bioRxiv preprint doi: https://doi.org/10.1101/2021.07.22.453347; this version posted July 23, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 Conserved exchange of paralog proteins during neuronal 2 differentiation 3 4 Domenico Di Fraia1, Mihaela Anitei1, Marie-Therese Mackmull*2, Luca Parca*3, Laura 5 Behrendt1, Amparo Andres-Pons4, Darren Gilmour5, Manuela Helmer Citterich3, Christoph 6 Kaether1, Martin Beck6 and Alessandro Ori1# 7 8 Affiliations 9 1 - Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) Beutenbergstraße 1107745 Jena, Germany 10 2 - ETH Zurich Institute of Molecular Systems Biology Otto-Stern-Weg 3, 8093 Zürich, Switzerland 11 3 - Department of Biology, University of Tor Vergata, Rome, Italy 12 4 - European Molecular Biology Laboratory - EMBL, Meyerhofstraße 1, 69117, Heidelberg, Germany 13 5 - University of Zurich, Department of Molecular Life Sciences, Rämistrasse 71 CH-8006 Zürich, Switzerland 14 6 - Max Planck Institute of Biophysics, department of Molecular Sociology, Max-von-Laue-Straße 3, 60438 Frankfurt am Main 15 16 * contributed equally # 17 correspondence to
[email protected] 18 19 20 21 22 Abstract 23 Gene duplication enables the emergence of new functions by lowering the general 24 evolutionary pressure. Previous studies have highlighted the role of specific paralog genes 25 during cell differentiation, e.g., in chromatin remodeling complexes. It remains unexplored 26 whether similar mechanisms extend to other biological functions and whether the regulation 27 of paralog genes is conserved across species.