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Rabbit Anti-GP210/FITC Conjugated antibody

SL13495R-FITC

Product Name: Anti-GP210/FITC Chinese Name: FITC标记的核膜glycoprotein210抗体 FLJ22389; GP 210; KIAA0906; pore membrane protein POM 210; membrane glycoprotein 210; Nuclear pore protein gp210; Alias: 210; Nucleoporin 210kDa; Nucleoporin Nup210; Nucleoporin210; NUP 210; NUP210; PO210_HUMAN; POM 210; POM210; Pore membrane protein of 210 kDa. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat, ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 203kDa Cellular localization: The cell membrane Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human GP210 Lsotype: IgGwww.sunlongbiotech.com Purification: affinity purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. background: The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than Product Detail: 100 different subunits. Many of the subunits belong to a family called (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). gp210, also known as Nup210 (nucleoporin 210kDa) or POM210, is a 1,887 amino acid single-pass type I membrane protein that localizes to both the and to the nucleus, specifically within the NPC. Expressed ubiquitously with highest expression in pancreas, testis, lung, ovary and liver, gp210 functions as a nucleoporin that is capable of dimerization and is essential for the assembly, fusion and structural integrity of the NPC. gp210 exists as multiple alternatively spliced isoforms and is subject to post-translational .

Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

Subunit: Forms dimers and possibly higher-order oligomers (By similarity).

Subcellular Location: Nucleus; nuclear pore complex. Nucleus membrane. Endoplasmic reticulum membrane.

Tissue Specificity: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.

Post-translational modifications: N-glycosylated, but not all potential glycosylation sites may be used. Contains high- mannose type oligosaccharides. Phosphorylated at Ser-1881 in specifically; not phosphorylated in interphase.

Similarity: Belongs to the NUP210 family.

Database links: UniProtKB/Swiss-Prot:www.sunlongbiotech.com Q8TEM1.3

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.