molecules Review From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones Madalena M. M. Pinto 1,2,* , Andreia Palmeira 1,2,†, Carla Fernandes 1,2,† , Diana I. S. P. Resende 1,2,† , Emília Sousa 1,2,† , Honorina Cidade 1,2,† , Maria Elizabeth Tiritan 1,2,3,† , Marta Correia-da-Silva 1,2,† and Sara Cravo 1,2,† 1 Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal;
[email protected] (A.P.);
[email protected] (C.F.);
[email protected] (D.I.S.P.R.);
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[email protected] (S.C.) 2 Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal 3 CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal * Correspondence:
[email protected]; Tel.: +351-966-092-514 † These authors (by alphabetic order) contributed equally to this work. Abstract: This work reviews the contributions of the corresponding author (M.M.M.P.) and her research group to Medicinal Chemistry concerning the isolation from plant and marine sources of xanthone derivatives as well as their synthesis, biological/pharmacological activities, formulation and analytical applications. Although her group activity has been spread over several chemical families with relevance in Medicinal Chemistry, the main focus of the investigation and research has Citation: Pinto, M.M.M.; Palmeira, been in the xanthone family.