Facts About Bipolar II Disorder
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Is Your Depressed Patient Bipolar?
J Am Board Fam Pract: first published as 10.3122/jabfm.18.4.271 on 29 June 2005. Downloaded from EVIDENCE-BASED CLINICAL MEDICINE Is Your Depressed Patient Bipolar? Neil S. Kaye, MD, DFAPA Accurate diagnosis of mood disorders is critical for treatment to be effective. Distinguishing between major depression and bipolar disorders, especially the depressed phase of a bipolar disorder, is essen- tial, because they differ substantially in their genetics, clinical course, outcomes, prognosis, and treat- ment. In current practice, bipolar disorders, especially bipolar II disorder, are underdiagnosed. Misdi- agnosing bipolar disorders deprives patients of timely and potentially lifesaving treatment, particularly considering the development of newer and possibly more effective medications for both depressive fea- tures and the maintenance treatment (prevention of recurrence/relapse). This article focuses specifi- cally on how to recognize the identifying features suggestive of a bipolar disorder in patients who present with depressive symptoms or who have previously been diagnosed with major depression or dysthymia. This task is not especially time-consuming, and the interested primary care or family physi- cian can easily perform this assessment. Tools to assist the physician in daily practice with the evalua- tion and recognition of bipolar disorders and bipolar depression are presented and discussed. (J Am Board Fam Pract 2005;18:271–81.) Studies have demonstrated that a large proportion orders than in major depression, and the psychiat- of patients in primary care settings have both med- ric treatments of the 2 disorders are distinctly dif- ical and psychiatric diagnoses and require dual ferent.3–5 Whereas antidepressants are the treatment.1 It is thus the responsibility of the pri- treatment of choice for major depression, current mary care physician, in many instances, to correctly guidelines recommend that antidepressants not be diagnose mental illnesses and to treat or make ap- used in the absence of mood stabilizers in patients propriate referrals. -
Types of Bipolar Disorder Toms Are Evident
MOOD DISORDERS ASSOCIATION OF BRITISH COLUmbIA T Y P E S O F b i p o l a r d i s o r d e r Bipolar disorder is a class of mood disorders that is marked by dramatic changes in mood, energy and behaviour. The key characteristic is that people with bipolar disorder alternate be- tween episodes of mania (extreme elevated mood) and depression (extreme sadness). These episodes can last from hours to months. The mood distur- bances are severe enough to cause marked impairment in the person’s func- tioning. The experience of mania is not pleasant and can be very frightening to The Diagnotistic Statisti- the person. It can lead to impulsive behaviour that has serious consequences cal Manual (DSM- IV-TR) is a for the person and their family. A depressive episode makes it difficult or -im manual used by doctors to possible for a person to function in their daily life. determine the specific type of bipolar disorder. People with bipolar disorder vary in how often they experience an episode of either mania or depression. Mood changes with bipolar disorder typically occur gradually. For some individuals there may be periods of wellness between the different mood episodes. Some people may also experience multiple episodes within a 12 month period, a week, or even a single day (referred to as “rapid cycling”). The severity of the mood can also range from mild to severe. Establishing the particular type of bipolar disorder can greatly aid in determin- ing the best type of treatment to manage the symptoms. -
Pharmacogenomic Characterization in Bipolar Spectrum Disorders
pharmaceutics Review Pharmacogenomic Characterization in Bipolar Spectrum Disorders Stefano Fortinguerra 1,2 , Vincenzo Sorrenti 1,2,3 , Pietro Giusti 2, Morena Zusso 2 and Alessandro Buriani 1,2,* 1 Maria Paola Belloni Center for Personalized Medicine, Data Medica Group (Synlab Limited), 35131 Padova, Italy; [email protected] (S.F.); [email protected] (V.S.) 2 Department of Pharmaceutical & Pharmacological Sciences, University of Padova, 35131 Padova, Italy; [email protected] (P.G.); [email protected] (M.Z.) 3 Bendessere™ Study Center, Solgar Italia Multinutrient S.p.A., 35131 Padova, Italy * Correspondence: [email protected] Received: 25 November 2019; Accepted: 19 December 2019; Published: 21 December 2019 Abstract: The holistic approach of personalized medicine, merging clinical and molecular characteristics to tailor the diagnostic and therapeutic path to each individual, is steadily spreading in clinical practice. Psychiatric disorders represent one of the most difficult diagnostic challenges, given their frequent mixed nature and intrinsic variability, as in bipolar disorders and depression. Patients misdiagnosed as depressed are often initially prescribed serotonergic antidepressants, a treatment that can exacerbate a previously unrecognized bipolar condition. Thanks to the use of the patient’s genomic profile, it is possible to recognize such risk and at the same time characterize specific genetic assets specifically associated with bipolar spectrum disorder, as well as with the individual response to the various therapeutic options. This provides the basis for molecular diagnosis and the definition of pharmacogenomic profiles, thus guiding therapeutic choices and allowing a safer and more effective use of psychotropic drugs. Here, we report the pharmacogenomics state of the art in bipolar disorders and suggest an algorithm for therapeutic regimen choice. -
The Implications of Hypersomnia in the Context of Major Depression: Results from a Large, International, Observational Study
ARTICLE IN PRESS JID: NEUPSY [m6+; March 2, 2019;10:45 ] European Neuropsychopharmacology (2019) 000, 1–11 www.elsevier.com/locate/euroneuro The implications of hypersomnia in the context of major depression: Results from a large, international, observational study a a, b c a A. Murru , G. Guiso , M. Barbuti , G. Anmella , a, d ,e a ,f , g g h N. Verdolini , L. Samalin , J.M. Azorin , J. Jules Angst , i j k a, l C.L. Bowden , S. Mosolov , A.H. Young , D. Popovic , m c a, ∗ a M. Valdes , G. Perugi , E. Vieta , I. Pacchiarotti , For the BRIDGE-II-Mix Study Group a Barcelona Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain b Clinica Psichiatrica, Dipartimento di Igiene e Sanità, Università di Cagliari, Italy c Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Edificio Ellisse, 8 Piano, Sant’Andrea delle Fratte, 06132, Perugia, Italy d FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Catalonia, Spain e Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy f CHU Clermont-Ferrand, Department of Psychiatry, University of Auvergne, Clermont-Ferrand, France g Fondation FondaMental, Hôpital Albert Chenevier, Pôle de Psychiatrie, Créteil, France h Department of Psychiatry, Psychotherapy and Psychosomatics, -
Specificity of Psychosis, Mania and Major Depression in A
Molecular Psychiatry (2014) 19, 209–213 & 2014 Macmillan Publishers Limited All rights reserved 1359-4184/14 www.nature.com/mp ORIGINAL ARTICLE Specificity of psychosis, mania and major depression in a contemporary family study CL Vandeleur1, KR Merikangas2, M-PF Strippoli1, E Castelao1 and M Preisig1 There has been increasing attention to the subgroups of mood disorders and their boundaries with other mental disorders, particularly psychoses. The goals of the present paper were (1) to assess the familial aggregation and co-aggregation patterns of the full spectrum of mood disorders (that is, bipolar, schizoaffective (SAF), major depression) based on contemporary diagnostic criteria; and (2) to evaluate the familial specificity of the major subgroups of mood disorders, including psychotic, manic and major depressive episodes (MDEs). The sample included 293 patients with a lifetime diagnosis of SAF disorder, bipolar disorder and major depressive disorder (MDD), 110 orthopedic controls, and 1734 adult first-degree relatives. The diagnostic assignment was based on all available information, including direct diagnostic interviews, family history reports and medical records. Our findings revealed specificity of the familial aggregation of psychosis (odds ratio (OR) ¼ 2.9, confidence interval (CI): 1.1–7.7), mania (OR ¼ 6.4, CI: 2.2–18.7) and MDEs (OR ¼ 2.0, CI: 1.5–2.7) but not hypomania (OR ¼ 1.3, CI: 0.5–3.6). There was no evidence for cross-transmission of mania and MDEs (OR ¼ .7, CI:.5–1.1), psychosis and mania (OR ¼ 1.0, CI:.4–2.7) or psychosis and MDEs (OR ¼ 1.0, CI:.7–1.4). -
Bordering on the Bipolar: a Review of Criteria for ICD-11 and DSM-5 Persistent Mood Disorders Jason Luty
BJPsych Advances (2020), vol. 26, 50–57 doi: 10.1192/bja.2019.54 ARTICLE Bordering on the bipolar: a review of criteria for ICD-11 and DSM-5 persistent mood disorders Jason Luty Jason Luty, MB, ChB, PhD, SUMMARY MRCPsych, is a consultant in addic- Persistent low mood with lack of enjoyment (‘anhe- tions, liaison and general psychiatry The principal manuals for psychiatric diagnosis donia’) is common and often hard to treat in psychi- in south-east England. He trained at have recently been updated (ICD-11 was released atric practice. Recent changes in the two major the Maudsley Hospital, London, and in June 2018 and DSM-5 was published in 2013). spent 8 years as a consultant in diagnostic classification systems – ICD-11 released A common diagnostic quandary is the classification addictions with the South Essex in June 2018 (World Health Organization 2018) Partnership NHS Trust. He has a PhD of people with chronic low mood, especially those in pharmacology, following a study of with repeated self-harm (‘emotionally unstable’ or and DSM-5 (American Psychiatric Association the molecular mechanisms of recep- ‘borderline’ personality disorder). There has been 2013) – make the time apposite to review the diag- tor desensitisation and tolerance, and a great interest in use of type II bipolar affective dis- nostic categories relevant to persistent mood has published in the addictions field. order (‘bipolar II disorder’) as a less pejorative diag- disorders. Correspondence Dr Jason Luty, nostic alternative to ‘personality disorder’,despite fi Consultant Psychiatrist, Athona There is signi cant diagnostic overlap with emo- Recruitment Ltd, 1st Floor, Juniper the radically different treatment options for these tionally unstable/borderline personality disorder, House, Warley Hill Business Park, disorders. -
Guidance on the Use of Mood Stabilizers for the Treatment of Bipolar Affective Disorder Version 2
Guidance on the use of mood stabilizers for the treatment of bipolar affective disorder Version 2 RATIFYING COMMITTEE DRUGS AND THERAPEUTICS GROUP DATE RATIFIED July 2015 REPLACES Version 1 dated July 2013 NEXT REVIEW DATE July 2017 POLICY AUTHORS Jules Haste, Lead Pharmacist, Brighton and Hove Members of the Pharmacy Team (contributors are listed overleaf) If you require this document in an alternative format, i.e. easy read, large text, audio or Braille please contact the pharmacy team on 01243 623349 Page 1 of 49 Contributors Jed Hewitt, Chief Pharmacist - Governance & Professional Practice James Atkinson, Pharmacist Team Leader Mental Health and Community Services Miguel Gomez, Lead Pharmacist, Worthing. Hilary Garforth, Lead Pharmacist, Chichester. Pauline Daw, Lead Pharmacist (CRHTs & AOT), East Sussex. Iftekhar Khan, Lead Pharmacist (S&F Service), East Sussex. Graham Brown, Lead Pharmacist CAMHS & EIS. Gus Fernandez, Specialist Pharmacist MI and MH Lisa Stanton, Specialist Pharmacist Early Intervention Services & Learning Disabilities. Nana Tomova, Specialist Pharmacist, Crawley. Page 2 of 49 Section Title Page Number Introduction and Key Points 4 1. General principles in the treatment of acute mania 6 2. General principles in the treatment of bipolar depression 8 3. General principles in long term treatment 10 4. Rapid cycling 13 5. Physical health 13 6. Treatment in special situations 6.1 Pregnancy 15 6.2 Breast-feeding 17 6.3 Older adults 19 6.4 Children and adolescents 22 6.5 Learning disabilities 29 6.6 Cardiac dysfunction 30 6.7 Renal dysfunction 34 6.8 Hepatic dysfunction 37 6.9 Epilepsy 41 7. The risk of switching to mania with antidepressants 43 8. -
Chapter 7 Mood Disorders
An Overview of Mood Disorders • Gross Deviations in Mood • 2 Fundamental states: Depression & Mania Chapter 7 • Depression: “The Low” – Major Depressive Episode •The most commonly diagnosed & most severe Mood Disorders depression •Depressed (or in children, irritable) mood state that lasts at least 2 weeks –Cognitive symptoms •Feelings of worthlessness or inappropriate guilt •Diminished ability to concentrate or indecisiveness – Dysthymic Disorder –Disturbed physical functions (vegetative •Similar symptoms to Major Depressive Episode, symptoms) (central to the disorder) but milder •Insomnia or hypersomnia nearly every day –Also fewer symptoms: need only 2 of the •Significant weight loss or gain or change in symptoms, as opposed to 5 in Major Depressive appetite Episode •Fatigue or loss of energy nearly every day •A persistently depressed (or, in children & •Psychomotor agitation or retardation adolescents, irritable) mood that continues for at –Nearly always accompanied by markedly least 2 years diminished interest or ability to experience pleasure –During those 2 years, the individual has never been (anhedonia) from life without the symptoms for more than 2 months at a • Average duration if untreated: 9 months time •Most people with Dysthymia eventually experience a major depressive episode • Mania: “The High” –Abnormally exaggerated elation, joy, or euphoria OR irritability (common toward the –Behavioral symptoms end of the episode) lasting at least 1 week •More talkative / pressured speech –Cognitive symptoms •Psychomotor agitation -
What Is Bipolar Disorder?
Bipolar Disorder Fact Sheet For more information about bipolar or other mental health disorders, call 513-563-HOPE or visit our website at www.lindnercenterofhope.com. What Is Bipolar Disorder? What does your mood Each year, nearly 6 million adults (or approximately 5% of the population) in the U.S. are affected by bipolar disorder, according to the Depression and Bipolar Support say about you? Alliance. While the condition is treatable, unfortunately bipolar disorder is frequently misdiagnosed and may be present an average of 10 years before it is correctly identified. Go to My Mood Monitor™, a three minute assessment Bipolar disorder (also known as bipolar depression or manic depression) is identified for anxiety, depression, PTSD by extreme shifts in mood, energy, and functioning that can be subtle or dramatic. The characteristics can vary greatly among individuals and even throughout the and bipolar disorder, at course of one individual’s life. www.mymoodmonitor.com to see if you may need a Bipolar disorder is usually a life-long condition that begins in adolescence or early professional evaluation. adulthood with recurring episodes of mania (highs) and depression (lows) that can continue for days, months or even years. My Mood Monitor™ Copyright © 2002-2010 by M3 Information™ Phases of Bipolar Disorder • Mania is the activated phase of bipolar disorder and is characterized by extreme moods, increased or impulsive mental and physical activities, and risk taking. • Hypomania describes a mild-to-moderate level of mania. Because it may feel good to the individual experiencing it, this condition can be difficult for someone with bipolar illness to recognize as a concern. -
Life with Bipolar Fact Sheet.Pdf
Being so scared Having so Trying to You do not Exhilarating. You you’remisunderstood paralyzed much energy catch up to want the finally feel like that you stress your own high of the you’re normal, out your mind mind mania to until the anger and your body end; then sets in An amazing after the feeling that high of the leads to feeling Things are mania is horrible going You have no over, the Difficult to tell if great and inhibitions, and lows set in you can trust your it’s scary consequences and reality own perception because don’t apply to becomes a of reality You feel you know what you do problem everything at it will not once and then stay that you are numb way to the world Being on a see-saw Flipping a The of human emotion switch in future your mind “Normal” quickly people are goes Mania is speed. from annoying You must start and Being constantly in bright because finish everything activities that take up to you’ll never Productive, now—you can’t time with hardly any carefree, bleak have that stop moving results or satisfation and then stability exhausting Busy brain, When the mania busy Unending back burns out, you’ve senses, and forth with got nothing left Frightening to be so out of busy libido yourself in you control and off-balance Share what life with bipolar disorder feels like for you in words, images or video by tagging your social media posts with #mentalillnessfeelslike. Posts will be displayed at mentalhealthamerica.net/feelslike where you can also submit anonymously if you choose. -
Major Depressive Episode
Molina Healthcare Coding Education Major Depressive Episode Documentation Examples: Initial Diagnosis: 65 year old Latina presenting with new onset depressive symptoms for past 2 months including daily depressed mood, loss of energy and inability to concentrate. PHQ9 score of 12 (moderate depression). Assessment: Patent is newly diagnosed with major depression, single episode, moderate; needing medical and cognitive therapy Accurately diagnosing Major Depression requires distinguishing between a single depressive episode Plan: Start Citalopram 20 mg and refer for psychotherapy and recurrent depression. Hence, it is necessary to ICD-10 Code: F32.1 Major Depressive Disorder, single episode, moderate identify and document the manifestations of the disease burden. Another key consideration is noting OR the term “chronic” can apply to both recurrent and Initial Diagnosis: single depressive episodes. A single or first time event should be coded as F32.0-F32.9 (severity 73 year old female with many known episodes of Major specification required) and any patient who has Depression now complaining of worsening symptoms experienced subsequent episodes should be coded as including increased loss of interest in activities, hypersomnia, increased tearfulness and sadness. Denies F33.9. thoughts of self-harm ICD-10: F32.0-F32.5 Major Depressive Disorder, Assessment: Patient diagnosed with Major Depression, recurrent, single episode, specifier required (e.g., mild; unspecified; currently symptoms not controlled moderate; severe with or without psychotic Plan: Increase SSRI dosage and close follow- up recommended symptoms; in partial or full remission) ICD-10 Code: F33.9, Major Depressive Disorder, OR recurrent, unspecified ICD-10: F33.9 Major Depressive Disorder, recurrent, unspecified The Patient Health Questionnaire-9 (PHQ-9) is a multipurpose instrument for screening, diagnosing, monitoring and measuring the severity of depression. -
Depression Treatment Guide DSM V Criteria for Major Depressive Disorders
MindsMatter Ohio Psychotropic Medication Quality Improvement Collaborative Depression Treatment Guide DSM V Criteria for Major Depressive Disorders A. Five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Note: Do not include symptoms that are clearly attributable to another medical condition. 1) Depressed mood most of the day, nearly every day, as 5) Psychomotor agitation or retardation nearly every day indicated by either subjec tive report (e.g., feels sad, empty, (observable by others, not merely subjective feelings of hopeless) or observation made by others (e.g., appears restlessness or being slowed down). tearful). (Note: In children and adolescents, can be irritable 6) Fatigue or loss of energy nearly every day. mood.) 7) Feelings of worthlessness or excessive or inappropriate 2) Markedly diminished interest or pleasure in all, or almost all, guilt (which may be delu sional) nearly every day (not activities most of the day, nearly every day (as indicated by merely self-reproach or guilt about being sick). either subjective account or observation). 8) Diminished ability to think or concentrate, or 3) Significant weight loss when not dieting or weight gain indecisiveness, nearly every day (ei ther by subjective (e.g., a change of more than 5% of body weight in a account or as observed by others). month}, or decrease or increase in appetite nearly every day. (Note: In children, consider failure to make expected 9) Recurrent thoughts of death (not just fear of dying), weight gain.) recurrent suicidal ideation with out a specific plan, or a suicide attempt or a specific plan for committing suicide.