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Pharmacythe College of Pharmacy, Nursing, & Allied Sciences Alumni News Fall ‘09

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Pharmacythe College of Pharmacy, Nursing, & Allied Sciences Alumni News Fall ‘09 NORTH DAKOTA STATE UNIVERSITY pharmacyTHE COLLEGE OF PHARMACY, NURSING, & ALLIED SCIENCES alumni news fall ‘09 Making a difference in the world Pg. 7 A leader in research 2 Becoming more diverse 8 Pharmacy by the numbers 15 1 Preparing students to become competent, caring, ethical health professionals and citizens. NDSU pharmacy research ranks 13th nationally nanofiber precursors. “The nanofiber is made from peptide. Hobbies away from NDSU: “Nature, quiet places, gardening It has the ability to detect an enzyme (urokinase) that is over and spending time with my son and my dog.” NDSU’s pharmacy program is ranked 13th in the United States University, University of Minnesota, University of Iowa and the expressed at the tumor site. We expect the success of this Awards: NDSU College of Pharmacy, Nursing, and Allied for the percent of doctoral faculty with National Institutes University of Florida. technology will bring protease imaging closer to the clinic, Sciences 2009 Researcher of the Year and 2008 Teacher of Health funding. The American Association of Colleges of and also will establish an individualized therapeutic cargo for of the Year Pharmacy determines the ranking based on National Institutes NDSU ranked 38th nationally for total National Institutes anti-tumor delivery, based on the protease expressions.” of Health funding for pharmacy schools. NDSU has 42 percent of Health grant dollars awarded per full-time equivalent faculty, Best research experience: design of the peptide delivery of full-time equivalent doctoral pharmacy faculty receiving just behind the University of Minnesota (34th) and the Stephen O’Rourke system and optical imaging agent funding from the National Institutes of Health. The 2008 University of Iowa (35th). Position: associate professor ranking is out of 112 schools of pharmacy. Greatest influence: Professor Stephen W. Hawking Arrival at NDSU: 1990 “This is a great acknowledgment of the quality and competitiveness Goals: “To develop a new type of nanomedicine for indi- The pharmacy program’s percentage of pharmaceutical sciences of our research within the Department of Pharmaceutical Sciences vidualized patient therapy.” Research interest: cellular mechanisms that promote the faculty with competitive National Institutes of Health funding and within our college,” said Charles Peterson, dean of the College Favorite medicine or prescription drug: “Penicillin. The exceeded many other prestigious research universities including of Pharmacy, Nursing, and Allied Sciences. “We have a great group relaxation and constriction of discovery of penicillin saved a lot of lives and this drug blood vessels the University of Maryland, University of Illinois at Chicago, of faculty, working very hard, and producing great results. They are is still very useful. When I was an undergraduate, I was University of North Carolina at Chapel Hill, The Ohio State competing successfully with the best in the nation.” taught that a good pharmacist should know the structure Process: O’Rourke is a cardio- of penicillin.” vascular pharmacologist who NDSU is one of 112 schools of pharmacy nationally accredited studies the measurement of the by the Accreditation Council for Pharmacy Education. Sadie Anderson Hobbies away from NDSU: downhill skiing, fishing and movement of ions, such as potassium, in and out of the cell Pharmaceutical Sciences faculty tennis through proteins called ion channels. He and his students use both mouse and human blood vessels for their research. Bin Guo has inspired me to pursue new cancer therapeutics to help Sanku Mallik Most recent research discovery: O’Rourke and research- patients who have cancer.” Position: assistant professor Position: professor ers in his laboratory have found that sirolimus increases Goals: “To understand the mechanisms that regulate cancer outward KATP current in human coronary arterial smooth Arrival at NDSU: 2003 Arrival at NDSU: 1998 cell apoptosis and to develop new and more effective treat- muscle cells. Research interest: programmed Research interest: design of ment for cancer.” Best research experience: “Watching the successes of cell death, also known as small molecules for use as Favorite medicine or prescription drug: “My favorite drug former students.” apoptosis, which is a cell suicide potential drugs and also the is Prilosec, the proton pump inhibitor for treating heart- program that occurs in both delivery and targeting of drugs Greatest influence: The National Institutes of Health and burn and ulcers, because the drug has a specific target – the normal and cancer cells to their sites of action through the American Heart Association proton pump. It is very safe and very effective. I hope some the use of liposomes Process: Guo looks at changes day there can be a drug like that for cancer.” Goals: “To uncover the mechanisms by which melatonin in the expression of genes to Process: Mallik is a synthetic regulates nitric oxide signaling in coronary arteries.” Hobbies away from NDSU: travel, fishing, skiing, swim- find those that are associated with programmed cell death and medicinal chemist who synthesizes compounds that can ming and reading Favorite medicine or prescription drug: “Nitric Oxide, and how they are regulated. This process is very important inhibit enzymes found in a variety of different disease states because of its importance in cardiovascular physiology in the regulation of normal cell processes and is directly Awards: 2009 Who’s Who in America, three research grants including cancer, infectious disease and high blood pressure. and pathophysiology.” from the National Institutes of Health and one grant from involved in the prevention and treatment of cancer. Most recent research discovery: Mallik and researchers in Hobbies away from NDSU: golf, fishing and reading Department of Defense his laboratory are trying to release drugs from lipid-based Most recent research discovery: Researchers from Guo’s Awards: Fellow of the American Heart Association lab published a paper in the June 2009 issue of Cancer nanoparticles (liposomes) only in the presence of enzymes Prevention Research, a top journal in the cancer prevention Benedict Law involved in cancer cell metastasis. They discovered the field. The paper explains that diindolylmethane (a molecule Position: assistant professor nanoparticles will release the drugs in the presence of Steven Qian found in cabbage and broccoli) can effectively prevent colon highly metastatic breast cancer cells. Arrival at NDSU: 2007 Position: assistant professor cancers in a mouse model when used together with another Best research experience: “I take it for granted that the Arrival at NDSU: 2005 butyrate (an agent found in fiber-rich food). Guo says the Research interest: development experiments may not work out in the first attempt. When diindolylmethane and butyrate combination can induce of clinical imaging techniques this happens, I sit with my students and we brainstorm Research interest: free radical significantly more apoptosis in colon cancers than either for the diagnostic detection together. When the experiment works, it is very satisfying.” oxidative damage within cells drug alone. of tumors and the role of antioxidants in Greatest influence: Anthony J. Pearson, professor and the prevention of this process Best research experience: “My best research experience Process: Law looks at the design Mallik’s doctoral supervisor at Case Western University and production of medical imag- Process: Qian uses sophisticated has occurred at NDSU. My lab has made a number of key Goals: “To reduce the metastasis of breast and prostate discoveries and published papers in top scientific journals ing agents which target specific spectroscopes known as electron markers on the surface of cancer cells. He is interested in cancer cells and to find a way to detect of cancer-associated paramagnetic resonance and including Cancer Research and the Journal of Biological enzymes without the use of biological antibodies.” Chemistry.” finding ways to use the markers for peptide and protein mass spectrometry to study the formation of free radicals drug delivery systems directly to the sites of the tumor. Favorite medicine or prescription drug: “Even though within cells and tissues, which helps determine the sites Greatest influence: “My doctoral mentor, Dr. Youcef we conduct research on disease treatment, I am a strong of oxidation within living systems. Rustum, at Roswell Park Cancer Institute in Buffalo, N.Y., Most recent research discovery: Law and researchers in his laboratory discovered a new type of nanomedicine called believer of prevention (this includes healthy eating and regular exercise). I do not have a favorite medicine.” 2 3 Most recent research discovery: Qian and researchers in leave the laboratory as experts in drug delivery research. Goals: “We are currently working on three potential targets compounds from plants used in traditional Chinese medi- his laboratory have recently characterized novel fatty acid They are highly recruited by pharmaceutical industries.” for the treatment of hypertension and cardiovascular dis- cine. We have demonstrated that blood with globin mRNA metabolites formed from a cyclooxygenase pathway, which Greatest influence: “My dad is the greatest influence who eases. Our objectives are to identify more therapeutic tar- removal could provide a practical platform for a cancer bio- provides a new mechanistic insight into lipid peroxida- instilled in me confidence and ability to imagine.” gets for the treatment
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