UHN Research Snapshot

Appointed Researchers 458 Clinical Researchers 608 Total Researchers 1,066

Fellows 325 Graduate Students 495 Total Trainees 820

Research Support Staff 325 Institute Staff 1,798 Total Staff 2,123

Research Space 971,719 sq. ft.

Publications 3,418

Total Funding $381,043,935

University Health Network (UHN) includes the Princess Margaret Cancer Centre (PM Cancer Centre), Toronto General Hospital (TGH), Toronto Rehab (TR), Toronto Western Hospital (TWH) and the Michener Institute for Education at UHN. It has five research institutes: Krembil Research Institute (Krembil), PM Cancer Centre, Techna Institute for the Advancement of Technology for Health (Techna), Toronto General Research Institute (TGRI) and Toronto Rehabilitation Institute (TRI). The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN is a research hospital affiliated with the University of Toronto (UT) and is a member of the Toronto Academic Health Science Network (TAHSN). Breaking Barriers. Building Health.

Welcome Message 2

The origin of a macrophage 4 Finding the right path 6 One of these is not like the others 8 More than just clowning around 10 Guiding light for cancer surgery 12 Bringing it all together 14

Year in Funding 16 Year in Discovery 18 Discoveries to Reality 20 Research Distinctions 22 UHN Foundations 24

Research Institutes 28

Research Committees 40

External Sponsors 42

Financials 44

Research Trustee & Advisory Boards 46 Christopher Paige PhD, FCAHS, Senior Scientist, PM Cancer Centre (past Executive Vice President, Science and Research), UHN Sharing knowledge for better health

A surgeon, an engineer and a physicist are SCOPE (Seamless Care Optimizing the sitting at a bar—you may think a joke is Patient Experience), a revolutionary virtual coming but what they are discussing is deadly interprofessional health team program that serious: how to detect residual cancer cells aims to improve the patient experience by left behind after a primary tumour is resected. supporting primary care providers through a Failure to remove or kill these cells allows single point of access. the cancer to recur. However, by applying their collective knowledge they devise, and These are but two examples of the integrated eventually test, a device that replaces normal actions that take place every day at UHN. visible light with infrared light and the lurking More than 4,000 people engage in research cancer cells are revealed. and their expertise spans nearly all aspects of biomedical sciences, including biology, Even a wider mix of talent, including chemistry, physics, engineering, health health services researchers, health care services, informatics…and the list goes on. professionals, community clinicians, patient As our understanding of the complexity of advocates, pharmacists, and IT specialists, human disease has increased it has become came together to visualize and implement abundantly clear that our only hope at making

2 Welcome Message

Peter Pisters MD, FACS, President and Chief Executive Officer, UHN

progress towards preventing or reversing Despite these challenges, the imperative to disease relies on our ability to draw on the break barriers, share information and integrate combined knowledge of our diverse research different skill sets is growing. One can see workforce forming teams whose collective this in something as routine as analysis of skills match the complexity of their targets. data—every year new techniques and tools are developed that allow our researchers to This is only accomplished when barriers are more deeply probe the nature of normal and removed; and this task is not as easy as it diseased cells and tissues. By adopting high- might sound. The daily pressures of providing throughput technology able to analyze genes, health care or running research laboratories proteins, cells and populations, the volumes can lead to a single-minded focus leaving of data collected can only be understood by little bandwidth for group thinking. Granting similarly robust information analysis tools. agencies and promotion committees can Only by the application of these still evolving contribute to this by rewarding individual processes will critical relationships buried in impact and, certainly in the past, there was complex datasets be revealed. also an inclination of a few of our highly motivated, often brilliant, superstars to build We hope that you enjoy this year’s report, their own empires. which is all about how UHN breaks down barriers, integrates expertise and shares knowledge for better health. 3 The origin of a macrophage Study traces the “big bang” moment for certain immune cells

Let’s go back to the beginning. We each Dr. Clinton Robbins (pictured above) set out developed from one cell. This single cell to provide new insight on this subject. He went through rounds and rounds of divisions, focused on uncovering the origin of immune creating daughter cells with the same genetic cells that reside in blood vessels—known as material that eventually make up the distinct arterial macrophages. organs and tissues in the body. His research team analyzed the genetic But clearly, brains, muscles and bones are very profiles of macrophages at different stages of different from one another. Given that these life. Using various ‘fate mapping’ techniques, specialized organs arose from a common which involve tracing the lineage of cells ancestor cell, this raises the question as to during development in the womb or after birth, the moment at which each of the estimated they found that arterial macrophages actually 37.2 trillion cells in the human body had its have different origins depending on age. “big bang”—fulfilling its destiny of becoming a brain cell, muscle cell or bone cell.

4 In the embryo, arterial macrophages come formation of lesions that interfere with blood from a partially developed ‘precursor’ cell that flow; determining where these macrophages expresses a specific protein on its cell surface, come from and how they accumulate will known as CX3CR1. Immediately after birth, help identify new ways to stop or slow this however, they originate from a different type process.” of cell, an immune cell known as a monocyte that comes from the bone marrow. Finally, Tracing the origin of a cell in adulthood, arterial macrophages gain the ability to divide and regenerate; this enables type helps to understand its them to increase in number in the absence of both precursor cells and monocytes. role in health and disease.

“Our findings underscore the need for more Ensan S, et al. Nat Immunol. 2016 Feb. This work was supported by the Canadian Institutes of careful examination of the factors that maintain Health Research, the Ontario Lung Association macrophages in tissues,” explains Dr. Robbins. and the Toronto General & Western Hospital “Insights from these studies are critical for Foundation. C Robbins is the Peter Munk Chair in research into diseases such as atherosclerosis, Aortic Disease Research, M Cybulsky holds a Tier the underlying cause of virtually all heart 1 Canada Research Chair in Arterial Wall Biology diseases. In atherosclerosis, macrophages and Atherogenesis and A Gramolini holds a Tier 2 Canada Research Chair in Cardiovascular Proteomics accumulate in the arteries and lead to the and Molecular Therapeutics.

5 Finding the right path Peptides guide developing nerves toward brain vision centres

When light hits our eyes, it is transformed into are born, grow and connect with each other. an electrical signal. That signal travels along a These connections, which form the basic specialized cable—the optic nerve—to specific brain architecture required for us to interact brain regions that transform it into images, with the world around us, are made possible allowing us to see. by signalling molecules, including peptides (ie, molecules that are similar to proteins, but The optic nerve is not just one nerve, but is smaller). These compounds serve as beacons composed of around 1.5 million nerve fibres that guide how cells interact with each other. called retinal axons. In order for the vision system to function, these retinal axons must Retinal axons can be damaged or lost be guided and connected to highly specific in conditions like glaucoma, leading to brain regions—a process that occurs during irreversible blindness. A major barrier to development and is not well understood. treatment is a better understanding of how developing nerve fibres connect with the brain The process of brain development mirrors the regions responsible for processing vision, complexity of the human brain: billions of cells including the optic tectum. 6 Recent findings from into the correct layer of the optic tectum. the lab of Dr. Philippe N-RGMa serves as the gas pedal for axonal Monnier addressed this growth, while C-RGMa serves as the brake. problem by shedding These insights may help in the development light on how retinal axons of therapies aimed at repairing retinal axon are able to navigate the damage,” remarks Dr. Monnier. maze-like environment of the developing brain. The Image: Dr. Monnier is depicted enjoying art—an act that would be impossible without the correct research team found that neuronal connections. The paintings feature two two types of signalling molecules within the trainees that contribute to Dr. Monnier’s research Repulsive Guidance Molecule a (RGMa) family program (L-R: Hidekiyo Harada; Jason Charish). of peptides serve important yet opposing Superimposed over Jason Charish’s portrait is functions. The N-RGMa subtype promotes an illustration that emphasizes the maze-like deep projections, ensuring that developing complexity of the path linking the optic nerve with the visual centres in the brain. axons extend far enough into the optic tectum, while the C-RGMa subtype prevents growing Banerjee P, et al. Cell Death Differ. 2016 Mar. This axons from extending too far. Together, these work was supported by the Canadian Institutes of peptides ensure that developing nerve fibres Health Research, the University of Toronto Vision from the eye find the optic tectum layer. “Our Science Research Program and the Toronto General work has uncovered the peptides responsible & Western Hospital Foundation. for ensuring that retinal axons integrate 7 One of these is not like the others Drug targets cancer cells by mimicking viral infection

Things are not always what they seem. That decitabine targets colorectal cancer stem was what a team of researchers led by Dr. cells. These cancer stem cells are believed to Daniel De Carvalho found when they decided be responsible for disease relapse because to explore how a group of anticancer drugs, they are resistant to treatment and can known as DNA-demethylating agents, target multiply indefinitely. By targeting these cells, cancer cells. DNA-demethylating agents are decitabine has the potential to improve patient approved for use in some blood cancers and outcomes for colorectal cancer. are under evaluation for treating different types of solid tumours, including colorectal Dr. De Carvalho’s team found an unlikely cancer. Despite their use clinically, there has mechanism of action: the drug works by been ongoing debate about the mechanisms making the cells proliferate more slowly and that underlie their clinical efficacy. behave like they are infected with viruses. As a consequence of this, the cells are targeted Specifically, Dr. De Carvalho’s team explored and cleared by the immune system. how a DNA-demethylating agent known as

8 Importantly, the researchers found that this Image: Dr. De Carvalho is duplicated in the above strategy is effective against the hard-to-target image to show how similar cancer and normal cells appear to the immune system. The anti-cancer drug colorectal cancer stem cells. decitabine, represented by the mask, serves to flag cancer cells, enabling the immune system to target “By mimicking a viral infection, the immune and attack these harmful cells. system is tricked into ‘seeing’ the cancer cells as an infection that needs to be destroyed,” Roulois D, et al. Cell. 2015 Aug. This work was says Dr. De Carvalho. “Our work demonstrates supported by the Cancer Research Society, the Canadian Cancer Society, the Natural Sciences that viral mimicry is a viable anti-tumour and Engineering Research Council of Canada, the strategy.” Currently colorectal cancer recurs Ontario Institute for Cancer Research with funds in about half of patients and is among the top from the Province of Ontario, the University of three types of cancer diagnosed in Canada. Toronto McLaughlin Centre and The Princess Margaret Cancer Foundation. Future studies will be focused on determining whether combining viral mimicry with cancer Cancer cells treated with the immunotherapy—a treatment that stimulates the immune system—provides more clinical drug behave like they are benefits than either therapy alone. infected with viruses.

9 More than just clowning around Helping hands that enrich the lives of people with dementia

“There is no pill that can do this,” says Dr. Pia homes. Elder-clowns are professional Kontos, referring to the findings of her study performers who specialize in the art of that evaluated the effect of elder-clowns on clowning with individuals living with dementia. people living with dementia. In addition to completing formal studies in acting and the clowning arts, elder-clowns Dementia can lead to deficits in memory, receive training on how to interact with older language, attention, reasoning and judgement. adults living with dementia. Unlike their circus Often, people living with this illness can counterparts, they wear minimal make-up and become agitated, depressed and apathetic. colourful dress from the 1950s. Given that medications can alleviate only some of these symptoms and can have harmful Elder-clowns are brought into nursing homes side effects, researchers are investigating to enrich the lives of older adults with alternative approaches. A recent innovation in dementia by lessening social isolation, and arts-based approaches to dementia care is the providing opportunities to express creativity, introduction of elder-clowns into nursing playfulness and imagination. Their interactions with residents can include verbal, physical 10 and musical jests that incorporate humour, but was instead validated and supported by storytelling and empathy. Importantly, elder- the clowns. clowns tailor their interaction to the life histories of each person and to the person’s The findings of the study were two-fold: mood and responsiveness during each visit. it revealed that elder-clowning provides therapeutic benefits and dispelled the myth While the art of clowning was adapted for that people living with dementia are incapable the dementia population in the 1990s, there of meaningful interactions. By showing that is limited knowledge of its impact. To explore elder-clowning can provide real benefits, these this issue, Dr. Kontos led a study in which four findings will inform new care approaches that elder-clowns visited 23 nursing home residents aim to improve quality of life and enrich the living with moderate to severe dementia. lives of people living with dementia.

Dr. Kontos and her colleagues found significant Image: (R-L) Dr. Kontos, and elder-clowns Kathleen Le Roux and Phil Koole. When visiting nursing home reductions in agitation and increased quality residents, elder-clowns bring along ukuleles and of life in residents after 12 weeks of biweekly other props to support their interactions. elder-clown visits. They also observed that residents would respond to the elder-clowns Kontos P, et al. J Am Geriatr Soc. 2016 Feb and and engage with them by being deliberately Kontos P, et al. Dementia (London). 2015 Apr. This funny, playful and imaginative. The residents work was supported by the Canadian Institutes of Health Research and the Toronto Rehab Foundation. also expressed sadness, which is typically suppressed in conventional dementia care, 11 Nanoparticles combine imaging approaches to target tumours

Advanced imaging techniques are essential Until now, the combined use of these innovations to help guide the removal of techniques in the operating room for tumour tumours. Precisely identifying and removing and lymph node visualization has been limited a tumour is especially challenging in head & because multiple imaging agents are needed, neck cancer where the anatomy is complex and existing agents do not have the sensitivity and full of sensitive ‘at risk’ organs. Prior to and specificity needed for disease detection. cancer surgery, X-ray computed tomography Dr. Jinzi Zheng and her collaborators have (CT) is often used to construct a detailed found a way to improve the usefulness of three-dimensional image to help the surgeon these imaging methods by developing a single visualize the tumour within complex healthy injectable imaging agent that can be used for structures and to plan the optimal surgical both modalities. procedure for removal. Another imaging technique called fluorescence optical imaging Dr. Zheng and her team developed the agent is also being increasingly used for guidance by encapsulating, into a single nanoparticle, during surgery, to identify and locate cancer different imaging molecules that were that has spread to the lymph nodes. engineered for use in CT and fluorescence imaging. Data obtained from ten different experimental cancer models showed that the

12 new imaging agent improved sensitivity when approved with proven efficacy, which should locating the tumour, its boundaries and lymph help to accelerate the translation of this nodes where the cancer had infiltrated. development into clinical practice.

Explains Dr. Zheng, “This new technology is Ironically, the need for such advanced tumour particularly useful because it enables us to imaging agents is driven by improvements employ different imaging techniques prior to in screening and diagnosis. Finding disease and during surgery following one injection of earlier is better for the patient’s outcome, but the imaging agent. Our results are particularly challenges surgeons to remove tiny tumours promising and suggest that this agent could be that are often too small to find by touch. used to improve the localization, detection and Advances in the use of X-ray CT imaging removal of a wide range of cancers.” technology during surgery also creates a need for an agent that stays in the tumour for a Using a nanoparticle as the carrier also long time, which is a natural property of the ensured that the agents remained in the liposomes developed by Dr. Zheng. tumour long enough for pre- and intra-operative imaging. This is because nanoparticles Zheng J, et al. Biomaterials. 2015 Oct. This work was supported by the Fidani Family Chair in exploit defects in a tumour’s blood vessels Radiation Physics, the Kevin & Sandra Sullivan to increase their retention within the body. Chair in Surgical Oncology, the RACH Fund and The The nanoparticle components are individually Princess Margaret Cancer Foundation.

13 Bringing it all together New leadership takes research enterprise to the next level

Five research institutes. Almost one million He also sees an opportunity to promote a square feet of dedicated research space. Over unified culture of research across UHN as one thousand world-class researchers. Given a whole. “It’s time for us to realize the idea UHN’s standing as Canada’s largest research of a research hospital—as envisioned by hospital, leading an initiative to Break Barriers Dr. Chris Paige—and to really incorporate and Build Health is no small task. research into everything that we do at UHN.” A starting point for this is to capitalize on Dr. Bradly Wouters—UHN’s new Executive the valuable information that is constantly Vice President, Science and Research—is up being generated at UHN, such as that from to that challenge. diverse sources like heart monitors, genomic sequencers, ultrasound machines and patient Dr. Wouters assumed the role in October 2016 questionnaires. One of Dr. Wouters’ initial following a highly competitive international areas of focus will be to find new ways of search; but he is already well known capturing, interpreting and unifying data—and throughout UHN, having been at the institution weaving them seamlessly into the fabric of the for almost a decade. He was recruited from organization—to help secure UHN’s growth in Maastricht University to PM Cancer Centre as this era of data-driven discovery. a Senior Scientist in 2008, and he also served as PM Cancer Centre’s interim Director of Research is what defines us; Research from 2014 to 2016. His experience in these roles will undoubtedly help to achieve it’s what makes us different. his vision: to build a more cohesive research enterprise. “The mission at UHN is really twofold: to deliver the best possible care with the “I’m excited to create opportunities that bring knowledge that we have today and to the organization closer together,” explains recognize the limitations of our current Dr. Wouters. “I’m a big believer in group treatments in order to develop new solutions intelligence and team science, and I think that for tomorrow. Research is the only tool we this is really UHN’s competitive advantage. have to do this. That’s why I support research Our individual researchers are great, but they across the entire spectrum: from curiosity- would be great anywhere by themselves. driven discovery research that reveals new It’s the environment that elevates research insights into human biology to transformational opportunities and innovation to another level. clinical trials, health services research or This is one of the things that we’re going to rehabilitation programs that are changing be working on: eliminating the divisions that policy and the way that the government funds impede team science and fostering the unique medicine. Research is what defines us; it’s environment and synergistic relationships that what makes us different, and I can’t wait to accelerate integrative research across the see what we can accomplish when we face institution.” today’s greatest health issues together.”

14 15 Year in Funding A selection of UHN research funding milestones

Applying Genomics to Fight Leukemia Dr. Jean Wang was awarded $3.4 million from grow and lead to cancer recurrence. Genome Canada’s Genomic Applications To address this, Dr. Wang will use the GAPP Partnership Program (GAPP). The program funds to advance a promising therapeutic drug supports research and development projects for leukemia towards clinical trials. The agent, in genomics that address real-world challenges called SIRP-alpha-Fc, interferes with a protein and opportunities. called CD47 that is found on the surface of leukemia cells. CD47 shields the cells from the Leukemia is one such challenge: standard host’s immune system, enabling the leukemia chemotherapy treatments for the disease are cells to evade destruction; by blocking CD47, not completely effective. These regimens, SIRP-alpha-Fc removes this protection and which have remained essentially unchanged signals immune cells called macrophages to since the 1970s, do not completely destroy engulf and destroy leukemia cells. all of the leukemia cells—enabling them to re- The project is a collaborative effort that brings Genomics research is being together Dr. Wang, Dr. Jayne Danska (an immunogeneticist at SickKids) and Trillium translated into novel cancer Therapeutics Inc. (a biotech company based in Toronto). It was one of five projects nationwide immunotherapies. to be awarded funding from this GAPP round.

16 Federal Funding for Patient-Oriented Research UHN scientists are playing key roles in two of and Techna to enhance access to care for the five Strategy for Patient-Oriented Research those suffering from chronic pain and to (SPOR) Networks in Chronic Disease funded advance the translation of research into clinical this year. Awarded through the Canadian practice. Institutes of Health Research, the networks received $12.4 million each to develop The Diabetes and its Related Complications transformative and measureable improvements SPOR Network, led by UHN’s Dr. Gary for patients with chronic disease. Lewis, will create a national registry and risk assessment tools to develop effective, The Chronic Pain SPOR Network will bring evidence-based tests and preventative together researchers from Krembil Research strategies for diabetes and its related Institute, Toronto General Research Institute diseases.

Investment in Cancer Stem Cell Securing Cutting-Edge Infrastructure Research Through its John R. Evans Leaders Fund, the A research project led by Dr. John Dick was Canada Foundation for Innovation announced awarded $6.2 million over five years from the funding for over $1.5 million in infrastructure to highly competitive Terry Fox New Frontiers advance research at UHN. These projects have Program Project Grant. The award will be diverse aims: overcoming immunosuppression used to advance our understanding of cancer to fight infections and cancer; defining stemness, which is the ability of cancer cells the role of macrophages in cardiovascular to self-renew and generate more cancer cells. disease; examining retinal development, The project will be focused on uncovering injury and repair; preventing falls in vulnerable ways to improve the detection and treatment populations; targeting mitochondrial of three high-risk cancers: acute myeloid dysfunction in leukemia; and unravelling the leukemia, myeloma and brain cancer. mechanisms of joint damage in osteoarthritis.

17 Year in Discovery A selection of research publications from UHN

Arthritis and Heart Health Take the Bad Ankylosing spondylitis (AS) with the Good is a form of arthritis that Chemotherapy is an effective commonly affects the spine. treatment for early stage In addition to suffering from breast cancer. Despite chronic back pain, people with AS are at this, studies have shown that certain drugs increased risk of heart disease and stroke; can increase the risk of heart failure in older however, it is not clear whether these people women (>65). To date, these studies have not are also at risk for mortality as a consequence addressed whether these risks affect younger of these events. A recent study led by Dr. Nigil women (<65)—a demographic that comprises Haroon addressed this gap in knowledge. His the majority of people diagnosed with the research team analyzed health data from over disease. To determine whether younger 21,000 patients and found that those with AS women are also at risk, Dr. Paaladinesh are at higher risk for death from heart disease Thavendiranathan analyzed the health data of and stroke than those without AS. Major risk 18,540 women over the age of 18 that were factors for death include age and chronic treated for early-stage breast cancer. He found kidney disease. This indicates that screening that all women treated with chemotherapy— and treating modifiable risk factors could help regardless of age—are at increased risk for prevent vascular disease in people with AS. heart failure. He cautions that the benefits of Haroon NN, et al. Ann Intern Med. 2015 Sept. chemotherapy far outweigh the risks, and that monitoring younger women for heart disease may help curb these risks. Thavendiranathan P, et al. J Clin Oncol. 2016 Jul.

18 Two Sides to Excess Fluids Affect Sleep Recovery People with end-stage Recovering from renal disease (ESRD) have treatment in the malfunctioning kidneys and intensive care unit have to regularly undergo (ICU) is challenging. Dr. Margaret Herridge dialysis to manage fluid buildup. These people found that the success of ICU recovery could also often have sleep apnea, a potentially be predicted based on a patient’s age and serious disorder in which breathing repeatedly length of stay in the ICU. This model could pauses during sleep. One explanation for help tailor long-term rehabilitation plans. A this may be that excess fluids shift from the complementary study by Dr. Jill Cameron legs towards the head when lying down— focused on the challenges faced by caregivers restricting the airway. To test this possibility, of recovering ICU patients. She found that Dr. T Douglas Bradley used a method called caregivers experienced clinical depression, ultrafiltration to remove excess fluid in people which in some cases did not improve up to with ESRD. He found that this markedly one year later. These studies highlight the need improved sleep and reduced symptoms of to consider the experiences of the patient— sleep apnea. This suggests that targeting and the caregiver—during ICU recovery. fluid buildup is a potential treatment for sleep Herridge MS, et al. Am J Respir Crit Care Med. 2016 apnea. Lyons OD, et al. Am J Respir Crit Care Med. Oct. and Cameron JI, et al. New Engl J Med. 2016 2015 Jun. May.

Research Tool Senses Overcoming Tumour Damage Resistance The production of energy in Glioblastoma is a brain cancer the body is essential, but that is particularly resistant to it also generates by-products called reactive treatment. This is partly due oxygen species (ROS). If left unchecked, to a subtype of tumour cells that are capable ROS can cause significant damage to cells. of replicating themselves. Exactly what Fortunately, antioxidant pathways ‘scavenge’ enables some glioblastoma cells to regenerate ROS and stop harmful effects. To help is unknown. Drs. Mathieu Lupien and Peter researchers study these processes, Dr. Dirks (SickKids) have shed light on this by Jonathan Rocheleau developed a molecular exploring the function of a protein called sensor that reveals the balance between ROS MLL5. They found that in glioblastoma cells, and antioxidant pathways in a cell. The sensor, MLL5 represses the levels of another protein called Apollo-NADP+, measures this balance known as H3.3. In turn, reduced H3.3 levels with higher accuracy and precision than were found to cause DNA to become more existing systems. This tool will help shed light compact, which turns on genes involved in on a wide range of diseases associated with tumour regeneration. The team also identified ROS, which include diabetes and age-related two chemical compounds that may prevent cancers. Cameron WD, et al. Nat Methods. 2016 this process. Further development of these Apr. compounds may lead to new drugs to treat this aggressive type of cancer. Gallo M, et al. Cancer Cell. 2015 Dec.

19 Discoveries to Reality Real-life applications born from UHN research

AVROBIO Launches Gene Therapy Programs The UHN spinout company AVROBIO launched the enzyme alpha-galactosidase A. Deficiencies two programs based on research by Drs. in this enzyme result in defects in metabolism Christopher Paige and Jeffrey Medin (now that can cause pain, kidney failure and heart at the Medical College of Wisconsin). The disease. AVROBIO’s therapy involves isolating programs—which are ready for Phase I clinical cells from a Fabry disease patient, modifying trials—leverage cell and gene therapy platforms them by introducing a functional copy of the for cancer and rare diseases. gene and infusing them back into the patient.

The first program is developing a therapy Cell and gene therapy that triggers the immune system to detect and destroy cancer cells. A patient’s cancer platforms may offer innovative cells are isolated and genetically modified to produce an immune signalling molecule called therapies for patients with IL-12. The modified cells are then infused back into the patient; as they begin producing IL-12, cancer and Fabry disease. the immune system is activated to target and eliminate the cancer cells. AVROBIO raised $25 million in Series A financing, co-led by Atlas Venture, Clarus and The second program is developing a similar SV Life Sciences, towards accelerating the approach to treat Fabry disease, a rare genetic development of these programs. disorder. People with Fabry disease have genetic mutations that lead to reduced levels of

20 UHN Companies Awarded JLABS Residency Two UHN-based startup companies, AVROBIO performance of image-guided high-precision and Nanovista, were awarded residency at JLABS cancer therapies. The early-stage company was @ Toronto, Johnson & Johnson Innovation’s co-founded by Drs. Jinzi Zheng, David Jaffray and life sciences incubator. Located in the MaRS Christine Allen (UT). Discovery District, the facility houses 40,000 sq. ft. of space for emerging companies to move AVROBIO is focused on developing novel gene products along the path to commercialization. therapies for cancer and rare diseases. It was founded based on the work of Drs. Paige and Nanovista is developing multimodal visualization Medin (see page 20). agents that are designed to improve the

Medication Labelling System Licensed UHN’s Inventor of the Year 2015 A medication labelling system co-invented This annual award was presented to creators of by Drs. Ludwik Fedorko and Joe Fisher was BresoDx®—a device that is used to diagnose licensed to Assure Medical Systems Inc.—a sleep apnea at home—by UHN’s office of start-up company co-founded by Dr. Fedorko. The Technology Development and Commercialization system uses electronic barcoding to label the (TDC). At UHN’s annual general meeting, TDC’s medications that will be delivered via syringes Dr. John Reid (pictured third from the left) during surgeries. Each label is automatically presented the award to (L - R) Drs. Geoff Fernie, T populated with information including the drug Douglas Bradley and Hisham Alshaer. name, concentration and time of preparation. As such, the system significantly reduces the risks Because diagnosis of sleep apnea is traditionally of labelling errors and misinterpretation that arise carried out in a sleep laboratory, few people from traditional hand-written labels—improving undergo testing. The wireless, at-home features patient safety. of BresoDx® help overcome this barrier. The device is licensed to BresoTec Inc. and has received regulatory approval from Health Canada. 21 Research Distinctions Selected honours bestowed upon UHN researchers

Dr. Cheryl Arrowsmith Dr. Eleanor Fish Fellow, American Association for the Fellow, African Academy of Sciences Advancement of Science Dr. Herbert Gaisano Dr. Joanne Bargman Member, Order of Ontario 2016 International Distinguished Medal, National Kidney Foundation Dr. Mary Gospodarowicz 2016 O. Harold Warwick Prize, Canadian Cancer Dr. Tom Chau Society 2016 Jonas Salk Award, March of Dimes Canada Dr. Robin Green Dr. Angela M Cheung Tier 2 Canada Research Chair in Traumatic Brain Tier 1 Canada Research Chair in Musculoskeletal Injury – Cognitive Rehabilitation Neuroscience and Postmenopausal Health (Renewal)

Dr. Hance Clarke Dr. Nigil Haroon 2016 Early Career Award, Canadian Pain Society 2016 Young Investigator Award, Canadian Rheumatology Association Dr. Angela Colantonio Fellow, Canadian Academy of Health Sciences Dr. Susan Jaglal Fellow, Canadian Academy of Health Sciences Dr. Myron Cybulsky Tier 1 Canada Research Chair in Arterial Wall Dr. Kevin Kain Biology and Atherogenesis Tier 1 Canada Research Chair in Molecular Parasitology (Renewal) Dr. Abdallah Daar Fellow, African Academy of Sciences Dr. Marianne Koritzinsky 2016 Michael Fry Research Award, Radiation Dr. Tirone David Research Society 2016 Scientific Achievement Award, American Association for Thoracic Surgery Dr. Ren-Ke Li Fellow, International Academy of Cardiovascular Dr. John Dick Sciences 2016 Fellow, American Association for Cancer Research Academy

22 Dr. Aravind Namasivayam Dr. Pascal van Lieshout 2016 Excellence in Applied Research Award, 2016 Excellence in Applied Research Award, Speech-Language & Audiology Canada Speech-Language & Audiology Canada

Dr. Pamela Ohashi Dr. Donald Weaver Tier 1 Canada Research Chair in Tumour Immunity Tier 1 Canada Research Chair in Drug Design for and Immunotherapy (Renewal) Protein Misfolding Disorders

Dr. Milica Radisic Dr. Daniel Winer 2015 Hatch Innovation Award, Canadian Society Tier 2 Canada Research Chair in for Chemical Engineering Immunometabolism

Dr. Frank Rudzicz Dr. Gang Zheng 2016 Excellence in Applied Research Award, Fellow, American Institute for Medical and Speech-Language and Audiology Canada Biological Engineering

Dr. Michael Sefton 2016 Terumo Global Science Prize, Terumo Foundation for Life Sciences and Arts

Dr. Frances Shepherd Officer, Order of Canada

Dr. Katherine Siminovitch Fellow, Canadian Academy of Health Sciences

Dr. Catriona Steele 2016 Lifetime Achievement Award, Speech- Language & Audiology Canada

Dr. Antonio Strafella Tier 2 Canada Research Chair in Movement Disorders and Neuroimaging (Renewal)

Dr. Murray Urowitz Lifetime Achievement Award, Lupus Ontario

23 UHN Foundations

The Princess Margaret Cancer Foundation

Toronto General & Western Hospital Foundation

Toronto Rehab Foundation

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The Princess Margaret Cancer Foundation

Billion Dollar Challenge: the Home Stretch In April 2012, The Princess Margaret Cancer Conquer Cancer had another strong year, raising Foundation (The PMCF) embarked on the largest over $19.3 million with 4,853 riders and OneWalk single fundraising campaign in the history to Conquer Cancer made its debut with 4,523 of Canadian health care—the Billion Dollar participants raising over $7.7 million. Challenge. This five-year initiative aims to secure $1 billion to enable personalized cancer medicine Thanks to the cancer research enabled through at The Princess Margaret Cancer Centre. these programs and the generosity of the community, the landscape in cancer diagnosis The PMCF has met this challenge ahead of and treatment is changing rapidly. The Tumour schedule: in January 2017, the Foundation Immunotherapy Program led by Drs. Pamela announced that a total of $1,052,000,000 has Ohashi and Lillian Siu is an excellent example been raised, with $532 million coming from of how The Princess Margaret is leading the philanthropy and $520 million from grants secured way in personalized cancer medicine by testing by cancer centre researchers. promising new cancer therapies. This treatment harnesses the natural power of the immune The Foundation also achieved a new record in system to combat cancer growth, and is an net annual fundraising with a total of $104 million emerging anticancer strategy has already been raised. This includes $15.5 million raised for the shown to be effective at improving patient $50 million Research Campaign, which launched outcomes. in 2015. Left photo: The inaugural OneWalk to Conquer Cancer For the second consecutive year, The PMCF raised fundraiser united a powerful community of cancer an all-time record of $24.8 million in net income survivors and their supporters to raise money for from its lotteries through continuous innovation in cancer research. Right photo: An RCMP officer at the ticket purchase options, prizing and use of social 2016 Billion Dollar Challenge event. media to reach more people. The Enbridge Ride to

25

Toronto General & Western Hospital Foundation

Renamed Krembil Research Institute Honours Donor Giving The Krembils—Bob, Linda, Mark, Jake and bring tremendous hope to our patients who Stacey—are among Canada’s leading investors will ultimately be the beneficiaries of discovery in research. Their philanthropic support of research.” Toronto Western Hospital began with a gift that established the Krembil Family Chair in Dr. Donald Weaver, Krembil’s Director, sees the Neurology. That gift was a catalyst for building a Krembil family’s commitment as a driving force world-leading research program bar none. behind work in the Institute’s state-of-the art laboratories. “We have a saying here at Krembil: Nearly 20 years and $80 million later, that beacon If we’re not here to find a cure, then why the hell of excellence now exists with the renaming of are we here? The Krembils chuckle every time Toronto Western Hospital’s research arm to the I say it, but there’s an understanding between Krembil Research Institute (or simply ‘Krembil’)— us. They know the phrase is not hyperbole, and branding that coincided with a new, multi-million every time we get a little closer to solving the dollar pledge from the family last fall. mystery of these diseases, we can honestly say that it’s a combination of great science and great On November 13, 2015, Her Royal Highness, philanthropy that will help patients live not just Sophie, The Princess Edward, Countess of longer, but better lives.” Wessex, patron of Toronto Western Hospital, acknowledged the family’s generosity at a tribute Photo (L-R): Mark Krembil; Stacey Krembil; Lieutenant- event unveiling the Institute’s new name. Governor Elizabeth Dowdeswell; Jake Krembil; Sophie, The Princess Edward, Countess of Wessex; Linda “Our world-leading scientists now have a Krembil; and Bob Krembil. renewed sense of pride in their life’s work to find cures for diseases of the brain, spine, bones, joints and eyes,” she said. “And it will

26 UHN Foundations Toronto Rehab Foundation

Accelerating Concussion Treatment and Research Toronto Rehab’s new and unique Hull-Ellis recovery. Our rigorous evaluation of techniques Concussion and Research Clinic sees patients and treatments will enable the development of within one week of sustaining a brain injury— a best practice model that others can emulate providing care and management of their across the province, country and globally.” symptoms, and enabling research on their progress. To celebrate the first anniversary of the Hull- Ellis Clinic at Toronto Rehab in June, donors Donor support—including the TWIINS Gala that and volunteers joined Ron Ellis for breakfast raised $700,000—enabled the clinic to come and an informative session titled Concussion to fruition. The Hull-Ellis Clinic, aptly named in Across the Spectrum of Injury. The session honour of hockey legends Dennis Hull and Ron provided attendees with key information about Ellis, provides patients with a weekly assessment the resource and equipment needs required to and comprehensive care program, as well as advance the research mandate of the clinic. follow-ups at weeks 8, 12 and 16 post-injury. In addition to physician assessments, other Through donor support, scientists and clinicians assessments that measure cognition, balance are making an incredible difference in the lives and mobility, and mood and personality are of people who have experienced concussion and conducted. brain injury. Our community of supporters plays a key role in helping Toronto Rehab uphold its “Our goal is to find faster ways to help people position as the number one rehabilitation research recover and to prevent long-term complications of centre in the world. traumatic brain injury,” explains Dr. Mark Bayley, Medical Director of the Brain & Spinal Cord Photo: (L-R) Ron Ellis and Dennis Hull cut the Injury Research Program, who leads the clinic. ceremonial ribbon to officially open the Hull-Ellis “We want to identify the people who have the Concussion and Research Clinic. most challenging symptoms and accelerate their

27 UHN Research Institutes

Krembil Research Institute

Princess Margaret Cancer Centre

Techna Institute

Toronto General Research Institute

Toronto Rehabilitation Institute

28 Krembil Research Institute* *formerly the Toronto Western Research Institute

Senior Scientists 36 Fellows 42 Scientists 12 Graduate Students 76 Affiliate Scientists 16 Total Trainees 118 Emeritus 2 Clinician Investigator 31 Total Appointed Researchers 97 Clinical Researchers 122 Total Researchers 219

Research Space 146,568 sq. ft. Total Staff 275

External Funding $41,203,837 Publications 901

Research Council Director and Chair, Krembil Research Institute Donald Weaver Co-Director, Donald K. Johnson Eye Institute Valerie Wallace Division Head, Healthcare Outcomes & Research Elizabeth Badley Division Head, Fundamental Neurobiology Peter Carlen Division Head, Brain, Imaging & Behaviour – Systems Neuroscience Karen Davis Division Head, Genetics & Development James Eubanks Division Head, Orthopaedics; Director, Arthritis Program Nizar Mahomed Clinical Representative, Arthritis Program Robert Inman Chair, Trainee Affairs Committee Frances Skinner Executive Director, Research Operations Lisa Alcia Senior Vice President, UHN and Executive Lead, TWH (Interim) Janet Newton Executive Vice President, Science and Research* Christopher Paige *role filled by Bradly Wouters as of Oct 1, 2016 Researchers Brain, Imaging & Scientists Shuzo Sugita Genetics & Development Behaviour-Systems Jonathan Downar Michael Tymianski Emeritus Neuroscience Mojgan Hodaie Donald Weaver Charles Tator Senior Scientists Affiliate Scientists Scientists Senior Scientists Jonathan Brotchie Jonathan Dostrovsky Jérémie Lefebvre Cathy Barr Robert Chen Mark Guttman Ivan Radovanovic James Eubanks Karen Davis Walter Kucharczyk Taufik Valiante Michael Fehlings William Hutchison Affiliate Scientists Robert Inman Fundamental Sidney Kennedy Magdy Hassouna Mohit Kapoor Neurobiology Andres Lozano Liang Zhang Philippe Monnier Mary Pat McAndrews Senior Scientists Georg Zoidl Lyanne Schlichter David Mikulis Peter Carlen Elise Stanley Antonio Strafella Frances Skinner Florence Tsui

29 Krembil Research Institute

Joan Wither Clinician Investigators Ki Jinn Chin Karen Okrainec Scientists Mark Bernstein Frances Chung Christian Pagnoux W Mark Erwin Anuj Bhatia Maria Cino Philip Peng Nigil Haroon Michael Brent Paula Cripps-McMartin Vitor Pereira Lorraine Kalia Daniel Buchman Michael Cusimano Aleksandra Pikula Suneil Kalia Melanie Cohn J Roderick Davey Atul Prabhu Armand Keating Robert Devenyi J Martin del Campo Arun Prasad Affiliate Scientists Dean Elterman Michael Easterbrook Theodore Rabinovitch Arjun Sahgal Alfonso Fasano Sherif El-Defrawy Sidney Radomski Sowmya Viswanathan Susan Fox Richard Farb Sapna Rawal Kenneth Fung David Frost Shail Rawal Health Care & Outcomes Rajiv Gandhi Fred Gentili Aylin Reid Research Timothy Jackson Alberto Goffi Lisa Richardson Emeritus Sukhvinder Kalsi-Ryan Allan Gordon Rowena Ridout Murray Urowitz Efrem Mandelcorn Brent Graham Cheryl Rosen Senior Scientists Daniel Mandell Clement Hamani David Salonen Elizabeth Badley Shane McInerney Patricia Harvey Jorge Sanchez-Guerrero J David Cassidy Roger McIntyre Cheryl Jaigobin Paul Sandor Aileen Davis Renato Munhoz Harry Janssen Michael Schwartz Dafna Gladman Laura Passalent Sindhu Johnson Hemant Shah Nizar Mahomed Anahi Perlas Benjamin Kaasa Sanjay Siddha Scientist Fayez Quereshy Rita Kang Frank Silver Anthony Perruccio Y Raja Rampersaud Moira Kapral Martin Simons Affiliate Scientists David Rootman Hans Katzberg Shaun Singer Vinod Chandran Mohammed Shamji Ron Keren Jeffrey Singh Cheryl Cott Allan Slomovic Edward Keystone Mandeep Singh Paul Fortin David Tang-Wai Kyle Kirkham Sumeet Sodhi Monique Gignac Carmela Tartaglia Diana Kljenak Peter St George-Hyslop Rosemary Martino Zahi Touma Paul Kongkham Matthew Stanbrook Christian Veillette Stephen Kraft Amanda Steiman Patient-based Clinical M Elizabeth Wilcox Timo Krings Khalid Syed Research Mateusz Zurowski Richelle Kruisselbrink Peter Tai Senior Scientists Jeffrey Kwong Susan Tarlo Anthony Lang Clinical Researchers Jan Lackstrom Maria Tassone Colin Shapiro Ronit Agid Robert Lam Karel terBrugge Jamil Ahmad Wai-Ching Lam Karen Tu Vector Core Danielle Andrade Carolina Landolt- Lashmi Venkatraghavan Marticorena Herbert von Schroeder Senior Scientist Yaron Avitzur Johnny Lau Adam Weizman Jeffrey Medin Heather Baltzer Paul Binhammer Stephen Lewis Richard Wennberg Joel Lexchin Robert Willinsky Vision Science Jeff Bloom Claire Bombardier Mark Mandelcorn David H Wong Senior Scientists Pirjo Manninen David T Wong Christopher Hudson Arthur Bookman Vera Bril Samuel Markowitz Jean Wong Martin Steinbach Connie Marras Eric Yu Graham Trope Richard Brull Yvonne Buys Theodore Marras Valerie Wallace K Wayne Marshall Agnes Wong Simon Carette Leanne Casaubon Eric Massicotte Scientist Steven McCabe Jeremy Sivak Rodrigo Cavalcanti Jas Chahal Kenneth Melvin Affiliate Scientists Ali Naraghi Moshe Eizenman Clara Chan Vincent Chan Mary Ann Neary John Flanagan Ahtsham Niazi Brenda Gallie Kenneth Chapman Caroline Chessex Ivy Oandasan Angela C Cheung Darrell Ogilvie-Harris Angela M Cheung Allan Okrainec

30 Princess MargaretMargaret Cancer CentrCentree

Senior Scientists 48 Fellows 91 Scientists 16 Graduate Students 103 Affiliate Scientists 15 Total Trainees 194 Assistant Scientists 1 Total Appointed Researchers 80 CCRU Members 293 Total Researchers 373

Research Space 388,591 sq. ft. Total Staff 855

External Funding $154,058,701 Publications 1,312

Research Council on Oncology (RCO) Director, PM Cancer Centre; Chair, RCO; Chair, Executive Committee (Interim)* Bradly Wouters Executive Committee Mitsuhiko Ikura, Rama Khokha, Pamela Ohashi, Gary Rodin, Aaron Schimmer, Vuk Stambolic, Ming-Sound Tsao, Brian Wilson, Gang Zheng Chair, Appointments Committee Rama Khokha Medical Director, Cancer Program Mary Gospodarowicz Medical Director, Laboratory Medicine Program Runjan Chetty Head, CCRU Amit Oza Head, Medical Oncology and Hematology (Interim) Amit Oza Head, Radiation Medicine Fei-Fei Liu Chief, Surgical Oncology Jonathan Irish Executive Director, Research Operations Lisa Alcia Senior Vice President, UHN and Executive Lead, PM Cancer Centre Marnie Escaf Executive Vice President, Science and Research** Christopher Paige *role filled by Rama Khokha as of Oct 1, 2016. **role filled by Bradly Wouters as of Oct 1, 2016. Researchers Senior Scientists Razqallah Hakem Lothar Lilge Kenneth Aldape David Hedley Fei-Fei Liu Cheryl Arrowsmith Richard Hill Geoffrey Liu Sylvia Asa Naoto Hirano Mathieu Lupien Norman Boyd Doris Howell Tak Mak Robert Bristow Mitsuhiko Ikura Tracy McGaha David Brooks Norman Iscove Mark Minden Avijit Chakrabartty David Jaffray Benjamin Neel Gerald Devins Igor Jurisica Pamela Ohashi John Dick Gordon Keller Emil Pai Shereen Ezzat Rama Khokha Christopher Paige Lucia Gagliese Thomas Kislinger Linda Penn

31 Princess Margaret Cancer Centre

Gilbert Privé Eitan Amir Christine Cserti-Gazdewich Brian Raught Mostafa Atri Bernard Cummings Gary Rodin Michael Baker Marcelo Cypel Robert Rottapel Subrata Banerjee Gilda da Cunha Santos Aaron Schimmer David Barth Norma D’Agostino Vuk Stambolic Eric Bartlett Andrei Damyanovich James Till Andrew Bayley Gail Darling Ming-Sound Tsao Nathan Becker Laura Dawson I Alex Vitkin Philippe Bedard John de Almeida Brian Wilson J Robert Beecroft Marc de Perrot Bradly Wouters Akbar Beiki-Ardakani Jan Delabie Gang Zheng Alejandro Berlin Neesha Dhani Camilla Zimmermann Hal Berman Eleftherios Diamandis Marcus Bernardini Phedias Diamandis Scientists Lori Bernstein Robert Dinniwell Laurie Ailles Mark Bernstein Susan Done Scott Bratman Andrea Bezjak James Downar Steven Chan Jean-Pierre Bissonnette Daniel Drucker Ralph DaCosta Ivan Blasutig Alexandra Easson Daniel De Carvalho Scott Boerner Saibishkumar Elantholi Kim Edelstein Jette Borg Parameswaran Benjamin Haibe-Kains Penelope Bradbury Elena Elimova Housheng Hansen He Anthony Brade Mary Elliott Michael Hoffman Donald Branch Christine Elser Jennifer Jones Savtaj Brar Jaime Escallon Marianne Koritzinsky Stephen Breen Andrew Evans Nadeem Moghal William Brien Hannaneh Faghfoury Catherine O’Brien James Brierley Ronald Feld Trevor Pugh Dale Brown Louis Fenkell Rodger Tiedemann John Bryson Peter Ferguson Gelareh Zadeh Ronald Burkes Sarah Ferguson Marcus Butler Antonio Finelli Assistant Scientist Marco Carlone Neil Fleshner Chris Marshall Charles Catton Jeremy Freeman David Cescon Anthony Fyles Affiliate Scientists Hong Chang Steven Gallinger Eric Chen William Chapman William Geddie Mary Jane Esplen Tanya Chawla Fred Gentili Anthony Joshua Christine Chen Sandeep Ghai C Anne Koch Terry Cheng Sangeet Ghai Paul Kongkham Douglas Chepeha Danny Ghazarian Jason Moffat Runjan Chetty Ralph Gilbert Michael Moran Carol Cheung Meredith Giuliani Michael Reedijk Frederick Cheung Rebecca Gladdy Paul Ritvo Charles Cho David Goldstein Leonardo Salmena John Cho Pamela Goodwin Michael Sherar Young-Bin Cho Chiara Gorrini Sachdev Sidhu James Chow Mary Gospodarowicz Suzanne Trudel Caroline Chung Rashmi Goswami Jean Wang Peter Chung Anand Govindarajan Wei Xu Tae Bong Chung David Grant Tulin Cil David Green Cancer Clinical Research Unit Blaise Clarke Paul Greig (CCRU) Sean Cleary Robert Gryfe Ayman Al Habeeb Catherine Coolens Patrick Gullane Hamideh Alasti-Hamed Timothy Craig Abha Gupta Zishan Allibhai Jennifer Croke Vikas Gupta Dominick Amato Michael Crump Sara Hafezi-Bakhtiari Pavel Crystal† Masoom Haider

32 Sarah Hales Ernie Mak David Shultz Robert Hamilton Myles Margolis E Rand Simpson Kathy Han Warren Mason Lillian Siu Anthony Hanbidge Andrew Matthew Joyce So Breffni Hannon Taymaa May Anna Spreafico Aaron Hansen J Andrea McCart Boraiah Sreeharsha Robert Heaton David McCready Srikala Sridhar Aaron Hendler Allison McGeer Teodor Stanescu David Hodgson Ian McGilvray Alexander Sun Stefan Hofer Andrea McNiven D Robert Sutherland David Hogg Tatiana Melnyk Carol Swallow Andrew Hope Cynthia Ménard Joan Sweet David Hwang Hans Messner Eva Szentgyorgyi Jonathan Irish Ozgur Mete Tony Tadic Mohammad Islam Ur Metser Ian Tannock Hyun-Jung Jang Fotios Michelis Mojgan Taremi Raymond Jang Barbara-Ann Millar Bryce Taylor Jeffrey Jaskolka Kim Miller Santhosh Thyagu Michael Jewett Naomi Miller Anne Tierens Kartik Jhaveri Michael Milosevic Ants Toi Sarah Johnson Eric Monteiro Emina Torlakovic John Kachura Chantal Morel John Trachtenberg Suzanne Kamel-Reid Carol-anne Moulton Richard Tsang Zahra Kassam Anna Marie Mulligan Hubert Tsui Edward Kassel Kieran Murphy Rajkumar Vajpeyi Ebru Kaya Rumina Musani Theodorus van der Kwast Armand Keating Rinat Nissim Monique van Prooijen Harald Keller Nancy Olivieri Auro Viswabandya Erin Kennedy Martin O’Malley Thomas Waddell Shaf Keshavjee Anne O’Neill John Waldron Korosh Khalili Brian O’Sullivan Julia Wang Tim-Rasmus Kiehl Amit Oza Richard Ward Dennis Kim Prodipto Pal Padraig Warde John Kim Sophia Pantazi David Warr Raymond Kim Demetris Patsios Robert Weersink Tae Kyoung Kim Narinder Paul Alice Wei Jennifer Knox Bayardo Perez-Ordonez Ilan Weinreb Hyang Mi Ko Andrew Pierre Woodrow Wells Hatem Krema Anca Prica Kirsten Wentlandt Monika Krzyzanowska Thomas Purdie Lawrence White Vishal Kukreti Fayez Quereshy Daniel Winer Vathany Kulasingam Graeme Quest Ian Witterick Girish Kulkarni Dheeraj Rajan Jason Wong Supriya Kulkarni A Michael Rauth Rebecca Wong Kevin Kuo Albiruni Razak Robert Wood John Kuruvilla Donna Reece Jay Wunder Stéphane Laframboise G Jolie Ringash Jiong Yan David Lam Alexandra Rink Kazuhiro Yasufuku Normand Laperriere Lorne Rotstein Karen Yee Natasha Leighl Marjan Rouzbahman Erik Yeo Wey-Liang Leong Anabel Scaranelo Bruce Youngson Daniel Létourneau Heidi Schmidt Eugene Yu Wilfred Levin Andre Schuh Toni Zhong Stéphanie Lheureux Jack Seki Alexandre Zlotta Madeline Li Stefano Serra Patricia Lindsay Patricia Shaw Jeffrey Lipton Nadine Shehata Christopher Lo Frances Shepherd Helen Mackay Liran Shlush

33 TechnaTechna InstituteInstitute

Core Leads 9 Fellows 24 Scientists 4 Graduate Students 39 Affiliated Faculty 37 Total Trainees 63 Total Researchers 50

Research Space 12,484 sq. ft. Total Staff 95

External Funding $12,492,230 Publications 279

Techna Leadership Team Director, Research Faculty, Physical Sciences Director, Techna Institute David Jaffray J Paul Santerre Director, Clinical Processes Howard Abrams Director, Commercialization Mark Taylor Director, Operations & Engineering Luke Brzozowski Executive Vice President, Science and Research* Director, Knowledge Transfer Nicole Harnett Christopher Paige Director, Research Faculty, Clinical Jonathan Irish *role filled by Bradly Wouters as of Oct 1, 2016 Researchers Design & Engineering for Health James Drake Igor Jurisica Core Lead Gabor Fichtinger Peter Rossos Joseph Cafazzo Justin Grant Affiliated Faculty Affiliated Faculty Mojgan Hodaie Brenda Gallie Emily Seto Andrew Hope Alejandro Jadad Patricia Trbovich Mohammad Islam Michael Jewett Leonard Tse Daniel Létourneau Gordon Tait Andres Lozano Christian Veillette Guided Therapeutics Claire McCann Core Leads Cynthia Ménard Nanotechnology & Jonathan Irish Kieran Murphy Radiochemistry David Jaffray Narinder Paul Core Leads Walter Kucharczyk Thomas Purdie Ur Metser Scientists Dheeraj Rajan Gang Zheng Margarete Akens Alexandra Rink Affiliated Faculty † Arash Zarrine-Afsar Michael Sharpe John Valliant Jinzi Zheng Michael Sherar Affiliated Faculty Teodor Stanescu Photonics Dionne Aleman Robert Weersink Core Lead Jean-Pierre Bissonnette Bernd Wintersperger Brian Wilson Timothy Chan Kazuhiro Yasufuku Scientist Catherine Coolens Ralph DaCosta John de Almeida Informatics & Communications Affiliated Faculty Jonathan Downar Technology I Alex Vitkin Core Leads 34 Toronto General Research Institute

Senior Scientists 58 Fellows 138 Scientists 33 Graduate Students 184 Affiliate Scientists 46 Total Trainees 322 Assistant Scientist 1 Total Appointed Researchers 138 Clinical Researchers 235 Total Researchers 373

Research Space 237,840 sq. ft. Total Staff 456

External Funding $83,018,937 Publications 1,308

Research Council Director, TGRI; Research Division Head (Acting), Experimental Therapeutics Mansoor Husain Research Division Head, Advanced Diagnostics Myron Cybulsky Research Division Head, Support, Systems & Outcomes David Urbach Clinical Program Head, Transplantation Atul Humar Clinical Program Head, Peter Munk Cardiac Centre Barry Rubin Physician-in-Chief; Clinical Program Head, Medical & Community Care Edward Cole Surgeon-in-Chief; Clinical Program Head, Surgical & Critical Care Shaf Keshavjee Chair, TGRI Appointments Committee Thomas Waddell Group Lead, Cardiovascular Douglas Lee Group Lead, Metabolism Michael Wheeler Group Lead, Respiratory & Critical Care Mingyao Liu Group Lead, Communities of Health Shabbir Alibhai Executive Director, Research Operations Lisa Alcia Vice President, UHN and Executive Lead, TGH Scott McIntaggart Executive Vice President, Science and Research* Christopher Paige *role filled by Bradly Wouters as of Oct 1, 2016 Researchers Advanced Diagnostics Mingyao Liu David Cherney Senior Scientists Kumaraswamy Nanthakumar Bryan Coburn Johane Allard York Pei Shannon Dunn Peter Backx Barry Rubin Slava Epelman Daniel Cattran James Scholey Jason Fish Myron Cybulsky Katherine Siminovitch Anthony Gramolini I George Fantus Michael Wheeler Tianru Jin Eleanor Fish Eldad Zacksenhaus Ana Konvalinka Joseph Fisher Li Zhang Bruce Perkins John Floras Scientists Heather Reich Tony Lam Moumita Barua Clinton Robbins Gary Lewis Filio (Phyllis) Billia Jonathan Rocheleau

35 Toronto General Research Institute

Paaladinesh Thavendiranathan Stephen Juvet Clinical Researchers Daniel Winer Joel Katz Susan Abbey Minna Woo Thomas Lindsay Howard Abrams Affiliate Scientists Tereza Martinu Peter Adamson Donald Branch Cheri McGowan Oyedele Adeyi Hong Chang Milica Radisic Filiberto Altomare Peter Liu Raymond Reilly Frederick Au Philip Millar Sheila Riazi Carmen Avila-Casado Anna Sawka Heather Ross Mitesh Badiwala William Stansfield Coleman Rotstein Mrinalini Balki Florence Wong Michael Sefton Meyer Balter Markus Selzner Joanne Bargman Experimental Therapeutics Morris Sherman W Scott Beattie Senior Scientists Darrell Tan Chaim Bell T Douglas Bradley Terrence Yau Lee Benson Mark Cattral Assistant Scientist Matthew Binnie Marc de Perrot Sara Santana Nunes Vasconcelos Robert Bleakney Niall Ferguson Andrea Boggild Herbert Gaisano Support, Systems & Outcomes Isaac Bogoch Atul Humar Senior Scientists Mark Bonta Mansoor Husain Shabbir Alibhai Ari Breiner Harry Janssen Anne Bassett Vera Bril Kevin Kain Claire Bombardier James Brunton Rupert Kaul Angela M Cheung Paul Bunce David Kelvin Peter Cram John Byrne Shaf Keshavjee Abdallah Daar Christopher Caldarone Lakshmi Kotra Gunther Eysenbach Douglas Cameron Michael Laflamme Alastair Flint Carl Cardella Gary Levy Allan Kaplan Jose Carvalho Ren-Ke Li Moira Kapral Charles Chan Nancy Olivieri Murray Krahn Christopher Chan Vivek Rao Douglas Lee Cecilia Chaparro Thomas Waddell Charmaine Lok Anil Chopra Sharon Walmsley Robert Nolan Michael Christian Richard Weisel Gary Rodin Hance Clarke Scientists Peter Singer Edward Cole Vijay Chauhan Donna Stewart Jack Colman Chung-Wai Chow David Urbach Patricia Colton Marcelo Cypel Scientists Richard Cooper Jordan Feld Anna Gagliardi Adrian Crawley Michael Gollob S Vanita Jassal Kenneth Croitoru Margaret Herridge Janet Raboud Sharon Cushing Keyvan Karkouti Affiliate Scientists Robert Cusimano J Andrea McCart Thomas Forbes Kasia Czarnecka-Kujawa Ian McGilvray Suzanne Fredericks Patrick Darragh M Cristina Nostro Alan Fung Satya Dash Nazia Selzner Sherry Grace Tirone David Lena Serghides Brian Hodges Diego Delgado Kazuhiro Yasufuku M Jane Irvine Allan Detsky Affiliate Scientists Adrienne Kovacs Michael Detsky Marisa Battistella Jane MacIver Eleftherios Diamandis Mamatha Bhat Gail McVey Gina Dimitropoulos Gail Darling Kathryn Nichol George Djaiani Gregory Downey Marion Olmsted Michael Domanski Anand Ghanekar Rima Styra Eugene Downar David Grant George Tomlinson Andrei Drabovich Raymond Hui Alice Wei Vladimir Dzavik Shahid Husain D Blake Woodside David Ellis David Hwang Paul Ellis

36 Eddy Fan Leslie Lilly S Lucy Roche Michael Farkouh Jessica Liu Graham Roche-Nagle Nadia Farooki Louis Wing Cheong Liu Patrik Rogalla Denice Feig Alexander Logan Peter Rossos Christopher Feindel Donna Lowe John Rutka Olavo Fernandes Kelly MacDonald Irving Salit Suranga Fernando Thomas MacMillan Gonzalo Sapisochin Jolene Fisher Christine Maheu Zion Sasson David Flamer Susanna Mak Jeffrey Schiff Steven Friedman Tony Mazzulli Leonard Schwartz Scott Fung Stuart McCluskey Joerg Schwock Shital Gandhi Michael McDonald Phillip Segal Michael Gardam Heather McDonald-Blumer Peter Seidelin Adam Gehring Micheal McInnis Rita Selby Susan George Martin McKneally Mohammad Shafiee Peter Giacobbe Robin McLeod Shane Shapera Shiphra Ginsburg Rory McQuillan Eran Shlomovitz Wayne Gold Karen McRae Naveed Siddiqui Roger Goldstein Sangeeta Mehta Michael Sidiropoulos John Granton Massimiliano Meineri Mark Silverberg Gordon Greenberg Ravi Menezes Candice Silversides Sandra Grgas Leonid Minkovich Lianne Singer Luís Guimarães Shikha Mittoo Samir Sinha Andrew Ha Ravi Mohan Anna Skorzewska Flavio Habal Matthew Morgan Peter Slinger Kate Hanneman Andrew Morris Kenneth Sniderman Louise Harris Istvan Mucsi Miranda So Laura Hawryluck Patricia Murphy Sanjeev Sockalingam Carol Heck Emily Musing Danna Spears Edward Hickey Krishnakumar Nair Coimbatore Srinivas Chia Sing Ho Gillian Nesbitt Andrew Steel Eric Horlick Gary Newton A Hillary Steinhart Susy Hota Elsie Nguyen Marshall Sussman Frances Hoy Geoffrey Nguyen Adrienne Tan Michael Hutcheon Peter Nielsen Kong Teng Tan Douglas Ing Marta Novak John Thenganatt Nasir Jaffer Erwin Oechslin Seng Thipphavong Cheryl Jaigobin Gerald O’Leary Lianne Tile Angela Jerath George Oreopoulos Kathryn Tinckam Rohan John Mark Osten Kathryn Trottier Christine Jonas-Simpson Mirek Otremba Wendy Tsang Tuula Kalliomäki Maral Ouzounian Alice Tseng Sonja Kandel Christopher Overgaard Jacob Udell Jacek Karski Andrea Page Amar Uxa Hans Katzberg Blake Papsin Glen Van Arsdell Rita Katznelson John Parker Annette Vegas Edward Keystone Jesse Pasternak Allan Vescan Jay Keystone Jacob Pendergrast Rachel Wald S Joseph Kim Todd Penner Paul Walfish John Kingdom David Pothier Marcin Wasowicz Caroline Kramer Lisa Puchalski Ritchie Cynthia Whitehead Kulamakan Mahan Kulasegaram Harry Rakowski Duminda Wijeysundera Deepali Kumar Anthony Ralph-Edwards Stephen Wolman Ayelet Kuper Marciano Reis Pui-Yuen Wong Bindee Kuriya Eberhard Renner Anna Woo Janice Kwan Ravi Retnakaran Linda Wright Megan Landes Robert Richardson Robert Wu Stephen Lapinsky Michael Robinette Paul Yip Lani Lieberman Gail Robinson Bernard Zinman

37 TorontoToronto Rehabilitation InstituteInstitute

Senior Scientists 23 Fellows 30 Scientists 22 Graduate Students 93 Affiliate Scientists 65 Total Trainees 123 Total Appointed Researchers 110 Clinical Researchers 6 Total Researchers 116

Total Staff 117 Research Space 65,378 sq. ft.

External Funding $17,551,095 Publications 445

Research Advisory Committee (RAC) Director, TRI; Chair, RAC Geoff Fernie Associate Academic Director of Research, TRI Susan Jaglal Associate Scientific Director of Research, TRI Milos Popovic Team Leaders T Douglas Bradley, Angela Colantonio, Tilak Dutta, Robin Green, Avril Mansfield, Katherine McGilton, Alex Mihailidis, Paul Oh, Milos Popovic, Catriona Steele, Yana Yunusova Sub-Committee Chairs Catherine Craven, Susan Jaglal, Katherine McGilton, Milos Popovic Business Development & Organization Effectiveness Catharine Hancharek Research Services & Operations Lois Ward Senior Vice President, UHN and Executive Lead, TR Susan Jewell Executive Vice President, Science and Research* Christopher Paige *role filled by Bradly Wouters as of Oct 1, 2016 Researchers Acquired Brain Injury & Society Scientist Brain Discovery & Recovery Senior Scientists Babak Taati Senior Scientists Mark Bayley Affiliate Scientists Robin Green Angela Colantonio Sonya Allin Affiliate Scientists Scientist Sven Dickinson Doug Richards Nora Cullen David Fleet Jennifer Steeves Affiliate Scientists Deborah Hébert Deirdre Dawson Dana Kulić Cardiorespiratory Fitness Emily Nalder Alan Mackworth Senior Scientists Mary Stergiou-Kita Goldie Nejat David Alter Pascal Poupart Sherry Grace Artificial Intelligence & Robotics Rosemary Ricciardelli Scientists for Rehabilitation Rosalie Wang Tracey Colella Senior Scientist Paul Oh Alex Mihailidis

38 Affiliate Scientists Mary Fox W Darlene Reid Jack Goodman Jesse Hoey Scientists Krista Lanctôt Andrea Iaboni Hisham Alshaer Scott Thomas Andrew Laing Azadeh Yadollahi Sunita Mathur Affiliate Scientist Communication Laura Middleton Brian Murray Senior Scientists George Mochizuki Clodagh Ryan Elizabeth Rochon Stephen Perry Yana Yunusova James Pratt Swallowing Science Scientist Karl Zabjek Senior Scientists Frank Rudzicz Catriona Steele Affiliate Scientists Neural Engineering & Affiliate Scientists Melanie Baljko Therapeutics Lisa Duizer Boaz Ben-David Senior Scientists Craig Chambers B Catharine Craven Clinical Researchers Tom Chau Milos Popovic Julia Alleyne Petros Faloutsos Scientists Anthony Burns Karen Gordon César Márquez-Chin Colleen McGillivray Julie Mendelson Kei Masani Denyse Richardson Aravind Namasivayam Kristin Musselman Harpreet Sangha Kathleen Pichora-Fuller Jose Zariffa Gaétan Tardif Frank Russo Affiliate Scientists Gurjit Singh Sandra Black Pascal van Lieshout Julio Furlan Lora Giangregorio Home, Community & Institutional Sander Hitzig Environments Pamela Houghton Senior Scientists Mary Nagai Geoff Fernie Ethne Nussbaum Andrea Furlan Linda Rapson Scientists Molly Verrier Jennifer Campos Timothy Welsh Tilak Dutta Paul Yoo Bruce Haycock Behrang Keshavarz Optimization of the Rehab System Alison Novak Senior Scientists Christine Novak Mark Bayley Affiliate Scientists Cheryl Cott Veronique Boscart Andrea Furlan Karen Gordon Susan Jaglal Dinesh Kumbhare Pia Kontos Matthew Muller Katherine McGilton Hani Naguib I Gary Naglie Donald Philip Scientists Veronica Wadey Shabbir Alibhai Nora Cullen Mobility Walter Wodchis Senior Scientists Affiliate Scientists Dina Brooks G Ross Baker Brian Maki Veronique Boscart William McIlroy† Jill Cameron W Darlene Reid Mary Fox Scientists Nancy Salbach William Gage Kathryn Sibley Avril Mansfield Kara Patterson Sleep Science Affiliate Scientists Senior Scientists Alastair Flint T Douglas Bradley

39 UHN Research Committees

Biomedical Research Pam Savage John Floras Krembil Trainee Affairs Ethics Board: Panel A Aaron Schimmer Carole Garmaise Committee Alan Barolet (Chair) Susanna Sellmann John Granton Anna Badner Sharon Braganza Theo van der Kwast Jin Huh Jason Charish Daniel Buchman Camilla Zimmerman Deepali Kumar Robert Chen Kim Cadario Paul MacPherson Jonathon Chio Derek Cathcart Cancer Clinical Research Paul Oh Leanne Da Costa Robert Cusimano Unit Management Amit Oza Aidan Dineen Seema David Committee Christopher Paige (Co- Rachel Dragas Erin Dobbelsteyn Chantale Blattler Chair) Helal Endisha James Downar Karen Chadwick Patrik Rogalla Alexandre Guet-McCreight Scott Fung Bholy Chaudhary Katie Roposa William Hutchison Peter Giacobbe Heather Cole David Urbach Igri Kolaj Andrew Ha Pamela Degendorfer (Chair) Sharon Walmsley Alex Laliberte Jane Lui Jeff Doi Amy Ma Connie Marras (Vice Chair) Marcia Flynn-Post Data Safety Monitoring Mary Pat McAndrews Heather Sampson Jasmine Grant Board Carley McPherson Samantha Sonshine Julie Gundry Mary Anne Chappell Samira Patel Carl Virtanen Sisi Jia Heather Cole (ex officio) Johanna Ponnuthurai Jean Wang Tuula Kalliomäki Kathy Han Anton Rogachov Duminda Wijeysundera Jennifer Li Krystal Internicola (ex Kairavi Shah Noe Zamel Karen Ng officio) Ahad Siddiqui Gerard Paras Haiyan Jiang Frances Skinner (Chair) Biomedical Research Nishita Parekh Girish Kulkarni Manoj Vasudeva Ethics Board: Panel B Michele Petrovic (Interim) John Kuruvilla Julie Wan Kyle Anstey Lindsay Philip Srikala Sridhar (Chair) Joan Wither Alan Barolet (Chair) Jesus Piza-Rodriguez Ruth Turner Meital Yerushalmi Ruth Anne Baron Tracey Powell Zhenbo Zhang David Barth (Vice Chair) Menaka Pulandiran Krembil Appointments David Cherney Kendra Ross Committee Oncology Research Sean Cleary Maria Schlag Elizabeth Badley Ethics Board: Panel C Natasha Danson Susanna Sellmann (Co- Peter Carlen Eitan Amir Nigil Haroon Chair) Karen Davis Jennifer Bell Magdy Hassouna Vanessa Speers James Eubanks Hal Berman Michael Hutcheon Marissa Tang Fong Andres Lozano (Chair) Anthony Brade (Vice Chair) Stephanie Kellowan Ruth Turner Valerie Wallace Daniel Buchman Charmaine Lok Tracy Wong (Interim) Donald Weaver Marcus Butler Roger McIntyre Celeste Yu R Michael Crump Ali Naraghi Krembil Clinician Stephanie DeLuca Todd Orvitz Cancer Registry and Data Investigator Robert Dinniwell John Parker Access Committee Appointments Jaime Escallon Ron Seto Niki Agelastos (Committee Committee Ronald Feld Morris Sherman Secretariat) Mary Pat McAndrews Vikas Gupta Lorisa Stein James Brierley (Chair) Y Raja Rampersaud Robert Hamilton Naomi Visanji Carol Cheung Antonio Strafella Aaron Hansen Darlene Dale (Co-Chair) Donald Weaver (Chair) Jack Holland (Chair) Cancer Clinical Alexandra Easson Leila Khoja Research Unit Executive Calven Eggert Krembil Space Belling Leung Committee David Goldstein Committee Carmen Li James Brierley David Hodgson Elizabeth Badley Manjula Maganti Pamela Degendorfer (Co- Monika Krzyzanowska Karen Davis Warren Mason Chair) John Kuruvilla James Eubanks (Chair) Frank Michelis Anthony Fyles Tony Panzarella Ian McDermott Albiruni Razak Krystal Internicola (ex Bayardo Perez-Ordonez Frank Vidic Katherine Renison officio) Valerie Wallace Gordon Robinson Jennifer Knox Clinical Studies Quality Donald Weaver Mohamed Shanavas Amit Oza (Chair) Committee Joan Wither Donald Short Michael Reedijk Lisa Alcia Gregory St. Pierre Patrik Rogalla Charles Chan (Co-Chair) Jenna Sykes

40 Santhosh Thyagu Rehabilitation Medicine Tom Goldthorpe TRI Junior Scientists’ Ruth Turner and Science Research Tony Goncalves Support & Mentorship Ethics Board: Panel D Alex Karabanow Committee PM Appointments Puja Ahluwalia Amy Ma Tracey Colella Committee Tania Artinian Paul MacPherson Susan Jaglal (Chair) Razq Hakem Jeffery Baine Carley MacPherson Avril Mansfield Richard Hill Carly Barbon Ian McDermott Lois Ward Norman Iscove Jennifer Boger (on leave) Peggy McGill Azadeh Yadollahi David Jaffray Anthony Burns Kathy McGilton Rama Khokha (Chair) Tracey Colella Tracy McQuire TRI Scientists’ Tak Mak Carol Fancott Badru Moloo Productivity & Mark Minden Heather Flett Lisa Murphy Promotions Committee Gilbert Privé Diana Frasca Christopher Paige Geoff Fernie Gary Rodin Igor Gontcharov Katie Roposa (Co-Chair) Susan Jaglal Robert Rottapel Susan Gorski Evelina Rutkowski Milos Popovic (Chair) Vuk Stambolic Lindsay Green-Noble Gianfranco Scipione Bradly Wouters Ann Heesters (Chair) Anita Sengar TRI Standard Operating Shadi Katirai (on leave) John Shannon Procedures Committee PM Equipment Pia Kontos Alena Siarheyeva Jennifer Campos Committee Avril Mansfield Mike Voth Geoff Fernie (Co-Chair) Laurie Ailles César Márquez-Chin Lois Ward Catharine Hancharek Mitsuhiko Ikura Kei Masani Tania Yousaf Susan Jaglal Rama Khokha Nadia Meli Katherine McGilton (Co- Thomas Kislinger Ashwini Namasivayam TGRI Appointments Chair) Trevor Pugh Diane Nixon (on leave) Committee Milos Popovic Robert Rottapel Stephanie Nixon David Cherney Lois Ward Malcolm Smith Paul Oh (Vice Chair) Angela Cheung Ming-Sound Tsao Archna Patel Myron Cybulsky TRI Students’ Support & Brian Wilson (Chair) Linda Penoyer (on leave) Shannon Dunn Mentorship Committee Patrick Yau Marta Pesin Anna Gagliardi Susan Jaglal (Chair) Karen Sasaki Margaret Herridge Johanna Ponnuthurai PM Space Committee Kathryn Sibley Mansoor Husain Lois Ward Michael Hoffman Catriona Steele Christopher Paige Mitsuhiko Ikura Shauna Stokely David Urbach TRI Team Leaders’ Rama Khokha Yervant Terzian Thomas Waddell (Chair) Committee Pamela Ohashi (Chair) Daniel Vena Minna Woo T Douglas Bradley Gary Rodin Rosalie Wang Angela Colantonio Aaron Schimmer Rosalind Waxman TRI Central Patient & B Catharine Craven Nykema Wright Subject Recruitment Tilak Dutta Radionuclide Safety Lesley Wylie Committee Geoff Fernie (Chair) Committee Audrey Yap Mark Bayley Robin Green Shelley Belford B Catharine Craven (Chair) Catharine Hancharek (ex Jonathan Brotchie Research Biosafety Geoff Fernie officio) Gina Capone Committee Susan Jaglal Susan Jaglal Perry Chong Lorraine Kalia Simon Jones Avril Mansfield Mary Fountas Camille Lemieux Katherine McGilton Judy Gabrys (Co-Chair) Jeanette MacLean (ex TRI International Alex Mihailidis Mihaela Ginj offico) Scientific Advisory Paul Oh David Green Ian McDermott (ex offico) Committee Milos Popovic Norman Iscove Badru Moloo (ex offico) Martin Ferguson-Pell Catriona Steele Ian McDermott Gilbert Privé William Mann Yana Yunusova Ur Metser John Shannon (Acting Anne Martin-Matthews Jerry Plastino Chair) (Chair) TRI Team Leadership & Deborah Scollard Alain Ptito Productivity Committee Frank Tourneur (Co-Chair) Research Risk and Audit Jerker Rönnberg Geoff Fernie Li Zhang Committee John Steeves Susan Jaglal Lisa Alcia (Chair) Milos Popovic (Chair) Chip Campbell Gabriella Fischer

41 External Sponsors

Abbott Laboratories Baxter Healthcare Health Authority Grand Challenges Canada AbbVie Corporation Bayer Cardiac Care Network of Grifols Abiomed Beckman Coulter Ontario Hackensack University Acelity Beth Israel Deaconess Carestream Health Medical Center Acetylon Pharmaceuticals Medical Center Cedars-Sinai Medical Center Hamilton Health Sciences Actelion Pharmaceuticals BioCanRX Celator Pharmaceuticals Health Quality Ontario ActiveO Biocompatibles UK Celgene Health Technology Adamas Pharmaceuticals BioDiscovery Toronto Centre for Addiction and Exchange Aeglea Biotherapeutics Biogen Mental Health Heart and Stroke AGA Medical Biotronik Centre for Foundation of Canada Agensys Boehringer Ingelheim Commercialization of Heart and Stroke AGE-WELL Boston Biomedical Regenerative Medicine Foundation of Ontario Agios Pharmaceuticals Boston Medical Center Centre for Probe Hemostemix AKR Development Boston Scientific Development and Henry Ford Health System Alexion Pharmaceuticals Bracco Diagnostics Commercialization Horizon Pharma Alfred Health Brain Canada Centre hospitalier de Hospira Alpha Cancer Technologies Bristol-Myers Squibb l’Université de Montréal HSF Canadian Partnership Alzheimer Society of British Columbia Cancer Cervical Spine Research for Stroke Recovery Canada Agency Society Icahn School of Medicine at Alzheimer’s Association Canada Foundation for Children’s Hospital of Mount Sinai Ambit Biosciences Innovation Philadelphia Imagistx American Association for Canada Research Chairs Chimerix INC Research Hand Surgery Program CIHR Canadian HIV Trials Insmed American Association for Canadian Agency for Drugs Network Institut de recherche Thoracic Surgery and Technologies in Cincinnati Children’s Robert-Sauvé en santé et American Association of Health Hospital Medical Center en sécurité du travail Neurological Surgeons Canadian Anesthesiologists’ Clinique La Prairie Institut universitaire American Brain Foundation Society Columbia University de cardiologie et de American College of Canadian Association of Conquer Paralysis Now pneumologie de Québec Rheumatology Gastroenterology Cook Group Institute for Clinical American Medical Systems Canadian Association of Craig H. Neilsen Foundation Evaluative Sciences Europe BV Psychosocial Oncology CSL Behring Integrative Biology of Breast American Society for Bone Canadian Association of CTI BioPharma Cancer Research Centre and Mineral Research Radiation Oncology Cystic Fibrosis Canada Intercept Pharmaceuticals American Society of Clinical Canadian Blood and Marrow Daiichi Sankyo International Parkinson and Oncology Transplant Group Dartmouth College Movement Disorder American Society of Canadian Blood Services Duke University Society Hematology Canadian Breast Cancer Dystonia Medical Research Israel Cancer Research American Society of Foundation Foundation Fund Transplant Surgeons Canadian Cancer Society Edwards Lifesciences J.P. Bickell Foundation American Thoracic Society Research Institute Eisai Jaeb Center for Health American Urological Canadian Diabetes Eli Lilly Canada Research Association Association Epilepsy Canada Janssen Amgen Canadian Foundation for European Organisation for Jewish General Hospital Anesthesia Patient Safety AIDS Research Research and Treatment John Wiley and Sons Foundation Canadian Frailty Network of Cancer Johns Hopkins University Anthera Pharmaceuticals Canadian Heart Research Exelixis JSS Medical Research AOSpine Centre Ferring Pharmaceuticals Juvenile Diabetes Research APOCARE Pharma Canadian Institutes of Foundation Fighting Foundation Canada Aptose Biosciences Health Research Blindness Karyopharm Therapeutics Aragon Pharmaceuticals Canadian Liver Foundation Fred Hutchinson Cancer Kiadis Pharma Arbutus Biopharma Canadian National Transplant Research Center Kidney Cancer Canada Arthritis Research Research Program GBS/CIDP Foundation Krembil Foundation Foundation Canadian Occupational International Kyowa Hakko Kirin Associated Medical Therapy Foundation GE Canada Lahey Clinic Foundation Services Canadian Partnership GE Healthcare Lawson Health Research Association of University Against Cancer Genentech Institute Radiologists Canadian Psychological Generex Biotechnology Leukemia and Lymphoma Astellas Pharma Association Genome Canada Society Astex Pharmaceuticals Canadian Society of Genzyme Canada Leukemia and Lymphoma AstraZeneca Hospital Pharmacists Gilead Sciences Society of Canada Avanir Pharmaceuticals Cancer Care Ontario Glaucoma Research Society Leukemia Research Barbara Ann Karmanos Cancer Research Institute of Canada Foundation of Canada Cancer Institute Cancer Research Society GlaxoSmithKline Li Ka Shing Foundation Bavarian Nordic Capital Health - Nova Scotia Global Affairs Canada Llewellyn Market Research

42 London Health Sciences Novartis Quintiles The Princess Margaret Centre Novo Nordisk Radiological Society of Cancer Foundation Lumena Pharmaceuticals NRG Oncology North America The W. Garfield Weston Lundbeck Canada NSABP Foundation RaySearch Foundation Lung Biotechnology Olympus Research Institute of the Theralase Lupus Ontario Ontario Brain Institute McGill University Health Thoratec Lutonix Ontario Centres of Centre Thornhill Research MaRS Innovation Excellence Rick Hansen Foundation Thrasos Innovation Massachusetts General Ontario Clinical Oncology Rick Hansen Institute Threshold Pharmaceuticals Hospital Group Roche Tokai Pharmaceuticals Mathematics of Information Ontario HIV Treatment Roche Organ Toronto Central Local Health Technology And Complex Network Transplantation Research Integration Network Systems Ontario Institute for Cancer Foundation Toronto Dementia Research Matrizyme Pharma Research Royal College of Physicians Alliance Mayo Clinic Ontario Institute for and Surgeons of Canada Toronto General & Western McGill University Regenerative Medicine Rutgers University Hospital Foundation McGuire Research Institute Ontario Lung Association Saint Elizabeth Health Care Toronto Rehab Foundation McMaster University Ontario Mental Health Samuel Waxman Cancer Toshiba Medical Systems Medical Council of Canada Foundation Research Foundation Trillium Therapeutics MedImmune Ontario Neurotrauma Sandra Rotman Centre Triphase Accelerator Medivation Foundation Sanofi Corporation Medpace Ontario Telemedicine Schering-Plough TVA Medical Medtronic Network Seattle Children’s Hospital UCB Medtronic Bakken Research Onyx Pharmaceuticals Sequana Medical United States Department Center Ophthotech Shire of Defense Merck Osteoporosis Canada SickKids University of Alberta Merz Pharma Otsuka Canada Sideris Pharmaceuticals University of British Mesothelioma Applied Pharmaceutical Sigma Theta Tau Columbia Research Foundation Ottawa Health Research International University of Calgary MicroVention Institute Simon Fraser University University of California, Los Millennium Pharmaceuticals Oxford Immunotec Society for Vascular Surgery Angeles Ministry of Health and Long- Pan American Health Foundation University of California, San Term Care Organization Society of American Francisco Ministry of Labour Pancreatic Cancer Canada Gastrointestinal and University of Chicago Ministry of Research, Foundation Endoscopic Surgeons University of Colorado Innovation and Science Paralyzed Veterans of Society of Anesthesia and University of Florida Mitacs America Education Sleep Medicine University of Iowa Montreal Heart Institute Foundation Spencer Foundation University of Medicine and Morton Cure Paralysis Fund Parexel St. Joseph’s Health Centre Dentistry of New Jersey Mount Sinai Hospital Parkinson Canada St. Jude Medical University of Michigan Multiple Myeloma Research Parkinson’s Disease St. Michael’s Hospital University of Ottawa Consortium Foundation Stanford University University of Ottawa Heart Multiple Myeloma Research Partners HealthCare State University of New York Institute Foundation Pathology Associates Stem Cell Network University of Pennsylvania Multiple Sclerosis Society of Pfizer StemCells University of Regina Canada Pharmaceutical Product Sunnybrook Health University of Rochester Muscular Dystrophy Canada Development Sciences Centre University of Saskatchewan National Institutes of Health Pharmacyclics Susan G. Komen University of Texas National Multiple Sclerosis Philips Takara Bio University of Toronto Society Physicians’ Services TauRx Therapeutics University of Washington National Parkinson Incorporated Foundation Ted Rogers Centre for Heart University of Waterloo Foundation Physiotherapy Foundation of Research University of Zurich Natural Sciences and Canada Terry Fox Research Institute Vancouver Coastal Health Engineering Research Polynoma Terumo Cardiovascular Research Institute Council of Canada Population Health Research Systems VistaGen Therapeutics Nektar Therapeutics Institute Tesaro Western University Nestec PRA Health Sciences Thalassemia Foundation of Wings for Life Networks of Centres of Prometic Life Sciences Canada Women’s College Hospital Excellence of Canada Prostate Cancer Canada The Arthritis Society YM BioSciences NeuroDevNet ProteoMediX The Kidney Foundation of York University New England Research Proteomic Methods Canada Institutes Prothena The MAYDAY Fund New York University Public Health Ontario The Michael J. Fox Northern Biologics Qiagen Foundation for Northwestern University Queen’s University Parkinson’s Research

43 Financials 2015/2016

Total Core Research Funding $72,719,135

UHN Foundations $36,327,810

Other (including ancillary revenues) $16,690,082

Grant Funding (indirect costs) $12,187,250

Ministry of Health and Long-Term Care $3,379,700

Rental Income $2,239,151

Investment Income $1,895,142

44 Total External Project Funding $308,324,800

Other $3,213,461

Corporate Contracts $4,362,671

Career/ Traineeship Awards $9,669,471

Infrastructure/ Maintenance Awards $23,866,880

Clinical Studies $45,215,193

UHN Foundations $100,273,108

Operating Grants $121,724,016

45 International Research Advisory Board

Samuel Weiss, PhD (Chair) Professor, Departments of Cell Biology & Anatomy and Physiology & Pharmacology, University of Calgary; Inaugural Director of the Hotchkiss Brain Institute

Philip E Branton, OC, PhD, FRSC Gilman Cheney Professor, Departments of Biochemistry and Oncology and the Goodman Cancer Centre, McGill University

Thomas Rockwell Mackie, PhD Professor Emeritus, Medical Physics and Human Oncology, University of Wisconsin; Director, Medical Devices Focus Area, Morgridge Institute for Research

Lynne Warner Stevenson, MD Director, Cardiomyopathy and Heart Failure Program, Brigham and Women’s Hospital; Professor, Harvard Medical School

John E Wennberg, MD, MPH Active Professor Emeritus of Community & Family Medicine, Peggy Y Thomson Professor Emeritus in Evaluative Clinical Sciences and Director Emeritus and Founder, The Dartmouth Institute for Health Policy & Clinical Practice

Research Committee Board of Trustees

Independent Trustees (Voting) Robert Krembil (Chair), John Mulvihill, Barbara Stymiest, Ken Rotman

Ex-officio Trustees (Voting) Peter Pisters, Joy Richards, Kathryn Nichol

Others (Voting) Marc Milgrom, Stephen Bear, Mark Krembil, Lawrence Pentland, Linda Mezon

Ex-officio Non-Trustees (Non-voting) Christopher Paige, Justine Jackson, John Granton

Disclaimers Publications, Personnel, Research Committees: Publication data provided by UHN Research Program Planning & Analysis. Leadership data provided by UHN institute Business Managers. Data accurate as of September 1, 2016. Some figures may be rounded and/or may include data not represented in institute data. Publications jointly authored by investigators at multiple UHN institutes are counted only once in the UHN Research total. Researchers with more than one affiliation within an institute, or between institutes, are only included once in the total count. Metrics for each institute were calculated by considering data on all Researchers, which include CCRU or Clinical Researchers as applicable. Please note that Clinical Researchers and CCRU investigators are not formally appointed at the research institutes and are therefore not subject to the research institutes’ scientific and performance reviews. Clinical Researchers are defined as UHN staff who are listed as co-author on at least one publication in the 2015 calendar year and/or held research funding over the 2015/16 fiscal year. †Drs. Crystal (page 32), Sharpe (page 34) and McIlroy (page 39) passed away in 2016.

Trainees: Institute trainee counts are accurate as of August 1, 2016 and were provided by UHN’s Office of Research Trainees. They reflect only those trainees supervised by researchers with a primary appointment at the institute and who spent more than 50% of their time at UHN.

Space: Data provided by UHN Research Facilities Planning & Safety and based on space audited by September 30, 2016 across UHN sites. Core facilities and Research Solutions and Services spaces are not included in institute space totals.

Financial Data: All figures represent the fiscal year ending March 31, 2016, and include the Krembil, PM Cancer Centre, TGRI, TRI, Techna and Research Operations. Figures have been provided by UHN Research Financial Services. Total funding includes External and Core Funding amounts and is listed within the UHN Research Snapshot on the inside front cover.

Production Credits: This report is published by the Office of the Executive Vice President, Science and Research, UHN. Graphic design, writing and production by UHN’s Strategic Research Initiatives Development Team.

46 AboutAbout the covercover:: InIn businessbusiness culture, silo mentality is an attitude that occurs when departments or groupsgroups within an organizationorganization work in isolation and do not share informationinformation with other individuals in the same organization. The cover image is a graphic representation of silos being broken down in a research hospital to enable sharing of knowledge between different disciplines, departments, fields and health professions—a key requirement for translating research discoveries into clinical practice. The cover photograph features the Canada Malting Silos located on the Toronto waterfront, which were built in 1928.

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