07 1.75 3 hsa-miR-155,hsa-miR-18a,hsa-miR-218, Xaa-Pro aminopeptidase 1 (EC 3.4.11.9)(X-Pro aminopeptidase 1)(X- prolyl aminopeptidase 1, soluble)(Cytosolic aminopeptidase P)(Soluble aminopeptidase P)(sAmp)(Aminoacylproline XPNPEP1 ENSG00000108039 aminopeptidase) [Source:UniProtKB/Swiss-Prot;Acc:Q9NQW7] 6.56 8.06 1.50 2.83 2.63E-08 1.28E-06 2.66E-12 1.05E-10 1.75 1 hsa-miR-18a, Transmembrane protein 14C [Source:UniProtKB/Swiss- TMEM14C ENSG00000111843 Prot;Acc:Q9P0S9] 6.97 8.47 1.50 2.83 2.06E-05 2.86E-04 2.13E-07 2.33E-06 1.65 1 hsa-miR-7, Ras-related protein Rab-7a [Source:UniProtKB/Swiss- RAB7A ENSG00000075785 Prot;Acc:P51149] 7.70 9.21 1.50 2.83 3.44E-04 2.85E-03 5.50E-07 5.42E-06 2.05 3 hsa-miR-200b,hsa-miR-210,hsa-miR-7,

Disintegrin and metalloproteinase domain-containing protein 17 Precursor (ADAM 17)(EC 3.4.24.86)(TNF-alpha-converting enzyme)(TNF-alpha convertase)(Snake venom-like protease)(CD156b ADAM17 ENSG00000151694 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P78536] 5.73 7.23 1.50 2.84 4.65E-05 5.51E-04 4.03E-06 3.25E-05 1.50 1 hsa-miR-221, Male-enhanced antigen 1 (MEA-1) [Source:UniProtKB/Swiss- MEA1 ENSG00000124733 Prot;Acc:Q16626] 6.62 8.13 1.50 2.84 1.27E-05 1.93E-04 8.56E-09 1.31E-07 1.81 1 hsa-miR-18a, Integrator complex subunit 6 (Int6)(Protein deleted in cancer 1)(DICE1)(Protein DDX26)(DBI-1) [Source:UniProtKB/Swiss- INTS6 ENSG00000102786 Prot;Acc:Q9UL03] 6.61 8.11 1.50 2.84 2.37E-05 3.19E-04 3.41E-06 2.79E-05 1.50 3 hsa-miR-200b,hsa-miR-218,hsa-miR-7, Coiled-coil domain-containing protein 25 [Source:UniProtKB/Swiss- CCDC25 ENSG00000147419 Prot;Acc:Q86WR0] 6.17 7.68 1.51 2.84 1.22E-05 1.86E-04 8.57E-09 1.31E-07 1.58 2 hsa-miR-424,hsa-miR-7, G2/mitotic-specific cyclin-F [Source:UniProtKB/Swiss- CCNF ENSG00000162063 Prot;Acc:P41002] 5.56 7.07 1.51 2.84 1.04E-11 2.24E-09 1.67E-14 1.28E-12 1.51 1 hsa-miR-7, Probable saccharopine dehydrogenase (EC 1.5.1.9) SCCPDH ENSG00000143653 [Source:UniProtKB/Swiss-Prot;Acc:Q8NBX0] 5.82 7.33 1.51 2.84 7.12E-09 4.39E-07 1.75E-13 1.02E-11 1.85 1 hsa-miR-424, Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta)(MAT II beta)(Methionine adenosyltransferase 2 beta subunit)(DTDP-4-keto-6-deoxy-D-glucose MAT2B ENSG00000038274 4-reductase) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZL9] 7.23 8.74 1.51 2.85 1.94E-04 1.78E-03 1.42E-05 1.01E-04 1.51 1 hsa-miR-20b, Basic leucine zipper and W2 domain-containing protein 2 BZW2 ENSG00000136261 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y6E2] 5.97 7.48 1.51 2.85 1.68E-04 1.59E-03 1.00E-08 1.50E-07 2.25 1 hsa-miR-218, Acylglycerol kinase, mitochondrial Precursor (hAGK)(EC 2.7.1.94)(EC 2.7.1.107)(Multiple substrate lipid kinase)(Multi- substrate lipid kinase)(MuLK)(HsMuLK) [Source:UniProtKB/Swiss- AGK ENSG00000006530 Prot;Acc:Q53H12] 6.06 7.57 1.51 2.85 2.58E-05 3.40E-04 1.30E-08 1.89E-07 1.87 2 hsa-miR-132,hsa-miR-7, 28S ribosomal protein S14, mitochondrial (S14mt)(MRP-S14) MRPS14 ENSG00000120333 [Source:UniProtKB/Swiss-Prot;Acc:O60783] 5.54 7.05 1.51 2.85 1.10E-05 1.71E-04 1.11E-08 1.64E-07 1.64 2 hsa-miR-155,hsa-miR-27a, SNARE-associated protein Snapin (Synaptosomal-associated protein 25-binding protein)(SNAP-associated protein) SNAPIN ENSG00000143553 [Source:UniProtKB/Swiss-Prot;Acc:O95295] 5.81 7.32 1.51 2.85 8.38E-05 8.90E-04 1.10E-05 8.05E-05 1.51 1 hsa-miR-218, Exportin-1 (Exp1)(Chromosome region maintenance 1 protein XPO1 ENSG00000082898 homolog) [Source:UniProtKB/Swiss-Prot;Acc:O14980] 6.67 8.18 1.51 2.85 2.72E-04 2.34E-03 2.18E-06 1.87E-05 1.88 1 hsa-miR-27b, RING finger protein 145 [Source:UniProtKB/Swiss- RNF145 ENSG00000145860 Prot;Acc:Q96MT1] 6.69 8.21 1.52 2.86 4.18E-07 1.19E-05 1.75E-09 3.18E-08 1.83 2 hsa-miR-18a,hsa-miR-19a,

Serine/threonine-protein kinase RIO3 (RIO kinase 3)(EC RIOK3 ENSG00000101782 2.7.11.1)(sudD homolog) [Source:UniProtKB/Swiss-Prot;Acc:O14730] 7.11 8.62 1.52 2.86 3.88E-05 4.72E-04 1.37E-05 9.83E-05 1.52 1 hsa-let-7f, Probable tRNA pseudouridine synthase 1 (EC 5.4.99.-) TRUB1 ENSG00000165832 [Source:UniProtKB/Swiss-Prot;Acc:Q8WWH5] 5.94 7.46 1.52 2.87 1.29E-05 1.94E-04 1.72E-09 3.13E-08 1.73 3 hsa-miR-155,hsa-miR-18a,hsa-miR-7, Origin recognition complex subunit 2 [Source:UniProtKB/Swiss- ORC2L ENSG00000115942 Prot;Acc:Q13416] 5.97 7.49 1.52 2.87 2.14E-04 1.93E-03 4.01E-07 4.07E-06 1.84 1 hsa-miR-218, Monocyte to macrophage differentiation protein (Progestin and adipoQ receptor family member XI) [Source:UniProtKB/Swiss- MMD ENSG00000108960 Prot;Acc:Q15546] 5.53 7.05 1.52 2.87 3.21E-05 4.07E-04 1.59E-07 1.80E-06 1.55 4 hsa-miR-155,hsa-miR-19a,hsa-miR-200b,hsa-miR-27a, PX domain-containing protein kinase-like protein (Modulator of Na,K- PXK ENSG00000168297 ATPase)(MONaKA) [Source:UniProtKB/Swiss-Prot;Acc:Q7Z7A4] 6.18 7.71 1.53 2.88 5.78E-06 1.01E-04 1.19E-07 1.39E-06 1.53 1 hsa-miR-24, Mitochondrial thiamine pyrophosphate carrier (Solute carrier family 25 member 19)(Mitochondrial uncoupling protein 1) SLC25A19 ENSG00000125454 [Source:UniProtKB/Swiss-Prot;Acc:Q9HC21] 5.44 6.97 1.53 2.88 3.44E-09 2.42E-07 2.49E-14 1.82E-12 2.14 1 hsa-miR-7, Uncharacterized protein C18orf54 Precursor C18orf54 ENSG00000166845 [Source:UniProtKB/Swiss-Prot;Acc:Q8IYD9] 5.03 6.55 1.53 2.88 1.35E-05 2.01E-04 1.18E-05 8.62E-05 1.53 2 hsa-miR-155,hsa-miR-7, Cytochrome c oxidase subunit 7B, mitochondrial Precursor (Cytochrome c oxidase polypeptide VIIb) [Source:UniProtKB/Swiss- COX7B ENSG00000131174 Prot;Acc:P24311] 6.54 8.07 1.53 2.88 1.07E-03 7.17E-03 3.45E-05 2.25E-04 2.20 1 hsa-miR-365, Pseudouridylate synthase 7 homolog-like protein (EC 5.4.99.-) PUS7L ENSG00000129317 [Source:UniProtKB/Swiss-Prot;Acc:Q9H0K6] 5.16 6.69 1.53 2.89 3.85E-04 3.12E-03 3.24E-06 2.67E-05 1.81 1 hsa-miR-155, Voltage-dependent anion-selective channel protein 2 (VDAC- 2)(hVDAC2)(Outer mitochondrial membrane protein porin 2) VDAC2 ENSG00000165637 [Source:UniProtKB/Swiss-Prot;Acc:P45880] 7.36 8.88 1.53 2.89 2.30E-06 4.85E-05 3.39E-09 5.72E-08 1.57 1 hsa-miR-132, Histone RNA hairpin-binding protein (Histone stem-loop-binding SLBP ENSG00000163950 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q14493] 6.46 7.99 1.53 2.89 4.00E-04 3.22E-03 2.59E-08 3.53E-07 2.52 2 hsa-miR-132,hsa-miR-7, Retinoblastoma-like protein 1 (PRB1)(107 kDa retinoblastoma- associated protein)(p107) [Source:UniProtKB/Swiss- RBL1 ENSG00000080839 Prot;Acc:P28749] 5.77 7.30 1.53 2.89 2.45E-04 2.15E-03 2.26E-06 1.94E-05 1.73 1 hsa-miR-24, Lysine-rich coiled-coil protein 1 (Cryptogenic hepatitis-binding protein KRCC1 ENSG00000172086 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9NPI7] 2.93 4.46 1.53 2.89 1.13E-03 7.49E-03 2.09E-03 8.74E-03 1.53 1 hsa-miR-155, 26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit S14)(p31) [Source:UniProtKB/Swiss- PSMD8 ENSG00000099341 Prot;Acc:P48556] 7.73 9.26 1.53 2.89 4.57E-06 8.42E-05 1.02E-09 1.97E-08 2.04 2 hsa-miR-132,hsa-miR-7,

CCNE1 ENSG00000105173 G1/S-specific cyclin-E1 [Source:UniProtKB/Swiss-Prot;Acc:P24864] 5.05 6.58 1.53 2.89 1.35E-08 7.50E-07 4.32E-16 5.28E-14 3.00 1 hsa-miR-7, Transmembrane protein C9orf46 [Source:UniProtKB/Swiss- C9orf46 ENSG00000107020 Prot;Acc:Q9HBL7] 5.76 7.29 1.53 2.90 1.02E-04 1.05E-03 4.41E-07 4.44E-06 2.00 1 hsa-miR-218, RING finger and WD repeat domain-containing protein 3 (RING RFWD3 ENSG00000168411 finger protein 201) [Source:UniProtKB/Swiss-Prot;Acc:Q6PCD5] 5.55 7.09 1.54 2.90 1.89E-07 6.35E-06 2.22E-11 6.84E-10 1.73 1 hsa-miR-155, FAM18B ENSG00000171928 Protein FAM18B [Source:UniProtKB/Swiss-Prot;Acc:Q9NYZ1] 7.07 8.60 1.54 2.90 3.12E-05 3.99E-04 2.53E-07 2.71E-06 1.54 1 hsa-miR-155, DnaJ homolog subfamily C member 15 (Methylation-controlled J protein)(MCJ)(Cell growth-inhibiting gene 22 protein) DNAJC15 ENSG00000120675 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5T4] 5.55 7.09 1.54 2.90 2.09E-04 1.89E-03 6.73E-06 5.16E-05 1.57 2 hsa-miR-155,hsa-miR-7, UPF0469 protein KIAA0907 [Source:UniProtKB/Swiss- KIAA0907 ENSG00000132680 Prot;Acc:Q7Z7F0] 5.98 7.52 1.54 2.90 3.11E-06 6.23E-05 2.08E-08 2.90E-07 1.54 2 hsa-miR-19a,hsa-miR-365, Coiled-coil domain-containing protein 55 [Source:UniProtKB/Swiss- CCDC55 ENSG00000126653 Prot;Acc:Q9H0G5] 5.25 6.79 1.54 2.91 3.42E-06 6.73E-05 1.18E-06 1.08E-05 1.54 1 hsa-miR-218, Zinc transporter ZIP9 (Zrt- and Irt-like protein 9)(ZIP-9)(Solute SLC39A9 ENSG00000029364 carrier family 39 member 9) [Source:UniProtKB/Swiss- 6.17 7.70 1.54 2.91 7.46E-06 1.25E-04 4.62E-09 7.49E-08 1.59 1 hsa-miR-222, Cleavage stimulation factor 50 kDa subunit (CSTF 50 kDa subunit)(CF-1 50 kDa subunit)(CstF-50) [Source:UniProtKB/Swiss- CSTF1 ENSG00000101138 Prot;Acc:Q05048] 6.07 7.61 1.54 2.91 2.06E-06 4.43E-05 9.41E-09 1.43E-07 1.54 1 hsa-miR-155, CDGSH iron sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein)(MitoNEET-related 1 CISD2 ENSG00000145354 protein)(Miner1) [Source:UniProtKB/Swiss-Prot;Acc:Q8N5K1] 6.73 8.27 1.54 2.91 1.20E-05 1.84E-04 4.52E-08 5.83E-07 1.82 1 hsa-miR-7, Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67)(Phosphatidylinositol 4-kinase type II-beta)(PI4KII-BETA) PI4K2B ENSG00000038210 [Source:UniProtKB/Swiss-Prot;Acc:Q8TCG2] 5.94 7.48 1.54 2.91 8.87E-06 1.44E-04 1.09E-09 2.08E-08 2.04 1 hsa-miR-7, STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20- related kinase)(EC 2.7.11.1)(Serine/threonine-protein kinase STK39 ENSG00000198648 39)(DCHT) [Source:UniProtKB/Swiss-Prot;Acc:Q9UEW8] 7.07 8.61 1.54 2.91 7.25E-05 7.95E-04 1.36E-07 1.56E-06 1.77 3 hsa-miR-132,hsa-miR-19a,hsa-miR-27a, Eukaryotic translation initiation factor 5B (eIF-5B)(Translation EIF5B ENSG00000158417 initiation factor IF-2) [Source:UniProtKB/Swiss-Prot;Acc:O60841] 5.39 6.93 1.54 2.91 1.01E-05 1.60E-04 4.45E-10 9.62E-09 2.30 1 hsa-miR-200b, Uncharacterized protein C16orf45 [Source:UniProtKB/Swiss- C16orf45 ENSG00000166780 Prot;Acc:Q96MC5] 5.67 7.21 1.54 2.92 9.54E-09 5.57E-07 3.15E-11 9.31E-10 1.54 1 hsa-miR-221, ATP-dependent RNA helicase DDX18 (EC 3.6.1.-)(DEAD box protein 18)(Myc-regulated DEAD box protein)(MrDb) DDX18 ENSG00000088205 [Source:UniProtKB/Swiss-Prot;Acc:Q9NVP1] 7.04 8.58 1.54 2.92 6.27E-05 7.06E-04 1.91E-08 2.68E-07 2.09 2 hsa-miR-222,hsa-miR-7, Uncharacterized protein C3orf23 [Source:UniProtKB/Swiss- C3orf23 ENSG00000179152 Prot;Acc:Q8N3R3] 5.44 6.99 1.55 2.92 3.60E-06 6.99E-05 1.91E-08 2.68E-07 1.55 2 hsa-miR-155,hsa-miR-200b, Coiled-coil domain-containing protein 82 [Source:UniProtKB/Swiss- CCDC82 ENSG00000149231 Prot;Acc:Q8N4S0] 6.16 7.70 1.55 2.92 1.76E-04 1.65E-03 2.88E-05 1.91E-04 1.55 1 hsa-miR-155, Cation transport regulator-like protein 1 [Source:UniProtKB/Swiss- CHAC1 ENSG00000128965 Prot;Acc:Q9BUX1] 5.72 7.27 1.55 2.92 1.06E-07 3.95E-06 1.71E-11 5.42E-10 1.65 2 hsa-miR-132,hsa-miR-24, Transmembrane protein 49 (Vacuole membrane protein 1) TMEM49 ENSG00000062716 [Source:UniProtKB/Swiss-Prot;Acc:Q96GC9] 7.68 9.23 1.55 2.93 5.25E-05 6.08E-04 4.70E-08 6.03E-07 1.67 1 hsa-miR-19a, E3 ubiquitin-protein ligase UHRF1 (EC 6.3.2.-)(Ubiquitin-like PHD and RING finger domain-containing protein 1)(Ubiquitin-like- containing PHD and RING finger domains protein 1)(Inverted CCAAT UHRF1 ENSG00000034063 box-binding protein of 90 kDa)(Transcription factor ICBP90)(Nucl 5.11 6.66 1.55 2.93 6.20E-11 9.45E-09 3.36E-19 1.24E-16 2.34 1 hsa-miR-7, Glucose 1,6-bisphosphate synthase (EC 2.7.1.106)(Phosphoglucomutase-2-like 1)(PMMLP) hsa-miR-130b,hsa-miR-132,hsa-miR-19a,hsa-miR-200b,hsa-miR-218,hsa-miR- PGM2L1 ENSG00000165434 [Source:UniProtKB/Swiss-Prot;Acc:Q6PCE3] 5.33 6.88 1.55 2.93 9.65E-06 1.53E-04 2.78E-06 2.33E-05 1.55 8 222,hsa-miR-27a,hsa-miR-7, Translocon-associated protein subunit gamma (TRAP- gamma)(Signal sequence receptor subunit gamma)(SSR-gamma) SSR3 ENSG00000114850 [Source:UniProtKB/Swiss-Prot;Acc:Q9UNL2] 6.30 7.85 1.55 2.93 6.70E-05 7.45E-04 8.27E-08 1.00E-06 1.88 2 hsa-miR-200b,hsa-miR-218, RING finger protein 185 [Source:UniProtKB/Swiss- RNF185 ENSG00000138942 Prot;Acc:Q96GF1] 5.73 7.28 1.55 2.93 2.61E-05 3.43E-04 1.20E-07 1.41E-06 1.55 2 hsa-miR-18a,hsa-miR-7, THAP domain-containing protein 6 [Source:UniProtKB/Swiss- THAP6 ENSG00000174796 Prot;Acc:Q8TBB0] 4.99 6.54 1.55 2.93 5.18E-05 6.02E-04 4.44E-08 5.72E-07 1.75 3 hsa-miR-155,hsa-miR-21,hsa-miR-7, CCR4-NOT transcription complex subunit 10 CNOT10 ENSG00000182973 [Source:UniProtKB/Swiss-Prot;Acc:Q9H9A5] 5.79 7.34 1.55 2.93 2.55E-05 3.37E-04 2.23E-07 2.43E-06 1.57 1 hsa-miR-132, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.1.-)(ATP- dependent helicase 1)(hHEL1) [Source:UniProtKB/Swiss- SMARCAD1 ENSG00000163104 Prot;Acc:Q9H4L7] 5.60 7.15 1.55 2.93 2.90E-04 2.47E-03 1.82E-06 1.59E-05 1.90 2 hsa-let-7f,hsa-miR-155, Polycomb protein SUZ12 (Suppressor of zeste 12 protein homolog)(Joined to JAZF1 protein)(Chromatin precipitated E2F target 9 protein)(ChET 9 protein) [Source:UniProtKB/Swiss- SUZ12 ENSG00000178691 Prot;Acc:Q15022] 7.06 8.62 1.55 2.94 3.96E-05 4.81E-04 1.42E-08 2.06E-07 1.93 5 hsa-miR-155,hsa-miR-19a,hsa-miR-200b,hsa-miR-210,hsa-miR-27a, Sperm-associated antigen 1 (Infertility-related sperm protein Spag- SPAG1 ENSG00000104450 1)(HSD-3.8) [Source:UniProtKB/Swiss-Prot;Acc:Q07617] 5.28 6.83 1.55 2.94 5.77E-10 5.69E-08 4.90E-15 4.52E-13 1.73 1 hsa-miR-7, Endonuclease domain-containing 1 protein Precursor (EC 3.1.30.-) ENDOD1 ENSG00000149218 [Source:UniProtKB/Swiss-Prot;Acc:O94919] 5.78 7.34 1.56 2.94 1.32E-05 1.98E-04 2.65E-08 3.60E-07 1.71 4 hsa-miR-18a,hsa-miR-19a,hsa-miR-200b,hsa-miR-21, Regulator of G-protein signaling 16 (RGS16)(Retinally abundant regulator of G-protein signaling)(RGS-R)(A28-RGS14P) RGS16 ENSG00000143333 [Source:UniProtKB/Swiss-Prot;Acc:O15492] 6.85 8.41 1.56 2.95 8.69E-09 5.16E-07 3.84E-17 6.70E-15 2.13 1 hsa-miR-7, FNTB ENSG00000125954 Protein Churchill [Source:UniProtKB/Swiss-Prot;Acc:Q8WUH1] 5.71 7.27 1.56 2.95 2.68E-06 5.50E-05 7.97E-08 9.71E-07 1.56 3 hsa-miR-200b,hsa-miR-24,hsa-miR-7, ELAV-like protein 1 (Hu-antigen R)(HuR) [Source:UniProtKB/Swiss- ELAVL1 ENSG00000066044 Prot;Acc:Q15717] 6.19 7.75 1.56 2.96 1.03E-04 1.06E-03 1.55E-09 2.88E-08 2.49 3 hsa-miR-19a,hsa-miR-424,hsa-miR-7, Motile sperm domain-containing protein 1 [Source:UniProtKB/Swiss- MOSPD1 ENSG00000101928 Prot;Acc:Q9UJG1] 4.95 6.51 1.56 2.96 1.26E-05 1.92E-04 6.51E-10 1.34E-08 2.00 3 hsa-miR-132,hsa-miR-218,hsa-miR-7, GSK3-beta interaction protein (GSKIP) [Source:UniProtKB/Swiss- C14orf129 ENSG00000100744 Prot;Acc:Q9P0R6] 5.47 7.04 1.57 2.96 2.37E-04 2.10E-03 1.37E-08 1.99E-07 2.33 2 hsa-miR-19a,hsa-miR-218, Ribosomal L1 domain-containing protein 1 (Cellular senescence- inhibited gene protein)(Protein PBK1)(CATX-11) RSL1D1 ENSG00000171490 [Source:UniProtKB/Swiss-Prot;Acc:O76021] 7.36 8.92 1.57 2.96 4.45E-05 5.30E-04 4.82E-07 4.82E-06 1.57 2 hsa-miR-155,hsa-miR-7, Elongation of very long chain fatty acids protein 6 (hELO2)(Fatty acyl- CoA elongase)(Long-chain fatty-acyl elongase) ELOVL6 ENSG00000170522 [Source:UniProtKB/Swiss-Prot;Acc:Q9H5J4] 4.52 6.09 1.57 2.97 2.59E-07 8.19E-06 8.53E-12 2.96E-10 2.29 2 hsa-miR-155,hsa-miR-210, U3 small nucleolar RNA-associated protein 15 homolog UTP15 ENSG00000164338 [Source:UniProtKB/Swiss-Prot;Acc:Q8TED0] 4.72 6.30 1.57 2.98 1.90E-05 2.67E-04 1.84E-11 5.79E-10 2.63 2 hsa-miR-18a,hsa-miR-21, General transcription factor IIH subunit 1 (General transcription factor IIH polypeptide 1)(TFIIH basal transcription factor complex p62 subunit)(Basic transcription factor 2 62 kDa subunit)(BTF2-p62) GTF2H1 ENSG00000110768 [Source:UniProtKB/Swiss-Prot;Acc:P32780] 5.24 6.82 1.58 2.98 4.11E-05 4.96E-04 1.36E-07 1.57E-06 1.83 1 hsa-miR-132, YEATS domain-containing protein 4 (Glioma-amplified sequence 41)(Gas41)(NuMA-binding protein 1)(NuBI-1)(NuBI1) YEATS4 ENSG00000127337 [Source:UniProtKB/Swiss-Prot;Acc:O95619] 6.94 8.52 1.58 2.98 2.66E-05 3.49E-04 1.24E-07 1.44E-06 1.58 1 hsa-miR-218, Structural maintenance of chromosomes protein 1A (SMC1alpha SMC1A ENSG00000072501 protein)(Sb1.8) [Source:UniProtKB/Swiss-Prot;Acc:Q14683] 5.80 7.38 1.58 2.98 8.05E-06 1.33E-04 1.71E-09 3.13E-08 1.89 6 hsa-miR-132,hsa-miR-135b,hsa-miR-18a,hsa-miR-21,hsa-miR-218,hsa-miR-7, TIP41-like protein (Putative MAPK-activating protein PM10) TIPRL ENSG00000143155 [Source:UniProtKB/Swiss-Prot;Acc:O75663] 6.27 7.85 1.58 2.99 2.44E-05 3.26E-04 2.29E-07 2.49E-06 1.63 1 hsa-miR-7, Growth hormone-inducible transmembrane protein (Dermal papilla- derived protein 2)(Transmembrane BAX inhibitor motif-containing GHITM ENSG00000165678 protein 5) [Source:UniProtKB/Swiss-Prot;Acc:Q9H3K2] 7.60 9.18 1.58 2.99 1.29E-05 1.94E-04 8.21E-09 1.26E-07 1.78 2 hsa-miR-155,hsa-miR-218, Probable DNA dC->dU-editing enzyme APOBEC-3B (EC 3.5.4.- )(Phorbolin-1-related protein)(Phorbolin-2/3) APOBEC3B ENSG00000179750 [Source:UniProtKB/Swiss-Prot;Acc:Q9UH17] 6.45 8.03 1.58 2.99 1.73E-08 9.10E-07 5.05E-11 1.42E-09 1.58 1 hsa-miR-7, Cell division cycle protein 27 homolog (CDC27Hs)(H-NUC) CDC27 ENSG00000004897 [Source:UniProtKB/Swiss-Prot;Acc:P30260] 6.58 8.16 1.58 2.99 1.34E-06 3.12E-05 2.82E-07 2.98E-06 1.58 3 hsa-miR-200b,hsa-miR-27a,hsa-miR-363, Oligonucleotide/oligosaccharide-binding fold-containing protein 2A (Single-stranded DNA-binding protein 2)(SSB2) OBFC2A ENSG00000173559 [Source:UniProtKB/Swiss-Prot;Acc:Q96AH0] 6.18 7.76 1.58 3.00 1.13E-06 2.71E-05 2.22E-09 3.93E-08 1.58 3 hsa-miR-132,hsa-miR-27a,hsa-miR-365, GTP-binding nuclear protein Ran (GTPase Ran)(Ras-related nuclear protein)(Ras-like protein TC4)(Androgen receptor-associated protein RAN ENSG00000132341 24) [Source:UniProtKB/Swiss-Prot;Acc:P62826] 8.56 10.15 1.58 3.00 8.11E-08 3.17E-06 7.43E-14 4.78E-12 1.78 1 hsa-miR-21, Importin-9 (Imp9)(Ran-binding protein 9)(RanbP9) IPO9 ENSG00000198700 [Source:UniProtKB/Swiss-Prot;Acc:Q96P70] 5.86 7.44 1.58 3.00 2.95E-05 3.79E-04 8.63E-10 1.71E-08 2.25 5 hsa-miR-155,hsa-miR-19a,hsa-miR-21,hsa-miR-29b,hsa-miR-7, Transmembrane protein 167A Precursor [Source:UniProtKB/Swiss- TMEM167A ENSG00000174695 Prot;Acc:Q8TBQ9] 7.47 9.05 1.59 3.00 7.83E-05 8.44E-04 2.38E-08 3.28E-07 1.98 1 hsa-miR-155, E3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-)(p53-binding protein Mdm2)(Oncoprotein Mdm2)(Double minute 2 protein)(Hdm2) MDM2 ENSG00000135679 [Source:UniProtKB/Swiss-Prot;Acc:Q00987] 5.98 7.57 1.59 3.00 7.69E-06 1.28E-04 1.10E-07 1.29E-06 1.73 1 hsa-miR-221, Transmembrane protein 97 (Protein MAC30) TMEM97 ENSG00000109084 [Source:UniProtKB/Swiss-Prot;Acc:Q5BJF2] 5.83 7.41 1.59 3.00 3.07E-08 1.44E-06 1.64E-13 9.60E-12 2.35 1 hsa-miR-7, Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15)(Ubiquitin thioesterase 14)(Ubiquitin-specific-processing protease 14)(Deubiquitinating enzyme 14) [Source:UniProtKB/Swiss- USP14 ENSG00000101557 Prot;Acc:P54578] 5.96 7.54 1.59 3.01 2.12E-05 2.91E-04 1.61E-08 2.30E-07 1.99 2 hsa-miR-155,hsa-miR-424, Histone demethylase JARID1B (EC 1.14.11.-)(Jumonji/ARID domain- containing protein 1B)(PLU-1)(Retinoblastoma-binding protein 2 homolog 1)(RBP2-H1)(Cancer/testis antigen 31)(CT31) JARID1B ENSG00000117139 [Source:UniProtKB/Swiss-Prot;Acc:Q9UGL1] 6.15 7.74 1.59 3.01 5.82E-06 1.02E-04 1.49E-06 1.33E-05 1.59 4 hsa-miR-155,hsa-miR-18a,hsa-miR-29b,hsa-miR-7, Peroxisomal membrane protein PMP34 (34 kDa peroxisomal membrane protein)(Solute carrier family 25 member 17) SLC25A17 ENSG00000100372 [Source:UniProtKB/Swiss-Prot;Acc:O43808] 5.25 6.84 1.59 3.01 1.09E-04 1.10E-03 5.29E-09 8.44E-08 2.43 1 hsa-miR-218, Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha)(Nuclear receptor subfamily 2 group B member 1) RXRA ENSG00000186350 [Source:UniProtKB/Swiss-Prot;Acc:P19793] 5.86 7.45 1.59 3.01 1.53E-07 5.34E-06 4.61E-06 3.68E-05 1.59 5 hsa-miR-130b,hsa-miR-155,hsa-miR-19a,hsa-miR-27a,hsa-miR-7, Glycosyltransferase-like domain-containing protein 1 (Mat-Xa) GTDC1 ENSG00000121964 [Source:UniProtKB/Swiss-Prot;Acc:Q4AE62] 5.63 7.22 1.59 3.01 1.42E-05 2.11E-04 1.01E-07 1.20E-06 1.62 2 hsa-miR-132,hsa-miR-24, Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2)(ARC16-2) [Source:UniProtKB/Swiss- ARPC5L ENSG00000136950 Prot;Acc:Q9BPX5] 6.10 7.69 1.59 3.01 2.28E-05 3.09E-04 1.81E-07 2.02E-06 2.11 1 hsa-miR-7, Transmembrane protein 68 [Source:UniProtKB/Swiss- TMEM68 ENSG00000167904 Prot;Acc:Q96MH6] 5.04 6.64 1.59 3.02 2.28E-05 3.09E-04 9.83E-08 1.17E-06 1.74 2 hsa-miR-21,hsa-miR-218, Jerky protein homolog-like (HHMJG) [Source:UniProtKB/Swiss- JRKL ENSG00000183340 Prot;Acc:Q9Y4A0] 5.69 7.29 1.60 3.03 3.10E-06 6.22E-05 1.20E-08 1.77E-07 1.66 1 hsa-miR-18a, Mitochondrial import inner membrane translocase subunit TIM44 TIMM44 ENSG00000104980 Precursor [Source:UniProtKB/Swiss-Prot;Acc:O43615] 6.01 7.61 1.60 3.03 2.50E-07 7.95E-06 6.34E-13 3.01E-11 1.87 1 hsa-miR-7, Protein slowmo homolog 2 [Source:UniProtKB/Swiss- SLMO2 ENSG00000101166 Prot;Acc:Q9Y3B1] 7.13 8.73 1.60 3.04 2.89E-06 5.85E-05 3.06E-09 5.24E-08 1.80 1 hsa-miR-222, RecQ-mediated genome instability protein 2 (hRMI2)(BLM- associated protein of 18 kDa)(BLAP18) [Source:UniProtKB/Swiss- C16orf75 ENSG00000175643 Prot;Acc:Q96E14] 6.97 8.57 1.60 3.04 3.75E-13 1.52E-10 1.63E-13 9.57E-12 1.60 1 hsa-miR-7, Zinc finger protein 395 (Papillomavirus-binding factor)(Papillomavirus regulatory factor 1)(PRF-1)(Huntington disease gene regulatory region-binding protein 2)(HDBP-2)(HD gene regulatory region- ZNF395 ENSG00000186918 binding protein 2)(HD-regulating factor 2)(HDRF-2) [Source:Un 6.83 8.44 1.60 3.04 4.86E-06 8.85E-05 2.13E-05 1.46E-04 1.60 4 hsa-miR-132,hsa-miR-200b,hsa-miR-24,hsa-miR-7, Protein PAT1 homolog 1 (PAT1-like protein 1) PATL1 ENSG00000166889 [Source:UniProtKB/Swiss-Prot;Acc:Q86TB9] 6.33 7.94 1.60 3.04 4.62E-06 8.49E-05 1.25E-07 1.46E-06 1.60 3 hsa-miR-18a,hsa-miR-19a,hsa-miR-7, Nuclear ubiquitous casein and cyclin-dependent kinases substrate NUCKS1 ENSG00000069275 (P1) [Source:UniProtKB/Swiss-Prot;Acc:Q9H1E3] 6.72 8.32 1.60 3.04 2.64E-05 3.48E-04 2.36E-07 2.55E-06 1.60 1 hsa-miR-135b, tRNA-splicing endonuclease subunit Sen15 (tRNA-intron endonuclease Sen15)(HsSen15) [Source:UniProtKB/Swiss- TSEN15 ENSG00000198860 Prot;Acc:Q8WW01] 5.30 6.91 1.61 3.05 2.61E-06 5.38E-05 1.60E-11 5.10E-10 2.36 1 hsa-miR-7, PHD finger protein 19 (Polycomb-like protein 3)(hPCL3) PHF19 ENSG00000119403 [Source:UniProtKB/Swiss-Prot;Acc:Q5T6S3] 6.67 8.28 1.61 3.05 1.35E-08 7.47E-07 5.10E-12 1.87E-10 1.61 3 hsa-miR-18a,hsa-miR-218,hsa-miR-7, Ethanolamine kinase 1 (EKI 1)(EC 2.7.1.82) [Source:UniProtKB/Swiss- ETNK1 ENSG00000139163 Prot;Acc:Q9HBU6] 6.40 8.01 1.61 3.06 1.51E-05 2.21E-04 5.39E-09 8.58E-08 1.76 4 hsa-miR-18a,hsa-miR-19a,hsa-miR-218,hsa-miR-24, Tribbles homolog 3 (TRB-3)(Neuronal cell death-inducible putative kinase)(p65-interacting inhibitor of NF-kappa-B)(SINK) TRIB3 ENSG00000101255 [Source:UniProtKB/Swiss-Prot;Acc:Q96RU7] 5.84 7.45 1.61 3.06 1.70E-08 8.99E-07 2.96E-13 1.57E-11 1.74 1 hsa-miR-24, Trafficking protein particle complex subunit 6B TRAPPC6B ENSG00000182400 [Source:UniProtKB/Swiss-Prot;Acc:Q86SZ2] 5.62 7.23 1.62 3.07 6.07E-05 6.86E-04 1.57E-07 1.78E-06 1.79 1 hsa-miR-7, MYO1D ENSG00000176658 Myosin-Id [Source:UniProtKB/Swiss-Prot;Acc:O94832] 5.29 6.91 1.62 3.07 3.45E-06 6.77E-05 3.69E-07 3.79E-06 1.62 1 hsa-miR-155, Double-strand-break repair protein rad21 homolog (hHR21)(Nuclear matrix protein 1)(NXP-1)(SCC1 homolog) [Source:UniProtKB/Swiss- RAD21 ENSG00000164754 Prot;Acc:O60216] 7.47 9.09 1.62 3.07 6.31E-05 7.10E-04 4.42E-06 3.54E-05 1.62 2 hsa-miR-155,hsa-miR-363, Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein)(140 kDa nucleolar phosphoprotein)(Nopp140)(Nucleolar and coiled-body phosphoprotein 1)(HCV NS5A trans-regulated protein NOLC1 ENSG00000166197 13)(NS5ATP13) [Source:UniProtKB/Swiss-Prot;Acc:Q14978] 5.95 7.57 1.62 3.08 8.87E-06 1.44E-04 1.08E-11 3.63E-10 2.74 1 hsa-miR-155, Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog (Basic FGF-repressed Zic-binding protein)(bFZb) UQCC ENSG00000101019 [Source:UniProtKB/Swiss-Prot;Acc:Q9NVA1] 5.28 6.91 1.63 3.09 4.67E-06 8.55E-05 2.16E-10 5.10E-09 1.91 2 hsa-miR-24,hsa-miR-27a, Dixin (DIX domain-containing protein 1)(Coiled-coil protein DIXDC1 ENSG00000150764 DIX1)(Coiled-coil-DIX1) [Source:UniProtKB/Swiss- 5.37 7.00 1.63 3.10 2.99E-09 2.17E-07 1.39E-10 3.45E-09 1.63 4 hsa-miR-155,hsa-miR-19a,hsa-miR-200b,hsa-miR-206, Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18)(p28b) [Source:UniProtKB/Swiss- MED18 ENSG00000130772 Prot;Acc:Q9BUE0] 5.11 6.74 1.63 3.10 3.51E-08 1.61E-06 1.41E-11 4.58E-10 1.67 1 hsa-miR-19a, Mothers against decapentaplegic homolog 2 (Mothers against DPP homolog 2)(Mad-related protein 2)(hMAD-2)(SMAD SMAD2 ENSG00000175387 2)(hSMAD2)(JV18-1) [Source:UniProtKB/Swiss-Prot;Acc:Q15796] 7.17 8.80 1.63 3.10 2.27E-05 3.08E-04 1.53E-07 1.74E-06 1.63 6 hsa-miR-132,hsa-miR-155,hsa-miR-18a,hsa-miR-200b,hsa-miR-27a,hsa-miR-365, V-type proton ATPase subunit D (V-ATPase subunit D)(Vacuolar proton pump subunit D)(V-ATPase 28 kDa accessory protein) ATP6V1D ENSG00000100554 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5K8] 5.20 6.84 1.64 3.11 6.47E-04 4.79E-03 5.12E-05 3.23E-04 1.81 1 hsa-miR-155, Replication protein A 32 kDa subunit (RP-A p32)(RP-A p34)(Replication factor A protein 2)(RF-A protein 2) RPA2 ENSG00000117748 [Source:UniProtKB/Swiss-Prot;Acc:P15927] 6.29 7.93 1.64 3.11 2.42E-05 3.24E-04 1.17E-07 1.37E-06 1.84 1 hsa-miR-130b, Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT)(EC 2.1.1.77)(Protein-beta-aspartate methyltransferase)(Protein L- isoaspartyl/D-aspartyl methyltransferase)(L-isoaspartyl protein PCMT1 ENSG00000120265 carboxyl methyltransferase) [Source:UniProtKB/Swiss-Prot;Acc:P2 6.74 8.38 1.64 3.12 3.58E-05 4.43E-04 6.15E-08 7.71E-07 1.84 1 hsa-miR-7, Exocyst complex component 2 (Exocyst complex component Sec5) EXOC2 ENSG00000112685 [Source:UniProtKB/Swiss-Prot;Acc:Q96KP1] 5.55 7.19 1.64 3.12 1.32E-06 3.09E-05 9.35E-10 1.83E-08 1.80 1 hsa-miR-424, Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Precursor (EC 1.1.1.41)(Isocitric dehydrogenase)(NAD(+)-specific IDH3A ENSG00000166411 ICDH) [Source:UniProtKB/Swiss-Prot;Acc:P50213] 6.61 8.25 1.64 3.12 1.47E-05 2.17E-04 8.60E-12 2.98E-10 2.76 2 hsa-miR-218,hsa-miR-7, Centromere protein O (CENP-O)(Interphase centromere complex CENPO ENSG00000138092 protein 36) [Source:UniProtKB/Swiss-Prot;Acc:Q9BU64] 5.44 7.08 1.64 3.12 4.68E-11 7.62E-09 4.69E-15 4.35E-13 1.80 1 hsa-miR-132, Sterol regulatory element-binding protein 2 (SREBP-2)(Sterol regulatory element-binding transcription factor 2) [Contains Processed sterol regulatory element-binding protein 2] SREBF2 ENSG00000198911 [Source:UniProtKB/Swiss-Prot;Acc:Q12772] 6.54 8.18 1.65 3.13 4.46E-09 2.98E-07 1.85E-12 7.75E-11 1.65 1 hsa-miR-365, Leucine-rich repeat and coiled-coil domain-containing protein 1 (Centrosomal leucine-rich repeat and coiled-coil domain-containing LRRCC1 ENSG00000133739 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9C099] 4.52 6.17 1.65 3.15 1.62E-05 2.35E-04 1.53E-09 2.85E-08 1.99 1 hsa-miR-222, KIAA1715 ENSG00000144320 Protein lunapark [Source:UniProtKB/Swiss-Prot;Acc:Q9C0E8] 6.12 7.77 1.65 3.15 9.01E-05 9.45E-04 8.54E-07 8.02E-06 1.77 2 hsa-miR-155,hsa-miR-7, Probable UDP-sugar transporter protein SLC35A5 (Solute carrier SLC35A5 ENSG00000138459 family 35 member A5) [Source:UniProtKB/Swiss-Prot;Acc:Q9BS91] 6.25 7.91 1.66 3.16 4.16E-05 4.99E-04 7.82E-06 5.92E-05 1.66 1 hsa-miR-7, Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7)(Kynurenine-- oxoglutarate transaminase III)(Kynurenine aminotransferase III)(KATIII)(Cysteine-S-conjugate beta-lyase 2)(EC 4.4.1.13) CCBL2 ENSG00000137944 [Source:UniProtKB/Swiss-Prot;Acc:Q6YP21] 5.92 7.58 1.66 3.16 3.00E-04 2.54E-03 7.99E-05 4.79E-04 1.66 2 hsa-miR-27a,hsa-miR-7, Nuclear factor of activated T-cells 5 (NF-AT5)(T-cell transcription factor NFAT5)(Tonicity-responsive enhancer-binding protein)(TonE- binding protein)(TonEBP) [Source:UniProtKB/Swiss- hsa-miR-155,hsa-miR-18a,hsa-miR-206,hsa-miR-210,hsa-miR-221,hsa-miR-24,hsa- NFAT5 ENSG00000102908 Prot;Acc:O94916] 6.50 8.16 1.66 3.17 1.83E-06 4.02E-05 9.07E-10 1.78E-08 1.95 8 miR-27a,hsa-miR-7, Adipophilin (Adipose differentiation-related protein)(ADRP) ADFP ENSG00000147872 [Source:UniProtKB/Swiss-Prot;Acc:Q99541] 6.90 8.57 1.67 3.18 3.48E-05 4.34E-04 1.54E-05 1.09E-04 1.67 1 hsa-miR-365, Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines)(PHAPI2)(Silver-stainable protein ANP32B ENSG00000136938 SSP29) [Source:UniProtKB/Swiss-Prot;Acc:Q92688] 6.87 8.55 1.67 3.19 8.14E-06 1.34E-04 2.33E-06 1.99E-05 1.67 1 hsa-miR-206, Protein cornichon homolog (T-cell growth-associated molecule CNIH ENSG00000100528 77)(TGAM77) [Source:UniProtKB/Swiss-Prot;Acc:O95406] 6.54 8.22 1.68 3.19 9.07E-05 9.49E-04 1.80E-05 1.25E-04 1.68 2 hsa-miR-132,hsa-miR-155, Importin subunit alpha-2 (Karyopherin subunit alpha-2)(SRP1- alpha)(RAG cohort protein 1) [Source:UniProtKB/Swiss- KPNA2 ENSG00000182481 Prot;Acc:P52292] 7.51 9.18 1.68 3.20 9.88E-08 3.74E-06 4.42E-11 1.26E-09 1.72 1 hsa-miR-222, Vesicle transport protein GOT1B (Golgi transport 1 homolog B)(hGOT1a)(Putative NF-kappa-B-activating protein 470) GOLT1B ENSG00000111711 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y3E0] 5.96 7.64 1.68 3.20 3.38E-05 4.24E-04 1.28E-07 1.48E-06 1.71 5 hsa-miR-130b,hsa-miR-155,hsa-miR-19b,hsa-miR-218,hsa-miR-27a, RNA polymerase II elongation factor ELL2 [Source:UniProtKB/Swiss- hsa-miR-155,hsa-miR-18a,hsa-miR-19a,hsa-miR-200b,hsa-miR-218,hsa-miR-221,hsa- ELL2 ENSG00000118985 Prot;Acc:O00472] 6.51 8.19 1.68 3.20 8.06E-06 1.33E-04 7.63E-09 1.18E-07 1.68 8 miR-27a,hsa-miR-424, Lys-63-specific deubiquitinase BRCC36 (EC 3.1.2.15)(BRCA1-A complex subunit BRCC36)(BRISC complex subunit BRCC36)(BRCA1/BRCA2-containing complex subunit 3)(BRCA1/BRCA2-containing complex subunit 36) BRCC3 ENSG00000185515 [Source:UniProtKB/Swiss-Prot;Acc:P46736] 5.24 6.92 1.68 3.20 3.80E-07 1.11E-05 1.56E-11 5.01E-10 2.13 2 hsa-miR-21,hsa-miR-218, BYSL ENSG00000112578 Bystin [Source:UniProtKB/Swiss-Prot;Acc:Q13895] 5.68 7.36 1.68 3.20 4.20E-12 1.09E-09 5.10E-19 1.79E-16 2.47 1 hsa-miR-7, Importin subunit beta-1 (Karyopherin subunit beta-1)(Nuclear factor KPNB1 ENSG00000108424 P97)(Importin-90) [Source:UniProtKB/Swiss-Prot;Acc:Q14974] 6.96 8.64 1.68 3.21 4.18E-07 1.19E-05 2.71E-11 8.13E-10 2.01 2 hsa-miR-218,hsa-miR-27a, Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1)(X-linked deafness dystonia protein) TIMM8A ENSG00000126953 [Source:UniProtKB/Swiss-Prot;Acc:O60220] 5.26 6.95 1.68 3.21 1.48E-07 5.22E-06 8.06E-15 6.75E-13 2.51 1 hsa-miR-155, Ubiquitin-conjugating enzyme E2 variant 3 (UEV-3)(EV and lactate/malate dehydrogenase domain-containing protein) UEVLD ENSG00000151116 [Source:UniProtKB/Swiss-Prot;Acc:Q8IX04] 4.99 6.68 1.69 3.22 1.19E-06 2.83E-05 1.43E-10 3.53E-09 2.12 1 hsa-miR-155, E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-)(Signal transduction protein CBL-B)(SH3-binding protein CBL-B)(Casitas B-lineage lymphoma proto-oncogene b)(RING finger protein 56) CBLB ENSG00000114423 [Source:UniProtKB/Swiss-Prot;Acc:Q13191] 7.05 8.74 1.69 3.22 5.92E-06 1.03E-04 1.18E-07 1.38E-06 1.69 1 hsa-miR-27a,

AP-2 complex subunit beta-1 (Adapter-related protein complex 2 beta- 1 subunit)(Beta2-adaptin)(Beta-adaptin)(Plasma membrane adaptor HA2/AP2 adaptin beta subunit)(Clathrin assembly protein complex 2 AP2B1 ENSG00000006125 beta large chain)(AP105B) [Source:UniProtKB/Swiss-Prot;Ac 6.39 8.08 1.69 3.22 4.12E-06 7.73E-05 4.38E-08 5.66E-07 1.69 2 hsa-miR-24,hsa-miR-27a, Chronic lymphocytic leukemia deletion region gene 6 protein (CLL deletion region gene 6 protein) [Source:UniProtKB/Swiss- C13orf1 ENSG00000123178 Prot;Acc:Q5W111] 5.89 7.58 1.69 3.22 5.67E-09 3.68E-07 7.54E-15 6.43E-13 2.13 2 hsa-miR-132,hsa-miR-18a, Cytokine-inducible SH2-containing protein (CIS)(CIS-1)(Suppressor of cytokine signaling)(SOCS)(Protein G18) [Source:UniProtKB/Swiss- CISH ENSG00000114737 Prot;Acc:Q9NSE2] 6.36 8.05 1.69 3.23 5.37E-13 2.02E-10 5.51E-17 8.90E-15 1.94 2 hsa-miR-24,hsa-miR-7, Transcription termination factor 2 (EC 3.6.1.-)(RNA polymerase II termination factor)(Transcription release factor 2)(Factor 2)(F2)(HuF2)(Lodestar homolog) [Source:UniProtKB/Swiss- TTF2 ENSG00000116830 Prot;Acc:Q9UNY4] 5.02 6.71 1.69 3.23 7.04E-08 2.84E-06 3.32E-13 1.73E-11 2.34 1 hsa-miR-221, COP9 signalosome complex subunit 4 (Signalosome subunit 4)(SGN4)(JAB1-containing signalosome subunit 4) COPS4 ENSG00000138663 [Source:UniProtKB/Swiss-Prot;Acc:Q9BT78] 5.90 7.59 1.69 3.23 2.97E-04 2.52E-03 1.36E-06 1.22E-05 2.11 1 hsa-miR-21, Carbonyl reductase 4 (EC 1.1.1.-) [Source:UniProtKB/Swiss- CBR4 ENSG00000145439 Prot;Acc:Q8N4T8] 5.34 7.03 1.70 3.24 9.44E-07 2.33E-05 1.14E-10 2.89E-09 2.00 5 hsa-miR-155,hsa-miR-18a,hsa-miR-21,hsa-miR-221,hsa-miR-365, Nuclear transcription factor Y subunit beta (Nuclear transcription factor Y subunit B)(NF-YB)(CAAT-box DNA-binding protein subunit NFYB ENSG00000120837 B) [Source:UniProtKB/Swiss-Prot;Acc:P25208] 5.13 6.83 1.70 3.25 3.68E-05 4.52E-04 2.61E-07 2.79E-06 2.14 3 hsa-miR-132,hsa-miR-222,hsa-miR-7, Transcription elongation factor B polypeptide 1 (RNA polymerase II transcription factor SIII subunit C)(SIII p15)(Elongin 15 kDa subunit)(Elongin-C)(EloC) [Source:UniProtKB/Swiss- TCEB1 ENSG00000154582 Prot;Acc:Q15369] 7.92 9.62 1.70 3.25 1.37E-07 4.89E-06 3.66E-12 1.41E-10 2.07 2 hsa-miR-132,hsa-miR-200b, Ras-related protein Rap-1A Precursor (GTP-binding protein smg- p21A)(Ras-related protein Krev-1)(C21KG)(G-22K) RAP1A ENSG00000116473 [Source:UniProtKB/Swiss-Prot;Acc:P62834] 7.74 9.44 1.70 3.26 3.21E-05 4.07E-04 1.89E-07 2.09E-06 1.70 3 hsa-miR-19a,hsa-miR-24,hsa-miR-7, Signal peptidase complex subunit 2 (EC 3.4.-.-)(Microsomal signal peptidase 25 kDa subunit)(SPase 25 kDa subunit) SPCS2 ENSG00000118363 [Source:UniProtKB/Swiss-Prot;Acc:Q15005] 6.97 8.67 1.70 3.26 3.50E-06 6.84E-05 3.23E-10 7.24E-09 1.70 3 hsa-miR-132,hsa-miR-200b,hsa-miR-24, Mid1-interacting protein 1 (Gastrulation-specific G12-like protein)(Mid1-interacting G12-like protein)(Protein STRAIT11499) MID1IP1 ENSG00000165175 [Source:UniProtKB/Swiss-Prot;Acc:Q9NPA3] 5.89 7.60 1.71 3.27 6.27E-08 2.59E-06 6.85E-13 3.21E-11 1.83 1 hsa-miR-19a, SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating SAE1 ENSG00000142230 enzyme E1A) [Source:UniProtKB/Swiss-Prot;Acc:Q9UBE0] 7.81 9.52 1.71 3.27 4.54E-07 1.28E-05 1.17E-11 3.89E-10 1.71 1 hsa-miR-7, Glycerol-3-phosphate dehydrogenase, mitochondrial Precursor (GPDH-M)(GPD-M)(EC 1.1.5.3)(mtGPD) [Source:UniProtKB/Swiss- GPD2 ENSG00000115159 Prot;Acc:P43304] 5.52 7.23 1.71 3.27 1.60E-07 5.55E-06 5.98E-10 1.24E-08 1.77 2 hsa-miR-206,hsa-miR-27a, MCOLN2 ENSG00000153898 Mucolipin-2 [Source:UniProtKB/Swiss-Prot;Acc:Q8IZK6] 5.72 7.44 1.71 3.27 8.39E-09 5.04E-07 6.70E-14 4.38E-12 1.77 2 hsa-miR-221,hsa-miR-365, CLDN12 ENSG00000157224 Claudin-12 [Source:UniProtKB/Swiss-Prot;Acc:P56749] 5.38 7.09 1.71 3.28 5.33E-09 3.50E-07 8.20E-10 1.64E-08 1.71 3 hsa-miR-221,hsa-miR-424,hsa-miR-7, Coiled-coil domain-containing protein 41 (Renal carcinoma antigen CCDC41 ENSG00000173588 NY-REN-58) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y592] 5.04 6.75 1.71 3.28 3.60E-06 6.99E-05 4.78E-10 1.02E-08 2.02 1 hsa-miR-155, UPF0554 protein C2orf43 [Source:UniProtKB/Swiss- C2orf43 ENSG00000118961 Prot;Acc:Q9H6V9] 5.04 6.76 1.71 3.28 1.35E-05 2.02E-04 2.59E-08 3.54E-07 2.01 3 hsa-miR-155,hsa-miR-206,hsa-miR-24, ATP-dependent RNA helicase DDX1 (EC 3.6.1.-)(DEAD box protein 1)(DEAD box protein retinoblastoma)(DBP-RB) DDX1 ENSG00000079785 [Source:UniProtKB/Swiss-Prot;Acc:Q92499] 6.25 7.96 1.71 3.28 1.10E-04 1.11E-03 2.13E-09 3.80E-08 2.67 1 hsa-miR-200b, GDP-fucose protein O-fucosyltransferase 1 Precursor (EC 2.4.1.221)(Peptide-O-fucosyltransferase 1)(O-FucT-1) POFUT1 ENSG00000101346 [Source:UniProtKB/Swiss-Prot;Acc:Q9H488] 5.86 7.57 1.72 3.28 7.95E-10 7.41E-08 7.83E-14 5.03E-12 1.84 1 hsa-miR-18a, Basic immunoglobulin-like variable motif-containing protein BIVM ENSG00000134897 [Source:UniProtKB/Swiss-Prot;Acc:Q86UB2] 4.78 6.50 1.72 3.29 1.63E-06 3.67E-05 1.72E-09 3.13E-08 2.14 1 hsa-miR-218, Sugar phosphate exchanger 3 (Solute carrier family 37 member 3) SLC37A3 ENSG00000157800 [Source:UniProtKB/Swiss-Prot;Acc:Q8NCC5] 6.79 8.51 1.72 3.29 1.36E-07 4.87E-06 3.86E-10 8.50E-09 1.81 1 hsa-miR-7, Interleukin-2 receptor subunit beta Precursor (High affinity IL-2 receptor subunit beta)(IL-2 receptor)(P70-75)(p75)(CD122 antigen) IL2RB ENSG00000100385 [Source:UniProtKB/Swiss-Prot;Acc:P14784] 7.70 9.42 1.72 3.30 2.38E-07 7.65E-06 6.49E-10 1.34E-08 1.72 1 hsa-miR-24, Macrophage colony-stimulating factor 1 Precursor (CSF- 1)(MCSF)(M-CSF)(Lanimostim) [Contains Processed macrophage CSF1 ENSG00000184371 colony-stimulating factor 1] [Source:UniProtKB/Swiss- 5.73 7.45 1.72 3.30 1.86E-12 5.83E-10 1.26E-14 1.01E-12 1.89 2 hsa-miR-210,hsa-miR-27a, Semaphorin-7A Precursor (Semaphorin-L)(Sema L)(Semaphorin- K1)(Sema K1)(John-Milton-Hargen human blood group Ag)(JMH blood group antigen)(CDw108)(CD108 antigen) SEMA7A ENSG00000138623 [Source:UniProtKB/Swiss-Prot;Acc:O75326] 5.83 7.56 1.73 3.32 2.09E-10 2.43E-08 2.15E-11 6.65E-10 1.84 1 hsa-miR-7, Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1)(p120 CAND1)(TBP-interacting protein TIP120A)(TBP-interacting protein of 120 kDa A) CAND1 ENSG00000111530 [Source:UniProtKB/Swiss-Prot;Acc:Q86VP6] 6.72 8.45 1.73 3.32 1.02E-05 1.60E-04 2.68E-08 3.64E-07 1.96 3 hsa-miR-19a,hsa-miR-221,hsa-miR-7, G-protein-signaling modulator 2 (Mosaic protein LGN) GPSM2 ENSG00000121957 [Source:UniProtKB/Swiss-Prot;Acc:P81274] 4.84 6.57 1.73 3.32 1.75E-10 2.09E-08 7.69E-14 4.94E-12 1.73 1 hsa-miR-155, FLOT1 ENSG00000137312 Flotillin-1 [Source:UniProtKB/Swiss-Prot;Acc:O75955] 6.87 8.61 1.73 3.33 4.12E-09 2.80E-07 2.15E-16 2.91E-14 2.07 1 hsa-miR-132, Leucine-rich repeat-containing protein 42 [Source:UniProtKB/Swiss- LRRC42 ENSG00000116212 Prot;Acc:Q9Y546] 5.57 7.31 1.73 3.33 1.09E-08 6.27E-07 5.24E-11 1.47E-09 1.73 1 hsa-miR-365, CTP synthase 1 (EC 6.3.4.2)(UTP--ammonia ligase 1)(CTP CTPS ENSG00000171793 synthetase 1) [Source:UniProtKB/Swiss-Prot;Acc:P17812] 6.16 7.90 1.74 3.33 6.05E-07 1.62E-05 1.58E-14 1.22E-12 2.89 1 hsa-miR-7, Protein mago nashi homolog 2 [Source:UniProtKB/Swiss- MAGOHB ENSG00000111196 Prot;Acc:Q96A72] 5.41 7.14 1.74 3.34 2.57E-07 8.14E-06 4.68E-14 3.15E-12 2.68 1 hsa-miR-7, Proteasome-associated protein ECM29 homolog (Ecm29) KIAA0368 ENSG00000136813 [Source:UniProtKB/Swiss-Prot;Acc:Q5VYK3] 6.48 8.21 1.74 3.34 3.01E-06 6.05E-05 5.19E-09 8.29E-08 1.77 2 hsa-miR-222,hsa-miR-7, Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-)(DEAD box protein 41)(DEAD box protein abstrakt homolog) DDX41 ENSG00000183258 [Source:UniProtKB/Swiss-Prot;Acc:Q9UJV9] 6.89 8.63 1.74 3.35 2.03E-07 6.77E-06 3.76E-11 1.10E-09 1.90 1 hsa-miR-7,

Putative deoxyribonuclease TATDN1 (EC 3.1.21.-)(Hepatocarcinoma TATDN1 ENSG00000147687 high expression protein) [Source:UniProtKB/Swiss-Prot;Acc:Q6P1N9] 6.69 8.44 1.74 3.35 3.16E-04 2.66E-03 5.16E-06 4.08E-05 1.80 1 hsa-miR-7, Thiamine transporter 1 (ThTr-1)(ThTr1)(Thiamine carrier 1)(TC1)(Solute carrier family 19 member 2) [Source:UniProtKB/Swiss- SLC19A2 ENSG00000117479 Prot;Acc:O60779] 5.32 7.07 1.75 3.37 1.00E-07 3.79E-06 2.06E-13 1.17E-11 2.53 1 hsa-miR-24, ADP-ribosylation factor-like protein 3 [Source:UniProtKB/Swiss- ARL3 ENSG00000138175 Prot;Acc:P36405] 6.15 7.91 1.76 3.38 2.27E-08 1.15E-06 4.88E-12 1.80E-10 1.89 3 hsa-miR-200b,hsa-miR-218,hsa-miR-424, Zinc finger CCCH domain-containing protein 8 ZC3H8 ENSG00000144161 [Source:UniProtKB/Swiss-Prot;Acc:Q8N5P1] 5.48 7.23 1.76 3.38 2.22E-05 3.02E-04 1.75E-08 2.48E-07 2.04 1 hsa-miR-7, Wiskott-Aldrich syndrome protein family member 1 (WASP family protein member 1)(Protein WAVE-1)(Verprolin homology domain- WASF1 ENSG00000112290 containing protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q92558] 4.29 6.05 1.76 3.38 3.67E-07 1.08E-05 6.71E-07 6.46E-06 1.90 1 hsa-miR-200b,

Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1)(Serine/arginine- rich protein-specific kinase 1)(SR-protein-specific kinase 1)(SFRS SRPK1 ENSG00000096063 protein kinase 1) [Source:UniProtKB/Swiss-Prot;Acc:Q96SB4] 6.11 7.87 1.76 3.38 6.24E-07 1.66E-05 8.80E-12 3.04E-10 2.28 2 hsa-miR-21,hsa-miR-7, Tumor necrosis factor receptor superfamily member 6 Precursor (FASLG receptor)(Apoptosis-mediating surface antigen FAS)(Apo-1 FAS ENSG00000026103 antigen)(CD95 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25445] 6.21 7.97 1.76 3.38 1.34E-05 2.00E-04 4.76E-07 4.77E-06 1.76 1 hsa-miR-98, SH2 domain-containing protein 2A (T cell-specific adapter protein)(TSAd)(VEGF receptor-associated protein)(SH2 domain- containing adapter protein) [Source:UniProtKB/Swiss- SH2D2A ENSG00000027869 Prot;Acc:Q9NP31] 6.10 7.86 1.76 3.40 7.00E-08 2.83E-06 2.18E-11 6.73E-10 1.92 1 hsa-miR-24, Inositol monophosphatase 3 (EC 3.1.3.25)(Inositol-1(or 4)- monophosphatase 3)(IMPase 3)(IMP 3)(Myo-inositol monophosphatase A3)(Inositol monophosphatase domain-containing IMPAD1 ENSG00000104331 protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q9NX62] 6.48 8.25 1.76 3.40 1.31E-05 1.96E-04 3.31E-07 3.43E-06 1.76 3 hsa-miR-155,hsa-miR-218,hsa-miR-365, Ras-related protein Rab-10 [Source:UniProtKB/Swiss- RAB10 ENSG00000084733 Prot;Acc:P61026] 6.52 8.29 1.76 3.40 3.51E-05 4.36E-04 2.92E-08 3.93E-07 2.23 1 hsa-miR-7, Citron Rho-interacting kinase (CRIK)(EC 2.7.11.1)(Rho-interacting, serine/threonine-protein kinase 21) [Source:UniProtKB/Swiss- CIT ENSG00000122966 Prot;Acc:O14578] 4.97 6.73 1.77 3.40 5.44E-11 8.50E-09 5.45E-15 4.99E-13 1.77 4 hsa-miR-130b,hsa-miR-19a,hsa-miR-221,hsa-miR-7, DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit)(DNA-PKcs)(EC 2.7.11.1)(DNPK1)(p460) PRKDC ENSG00000121031 [Source:UniProtKB/Swiss-Prot;Acc:P78527] 6.04 7.81 1.77 3.40 1.86E-06 4.08E-05 2.22E-10 5.22E-09 2.37 1 hsa-miR-155, Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6)(Ubiquitin-activating enzyme E1-like protein 2)(Monocyte UBA6 ENSG00000033178 protein 4)(MOP-4) [Source:UniProtKB/Swiss-Prot;Acc:A0AVT1] 5.94 7.70 1.77 3.40 9.19E-06 1.47E-04 1.83E-07 2.04E-06 1.77 1 hsa-miR-200b, N-acetyltransferase 5 (EC 2.3.1.-) [Source:UniProtKB/Swiss- NAT5 ENSG00000173418 Prot;Acc:P61599] 5.46 7.23 1.77 3.41 5.54E-05 6.37E-04 7.75E-08 9.47E-07 2.40 1 hsa-miR-132, E3 ubiquitin-protein ligase SIAH2 (EC 6.3.2.-)(Seven in absentia homolog 2)(Siah-2)(hSiah2) [Source:UniProtKB/Swiss- SIAH2 ENSG00000181788 Prot;Acc:O43255] 7.22 8.99 1.77 3.41 9.52E-07 2.34E-05 2.43E-08 3.34E-07 1.77 1 hsa-miR-218, Golgi phosphoprotein 3-like (GPP34-related protein) GOLPH3L ENSG00000143457 [Source:UniProtKB/Swiss-Prot;Acc:Q9H4A5] 5.63 7.40 1.77 3.41 7.69E-07 1.98E-05 9.59E-09 1.45E-07 1.77 3 hsa-miR-155,hsa-miR-221,hsa-miR-7,

26S proteasome non-ATPase regulatory subunit 12 (26S proteasome PSMD12 ENSG00000197170 regulatory subunit p55) [Source:UniProtKB/Swiss-Prot;Acc:O00232] 5.93 7.71 1.78 3.42 3.92E-06 7.44E-05 1.83E-11 5.78E-10 2.71 1 hsa-miR-132, DEK ENSG00000124795 Protein DEK [Source:UniProtKB/Swiss-Prot;Acc:P35659] 7.07 8.85 1.78 3.43 7.69E-05 8.33E-04 1.05E-06 9.69E-06 1.80 2 hsa-miR-155,hsa-miR-218, Intermediate conductance calcium-activated potassium channel protein 4 (SK4)(KCa4)(IKCa1)(IK1)(Putative Gardos channel) KCNN4 ENSG00000104783 [Source:UniProtKB/Swiss-Prot;Acc:O15554] 6.24 8.02 1.78 3.43 5.00E-10 5.02E-08 1.14E-14 9.21E-13 1.78 1 hsa-miR-424, Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4)(Phosphoglucosamine transacetylase)(Phosphoglucosamine GNPNAT1 ENSG00000100522 acetylase) [Source:UniProtKB/Swiss-Prot;Acc:Q96EK6] 5.54 7.32 1.78 3.43 8.21E-07 2.09E-05 1.15E-13 7.00E-12 2.58 1 hsa-miR-155, Proteasome subunit alpha type-1 (EC 3.4.25.1)(Proteasome component C2)(Macropain subunit C2)(Multicatalytic endopeptidase complex subunit C2)(Proteasome nu chain)(30 kDa prosomal PSMA1 ENSG00000129084 protein)(PROS-30) [Source:UniProtKB/Swiss-Prot;Acc:P25786] 7.76 9.54 1.78 3.43 2.21E-06 4.68E-05 1.11E-10 2.84E-09 2.05 1 hsa-miR-27a, Polyribonucleotide nucleotidyltransferase 1, mitochondrial Precursor (EC 2.7.7.8)(PNPase 1)(Polynucleotide phosphorylase-like protein)(PNPase old-35)(3'-5' RNA exonuclease OLD35) PNPT1 ENSG00000138035 [Source:UniProtKB/Swiss-Prot;Acc:Q8TCS8] 5.25 7.03 1.78 3.44 8.96E-06 1.44E-04 2.15E-12 8.81E-11 2.94 1 hsa-miR-7, Interleukin-9 Precursor (IL-9)(T-cell growth factor P40)(P40 cytokine) IL9 ENSG00000145839 [Source:UniProtKB/Swiss-Prot;Acc:P15248] 5.05 6.83 1.78 3.44 8.52E-07 2.15E-05 8.54E-12 2.97E-10 3.25 1 hsa-miR-21, Uncharacterized protein C14orf119 [Source:UniProtKB/Swiss- C14orf119 ENSG00000179933 Prot;Acc:Q9NWQ9] 5.87 7.66 1.78 3.44 1.65E-05 2.38E-04 3.55E-08 4.67E-07 2.07 2 hsa-miR-155,hsa-miR-21, Putative adenosylhomocysteinase 2 (AdoHcyase 2)(EC 3.3.1.1)(S- adenosyl-L-homocysteine hydrolase 2)(S-adenosylhomocysteine hydrolase-like protein 1)(DC-expressed AHCY-like molecule) AHCYL1 ENSG00000168710 [Source:UniProtKB/Swiss-Prot;Acc:O43865] 6.81 8.60 1.79 3.46 1.07E-06 2.58E-05 3.93E-10 8.64E-09 1.98 1 hsa-miR-135b, MICAL2 ENSG00000133816 Protein MICAL-2 [Source:UniProtKB/Swiss-Prot;Acc:O94851] 5.90 7.70 1.80 3.48 7.64E-16 1.37E-12 9.55E-18 2.03E-15 1.80 1 hsa-miR-19a, PDZ domain-containing protein 11 [Source:UniProtKB/Swiss- PDZD11 ENSG00000120509 Prot;Acc:Q5EBL8] 5.42 7.22 1.80 3.48 3.77E-05 4.61E-04 2.90E-07 3.05E-06 1.94 1 hsa-miR-7, Protein YIPF6 (YIP1 family member 6) [Source:UniProtKB/Swiss- YIPF6 ENSG00000181704 Prot;Acc:Q96EC8] 5.94 7.74 1.80 3.48 2.86E-07 8.83E-06 6.07E-11 1.67E-09 1.80 1 hsa-miR-218, SURF4 ENSG00000148248 Surfeit locus protein 4 [Source:UniProtKB/Swiss-Prot;Acc:O15260] 7.79 9.59 1.80 3.48 2.53E-08 1.25E-06 1.58E-14 1.22E-12 1.80 1 hsa-miR-27a, Proteasome maturation protein (Proteassemblin)(Protein UMP1 homolog)(hUMP1)(Voltage-gated K channel beta subunit 4.1) POMP ENSG00000132963 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y244] 7.83 9.63 1.80 3.49 1.50E-07 5.27E-06 1.75E-12 7.34E-11 2.31 2 hsa-miR-132,hsa-miR-155, La-related protein 4 (La ribonucleoprotein domain family member 4) LARP4 ENSG00000161813 [Source:UniProtKB/Swiss-Prot;Acc:Q71RC2] 5.12 6.93 1.81 3.50 2.02E-06 4.36E-05 3.72E-11 1.09E-09 2.51 2 hsa-miR-27a,hsa-miR-7, Transmembrane protein 69 [Source:UniProtKB/Swiss- TMEM69 ENSG00000159596 Prot;Acc:Q5SWH9] 6.67 8.48 1.81 3.51 4.36E-06 8.11E-05 1.48E-09 2.76E-08 2.16 1 hsa-miR-7, Echinoderm microtubule-associated protein-like 5 (EMAP-5) EML5 ENSG00000165521 [Source:UniProtKB/Swiss-Prot;Acc:Q05BV3] 4.85 6.66 1.81 3.51 8.87E-07 2.21E-05 9.93E-09 1.49E-07 1.81 2 hsa-miR-155,hsa-miR-29b, 28S ribosomal protein S27, mitochondrial (S27mt)(MRP-S27) MRPS27 ENSG00000113048 [Source:UniProtKB/Swiss-Prot;Acc:Q92552] 6.04 7.85 1.81 3.51 1.63E-05 2.35E-04 5.73E-09 9.08E-08 2.09 1 hsa-miR-27a, Centromere/kinetochore protein zw10 homolog ZW10 ENSG00000086827 [Source:UniProtKB/Swiss-Prot;Acc:O43264] 4.93 6.75 1.82 3.52 2.61E-06 5.38E-05 4.81E-10 1.03E-08 2.33 1 hsa-miR-155, Monocarboxylate transporter 1 (MCT 1)(Solute carrier family 16 SLC16A1 ENSG00000155380 member 1) [Source:UniProtKB/Swiss-Prot;Acc:P53985] 6.12 7.94 1.82 3.53 4.14E-08 1.83E-06 1.22E-13 7.34E-12 2.15 2 hsa-miR-200b,hsa-miR-424, V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2)(Vacuolar proton pump subunit B 2)(Endomembrane proton pump 58 ATP6V1B2 ENSG00000147416 kDa subunit)(HO57) [Source:UniProtKB/Swiss-Prot;Acc:P21281] 7.12 8.94 1.82 3.53 7.00E-06 1.18E-04 2.90E-09 4.99E-08 1.99 1 hsa-miR-19a, Coiled-coil domain-containing protein 127 [Source:UniProtKB/Swiss- CCDC127 ENSG00000164366 Prot;Acc:Q96BQ5] 4.96 6.79 1.82 3.54 2.52E-06 5.22E-05 3.08E-08 4.12E-07 1.82 1 hsa-miR-7, DNA repair protein XRCC2 (X-ray repair cross-complementing XRCC2 ENSG00000196584 protein 2) [Source:UniProtKB/Swiss-Prot;Acc:O43543] 4.97 6.80 1.83 3.54 2.91E-11 5.20E-09 3.34E-19 1.24E-16 2.57 1 hsa-miR-7, 5'-nucleotidase Precursor (EC 3.1.3.5)(Ecto-5'-nucleotidase)(5'- NT5E ENSG00000135318 NT)(CD73 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P21589] 5.36 7.18 1.83 3.54 1.09E-05 1.69E-04 3.92E-08 5.11E-07 1.95 2 hsa-miR-155,hsa-miR-218, CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.99.-)(Alpha-2,8-sialyltransferase 8D)(ST8Sia IV)(Polysialyltransferase-1) [Source:UniProtKB/Swiss- ST8SIA4 ENSG00000113532 Prot;Acc:Q92187] 6.94 8.77 1.83 3.55 5.68E-06 9.99E-05 2.32E-07 2.51E-06 1.83 3 hsa-miR-19a,hsa-miR-218,hsa-miR-365, T-complex protein 1 subunit beta (TCP-1-beta)(CCT-beta) CCT2 ENSG00000166226 [Source:UniProtKB/Swiss-Prot;Acc:P78371] 7.39 9.22 1.83 3.56 1.72E-06 3.83E-05 2.29E-11 7.04E-10 2.52 1 hsa-miR-155, Actin-like protein 6A (53 kDa BRG1-associated factor A)(Actin-related protein Baf53a)(ArpNbeta)(INO80 complex subunit K) ACTL6A ENSG00000136518 [Source:UniProtKB/Swiss-Prot;Acc:O96019] 5.91 7.75 1.84 3.57 1.81E-06 4.00E-05 3.01E-11 8.94E-10 2.35 1 hsa-miR-18a, Nucleolar RNA helicase 2 (EC 3.6.1.-)(Nucleolar RNA helicase II)(Nucleolar RNA helicase Gu)(RH II/Gu)(Gu-alpha)(DEAD box DDX21 ENSG00000165732 protein 21) [Source:UniProtKB/Swiss-Prot;Acc:Q9NR30] 6.61 8.45 1.84 3.59 7.44E-07 1.93E-05 3.52E-12 1.35E-10 2.39 1 hsa-miR-218,

CCNE2 ENSG00000175305 G1/S-specific cyclin-E2 [Source:UniProtKB/Swiss-Prot;Acc:O96020] 3.28 5.13 1.85 3.60 5.39E-06 9.58E-05 5.73E-14 3.78E-12 3.41 1 hsa-miR-200b, Transcription factor Maf (Proto-oncogene c-maf)(C-Maf)(V-maf musculoaponeurotic fibrosarcoma oncogene homolog) MAF ENSG00000178573 [Source:UniProtKB/Swiss-Prot;Acc:O75444] 5.99 7.84 1.85 3.60 8.23E-10 7.61E-08 1.39E-14 1.09E-12 1.85 6 hsa-miR-130b,hsa-miR-132,hsa-miR-200b,hsa-miR-206,hsa-miR-210,hsa-miR-365, Exocyst complex component 5 (Exocyst complex component EXOC5 ENSG00000070367 Sec10)(hSec10) [Source:UniProtKB/Swiss-Prot;Acc:O00471] 5.80 7.65 1.85 3.60 1.92E-05 2.69E-04 2.60E-08 3.54E-07 2.09 5 hsa-miR-19a,hsa-miR-218,hsa-miR-221,hsa-miR-24,hsa-miR-424, Hematological and neurological expressed 1 protein (Androgen- HN1 ENSG00000189159 regulated protein 2) [Source:UniProtKB/Swiss-Prot;Acc:Q9UK76] 6.22 8.07 1.85 3.60 1.20E-07 4.38E-06 4.49E-11 1.28E-09 2.10 2 hsa-miR-132,hsa-miR-7, ER lumen protein retaining receptor 2 (KDEL endoplasmic reticulum protein retention receptor 2)(KDEL receptor 2)(ERD2-like protein KDELR2 ENSG00000136240 1)(ELP-1) [Source:UniProtKB/Swiss-Prot;Acc:P33947] 7.51 9.37 1.85 3.61 6.99E-06 1.18E-04 1.43E-09 2.68E-08 2.31 1 hsa-miR-7, Membrane-associated progesterone receptor component 1 (mPR) PGRMC1 ENSG00000101856 [Source:UniProtKB/Swiss-Prot;Acc:O00264] 6.24 8.10 1.85 3.61 1.07E-05 1.67E-04 5.59E-11 1.55E-09 2.62 1 hsa-miR-7, Methylglutaconyl-CoA hydratase, mitochondrial Precursor (EC 4.2.1.18)(AU-specific RNA-binding enoyl-CoA hydratase)(AU- binding protein/enoyl-CoA hydratase) [Source:UniProtKB/Swiss- AUH ENSG00000148090 Prot;Acc:Q13825] 6.12 7.97 1.85 3.62 4.82E-08 2.08E-06 9.06E-13 4.11E-11 1.85 1 hsa-miR-155, YEATS domain-containing protein 2 [Source:UniProtKB/Swiss- YEATS2 ENSG00000163872 Prot;Acc:Q9ULM3] 5.78 7.63 1.86 3.62 2.82E-07 8.73E-06 5.10E-09 8.17E-08 1.86 1 hsa-miR-155, THUMP domain-containing protein 3 [Source:UniProtKB/Swiss- THUMPD3 ENSG00000134077 Prot;Acc:Q9BV44] 5.78 7.64 1.86 3.62 5.75E-06 1.01E-04 1.09E-08 1.63E-07 1.91 1 hsa-miR-155, Nucleoside diphosphate kinase 7 (NDP kinase 7)(NDK 7)(EC NME7 ENSG00000143156 2.7.4.6)(nm23-H7) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5B8] 5.35 7.21 1.86 3.62 1.61E-05 2.34E-04 7.36E-07 7.02E-06 1.87 1 hsa-miR-19b, Ras-related protein Rab-13 (Cell growth-inhibiting gene 4 protein) RAB13 ENSG00000143545 [Source:UniProtKB/Swiss-Prot;Acc:P51153] 4.82 6.68 1.86 3.63 2.29E-10 2.61E-08 3.59E-12 1.38E-10 1.86 1 hsa-miR-19a, Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase)(EC 2.3.3.10)(3-hydroxy-3-methylglutaryl coenzyme A HMGCS1 ENSG00000112972 synthase) [Source:UniProtKB/Swiss-Prot;Acc:Q01581] 5.72 7.58 1.86 3.63 4.36E-07 1.24E-05 1.39E-13 8.26E-12 2.86 5 hsa-miR-155,hsa-miR-18a,hsa-miR-19a,hsa-miR-27a,hsa-miR-365, WD repeat-containing protein 36 (T-cell activation WD repeat- containing protein)(TA-WDRP) [Source:UniProtKB/Swiss- WDR36 ENSG00000134987 Prot;Acc:Q8NI36] 6.14 8.01 1.86 3.64 9.13E-07 2.26E-05 6.08E-11 1.67E-09 2.46 1 hsa-miR-7, Motile sperm domain-containing protein 2 [Source:UniProtKB/Swiss- MOSPD2 ENSG00000130150 Prot;Acc:Q8NHP6] 4.74 6.60 1.87 3.64 2.93E-05 3.78E-04 2.47E-07 2.65E-06 1.87 1 hsa-miR-18a, CD166 antigen Precursor (Activated leukocyte cell adhesion molecule)(CD166 antigen) [Source:UniProtKB/Swiss- ALCAM ENSG00000170017 Prot;Acc:Q13740] 5.11 6.97 1.87 3.65 7.81E-08 3.08E-06 1.24E-11 4.13E-10 2.35 3 hsa-miR-135b,hsa-miR-18a,hsa-miR-200b, TPR repeat-containing protein C12orf30 (p120) C12orf30 ENSG00000111300 [Source:UniProtKB/Swiss-Prot;Acc:Q14CX7] 4.92 6.79 1.87 3.65 3.20E-06 6.36E-05 7.86E-09 1.21E-07 2.00 2 hsa-miR-222,hsa-miR-7, Tetraspanin-5 (Tspan-5)(Transmembrane 4 superfamily member TSPAN5 ENSG00000168785 9)(Tetraspan NET-4) [Source:UniProtKB/Swiss-Prot;Acc:P62079] 6.38 8.25 1.87 3.65 1.16E-07 4.24E-06 2.23E-09 3.94E-08 1.87 1 hsa-miR-424, Puromycin-sensitive aminopeptidase (PSA)(EC 3.4.11.-) NPEPPS ENSG00000141279 [Source:UniProtKB/Swiss-Prot;Acc:P55786] 7.19 9.06 1.87 3.65 1.09E-06 2.61E-05 3.43E-09 5.78E-08 1.87 1 hsa-miR-27a, UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase)(UDP- GlcDH)(UDPGDH)(EC 1.1.1.22) [Source:UniProtKB/Swiss- UGDH ENSG00000109814 Prot;Acc:O60701] 4.75 6.62 1.87 3.65 2.23E-07 7.26E-06 8.73E-12 3.02E-10 2.13 1 hsa-miR-155, ADP-ribosylation factor-like protein 1 [Source:UniProtKB/Swiss- ARL1 ENSG00000120805 Prot;Acc:P40616] 5.78 7.65 1.87 3.66 7.66E-06 1.28E-04 8.56E-10 1.70E-08 2.28 1 hsa-miR-155, Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial Precursor (dUTPase)(EC 3.6.1.23)(dUTP pyrophosphatase) DUT ENSG00000128951 [Source:UniProtKB/Swiss-Prot;Acc:P33316] 6.81 8.69 1.87 3.66 2.37E-06 4.96E-05 4.36E-10 9.45E-09 2.20 1 hsa-miR-218, Fanconi anemia group D2 protein (Protein FACD2) FANCD2 ENSG00000144554 [Source:UniProtKB/Swiss-Prot;Acc:Q9BXW9] 5.44 7.32 1.88 3.67 4.27E-09 2.87E-07 2.74E-13 1.48E-11 2.03 2 hsa-miR-18a,hsa-miR-218, GTP-binding protein SAR1b (GTBPB) [Source:UniProtKB/Swiss- SAR1B ENSG00000152700 Prot;Acc:Q9Y6B6] 5.72 7.60 1.88 3.69 7.42E-05 8.09E-04 5.57E-07 5.48E-06 2.19 1 hsa-miR-363,

Asparaginyl-tRNA synthetase, cytoplasmic (EC 6.1.1.22)(Asparagine-- NARS ENSG00000134440 tRNA ligase)(AsnRS) [Source:UniProtKB/Swiss-Prot;Acc:O43776] 7.26 9.14 1.88 3.69 6.75E-06 1.15E-04 2.30E-10 5.37E-09 2.22 1 hsa-miR-155, SNX10 ENSG00000086300 Sorting nexin-10 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5X0] 5.77 7.65 1.88 3.69 3.73E-08 1.68E-06 6.36E-12 2.27E-10 2.27 1 hsa-miR-27a,

Calcium/calmodulin-dependent protein kinase type II delta chain (CaM- kinase II delta chain)(CaM kinase II subunit delta)(CaMK-II subunit CAMK2D ENSG00000145349 delta)(EC 2.7.11.17) [Source:UniProtKB/Swiss-Prot;Acc:Q13557] 6.03 7.92 1.88 3.69 6.17E-06 1.07E-04 1.14E-07 1.34E-06 1.88 3 hsa-miR-24,hsa-miR-27a,hsa-miR-7, Serologically defined breast cancer antigen NY-BR-73 Fragment COPG2 ENSG00000158623 [Source:UniProtKB/TrEMBL;Acc:Q9H279] 5.33 7.22 1.89 3.70 2.77E-05 3.60E-04 1.99E-06 1.73E-05 1.89 1 hsa-miR-24, Condensin-2 complex subunit D3 (Non-SMC condensin II complex NCAPD3 ENSG00000151503 subunit D3)(hCAP-D3) [Source:UniProtKB/Swiss-Prot;Acc:P42695] 5.71 7.60 1.89 3.72 1.42E-07 5.03E-06 9.48E-13 4.27E-11 2.47 1 hsa-miR-21, Vacuolar protein sorting-associated protein 35 (Vesicle protein sorting 35)(hVPS35)(Maternal-embryonic 3) VPS35 ENSG00000069329 [Source:UniProtKB/Swiss-Prot;Acc:Q96QK1] 6.63 8.53 1.89 3.72 2.23E-05 3.03E-04 1.33E-08 1.93E-07 2.10 1 hsa-miR-19a, Alkylated DNA repair protein alkB homolog 1 ALKBH1 ENSG00000100601 [Source:UniProtKB/Swiss-Prot;Acc:Q13686] 5.08 6.97 1.89 3.72 2.67E-07 8.42E-06 3.42E-09 5.77E-08 1.89 1 hsa-miR-7, Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62)(17-beta- hydroxysteroid dehydrogenase 12)(17-beta-HSD 12)(3-ketoacyl-CoA reductase)(KAR)(EC 1.3.1.-) [Source:UniProtKB/Swiss- HSD17B12 ENSG00000149084 Prot;Acc:Q53GQ0] 5.85 7.75 1.90 3.72 5.55E-06 9.83E-05 1.54E-10 3.75E-09 2.51 2 hsa-miR-155,hsa-miR-7, DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog)(Heat shock protein 40 homolog)(HSP40 homolog)(Human DNAJB4 ENSG00000162616 liver DnaJ-like protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9UDY4] 5.29 7.19 1.90 3.72 9.67E-07 2.37E-05 2.35E-08 3.24E-07 1.90 2 hsa-miR-222,hsa-miR-424, F-box only protein 22 (F-box protein FBX22p44) FBXO22 ENSG00000167196 [Source:UniProtKB/Swiss-Prot;Acc:Q8NEZ5] 5.61 7.51 1.90 3.74 1.32E-09 1.11E-07 1.68E-16 2.36E-14 2.44 4 hsa-miR-155,hsa-miR-200b,hsa-miR-221,hsa-miR-7, Uncharacterized protein C1orf43 (Hepatitis C virus NS5A- transactivated protein 4)(HCV NS5A-transactivated protein 4)(Protein C1orf43 ENSG00000143612 NICE-3)(S863-3) [Source:UniProtKB/Swiss-Prot;Acc:Q9BWL3] 7.09 9.00 1.90 3.74 2.53E-06 5.23E-05 1.61E-10 3.90E-09 1.98 1 hsa-miR-7, Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1)(NEDD-1) [Source:UniProtKB/Swiss- NEDD1 ENSG00000139350 Prot;Acc:Q8NHV4] 5.89 7.80 1.90 3.74 6.93E-06 1.18E-04 3.29E-08 4.37E-07 1.90 1 hsa-miR-200b, Tripartite motif-containing protein 25 (Zinc finger protein 147)(Estrogen-responsive finger protein)(Efp)(RING finger protein TRIM25 ENSG00000121060 147) [Source:UniProtKB/Swiss-Prot;Acc:Q14258] 6.45 8.35 1.90 3.74 8.90E-10 8.11E-08 4.50E-15 4.20E-13 1.90 1 hsa-miR-7, Clathrin heavy chain 1 (CLH-17) [Source:UniProtKB/Swiss- CLTC ENSG00000141367 Prot;Acc:Q00610] 6.67 8.57 1.90 3.74 1.80E-06 3.98E-05 2.80E-10 6.37E-09 2.32 2 hsa-miR-19a,hsa-miR-24, Protein LSM12 homolog [Source:UniProtKB/Swiss- LSM12 ENSG00000161654 Prot;Acc:Q3MHD2] 6.81 8.71 1.91 3.75 6.35E-06 1.09E-04 3.06E-08 4.10E-07 2.18 3 hsa-miR-19a,hsa-miR-27a,hsa-miR-7, Retinol dehydrogenase 11 (EC 1.1.1.-)(Retinal reductase 1)(RalR1)(Prostate short-chain dehydrogenase/reductase 1)(Androgen-regulated short-chain dehydrogenase/reductase 1)(HCV core-binding protein HCBP12) [Source:UniProtKB/Swiss- RDH11 ENSG00000072042 Prot;Acc:Q8TC12] 6.32 8.23 1.91 3.75 4.49E-06 8.31E-05 1.49E-10 3.64E-09 2.38 2 hsa-miR-365,hsa-miR-7, Ras-related protein Rab-8B [Source:UniProtKB/Swiss- RAB8B ENSG00000166128 Prot;Acc:Q92930] 7.50 9.41 1.91 3.76 3.74E-06 7.18E-05 1.91E-08 2.69E-07 1.91 3 hsa-let-7f,hsa-miR-19a,hsa-miR-218, Protein FAM3C Precursor [Source:UniProtKB/Swiss- FAM3C ENSG00000196937 Prot;Acc:Q92520] 5.76 7.67 1.92 3.78 3.15E-06 6.29E-05 3.25E-09 5.51E-08 1.92 4 hsa-miR-155,hsa-miR-18a,hsa-miR-218,hsa-miR-365, CCAAT/enhancer-binding protein gamma (C/EBP gamma) CEBPG ENSG00000153879 [Source:UniProtKB/Swiss-Prot;Acc:P53567] 6.36 8.28 1.92 3.78 2.51E-06 5.20E-05 4.71E-09 7.61E-08 1.92 1 hsa-miR-221, L-lactate dehydrogenase A chain (LDH-A)(EC 1.1.1.27)(LDH muscle subunit)(LDH-M)(Renal carcinoma antigen NY-REN-59)(Cell proliferation-inducing gene 19 protein) [Source:UniProtKB/Swiss- LDHA ENSG00000134333 Prot;Acc:P00338] 9.20 11.12 1.92 3.78 9.58E-09 5.59E-07 7.06E-14 4.58E-12 1.95 1 hsa-miR-7, Integrator complex subunit 2 (Int2) [Source:UniProtKB/Swiss- INTS2 ENSG00000108506 Prot;Acc:Q9H0H0] 5.32 7.24 1.92 3.78 2.20E-07 7.18E-06 2.92E-10 6.60E-09 1.92 1 hsa-miR-222, KIAA1279 ENSG00000198954 KIF1-binding protein [Source:UniProtKB/Swiss-Prot;Acc:Q96EK5] 5.35 7.27 1.92 3.79 3.98E-07 1.15E-05 2.27E-10 5.33E-09 2.11 1 hsa-miR-363,

snRNA-activating protein complex subunit 3 (SNAPc subunit 3)(Small nuclear RNA-activating complex polypeptide 3)(snRNA-activating protein complex 50 kDa subunit)(SNAPc 50 kDa subunit)(Proximal SNAPC3 ENSG00000164975 sequence element-binding transcription factor subunit beta)(PS 5.59 7.51 1.92 3.79 5.01E-07 1.38E-05 3.16E-10 7.09E-09 1.92 1 hsa-miR-7, ATP-binding cassette sub-family E member 1 (RNase L inhibitor)(Ribonuclease 4 inhibitor)(RNS4I)(2'-5'-oligoadenylate- binding protein)(HuHP68) [Source:UniProtKB/Swiss- ABCE1 ENSG00000164163 Prot;Acc:P61221] 6.37 8.31 1.93 3.82 8.91E-05 9.36E-04 6.10E-08 7.66E-07 2.62 2 hsa-miR-130b,hsa-miR-19a, Protein TFG (TRK-fused gene protein) [Source:UniProtKB/Swiss- TFG ENSG00000114354 Prot;Acc:Q92734] 6.25 8.19 1.93 3.82 4.61E-06 8.49E-05 6.36E-07 6.16E-06 1.93 1 hsa-miR-221, UPF0547 protein C16orf87 [Source:UniProtKB/Swiss- C16orf87 ENSG00000155330 Prot;Acc:Q6PH81] 5.35 7.29 1.94 3.83 6.14E-07 1.64E-05 5.16E-09 8.25E-08 1.94 1 hsa-miR-132, 40 kDa peptidyl-prolyl cis-trans isomerase (PPIase)(Rotamase)(EC 5.2.1.8)(Cyclophilin-40)(CYP-40)(Cyclophilin-related protein) PPID ENSG00000171497 [Source:UniProtKB/Swiss-Prot;Acc:Q08752] 5.46 7.40 1.94 3.84 2.63E-06 5.41E-05 9.92E-11 2.57E-09 2.67 1 hsa-miR-18a, Protein argonaute-2 (EC 3.1.26.n1)(Argonaute2)(hAgo2)(Protein slicer)(PAZ Piwi domain protein)(PPD)(Eukaryotic translation initiation factor 2C 2)(eIF-2C 2)(eIF2C 2) [Source:UniProtKB/Swiss- EIF2C2 ENSG00000123908 Prot;Acc:Q9UKV8] 6.58 8.53 1.94 3.84 1.15E-08 6.54E-07 1.56E-12 6.64E-11 1.94 2 hsa-miR-132,hsa-miR-27a, Calcyclin-binding protein (CacyBP)(hCacyBP)(Siah-interacting protein)(S100A6-binding protein) [Source:UniProtKB/Swiss- CACYBP ENSG00000116161 Prot;Acc:Q9HB71] 6.93 8.87 1.94 3.85 1.73E-08 9.09E-07 2.43E-13 1.34E-11 1.94 1 hsa-miR-18a, Sphingosine-1-phosphate lyase 1 (SP-lyase)(hSPL)(EC 4.1.2.27)(Sphingosine-1-phosphate aldolase) SGPL1 ENSG00000166224 [Source:UniProtKB/Swiss-Prot;Acc:O95470] 6.46 8.40 1.95 3.85 2.44E-08 1.22E-06 1.78E-13 1.03E-11 2.09 2 hsa-miR-218,hsa-miR-24, BAG family molecular chaperone regulator 2 (BAG-2)(Bcl-2- associated athanogene 2) [Source:UniProtKB/Swiss- BAG2 ENSG00000112208 Prot;Acc:O95816] 5.58 7.52 1.95 3.85 5.41E-06 9.61E-05 7.05E-10 1.44E-08 2.87 1 hsa-miR-27a,

CCND2 ENSG00000118971 G1/S-specific cyclin-D2 [Source:UniProtKB/Swiss-Prot;Acc:P30279] 6.95 8.90 1.95 3.87 1.08E-07 4.00E-06 6.93E-13 3.24E-11 2.14 6 hsa-let-7f,hsa-miR-18a,hsa-miR-19a,hsa-miR-206,hsa-miR-7,hsa-miR-93, Nucleoside diphosphate kinase A (NDP kinase A)(NDK A)(EC 2.7.4.6)(Tumor metastatic process-associated protein)(Metastasis inhibition factor nm23)(nm23-H1)(Granzyme A-activated NME1-NME2 ENSG00000011052 DNase)(GAAD) [Source:UniProtKB/Swiss-Prot;Acc:P15531] 6.53 8.49 1.96 3.88 5.51E-08 2.34E-06 7.57E-15 6.44E-13 2.63 1 hsa-miR-206, Homer protein homolog 1 [Source:UniProtKB/Swiss- HOMER1 ENSG00000152413 Prot;Acc:Q86YM7] 4.57 6.53 1.96 3.89 3.01E-07 9.22E-06 2.43E-10 5.63E-09 2.03 2 hsa-miR-19a,hsa-miR-21, 26S proteasome non-ATPase regulatory subunit 5 (26S proteasome subunit S5B)(26S protease subunit S5 basic) PSMD5 ENSG00000095261 [Source:UniProtKB/Swiss-Prot;Acc:Q16401] 5.99 7.95 1.96 3.89 8.79E-06 1.43E-04 2.97E-09 5.10E-08 2.19 1 hsa-miR-155, Protein transport protein Sec24A (SEC24-related protein A) SEC24A ENSG00000113615 [Source:UniProtKB/Swiss-Prot;Acc:O95486] 5.93 7.89 1.96 3.90 1.63E-06 3.67E-05 1.10E-07 1.29E-06 1.96 2 hsa-miR-27a,hsa-miR-7, Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15)(Ubiquitin thioesterase 37)(Ubiquitin-specific-processing protease 37)(Deubiquitinating enzyme 37) [Source:UniProtKB/Swiss- USP37 ENSG00000135913 Prot;Acc:Q86T82] 5.67 7.63 1.97 3.90 1.52E-05 2.23E-04 2.83E-07 2.99E-06 1.97 4 hsa-miR-155,hsa-miR-18a,hsa-miR-19a,hsa-miR-24, Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein)(hLrp2bp) ANKRD37 ENSG00000186352 [Source:UniProtKB/Swiss-Prot;Acc:Q7Z713] 6.12 8.08 1.97 3.91 3.50E-07 1.03E-05 1.06E-06 9.73E-06 1.97 1 hsa-miR-7, 6-phosphofructokinase type C (EC 2.7.1.11)(Phosphofructokinase 1)(Phosphohexokinase)(Phosphofructo-1-kinase isozyme C)(PFK- C)(6-phosphofructokinase, platelet type) [Source:UniProtKB/Swiss- PFKP ENSG00000067057 Prot;Acc:Q01813] 6.53 8.50 1.98 3.94 2.13E-11 4.01E-09 1.42E-16 2.03E-14 2.12 1 hsa-miR-20a, Cytotoxic and regulatory T-cell molecule Precursor (Class-I MHC- restricted T-cell-associated molecule) [Source:UniProtKB/Swiss- CRTAM ENSG00000109943 Prot;Acc:O95727] 5.16 7.15 1.99 3.97 7.06E-06 1.19E-04 8.60E-06 6.45E-05 1.99 1 hsa-miR-21, H2AFZ ENSG00000164032 Histone H2A.Z (H2A/z) [Source:UniProtKB/Swiss-Prot;Acc:P0C0S5] 8.33 10.32 1.99 3.98 7.08E-07 1.84E-05 7.37E-11 1.97E-09 2.31 1 hsa-miR-27a, Transferrin receptor protein 1 (TfR1)(TfR)(TR)(Trfr)(T9)(p90)(CD71 antigen) [Contains TFRC ENSG00000072274 Transferrin receptor protein 1, serum form(sTfR)] 6.68 8.67 2.00 3.99 3.09E-07 9.43E-06 6.03E-12 2.16E-10 2.64 3 hsa-miR-210,hsa-miR-221,hsa-miR-7, Spermatid perinuclear RNA-binding protein STRBP ENSG00000165209 [Source:UniProtKB/Swiss-Prot;Acc:Q96SI9] 5.17 7.17 2.00 3.99 1.01E-07 3.81E-06 2.14E-11 6.64E-10 2.00 1 hsa-miR-27a, Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin KIF3A ENSG00000131437 motor 3A) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y496] 4.66 6.66 2.00 4.00 6.81E-05 7.55E-04 6.26E-06 4.84E-05 2.00 5 hsa-miR-155,hsa-miR-18a,hsa-miR-19a,hsa-miR-27a,hsa-miR-365,

WD repeat and SOCS box-containing protein 2 (WSB-2)(CS box- WSB2 ENSG00000176871 containing WD protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9NYS7] 6.20 8.21 2.01 4.03 2.92E-10 3.25E-08 3.09E-18 7.68E-16 2.11 1 hsa-miR-222, RING-box protein 1 (Rbx1)(Regulator of cullins 1)(RING finger RBX1 ENSG00000100387 protein 75)(Protein ZYP) [Source:UniProtKB/Swiss-Prot;Acc:P62877] 8.25 10.26 2.02 4.04 3.30E-07 9.86E-06 5.41E-12 1.97E-10 2.36 2 hsa-miR-135b,hsa-miR-7, 39S ribosomal protein L37, mitochondrial Precursor (L37mt)(MRP- MRPL37 ENSG00000116221 L37) [Source:UniProtKB/Swiss-Prot;Acc:Q9BZE1] 6.98 9.00 2.02 4.04 1.04E-08 6.01E-07 8.12E-13 3.75E-11 2.27 1 hsa-miR-7, CD40 ligand (CD40-L)(Tumor necrosis factor ligand superfamily member 5)(TNF-related activation protein)(TRAP)(T-cell antigen Gp39)(CD154 antigen) [Contains CD40 ligand, membrane CD40LG ENSG00000102245 form;CD40 ligand, soluble form] [Source:UniProtKB/Swiss- 4.72 6.74 2.02 4.05 3.54E-05 4.39E-04 1.11E-09 2.12E-08 3.07 1 hsa-miR-24, E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-)(Neural precursor cell expressed developmentally down-regulated protein 4)(NEDD-4) NEDD4 ENSG00000069869 [Source:UniProtKB/Swiss-Prot;Acc:P46934] 4.47 6.49 2.02 4.05 2.41E-08 1.21E-06 2.28E-12 9.22E-11 2.24 3 hsa-miR-18a,hsa-miR-27a,hsa-miR-7, Protein arginine N-methyltransferase 3 (EC 2.1.1.-)(Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3) PRMT3 ENSG00000185238 [Source:UniProtKB/Swiss-Prot;Acc:O60678] 4.95 6.97 2.02 4.06 6.59E-07 1.73E-05 3.91E-12 1.49E-10 2.81 1 hsa-miR-218, Ribonuclease P protein subunit p30 (RNaseP protein p30)(EC 3.1.26.5)(RNase P subunit 2) [Source:UniProtKB/Swiss- RPP30 ENSG00000148688 Prot;Acc:P78346] 6.60 8.63 2.02 4.07 2.85E-08 1.37E-06 1.98E-13 1.13E-11 2.23 2 hsa-miR-24,hsa-miR-7, C1orf25 ENSG00000121486 TRM1-like protein [Source:UniProtKB/Swiss-Prot;Acc:Q7Z2T5] 4.69 6.72 2.03 4.07 5.14E-07 1.42E-05 1.40E-08 2.03E-07 2.08 2 hsa-miR-132,hsa-miR-135b, Microfibrillar-associated protein 1 [Source:UniProtKB/Swiss- MFAP1 ENSG00000140259 Prot;Acc:P55081] 4.94 6.96 2.03 4.08 1.00E-08 5.82E-07 1.14E-12 5.05E-11 2.38 1 hsa-miR-7, NGFI-A-binding protein 1 (EGR-1-binding protein 1)(Transcriptional NAB1 ENSG00000138386 regulatory protein p54) [Source:UniProtKB/Swiss-Prot;Acc:Q13506] 5.13 7.16 2.03 4.08 3.82E-06 7.29E-05 7.20E-08 8.88E-07 2.03 4 hsa-let-7f,hsa-miR-200b,hsa-miR-218,hsa-miR-7, Furin Precursor (EC 3.4.21.75)(Paired basic amino acid residue cleaving enzyme)(PACE)(Dibasic-processing enzyme) FURIN ENSG00000140564 [Source:UniProtKB/Swiss-Prot;Acc:P09958] 6.68 8.70 2.03 4.08 1.71E-12 5.43E-10 1.11E-18 3.35E-16 2.11 3 hsa-miR-19a,hsa-miR-20a,hsa-miR-24, ETS2 ENSG00000157557 Protein C-ets-2 [Source:UniProtKB/Swiss-Prot;Acc:P15036] 5.67 7.70 2.03 4.09 1.36E-09 1.13E-07 6.62E-13 3.12E-11 2.03 4 hsa-miR-200b,hsa-miR-218,hsa-miR-221,hsa-miR-24,

Cytochrome b5 type B Precursor (Cytochrome b5 outer mitochondrial CYB5B ENSG00000103018 membrane isoform) [Source:UniProtKB/Swiss-Prot;Acc:O43169] 7.12 9.15 2.03 4.10 4.65E-06 8.52E-05 1.48E-11 4.76E-10 2.59 2 hsa-miR-24,hsa-miR-7, DNA polymerase delta subunit 3 (DNA polymerase delta subunit p66) POLD3 ENSG00000077514 [Source:UniProtKB/Swiss-Prot;Acc:Q15054] 4.68 6.71 2.04 4.10 4.39E-07 1.24E-05 7.98E-14 5.10E-12 2.69 4 hsa-miR-132,hsa-miR-218,hsa-miR-365,hsa-miR-7, Coiled-coil domain-containing protein 6 (Protein H4)(Papillary thyroid carcinoma-encoded protein) [Source:UniProtKB/Swiss- CCDC6 ENSG00000108091 Prot;Acc:Q16204] 6.71 8.76 2.04 4.12 2.04E-06 4.40E-05 1.74E-07 1.95E-06 2.04 3 hsa-miR-19a,hsa-miR-218,hsa-miR-24, TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein TRAF1 ENSG00000056558 6) [Source:UniProtKB/Swiss-Prot;Acc:Q13077] 5.93 7.98 2.04 4.12 2.75E-09 2.01E-07 3.38E-15 3.23E-13 2.47 1 hsa-miR-24, ER degradation-enhancing alpha-mannosidase-like 1 EDEM1 ENSG00000134109 [Source:UniProtKB/Swiss-Prot;Acc:Q92611] 6.79 8.84 2.05 4.13 3.75E-07 1.10E-05 6.78E-10 1.39E-08 2.05 2 hsa-miR-155,hsa-miR-218, Hypoxia-inducible factor 1 alpha (HIF-1 alpha)(HIF1 alpha)(ARNT- interacting protein)(Member of PAS protein 1)(Basic-helix-loop-helix- HIF1A ENSG00000100644 PAS protein MOP1) [Source:UniProtKB/Swiss-Prot;Acc:Q16665] 7.20 9.25 2.05 4.14 1.90E-07 6.39E-06 2.62E-10 6.01E-09 2.15 4 hsa-miR-135b,hsa-miR-155,hsa-miR-18a,hsa-miR-20a, Lactoylglutathione lyase (EC 4.4.1.5)(Methylglyoxalase)(Aldoketomutase)(Glyoxalase I)(Glx I)(Ketone-aldehyde mutase)(S-D-lactoylglutathione methylglyoxal GLO1 ENSG00000124767 lyase) [Source:UniProtKB/Swiss-Prot;Acc:Q04760] 6.41 8.47 2.05 4.15 3.93E-06 7.46E-05 1.16E-10 2.94E-09 2.57 1 hsa-miR-7, Calnexin Precursor (Major histocompatibility complex class I antigen- binding protein p88)(p90)(IP90) [Source:UniProtKB/Swiss- CANX ENSG00000127022 Prot;Acc:P27824] 7.01 9.07 2.06 4.17 1.03E-06 2.48E-05 8.11E-11 2.14E-09 2.06 2 hsa-miR-130b,hsa-miR-7, Bcl-2-like protein 1 (Bcl2-L-1)(Apoptosis regulator Bcl-X) BCL2L1 ENSG00000171552 [Source:UniProtKB/Swiss-Prot;Acc:Q07817] 6.00 8.06 2.06 4.17 9.61E-11 1.34E-08 2.66E-17 4.93E-15 2.46 1 hsa-miR-7, Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog)(hG4-1)(ErbB3-binding protein 1) [Source:UniProtKB/Swiss- PA2G4 ENSG00000170515 Prot;Acc:Q9UQ80] 7.98 10.04 2.06 4.17 2.55E-08 1.25E-06 5.74E-16 6.76E-14 2.71 1 hsa-miR-7, UPF0364 protein C6orf211 [Source:UniProtKB/Swiss- C6orf211 ENSG00000146476 Prot;Acc:Q9H993] 4.71 6.78 2.06 4.18 5.73E-06 1.01E-04 3.89E-09 6.41E-08 2.42 1 hsa-miR-19a, Transcription factor 19 (Transcription factor SC1) TCF19 ENSG00000137310 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y242] 5.99 8.06 2.07 4.20 1.63E-10 2.01E-08 1.92E-15 1.93E-13 2.57 3 hsa-miR-210,hsa-miR-218,hsa-miR-7, Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6)(Glucosamine-6- phosphate deaminase 1)(GlcN6P deaminase 1)(GNPDA 1)(Oscillin) GNPDA1 ENSG00000113552 [Source:UniProtKB/Swiss-Prot;Acc:P46926] 5.73 7.81 2.08 4.21 1.92E-09 1.49E-07 7.02E-16 8.08E-14 2.81 2 hsa-miR-200b,hsa-miR-7, DNA-damage-inducible transcript 4 protein (Protein regulated in development and DNA damage response 1)(REDD-1)(HIF-1 responsive protein RTP801) [Source:UniProtKB/Swiss- DDIT4 ENSG00000168209 Prot;Acc:Q9NX09] 7.67 9.75 2.08 4.22 5.32E-07 1.46E-05 1.64E-08 2.34E-07 2.08 3 hsa-miR-200b,hsa-miR-221,hsa-miR-7, WD repeat and SOCS box-containing protein 1 (WSB-1)(SOCS box- containing WD protein SWiP-1) [Source:UniProtKB/Swiss- WSB1 ENSG00000109046 Prot;Acc:Q9Y6I7] 6.65 8.74 2.09 4.26 3.33E-05 4.19E-04 2.51E-06 2.13E-05 2.09 1 hsa-miR-27a, Proteasome subunit alpha type-4 (EC 3.4.25.1)(Proteasome component C9)(Macropain subunit C9)(Multicatalytic endopeptidase complex subunit C9)(Proteasome subunit L) [Source:UniProtKB/Swiss- PSMA4 ENSG00000041357 Prot;Acc:P25789] 6.73 8.83 2.10 4.29 8.37E-06 1.37E-04 2.41E-10 5.61E-09 2.70 1 hsa-miR-7, 3'-5' exoribonuclease CSL4 homolog (EC 3.1.13.-)(Exosome EXOSC1 ENSG00000171311 component 1) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y3B2] 6.07 8.17 2.10 4.30 1.20E-05 1.84E-04 4.62E-09 7.49E-08 2.59 1 hsa-miR-7, Exportin-5 (Exp5)(Ran-binding protein 21) [Source:UniProtKB/Swiss- XPO5 ENSG00000124571 Prot;Acc:Q9HAV4] 5.75 7.86 2.10 4.30 4.78E-10 4.88E-08 8.34E-16 9.49E-14 2.43 2 hsa-miR-218,hsa-miR-24, Signal transducer and activator of transcription 3 (Acute-phase STAT3 ENSG00000168610 response factor) [Source:UniProtKB/Swiss-Prot;Acc:P40763] 8.25 10.36 2.11 4.31 1.80E-07 6.07E-06 1.71E-09 3.13E-08 2.11 3 hsa-miR-130b,hsa-miR-21,hsa-miR-222, Protein sprouty homolog 1 (Spry-1) [Source:UniProtKB/Swiss- SPRY1 ENSG00000164056 Prot;Acc:O43609] 6.04 8.15 2.11 4.31 3.40E-09 2.40E-07 2.47E-09 4.31E-08 2.11 1 hsa-miR-132, Armadillo repeat-containing protein 1 [Source:UniProtKB/Swiss- ARMC1 ENSG00000104442 Prot;Acc:Q9NVT9] 6.46 8.57 2.11 4.31 4.91E-06 8.91E-05 9.40E-10 1.84E-08 2.39 2 hsa-miR-132,hsa-miR-210, 14-3-3 protein epsilon (14-3-3E) [Source:UniProtKB/Swiss- YWHAE ENSG00000108953 Prot;Acc:P62258] 6.88 8.99 2.11 4.31 1.77E-07 6.00E-06 8.64E-13 3.95E-11 2.40 2 hsa-miR-155,hsa-miR-29b, Early growth response protein 3 (EGR-3)(Zinc finger protein pilot) EGR3 ENSG00000179388 [Source:UniProtKB/Swiss-Prot;Acc:Q06889] 5.15 7.26 2.11 4.32 1.05E-08 6.03E-07 2.44E-09 4.27E-08 2.11 3 hsa-miR-19a,hsa-miR-21,hsa-miR-27a, Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase TDP1 ENSG00000042088 1)(EC 3.1.4.-) [Source:UniProtKB/Swiss-Prot;Acc:Q9NUW8] 6.13 8.25 2.12 4.34 3.56E-07 1.05E-05 1.95E-10 4.64E-09 2.17 2 hsa-miR-18a,hsa-miR-218, Myotubularin-related protein 2 (EC 3.1.3.-) [Source:UniProtKB/Swiss- MTMR2 ENSG00000087053 Prot;Acc:Q13614] 5.81 7.93 2.12 4.35 8.86E-09 5.23E-07 7.88E-14 5.05E-12 2.45 1 hsa-miR-222, Mitochondrial import inner membrane translocase subunit Tim9 TIMM9 ENSG00000100575 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5J7] 5.18 7.30 2.12 4.35 1.78E-04 1.66E-03 1.80E-05 1.25E-04 2.12 1 hsa-miR-132, Stathmin (Phosphoprotein p19)(pp19)(Leukemia-associated phosphoprotein p18)(Oncoprotein 18)(Op18)(pp17)(Prosolin)(Metablastin)(Protein Pr22) STMN1 ENSG00000117632 [Source:UniProtKB/Swiss-Prot;Acc:P16949] 6.21 8.33 2.12 4.36 1.50E-10 1.87E-08 1.36E-16 1.98E-14 2.16 2 hsa-miR-132,hsa-miR-222, StAR-related lipid transfer protein 4 (START domain-containing STARD4 ENSG00000164211 protein 4)(StARD4) [Source:UniProtKB/Swiss-Prot;Acc:Q96DR4] 5.72 7.84 2.12 4.36 1.87E-07 6.30E-06 3.46E-09 5.81E-08 2.15 2 hsa-miR-18a,hsa-miR-365, Voltage-dependent anion-selective channel protein 1 (VDAC- 1)(hVDAC1)(Outer mitochondrial membrane protein porin 1)(Plasmalemmal porin)(Porin 31HL)(Porin 31HM) VDAC1 ENSG00000213585 [Source:UniProtKB/Swiss-Prot;Acc:P21796] 7.37 9.50 2.13 4.36 7.08E-09 4.37E-07 2.51E-14 1.83E-12 2.41 1 hsa-miR-7, Transcription factor ETV6 (ETS translocation variant 6)(ETS-related ETV6 ENSG00000139083 protein Tel1)(Tel) [Source:UniProtKB/Swiss-Prot;Acc:P41212] 5.92 8.05 2.13 4.37 7.07E-08 2.84E-06 7.52E-11 2.00E-09 2.13 2 hsa-miR-18a,hsa-miR-7, DNA repair protein RAD50 (hRAD50)(EC 3.6.-.-) RAD50 ENSG00000113522 [Source:UniProtKB/Swiss-Prot;Acc:Q92878] 5.86 7.99 2.13 4.39 2.49E-06 5.17E-05 5.90E-09 9.33E-08 2.13 1 hsa-miR-206, FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1)(FACT 80 kDa subunit)(FACTp80)(Chromatin-specific transcription elongation factor 80 kDa subunit)(Structure-specific recognition protein SSRP1 ENSG00000149136 1)(hSSRP1)(Recombination signal 6.68 8.82 2.13 4.39 5.46E-09 3.56E-07 3.78E-15 3.57E-13 2.24 1 hsa-miR-424, Myb proto-oncogene protein (C-myb) [Source:UniProtKB/Swiss- MYB ENSG00000118513 Prot;Acc:P10242] 5.10 7.24 2.14 4.39 6.54E-08 2.69E-06 1.25E-09 2.37E-08 2.14 3 hsa-miR-155,hsa-miR-200b,hsa-miR-424, 4F2 cell-surface antigen heavy chain (4F2hc)(Lymphocyte activation antigen 4F2 large subunit)(4F2 heavy chain antigen)(CD98 antigen) SLC3A2 ENSG00000168003 [Source:UniProtKB/Swiss-Prot;Acc:P08195] 7.33 9.47 2.14 4.40 4.01E-09 2.73E-07 9.06E-16 1.02E-13 2.28 1 hsa-miR-7, Insulin-induced gene 2 protein (INSIG-2) [Source:UniProtKB/Swiss- INSIG2 ENSG00000125629 Prot;Acc:Q9Y5U4] 6.90 9.04 2.15 4.42 3.86E-07 1.12E-05 2.08E-07 2.29E-06 2.15 3 hsa-miR-155,hsa-miR-19a,hsa-miR-7, T-complex protein 1 subunit delta (TCP-1-delta)(CCT- delta)(Stimulator of TAR RNA-binding) [Source:UniProtKB/Swiss- CCT4 ENSG00000115484 Prot;Acc:P50991] 7.37 9.52 2.15 4.43 1.11E-06 2.67E-05 6.32E-11 1.72E-09 2.53 1 hsa-miR-7, Ras-related protein Rab-27A (Rab-27)(GTP-binding protein Ram) RAB27A ENSG00000069974 [Source:UniProtKB/Swiss-Prot;Acc:P51159] 7.24 9.39 2.15 4.43 2.23E-07 7.26E-06 1.36E-13 8.12E-12 2.26 1 hsa-miR-29b, Signaling lymphocytic activation molecule Precursor (IPO- 3)(CDw150)(CD150 antigen) [Source:UniProtKB/Swiss- SLAMF1 ENSG00000117090 Prot;Acc:Q13291] 5.42 7.57 2.16 4.46 1.49E-08 8.11E-07 3.40E-12 1.32E-10 2.35 2 hsa-miR-221,hsa-miR-7, E3 ubiquitin-protein ligase RNF19A (EC 6.3.2.-)(RING finger protein 19A)(Double ring-finger protein)(Dorfin)(p38) RNF19A ENSG00000034677 [Source:UniProtKB/Swiss-Prot;Acc:Q9NV58] 7.41 9.58 2.16 4.48 6.76E-09 4.26E-07 5.39E-13 2.61E-11 2.16 4 hsa-miR-155,hsa-miR-19a,hsa-miR-200b,hsa-miR-7, GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein)(RAS-like protein KIR) [Source:UniProtKB/Swiss- GEM ENSG00000164949 Prot;Acc:P55040] 4.84 7.01 2.17 4.50 1.22E-05 1.86E-04 1.69E-05 1.18E-04 2.17 1 hsa-miR-27a, Ras-related GTP-binding protein D (Rag D)(RagD) RRAGD ENSG00000025039 [Source:UniProtKB/Swiss-Prot;Acc:Q9NQL2] 5.09 7.27 2.18 4.52 4.12E-07 1.18E-05 2.09E-09 3.73E-08 2.18 1 hsa-miR-130b, Retinol dehydrogenase 10 (EC 1.1.1.n2) [Source:UniProtKB/Swiss- RDH10 ENSG00000121039 Prot;Acc:Q8IZV5] 5.17 7.36 2.19 4.55 2.00E-10 2.35E-08 1.71E-15 1.75E-13 2.84 2 hsa-miR-200b,hsa-miR-98, Apoptosis regulator Bcl-2 [Source:UniProtKB/Swiss- BCL2 ENSG00000171791 Prot;Acc:P10415] 7.63 9.81 2.19 4.55 1.35E-05 2.02E-04 3.08E-07 3.22E-06 2.19 4 hsa-miR-155,hsa-miR-200b,hsa-miR-365,hsa-miR-7, Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1)(Transcription elongation factor TFIIS.o) TCEA1 ENSG00000187735 [Source:UniProtKB/Swiss-Prot;Acc:P23193] 7.87 10.06 2.19 4.56 1.35E-07 4.83E-06 1.03E-12 4.60E-11 2.19 1 hsa-miR-19b, Reticulocalbin-1 Precursor [Source:UniProtKB/Swiss- RCN1 ENSG00000049449 Prot;Acc:Q15293] 5.82 8.02 2.19 4.57 1.48E-08 8.09E-07 4.24E-13 2.15E-11 2.25 1 hsa-miR-132, Adenylate kinase 2, mitochondrial (AK 2)(EC 2.7.4.3)(ATP-AMP AK2 ENSG00000004455 transphosphorylase 2) [Source:UniProtKB/Swiss-Prot;Acc:P54819] 6.69 8.88 2.19 4.58 2.26E-08 1.14E-06 9.02E-14 5.65E-12 2.42 3 hsa-miR-155,hsa-miR-27a,hsa-miR-365, Exportin-2 (Exp2)(Importin-alpha re-exporter)(Chromosome segregation 1-like protein)(Cellular apoptosis susceptibility protein) CSE1L ENSG00000124207 [Source:UniProtKB/Swiss-Prot;Acc:P55060] 5.95 8.15 2.20 4.59 3.84E-07 1.11E-05 6.59E-13 3.11E-11 3.15 1 hsa-miR-155, U6 snRNA-associated Sm-like protein LSm3 LSM3 ENSG00000170860 [Source:UniProtKB/Swiss-Prot;Acc:P62310] 6.60 8.80 2.20 4.60 1.52E-05 2.22E-04 3.78E-08 4.95E-07 2.56 2 hsa-miR-21,hsa-miR-7, GPI inositol-deacylase (EC 3.1.-.-)(Post-GPI attachment to proteins PGAP1 ENSG00000197121 factor 1)(hPGAP1) [Source:UniProtKB/Swiss-Prot;Acc:Q75T13] 4.96 7.16 2.20 4.60 7.10E-08 2.85E-06 6.43E-10 1.33E-08 2.20 2 hsa-miR-155,hsa-miR-27a, Kinesin-like protein KIF2A (Kinesin-2)(HK2) KIF2A ENSG00000068796 [Source:UniProtKB/Swiss-Prot;Acc:O00139] 6.92 9.13 2.21 4.62 1.93E-05 2.71E-04 2.77E-07 2.94E-06 2.21 1 hsa-miR-218, DNA-damage-inducible transcript 4-like protein (Protein regulated in development and DNA damage response 2)(REDD-2)(HIF-1 responsive protein RTP801-like) [Source:UniProtKB/Swiss- DDIT4L ENSG00000145358 Prot;Acc:Q96D03] 3.83 6.05 2.22 4.66 5.26E-06 9.38E-05 1.74E-06 1.52E-05 2.22 2 hsa-miR-200b,hsa-miR-7, Replication factor C subunit 5 (Activator 1 subunit 5)(Replication factor C 36 kDa subunit)(RF-C 36 kDa subunit)(RFC36)(Activator 1 36 kDa subunit)(A1 36 kDa subunit) [Source:UniProtKB/Swiss- RFC5 ENSG00000111445 Prot;Acc:P40937] 4.89 7.12 2.22 4.67 2.92E-08 1.39E-06 2.63E-14 1.91E-12 2.79 1 hsa-miR-7, DnaJ homolog subfamily C member 12 (J domain-containing protein DNAJC12 ENSG00000108176 1) [Source:UniProtKB/Swiss-Prot;Acc:Q9UKB3] 4.67 6.90 2.23 4.68 6.72E-10 6.38E-08 3.07E-17 5.58E-15 3.81 1 hsa-miR-7, Borealin (Dasra-B)(hDasra-B)(Cell division cycle-associated protein 8)(Pluripotent embryonic stem cell-related gene 3 protein) CDCA8 ENSG00000134690 [Source:UniProtKB/Swiss-Prot;Acc:Q53HL2] 4.82 7.06 2.25 4.74 1.14E-13 5.90E-11 1.59E-18 4.43E-16 2.25 1 hsa-miR-21, Nuclear factor erythroid 2-related factor 1 (NF-E2-related factor 1)(NFE2-related factor 1)(Nuclear factor, erythroid derived 2, like 1)(Transcription factor 11)(Transcription factor NFE2L1 ENSG00000082641 HBZ17)(Transcription factor LCR-F1)(Locus control region-factor 1) 6.18 8.43 2.25 4.74 1.36E-09 1.13E-07 1.44E-15 1.50E-13 2.29 1 hsa-miR-218, Rho GTPase-activating protein 19 (Rho-type GTPase-activating ARHGAP19 ENSG00000213390 protein 19) [Source:UniProtKB/Swiss-Prot;Acc:Q14CB8] 4.99 7.24 2.25 4.76 1.01E-07 3.80E-06 3.88E-10 8.54E-09 2.25 1 hsa-miR-24, DNA repair protein RAD51 homolog 3 (R51H3)(RAD51-like protein RAD51C ENSG00000108384 2) [Source:UniProtKB/Swiss-Prot;Acc:O43502] 4.88 7.14 2.26 4.79 1.38E-09 1.14E-07 8.22E-15 6.86E-13 2.70 1 hsa-miR-155, Ras-related protein Rab-39B [Source:UniProtKB/Swiss- RAB39B ENSG00000155961 Prot;Acc:Q96DA2] 4.94 7.21 2.27 4.81 1.94E-07 6.48E-06 1.06E-09 2.04E-08 2.27 1 hsa-miR-19a, Polycomb protein EED (hEED)(WD protein associating with integrin cytoplasmic tails 1)(WAIT-1) [Source:UniProtKB/Swiss- EED ENSG00000074266 Prot;Acc:O75530] 6.53 8.79 2.27 4.82 3.72E-09 2.58E-07 2.52E-15 2.46E-13 2.77 1 hsa-miR-7, Phosphoglycerate kinase 1 (EC 2.7.2.3)(Primer recognition protein 2)(PRP 2)(Cell migration-inducing gene 10 protein) PGK1 ENSG00000102144 [Source:UniProtKB/Swiss-Prot;Acc:P00558] 7.19 9.46 2.27 4.83 7.77E-08 3.07E-06 4.32E-10 9.36E-09 2.27 1 hsa-miR-365, V-type proton ATPase 116 kDa subunit a isoform 2 (V-ATPase 116 kDa isoform a2)(Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)(Lysosomal H(+)-transporting ATPase V0 subunit ATP6V0A2 ENSG00000185344 a2)(TJ6) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y487] 6.26 8.54 2.28 4.85 1.25E-09 1.05E-07 6.91E-16 7.99E-14 2.46 1 hsa-miR-24, Forkhead box protein M1 (Forkhead-related protein FKHL16)(Hepatocyte nuclear factor 3 forkhead homolog 11)(HNF- 3/fork-head homolog 11)(HFH-11)(Winged-helix factor from INS-1 cells)(M-phase phosphoprotein 2)(MPM-2 reactive phosphoprotein FOXM1 ENSG00000111206 2)(Transcription f 5.25 7.53 2.28 4.85 1.21E-13 6.18E-11 3.04E-18 7.64E-16 2.28 1 hsa-miR-7, snRNA-activating protein complex subunit 1 (SNAPc subunit 1)(snRNA-activating protein complex 43 kDa subunit)(SNAPc 43 kDa subunit)(Small nuclear RNA-activating complex polypeptide 1)(Proximal sequence element-binding transcription factor subunit SNAPC1 ENSG00000023608 g amma)(P 5.82 8.10 2.28 4.85 4.00E-08 1.78E-06 5.19E-12 1.90E-10 2.28 2 hsa-miR-200b,hsa-miR-363, High affinity cationic amino acid transporter 1 (CAT- 1)(CAT1)(System Y+ basic amino acid transporter)(Solute carrier family 7 member 1)(Ecotropic retroviral leukemia receptor homolog)(Ecotropic retrovirus receptor homolog)(ERR) SLC7A1 ENSG00000139514 [Source:UniProtKB/Swiss-Pro 6.12 8.40 2.28 4.86 1.58E-14 1.42E-11 2.99E-20 1.81E-17 2.28 1 hsa-miR-24, Voltage-dependent anion-selective channel protein 3 (VDAC- 3)(hVDAC3)(Outer mitochondrial membrane protein porin 3) VDAC3 ENSG00000078668 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y277] 6.92 9.20 2.28 4.86 2.13E-05 2.92E-04 2.79E-08 3.78E-07 2.52 2 hsa-miR-27a,hsa-miR-7, Tetratricopeptide repeat protein 9C (TPR repeat protein 9C) TTC9C ENSG00000162222 [Source:UniProtKB/Swiss-Prot;Acc:Q8N5M4] 5.59 7.88 2.28 4.87 5.75E-08 2.42E-06 5.87E-11 1.62E-09 2.28 1 hsa-miR-24, Interleukin-23 receptor Precursor (IL-23R) [Source:UniProtKB/Swiss- IL23R ENSG00000162594 Prot;Acc:Q5VWK5] 4.62 6.90 2.28 4.87 1.44E-09 1.18E-07 2.77E-12 1.09E-10 2.54 1 hsa-miR-155, RING1 and YY1-binding protein (Death effector domain-associated factor)(DED-associated factor)(YY1 and E4TF1-associated factor 1)(Apoptin-associating protein 1)(APAP-1) [Source:UniProtKB/Swiss- RYBP ENSG00000163602 Prot;Acc:Q8N488] 5.95 8.24 2.29 4.90 6.92E-07 1.81E-05 4.34E-10 9.40E-09 2.29 5 hsa-miR-130b,hsa-miR-21,hsa-miR-218,hsa-miR-27a,hsa-miR-7, Amidophosphoribosyltransferase Precursor (ATase)(EC 2.4.2.14)(Glutamine phosphoribosylpyrophosphate amidotransferase)(GPAT) [Source:UniProtKB/Swiss- PPAT ENSG00000128059 Prot;Acc:Q06203] 5.02 7.32 2.30 4.92 1.01E-07 3.80E-06 4.58E-13 2.28E-11 3.08 2 hsa-miR-132,hsa-miR-7, Transcription factor E2F8 (E2F-8) [Source:UniProtKB/Swiss- E2F8 ENSG00000129173 Prot;Acc:A0AVK6] 4.25 6.55 2.30 4.93 2.17E-10 2.50E-08 1.00E-14 8.24E-13 2.30 1 hsa-miR-19a, BET1 homolog (hBET1)(Golgi vesicular membrane-trafficking protein BET1 ENSG00000105829 p18) [Source:UniProtKB/Swiss-Prot;Acc:O15155] 5.70 8.01 2.30 4.93 8.47E-07 2.14E-05 3.40E-09 5.74E-08 2.30 2 hsa-miR-132,hsa-miR-155, Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit)(CPSF 25 kDa subunit)(Pre-mRNA cleavage factor Im 25 kDa subunit)(Nucleoside NUDT21 ENSG00000167005 diphosphate-linked moiety X motif 21)(Nudix motif 21) [S 6.91 9.22 2.31 4.97 2.62E-08 1.28E-06 1.04E-13 6.37E-12 2.37 4 hsa-miR-18a,hsa-miR-222,hsa-miR-24,hsa-miR-7, COPG2 ENSG00000214133 4.94 7.25 2.31 4.97 1.03E-05 1.62E-04 3.90E-08 5.09E-07 2.31 1 hsa-miR-24, Origin recognition complex subunit 6 [Source:UniProtKB/Swiss- ORC6L ENSG00000091651 Prot;Acc:Q9Y5N6] 4.12 6.45 2.32 5.01 4.29E-09 2.88E-07 1.07E-14 8.74E-13 2.97 1 hsa-miR-155, Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1)(Tyrosyl--tRNA YARS ENSG00000134684 ligase)(TyrRS) [Source:UniProtKB/Swiss-Prot;Acc:P54577] 6.34 8.67 2.32 5.01 6.81E-09 4.26E-07 3.92E-14 2.73E-12 2.32 1 hsa-miR-7, Coiled-coil domain-containing protein 47 Precursor CCDC47 ENSG00000108588 [Source:UniProtKB/Swiss-Prot;Acc:Q96A33] 6.09 8.42 2.33 5.02 1.44E-08 7.95E-07 3.10E-13 1.62E-11 2.42 2 hsa-miR-19a,hsa-miR-424, Cystine/glutamate transporter (Amino acid transport system xc- )(xCT)(Solute carrier family 7 member 11)(Calcium channel blocker resistance protein CCBR1) [Source:UniProtKB/Swiss- SLC7A11 ENSG00000151012 Prot;Acc:Q9UPY5] 4.44 6.77 2.33 5.03 1.34E-09 1.12E-07 9.74E-16 1.09E-13 2.51 2 hsa-miR-155,hsa-miR-27a, Cell division cycle-associated 7-like protein (Protein JPO2)(Transcription factor RAM2) [Source:UniProtKB/Swiss- CDCA7L ENSG00000164649 Prot;Acc:Q96GN5] 5.47 7.80 2.33 5.04 5.75E-08 2.42E-06 2.94E-11 8.76E-10 2.46 1 hsa-miR-218, Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase)(HGPRT)(EC 2.4.2.8) [Source:UniProtKB/Swiss- HPRT1 ENSG00000165704 Prot;Acc:P00492] 6.36 8.70 2.34 5.05 1.52E-07 5.32E-06 2.05E-12 8.47E-11 2.67 1 hsa-miR-19a, T-complex protein 1 subunit epsilon (TCP-1-epsilon)(CCT-epsilon) CCT5 ENSG00000150753 [Source:UniProtKB/Swiss-Prot;Acc:P48643] 6.22 8.56 2.34 5.06 2.79E-08 1.34E-06 2.47E-14 1.81E-12 3.24 2 hsa-miR-18a,hsa-miR-7, Importin-5 (Imp5)(Importin subunit beta-3)(Karyopherin beta-3)(Ran- binding protein 5)(RanBP5) [Source:UniProtKB/Swiss- IPO5 ENSG00000065150 Prot;Acc:O00410] 5.89 8.23 2.34 5.08 2.77E-08 1.33E-06 2.16E-13 1.22E-11 2.57 2 hsa-miR-21,hsa-miR-7, Mitochondrial import receptor subunit TOM34 (hTom34)(Translocase of outer membrane 34 kDa subunit) [Source:UniProtKB/Swiss- TOMM34 ENSG00000025772 Prot;Acc:Q15785] 5.83 8.18 2.34 5.08 7.69E-09 4.68E-07 2.15E-12 8.81E-11 2.50 2 hsa-miR-155,hsa-miR-24, Cytoskeleton-associated protein 5 (Colonic and hepatic tumor over- expressed protein)(Ch-TOG protein) [Source:UniProtKB/Swiss- CKAP5 ENSG00000175216 Prot;Acc:Q14008] 4.90 7.25 2.35 5.10 3.26E-08 1.52E-06 4.29E-11 1.23E-09 2.35 1 hsa-miR-155, Uncharacterized protein C6orf167 [Source:UniProtKB/Swiss- C6orf167 ENSG00000146263 Prot;Acc:Q6ZRQ5] 4.50 6.85 2.35 5.11 1.43E-07 5.07E-06 9.82E-13 4.39E-11 2.83 2 hsa-miR-155,hsa-miR-7, Transmembrane protein 106C (Endoplasmic reticulum membrane protein overexpressed in cancer) [Source:UniProtKB/Swiss- TMEM106C ENSG00000134291 Prot;Acc:Q9BVX2] 6.38 8.73 2.36 5.13 1.13E-08 6.46E-07 1.71E-13 9.98E-12 2.60 1 hsa-miR-7, Peptidyl-glycine alpha-amidating monooxygenase Precursor (PAM) [Includes Peptidylglycine alpha-hydroxylating monooxygenase(PHM)(EC 1.14.17.3);Peptidyl-alpha-hydroxyglycine alpha-amidating lyase(EC 4.3.2.5)(Peptidylamidoglycolate PAM ENSG00000145730 lyase)(PAL)] [Source:UniPr 4.98 7.33 2.36 5.13 4.70E-08 2.04E-06 8.20E-09 1.26E-07 2.36 2 hsa-miR-132,hsa-miR-424, General transcription factor IIH subunit 3 (General transcription factor IIH polypeptide 3)(TFIIH basal transcription factor complex p34 subunit)(Basic transcription factor 2 34 kDa subunit)(BTF2-p34) GTF2H3 ENSG00000111358 [Source:UniProtKB/Swiss-Prot;Acc:Q13889] 4.73 7.09 2.36 5.14 1.62E-06 3.66E-05 8.14E-11 2.14E-09 2.87 2 hsa-miR-155,hsa-miR-365, Protein Mis18-beta (Opa-interacting protein 5)(Cancer/testis antigen OIP5 ENSG00000104147 86)(CT86) [Source:UniProtKB/Swiss-Prot;Acc:O43482] 4.40 6.77 2.37 5.16 1.69E-13 8.19E-11 4.27E-19 1.54E-16 2.56 1 hsa-miR-424, Coronin-1C (Coronin-3)(hCRNN4) [Source:UniProtKB/Swiss- CORO1C ENSG00000110880 Prot;Acc:Q9ULV4] 5.96 8.34 2.37 5.19 8.72E-09 5.16E-07 6.74E-13 3.17E-11 2.82 2 hsa-miR-200b,hsa-miR-21, ATP-binding cassette sub-family D member 3 (70 kDa peroxisomal membrane protein)(PMP70) [Source:UniProtKB/Swiss- ABCD3 ENSG00000117528 Prot;Acc:P28288] 5.30 7.68 2.38 5.21 6.54E-08 2.69E-06 6.94E-13 3.24E-11 3.03 1 hsa-miR-19a, Breast cancer type 1 susceptibility protein (EC 6.3.2.-)(RING finger BRCA1 ENSG00000012048 protein 53) [Source:UniProtKB/Swiss-Prot;Acc:P38398] 4.52 6.91 2.38 5.22 2.70E-12 7.61E-10 1.73E-18 4.78E-16 2.60 3 hsa-miR-132,hsa-miR-218,hsa-miR-7, DNA cross-link repair 1A protein (hSNM1A)(hSNM1) DCLRE1A ENSG00000198924 [Source:UniProtKB/Swiss-Prot;Acc:Q6PJP8] 4.10 6.49 2.39 5.25 4.91E-09 3.26E-07 2.71E-12 1.07E-10 2.43 2 hsa-miR-155,hsa-miR-222, Aspartate aminotransferase, cytoplasmic (EC 2.6.1.1)(Transaminase A)(Glutamate oxaloacetate transaminase 1) [Source:UniProtKB/Swiss- GOT1 ENSG00000120053 Prot;Acc:P17174] 5.70 8.10 2.39 5.26 5.84E-10 5.73E-08 5.86E-15 5.25E-13 2.47 2 hsa-miR-155,hsa-miR-365, RDX ENSG00000137710 Radixin [Source:UniProtKB/Swiss-Prot;Acc:P35241] 4.88 7.28 2.40 5.27 2.10E-07 6.95E-06 2.61E-10 6.00E-09 2.40 1 hsa-miR-221, Uncharacterized protein C15orf42 [Source:UniProtKB/Swiss- C15orf42 ENSG00000140534 Prot;Acc:Q7Z2Z1] 4.58 6.98 2.40 5.27 8.35E-11 1.20E-08 5.65E-17 9.03E-15 2.40 1 hsa-miR-24, Hepatitis A virus cellular receptor 2 Precursor (HAVcr-2)(T-cell immunoglobulin and mucin domain-containing protein 3)(TIMD-3)(T- cell membrane protein 3)(TIM-3) [Source:UniProtKB/Swiss- HAVCR2 ENSG00000135077 Prot;Acc:Q8TDQ0] 5.69 8.09 2.40 5.27 8.40E-10 7.75E-08 1.64E-11 5.22E-10 2.40 1 hsa-miR-18a, Protein FAM60A (Tera protein homolog) [Source:UniProtKB/Swiss- FAM60A ENSG00000139146 Prot;Acc:Q9NP50] 6.49 8.89 2.40 5.28 3.43E-07 1.02E-05 1.41E-10 3.48E-09 2.40 5 hsa-miR-106b,hsa-miR-155,hsa-miR-200b,hsa-miR-365,hsa-miR-424, Cell division protein kinase 6 (EC 2.7.11.22)(Serine/threonine-protein hsa-miR-132,hsa-miR-21,hsa-miR-218,hsa-miR-221,hsa-miR-27a,hsa-miR-424,hsa- CDK6 ENSG00000105810 kinase PLSTIRE) [Source:UniProtKB/Swiss-Prot;Acc:Q00534] 6.12 8.53 2.40 5.28 1.67E-07 5.73E-06 4.52E-12 1.69E-10 2.40 7 miR-7, Centromere protein R (CENP-R)(Nuclear receptor-interacting factor 3)(Integrin beta-3-binding protein)(Beta3-endonexin) ITGB3BP ENSG00000142856 [Source:UniProtKB/Swiss-Prot;Acc:Q13352] 5.05 7.47 2.42 5.34 3.69E-06 7.12E-05 6.38E-10 1.32E-08 2.68 1 hsa-miR-155, Guanine nucleotide-binding protein subunit alpha-15 (G-protein subunit alpha-15)(G alpha-15)(Guanine nucleotide-binding protein subunit alpha-16)(G-protein subunit alpha-16)(G alpha-16) GNA15 ENSG00000060558 [Source:UniProtKB/Swiss-Prot;Acc:P30679] 5.43 7.85 2.42 5.35 1.76E-09 1.39E-07 2.23E-10 5.24E-09 2.42 1 hsa-miR-210, Probable cation-transporting ATPase 13A3 (EC 3.6.3.-)(ATPase family homolog up-regulated in senescence cells 1) ATP13A3 ENSG00000133657 [Source:UniProtKB/Swiss-Prot;Acc:Q9H7F0] 5.95 8.37 2.43 5.38 7.98E-08 3.13E-06 2.74E-12 1.08E-10 2.74 4 hsa-miR-130b,hsa-miR-27a,hsa-miR-365,hsa-miR-7, Lymphotoxin-alpha Precursor (LT-alpha)(TNF-beta)(Tumor necrosis factor ligand superfamily member 1) [Source:UniProtKB/Swiss- LTA ENSG00000226979 Prot;Acc:P01374] 6.32 8.76 2.43 5.40 6.38E-13 2.36E-10 1.44E-19 6.53E-17 3.04 1 hsa-miR-7, Fidgetin-like protein 1 (EC 3.6.4.-) [Source:UniProtKB/Swiss- FIGNL1 ENSG00000132436 Prot;Acc:Q6PIW4] 4.67 7.12 2.45 5.46 2.43E-09 1.81E-07 5.73E-12 2.07E-10 2.45 1 hsa-miR-7, Zinc finger protein 382 (Multiple zinc finger and krueppel-associated box protein KS1)(KRAB/zinc finger suppressor protein 1)(KS1) ZNF382 ENSG00000161298 [Source:UniProtKB/Swiss-Prot;Acc:Q96SR6] 3.83 6.29 2.45 5.47 2.29E-05 3.09E-04 9.12E-07 8.50E-06 2.45 1 hsa-miR-7, 60S ribosomal protein L22-like 1 [Source:UniProtKB/Swiss- RPL22L1 ENSG00000163584 Prot;Acc:Q6P5R6] 6.17 8.63 2.46 5.52 1.47E-06 3.39E-05 5.34E-10 1.12E-08 2.73 1 hsa-miR-155, Pseudouridylate synthase 7 homolog (EC 5.4.99.-) PUS7 ENSG00000091127 [Source:UniProtKB/Swiss-Prot;Acc:Q96PZ0] 3.93 6.40 2.47 5.53 2.67E-08 1.30E-06 2.58E-13 1.40E-11 3.24 1 hsa-miR-155, Nucleoporin p58/p45 (Nucleoporin-like 1) [Source:UniProtKB/Swiss- NUPL1 ENSG00000139496 Prot;Acc:Q9BVL2] 5.94 8.42 2.48 5.58 6.67E-09 4.22E-07 2.41E-13 1.33E-11 2.54 3 hsa-miR-132,hsa-miR-18a,hsa-miR-222, ATP-binding cassette sub-family B member 7, mitochondrial Precursor (ATP-binding cassette transporter 7)(ABC transporter 7 ABCB7 ENSG00000131269 protein) [Source:UniProtKB/Swiss-Prot;Acc:O75027] 5.92 8.40 2.48 5.60 6.57E-06 1.12E-04 1.67E-07 1.88E-06 2.48 1 hsa-miR-19a, Cell division protein kinase 2 (EC 2.7.11.22)(p33 protein kinase) CDK2 ENSG00000123374 [Source:UniProtKB/Swiss-Prot;Acc:P24941] 5.44 7.93 2.49 5.62 7.40E-11 1.09E-08 4.46E-15 4.17E-13 2.89 2 hsa-miR-18a,hsa-miR-200b, Sorting nexin-9 (SH3 and PX domain-containing protein 1)(Protein SDP1)(SH3 and PX domain-containing protein 3A) SNX9 ENSG00000130340 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5X1] 6.34 8.83 2.49 5.62 1.95E-08 1.01E-06 5.78E-12 2.09E-10 2.49 1 hsa-miR-7, OX-2 membrane glycoprotein Precursor (CD200 antigen) CD200 ENSG00000091972 [Source:UniProtKB/Swiss-Prot;Acc:P41217] 4.71 7.21 2.50 5.65 1.33E-10 1.71E-08 5.03E-13 2.47E-11 2.54 1 hsa-miR-98, Interferon regulatory factor 8 (IRF-8)(Interferon consensus sequence- IRF8 ENSG00000140968 binding protein)(ICSBP) [Source:UniProtKB/Swiss-Prot;Acc:Q02556] 6.27 8.78 2.50 5.68 8.34E-13 2.90E-10 1.51E-14 1.17E-12 2.74 1 hsa-miR-155, Jouberin (Abelson helper integration site 1 protein homolog)(AHI-1) AHI1 ENSG00000135541 [Source:UniProtKB/Swiss-Prot;Acc:Q8N157] 4.07 6.58 2.51 5.71 1.61E-08 8.62E-07 1.29E-11 4.24E-10 2.62 1 hsa-miR-365, Zinc finger protein 267 (Zinc finger protein 2)(HZF2) ZNF267 ENSG00000185947 [Source:UniProtKB/Swiss-Prot;Acc:Q14586] 5.62 8.14 2.52 5.74 1.21E-06 2.87E-05 6.48E-09 1.02E-07 2.52 1 hsa-miR-424, ADM Precursor [Contains Adrenomedullin(AM);Proadrenomedullin N- 20 terminal peptide(ProAM N-terminal 20 peptide)(ProAM- ADM ENSG00000148926 N20)(PAMP)] [Source:UniProtKB/Swiss-Prot;Acc:P35318] 5.33 7.86 2.53 5.76 1.11E-05 1.71E-04 1.56E-05 1.10E-04 2.53 2 hsa-miR-24,hsa-miR-365, Insulin-like growth factor II Precursor (IGF-II)(Somatomedin-A) [Contains Insulin-like growth factor II Ala-25 Del;Preptin] IGF2 ENSG00000167244 [Source:UniProtKB/Swiss-Prot;Acc:P01344] 5.62 8.15 2.53 5.76 2.24E-10 2.56E-08 3.72E-12 1.43E-10 2.53 2 hsa-miR-18a,hsa-miR-210, Stanniocalcin-2 Precursor (STC-2)(Stanniocalcin-related protein)(STCRP)(STC-related protein) [Source:UniProtKB/Swiss- STC2 ENSG00000113739 Prot;Acc:O76061] 5.29 7.84 2.55 5.87 8.07E-10 7.49E-08 1.72E-13 1.00E-11 2.55 2 hsa-miR-132,hsa-miR-24, Very low-density lipoprotein receptor Precursor (VLDL VLDLR ENSG00000147852 receptor)(VLDL-R) [Source:UniProtKB/Swiss-Prot;Acc:P98155] 4.37 6.92 2.55 5.87 4.03E-12 1.07E-09 6.39E-17 9.99E-15 2.55 2 hsa-miR-200b,hsa-miR-20a, Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10)(TRIP-10)(Protein Felic)(Salt tolerant protein)(hSTP) TRIP10 ENSG00000125733 [Source:UniProtKB/Swiss-Prot;Acc:Q15642] 5.04 7.60 2.56 5.89 8.97E-13 3.04E-10 2.06E-18 5.58E-16 2.65 1 hsa-miR-20a, Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3)(Long-chain acyl- CoA synthetase 4)(LACS 4) [Source:UniProtKB/Swiss- ACSL4 ENSG00000068366 Prot;Acc:O60488] 4.45 7.02 2.57 5.93 2.34E-08 1.17E-06 3.48E-13 1.80E-11 2.68 3 hsa-miR-132,hsa-miR-19a,hsa-miR-7, RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa)(BLAP75)(FAAP75) [Source:UniProtKB/Swiss- RMI1 ENSG00000178966 Prot;Acc:Q9H9A7] 4.32 6.89 2.57 5.94 2.14E-09 1.64E-07 6.67E-15 5.82E-13 3.06 2 hsa-miR-200b,hsa-miR-7, Cytoskeleton-associated protein 2-like [Source:UniProtKB/Swiss- CKAP2L ENSG00000169607 Prot;Acc:Q8IYA6] 4.24 6.82 2.57 5.94 1.08E-10 1.46E-08 1.04E-14 8.49E-13 2.57 1 hsa-miR-18a, DNA polymerase alpha catalytic subunit (EC 2.7.7.7) POLA1 ENSG00000101868 [Source:UniProtKB/Swiss-Prot;Acc:P09884] 4.56 7.14 2.58 6.00 8.58E-09 5.12E-07 2.82E-15 2.74E-13 3.09 2 hsa-miR-206,hsa-miR-218, Nucleoporin Nup43 (p42) [Source:UniProtKB/Swiss- NUP43 ENSG00000120253 Prot;Acc:Q8NFH3] 4.74 7.33 2.59 6.03 3.39E-08 1.57E-06 1.13E-13 6.87E-12 3.17 1 hsa-miR-155, Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss- TUBB ENSG00000196230 Prot;Acc:P07437] 8.17 10.77 2.60 6.06 4.97E-10 5.00E-08 3.85E-17 6.70E-15 2.97 1 hsa-miR-200b, Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein)(Apoptosis-associated nuclear protein)(Proline- and histidine-rich protein)(Proline- and glutamine- PHLDA1 ENSG00000139289 rich protein)(PQ-rich protein) [Source:UniProtKB/Swiss-Prot;Acc:Q 5.73 8.34 2.61 6.11 3.02E-13 1.28E-10 1.77E-19 7.56E-17 2.61 3 hsa-miR-132,hsa-miR-135b,hsa-miR-19a, Cell division cycle-associated protein 7 (Protein JPO1) CDCA7 ENSG00000144354 [Source:UniProtKB/Swiss-Prot;Acc:Q9BWT1] 4.87 7.48 2.61 6.11 4.19E-10 4.39E-08 2.43E-15 2.39E-13 3.03 1 hsa-miR-155, GMNN ENSG00000112312 Geminin [Source:UniProtKB/Swiss-Prot;Acc:O75496] 4.54 7.16 2.62 6.14 1.01E-09 8.84E-08 1.60E-15 1.66E-13 3.32 3 hsa-miR-132,hsa-miR-155,hsa-miR-222, Uncharacterized protein C1orf103 (Receptor-interacting factor 1) C1orf103 ENSG00000121931 [Source:UniProtKB/Swiss-Prot;Acc:Q5T3J3] 4.22 6.85 2.62 6.16 3.71E-06 7.14E-05 2.11E-08 2.93E-07 2.62 1 hsa-miR-155, Protein MCM10 homolog (HsMCM10) [Source:UniProtKB/Swiss- MCM10 ENSG00000065328 Prot;Acc:Q7L590] 4.41 7.07 2.66 6.31 4.08E-11 6.86E-09 3.90E-20 2.15E-17 3.58 1 hsa-miR-7, Myelin protein zero-like protein 2 Precursor (Epithelial V-like antigen MPZL2 ENSG00000149573 1) [Source:UniProtKB/Swiss-Prot;Acc:O60487] 4.67 7.33 2.66 6.32 5.06E-12 1.26E-09 1.04E-13 6.36E-12 2.79 1 hsa-miR-132, PHD finger protein 6 (PHD-like zinc finger protein) PHF6 ENSG00000156531 [Source:UniProtKB/Swiss-Prot;Acc:Q8IWS0] 5.16 7.83 2.67 6.36 1.51E-07 5.29E-06 3.95E-11 1.14E-09 3.15 3 hsa-miR-155,hsa-miR-218,hsa-miR-7, Microtubule-associated serine/threonine-protein kinase-like (EC MASTL ENSG00000120539 2.7.11.1) [Source:UniProtKB/Swiss-Prot;Acc:Q96GX5] 5.18 7.86 2.67 6.38 3.71E-08 1.68E-06 8.86E-12 3.05E-10 2.67 1 hsa-miR-20a, DNA replication complex GINS protein PSF1 (GINS complex subunit GINS1 ENSG00000101003 1) [Source:UniProtKB/Swiss-Prot;Acc:Q14691] 4.42 7.10 2.68 6.40 2.40E-10 2.71E-08 2.58E-19 1.05E-16 3.54 2 hsa-miR-18a,hsa-miR-7, Fructose-bisphosphate aldolase C (EC 4.1.2.13)(Brain-type aldolase) ALDOC ENSG00000109107 [Source:UniProtKB/Swiss-Prot;Acc:P09972] 6.68 9.36 2.68 6.41 1.79E-07 6.07E-06 2.01E-08 2.80E-07 2.68 1 hsa-miR-7, Leukemia inhibitory factor Precursor (LIF)(Differentiation-stimulating factor)(D factor)(Melanoma-derived LPL LIF ENSG00000128342 inhibitor)(MLPLI)(Emfilermin) [Source:UniProtKB/Swiss- 4.76 7.44 2.68 6.41 1.69E-10 2.06E-08 1.97E-19 8.27E-17 3.73 3 hsa-miR-18a,hsa-miR-19a,hsa-miR-20a, Gamma-enolase (EC 4.2.1.11)(2-phospho-D-glycerate hydro- lyase)(Neural enolase)(Neuron-specific enolase)(NSE)(Enolase 2) ENO2 ENSG00000111674 [Source:UniProtKB/Swiss-Prot;Acc:P09104] 7.33 10.02 2.69 6.44 1.17E-07 4.29E-06 6.70E-10 1.38E-08 2.69 1 hsa-miR-24, Wee1-like protein kinase (EC 2.7.10.2)(Wee1A kinase)(WEE1hu) WEE1 ENSG00000166483 [Source:UniProtKB/Swiss-Prot;Acc:P30291] 4.89 7.58 2.69 6.45 2.58E-10 2.91E-08 2.74E-16 3.54E-14 2.85 3 hsa-miR-155,hsa-miR-19b,hsa-miR-222, Uracil phosphoribosyltransferase (EC 2.4.2.9)(UMP pyrophosphorylase)(UPRTase) [Source:UniProtKB/Swiss- UPRT ENSG00000094841 Prot;Acc:Q96BW1] 4.71 7.40 2.69 6.46 3.11E-07 9.45E-06 1.75E-08 2.48E-07 2.69 2 hsa-miR-132,hsa-miR-155, Interleukin-1 alpha Precursor (IL-1 alpha)(Hematopoietin-1) IL1A ENSG00000115008 [Source:UniProtKB/Swiss-Prot;Acc:P01583] 4.29 6.98 2.69 6.46 1.53E-08 8.28E-07 9.18E-13 4.15E-11 3.13 2 hsa-miR-132,hsa-miR-24, Fanconi anemia group J protein (Protein FACJ)(EC 3.6.1.-)(ATP- dependent RNA helicase BRIP1)(BRCA1-interacting protein C- terminal helicase 1)(BRCA1-interacting protein 1)(BRCA1- BRIP1 ENSG00000136492 associated C-terminal helicase 1) [Source:UniProtKB/Swiss- 4.02 6.73 2.71 6.54 5.34E-08 2.27E-06 5.65E-14 3.75E-12 3.33 1 hsa-miR-7, SHC SH2 domain-binding protein 1 [Source:UniProtKB/Swiss- SHCBP1 ENSG00000171241 Prot;Acc:Q8NEM2] 4.53 7.25 2.72 6.60 5.43E-12 1.30E-09 5.69E-19 1.94E-16 2.72 1 hsa-miR-19b, C-4 methylsterol oxidase (EC 1.14.13.72)(Methylsterol SC4MOL ENSG00000052802 monooxygenase) [Source:UniProtKB/Swiss-Prot;Acc:Q15800] 4.89 7.62 2.73 6.63 1.64E-07 5.65E-06 5.84E-13 2.80E-11 3.46 2 hsa-miR-19a,hsa-miR-200b, Protein phosphatase methylesterase 1 (PME-1)(EC 3.1.1.-) PPME1 ENSG00000214517 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y570] 5.53 8.26 2.73 6.64 6.17E-10 6.00E-08 1.55E-12 6.60E-11 2.73 3 hsa-miR-218,hsa-miR-27a,hsa-miR-7, Trifunctional purine biosynthetic protein adenosine-3 [Includes Phosphoribosylamine--glycine ligase(EC 6.3.4.13)(Glycinamide ribonucleotide synthetase)(GARS)(Phosphoribosylglycinamide synthetase);Phosphoribosylformylglycinamidine cyclo-ligase(EC GART ENSG00000159131 6.3.3.1)( 6.10 8.83 2.73 6.65 6.50E-10 6.19E-08 3.47E-17 6.19E-15 3.32 1 hsa-miR-7, Transmembrane protease, serine 3 (EC 3.4.21.-)(Tumor-associated differentially-expressed gene 12 protein)(Serine protease TADG-12) TMPRSS3 ENSG00000160183 [Source:UniProtKB/Swiss-Prot;Acc:P57727] 5.17 7.91 2.74 6.68 5.18E-11 8.16E-09 2.02E-10 4.80E-09 2.74 1 hsa-miR-221, Vascular endothelial growth factor receptor 1 Precursor (VEGFR- 1)(EC 2.7.10.1)(Vascular permeability factor receptor)(Tyrosine- protein kinase receptor FLT)(Flt-1)(Tyrosine-protein kinase FLT1 ENSG00000102755 FRT)(Fms-like tyrosine kinase 1) [Source:UniProtKB/Swiss- 4.45 7.19 2.74 6.69 5.20E-13 1.98E-10 1.66E-17 3.21E-15 2.74 2 hsa-miR-200b,hsa-miR-218, FERM domain-containing protein 4B (GRP1-binding protein GRSP1) FRMD4B ENSG00000114541 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2L6] 5.34 8.08 2.75 6.72 2.05E-10 2.40E-08 5.75E-15 5.17E-13 2.75 2 hsa-miR-218,hsa-miR-7, Arginase-2, mitochondrial Precursor (Arginase II)(EC 3.5.3.1)(Non- hepatic arginase)(Kidney-type arginase) [Source:UniProtKB/Swiss- ARG2 ENSG00000081181 Prot;Acc:P78540] 4.54 7.30 2.75 6.74 3.54E-11 6.07E-09 2.45E-11 7.47E-10 2.75 1 hsa-miR-206, Syndecan-4 Precursor (SYND4)(Amphiglycan)(Ryudocan core SDC4 ENSG00000124145 protein) [Source:UniProtKB/Swiss-Prot;Acc:P31431] 4.77 7.52 2.75 6.75 8.66E-14 4.77E-11 3.13E-22 3.61E-19 2.92 1 hsa-miR-18a, Dual specificity protein phosphatase 4 (EC 3.1.3.48)(EC 3.1.3.16)(Mitogen-activated protein kinase phosphatase 2)(MAP kinase phosphatase 2)(MKP-2)(Dual specificity protein phosphatase DUSP4 ENSG00000120875 hVH2) [Source:UniProtKB/Swiss-Prot;Acc:Q13115] 5.53 8.28 2.76 6.75 7.70E-11 1.13E-08 3.65E-16 4.60E-14 2.76 1 hsa-let-7f, DCN1-like protein 5 (Defective in cullin neddylation protein 1-like protein 5)(DCUN1 domain-containing protein 5) DCUN1D5 ENSG00000137692 [Source:UniProtKB/Swiss-Prot;Acc:Q9BTE7] 5.42 8.18 2.76 6.77 1.99E-09 1.53E-07 4.57E-15 4.25E-13 3.20 1 hsa-miR-365, Charged multivesicular body protein 5 (Chromatin-modifying protein 5)(Vacuolar protein-sorting-associated protein 60)(Vps60)(hVps60)(SNF7 domain-containing protein 2) CHMP5 ENSG00000086065 [Source:UniProtKB/Swiss-Prot;Acc:Q9NZZ3] 5.83 8.61 2.79 6.90 1.01E-06 2.46E-05 8.61E-11 2.25E-09 2.79 1 hsa-miR-200b, Transmembrane protein 45A (DNA polymerase-transactivated protein 4)(Dermal papilla-derived protein 7) [Source:UniProtKB/Swiss- TMEM45A ENSG00000181458 Prot;Acc:Q9NWC5] 4.19 6.98 2.79 6.92 6.51E-08 2.68E-06 9.13E-10 1.79E-08 2.79 1 hsa-miR-19a, Protein regulator of cytokinesis 1 [Source:UniProtKB/Swiss- PRC1 ENSG00000198901 Prot;Acc:O43663] 4.43 7.23 2.80 6.94 6.98E-13 2.49E-10 5.55E-18 1.27E-15 2.80 1 hsa-miR-19a, CD109 antigen Precursor (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7)(150 KDa TGF-beta-1-binding protein)(Platelet-specific Gov antigen)(p180)(r150)(CD109 antigen) CD109 ENSG00000156535 [Source:UniProtKB/Swiss-Prot;Acc:Q6YHK3] 4.28 7.08 2.80 6.96 7.36E-12 1.68E-09 8.52E-17 1.29E-14 2.80 2 hsa-miR-155,hsa-miR-7, LMNB1 ENSG00000113368 Lamin-B1 [Source:UniProtKB/Swiss-Prot;Acc:P20700] 5.57 8.38 2.81 7.00 3.67E-11 6.22E-09 3.96E-17 6.78E-15 2.81 2 hsa-miR-218,hsa-miR-7, DNA2-like helicase (EC 3.6.1.-)(DNA replication ATP-dependent DNA2 ENSG00000138346 helicase-like homolog) [Source:UniProtKB/Swiss-Prot;Acc:P51530] 3.76 6.57 2.81 7.01 4.14E-09 2.80E-07 4.01E-16 4.97E-14 3.53 3 hsa-let-7f,hsa-miR-218,hsa-miR-7, Zinc finger protein PLAGL2 (Pleiomorphic adenoma-like protein 2) PLAGL2 ENSG00000126003 [Source:UniProtKB/Swiss-Prot;Acc:Q9UPG8] 5.57 8.39 2.82 7.05 6.18E-10 6.00E-08 1.15E-15 1.25E-13 3.03 3 hsa-miR-18a,hsa-miR-27a,hsa-miR-7, Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta)(eIF-2-beta) EIF2S2 ENSG00000125977 [Source:UniProtKB/Swiss-Prot;Acc:P20042] 6.12 9.05 2.93 7.60 6.79E-09 4.26E-07 1.77E-13 1.02E-11 2.93 2 hsa-miR-27a,hsa-miR-29b, C-C motif chemokine 4-like Precursor (Small-inducible cytokine A4- like)(Lymphocyte activation gene 1 protein)(LAG-1)(Macrophage inflammatory protein 1-beta)(MIP-1-beta)(Monocyte adherence- induced protein 5-alpha) [Source:UniProtKB/Swiss- CCL4L1 ENSG00000205020 Prot;Acc:Q8NHW4] 6.48 9.43 2.95 7.72 6.83E-09 4.27E-07 4.84E-16 5.84E-14 3.27 1 hsa-miR-24, Centromere protein N (CENP-N)(Interphase centromere complex CENPN ENSG00000166451 protein 32) [Source:UniProtKB/Swiss-Prot;Acc:Q96H22] 4.21 7.16 2.95 7.74 2.99E-11 5.31E-09 1.56E-17 3.03E-15 3.24 2 hsa-miR-210,hsa-miR-218, Spindle and kinetochore-associated protein 2 (Protein FAM33A) FAM33A ENSG00000182628 [Source:UniProtKB/Swiss-Prot;Acc:Q8WVK7] 4.22 7.19 2.97 7.81 4.47E-08 1.95E-06 2.75E-12 1.09E-10 3.17 3 hsa-miR-132,hsa-miR-18a,hsa-miR-7, HIST1H4B ENSG00000124529 Histone H4 [Source:UniProtKB/Swiss-Prot;Acc:P62805] 6.51 9.52 3.01 8.06 6.09E-08 2.53E-06 2.09E-10 4.96E-09 3.01 1 hsa-miR-7, Coiled-coil domain-containing protein 58 [Source:UniProtKB/Swiss- CCDC58 ENSG00000160124 Prot;Acc:Q4VC31] 5.75 8.80 3.05 8.30 1.62E-09 1.30E-07 1.40E-16 2.02E-14 3.51 1 hsa-miR-24, WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1)(And-1) WDHD1 ENSG00000198554 [Source:UniProtKB/Swiss-Prot;Acc:O75717] 4.38 7.48 3.10 8.57 1.30E-10 1.68E-08 7.32E-18 1.63E-15 3.53 1 hsa-miR-155, Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 BRCA2 ENSG00000139618 protein) [Source:UniProtKB/Swiss-Prot;Acc:P51587] 3.87 6.97 3.10 8.57 2.35E-11 4.33E-09 1.22E-15 1.32E-13 3.10 1 hsa-miR-200b, Cytotoxic T-lymphocyte protein 4 Precursor (Cytotoxic T-lymphocyte- associated antigen 4)(CTLA-4)(CD152 antigen) CTLA4 ENSG00000163599 [Source:UniProtKB/Swiss-Prot;Acc:P16410] 6.80 9.91 3.12 8.67 9.14E-10 8.24E-08 3.95E-17 6.78E-15 3.12 2 hsa-miR-155,hsa-miR-18a, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (Beta-1,3-N-acetylglucosaminyltransferase-5)(Beta3Gn-T5)(BGnT- 5)(EC 2.4.1.-)(Lactotriaosylceramide synthase)(Lc(3)Cer synthase)(Lc3 synthase) [Source:UniProtKB/Swiss- B3GNT5 ENSG00000176597 Prot;Acc:Q9BYG0] 4.41 7.53 3.12 8.69 1.80E-11 3.51E-09 3.70E-13 1.90E-11 3.12 1 hsa-miR-221, Actin-binding protein anillin [Source:UniProtKB/Swiss- ANLN ENSG00000011426 Prot;Acc:Q9NQW6] 3.73 6.86 3.13 8.73 9.94E-12 2.16E-09 3.60E-17 6.35E-15 3.13 1 hsa-miR-200b, Transmembrane protein 194A [Source:UniProtKB/Swiss- TMEM194A ENSG00000166881 Prot;Acc:O14524] 5.20 8.33 3.13 8.76 6.49E-10 6.19E-08 1.85E-15 1.87E-13 3.13 2 hsa-miR-155,hsa-miR-24, NRN1 ENSG00000124785 Neuritin Precursor [Source:UniProtKB/Swiss-Prot;Acc:Q9NPD7] 4.19 7.34 3.15 8.90 7.60E-08 3.02E-06 4.08E-08 5.30E-07 3.15 2 hsa-miR-218,hsa-miR-7, Coagulation factor V Precursor (Activated protein C cofactor)(Proaccelerin, labile factor) [Contains Coagulation factor V heavy chain;Coagulation factor V light chain] F5 ENSG00000198734 [Source:UniProtKB/Swiss-Prot;Acc:P12259] 4.31 7.47 3.16 8.95 3.28E-12 8.97E-10 2.69E-16 3.49E-14 3.30 2 hsa-miR-155,hsa-miR-7, C-C motif chemokine 4 Precursor (Small-inducible cytokine A4)(Macrophage inflammatory protein 1-beta)(MIP-1-beta)(MIP-1- beta(1-69))(T-cell activation protein 2)(ACT-2)(PAT 744)(Protein H400)(SIS-gamma)(Lymphocyte activation gene 1 protein)(LAG- CCL4 ENSG00000129277 1)(HC21)(G- 6.47 9.63 3.17 8.98 4.50E-10 4.62E-08 3.42E-18 8.28E-16 3.79 1 hsa-miR-24, RAD51-associated protein 1 (RAD51-interacting protein) RAD51AP1 ENSG00000111247 [Source:UniProtKB/Swiss-Prot;Acc:Q96B01] 3.80 7.02 3.21 9.29 4.10E-11 6.86E-09 9.03E-18 1.95E-15 3.58 2 hsa-miR-18a,hsa-miR-21, Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c))(EC 2.6.1.42)(Protein ECA39) [Source:UniProtKB/Swiss- BCAT1 ENSG00000060982 Prot;Acc:P54687] 4.50 7.74 3.24 9.47 2.21E-14 1.80E-11 2.15E-22 2.67E-19 3.24 3 hsa-miR-135b,hsa-miR-155,hsa-miR-218, Rho GTPase-activating protein 11A (Rho-type GTPase-activating ARHGAP11A ENSG00000198826 protein 11A) [Source:UniProtKB/Swiss-Prot;Acc:Q6P4F7] 4.37 7.63 3.26 9.55 1.67E-12 5.33E-10 3.53E-18 8.49E-16 3.26 2 hsa-miR-155,hsa-miR-19a, Meiotic recombination protein DMC1/LIM15 homolog DMC1 ENSG00000100206 [Source:UniProtKB/Swiss-Prot;Acc:Q14565] 3.92 7.19 3.27 9.65 4.82E-13 1.89E-10 3.20E-17 5.76E-15 3.27 1 hsa-miR-24, Alanyl-tRNA synthetase, cytoplasmic (EC 6.1.1.7)(Alanine--tRNA ligase)(AlaRS)(Renal carcinoma antigen NY-REN-42) AARS ENSG00000090861 [Source:UniProtKB/Swiss-Prot;Acc:P49588] 5.99 9.27 3.28 9.71 6.29E-11 9.55E-09 1.75E-19 7.54E-17 3.28 1 hsa-miR-24, DEP domain-containing protein 1B (HBV X-transactivated gene 8 DEPDC1B ENSG00000035499 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q8WUY9] 4.50 7.79 3.29 9.76 5.28E-15 5.40E-12 3.75E-18 8.95E-16 3.29 1 hsa-miR-27a, DNA replication licensing factor MCM6 (p105MCM) MCM6 ENSG00000076003 [Source:UniProtKB/Swiss-Prot;Acc:Q14566] 5.57 8.87 3.30 9.88 3.60E-11 6.13E-09 7.59E-18 1.67E-15 3.72 1 hsa-miR-7, CETN3 ENSG00000153140 Centrin-3 [Source:UniProtKB/Swiss-Prot;Acc:O15182] 3.84 7.15 3.31 9.93 1.87E-09 1.46E-07 1.26E-15 1.35E-13 3.79 1 hsa-miR-132, Retinoblastoma-binding protein 8 (RBBP-8)(CtBP-interacting protein)(CtIP)(Retinoblastoma-interacting protein and myosin- RBBP8 ENSG00000101773 like)(RIM) [Source:UniProtKB/Swiss-Prot;Acc:Q99708] 3.54 6.92 3.38 10.40 1.84E-11 3.57E-09 2.90E-18 7.41E-16 3.93 3 hsa-miR-130b,hsa-miR-18a,hsa-miR-19a, FAM40B ENSG00000128578 Protein FAM40B [Source:UniProtKB/Swiss-Prot;Acc:Q9ULQ0] 4.43 7.81 3.38 10.41 2.25E-13 1.05E-10 5.45E-21 4.24E-18 3.41 1 hsa-miR-7, Solute carrier family 43 member 3 (Protein FOAP-13) SLC43A3 ENSG00000134802 [Source:UniProtKB/Swiss-Prot;Acc:Q8NBI5] 5.82 9.22 3.40 10.55 6.25E-17 3.91E-13 2.23E-26 1.14E-22 3.64 1 hsa-miR-7, Lymphoid-specific helicase (EC 3.6.1.-)(SWI/SNF2-related matrix- associated actin-dependent regulator of chromatin subfamily A member 6)(Proliferation-associated SNF2-like protein) HELLS ENSG00000119969 [Source:UniProtKB/Swiss-Prot;Acc:Q9NRZ9] 3.77 7.19 3.42 10.71 7.97E-11 1.16E-08 9.96E-18 2.08E-15 4.03 2 hsa-miR-24,hsa-miR-7, Centrosomal protein of 55 kDa (Cep55)(Up-regulated in colon cancer CEP55 ENSG00000138180 6) [Source:UniProtKB/Swiss-Prot;Acc:Q53EZ4] 4.21 7.67 3.46 10.99 1.23E-15 2.10E-12 4.04E-20 2.19E-17 3.46 1 hsa-miR-19a, Kinesin-like protein KIF23 (Mitotic kinesin-like protein 1)(Kinesin-like KIF23 ENSG00000137807 protein 5) [Source:UniProtKB/Swiss-Prot;Acc:Q02241] 3.97 7.44 3.47 11.05 3.05E-13 1.28E-10 1.52E-18 4.31E-16 3.47 1 hsa-miR-424, Interferon gamma Precursor (IFN-gamma)(Immune interferon) IFNG ENSG00000111537 [Source:UniProtKB/Swiss-Prot;Acc:P01579] 5.33 8.80 3.47 11.09 1.64E-07 5.65E-06 5.55E-15 5.06E-13 4.96 1 hsa-miR-24, Myosin-Ib (Myosin I alpha)(MMI-alpha)(MMIa)(MYH-1c) MYO1B ENSG00000128641 [Source:UniProtKB/Swiss-Prot;Acc:O43795] 3.78 7.34 3.56 11.81 4.27E-10 4.45E-08 4.85E-13 2.41E-11 3.56 1 hsa-miR-155, Chloride intracellular channel protein 4 (Intracellular chloride ion CLIC4 ENSG00000169504 channel protein p64H1) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y696] 4.36 7.99 3.63 12.38 1.20E-11 2.52E-09 9.74E-18 2.05E-15 3.63 3 hsa-miR-155,hsa-miR-200b,hsa-miR-7, Structural maintenance of chromosomes protein 2 (Chromosome- associated protein E)(hCAP-E)(XCAP-E homolog) SMC2 ENSG00000136824 [Source:UniProtKB/Swiss-Prot;Acc:O95347] 4.05 7.72 3.67 12.70 1.20E-10 1.57E-08 8.50E-17 1.29E-14 3.67 1 hsa-miR-7, DEP domain-containing protein 1A [Source:UniProtKB/Swiss- DEPDC1 ENSG00000024526 Prot;Acc:Q5TB30] 3.21 6.90 3.69 12.87 1.72E-13 8.19E-11 1.51E-17 2.97E-15 3.69 2 hsa-miR-21,hsa-miR-7, 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18)(Glycogen- branching enzyme)(Brancher enzyme) [Source:UniProtKB/Swiss- GBE1 ENSG00000114480 Prot;Acc:Q04446] 5.40 9.11 3.72 13.15 3.12E-11 5.40E-09 6.80E-13 3.19E-11 3.72 1 hsa-miR-222, Prolyl 4-hydroxylase subunit alpha-1 Precursor (EC 1.14.11.2)(4-PH alpha-1)(Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit P4HA1 ENSG00000122884 alpha-1) [Source:UniProtKB/Swiss-Prot;Acc:P13674] 4.94 8.72 3.78 13.74 2.61E-08 1.28E-06 1.49E-10 3.65E-09 3.78 1 hsa-miR-21, Fanconi anemia group I protein (Protein FANCI) FANCI ENSG00000140525 [Source:UniProtKB/Swiss-Prot;Acc:Q9NVI1] 4.34 8.28 3.94 15.33 1.17E-11 2.49E-09 8.91E-19 2.82E-16 4.18 1 hsa-miR-218, PCNA-associated factor (p15PAF)(Overexpressed in anaplastic thyroid carcinoma 1)(OEATC-1)(Hepatitis C virus NS5A- transactivated protein 9)(HCV NS5A-transactivated protein 9) KIAA0101 ENSG00000166803 [Source:UniProtKB/Swiss-Prot;Acc:Q15004] 4.69 8.64 3.95 15.48 4.58E-16 1.13E-12 4.83E-26 2.16E-22 4.30 2 hsa-miR-19a,hsa-miR-200b, Cyclin-dependent kinases regulatory subunit 2 (CKS-2) CKS2 ENSG00000123975 [Source:UniProtKB/Swiss-Prot;Acc:P33552] 4.80 8.78 3.99 15.85 9.56E-12 2.13E-09 4.29E-16 5.26E-14 3.99 1 hsa-miR-7, Cell division control protein 6 homolog (CDC6-related protein)(p62(cdc6))(HsCDC6)(HsCDC18) [Source:UniProtKB/Swiss- CDC6 ENSG00000094804 Prot;Acc:Q99741] 3.65 7.68 4.04 16.41 2.09E-13 9.83E-11 2.83E-22 3.38E-19 4.89 2 hsa-miR-155,hsa-miR-365, Glycerol kinase (EC 2.7.1.30)(ATP:glycerol 3- phosphotransferase)(Glycerokinase)(GK) [Source:UniProtKB/Swiss- GK ENSG00000198814 Prot;Acc:P32189] 4.78 8.85 4.07 16.77 5.32E-14 3.27E-11 4.88E-21 4.06E-18 4.07 1 hsa-miR-7, Dihydrofolate reductase (EC 1.5.1.3) [Source:UniProtKB/Swiss- DHFR ENSG00000228716 Prot;Acc:P00374] 4.40 8.49 4.09 16.99 3.86E-10 4.14E-08 7.24E-16 8.28E-14 4.58 1 hsa-miR-18a, Interferon regulatory factor 4 (IRF-4)(Lymphocyte-specific interferon regulatory factor)(LSIRF)(NF-EM5)(Multiple myeloma oncogene 1) IRF4 ENSG00000137265 [Source:UniProtKB/Swiss-Prot;Acc:Q15306] 6.03 10.11 4.09 17.00 6.54E-17 3.91E-13 1.89E-28 3.38E-24 4.09 2 hsa-miR-27a,hsa-miR-7, Multifunctional protein ADE2 [Includes Phosphoribosylaminoimidazole- succinocarboxamide synthase(EC 6.3.2.6)(SAICAR synthetase);Phosphoribosylaminoimidazole carboxylase(EC 4.1.1.21)(AIR carboxylase)(AIRC)] [Source:UniProtKB/Swiss- PAICS ENSG00000128050 Prot;Acc:P22234] 5.72 9.85 4.13 17.49 5.07E-11 8.10E-09 1.58E-18 4.43E-16 4.52 1 hsa-miR-7, Centromere protein U (CENP-U(50))(CENP-U)(CENP- 50)(Interphase centromere complex protein 24)(MLF1-interacting protein)(KSHV latent nuclear antigen-interacting protein 1)(Polo-box- MLF1IP ENSG00000151725 interacting protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q71F23] 3.22 7.37 4.14 17.66 6.48E-12 1.50E-09 7.15E-17 1.10E-14 4.52 1 hsa-miR-18a, Phosphoserine aminotransferase (EC 2.6.1.52)(Phosphohydroxythreonine aminotransferase)(PSAT) PSAT1 ENSG00000135069 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y617] 4.91 9.12 4.21 18.46 3.85E-16 1.06E-12 2.92E-28 3.49E-24 4.53 1 hsa-miR-18a, Acyl-CoA desaturase (EC 1.14.19.1)(Stearoyl-CoA desaturase)(Fatty acid desaturase)(Delta(9)-desaturase) [Source:UniProtKB/Swiss- SCD ENSG00000099194 Prot;Acc:O00767] 5.02 9.29 4.26 19.22 5.89E-16 1.19E-12 5.47E-23 9.33E-20 4.49 4 hsa-miR-19a,hsa-miR-200b,hsa-miR-221,hsa-miR-98, Dual specificity protein kinase TTK (EC 2.7.12.1)(Phosphotyrosine picked threonine-protein kinase)(PYT) [Source:UniProtKB/Swiss- TTK ENSG00000112742 Prot;Acc:P33981] 2.99 7.28 4.29 19.58 7.02E-13 2.49E-10 1.27E-18 3.73E-16 4.29 1 hsa-miR-132, Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) CHEK1 ENSG00000149554 [Source:UniProtKB/Swiss-Prot;Acc:O14757] 4.19 8.52 4.33 20.11 2.69E-14 2.10E-11 1.75E-23 3.68E-20 4.39 1 hsa-miR-7, Maternal embryonic leucine zipper kinase (hMELK)(EC 2.7.11.1)(Protein kinase PK38)(hPK38) [Source:UniProtKB/Swiss- MELK ENSG00000165304 Prot;Acc:Q14680] 3.22 7.69 4.46 22.03 7.18E-16 1.35E-12 2.78E-23 5.53E-20 4.46 1 hsa-miR-7, Interleukin-2 receptor alpha chain Precursor (IL-2 receptor alpha subunit)(IL-2-RA)(IL2-RA)(p55)(TAC antigen)(CD25 antigen) IL2RA ENSG00000134460 [Source:UniProtKB/Swiss-Prot;Acc:P01589] 5.46 9.92 4.46 22.04 1.08E-16 4.84E-13 1.09E-28 3.38E-24 4.46 1 hsa-miR-21, NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A)(Putative MAPK-activating protein PM04/PM05/PM06/PM07)(Putative NF-kappa-B-activating protein NDFIP2 ENSG00000102471 413) [Source:UniProtKB/Swiss-Prot;Acc:Q9NV92] 4.00 8.69 4.69 25.82 3.85E-16 1.06E-12 1.15E-25 4.11E-22 4.69 1 hsa-miR-221, DNA topoisomerase 2-alpha (EC 5.99.1.3)(DNA topoisomerase II, TOP2A ENSG00000131747 alpha isozyme) [Source:UniProtKB/Swiss-Prot;Acc:P11388] 3.13 8.68 5.54 46.59 4.59E-15 4.98E-12 7.72E-22 7.90E-19 5.54 1 hsa-miR-21, Supplemental Table S3: Functional molecular networks populated by downregulated gene targets of upregulated miRNAs 0 vs. 48 hours Focus Network Molecules in Network Score Molecules Top Functions Actin, Akt, Alpha tubulin, ARHGEF11, ARHGEF18, ATM, BTG1, BTG2, Cell Cycle, Caspase, Cytochrome c, DYRK2, ENC1, EPHA4, FOSB, hCG, HIP1R, Ikk Neurological (family), Insulin, IRS2, MAFB, MAP2K1/2, MOAP1, NCAM1, NGF, p85 Disease, Skeletal (pik3r), PARK2, Pdgf, PIK3R1, PP2A, PPP2R2B, Ras homolog, RNF139, and Muscular 1 SLC4A4, TULP4, WISP1 36 21 Disorders CLCF1, CLEC7A, Collagen type I, Collagen type III, Collagen type IV, Cellular Collagen(s), CR1, EDAR, Fc gamma receptor, Fc receptor, Fcgr2, Development, FCGR1A/2A/3A, FCGR2A, FCGR2B, FCGR3A, FCGRT, FGR, IgG, IgG1, Inflammatory IgG2a, IL1, ITPKB, KLF3, LAIR1, NCK, NFkB (complex), RALGPS1, Response, Cellular SPARC, SWI-SNF, TGFBI, TIMP2, TNFAIP3, TOB1, TXNIP, ZBP1 Function and 2 34 20 Maintenance ACSL6, ADAMTS10 (includes EG:81794), AMT (includes EG:275), C7ORF43, CACNA2D2, CD84, DIRC2, EPO, FAM125B, FOS, HNF4A, IDS, LCK, LPCAT3, MIR325 (includes EG:100313970), MIR93 (includes Lipid Metabolism, EG:407050), oleic acid, PLEKHM1, RBM6, RNF44, RPLP0 (includes Molecular EG:11837), SAMHD1, SIDT1, STAT3, STMN3, TMEM63A, TOR2A, Transport, Small TP53INP2, TSG101, TSPAN14, VPS37B, WBSCR22, YPEL5, ZNF133, Molecule 3 ZNF467 32 20 Biochemistry AHNAK, BTK, CBP-ICSBP-IRF-1-PU.1, CCNL1, CSF1R, CYBB, DUSP1, Cellular ERK1/2, GAS7, GC-GCR dimer, Glucocorticoid-GCR, IFN TYPE 1, Ige, Development, IL12 (complex), IL12A, Immunoglobulin, IRF1, ITGA6, ITM2B, JAK, KIT, Hematological KLRG1, Laminin, LDL, LEPROTL1, LYPD3, MAP2K6, Mek, MHC Class II System (complex), PDGF BB, PLC gamma, SPI1, STAT5a/b, TCF7, TSC22D3 Development and Function, 4 31 19 Hematopoiesis Alp, AUTS2 (includes EG:26053), COL6A2, collagen, CRY2, CTSK, Cyclin E, DUSP8, Fgf, GPA33, Hsp27, Hsp70, IFN Beta, Ifn gamma, IL6R, Gene Expression, Interferon alpha, IRF, KLF4, MEF2C, Mmp, P38 MAPK, PARP, PER1, Cell Morphology, phosphoinositide phospholipase C, PI3K (complex), PIK3IP1, PLCD1, Cellular Assembly 5 PLCL1, PLCL2, Sapk, Tgf beta, TIPARP, TLR4, Tnf, TRIB2 27 17 and Organization 26s Proteasome, Ap1, ARL4C, ASC2, Calpain, Ck2, Creb, Cyclin A, DISC1, Connective Tissue F Actin, FSH, Histone h3, Hsp90, Ifn, IKBKE, JUN, Lh, MAFK, NR3C2, Disorders, NR4A2, NRCAM, PDE4B, PDLIM3, Pro-inflammatory Cytokine, PTCH1, Developmental RNA polymerase II, ROGDI, SCARB2, TCR, Ubiquitin, Vegf, WNT7A, Disorder, ZFP36, ZFP36L2, ZNF238 Dermatological Diseases and 6 25 16 Conditions ANKRD13D, beta-estradiol, CACNA1G, Cacna1g/h/i, CACNA1I, CACNB1, Cardiovascular CACNB2, CHGA, CNPY2, COMT, CTSB, DIO2, ERP27, GAL, HCRT, System LRRC8A, MIR1, MIR26B (includes EG:407017), MPEG1, MXD4, MYL12B, Development and MYLIP, NAP1L5, norepinephrine, OSBPL5, OSBPL7, OXT, PBXIP1, Function, Nervous PELI2, PLXDC1, PTPRN, SCML4, TRIB2, UBQLN4, UCN2 System Development and 7 23 15 Function, Behavior AGTR1B, ANKS1A, ARF6, CECR1, ceramide, CFLAR, COL1A1, CTSL2, Cell Death, Liver EGFR, GCLM, heparan sulfate, HSP90AA1, IFNG, KCNA3, LAMP2, Necrosis/Cell LDHA, LLGL2, MAP7D1, MEGF6, MIR183 (includes EG:406959), MMP8, Death, Cell- MYC, NAV1, NIPSNAP1, NLRC5 (includes EG:84166), NMI, PLXND1, mediated Immune 8 SEMA4F, SLC14A1, SLC40A1, SUN2, TACR1, TLE4, TRAM2, XYLT1 23 15 Response ABCA2, ALS2CL, CCR4, COLQ, Cyclooxygenase, DCHS1, EHD1, ESR1, Antigen EWSR1, FAM102A, FAM46C (includes EG:54855), HSD3B2, IL4, LTBP1, Presentation, MCM5, MMP10, MYO1F, PKIB, POU4F2, PSMC5, RAB37, RAB5A, Cellular RPS6KA3, SNN, SNRK, SVIL, TACR1, TCF7, TDG, TNF, TP73, TREM1, Development, TRIP6, TSPYL1, VASH1 Hematological System 9 21 14 Development and Function

APBA2, APP, AXIN2, C2ORF18, CREB1, CSGALNACT1, EFHC2, Cellular EIF4EBP2, ELK4, FAM65B, FRAT2, GHRHR, KLF5, LDLRAP1, MAPK3, Movement, MIDN, MMP10, MMP1 (includes EG:4312), NAE1, NCOR1, NECAB3, Nervous System Neurotrophin, NR1D2, PDGFD, PRNP, retinoic acid, RLN2, RPS6KA4, Development and SCML1 (includes EG:6322), SERPINE2, TGFB3, TGFBI, TPR, TSPAN2, Function, Cell 10 ZBTB7A 20 14 Death ADCY, ADRB2, C1R, CCR9, CHEMOKINE, CX3CR1, ERK, Focal adhesion kinase, FOS, FPR1, G protein, G protein alphai, GABBR1, Gi- Cell Signaling, coupled receptor, GNRH, Gpcr, Gs-coupled receptor, IKK (complex), IL12 Molecular (family), Jnk, Mapk, P2RY13, Pias, Pka, Pkc(s), PLC, PTGDR, PTGER4, Transport, Nucleic 11 Ras, RGS1, S1PR5, STAT, Trypsin, VIPR1, ZNF652 20 14 Acid Metabolism ACVR2B, AGPAT4, AKT3, AMIGO1, BCL9L, CSH1, CSTA, CTNNB1, Cardiovascular DUSP1, INS1, KRT8, L3MBTL3, LAMA5, MAN2B2 (includes EG:23324), System MAP3K1, MEGF9, MIR328 (includes EG:100314218), MIR346 (includes Development and EG:100314221), MST1R, PCSK1, PDP1, PHF15, PTHLH, RBL1, RNF166, Function, Digestive RPS6, RPS6KA3, SMAD2, TNC, TRH, TRIM62, UBE2D2, USP9X, System ZFYVE9, ZNF385A Development and Function, Organ 12 16 12 Development

Delta log2_fold- fold- rawp- adjp- Average Average Spectral Average T0 Average T48 T48_vs_T0 T48_vs_T0 T48_vs_T0 T48_vs_T0 Spectral Spectral T48/T0 counts T48- Targeted by miRNA(includes only miRs Symbol Ensembl_gene Definition log2 mRNA log2 mRNA mRNA mRNA mRNA mRNA counts T0 counts T48 Protein T0 #Mirs upregulated as determined by t-test)

Structural maintenance of chromosomes protein 1A (SMC1alpha hsa-miR-132,hsa-miR-135b,hsa-miR- SMC1A ENSG00000072501 protein)(Sb1.8) [Source:UniProtKB/Swiss-Prot;Acc:Q14683] 5.80 7.38 1.58 2.98 8.05E-06 1.33E-04 9.25E-05 0.00E+00 -9.25E-05 6 18a,hsa-miR-21,hsa-miR-218,hsa-miR-7, Plastin-1 (Intestine-specific plastin)(I-plastin) [Source:UniProtKB/Sw iss- hsa-miR-132,hsa-miR-155,hsa-miR- PLS1 ENSG00000120756 Prot;Acc:Q14651] 5.43 6.26 0.83 1.78 7.03E-05 7.72E-04 2.94E-04 0.00E+00 -2.94E-04 5 19a,hsa-miR-27a,hsa-miR-7, Fragile X mental retardation syndrome-related protein 1 (hFXR1p) hsa-miR-132,hsa-miR-155,hsa-miR- FXR1 ENSG00000114416 [Source:UniProtKB/Swiss-Prot;Acc:P51114] 6.60 7.80 1.20 2.29 8.16E-04 5.78E-03 1.46E-04 0.00E+00 -1.46E-04 5 19a,hsa-miR-200b,hsa-miR-7, Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in hsa-miR-132,hsa-miR-155,hsa-miR- PEA15 ENSG00000162734 diabetes)(PED) [Source:UniProtKB/Swiss-Prot;Acc:Q15121] 6.43 7.56 1.13 2.18 1.71E-07 5.83E-06 0.00E+00 7.57E-05 7.57E-05 5 19a,hsa-miR-24,hsa-miR-7, Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase)(EC 2.3.3.10)(3-hydroxy-3-methylglutaryl coenzyme A hsa-miR-155,hsa-miR-18a,hsa-miR- HMGCS1 ENSG00000112972 synthase) [Source:UniProtKB/Swiss-Prot;Acc:Q01581] 5.72 7.58 1.86 3.63 4.36E-07 1.24E-05 0.00E+00 1.10E-04 1.10E-04 5 19a,hsa-miR-27a,hsa-miR-365, N-acetyltransferase 13 (EC 2.3.1.-)(N-acetyltransferase 5)(hNAT5)(N- acetyltransferase san homolog)(hSAN) [Source:UniProtKB/Swiss- hsa-miR-130b,hsa-miR-155,hsa-miR- NAT13 ENSG00000121579 Prot;Acc:Q9GZZ1] 7.31 8.21 0.91 1.88 1.25E-04 1.23E-03 0.00E+00 1.61E-04 1.61E-04 5 18a,hsa-miR-27a,hsa-miR-365, hsa-miR-218,hsa-miR-221,hsa-miR- CRKL ENSG00000099942 Crk-like protein [Source:UniProtKB/Swiss-Prot;Acc:P46109] 7.29 8.32 1.03 2.04 7.95E-06 1.31E-04 0.0004922 0.0002388 0.49 -2.53E-04 4 365,hsa-miR-7, Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85 subunit alpha)(PtdIns-3-kinase p85-alpha)(PI3K) hsa-miR-155,hsa-miR-21,hsa-miR-218,hsa- PIK3R1 ENSG00000145675 [Source:UniProtKB/Swiss-Prot;Acc:P27986] 7.94 6.37 -1.57 -2.98 2.41E-04 2.12E-03 0.00028645 0.00011147 0.39 -1.75E-04 4 miR-221, Integrin alpha-2 Precursor (Platelet membrane glycoprotein Ia)(GPIa)(Collagen receptor)(VLA-2 alpha chain)(CD49 antigen-like family member B)(CD49b antigen) [Source:UniProtKB/Swiss- hsa-miR-19a,hsa-miR-200b,hsa-miR- ITGA2 ENSG00000164171 Prot;Acc:P17301] 5.23 6.50 1.27 2.41 5.20E-06 9.33E-05 1.48E-04 0.00E+00 -1.48E-04 4 24,hsa-miR-27a, hsa-miR-155,hsa-miR-200b,hsa-miR- BCL2 ENSG00000171791 Apoptosis regulator Bcl-2 [Source:UniProtKB/Swiss-Prot;Acc:P10415] 7.63 9.81 2.19 4.55 1.35E-05 2.02E-04 1.34E-04 0.00E+00 -1.34E-04 4 365,hsa-miR-7,

Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit)(CPSF 25 kDa subunit)(Pre-mRNA cleavage factor Im 25 kDa subunit)(Nucleoside hsa-miR-18a,hsa-miR-222,hsa-miR-24,hsa- NUDT21 ENSG00000167005 diphosphate-linked moiety X motif 21)(Nudix motif 21) [S 6.91 9.22 2.31 4.97 2.62E-08 1.28E-06 1.24E-04 0.00E+00 -1.24E-04 4 miR-7, hsa-miR-135b,hsa-miR-18a,hsa-miR- RAB1B ENSG00000174903 Ras-related protein Rab-1B [Source:UniProtKB/Swiss-Prot;Acc:Q9H0U4] 7.56 8.30 0.74 1.67 2.16E-04 1.95E-03 0.00029367 0.00017153 0.58 -1.22E-04 4 24,hsa-miR-365,

Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1)(GPI-anchored membrane protein 1)(GPI-anchored protein p137)(GPI- p137)(p137GPI)(Cell cycle-associated protein 1)(Membrane component hsa-miR-132,hsa-miR-19a,hsa-miR- CAPRIN1 ENSG00000135387 chromosome 11 surface marker 1) [Source:UniProtKB/ 7.25 8.74 1.49 2.80 1.31E-05 1.96E-04 9.58E-05 0.00E+00 -9.58E-05 4 222,hsa-miR-7, CAP-Gly domain-containing linker protein 1 (Restin)(Cytoplasmic linker protein 170 alpha-2)(CLIP-170)(Reed-Sternberg intermediate filament- associated protein)(Cytoplasmic linker protein 1) hsa-miR-130b,hsa-miR-19a,hsa-miR- CLIP1 ENSG00000130779 [Source:UniProtKB/Swiss-Prot;Acc:P30622] 6.56 7.41 0.84 1.79 5.65E-05 6.46E-04 9.25E-05 0.00E+00 -9.25E-05 4 200b,hsa-miR-7, Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) hsa-miR-18a,hsa-miR-19a,hsa-miR- SEC61A1 ENSG00000058262 [Source:UniProtKB/Swiss-Prot;Acc:P61619] 7.88 8.94 1.05 2.07 1.11E-04 1.12E-03 0.00E+00 1.97E-04 1.97E-04 4 218,hsa-miR-7, G-rich sequence factor 1 (GRSF-1) [Source:UniProtKB/Swiss- hsa-miR-19a,hsa-miR-21,hsa-miR-218,hsa- GRSF1 ENSG00000132463 Prot;Acc:Q12849] 6.91 8.34 1.43 2.69 2.68E-05 3.51E-04 0.00E+00 2.43E-04 2.43E-04 4 miR-27a, Glutaminase kidney isoform, mitochondrial Precursor (GLS)(EC 3.5.1.2)(L- glutamine amidohydrolase)(K-glutaminase) [Source:UniProtKB/Swiss- hsa-miR-132,hsa-miR-155,hsa-miR-21,hsa- GLS ENSG00000115419 Prot;Acc:O94925] 7.00 8.31 1.31 2.48 3.78E-04 3.07E-03 0.00035826 0.00064888 1.81 2.91E-04 4 miR-7, DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) hsa-miR-155,hsa-miR-19a,hsa-miR-21,hsa- SATB1 ENSG00000182568 [Source:UniProtKB/Swiss-Prot;Acc:Q01826] 8.55 9.38 0.83 1.78 5.63E-04 4.28E-03 9.76E-05 0.00052341 5.36 4.26E-04 4 miR-7,

Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1)(GPI-anchored membrane protein 1)(GPI-anchored protein p137)(GPI- p137)(p137GPI)(Cell cycle-associated protein 1)(Membrane component hsa-miR-132,hsa-miR-19a,hsa-miR- CAPRIN1 ENSG00000135387 chromosome 11 surface marker 1) [Source:UniProtKB/ 7.25 8.74 1.49 2.80 1.31E-05 1.96E-04 0.00E+00 5.57E-04 5.57E-04 4 222,hsa-miR-7, EH domain-containing protein 1 (Testilin)(hPAST1) EHD1 ENSG00000110047 [Source:UniProtKB/Swiss-Prot;Acc:Q9H4M9] 6.91 6.52 -0.38 -1.30 2.09E-04 1.89E-03 0.00109845 0.00033365 0.30 -7.65E-04 3 hsa-miR-155,hsa-miR-21,hsa-miR-7,

Serine-protein kinase ATM (EC 2.7.11.1)(Ataxia telangiectasia ATM ENSG00000149311 mutated)(A-T, mutated) [Source:UniProtKB/Swiss-Prot;Acc:Q13315] 8.13 6.63 -1.50 -2.82 4.44E-04 3.50E-03 0.00036035 7.57E-05 0.21 -2.85E-04 3 hsa-miR-132,hsa-miR-18a,hsa-miR-21, Cyclic AMP-responsive element-binding protein 1 (cAMP-responsive element-binding protein 1)(CREB-1) [Source:UniProtKB/Swiss- CREB1 ENSG00000118260 Prot;Acc:P16220] 7.29 8.41 1.12 2.17 1.21E-03 7.96E-03 1.67E-04 0.00E+00 -1.67E-04 3 hsa-miR-155,hsa-miR-27a,hsa-miR-7, Protein kinase C alpha type (PKC-alpha)(PKC-A)(EC 2.7.11.13) PRKCA ENSG00000154229 [Source:UniProtKB/Swiss-Prot;Acc:P17252] 6.66 7.61 0.95 1.93 3.05E-04 2.58E-03 1.49E-04 0.00E+00 -1.49E-04 3 hsa-miR-200b,hsa-miR-24,hsa-miR-7, Centrosomal protein of 41 kDa (Cep41)(Testis-specific gene A14 TSGA14 ENSG00000106477 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9BYV8] 6.18 6.84 0.66 1.58 2.66E-04 2.30E-03 1.17E-04 0.00E+00 -1.17E-04 3 hsa-miR-155,hsa-miR-200b,hsa-miR-7,

RAB8B ENSG00000166128 Ras-related protein Rab-8B [Source:UniProtKB/Swiss-Prot;Acc:Q92930] 7.50 9.41 1.91 3.76 3.74E-06 7.18E-05 1.03E-04 0.00E+00 -1.03E-04 3 hsa-let-7f,hsa-miR-19a,hsa-miR-218,

Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)(Oxidative stress- OXSR1 ENSG00000172939 responsive 1 protein) [Source:UniProtKB/Swiss-Prot;Acc:O95747] 6.62 8.01 1.39 2.61 2.52E-05 3.34E-04 0.0002095 0.00011126 0.53 -9.82E-05 3 hsa-miR-218,hsa-miR-24,hsa-miR-7,

Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3)(Long-chain acyl-CoA ACSL4 ENSG00000068366 synthetase 4)(LACS 4) [Source:UniProtKB/Swiss-Prot;Acc:O60488] 4.45 7.02 2.57 5.93 2.34E-08 1.17E-06 7.93E-05 0.00014178 1.79 6.25E-05 3 hsa-miR-132,hsa-miR-19a,hsa-miR-7,

Calcium/calmodulin-dependent protein kinase type II delta chain (CaM- kinase II delta chain)(CaM kinase II subunit delta)(CaMK-II subunit CAMK2D ENSG00000145349 delta)(EC 2.7.11.17) [Source:UniProtKB/Swiss-Prot;Acc:Q13557] 6.03 7.92 1.88 3.69 6.17E-06 1.07E-04 0.00016662 0.00023783 1.43 7.12E-05 3 hsa-miR-24,hsa-miR-27a,hsa-miR-7, Cell division cycle protein 27 homolog (CDC27Hs)(H-NUC) CDC27 ENSG00000004897 [Source:UniProtKB/Swiss-Prot;Acc:P30260] 6.58 8.16 1.58 2.99 1.34E-06 3.12E-05 0.00E+00 7.57E-05 7.57E-05 3 hsa-miR-200b,hsa-miR-27a,hsa-miR-363, Tumor protein D52 (Protein N8) [Source:UniProtKB/Swiss- TPD52 ENSG00000076554 Prot;Acc:P55327] 5.69 7.19 1.50 2.83 1.01E-05 1.60E-04 0.00E+00 9.12E-05 9.12E-05 3 hsa-miR-155,hsa-miR-18a,hsa-miR-218, Glia maturation factor beta (GMF-beta) [Source:UniProtKB/Swiss- GMFB ENSG00000197045 Prot;Acc:P60983] 6.50 8.00 1.49 2.81 6.82E-05 7.55E-04 0.00E+00 9.15E-05 9.15E-05 3 hsa-miR-132,hsa-miR-19a,hsa-miR-221, Leucine-rich repeat-containing protein 59 [Source:UniProtKB/Swiss- LRRC59 ENSG00000108829 Prot;Acc:Q96AG4] 5.80 7.20 1.40 2.64 1.74E-05 2.48E-04 0.00011345 0.00021429 1.89 1.01E-04 3 hsa-miR-155,hsa-miR-206,hsa-miR-7,

Zinc transporter ZIP14 Precursor (Zrt- and Irt-like protein 14)(ZIP- 14)(Solute carrier family 39 member 14)(LIV-1 subfamily of ZIP zinc SLC39A14 ENSG00000104635 transporter 4)(LZT-Hs4) [Source:UniProtKB/Swiss-Prot;Acc:Q15043] 5.55 6.95 1.40 2.64 2.07E-11 3.92E-09 0.00E+00 1.10E-04 1.10E-04 3 hsa-miR-200b,hsa-miR-218,hsa-miR-7, GTPase-activating protein and VPS9 domain-containing protein 1 (Rab5- activating protein 6)(GAPex-5) [Source:UniProtKB/Sw iss- GAPVD1 ENSG00000165219 Prot;Acc:Q14C86] 6.64 7.45 0.82 1.76 1.60E-03 9.91E-03 0.00E+00 1.18E-04 1.18E-04 3 hsa-miR-132,hsa-miR-218,hsa-miR-365, Protein transport protein Sec24C (SEC24-related protein C) SEC24C ENSG00000176986 [Source:UniProtKB/Swiss-Prot;Acc:P53992] 6.65 7.83 1.17 2.26 1.41E-05 2.09E-04 0.00014416 0.00029421 2.04 1.50E-04 3 hsa-miR-363,hsa-miR-7,hsa-miR-98, Importin subunit alpha-3 (Karyopherin subunit alpha-3)(SRP1- gamma)(Importin alpha Q2)(Qip2) [Source:UniProtKB/Sw iss- KPNA3 ENSG00000102753 Prot;Acc:O00505] 6.35 7.48 1.13 2.18 3.57E-04 2.93E-03 0.00E+00 2.26E-04 2.26E-04 3 hsa-miR-19a,hsa-miR-24,hsa-miR-27a,

Transferrin receptor protein 1 (TfR1)(TfR)(TR)(Trfr)(T9)(p90)(CD71 antigen) [Contains Transferrin receptor protein 1, serum form(sTfR)] TFRC ENSG00000072274 [Source:UniProtKB/Swiss-Prot;Acc:P02786] 6.68 8.67 2.00 3.99 3.09E-07 9.43E-06 0.00E+00 2.71E-04 2.71E-04 3 hsa-miR-210,hsa-miR-221,hsa-miR-7,

RAB7A ENSG00000075785 Ras-related protein Rab-7a [Source:UniProtKB/Swiss-Prot;Acc:P51149] 7.70 9.21 1.50 2.83 3.44E-04 2.85E-03 0.00022741 0.00051944 2.28 2.92E-04 3 hsa-miR-200b,hsa-miR-210,hsa-miR-7, Signal transducer and activator of transcription 3 (Acute-phase STAT3 ENSG00000168610 response factor) [Source:UniProtKB/Swiss-Prot;Acc:P40763] 8.25 10.36 2.11 4.31 1.80E-07 6.07E-06 0.00014697 0.00046114 3.14 3.14E-04 3 hsa-miR-130b,hsa-miR-21,hsa-miR-222,

Hypoxia up-regulated protein 1 Precursor (150 kDa oxygen-regulated HYOU1 ENSG00000149428 protein)(Orp150) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y4L1] 6.66 7.66 1.00 2.00 7.18E-05 7.88E-04 0.00023481 0.00056759 2.42 3.33E-04 3 hsa-miR-200b,hsa-miR-222,hsa-miR-27a, Eukaryotic translation initiation factor 2 subunit 3 (Eukaryotic translation initiation factor 2 subunit gamma)(eIF-2-gamma) EIF2S3 ENSG00000130741 [Source:UniProtKB/Swiss-Prot;Acc:P41091] 8.92 10.10 1.18 2.27 6.94E-04 5.07E-03 0.00023035 0.00063317 2.75 4.03E-04 3 hsa-miR-132,hsa-miR-221,hsa-miR-7, Ras-related protein Rap-1A Precursor (GTP-binding protein smg- p21A)(Ras-related protein Krev-1)(C21KG)(G-22K) RAP1A ENSG00000116473 [Source:UniProtKB/Swiss-Prot;Acc:P62834] 7.74 9.44 1.70 3.26 3.21E-05 4.07E-04 0.00E+00 7.03E-04 7.03E-04 3 hsa-miR-19a,hsa-miR-24,hsa-miR-7, Neuroblast differentiation-associated protein AHNAK (Desmoyokin) AHNAK ENSG00000124942 [Source:UniProtKB/Swiss-Prot;Acc:Q09666] 9.64 8.50 -1.14 -2.21 4.59E-05 5.45E-04 0.00576483 0.00066217 0.11 -5.10E-03 2 hsa-miR-200b,hsa-miR-7, W D repeat-containing protein 1 (Actin-interacting protein 1)(AIP1)(NORI- WDR1 ENSG00000071127 1) [Source:UniProtKB/Swiss-Prot;Acc:O75083] 8.34 9.43 1.09 2.13 1.27E-03 8.28E-03 0.00289651 0.00187238 0.65 -1.02E-03 2 hsa-miR-19a,hsa-miR-218, LMNB1 ENSG00000113368 Lamin-B1 [Source:UniProtKB/Swiss-Prot;Acc:P20700] 5.57 8.38 2.81 7.00 3.67E-11 6.22E-09 0.00290655 0.00192926 0.66 -9.77E-04 2 hsa-miR-218,hsa-miR-7, W D repeat-containing protein 1 (Actin-interacting protein 1)(AIP1)(NORI- WDR1 ENSG00000071127 1) [Source:UniProtKB/Swiss-Prot;Acc:O75083] 8.34 9.43 1.09 2.13 1.27E-03 8.28E-03 0.00260824 0.00165063 0.63 -9.58E-04 2 hsa-miR-19a,hsa-miR-218, Ras GTPase-activating-like protein IQGAP1 (p195) IQGAP1 ENSG00000140575 [Source:UniProtKB/Swiss-Prot;Acc:P46940] 6.34 7.44 1.09 2.13 4.36E-04 3.45E-03 0.00231484 0.00151929 0.66 -7.96E-04 2 hsa-miR-24,hsa-miR-7, LMNB2 ENSG00000176619 Lamin-B2 [Source:UniProtKB/Swiss-Prot;Acc:Q03252] 6.11 6.89 0.78 1.72 1.55E-09 1.25E-07 0.00129592 0.00061064 0.47 -6.85E-04 2 hsa-miR-24,hsa-miR-7, EF-hand domain-containing protein D2 (Swiprosin-1) EFHD2 ENSG00000142634 [Source:UniProtKB/Swiss-Prot;Acc:Q96C19] 7.64 6.88 -0.76 -1.70 2.47E-04 2.17E-03 0.00059136 0.00015226 0.26 -4.39E-04 2 hsa-let-7f,hsa-miR-7, DEK ENSG00000124795 Protein DEK [Source:UniProtKB/Swiss-Prot;Acc:P35659] 7.07 8.85 1.78 3.43 7.69E-05 8.33E-04 0.00079266 0.0004399 0.55 -3.53E-04 2 hsa-miR-155,hsa-miR-218, Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta)(eIF-2-beta) EIF2S2 ENSG00000125977 [Source:UniProtKB/Swiss-Prot;Acc:P20042] 6.12 9.05 2.93 7.60 6.79E-09 4.26E-07 3.14E-04 0.00E+00 -3.14E-04 2 hsa-miR-27a,hsa-miR-29b,

Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta POLDIP3 ENSG00000100227 interaction protein)(p46) [Source:UniProtKB/Swiss-Prot;Acc:Q9BY77] 7.37 8.21 0.84 1.79 1.35E-03 8.66E-03 3.12E-04 0.00E+00 -3.12E-04 2 hsa-miR-155,hsa-miR-365, Tumor protein D54 (hD54)(Tumor protein D52-like 2) TPD52L2 ENSG00000101150 [Source:UniProtKB/Swiss-Prot;Acc:O43399] 6.63 7.72 1.09 2.13 5.14E-06 9.25E-05 3.09E-04 0.00E+00 -3.09E-04 2 hsa-miR-210,hsa-miR-7, Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7)(Kynurenine-- oxoglutarate transaminase III)(Kynurenine aminotransferase III)(KATIII)(Cysteine-S-conjugate beta-lyase 2)(EC 4.4.1.13) CCBL2 ENSG00000137944 [Source:UniProtKB/Swiss-Prot;Acc:Q6YP21] 5.92 7.58 1.66 3.16 3.00E-04 2.54E-03 2.98E-04 0.00E+00 -2.98E-04 2 hsa-miR-27a,hsa-miR-7, Interferon-induced guanylate-binding protein 1 (Guanine nucleotide- binding protein 1)(GTP-binding protein 1)(GBP-1)(HuGBP-1) GBP1 ENSG00000117228 [Source:UniProtKB/Swiss-Prot;Acc:P32455] 6.01 7.38 1.37 2.59 1.45E-04 1.40E-03 0.00069571 0.0004419 0.64 -2.54E-04 2 hsa-miR-18a,hsa-miR-7, LIM domain-containing protein 2 [Source:UniProtKB/Swiss- LIMD2 ENSG00000136490 Prot;Acc:Q9BT23] 7.65 7.06 -0.59 -1.51 2.06E-04 1.88E-03 2.17E-04 0.00E+00 -2.17E-04 2 hsa-miR-19a,hsa-miR-24, Double-strand-break repair protein rad21 homolog (hHR21)(Nuclear matrix protein 1)(NXP-1)(SCC1 homolog) [Source:UniProtKB/Sw iss- RAD21 ENSG00000164754 Prot;Acc:O60216] 7.47 9.09 1.62 3.07 6.31E-05 7.10E-04 1.63E-04 0.00E+00 -1.63E-04 2 hsa-miR-155,hsa-miR-363, CALD1 ENSG00000122786 Caldesmon (CDM) [Source:UniProtKB/Swiss-Prot;Acc:Q05682] 6.37 6.77 0.40 1.32 9.53E-04 6.55E-03 1.63E-04 0.00E+00 -1.63E-04 2 hsa-miR-19a,hsa-miR-27a, Serine/threonine-protein phosphatase 2A regulatory subunit B' (PP2A, subunit B', PR53 isoform)(Phosphotyrosyl phosphatase activator)(PTPA) PPP2R4 ENSG00000119383 [Source:UniProtKB/Swiss-Prot;Acc:Q15257] 7.06 7.68 0.62 1.54 1.26E-03 8.21E-03 0.00022271 9.61E-05 0.43 -1.27E-04 2 hsa-miR-19a,hsa-miR-218, DAZ-associated protein 1 (Deleted in azoospermia-associated protein DAZAP1 ENSG00000071626 1) [Source:UniProtKB/Swiss-Prot;Acc:Q96EP5] 7.05 8.05 1.00 1.99 1.93E-06 4.20E-05 0.00028274 0.00016124 0.57 -1.22E-04 2 hsa-miR-218,hsa-miR-24, Sorcin (22 kDa protein)(CP-22)(V19) [Source:UniProtKB/Sw iss- SRI ENSG00000075142 Prot;Acc:P30626] 7.65 9.08 1.44 2.71 4.09E-05 4.95E-04 0.00030009 0.00018475 0.62 -1.15E-04 2 hsa-miR-18a,hsa-miR-24,

RAB21 ENSG00000080371 Ras-related protein Rab-21 [Source:UniProtKB/Swiss-Prot;Acc:Q9UL25] 6.83 8.09 1.26 2.40 3.85E-04 3.12E-03 1.04E-04 0.00E+00 -1.04E-04 2 hsa-miR-19a,hsa-miR-200b, Phospholipase A-2-activating protein (PLA2P)(PLAP) PLAA ENSG00000137055 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y263] 6.14 6.94 0.80 1.74 8.31E-05 8.85E-04 0.00021373 0.00012354 0.58 -9.02E-05 2 hsa-miR-19a,hsa-miR-27a,

Protein tyrosine phosphatase-like protein PTPLAD1 (Protein-tyrosine phosphatase-like A domain-containing protein 1)(Butyrate-induced PTPLAD1 ENSG00000074696 protein 1)(hB-ind1)(B-ind1) [Source:UniProtKB/Swiss-Prot;Acc:Q9P035] 5.74 7.17 1.43 2.70 2.97E-05 3.82E-04 0.00E+00 9.10E-05 9.10E-05 2 hsa-miR-206,hsa-miR-24,

Serpin H1 Precursor (Collagen-binding protein)(Colligin)(47 kDa heat shock protein)(Rheumatoid arthritis-related antigen RA-A47)(Arsenic- transactivated protein 3)(AsTP3)(Cell proliferation-inducing gene 14 SERPINH1 ENSG00000149257 protein) [Source:UniProtKB/Swiss-Prot;Acc:P50454] 6.07 7.52 1.45 2.72 1.27E-07 4.59E-06 0.00E+00 9.45E-05 9.45E-05 2 hsa-miR-24,hsa-miR-29b, C1orf25 ENSG00000121486 TRM1-like protein [Source:UniProtKB/Swiss-Prot;Acc:Q7Z2T5] 4.69 6.72 2.03 4.07 5.14E-07 1.42E-05 0.00E+00 9.45E-05 9.45E-05 2 hsa-miR-132,hsa-miR-135b,

Transcription elongation factor B polypeptide 1 (RNA polymerase II transcription factor SIII subunit C)(SIII p15)(Elongin 15 kDa TCEB1 ENSG00000154582 subunit)(Elongin-C)(EloC) [Source:UniProtKB/Swiss-Prot;Acc:Q15369] 7.92 9.62 1.70 3.25 1.37E-07 4.89E-06 0.00E+00 9.87E-05 9.87E-05 2 hsa-miR-132,hsa-miR-200b,

Amidophosphoribosyltransferase Precursor (ATase)(EC 2.4.2.14)(Glutamine phosphoribosylpyrophosphate PPAT ENSG00000128059 amidotransferase)(GPAT) [Source:UniProtKB/Swiss-Prot;Acc:Q06203] 5.02 7.32 2.30 4.92 1.01E-07 3.80E-06 0.00E+00 1.09E-04 1.09E-04 2 hsa-miR-132,hsa-miR-7, Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7)(Kynurenine-- oxoglutarate transaminase III)(Kynurenine aminotransferase III)(KATIII)(Cysteine-S-conjugate beta-lyase 2)(EC 4.4.1.13) CCBL2 ENSG00000137944 [Source:UniProtKB/Swiss-Prot;Acc:Q6YP21] 5.92 7.58 1.66 3.16 3.00E-04 2.54E-03 0.00E+00 1.09E-04 1.09E-04 2 hsa-miR-27a,hsa-miR-7,

Retinol dehydrogenase 11 (EC 1.1.1.-)(Retinal reductase 1)(RalR1)(Prostate short-chain dehydrogenase/reductase 1)(Androgen- regulated short-chain dehydrogenase/reductase 1)(HCV core-binding RDH11 ENSG00000072042 protein HCBP12) [Source:UniProtKB/Swiss-Prot;Acc:Q8TC12] 6.32 8.23 1.91 3.75 4.49E-06 8.31E-05 0.00E+00 1.13E-04 1.13E-04 2 hsa-miR-365,hsa-miR-7, 60S ribosomal export protein NMD3 (hNMD3) [Source:UniProtKB/Swiss- NMD3 ENSG00000169251 Prot;Acc:Q96D46] 6.26 7.65 1.39 2.62 1.58E-04 1.50E-03 0.00E+00 1.13E-04 1.13E-04 2 hsa-miR-200b,hsa-miR-424, Proteasome-associated protein ECM29 homolog (Ecm29) KIAA0368 ENSG00000136813 [Source:UniProtKB/Swiss-Prot;Acc:Q5VYK3] 6.48 8.21 1.74 3.34 3.01E-06 6.05E-05 0.00E+00 1.13E-04 1.13E-04 2 hsa-miR-222,hsa-miR-7, Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6)(Glucosamine-6- phosphate deaminase 1)(GlcN6P deaminase 1)(GNPDA 1)(Oscillin) GNPDA1 ENSG00000113552 [Source:UniProtKB/Swiss-Prot;Acc:P46926] 5.73 7.81 2.08 4.21 1.92E-09 1.49E-07 0.00012285 0.0002372 1.93 1.14E-04 2 hsa-miR-200b,hsa-miR-7, Sphingosine-1-phosphate lyase 1 (SP-lyase)(hSPL)(EC 4.1.2.27)(Sphingosine-1-phosphate aldolase) [Source:UniProtKB/Sw iss- SGPL1 ENSG00000166224 Prot;Acc:O95470] 6.46 8.40 1.95 3.85 2.44E-08 1.22E-06 0.00E+00 1.17E-04 1.17E-04 2 hsa-miR-218,hsa-miR-24, Mitochondrial import receptor subunit TOM34 (hTom34)(Translocase of outer membrane 34 kDa subunit) [Source:UniProtKB/Swiss- TOMM34 ENSG00000025772 Prot;Acc:Q15785] 5.83 8.18 2.34 5.08 7.69E-09 4.68E-07 0.00E+00 1.33E-04 1.33E-04 2 hsa-miR-155,hsa-miR-24, Methylosome subunit pICln (Chloride conductance regulatory protein ICln)(I(Cln))(Chloride channel, nucleotide sensitive 1A)(Chloride ion current inducer protein)(ClCI)(Reticulocyte pICln) CLNS1A ENSG00000074201 [Source:UniProtKB/Swiss-Prot;Acc:P54105] 7.12 8.36 1.24 2.36 3.99E-05 4.84E-04 0.00E+00 1.37E-04 1.37E-04 2 hsa-miR-21,hsa-miR-7, Tumor necrosis factor, alpha-induced protein 3 (EC 3.-.-.-)(Putative DNA- binding protein A20)(Zinc finger protein A20) [Source:UniProtKB/Swiss- TNFAIP3 ENSG00000118503 Prot;Acc:P21580] 10.70 9.79 -0.91 -1.88 2.80E-04 2.40E-03 0.00E+00 1.65E-04 1.65E-04 2 hsa-miR-18a,hsa-miR-19a, Aspartate aminotransferase, cytoplasmic (EC 2.6.1.1)(Transaminase A)(Glutamate oxaloacetate transaminase 1) [Source:UniProtKB/Swiss- GOT1 ENSG00000120053 Prot;Acc:P17174] 5.70 8.10 2.39 5.26 5.84E-10 5.73E-08 0.00012551 0.00029973 2.39 1.74E-04 2 hsa-miR-155,hsa-miR-365, Exportin-5 (Exp5)(Ran-binding protein 21) [Source:UniProtKB/Sw iss- XPO5 ENSG00000124571 Prot;Acc:Q9HAV4] 5.75 7.86 2.10 4.30 4.78E-10 4.88E-08 0.00E+00 1.82E-04 1.82E-04 2 hsa-miR-218,hsa-miR-24, ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50)(TNF-alpha-stimulated ABC protein) [Source:UniProtKB/Sw iss- ABCF1 ENSG00000204574 Prot;Acc:Q8NE71] 7.12 7.72 0.60 1.52 3.26E-04 2.72E-03 0.00021773 0.00040478 1.86 1.87E-04 2 hsa-miR-18a,hsa-miR-424, Tumor protein D54 (hD54)(Tumor protein D52-like 2) TPD52L2 ENSG00000101150 [Source:UniProtKB/Swiss-Prot;Acc:O43399] 6.63 7.72 1.09 2.13 5.14E-06 9.25E-05 0.00E+00 1.89E-04 1.89E-04 2 hsa-miR-210,hsa-miR-7, Peptidyl-prolyl cis-trans isomerase, mitochondrial Precursor (PPIase)(Rotamase)(EC 5.2.1.8)(Cyclophilin F) [Source:UniProtKB/Swiss- PPIF ENSG00000108179 Prot;Acc:P30405] 7.00 8.07 1.07 2.10 3.18E-08 1.49E-06 0.00011797 0.00032754 2.78 2.10E-04 2 hsa-miR-27a,hsa-miR-7, MMS19 nucleotide excision repair protein homolog (hMMS19)(MMS19- like protein)(MET18 homolog) [Source:UniProtKB/Swiss- MMS19 ENSG00000155229 Prot;Acc:Q96T76] 7.05 8.08 1.02 2.03 1.58E-05 2.31E-04 0.00E+00 2.16E-04 2.16E-04 2 hsa-miR-132,hsa-miR-424,

ATP-binding cassette sub-family E member 1 (RNase L inhibitor)(Ribonuclease 4 inhibitor)(RNS4I)(2'-5'-oligoadenylate-binding ABCE1 ENSG00000164163 protein)(HuHP68) [Source:UniProtKB/Swiss-Prot;Acc:P61221] 6.37 8.31 1.93 3.82 8.91E-05 9.36E-04 0.0003064 0.00057997 1.89 2.74E-04 2 hsa-miR-130b,hsa-miR-19a, Prostaglandin E synthase 3 (EC 5.3.99.3)(Cytosolic prostaglandin E2 synthase)(cPGES)(Telomerase-binding protein p23)(Hsp90 co- chaperone)(Progesterone receptor complex p23) PTGES3 ENSG00000110958 [Source:UniProtKB/Swiss-Prot;Acc:Q15185] 8.04 9.44 1.41 2.65 3.46E-05 4.32E-04 0.00043235 0.00074007 1.71 3.08E-04 2 hsa-miR-18a,hsa-miR-19a, ATP-dependent RNA helicase DDX18 (EC 3.6.1.-)(DEAD box protein 18)(Myc-regulated DEAD box protein)(MrDb) [Source:UniProtKB/Sw iss- DDX18 ENSG00000088205 Prot;Acc:Q9NVP1] 7.04 8.58 1.54 2.92 6.27E-05 7.06E-04 0.00024496 0.0005615 2.29 3.17E-04 2 hsa-miR-222,hsa-miR-7, Ribosomal L1 domain-containing protein 1 (Cellular senescence- inhibited gene protein)(Protein PBK1)(CATX-11) RSL1D1 ENSG00000171490 [Source:UniProtKB/Swiss-Prot;Acc:O76021] 7.36 8.92 1.57 2.96 4.45E-05 5.30E-04 0.00023565 0.00068314 2.90 4.47E-04 2 hsa-miR-155,hsa-miR-7, ATP-citrate synthase (EC 2.3.3.8)(ATP-citrate (pro-S-)-lyase)(Citrate ACLY ENSG00000131473 cleavage enzyme) [Source:UniProtKB/Swiss-Prot;Acc:P53396] 6.94 8.23 1.29 2.45 2.90E-05 3.74E-04 0.0004879 0.00107125 2.20 5.83E-04 2 hsa-miR-27a,hsa-miR-7, Nucleosome assembly protein 1-like 1 (NAP-1-related protein)(hNRP) NAP1L1 ENSG00000187109 [Source:UniProtKB/Swiss-Prot;Acc:P55209] 8.54 9.65 1.12 2.17 2.34E-04 2.08E-03 0.00045538 0.00110527 2.43 6.50E-04 2 hsa-miR-132,hsa-miR-222,

Importin subunit beta-1 (Karyopherin subunit beta-1)(Nuclear factor KPNB1 ENSG00000108424 P97)(Importin-90) [Source:UniProtKB/Swiss-Prot;Acc:Q14974] 6.96 8.64 1.68 3.21 4.18E-07 1.19E-05 0.00069013 0.00135015 1.96 6.60E-04 2 hsa-miR-218,hsa-miR-27a, Clathrin heavy chain 1 (CLH-17) [Source:UniProtKB/Swiss- CLTC ENSG00000141367 Prot;Acc:Q00610] 6.67 8.57 1.90 3.74 1.80E-06 3.98E-05 0.00161846 0.00241096 1.49 7.93E-04 2 hsa-miR-19a,hsa-miR-24, Interferon regulatory factor 4 (IRF-4)(Lymphocyte-specific interferon regulatory factor)(LSIRF)(NF-EM5)(Multiple myeloma oncogene 1) IRF4 ENSG00000137265 [Source:UniProtKB/Swiss-Prot;Acc:Q15306] 6.03 10.11 4.09 17.00 6.54E-17 3.91E-13 0.00E+00 8.37E-04 8.37E-04 2 hsa-miR-27a,hsa-miR-7, T-complex protein 1 subunit epsilon (TCP-1-epsilon)(CCT-epsilon) CCT5 ENSG00000150753 [Source:UniProtKB/Swiss-Prot;Acc:P48643] 6.22 8.56 2.34 5.06 2.79E-08 1.34E-06 0.00067902 0.00165661 2.44 9.78E-04 2 hsa-miR-18a,hsa-miR-7, PHB ENSG00000167085 Prohibitin [Source:UniProtKB/Swiss-Prot;Acc:P35232] 7.71 9.08 1.38 2.60 7.89E-06 1.31E-04 0.00120586 0.00318836 2.64 1.98E-03 2 hsa-miR-27b,hsa-miR-7, SAM domain and HD domain-containing protein 1 (Dendritic cell-derived IFNG-induced protein)(DCIP)(Monocyte protein 5)(MOP-5) SAMHD1 ENSG00000101347 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y3Z3] 8.99 6.90 -2.09 -4.27 1.10E-07 4.09E-06 0.00344231 0.00131727 0.38 -2.13E-03 1 hsa-miR-155,

Protein unc-84 homolog B (Sad1/unc-84 protein-like 2)(Rab5-interacting UNC84B ENSG00000100242 protein)(Rab5IP) [Source:UniProtKB/Sw iss-Prot;Acc:Q9UH99] 8.13 7.31 -0.82 -1.77 1.79E-04 1.67E-03 0.0019225 0.00045687 0.24 -1.47E-03 1 hsa-miR-222, Heterogeneous nuclear ribonucleoprotein R (hnRNP R) HNRNPR ENSG00000125944 [Source:UniProtKB/Swiss-Prot;Acc:O43390] 8.13 9.29 1.16 2.23 3.63E-04 2.97E-03 9.95E-04 0.00E+00 -9.95E-04 1 hsa-miR-132, H1FX ENSG00000184897 Histone H1x [Source:UniProtKB/Swiss-Prot;Acc:Q92522] 6.66 7.56 0.89 1.86 1.67E-04 1.57E-03 0.00095111 0.00021998 0.23 -7.31E-04 1 hsa-miR-24, F-actin-capping protein subunit alpha-1 (CapZ alpha-1) CAPZA1 ENSG00000116489 [Source:UniProtKB/Swiss-Prot;Acc:P52907] 7.94 9.13 1.19 2.29 5.86E-04 4.41E-03 0.00134264 0.0007744 0.58 -5.68E-04 1 hsa-miR-7, Actin-related protein 3 (Actin-like protein 3) [Source:UniProtKB/Swiss- ACTR3 ENSG00000115091 Prot;Acc:P61158] 8.94 10.00 1.06 2.08 1.50E-04 1.44E-03 0.00181351 0.00128354 0.71 -5.30E-04 1 hsa-miR-200b, Lamin-B receptor (Integral nuclear envelope inner membrane LBR ENSG00000143815 protein)(LMN2R) [Source:UniProtKB/Swiss-Prot;Acc:Q14739] 7.21 8.17 0.96 1.95 8.81E-04 6.17E-03 0.00071092 0.00026531 0.37 -4.46E-04 1 hsa-miR-24, Aconitate hydratase, mitochondrial Precursor (Aconitase)(EC 4.2.1.3)(Citrate hydro-lyase) [Source:UniProtKB/Swiss- ACO2 ENSG00000100412 Prot;Acc:Q99798] 6.94 7.89 0.94 1.92 1.03E-04 1.06E-03 0.00122891 0.0008628 0.70 -3.66E-04 1 hsa-miR-7, UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9)(UDP-glucose pyrophosphorylase)(UDPGP)(UGPase) [Source:UniProtKB/Sw iss- UGP2 ENSG00000169764 Prot;Acc:Q16851] 6.73 8.13 1.40 2.64 1.46E-03 9.19E-03 3.48E-04 0.00E+00 -3.48E-04 1 hsa-miR-218, Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor)(p114-Rho- GEF)(p114RhoGEF)(Septin-associated RhoGEF)(SA-RhoGEF) ARHGEF18 ENSG00000104880 [Source:UniProtKB/Swiss-Prot;Acc:Q6ZSZ5] 7.38 6.59 -0.79 -1.73 1.66E-04 1.57E-03 2.88E-04 0.00E+00 -2.88E-04 1 hsa-miR-20a, Cytosolic non-specific dipeptidase (CNDP dipeptidase 2)(Glutamate carboxypeptidase-like protein 1)(Peptidase A) [Source:UniProtKB/Swiss- CNDP2 ENSG00000133313 Prot;Acc:Q96KP4] 6.55 7.31 0.76 1.70 5.19E-04 4.00E-03 0.00065037 0.00039842 0.61 -2.52E-04 1 hsa-miR-218,

Low molecular weight phosphotyrosine protein phosphatase (LMW- PTPase)(LMW-PTP)(EC 3.1.3.48)(Low molecular w eight cytosolic acid phosphatase)(EC 3.1.3.2)(Red cell acid phosphatase 1)(Adipocyte acid ACP1 ENSG00000143727 phosphatase) [Source:UniProtKB/Swiss-Prot;Acc:P24666] 7.32 8.41 1.09 2.13 2.98E-04 2.53E-03 2.45E-04 0.00E+00 -2.45E-04 1 hsa-let-7f, Signal transducer and activator of transcription 5B STAT5B ENSG00000173757 [Source:UniProtKB/Swiss-Prot;Acc:P51692] 7.13 8.21 1.09 2.12 7.86E-04 5.61E-03 2.30E-04 0.00E+00 -2.30E-04 1 hsa-miR-19a, Tropomodulin-3 (Ubiquitous tropomodulin)(U-Tmod) TMOD3 ENSG00000138594 [Source:UniProtKB/Swiss-Prot;Acc:Q9NYL9] 6.19 7.50 1.31 2.48 2.08E-04 1.89E-03 0.00046192 0.00025587 0.55 -2.06E-04 1 hsa-miR-365,

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform)(PP2A, subunit A, R1- PPP2R1B ENSG00000137713 beta isoform) [Source:UniProtKB/Swiss-Prot;Acc:P30154] 6.57 7.61 1.04 2.06 9.56E-04 6.56E-03 2.01E-04 0.00E+00 -2.01E-04 1 hsa-miR-7, DNA repair protein RAD50 (hRAD50)(EC 3.6.-.-) [Source:UniProtKB/Sw iss- RAD50 ENSG00000113522 Prot;Acc:Q92878] 5.86 7.99 2.13 4.39 2.49E-06 5.17E-05 1.93E-04 0.00E+00 -1.93E-04 1 hsa-miR-206, F-actin-capping protein subunit alpha-2 (CapZ alpha-2) CAPZA2 ENSG00000198898 [Source:UniProtKB/Swiss-Prot;Acc:P47755] 7.06 8.26 1.20 2.29 1.08E-03 7.21E-03 0.00039592 0.00020524 0.52 -1.91E-04 1 hsa-miR-218, Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1)(Sra-1)(p140sra-1) [Source:UniProtKB/Swiss- CYFIP1 ENSG00000068793 Prot;Acc:Q7L576] 5.75 6.31 0.56 1.47 3.16E-05 4.02E-04 1.78E-04 0.00E+00 -1.78E-04 1 hsa-miR-155,

Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) [Includes ATP-dependent dihydroxyacetone kinase(DHA kinase)(EC 2.7.1.29)(Glycerone kinase);FAD-AMP lyase (cyclizing)(EC DAK ENSG00000149476 4.6.1.15)(FAD-AMP lyase (cyclic FMN forming))(FMN cyclase) 6.44 7.15 0.71 1.63 2.04E-07 6.80E-06 1.75E-04 0.00E+00 -1.75E-04 1 hsa-miR-24, Microfibrillar-associated protein 1 [Source:UniProtKB/Swiss- MFAP1 ENSG00000140259 Prot;Acc:P55081] 4.94 6.96 2.03 4.08 1.00E-08 5.82E-07 1.70E-04 0.00E+00 -1.70E-04 1 hsa-miR-7,

High mobility group protein HMG-I/HMG-Y (HMG-I(Y))(High mobility group AT-hook protein 1)(High mobility group protein A1)(High mobility group HMGA1 ENSG00000137309 protein R) [Source:UniProtKB/Swiss-Prot;Acc:P17096] 6.96 7.89 0.92 1.90 4.27E-07 1.22E-05 0.00053941 0.00037023 0.69 -1.69E-04 1 hsa-miR-7,

TATA-binding protein-associated factor 2N (RNA-binding protein TAF15 ENSG00000172660 56)(TAFII68)(TAF(II)68) [Source:UniProtKB/Swiss-Prot;Acc:Q92804] 6.76 7.96 1.20 2.30 8.65E-05 9.13E-04 0.00037089 0.00020885 0.56 -1.62E-04 1 hsa-miR-132,

Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex ARPC5L ENSG00000136950 16 kDa subunit 2)(ARC16-2) [Source:UniProtKB/Swiss-Prot;Acc:Q9BPX5] 6.10 7.69 1.59 3.01 2.28E-05 3.09E-04 0.00039091 0.00022938 0.59 -1.62E-04 1 hsa-miR-7,

Fatty acid synthase (EC 2.3.1.85) [Includes [Acyl-carrier-protein] S- acetyltransferase(EC 2.3.1.38);[Acyl-carrier-protein] S- malonyltransferase(EC 2.3.1.39);3-oxoacyl-[acyl-carrier-protein] FASN ENSG00000169710 synthase(EC 2.3.1.41);3-oxoacyl-[acyl-carrier-protein] reductase( 6.41 7.11 0.70 1.63 4.80E-04 3.73E-03 1.54E-04 0.00E+00 -1.54E-04 1 hsa-miR-27a, Iduronate 2-sulfatase Precursor (EC 3.1.6.13)(Alpha-L-iduronate sulfate sulfatase)(Idursulfase) [Contains Iduronate 2-sulfatase 42 kDa chain;Iduronate 2-sulfatase 14 kDa chain] [Source:UniProtKB/Swiss- IDS ENSG00000010404 Prot;Acc:P22304] 7.61 7.06 -0.55 -1.47 5.62E-05 6.43E-04 1.48E-04 0.00E+00 -1.48E-04 1 hsa-miR-7, MYO1F ENSG00000142347 Myosin-If (Myosin-Ie) [Source:UniProtKB/Swiss-Prot;Acc:O00160] 7.00 6.25 -0.76 -1.69 1.16E-03 7.65E-03 0.00029392 0.00014935 0.51 -1.45E-04 1 hsa-miR-7, Glycogen debranching enzyme (Glycogen debrancher) [Includes 4-alpha- glucanotransferase(EC 2.4.1.25)(Oligo-1,4-1,4- glucantransferase);Amylo-alpha-1,6-glucosidase(Amylo-1,6- glucosidase)(EC 3.2.1.33)(Dextrin 6-alpha-D-glucosidase)] AGL ENSG00000162688 [Source:UniProtKB/Swiss-Pr 5.82 6.88 1.05 2.08 3.53E-04 2.90E-03 1.30E-04 0.00E+00 -1.30E-04 1 hsa-miR-155, Splicing factor, arginine/serine-rich 4 (Pre-mRNA-splicing factor SFRS4 ENSG00000116350 SRP75)(SRP001LB) [Source:UniProtKB/Swiss-Prot;Acc:Q08170] 7.64 8.67 1.02 2.03 2.46E-05 3.28E-04 1.24E-04 0.00E+00 -1.24E-04 1 hsa-miR-218, FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1)(FHOS)(Formin homology 2 domain-containing protein 1) FHOD1 ENSG00000135723 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y613] 6.05 6.92 0.87 1.83 1.48E-06 3.41E-05 1.22E-04 0.00E+00 -1.22E-04 1 hsa-miR-200b, Mitochondrial import inner membrane translocase subunit Tim13 TIMM13 ENSG00000099800 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5L4] 6.12 7.62 1.50 2.82 3.09E-05 3.95E-04 1.13E-04 0.00E+00 -1.13E-04 1 hsa-miR-24, Cohesin subunit SA-1 (Stromal antigen 1)(SCC3 homolog 1) STAG1 ENSG00000118007 [Source:UniProtKB/Swiss-Prot;Acc:Q8WVM7] 6.12 7.32 1.19 2.29 1.41E-03 8.96E-03 1.13E-04 0.00E+00 -1.13E-04 1 hsa-miR-27a, Signaling threshold-regulating transmembrane adapter 1 Precursor (Suppression-inducing transmembrane adapter 1)(SHP2-interacting transmembrane adapter protein)(gp30/40) [Source:UniProtKB/Swiss- SIT1 ENSG00000137078 Prot;Acc:Q9Y3P8] 6.87 8.10 1.23 2.34 1.09E-03 7.29E-03 1.13E-04 0.00E+00 -1.13E-04 1 hsa-miR-132,

DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1)(DNA-directed RNA polymerase II subunit E)(RPB5)(DNA-directed RNA polymerase II 23 kDa POLR2E ENSG00000099817 polypeptide)(XAP4) [Source:UniProtKB/Swiss-Prot;Acc:P19388] 6.79 8.07 1.28 2.42 2.34E-05 3.16E-04 1.13E-04 0.00E+00 -1.13E-04 1 hsa-miR-7,

28S ribosomal protein S7, mitochondrial Precursor (S7mt)(MRP- MRPS7 ENSG00000125445 S7)(bMRP-27a)(bMRP27a) [Source:UniProtKB/Sw iss-Prot;Acc:Q9Y2R9] 7.22 8.00 0.79 1.73 4.89E-04 3.79E-03 1.13E-04 0.00E+00 -1.13E-04 1 hsa-miR-221,

RAB10 ENSG00000084733 Ras-related protein Rab-10 [Source:UniProtKB/Swiss-Prot;Acc:P61026] 6.52 8.29 1.76 3.40 3.51E-05 4.36E-04 1.07E-04 0.00E+00 -1.07E-04 1 hsa-miR-7, Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Precursor (EC 1.2.4.1)(PDHE1-A type I) PDHA1 ENSG00000131828 [Source:UniProtKB/Swiss-Prot;Acc:P08559] 6.67 7.76 1.09 2.12 6.68E-06 1.14E-04 0.00033758 0.00023519 0.70 -1.02E-04 1 hsa-miR-155, Proteasome inhibitor PI31 subunit (hPI31) [Source:UniProtKB/Swiss- PSMF1 ENSG00000125818 Prot;Acc:Q92530] 7.46 8.28 0.81 1.75 6.34E-04 4.71E-03 0.00020827 0.00011109 0.53 -9.72E-05 1 hsa-miR-221, Isochorismatase domain-containing protein 1 [Source:UniProtKB/Swiss- ISOC1 ENSG00000066583 Prot;Acc:Q96CN7] 6.57 7.36 0.80 1.74 1.85E-04 1.71E-03 8.96E-05 0.00E+00 -8.96E-05 1 hsa-miR-424, Sorting nexin-6 (TRAF4-associated factor 2) [Source:UniProtKB/Swiss- SNX6 ENSG00000129515 Prot;Acc:Q9UNH7] 6.71 7.96 1.25 2.38 1.28E-03 8.31E-03 0.00017926 9.45E-05 0.53 -8.48E-05 1 hsa-miR-18a,

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform)(PP2A, B subunit, B56 delta isoform)(PP2A, B subunit, PR61 delta isoform)(PP2A, B subunit, R5 PPP2R5D ENSG00000112640 delta isoform) [Source:UniProtKB/Swiss-Prot;Ac 6.81 7.70 0.88 1.85 1.04E-04 1.06E-03 7.93E-05 0.00E+00 -7.93E-05 1 hsa-miR-218, Small nuclear ribonucleoprotein G (snRNP-G)(Sm protein G)(Sm-G)(SmG) SNRPG ENSG00000143977 [Source:UniProtKB/Swiss-Prot;Acc:P62308] 7.15 8.28 1.13 2.18 7.34E-05 8.03E-04 7.61E-05 0.00E+00 -7.61E-05 1 hsa-miR-155, Mps one binder kinase activator-like 2A (Mob1 homolog 2A)(MOB- MOBKL2A ENSG00000172081 LAK)(Protein Mob3A) [Source:UniProtKB/Swiss-Prot;Acc:Q96BX8] 8.05 8.98 0.93 1.91 2.28E-05 3.09E-04 7.61E-05 0.00E+00 -7.61E-05 1 hsa-miR-7, Kinesin-like protein KIF2A (Kinesin-2)(HK2) [Source:UniProtKB/Sw iss- KIF2A ENSG00000068796 Prot;Acc:O00139] 6.92 9.13 2.21 4.62 1.93E-05 2.71E-04 8.96E-05 7.57E-05 0.84 -1.39E-05 1 hsa-miR-218, Ribosomal protein S6 kinase alpha-1 (S6K-alpha 1)(EC 2.7.11.1)(90 kDa ribosomal protein S6 kinase 1)(p90-RSK 1)(pp90RSK1)(p90S6K)(Ribosomal S6 kinase 1)(RSK-1)(MAP kinase- activated protein kinase 1a)(MAPKAPK1A) [Source:UniProtKB/Sw iss- RPS6KA1 ENSG00000117676 Prot;Acc:Q15418] 6.69 7.09 0.41 1.33 3.36E-04 2.79E-03 8.96E-05 0.00013249 1.48 4.29E-05 1 hsa-miR-93, Large proline-rich protein BAT3 (HLA-B-associated transcript 3)(Protein BAT3 ENSG00000204463 G3) [Source:UniProtKB/Swiss-Prot;Acc:P46379] 7.49 8.32 0.83 1.78 1.93E-05 2.70E-04 7.93E-05 0.00015132 1.91 7.20E-05 1 hsa-miR-200b,

Putative deoxyribonuclease TATDN1 (EC 3.1.21.-)(Hepatocarcinoma high TATDN1 ENSG00000147687 expression protein) [Source:UniProtKB/Swiss-Prot;Acc:Q6P1N9] 6.69 8.44 1.74 3.35 3.16E-04 2.66E-03 0.00E+00 7.57E-05 7.57E-05 1 hsa-miR-7, Prolyl 4-hydroxylase subunit alpha-1 Precursor (EC 1.14.11.2)(4-PH alpha-1)(Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit P4HA1 ENSG00000122884 alpha-1) [Source:UniProtKB/Swiss-Prot;Acc:P13674] 4.94 8.72 3.78 13.74 2.61E-08 1.28E-06 0.00E+00 7.57E-05 7.57E-05 1 hsa-miR-21, Galactokinase (EC 2.7.1.6)(Galactose kinase) [Source:UniProtKB/Sw iss- GALK1 ENSG00000108479 Prot;Acc:P51570] 6.50 7.02 0.52 1.43 5.16E-06 9.28E-05 0.00E+00 7.57E-05 7.57E-05 1 hsa-miR-7, COP9 signalosome complex subunit 4 (Signalosome subunit 4)(SGN4)(JAB1-containing signalosome subunit 4) COPS4 ENSG00000138663 [Source:UniProtKB/Swiss-Prot;Acc:Q9BT78] 5.90 7.59 1.69 3.23 2.97E-04 2.52E-03 0.00027676 0.00035698 1.29 8.02E-05 1 hsa-miR-21, Dihydrofolate reductase (EC 1.5.1.3) [Source:UniProtKB/Swiss- DHFR ENSG00000228716 Prot;Acc:P00374] 4.40 8.49 4.09 16.99 3.86E-10 4.14E-08 0.00E+00 8.58E-05 8.58E-05 1 hsa-miR-18a, Double-stranded RNA-binding protein Staufen homolog 1 STAU1 ENSG00000124214 [Source:UniProtKB/Swiss-Prot;Acc:O95793] 7.28 8.28 1.01 2.01 7.84E-05 8.45E-04 0.00E+00 8.61E-05 8.61E-05 1 hsa-miR-7, Isocitrate dehydrogenase [NADP] cytoplasmic (IDH)(EC 1.1.1.42)(Cytosolic NADP-isocitrate dehydrogenase)(Oxalosuccinate decarboxylase)(NADP(+)-specific ICDH)(IDP) [Source:UniProtKB/Swiss- IDH1 ENSG00000138413 Prot;Acc:O75874] 5.69 6.17 0.48 1.39 1.22E-03 8.01E-03 0.00E+00 8.61E-05 8.61E-05 1 hsa-miR-155,

Serine/threonine-protein phosphatase 5 (PP5)(EC 3.1.3.16)(Protein PPP5C ENSG00000011485 phosphatase T)(PP-T)(PPT) [Source:UniProtKB/Swiss-Prot;Acc:P53041] 5.95 7.04 1.09 2.13 5.55E-05 6.38E-04 0.00E+00 9.07E-05 9.07E-05 1 hsa-miR-365, Craniofacial development protein 1 (Bucentaur) CFDP1 ENSG00000153774 [Source:UniProtKB/Swiss-Prot;Acc:Q9UEE9] 5.87 7.09 1.22 2.33 1.13E-04 1.14E-03 0.00E+00 9.07E-05 9.07E-05 1 hsa-miR-27a,

NUP43 ENSG00000120253 Nucleoporin Nup43 (p42) [Source:UniProtKB/Swiss-Prot;Acc:Q8NFH3] 4.74 7.33 2.59 6.03 3.39E-08 1.57E-06 0.00E+00 9.10E-05 9.10E-05 1 hsa-miR-155, BYSL ENSG00000112578 Bystin [Source:UniProtKB/Swiss-Prot;Acc:Q13895] 5.68 7.36 1.68 3.20 4.20E-12 1.09E-09 0.00E+00 9.10E-05 9.10E-05 1 hsa-miR-7, Mitochondrial import inner membrane translocase subunit TIM44 TIMM44 ENSG00000104980 Precursor [Source:UniProtKB/Swiss-Prot;Acc:O43615] 6.01 7.61 1.60 3.03 2.50E-07 7.95E-06 0.00E+00 9.12E-05 9.12E-05 1 hsa-miR-7, CDGSH iron sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein)(MitoNEET-related 1 protein)(Miner1) CISD2 ENSG00000145354 [Source:UniProtKB/Swiss-Prot;Acc:Q8N5K1] 6.73 8.27 1.54 2.91 1.20E-05 1.84E-04 0.00E+00 9.12E-05 9.12E-05 1 hsa-miR-7, Charged multivesicular body protein 5 (Chromatin-modifying protein 5)(Vacuolar protein-sorting-associated protein 60)(Vps60)(hVps60)(SNF7 domain-containing protein 2) CHMP5 ENSG00000086065 [Source:UniProtKB/Swiss-Prot;Acc:Q9NZZ3] 5.83 8.61 2.79 6.90 1.01E-06 2.46E-05 0.00E+00 9.12E-05 9.12E-05 1 hsa-miR-200b,

Uridine 5'-monophosphate synthase (UMP synthase) [Includes Orotate phosphoribosyltransferase(OPRTase)(EC 2.4.2.10);Orotidine 5'- phosphate decarboxylase(EC 4.1.1.23)(OMPdecase)] UMPS ENSG00000114491 [Source:UniProtKB/Swiss-Prot;Acc:P11172] 5.93 6.93 1.00 2.00 9.06E-05 9.49E-04 0.00E+00 9.47E-05 9.47E-05 1 hsa-miR-7, E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-)(E3 ubiquitin-protein ligase, HECT domain-containing 1)(Hyperplastic discs protein homolog)(hHYD)(Progestin-induced protein) [Source:UniProtKB/Sw iss- UBR5 ENSG00000104517 Prot;Acc:O95071] 6.39 7.76 1.37 2.59 7.28E-05 7.97E-04 0.00E+00 9.47E-05 9.47E-05 1 hsa-miR-27a, Thyroid receptor-interacting protein 6 (TRIP-6)(OPA-interacting protein 1)(Zyxin-related protein 1)(ZRP-1) [Source:UniProtKB/Sw iss- TRIP6 ENSG00000087077 Prot;Acc:Q15654] 6.41 7.24 0.84 1.79 2.29E-11 4.26E-09 0.00E+00 9.47E-05 9.47E-05 1 hsa-miR-7,

Serine/threonine-protein kinase 3 (EC 2.7.11.1)(STE20-like kinase MST2)(MST-2)(Mammalian STE20-like protein kinase 2)(Serine/threonine- STK3 ENSG00000104375 protein kinase Krs-1) [Source:UniProtKB/Swiss-Prot;Acc:Q13188] 5.14 5.98 0.84 1.79 7.12E-05 7.82E-04 0.00E+00 9.47E-05 9.47E-05 1 hsa-miR-21,

Protein RRP5 homolog (Programmed cell death protein 11)(NF-kappa-B- PDCD11 ENSG00000148843 binding protein)(NFBP) [Source:UniProtKB/Swiss-Prot;Acc:Q14690] 5.69 6.52 0.83 1.78 2.66E-05 3.49E-04 0.0001521 0.00024837 1.63 9.63E-05 1 hsa-miR-7,

ATP-binding cassette sub-family D member 3 (70 kDa peroxisomal ABCD3 ENSG00000117528 membrane protein)(PMP70) [Source:UniProtKB/Swiss-Prot;Acc:P28288] 5.30 7.68 2.38 5.21 6.54E-08 2.69E-06 0.00E+00 9.87E-05 9.87E-05 1 hsa-miR-19a,

FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1)(FACT 80 kDa subunit)(FACTp80)(Chromatin- specific transcription elongation factor 80 kDa subunit)(Structure- SSRP1 ENSG00000149136 specific recognition protein 1)(hSSRP1)(Recombination signal 6.68 8.82 2.13 4.39 5.46E-09 3.56E-07 0.00019002 0.00029401 1.55 1.04E-04 1 hsa-miR-424, GTP-binding protein SAR1b (GTBPB) [Source:UniProtKB/Swiss- SAR1B ENSG00000152700 Prot;Acc:Q9Y6B6] 5.72 7.60 1.88 3.69 7.42E-05 8.09E-04 0.00E+00 1.07E-04 1.07E-04 1 hsa-miR-363, Exportin-1 (Exp1)(Chromosome region maintenance 1 protein homolog) XPO1 ENSG00000082898 [Source:UniProtKB/Swiss-Prot;Acc:O14980] 6.67 8.18 1.51 2.85 2.72E-04 2.34E-03 0.00017501 0.00028457 1.63 1.10E-04 1 hsa-miR-27b, Serine hydroxymethyltransferase, cytosolic (SHMT)(Serine methylase)(EC 2.1.2.1)(Glycine hydroxymethyltransferase) SHMT1 ENSG00000176974 [Source:UniProtKB/Swiss-Prot;Acc:P34896] 5.52 6.78 1.26 2.39 2.08E-07 6.91E-06 0.00E+00 1.10E-04 1.10E-04 1 hsa-miR-218, 39S ribosomal protein L37, mitochondrial Precursor (L37mt)(MRP-L37) MRPL37 ENSG00000116221 [Source:UniProtKB/Swiss-Prot;Acc:Q9BZE1] 6.98 9.00 2.02 4.04 1.04E-08 6.01E-07 0.00E+00 1.10E-04 1.10E-04 1 hsa-miR-7, Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-)(DEAD box protein 52)(ATP-dependent RNA helicase ROK1-like) DDX52 ENSG00000141141 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2R4] 6.25 7.37 1.12 2.17 5.21E-04 4.01E-03 0.00E+00 1.10E-04 1.10E-04 1 hsa-miR-21, Exportin-7 (Exp7)(Ran-binding protein 16) [Source:UniProtKB/Sw iss- XPO7 ENSG00000130227 Prot;Acc:Q9UIA9] 5.74 6.94 1.20 2.30 7.85E-05 8.46E-04 0.00E+00 1.11E-04 1.11E-04 1 hsa-miR-7, DNA topoisomerase 2-alpha (EC 5.99.1.3)(DNA topoisomerase II, alpha TOP2A ENSG00000131747 isozyme) [Source:UniProtKB/Swiss-Prot;Acc:P11388] 3.13 8.68 5.54 46.59 4.59E-15 4.98E-12 0.00E+00 1.11E-04 1.11E-04 1 hsa-miR-21,

SURF4 ENSG00000148248 Surfeit locus protein 4 [Source:UniProtKB/Swiss-Prot;Acc:O15260] 7.79 9.59 1.80 3.48 2.53E-08 1.25E-06 0.00E+00 1.11E-04 1.11E-04 1 hsa-miR-27a,

Replication factor C subunit 5 (Activator 1 subunit 5)(Replication factor C 36 kDa subunit)(RF-C 36 kDa subunit)(RFC36)(Activator 1 36 kDa RFC5 ENSG00000111445 subunit)(A1 36 kDa subunit) [Source:UniProtKB/Swiss-Prot;Acc:P40937] 4.89 7.12 2.22 4.67 2.92E-08 1.39E-06 0.00E+00 1.13E-04 1.13E-04 1 hsa-miR-7, Component of gems 4 (Gemin-4)(p97) [Source:UniProtKB/Sw iss- GEMIN4 ENSG00000179409 Prot;Acc:P57678] 5.90 6.57 0.67 1.59 5.52E-05 6.34E-04 0.00E+00 1.13E-04 1.13E-04 1 hsa-miR-155, Proteasome subunit alpha type-4 (EC 3.4.25.1)(Proteasome component C9)(Macropain subunit C9)(Multicatalytic endopeptidase complex subunit C9)(Proteasome subunit L) [Source:UniProtKB/Swiss- PSMA4 ENSG00000041357 Prot;Acc:P25789] 6.73 8.83 2.10 4.29 8.37E-06 1.37E-04 0.00015187 0.00026574 1.75 1.14E-04 1 hsa-miR-7, AFG3-like protein 2 (EC 3.4.24.-)(Paraplegin-like protein) AFG3L2 ENSG00000141385 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y4W6] 6.08 6.93 0.86 1.81 9.00E-05 9.44E-04 0.00E+00 1.14E-04 1.14E-04 1 hsa-miR-27a, DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1)(EC 2.7.7.6)(DNA-directed RNA polymerase I subunit A)(DNA-directed RNA polymerase I largest subunit)(RNA polymerase I 194 kDa POLR1A ENSG00000068654 subunit)(RPA194)(A190) [Source:UniProtKB/Swiss-Prot;Acc:O 5.84 6.32 0.47 1.39 5.68E-04 4.31E-03 0.00E+00 1.16E-04 1.16E-04 1 hsa-miR-132, Ras-related protein Rab-27A (Rab-27)(GTP-binding protein Ram) RAB27A ENSG00000069974 [Source:UniProtKB/Swiss-Prot;Acc:P51159] 7.24 9.39 2.15 4.43 2.23E-07 7.26E-06 0.00E+00 1.17E-04 1.17E-04 1 hsa-miR-29b, Coiled-coil domain-containing protein 58 [Source:UniProtKB/Swiss- CCDC58 ENSG00000160124 Prot;Acc:Q4VC31] 5.75 8.80 3.05 8.30 1.62E-09 1.30E-07 0.00E+00 1.17E-04 1.17E-04 1 hsa-miR-24,

WD repeat-containing protein 36 (T-cell activation WD repeat-containing WDR36 ENSG00000134987 protein)(TA-WDRP) [Source:UniProtKB/Sw iss-Prot;Acc:Q8NI36] 6.14 8.01 1.86 3.64 9.13E-07 2.26E-05 0.00E+00 1.23E-04 1.23E-04 1 hsa-miR-7, Zinc finger CCCH domain-containing protein 14 (Renal carcinoma ZC3H14 ENSG00000100722 antigen NY-REN-37) [Source:UniProtKB/Sw iss-Prot;Acc:Q6PJT7] 6.01 7.34 1.34 2.52 3.70E-05 4.55E-04 0.00E+00 1.29E-04 1.29E-04 1 hsa-miR-132, Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2)(Dynein intermediate chain 2, cytosolic)(DH IC-2) DYNC1I2 ENSG00000077380 [Source:UniProtKB/Swiss-Prot;Acc:Q13409] 6.75 8.04 1.30 2.46 3.58E-04 2.94E-03 0.00E+00 1.29E-04 1.29E-04 1 hsa-miR-218, TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) TRAF1 ENSG00000056558 [Source:UniProtKB/Swiss-Prot;Acc:Q13077] 5.93 7.98 2.04 4.12 2.75E-09 2.01E-07 0.00E+00 1.32E-04 1.32E-04 1 hsa-miR-24,

SH2 domain-containing protein 2A (T cell-specific adapter protein)(TSAd)(VEGF receptor-associated protein)(SH2 domain- SH2D2A ENSG00000027869 containing adapter protein) [Source:UniProtKB/Swiss-Prot;Acc:Q9NP31] 6.10 7.86 1.76 3.40 7.00E-08 2.83E-06 0.00E+00 1.32E-04 1.32E-04 1 hsa-miR-24, DNA topoisomerase 1 (EC 5.99.1.2)(DNA topoisomerase I) TOP1 ENSG00000198900 [Source:UniProtKB/Swiss-Prot;Acc:P11387] 6.65 7.46 0.81 1.75 1.18E-04 1.18E-03 0.000107 0.00024057 2.25 1.34E-04 1 hsa-miR-24,

Enhancer of mRNA-decapping protein 3 (LSM16 homolog)(YjeF domain- containing protein 1)(YjeF N-terminal domain-containing protein EDC3 ENSG00000179151 2)(YjeF_N2)(hYjeF_N2) [Source:UniProtKB/Sw iss-Prot;Acc:Q96F86] 6.86 7.87 1.01 2.01 5.17E-06 9.28E-05 0.00E+00 1.38E-04 1.38E-04 1 hsa-miR-24,

Cleavage stimulation factor 50 kDa subunit (CSTF 50 kDa subunit)(CF-1 CSTF1 ENSG00000101138 50 kDa subunit)(CstF-50) [Source:UniProtKB/Swiss-Prot;Acc:Q05048] 6.07 7.61 1.54 2.91 2.06E-06 4.43E-05 0.00E+00 1.42E-04 1.42E-04 1 hsa-miR-155, DNA repair protein RAD50 (hRAD50)(EC 3.6.-.-) [Source:UniProtKB/Sw iss- RAD50 ENSG00000113522 Prot;Acc:Q92878] 5.86 7.99 2.13 4.39 2.49E-06 5.17E-05 0.00E+00 1.47E-04 1.47E-04 1 hsa-miR-206, Ataxin-2-like protein (Ataxin-2 domain protein)(Ataxin-2-related protein) ATXN2L ENSG00000168488 [Source:UniProtKB/Swiss-Prot;Acc:Q8WWM7] 6.62 7.86 1.24 2.36 4.14E-06 7.76E-05 0.00E+00 1.47E-04 1.47E-04 1 hsa-miR-18a, FAM98A ENSG00000119812 Protein FAM98A [Source:UniProtKB/Swiss-Prot;Acc:Q8NCA5] 5.56 6.52 0.95 1.94 4.38E-04 3.46E-03 0.00E+00 1.51E-04 1.51E-04 1 hsa-miR-27a,

Asparaginyl-tRNA synthetase, cytoplasmic (EC 6.1.1.22)(Asparagine-- NARS ENSG00000134440 tRNA ligase)(AsnRS) [Source:UniProtKB/Swiss-Prot;Acc:O43776] 7.26 9.14 1.88 3.69 6.75E-06 1.15E-04 0.00017131 0.00032827 1.92 1.57E-04 1 hsa-miR-155,

26S proteasome non-ATPase regulatory subunit 12 (26S proteasome PSMD12 ENSG00000197170 regulatory subunit p55) [Source:UniProtKB/Swiss-Prot;Acc:O00232] 5.93 7.71 1.78 3.42 3.92E-06 7.44E-05 0.00E+00 1.59E-04 1.59E-04 1 hsa-miR-132, WD repeat-containing protein 43 [Source:UniProtKB/Swiss- WDR43 ENSG00000163811 Prot;Acc:Q15061] 6.20 7.51 1.31 2.47 2.88E-04 2.46E-03 0.00E+00 1.60E-04 1.60E-04 1 hsa-miR-27a,

RuvB-like 2 (EC 3.6.1.-)(48 kDa TATA box-binding protein-interacting protein)(48 kDa TBP-interacting protein)(TIP49b)(Repressing pontin 52)(Reptin 52)(51 kDa erythrocyte cytosolic protein)(ECP-51)(TIP60- RUVBL2 ENSG00000183207 associated protein 54-beta)(TAP54-beta)(INO80 comple 6.15 7.63 1.48 2.78 8.12E-08 3.17E-06 0.00017878 0.00034351 1.92 1.65E-04 1 hsa-miR-27a, Lymphotoxin-alpha Precursor (LT-alpha)(TNF-beta)(Tumor necrosis factor ligand superfamily member 1) [Source:UniProtKB/Swiss- LTA ENSG00000226979 Prot;Acc:P01374] 6.32 8.76 2.43 5.40 6.38E-13 2.36E-10 0.00E+00 1.70E-04 1.70E-04 1 hsa-miR-7, Eukaryotic translation initiation factor 2A (eIF-2A)(65 kDa eukaryotic translation initiation factor 2A) [Source:UniProtKB/Swiss- EIF2A ENSG00000144895 Prot;Acc:Q9BY44] 7.20 8.60 1.40 2.65 2.62E-04 2.27E-03 9.25E-05 0.00026405 2.85 1.72E-04 1 hsa-miR-18a, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Precursor (EC 2.3.1.12)(Pyruvate dehydrogenase complex E2 subunit)(PDC- E2)(PDCE2)(E2)(Dihydrolipoamide S-acetyltransferase component of DLAT ENSG00000150768 pyruvate dehyd 6.30 7.62 1.32 2.49 1.14E-05 1.76E-04 0.00E+00 1.75E-04 1.75E-04 1 hsa-miR-365, Voltage-dependent anion-selective channel protein 2 (VDAC- 2)(hVDAC2)(Outer mitochondrial membrane protein porin 2) VDAC2 ENSG00000165637 [Source:UniProtKB/Swiss-Prot;Acc:P45880] 7.36 8.88 1.53 2.89 2.30E-06 4.85E-05 0.00037822 0.00055477 1.47 1.77E-04 1 hsa-miR-132, Basic leucine zipper and W2 domain-containing protein 1 (Protein Orf) BZW1 ENSG00000082153 [Source:UniProtKB/Swiss-Prot;Acc:Q7L1Q6] 8.39 9.84 1.45 2.74 3.25E-05 4.11E-04 0.00013543 0.00032019 2.36 1.85E-04 1 hsa-let-7f, DNA topoisomerase 2-alpha (EC 5.99.1.3)(DNA topoisomerase II, alpha TOP2A ENSG00000131747 isozyme) [Source:UniProtKB/Swiss-Prot;Acc:P11388] 3.13 8.68 5.54 46.59 4.59E-15 4.98E-12 0.00E+00 1.92E-04 1.92E-04 1 hsa-miR-21,

C10orf119 ENSG00000197771 UPF0557 protein C10orf119 [Source:UniProtKB/Swiss-Prot;Acc:Q9BTE3] 7.24 8.68 1.44 2.72 1.97E-05 2.75E-04 0.00E+00 1.97E-04 1.97E-04 1 hsa-miR-29b, Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X EIF1AX ENSG00000173674 isoform)(eIF-4C) [Source:UniProtKB/Swiss-Prot;Acc:P47813] 7.32 8.74 1.42 2.68 8.77E-04 6.14E-03 0.00E+00 2.01E-04 2.01E-04 1 hsa-miR-21, Sorting nexin-9 (SH3 and PX domain-containing protein 1)(Protein SDP1)(SH3 and PX domain-containing protein 3A) SNX9 ENSG00000130340 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y5X1] 6.34 8.83 2.49 5.62 1.95E-08 1.01E-06 0.00E+00 2.08E-04 2.08E-04 1 hsa-miR-7, 40 kDa peptidyl-prolyl cis-trans isomerase (PPIase)(Rotamase)(EC 5.2.1.8)(Cyclophilin-40)(CYP-40)(Cyclophilin-related protein) PPID ENSG00000171497 [Source:UniProtKB/Swiss-Prot;Acc:Q08752] 5.46 7.40 1.94 3.84 2.63E-06 5.41E-05 0.00E+00 2.11E-04 2.11E-04 1 hsa-miR-18a, La-related protein 1 (La ribonucleoprotein domain family member 1) LARP1 ENSG00000155506 [Source:UniProtKB/Swiss-Prot;Acc:Q6PKG0] 7.65 8.65 1.00 2.00 4.84E-05 5.69E-04 0.00E+00 2.16E-04 2.16E-04 1 hsa-miR-24,

E3 ubiquitin-protein ligase UHRF1 (EC 6.3.2.-)(Ubiquitin-like PHD and RING finger domain-containing protein 1)(Ubiquitin-like-containing PHD and RING finger domains protein 1)(Inverted CCAAT box-binding protein UHRF1 ENSG00000034063 of 90 kDa)(Transcription factor ICBP90)(Nucl 5.11 6.66 1.55 2.93 6.20E-11 9.45E-09 0.00E+00 2.23E-04 2.23E-04 1 hsa-miR-7,

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2)(EC 3.6.3.8)(Calcium pump 2)(Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform)(SR Ca(2+)-ATPase ATP2A2 ENSG00000174437 2)(Endoplasmic reticulum class 1/2 Ca(2+) ATPase) [Sour 7.00 7.98 0.98 1.97 4.35E-05 5.20E-04 0.00E+00 2.24E-04 2.24E-04 1 hsa-miR-363, Nuclear migration protein nudC (Nuclear distribution protein C homolog) NUDC ENSG00000090273 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y266] 6.87 7.45 0.58 1.50 1.91E-04 1.76E-03 0.00015789 0.00039443 2.50 2.37E-04 1 hsa-miR-132, 6-phosphofructokinase type C (EC 2.7.1.11)(Phosphofructokinase 1)(Phosphohexokinase)(Phosphofructo-1-kinase isozyme C)(PFK-C)(6- phosphofructokinase, platelet type) [Source:UniProtKB/Swiss- PFKP ENSG00000067057 Prot;Acc:Q01813] 6.53 8.50 1.98 3.94 2.13E-11 4.01E-09 0.00026234 0.00050086 1.91 2.39E-04 1 hsa-miR-20a, CTP synthase 1 (EC 6.3.4.2)(UTP--ammonia ligase 1)(CTP synthetase 1) CTPS ENSG00000171793 [Source:UniProtKB/Swiss-Prot;Acc:P17812] 6.16 7.90 1.74 3.33 6.05E-07 1.62E-05 0.00E+00 2.51E-04 2.51E-04 1 hsa-miR-7, Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase)(HGPRT)(EC 2.4.2.8) [Source:UniProtKB/Sw iss- HPRT1 ENSG00000165704 Prot;Acc:P00492] 6.36 8.70 2.34 5.05 1.52E-07 5.32E-06 0.00E+00 2.52E-04 2.52E-04 1 hsa-miR-19a, Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1)(eRF1)(TB3-1)(Protein Cl1) [Source:UniProtKB/Sw iss- ETF1 ENSG00000120705 Prot;Acc:P62495] 6.26 7.27 1.01 2.01 1.56E-03 9.68E-03 0.00E+00 2.62E-04 2.62E-04 1 hsa-miR-200b,

Importin subunit alpha-2 (Karyopherin subunit alpha-2)(SRP1- KPNA2 ENSG00000182481 alpha)(RAG cohort protein 1) [Source:UniProtKB/Swiss-Prot;Acc:P52292] 7.51 9.18 1.68 3.20 9.88E-08 3.74E-06 0.00E+00 2.79E-04 2.79E-04 1 hsa-miR-222, Exportin-2 (Exp2)(Importin-alpha re-exporter)(Chromosome segregation 1-like protein)(Cellular apoptosis susceptibility protein) CSE1L ENSG00000124207 [Source:UniProtKB/Swiss-Prot;Acc:P55060] 5.95 8.15 2.20 4.59 3.84E-07 1.11E-05 0.00028252 0.00059566 2.11 3.13E-04 1 hsa-miR-155, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a)(eRF3a)(G1 to S phase transition protein 1 homolog) [Source:UniProtKB/Swiss- GSPT1 ENSG00000103342 Prot;Acc:P15170] 7.48 8.60 1.13 2.18 1.64E-04 1.55E-03 0.00017882 0.00056151 3.14 3.83E-04 1 hsa-miR-27a,

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Precursor (EC 2.4.1.119)(Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit)(Ribophorin-1)(Ribophorin I)(RPN-I) RPN1 ENSG00000163902 [Source:UniProtKB/Swiss-Prot;Acc:P04843] 7.33 8.45 1.12 2.18 1.10E-04 1.11E-03 0.00081945 0.00121033 1.48 3.91E-04 1 hsa-miR-27a, Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein)(140 kDa nucleolar phosphoprotein)(Nopp140)(Nucleolar and coiled-body phosphoprotein 1)(HCV NS5A trans-regulated protein 13)(NS5ATP13) NOLC1 ENSG00000166197 [Source:UniProtKB/Swiss-Prot;Acc:Q14978] 5.95 7.57 1.62 3.08 8.87E-06 1.44E-04 0.00030622 0.00072845 2.38 4.22E-04 1 hsa-miR-155, T-complex protein 1 subunit gamma (TCP-1-gamma)(CCT- CCT3 ENSG00000163468 gamma)(hTRiC5) [Source:UniProtKB/Swiss-Prot;Acc:P49368] 6.49 7.87 1.38 2.60 3.65E-06 7.06E-05 0.00060687 0.00103784 1.71 4.31E-04 1 hsa-miR-24, Voltage-dependent anion-selective channel protein 1 (VDAC- 1)(hVDAC1)(Outer mitochondrial membrane protein porin 1)(Plasmalemmal porin)(Porin 31HL)(Porin 31HM) VDAC1 ENSG00000213585 [Source:UniProtKB/Swiss-Prot;Acc:P21796] 7.37 9.50 2.13 4.36 7.08E-09 4.37E-07 0.00039228 0.00087057 2.22 4.78E-04 1 hsa-miR-7,

T-complex protein 1 subunit delta (TCP-1-delta)(CCT-delta)(Stimulator CCT4 ENSG00000115484 of TAR RNA-binding) [Source:UniProtKB/Swiss-Prot;Acc:P50991] 7.37 9.52 2.15 4.43 1.11E-06 2.67E-05 0.00040592 0.00089192 2.20 4.86E-04 1 hsa-miR-7, Eukaryotic translation initiation factor 5B (eIF-5B)(Translation initiation EIF5B ENSG00000158417 factor IF-2) [Source:UniProtKB/Swiss-Prot;Acc:O60841] 5.39 6.93 1.54 2.91 1.01E-05 1.60E-04 0.00019559 0.0006817 3.49 4.86E-04 1 hsa-miR-200b,

Nucleoside diphosphate kinase A (NDP kinase A)(NDK A)(EC 2.7.4.6)(Tumor metastatic process-associated protein)(Metastasis inhibition factor nm23)(nm23-H1)(Granzyme A-activated DNase)(GAAD) NME1-NME2 ENSG00000011052 [Source:UniProtKB/Swiss-Prot;Acc:P15531] 6.53 8.49 1.96 3.88 5.51E-08 2.34E-06 0.00059392 0.00109262 1.84 4.99E-04 1 hsa-miR-206, Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1)(Tyrosyl--tRNA YARS ENSG00000134684 ligase)(TyrRS) [Source:UniProtKB/Swiss-Prot;Acc:P54577] 6.34 8.67 2.32 5.01 6.81E-09 4.26E-07 0.00035169 0.000867 2.47 5.15E-04 1 hsa-miR-7,

GTP-binding nuclear protein Ran (GTPase Ran)(Ras-related nuclear protein)(Ras-like protein TC4)(Androgen receptor-associated protein RAN ENSG00000132341 24) [Source:UniProtKB/Swiss-Prot;Acc:P62826] 8.56 10.15 1.58 3.00 8.11E-08 3.17E-06 0.00113924 0.0016887 1.48 5.49E-04 1 hsa-miR-21, stress-induced-phosphoprotein 1 (STIP1), mRNA [Source:RefSeq STIP1 ENSG00000225536 DNA;Acc:NM_006819] 5.63 7.09 1.46 2.76 2.52E-09 1.86E-07 0.00130927 0.00187723 1.43 5.68E-04 1 hsa-miR-7, Fructose-bisphosphate aldolase C (EC 4.1.2.13)(Brain-type aldolase) ALDOC ENSG00000109107 [Source:UniProtKB/Swiss-Prot;Acc:P09972] 6.68 9.36 2.68 6.41 1.79E-07 6.07E-06 0.00135036 0.00192739 1.43 5.77E-04 1 hsa-miR-7, Phosphoserine aminotransferase (EC 2.6.1.52)(Phosphohydroxythreonine aminotransferase)(PSAT) PSAT1 ENSG00000135069 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y617] 4.91 9.12 4.21 18.46 3.85E-16 1.06E-12 0.00E+00 6.02E-04 6.02E-04 1 hsa-miR-18a, Protein disulfide-isomerase A3 Precursor (EC 5.3.4.1)(Disulfide isomerase ER-60)(ERp60)(58 kDa microsomal protein)(p58)(ERp57)(58 kDa glucose-regulated protein) [Source:UniProtKB/Swiss- PDIA3 ENSG00000167004 Prot;Acc:P30101] 8.29 9.36 1.07 2.09 1.90E-04 1.75E-03 0.0027413 0.00343983 1.25 6.99E-04 1 hsa-miR-7, Alanyl-tRNA synthetase, cytoplasmic (EC 6.1.1.7)(Alanine--tRNA ligase)(AlaRS)(Renal carcinoma antigen NY-REN-42) AARS ENSG00000090861 [Source:UniProtKB/Swiss-Prot;Acc:P49588] 5.99 9.27 3.28 9.71 6.29E-11 9.55E-09 0.00025335 0.00096353 3.80 7.10E-04 1 hsa-miR-24,

Trifunctional purine biosynthetic protein adenosine-3 [Includes Phosphoribosylamine--glycine ligase(EC 6.3.4.13)(Glycinamide ribonucleotide synthetase)(GARS)(Phosphoribosylglycinamide GART ENSG00000159131 synthetase);Phosphoribosylformylglycinamidine cyclo-ligase(EC 6.3.3.1)( 6.10 8.83 2.73 6.65 6.50E-10 6.19E-08 0.00013855 0.00085412 6.16 7.16E-04 1 hsa-miR-7, Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog)(hG4-1)(ErbB3-binding protein 1) [Source:UniProtKB/Sw iss- PA2G4 ENSG00000170515 Prot;Acc:Q9UQ80] 7.98 10.04 2.06 4.17 2.55E-08 1.25E-06 0.00077661 0.00156058 2.01 7.84E-04 1 hsa-miR-7, Phosphoglycerate kinase 1 (EC 2.7.2.3)(Primer recognition protein 2)(PRP 2)(Cell migration-inducing gene 10 protein) PGK1 ENSG00000102144 [Source:UniProtKB/Swiss-Prot;Acc:P00558] 7.19 9.46 2.27 4.83 7.77E-08 3.07E-06 0.00496111 0.00577955 1.16 8.18E-04 1 hsa-miR-365, Multifunctional protein ADE2 [Includes Phosphoribosylaminoimidazole- succinocarboxamide synthase(EC 6.3.2.6)(SAICAR synthetase);Phosphoribosylaminoimidazole carboxylase(EC 4.1.1.21)(AIR carboxylase)(AIRC)] [Source:UniProtKB/Sw iss- PAICS ENSG00000128050 Prot;Acc:P22234] 5.72 9.85 4.13 17.49 5.07E-11 8.10E-09 0.0002648 0.00115002 4.34 8.85E-04 1 hsa-miR-7,

Ras GTPase-activating protein-binding protein 1 (EC 3.6.1.-)(G3BP- 1)(ATP-dependent DNA helicase VIII)(HDH-VIII)(GAP SH3 domain- G3BP1 ENSG00000145907 binding protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q13283] 7.74 9.07 1.32 2.50 7.80E-05 8.43E-04 0.00055246 0.00145271 2.63 9.00E-04 1 hsa-miR-132, DNA replication licensing factor MCM6 (p105MCM) MCM6 ENSG00000076003 [Source:UniProtKB/Swiss-Prot;Acc:Q14566] 5.57 8.87 3.30 9.88 3.60E-11 6.13E-09 0.00E+00 9.38E-04 9.38E-04 1 hsa-miR-7, Nucleolar RNA helicase 2 (EC 3.6.1.-)(Nucleolar RNA helicase II)(Nucleolar RNA helicase Gu)(RH II/Gu)(Gu-alpha)(DEAD box protein DDX21 ENSG00000165732 21) [Source:UniProtKB/Swiss-Prot;Acc:Q9NR30] 6.61 8.45 1.84 3.59 7.44E-07 1.93E-05 0.0002034 0.00138686 6.82 1.18E-03 1 hsa-miR-218,

4F2 cell-surface antigen heavy chain (4F2hc)(Lymphocyte activation antigen 4F2 large subunit)(4F2 heavy chain antigen)(CD98 antigen) SLC3A2 ENSG00000168003 [Source:UniProtKB/Swiss-Prot;Acc:P08195] 7.33 9.47 2.14 4.40 4.01E-09 2.73E-07 0.00E+00 1.20E-03 1.20E-03 1 hsa-miR-7, T-complex protein 1 subunit beta (TCP-1-beta)(CCT-beta) CCT2 ENSG00000166226 [Source:UniProtKB/Swiss-Prot;Acc:P78371] 7.39 9.22 1.83 3.56 1.72E-06 3.83E-05 0.00093413 0.0025243 2.70 1.59E-03 1 hsa-miR-155, Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) HSPA2 ENSG00000126803 [Source:UniProtKB/Swiss-Prot;Acc:P54652] 6.66 7.21 0.55 1.46 5.14E-06 9.25E-05 0.00E+00 1.98E-03 1.98E-03 1 hsa-miR-19a,

EEF2 ENSG00000167658 Elongation factor 2 (EF-2) [Source:UniProtKB/Swiss-Prot;Acc:P13639] 9.96 10.95 0.99 1.98 2.08E-04 1.89E-03 0.00426787 0.00714762 1.67 2.88E-03 1 hsa-miR-155,

L-lactate dehydrogenase A chain (LDH-A)(EC 1.1.1.27)(LDH muscle subunit)(LDH-M)(Renal carcinoma antigen NY-REN-59)(Cell proliferation- LDHA ENSG00000134333 inducing gene 19 protein) [Source:UniProtKB/Swiss-Prot;Acc:P00338] 9.20 11.12 1.92 3.78 9.58E-09 5.59E-07 0.0014837 0.00488686 3.29 3.40E-03 1 hsa-miR-7, Tubulin beta chain (Tubulin beta-5 chain) [Source:UniProtKB/Swiss- TUBB ENSG00000196230 Prot;Acc:P07437] 8.17 10.77 2.60 6.06 4.97E-10 5.00E-08 0.00559537 0.00905271 1.62 3.46E-03 1 hsa-miR-200b, Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) HSPA8 ENSG00000109971 [Source:UniProtKB/Swiss-Prot;Acc:P11142] 10.33 11.19 0.86 1.81 4.46E-04 3.51E-03 0.00362139 0.00799438 2.21 4.37E-03 1 hsa-miR-365, Gamma-enolase (EC 4.2.1.11)(2-phospho-D-glycerate hydro- lyase)(Neural enolase)(Neuron-specific enolase)(NSE)(Enolase 2) ENO2 ENSG00000111674 [Source:UniProtKB/Swiss-Prot;Acc:P09104] 7.33 10.02 2.69 6.44 1.17E-07 4.29E-06 0.00595281 0.01546115 2.60 9.51E-03 1 hsa-miR-24,