The Xiii International Congress of Toxicology

PRO GRAM The XIII BOOK International Congress WELCOME ADDRESS 1 of Toxicology

THE XIII INTERNATIONAL CONGRESS OF In conjunction with The 2nd International Conference on TOXICOLOGY Environmental OMICS

Translational Toxicology: From Basic Science to Clinical and Environmental Outcomes

JUNE 30 - JULY 4, 2013 COEX, SEOUL, KOREA

Hosted by

The Korean Society of Toxicology International Union International Conference Korean Environmental Mutagen Socity of Toxicology on Environmental OMICS The XIII 10 PROGRAM AT A GLANCE International Congress of Toxicology

JUNE 30 (SUN)

Time Lobby Hall B Auditorium GBR 101 GBR 102 GBR 103 GBR 104

08:00

Registration 09:00

10:00 CE1 CE2 CE3 CE4 Application of Statistical Modeling Risk Assessment: An Integrated OMICS Biomarkers for and Data Analysis for Principles, Application Approach & Predictive Toxicology Toxicological and and Future Nanoinformatics for Clinical Studies Perspectives Chemical Mixture 11:00 Toxicity

12:00 Registration

13:00

14:00

CE5 CE6 Global Progress in Imaging Technology in 15:00 Genotoxicity and Preclinical and Clinical Carcinogenicity Test Investigations Methods

16:00

17:00

Opening Ceremony

18:00 Exhibition Deichmann Lecture 19:00 Welcome Reception (Lobby, 3F) 20:00

20:30 The XIII International Congress PROGRAM AT A GLANCE 11 of Toxicology

JULY 1 (MON)

Time Lobby Hall B GBR 101 GBR 102 GBR 103GBR 104 GBR 105 Room 203

08:00

Registration

09:00 Keynote Lecture I Kevin Teichman 10:00 Coffee Break (Hall B2) S01 S02 EO1 EO2 S03 W1 Advances in Risk Assessment Keynote and Molecular and Cancer Chemopre- Pesticide 11:00 Biomonitoring for for Food Young Scientist Cellular Toxicity vention: Molecular Exposure during Occupational and Chemicals Session I Mechanisms and Targets and Early – Life Stages Registration Environmental Adverse Health Underlying

Exhibition/ Poster Session Health Outcomes Mechanisms 12:00

Luncheon 13:00 Seminar

14:00 S04 S05 EO3 S06 S07 W2 Risk 21: Accurate, 3D Goes Protein Responses Metabolomics for Preclinical How to Ensure Resource 3R – Complex in to Environmental Discovery of Imaging as an Consumer Safety Appropriate Risk Vitro Methods for Exposures Biomarkers of Approach to of Consumer 15:00 Assessment Modern Toxicity Chemical Toxicity Enhance Products in a Testing and Mechanisms Translational Globalized World? Regulatory Science Coffee Break (Hall B2) 16:00 S08-1 S09 EO4 S10 RT1 W3 Translational Heavy Metal Mechanisms of Update on Towards Improved Energy Crisis, Toxicology: Toxicology: Toxicity: Toxicology in Chemical risk Assessment: Fossil Fuel and International Challenges Application of Update and Genomics-Based Human and Opportunities Biofuels – Adverse 17:00 Basic Sciences to Childhood and Mechanism- Pregnancy Health Effects Clinical Poisoning based Biomarkers Practice-Part1

S08-2 18:00 Translational Toxicology: Application of Basic Sciences to Clinical Practice-Part2

19:00

20:00

20:30 The XIII 12 PROGRAM AT A GLANCE International Congress of Toxicology

JULY 2 (TUE)

Time Lobby Hall B GBR 101 GBR 102 GBR 103 GBR 104 GBR 105 Room 203A Room 203B

08:00

Registration

09:00 Keynote Lecture II Linda S. Birnbaum 10:00 Coffee Break (Hall B2) S11 S12 EO5 S13 S14 W4 Nanotechnology: Stem Cells in OMICS Data, Epigenetic Applications of Threshold of Toxicological 11:00 Toxicology and Toxicology: Bioinformatics Dysregulation PBPK Modeling in Concern (TTC) Approach for Human Health Fundamental and Mathematic During Chemical Risk Assessment the Safety Assessment of Registration Biology and Practical Modeling Carcinogenesis of Environmental Chemical Exhibition/ Poster Session Considerations Contaminants Substances 12:00

13:00 Lunch

14:00 Distinguished Lecture I EO6 OMICS in Jun Kanno Nanotoxicology 15:00 Coffee Break (Hall B2) S15 S16 EO7 W5 W6 RT2 OP1 Are There Joint Symposia EOMICS Target Organ Cellular Phone and Publishing 16:00 Thresholds for USNTP-KNTP Workshop and Toxicology and Electromagnetic Field Trends in Radiation (EFR): Current Genotoxicity? Roundtable Mechanism Status of Safety Toxicology Discussions

17:00

18:00

19:00

20:00

20:30 The XIII International Congress PROGRAM AT A GLANCE 13 of Toxicology

JULY 3 (WED)

Time Lobby Hall B GBR 101 GBR 102 GBR 103GBR 104 GBR 105 Room 203A Room 203B

08:00

Registration

09:00 Keynote Lecture III Sue-Goo Rhee 10:00 Coffee Break (Hall B2) S17 S18 EO8 S19 S20 W7 Recent Topics Complexities and Systems Application of Genetics & Alternative Test Methods 11:00 Epigenetics – The Link about Risk Challenges in Ecotoxicology Systems Biology and International Toxicity and between Individual Assessment of for Cancer Genomes- Regulatory Perspectives Registration Treatment of Nanomaterials Biomarkers Environment Exhibition/ Poster Session for Nano-Safety Organophos- Interaction and Science phate Poisoning Toxicity 12:00

13:00 Lunch

14:00 EO9 Distinguished Lecture II High-throughput Next Robert Barouki Generation Sequencing Methods and Applications 15:00 Coffee Break (Hall B2) S21 S22 EO10 EO11 S23 OP2 OP3 Toxicity of Herbs Free Radical Environmental Human New Risk 16:00 Assessment of & Dietary Toxicology Exposure and Microbiome and Airborne Materials Supplements: Toxicity, an Microbial OMIC and Health Global Efforts at Integrated Technologies in Prevention OMICS Approach Respiratory System 17:00

18:00

Gala Dinner 19:00 (Harmony Ballroom, Coex Intercontinental Hotel, B1)

20:00

20:30 The XIII 14 PROGRAM AT A GLANCE International Congress of Toxicology

JULY 4 (THU)

Time Lobby Hall B GBR 101 GBR 102 GBR 103 GBR 104 GBR 105

08:00

Registration

09:00 Keynote Lecture IV Registration Exhibition Michael Karin 10:00 Coffee Break (Hall B2) S24 S25 W8 S26 S27 Environmental Korean Ginseng : Safety Evaluation for Active Metabolites: The Evidence-based 11:00 Burden of Disease: Efficacy and Safety Biosimilar and Drug Potential Target for Toxicology How to Assess and Development New Drug Discovery Collaboration Prioritize Actions and Toxicity

12:00 Closing Ceremony

13:00

14:00

15:00

16:00

17:00

18:00

19:00

20:00

20:30 The XIII International Congress VENUE LAYOUT 15 of Toxicology

Auditorium

Escalator Auditorium (June 30) Opening Ceremony

Escalator Deichmann Lecture

Lobby (June 30) Welcome Reception

#204 2F #208 (July 3)

ICT Office 208 General Assembly #205

IUTOX Office 204 205 206 Escalator #206 203 #202A 202A Speakers’ Ready Room EOMICS Office Escalator

#203 Scientific Program

Hall B2 Exhibition Poster Session 1F Coffee Break Grand Ballroom #101 ~ #105 Scientific Program Hall B2 105

104

Grand Ballroom Escalator 103 Hall B2 Lobby 102 Registration & 101 Hall B2 Lobby Information Desk Escalator Cloak room

Escalator The XIII 16 CONGRESS INFORMATION International Congress of Toxicology

Registration !"# $'*'$*'$'*'$'

Registration Fee Category Fee Participant USD 750 ! Student USD 350 +;;< USD 200 CE Course +<; =>@Q+Z Gala Dinner Fee +<; USD 120

Registration Fee Includes - The above registration fees for participants include: Welcome reception, coffee breaks, admission to all ;@;\Z;;Z;# - The registration fee for accompanying persons includes: Welcome reception, coffee breaks and tour. +Z;@;;ZZ#

Congress Bag ]ZZ#+\Z with the coupon, which will be in the name badge.

Name Badge Name Badge will be required for admission to all scientific sessions, opening and closing ceremonies and exhibition.

+]@;+Z;;Z_<\ contact to the secretariat after congress.

Internet ]j{$@|#\}ZZ;;#

First Aid & Emergency ;Z;~;~!+Zj]]~] well as the front desk of all the hotels. ;]'!Z+;"\<;"

Congress Secretariat $'Room #204, Coex Tel. +82-2- +]'People-X 1F Haeoreum Bldg., 748-5 Yeoksam-dong, Gangnam-gu, Seoul 135-925, Korea Tel. +82-2-557-8422 Fax. +82-2-566-6087 Email. [email protected] The XIII International Congress CONGRESS INFORMATION 17 of Toxicology

Presentation Guideline (File Submission)

Oral Presentation +}}Z@>}Z+\!" #{_]jZ<Z_>;Q (English version) will be provided. The use of a Macintosh computer with our beam projector ;;#\~>}Z+\!" advance to check the system and to avoid any inconvenience.

Session Schedule

Date Session CE1~CE6 {\>>\jj\{\ {{\@{\>>\jj\{{\\<{ KL III, DL II, S17~S23, W7, EO8~EO11, OP II~OP III KL IV, S24~S27, W8

Speakers’ Ready Room

Date Time Place 15:00 - 18:00 $ 08:00 - 18:00 +\! 08:00 - 12:00

Session Schedule

Date Poster No. P1-001 ~ 314 P2-001 ~ 334 P3-001 ~ 287, EO-P01 ~ 45

Posters will be displayed in the Hall B2 (1F). Posters should be put up by 09:00 and dismantled *'ZZ#+;Z Z;;Z+'$'"#>;Z liable for any lost or damaged posters. The XIII 18 OFFICIAL & SOCIAL PROGRAM International Congress of Toxicology

Opening Ceremony +Z;~Z;#<Z; ;{]# $@''$*' $<;'+Z\!

Welcome Reception +Z;Z;;~Z# $@''$' $<;'+Z\!

General Assembly @Z{=_>;Z~ZZ+# $@''$' $<;'*\!

Spouse Program +;;Z#\ Bongeunsa” is for those who want a brief experience of both Korea and Buddhist cultures. Basic programs include the temple tore, tea ceremony, meditation and making lotus lanterns. $@''$' - Place : Bongeunsa Temple - Fee: Free of charge <}{Z}#!;\@~Z\_#" ;Zj\#

Gala Dinner +;ZZ;;Z; the ICT2013. Do not miss this special chance to meet participants from all around the world. It will surely the highlight of the social program and a memorable night, where you will leave with memories to take home from Korea. $@'*'$' -Place : Harmony Ballroom, Coex Intercontinental Hotel, B1 -Fee : USD 120

Closing Ceremony The closing ceremony will be held to celebrate the success of programs and to cherish the memories form the ICT2013. $@''$' $<;'\! DAILY PROGRAM

Plenary Lecture June 30 July 1 July 2 July 3 July 4 The XIII 20 PLENARY LECTURE International Congress of Toxicology

DEICHMANN LECTURE June 30 (Sun), 18:00-19:00 Chair : Daniel Acosta (University of Cincinnati, USA) Auditorium (3F) A Systemic Review of the Prothrombotic Risk of Xenobiotics: From Cell to System Jin-Ho Chung (Seoul National University, Korea)

KEYNOTE LECTURE I July 1 (Mon), 09:00-10:00 Chair : Yue Ge (US Environmental Protection Agency, USA) GBR 101-105 (1F) Environmental Omics: A Systems Biology Approach to Research on Environmental Stress and Health Kevin Y Teichman (US Environmental Protection Agency, USA)

KEYNOTE LECTURE II July 2 (Tue), 09:00-10:00 Chair : Torbjorn Malmfors (Malmfors Consulting, Sweden) GBR 101-105 (1F) Our Environment, Our Health: You Can't Change Your Genes, but You Can Change Your Environment Linda Birnbaum (NTP/NIEHS, USA)

KEYNOTE LECTURE III July 3 (Wed), 09:00-10:00 Chair : Frank J Gonzalez (National Cancer Institute, USA) GBR 101-105 (1F) Adverse and Beneﬁ cial Effects of Reactive Oxygen Species Produced by Cytochrome Sue Goo Rhee (Yonsei University, Korea)

KEYNOTE LECTURE IV July 4 (Thu), 09:00-10:00 Chair : Myung-Hee Chung (Sungkyunkwan University, Korea) GBR 101-105 (1F) Virchow Explained: The Origin of Tumor Elicited Inﬂ ammation and its Signiﬁ cance Michael Karin (University of California San Diego, USA)

DISTINGUISHED LECTURE I July 2 (Tue), 14:00-15:00 Chair : Nancy Claude (I.R.I.Servier, France) GBR 101-105 (1F) Percellome Toxicogenomics: A Quantitative and Comprehensive Approach for Basic and Applied Toxicology Jun Kanno (NIHS, Japan)

DISTINGUISHED LECTURE II July 3 (Wed), 14:00-15:00 Chair : Herman Autrup (University of Aarhus, Denmark) GBR 101-105 (1F) The Role of Adipose Tissue in Toxicology Robert Barouki (University Paris Descartes, France) The XIII International Congress DAILY PROGRAM / JUNE 30 (SUN) 21 of Toxicology

* This session is organized by "Center for Multi-organ Interaction Toxicity"

CE Course 1 09:30 ~ 12:30, GBR 101 (1F) Application of Biomarkers for Predictive Toxicology (Omics, MicroRNA, etc.) Chairs : Weida Tong (NCTR/FDA, USA), Juergen Borlak (Hannover Medical School, Germany)

09:30 - 09:50 A Decade of Toxicogenomic Research Offers Unprecedented Opportunities Weida Tong (NCTR/FDA, USA)

09:50 - 10:20 The Japanese Toxicogenomics Project: Collaborative Efforts on Developing Open TG-GATEs Database and Creation of Toxicogenomic Biomarkers Takeki Uehara (Shionogi & Co., Ltd, Japan)

10:20 - 11:00 Toxicology Model Building Based on Omics Datasets for the Prediction of Non-Genotoxic Liver Carcinogenesis Juergen Borlak (Hannover Medical School, Germany)

11:00 - 11:40 From Transcriptomics to RNAi-based Functional Genomics: Uncovering the Breaking Points of Toxicity Bob van de Water (Leiden University, Netherlands)

11:40 - 12:10 Data Common and Sharing – A Path Towards Advancing Biomedical Science Susanna-Assunta Sansone (University of Oxford, United Kingdom)

12:10 - 12:30 Predicting Individuals Susceptible to APAP-Induced Liver Injury by Predose Transcriptional Proﬁ ling Xiaohui Fan (Zhejiang University, China)

CE Course 2 09:30 ~ 12:30, GBR 102 (1F) Statistical Modeling and Data Analysis for Toxicological and Clinical Studies Chair : Donguk Kim (Sungkyunkwan University, Korea)

09:30 - 10:00 Principle and Application of Statistical Methods in Toxicology James J. Chen (FDA, USA)

10:00 - 10:30 Statistical Modeling and Data Analysis for Toxicological and Clinical Studies Jessica Kim (FDA, USA)

10:30 - 11:00 Statistical Decision-Making Algorithms for Toxicological and Clinical Studies Hojin Moon (California State University, USA)

11:00 - 11:30 Statistical Application in Toxicological Studies Taewon Lee (Korea University, Korea)

11:30 - 12:00 Robust Multivariate Signal Detection for Clinical Laboratory Safety Data Monitoring and Assessment Kwan R. Lee (GlaxoSmithKline, USA)

12:00 - 12:30 Estimation of Drug Response Heritability Using Clinical Trial Data: an Application of Mixed Model Kijoung Song (GlaxoSmithKline, USA) The XIII 22 DAILY PROGRAM / JUNE 30 (SUN) International Congress of Toxicology

* This session is organized by "Center for Multi-organ Interaction Toxicity"

CE Course 3 09:30 ~ 17:00, GBR 103 (1F) Risk Assessment: Principles, Application and Future Perspectives Chairs : Elaine M. Faustman (University of Washington, USA), Byung-Mu Lee (Sungkyunkwan University, Korea)

09:30 - 09:45 Introduction and Welcome Elaine M. Faustman (University of Washington, USA) / Byung-Mu Lee (Sungkyunkwan University, Korea) 09:45 - 10:30 Risk Assessment Issues and Challenges: Deﬁ ning the Questions and Obtaining the Data Wallace Hayes (Harvard School of Public Health, USA) 10:30 - 11:15 Current Status and Future Direction of Risk Assessment Byung-Mu Lee (Sungkyunkwan University, Korea) 11:15 - 12:00 Quantitative Risk Assessment Approaches: Integrating Dose Response with Exposure Assessment Elaine M. Faustman (University of Washington, USA) 12:00 - 12:15 Break 12:15 - 13:00 Risk Characterization Using Mode of Action Concepts Wallace Hayes (Harvard School of Public Health, USA) / Elaine M. Faustman (University of Washington, USA) 13:00 - 13:30 Questions and Answers 13:30 - 14:30 Lunch 14:30 - 15:15 Nanoengineered Materials Herman Autrup (University of Aarhus, Denmark) 15:15 - 16:00 Successful Lessons from Using Mechanistic Data for Pharmaceutical Assessment Lewis Smith (University of Leicester, United Kingdom) 16:00 - 16:15 Break 16:15 - 16:45 Risk Assessment within REACH: Successes and Lessons Learned Heidi Foth (Martin Luther University, Germany) 16:45 - 17:00 Closing Remarks and Invitation to RA Poster Session

CE Course 4 09:30 ~ 13:00, GBR 104 (1F) An Integrated OMICS Approach & Nanoinformatics for Chemical Mixture Toxicity Chair : Yue Ge (US Environmental Protection Agency, USA)

09:30 - 10:10 Predictive Protein Responses of Human Cells to Chemical Mixtures Yue Ge (US Environmental Protection Agency, USA) 10:10 - 10:50 Reproducibility of Predictive Biomarkers in Toxicogenomics Cesare Furlanello (Fondazione Bruno Kessler, Italy) 10:50 - 11:30 The Next-Generation Sequencing Quality Control Project Leming Shi (Fudan University, China) The XIII International Congress DAILY PROGRAM / JUNE 30 (SUN) 23 of Toxicology

11:30 - 12:10 Gene Expression Proﬁ ling as an Initial Approach for Mechanistic Studies of Toxicity and Tumorigenicity Herbal Plants Lei Guo (NCTR/FDA, USA) 12:10 - 12:50 Characterization of Toxicity by Genome-Wide Network-Based Pathway Analysis Carlos Roca (Universitat Rovira i Virgili, Spain) 12:50 - 13:00 Closing Remarks

CE Course 5 14:00 ~ 16:30, GBR 102 (1F) Global Progress in Genotoxicity and Carcinogenicity Test Methods Chair : Takehiko Nohmi (NIHS, Japan)

14:00 - 14:30 Introduction: Genotoxicology and Carcinogenesis Takehiko Nohmi (NIHS, Japan) 14:30 - 15:00 Global Progress in Genotoxity and Carcinogenicity Test Methods Anthony Lynch (GlaxoSmithKline, United Kingdom) 15:00 - 15:30 Micronucleus Assays to Study Genotoxicity and Carcinogenesis Michael Fenech (CSIRO, Australia) 15:30 - 16:00 Epigenetic Actions of Environmental Agents Toshikazu Ushijima (National Cancer Center Research Institute, Japan) 16:00 - 16:30 Trends in Chemical Carcinogenesis Samuel Cohen (University of Nebraska Medical Center, USA)

CE Course 6 14:00 ~ 16:30, GBR 104 (1F) Imaging Technology in Preclinical and Clinical Investigations Chair : Jae Beom Kim (PerkinElmer, USA), Kevin Francis (Imperial College, United Kingdom)

14:00 - 14:30 Introduction to Preclinical PET and SPECT Imaging Jae Sung Lee (Seoul National University, Korea) 14:30 - 15:00 Molecular Imaging for siRNA Delivery System Kwangmeyung Kim (KIST, Korea) 15:00 - 15:30 Visualizing Disease Events and Drug Eﬃ cacy Studies in Vivo Using Optical Imaging Kevin Francis (Imperial College, United Kingdom) 15:30 - 16:00 Molecular Imaging-Based PK/PD Studies Sang Eun Kim (Seoul National University, Korea) 16:00 - 16:30 Tools for Studying Cellular and Molecular Biology in Living Subjects Christopher Contag (Stanford University, USA)

17:00 - 18:00 Opening Ceremony / Auditorium (3F) 19:00 - 20:00 Welcome Reception / Auditorium Lobby (3F) The XIII 24 DAILY PROGRAM / JULY 1 (MON) International Congress of Toxicology

10:30 - 12:00 S01 : Advances in Biomonitoring for Occupational and Environmental GBR 101 (1F) Health Chairs : Maurizio Manno (University of Naples Federico II, Italy) Byung-Mu Lee (Sungkyunkwan University, Korea) S01-1 Biomonitoring for Occupational Health Risk Assessment: State of the Art Maurizio Manno (University of Naples Federico II, Italy) S01-2 Biomarkers of Nanomaterial Exposure and Effect: Current Status Ivo Iavicoli (Catholic University of Sacred Heart, Italy) S01-3 Urine Versus Kidney Cadmium in an Environmentally Exposed Population Magnus Akerstrom (University of Gothenburg, Sweden) S01-4 Metabolomic Assessment of Cisplatin-Induced Idiopathic Toxicity Sunghyouk Park (Seoul National University, Korea)

10:30 - 12:00 S02 : Risk Assessment for Food Chemicals GBR 102 (1F) Chairs : Meehye Kim (Ministry of Food and Drug Safety, Korea) A. Wallace Hayes (Harvard University, USA) S02-1 Risk Assessment of Heat-Induced Contaminants (MCPD Fatty Acid Esters) and the Impact of New Oral Bioavailability Data Alfonso Lampen (Federal Institute for Risk Assessment, Germany) S02-2 Brief Introduction of Works in Food Safety Risk Assessment in China Li Ning (China National Center for Food Safety Risk Assessment, China) S02-3 Risk Assessment of Dioxins in Food for Korean Population Jung Hyuck Suh (National Institute of Food and Drug Safety, Korea) S02-4 Food Contact Materials and the Migration of Chemicals into Foods Jutta Tentschert (German Federal Institute for Risk Assessment, Germany) S02-5 Dietary Exposure Assessment of Trans-Fatty Acids in China Zhaoping Liu (China National Center for Food Safety Risk Assessment, China)

10:30 - 12:00 EO1 : Keynote and Young Scientist Session I GBR 103 (1F) Chair : Dazhi Wang (Xiamen University, China) EO1-1 The Epigenome, Transcriptome and Metabolome associated with Carcinogenesis in Fish from the Environment James K Chipman (The University of Birmingham, United Kindom) EO1-2 Metagenomic Analysis of Size Classiﬁ ed Particle in Atmosphere Shogo Takehisa (Gifu University, Japan) EO1-3 Changing of Gene Expression in Controlling the Exposure Condition Using Passive Dosing Ji-Yeon Roh (Korea University, Korea) EO1-4 Shotgun Proteomic Analysis Reveals Highly Expressed Proteins and the Biological Processes Occurred in the Blooming Cells of a Diatom Skeletonema Costatum (Bacillariophyceae) Hao Zhang (Xiamen University, China) EO1-5 Differential Mode of Biological Interaction of Graphene Oxide (GO) vs Reduced Graphene Oxide (rGO) Nivedita Chattergee (University of Seoul, Korea) The XIII International Congress DAILY PROGRAM / JULY 1 (MON) 25 of Toxicology

10:30 - 12:00 EO2 : Molecular and Cellular Toxicity Mechanisms and Adverse Health GBR 104 (1F) Outcomes I Chair : Yiguo Jiang (Guangzhou Medical University, China) EO2-1 Toxicogenomic Study of Comfrey and Riddelliine in Rat Livers Nan Mei (FDA/NCTR, USA) EO2-2 Trimethyltin Chloride Exposure Chronically and the Risk of Developing Nephrolithiasis Xiaojiang Tang (Guangdong Medical Laboratory Animal Center, China) EO2-3 Pattern Formation by Controlling Cell Movement Chenli Liu (The University of Hongkong, Hong Kong) EO2-4 The Roles and Mechanisms of MicroRNAs in Chemically Induced Lung and Gastric Carcinogenesis Yiguo Jiang (Guangzhou Medical University, China) EO2-5 Proteomic and Phosphoproteomic Determination of the Asynchronous Filling of Superior and Inferior Spikelets in Rice (Oryza Sativa. L) Zhixing Zhang (Fujian Agriculture and Forestry University, China) EO2-6 Genotoxicity of Benzene and its Hydroxylated Metabolites in V79-hCYP2E1-hSULT1A1 Cells Yungang Liu (Southern Medical University, China)

10:30 - 12:00 S03 : Cancer Chemoprevention: Molecular Targets and Underlying GBR 105 (1F) Mechanisms Chairs : Young-Joon Surh (Seoul National University, Korea) F. P Guengerich (Vanderbilt University School of Medicine, USA) S03-1 Natural Compounds as Inhibitors of the 10 Hallmarks of Cancer Marc Diederich (Seoul National University, Korea) S03-2 Enzymes Involved in Metabolism of Carcinogens: Which Should be Modulated? F. P Guengerich (Vanderbilt University School of Medicine, USA) S03-3 Epigenetics of Dietary Phytochemicals in Cancer Prevention: A Focus on Nrf2 Pathway Ah-Ng T Kong (Rutgers University, USA) S03-4 Xenohormetic Phytochemicals with Cancer Chemopreventive Potential Young-Joon Surh (Seoul National University, Korea) S03-5 Induction of DNA Repair in Cancer Protection and Therapy Bernd Kaina (University Medical Center, Germany)

10:30 - 12:00 W1 : Pesticide Exposure during Early - Life Stages Room 203 (2F) Chairs : Sameeh A Mansour (National Research Centre, Egypt) Laurence Gamet-Payrastre (The National Institute for Agricultural Research, France) W1-1 Impact of Pesticide Exposure during Gestation and Lactation Sameeh A Mansour (National Research Centre, Egypt) W1-2 Dietary Exposure to a Low Dose of Pesticides Alone or as a Mixture: Impact on Hematopoiesis Laurence Gamet-payrastre (The National Institute for Agricultural Research, France) W1-3 The Metabonomic Approach Based on 1H NMR used to Learn about Biological Fingerprint upon Pesticides Exposure Cecile Canlet (The National Institute for Agricultural Research, France) The XIII 26 DAILY PROGRAM / JULY 1 (MON) International Congress of Toxicology

W1-4 Estrogenicity of Methoxychlor as an Endocrine Disrupting Chemical Kyung-Chul Choi (Chungbuk National University, Korea)

12:30 - 13:30 Luncheon Seminar (Sponsored by Harlan Laboratories) GBR 103 (1F) Chair : Hyung Sik Kim (Sungkyunkwan University, Korea)

Toxicity of Vehicle and Co-Solvent Ciriaco Maraschiello (CRS Harlan Laboratories, Spain)

14:00 - 15:30 S04 : Risk 21: Accurate, Resource Appropriate Risk Assessment GBR 101 (1F) Chairs : Timothy Pastoor (Syngenta, USA) Alan R Boobis (Imperial College London, United Kingdom) S04-1 Why the Need for RISK21 Alan R Boobis (Imperial College London, United Kingdom) S04-2 The RISK21 Roadmap and Matrix Timothy Pastoor (Syngenta, USA) S04-3 RISK21 Case Studies Douglas C Wolf (U. S. Environmental Protection Agency, USA) S04-4 Applications to Cumulative Risk Angelo Moretto (University of Milano, Italy)

14:00 - 15:30 S05 : 3D Goes 3R - Complex in Vitro Methods for Modern Toxicity Testing GBR 102 (1F) Chairs : Ellen Fritsche (IUF - Leibniz Research Institute for Environmental Medicine, Germany) Elaine M Faustman (University of Washington, USA) S05-1 Introduction into 3D in Vitro Methods: Lessons from Skin and Brain Ellen Fritsche (IUF - Leibniz Research Institute for Environmental Medicine, Germany) S05-2 A New 3D Human Corneal Epithelium Model Reconstituted with Human Limbal Epithelial Cells and its Application to Eye Irritation Tests Kyung-Min Lim (Ewha Womans University, Korea) S05-3 A Novel Organotypic 3D Liver Model for Toxicity Studies Simon Messner (InSphero AG, Switzerland) S05-4 Innovative 3D Testicular Models for Toxicity Testing Elaine M Faustman (University of Washington, USA)

14:00 - 15:30 EO3 : Protein Responses to Environmental Exposures GBR 103 (1F) Chairs : Yue Ge (US Environmental Protection Agency, USA) Wenxiong Lin (Fujian Agricultural and Forestry University, China) EO3-1 Protein Responses of Human Lung Epithelial Cells to Deﬁ ned Metal Mixtures Yue Ge (US Environmental Protection Agency, USA) EO3-2 Heterogeneous Interactome between Host and Pathogens Hui Li (Sun Yat-Sen University, China) EO3-3 iTRAQ Labeling Quantitative Proteomics Analysis Antibiotic Resistance Mechanism in Lamb Mutant Strain Xiangmin Lin (University of Washington, USA) The XIII International Congress DAILY PROGRAM / JULY 1 (MON) 27 of Toxicology

EO3-4 Phosphoproteome Analysis Reveals an Important Role for Glycogen Synthase Kinase-3 in Perﬂ uorododecanoic Acid-induced Rat Liver Toxicity Hongxia Zhang (Chinese Academy of Sciences, China) EO3-5 Characterization of Protein Species and Weighted Protein Co-expression Network Regulation of Escherichia Coli in response to Serum Killing using 2-DE based Proteomics Approach Zhixue Chen (Sun Yat-Sen University, China) EO3-6 Quantitative Proteomic Analysis of Sparus Macrocephlus Small Intestine and Liver Acute Exposure to Ockadaic Acid Minghua Wang (Xiamen University, China)

* This session is organized by "Center for Multi-organ Interaction Toxicity" 14:00 - 15:30 S06 : Metabolomics for Discovery of Biomarkers of Chemical Toxicity GBR 104 (1F) and Mechanisms Chairs : Frank J Gonzalez (National Institutes of Health, USA) Ali E Karakaya(Gazi University, Turkey) S06-1 Metabolomics for Discovery of Biomarkers of Chemical Toxicity and Mechanisms Frank J Gonzalez (National Institutes of Health, USA) S06-2 The Footprints of Gut Microbial - Mammalian Co-Metabolism Wei Jia (University of Hawaii Cancer Center, USA) S06-3 Identiﬁ cation of Endogenous Metabolic Markers and their Combination for CYP3A Activity Using Metabolic Proﬁ ling and Midazolam Pharmacokinetics Joo Youn Cho (Seoul National University, Korea) S06-4 Metabolomics in the Monitoring of Drug Safety Renke Dai (South China University of Technology, China)

14:00 - 15:30 S07 : Preclinical Imaging as an Approach to Enhance Translational GBR 105 (1F) Regulatory Science Chairs : William Slikker, Jr. (NCTR, USA) Keon Wook Kang (Seoul National University, Korea) S07-1 Imaging Approaches for Use as Preclinical Assessment Tools: An Overview William Slikker, Jr. (NCTR, USA) S07-2 Imaging as an Approach to Deﬁ ne Nervous System Toxicology William Slikker, Jr. (NCTR, USA) S07-3 In Vivo Molecular Imaging for Drug Development Keon Wook Kang (Seoul National University, Korea) S07-4 Translational PET Imaging for Safety Assessment Shintaro Nishimura (Astellas Pharma Inc., Japan)

14:00 - 15:30 W2 : How to Ensure Consumer Safety of Consumer Products in a Room 203 (2F) Globalized World? Chairs : Seok Kwon (Procter & Gamble, Singapore) Yohan Yoon (Sookmyung Women's University, Korea) W2-1 An Exposure-Based Risk Assessment Approach to Safety Evaluation of Consumer Products Seok Kwon (Procter & Gamble, Singapore) The XIII 28 DAILY PROGRAM / JULY 1 (MON) International Congress of Toxicology

W2-2 Risk Assessment of Impurities Found in a Consumer Product: Use of Hemoglobin Adducts to Determine Human Exposure to Reactive Chemicals Toshio Kasamatsu (Kao Corporation, Japan) W2-3 Development of Non-animal Safety Assessment System in Shiseido Morihiko Hirota (Shiseido Research Center, Japan) W2-4 Speciﬁ c Aspects When Assessing the Consumer Safety of Hair Care Products Heike Scheﬄ er (Procter&Gamble, China) W2-5 The Safety Evaluation for Cosmetics and Cosmetic Raw Materials in China Zhang H Wei (China CDC, China)

16:00 - 17:30 S08-I : Translational Toxicology: Application of Basic Sciences to Clinical GBR 101 (1F) Practice-Part1 Chairs : Robert S Hoffman (American Academy of Clinical Toxicology, USA) Knut Erik Hovda (Oslo University Hospital, Norway) S08 I-1 Translation of Mechanistic Studies on Glycol-induced Renal Toxicity into Potential Antidotes Kenneth E Mcmartin (Louisiana State University Health Science Center - Shreveport, USA) S08 I-2 Formate Analysis for the Diagnosis of Methanol Poisoning: From a Basic Research Tool to a Diagnostic Tool for the Future Knut Erik Hovda (Oslo University Hospital, Norway) S08 I-3 The Use of Intravenous Fat Emulsion Therapy to Alter Systemic Distribution of Cardiac Toxins Grant Cave (Tamworth Hospital, New Zealand) S08 I-4 Cocaine Poisoning. Enhancement of Normal Metabolism to Limit Toxicity Robert S Hoffman ( American Academy of Clinical Toxicology, USA)

16:00 - 17:30 S09 : Heavy Metal Toxicology: Update and Childhood Poisoning GBR 102 (1F) Chairs : Curtis D Klaassen (University of Kansas Medical Center, USA) Akira Naganuma(Tohoku University, Japan) S09-1 Pathophysiology & Treatment of Childhood Lead Poisoning Alan D Woolf (Boston Children's Hospital & Harvard Medical School, USA) S09-2 Genetic Susceptibility to Chemicals is a New Field That Addresses Robert Wright (Mount Sinai School of Medicine, USA) S09-3 Protective Mechanisms of Cells Against Cadmium Toxicity Curtis D Klaassen (University of Kansas Medical Center, USA) S09-4 Screenings for Proteins that Inﬂ uence Sensitivity of Cells to Methylmercury Akira Naganuma (Tohoku University, Japan) S09-5 Overview of the Childhood Lead Poisoning Outbreak in Zamfara, Nigeria 2010 to Date Paul I Dargan (Guy's and St Thomas' NHS Foundation Trust, United Kingdom) S09-6 Low-level Lead Toxicity: The Ongoing Search for a Threshold Bruce P Lanphear (Simon Fraser University, Canada) The XIII International Congress DAILY PROGRAM / JULY 1 (MON) 29 of Toxicology

16:00 - 17:30 EO4 : Mechanisms of Toxicity: Genomics-based and Mechanism-based GBR 103 (1F) Biomarkers Chairs : Nan Mei (FDA/NCTR, USA) Chenli Liu (The University of Hongkong, Hong Kong) EO4-1 Identifi cation of Arsenic induced Toxicity and Susceptible Individuals through Genetic, Genomic and Proteomic Approaches Ashok K Giri (Indian Institute of Chemical Biology, India) EO4-2 Standardization of Microarray Measurement by using of Standard Materials : For an Applications of Expression Analysis Hiroki Nakae (Japan Microarray Consortium, Japan) EO4-3 Identifi cation of Serum Biomarkers for Occupational Medicamentosa-like Dermatitis induced by Trichloroethylene using Mass Spectrometry Wenxu Hong (Shenzhen Center for Disease Control and Prevention, China) EO4-4 Application of Microarray in Studying Herbal Dietary Supplements associated Toxicity and Underlying Mechanism Lei Guo (National Center for Toxicological Research/FDA, USA) EO4-5 Changes in Rice Allelopathy and Rhizosphere Microfl ora by Inhibiting Rice Phenylalanine Ammonia- lyase Gene Expression Changxun Fang (Fujian Agriculture and Forestry University, China)

16:00 - 17:30 S10 : Update on Toxicology in Human Pregnancy GBR 104 (1F) Chairs : Simon H Thomas (UK Teratology Information Service, United Kingdom) Laura M Yates (UK Teratology Information Service, United Kingdom) S10-1 New Insights into the Mechanisms of Teratogenesis Laura M Yates (UK Teratology Information Service, United Kingdom) S10-2 Beneﬁ ts and Pitfalls of Animal Research for Predicting Adverse Fetal Effects of Drugs and Chemicals in Humans William Webster (University of Sydney, Australia) S10-3 Epidemiologic Methods for Detecting Adverse Fetal Effects of Human Exposure to Medicines During Pregnancy Christina Chambers (University of California San Diego, USA) S10-4 Communicating Information on Risks and Beneﬁ ts of Medicines Used in Pregnancy Debra Kennedy (Mothersafe, Royal Hospital for Women, Australia) S10-5 Poisoning and Drug Overdose in Pregnancy Simon H Thomas (UK Teratology Information Service, United Kingdom)

16:00 - 17:00 RT 1 : Towards Improved Chemical Risk Assessment: International GBR 105 (1F) Challenges and Opportunities Chair : Becki Clark (US Environmental Protection Agency, USA) RT 1-1 Incorporation of High-throughput Data in Risk Assessment Linda Birnbaum (NTP/NIEHS, USA) RT 1-2 Tox21 Daniel Krewski (The University of Ottawa, Canada) The XIII 30 DAILY PROGRAM / JULY 1 (MON) International Congress of Toxicology

RT 1-3 The IARC Monographs: From Hazard Identiﬁ cation to Risk Assessment Kurt Straif (IARC, France) RT 1-4 Global Institutional Networking to Strengthen Chemical Risk Assessment Carolyn Vickers (World Health Organization, Switzerland)

16:00 - 17:30 W3 : Energy Crisis, Fossil Fuel and Biofuels - Adverse Health Effects Room 203 (2F) Chair : Herman Autrup (University of Aarhus, Denmark) W3-1 Toxicological Effects of Particulate Emissions from Biomass Combustion Pasi I Jalava (University of Eastern Finland, Finland) W3-2 Health Risk Assessment of Exhaust from Conventional and New Technology Engines Paul T Scheepers (Radboud University, Netherlands) W3-3 Occupational Exposure to Mercury and Benzene in Petrochemical Industries Salmaan H Inayat-hussain (Universiti Kebangsaan Malaysia, Malaysia)

17:40 - 18:40 S08-II : Translational Toxicology: Application of Basic Sciences to GBR 101 (1F) Clinical Practice-Part2 Chair : Eugenio Vilanova (University 'Miguel Hernandez', Spain) S08 II-1 Translation of Pharmacologic and Toxicologic Effects of Biopharmaceuticals in Nonclinical Studies to Observations in Humans Ikuo Horii (Pﬁ zer Japan Inc., Japan) S08 II-2 Respiratory Toxicity of Maintenance Therapy in Drug Addicts: Contribution of Animal Models Bruno Megarbane (INSERM U705, Paris-Diderot University, France) S08 II-3 From Toxicology to Clinic: A Systems Medicine Approach Based on Biomarkers Stefano Bonassi (IRCCS San Raffaele, Italy) The XIII International Congress DAILY PROGRAM / JULY 2 (TUE) 31 of Toxicology

10:30 - 12:00 S11 : Nanotechnology: Toxicology and Human Health GBR 101 (1F) Chairs : Kai M Savolainen (Finnish Institute of Occupational Health, Finland) Jean-Roger Claude (University Rene Descartes, France) S11-1 Predictive Risk Assessment of Engineered Nanomaterials Kai M Savolainen (Finnish Institute of Occupational Health, Finland) S11-2 Understanding Interations of Engineered Nanomaterials with Biological Systems: Omics/ Systems Biology Approaches Bengt Fadeel (Karolinska Institutet, Sweden) S11-3 Mechanisms of Nanomaterial Induced Pulmonary Inﬂ ammation Harri Alenius (Finnish Institute of Occupational Health, Finland) S11-4 Genotoxicity of Carbon Nanotubes Il Je Yu (Hoseo University, Korea)

10:30 - 12:00 S12 : Stem Cells in Toxicology: Fundamental Biology and Practical GBR 102 (1F) Considerations Chairs : Kyung-Sun Kang (Seoul National University, Korea) James E Trosko (Michigan State University, USA) S12-1 The Presence of Very Small Embryonic like Stem Cells (VSELs) in Adult Tissues and an Emerging Role of Microvesicles, Exosomes and Paracrine Signals in Regenerative Medicine Mariusz Ratajczak (University of Louisville, USA) S12-2 IRole of Genetic and Environmental Factors on Pre-Disposition to Diseases Later in Life: Alteration of the Quality & Quantity of Organ-Speciﬁ c Adult Stem Cells as the Basis for the Barker Hypothesis James E Trosko (Michigan State University, USA) S12-3 Drug Screening and High Through-put Toxicological Prescreening using Human Stem Cells and Cancer Stem Cells Kyung-Sun Kang (Seoul National University, Korea) S12-4 Evaluation of Developmental Toxicity Using Mouse and Human Embryonic Stem Cell Eui-Bae Jeung (Chungbuk National University, Korea) S12-5 3D Models for in Vitro Toxicological Testing Andreas Kurtz (Charite University Medicine Berlin, Germany)

10:30 - 12:00 EO5 : OMICS Data, Bioinformatics and Mathematic Modeling GBR 103 (1F) Chairs : Jake Chen (Indiana University, USA) Senjie Lin (University of Connecticut, USA) EO5-1 Semantic Link Predication for Drug Discovery Ying Ding (Indiana University, USA) EO5-2 Genome-scale Meta-analysis of Type-2 Diabetes Genetic Risk Markers Jake Chen (Indiana University, USA) EO5-3 Discovery-driven Biomedical Full-text Mining with Graph Model Min Song (Yonsei University, Korea) EO5-4 Nanoinformatics for Nanosafety Assessment Robert Rallo (Universitat Rovira i Virgili, Spain) EO5-5 The Application of Omics Techniques in the study of DNA Damage Response Jun Yang (Hangzhou Normal University, China) The XIII 32 DAILY PROGRAM / JULY 2 (TUE) International Congress of Toxicology

10:30 - 12:00 S13 : Epigenetic Dysregulation During Chemical Carcinogenesis GBR 104 (1F) Chairs : Regina Santella (Columbia University, USA) Jeung Whan Han (Sungkyunkwan University, Korea) S13-1 DNA Methylation Biomarkers in Molecular Epidemiology Studies of Cancer Regina Santella (Columbia University, USA) S13-2 Aberrant Methylation and lncRNAs Expression Signatures during Malignant Transformation of Human Bronchial Epithelial Cells Induced by Cadmium Yi-xiong Lei (Guangzhou Medical University, China) S13-3 Epigenetic Dysregulation during Chemical Carcinogenesis Wen Chen (Sun Yat-Sen University, China) S13-4 Depletion of Embryonic Stem Cell Signature by Epigenetic Regulation of Nanog Gene in NCCITCells Jeung Whan Han (Sungkyunkwan University, Korea)

10:30 - 12:00 S14 : Applications of PBPK Modeling in Risk Assessment of GBR 105 (1F) Environmental Contaminants Chairs : James V Bruckner (University of Georgia, USA) Kyu-Bong Kim (Dankook University, Korea) S14-1 Incorporation of Maturational Changes in Pyrethroid Kinetics into PBPK Models for Children James V Bruckner (University of Georgia, USA) S14-2 Evaluating Early Life Sensitivity to Pyrethroids by Physiologically Based Pharmacokinetic (PBPK) Modeling Supported by in Vitro Data Miyoung Yoon (The Hamner Institutes for Health Sciences, USA) S14-3 Derivation of Chemical-Speciﬁ c Assessment Factors by Population PBPK Modeling Gunnar Johanson (Karolinska Institutet, Sweden) S14-4 Acrylonitrile Concentrations Hypothetically Modeled in Humans Hiroshi Yamazaki (Showa Pharmaceutical University, Japan) S14-5 Risk Assessment of Cadmium Using Physiologically-based Pharmacokinetic (PBPK) Modeling for Korean Population Kyu-Bong Kim (Dankook University, Korea)

10:30 - 12:00 W4 : Threshold of Toxicological Concern (TTC) Approach for the Safety Room 203 (2F) Assessment of Chemical Substances Chairs : Corrado L Galli (University of Milan, Italy) Alan Boobis (Imperial College London, United Kingdom) W4-1 Applıcatıon of the TTC Concept to Unknown Substances Found in Analysıs of Foods Corrado L Galli (University of Milan, Italy) W4-2 Use of Threshold of Toxicological Concern (TTC) in the Risk Assessment for Cosmetics and Personal Care Products Petra S Kern (Procter & Gamble Ltd., China) W4-3 Application of TTC on Drug Impurities Sang-Hee Jeong (Hoseo Toxicology Reasearch Center, Korea) 12:00 - 14:00 Lunch The XIII International Congress DAILY PROGRAM / JULY 2 (TUE) 33 of Toxicology

14:00 - 15:15 EO6 : OMICS in Nanotoxicology Room 203 (2F) Chairs : Katsuhide Fujita (National Institute of Advanced Industrial Science and Technology, Japan) Hitoshi Iwahashi (Gifu University, Japan) EO6-1 Essential Protocols for Starting in Vitro Evaluation of Nanoparticle Hitoshi Iwahashi (Gifu University, Japan) EO6-2 Effects of Single-wall Carbon Nanotubes on Gene Expressions in Rat Alveolar Macrophages Katsuhide Fujita (National Institute of Advanced Industrial Science and Technology, Japan) EO6-3 Effects of Residual Metals involved in Single-wall Carbon Nanotubes on Oxidative Stress Response in Human Type II Alveolar Epithelial Cell Lines Makiko Fukuda (Technology Research Association for Single Wall Carbon Nanotubes, Japan) EO6-4 Neurotoxicity of Silica Nanoparticles: Brain Localization, Alzheimer’s Disease-like Pathology and Spatial Memory Impairment Xifei Yang (Shenzhen Center for Disease Control and Prevention, China) EO6-5 Role of miRNA Proﬁ ling on Silver Nanoparticles-induced DNA Damage in Jurkat T Cells Hyun-Jeong Eom (University of Seoul, Korea)

15:30 - 17:00 S15 : Are There Thresholds for Genotoxicity? GBR 101 (1F) Chair : Jennifer Y Tanir (ILSI Health and Environmental Sciences Institute, USA) Kyunghee Choi (National Institute of Environmental Research, Korea) S15-1 Impact of Moving from Qualitative to Quantitative Approach on Genotoxicity Risk Assessment Anthony M Lynch (GSK, United Kingdom) S15-2 A Critical Assessment of Low Dose Responses in Genetic Toxicology B. Bhaskar Gollapudi (Cardno ENTRIX, USA) S15-3 Mechanisms Underlying the Non-linear Dose-responses for DNA-reactive Genotoxicants George E Johnson (Swansea University, United Kingdom) S15-4 DNA Repair and Translesion DNA Synthesis as Constituents of “Threshold” of Genotoxicity Takehiko Nohmi (National Institute of Health Sciences, Japan) S15-5 Threshold of Genotoxic Carcinogens: Conclusion from Mechanism-Based Carcinogenicity Studies Shoji Fukushima (Japan Industrial Safety & Health Association, Japan)

15:30 - 19:00 S16 : National Coordination of Toxicology Research and Testing: GBR 102 (1F) Perspectives from the Korea and US “National Toxicology Programs” Chairs : Linda Birnbaum (NTP/NIEHS, USA) Won Guen Seong (KNTP/NIFDS, Korea) S16-1 Introduction to the Session and a Brief History of the US National Toxicology Program John Bucher (NIEHS, USA) S16-2 Overview of Research and Testing in the US National Toxicology Program Nigel J Walker (NIEHS, USA) S16-3 Overview of Policy and Analysis Activities within the US National Toxicology Program Mary S Wolfe (NIEHS, USA) S16-4 New Directions in Toxicology and International Collaborations John Bucher (NIEHS, USA) S16-5 Overview of the Korea National Toxicology Program (KNTP) Jayoung Jeong (Ministry of Food and Drug Safety, Korea) The XIII 34 DAILY PROGRAM / JULY 2 (TUE) International Congress of Toxicology

S16-6 Current Status and Perspectives of Toxicogenomics in the KFDA Ho-Sang Jeong (Ministry of Food and Drug Safety, Korea) S16-7 Ongoing Nano Research on Safety in KNTP Meyoung-Kon Kim (Korea University, Korea) S16-8 Carcinogenicity Study of 3-Monochloropropane-1, 2-diol (3-MCPD) Administered by Drinking Water in SD Rats and B6C3F1 Mice Jong Kwon Lee (Ministry of Food and Drug Safety, Korea) S16-9 Efforts on Applying New Technologies to Develop Toxicity Test Methods in the KNTP for Green Growth Hyung Sik Kim (Sungkyunkwan University, Korea)

15:30 - 17:00 EO7 : EOMICS Workshop and Roundtable Discussions GBR 103 (1F) Chairs : Hitoshi Iwahashi (Gifu University, Japan) Jinhee Choi (University of Seoul, Korea) Dazhi Wang (Xiamen University, China)

* This session is organized by "Center for Multi-organ Interaction Toxicity" 15:30 - 17:00 W5 : Target Organ Toxicology and Mechanism GBR 104 (1F) Chairs : Byung-Hoon Lee (Seoul National University, Korea) Mumtaz Iscan (Ankara University, Turkey) W5-1 Double-Edged Role of AMPK in Chemical-induced Multiple Metabolic Toxicities Byung-Hoon Lee (Seoul National University, Korea) W5-2 Genomic Identiﬁ cation of Novel Pathways that Confer Resistance to Chemical-Induced Liver Injury: Validation Using Cellular and Transgenic Models Jose E Manautou (University of Connecticut, USA) W5-3 Autophagy in Liver Toxicity Jae-Sung Kim (University of Florida, USA) W5-4 Role of the Keap1/Nrf2 Pathway in Methylmercury-mediated Neurotoxicity Yoshito Kumagai (University of Tsukuba, Japan)

15:30 - 16:30 W6 : Cellular Phone and Electromagnetic Field Radiation (EFR): Current GBR 105 (1F) Status of Safety Chair : David L Mccormick (IIT Research Institute, USA) W6-1 Integration of Experimental and Epidemiologic Data into a 'Weight of the Evidence' Evaluation of Possible Risks of Exposure to Radiofrequency Fields Generated by Wireless Telephones David L Mccormick (IIT Research Institute, USA) W6-2 The Animal Studies of Combined RF-EMF Exposure Yun-Sil Lee (Ewha Womans University, Korea) W6-3 European Evaluation of EMF Health Issues: Opinions by the Independent Scientiﬁ c Committee on Emerging and Newly Identiﬁ ed Health Risks (SCENIHR) Mats-Olof Mattsson (AIT Austrian Institute of Technology, Austria)

15:30 - 16:30 RT 2 : Publishing Trends in Toxicology Room 203A (2F) Chair : Hermann M Bolt (IfADo, Germany) RT 2-1 Round Table on Toxicological Publications at ICT2010, Barcelona Alan Boobis (Imperial College London, United Kingdom) The XIII International Congress DAILY PROGRAM / JULY 2 (TUE) 35 of Toxicology

RT 2-2 Present State and Problems in the Publication of Epidemiological Data Dirk Pallapies (IPA, Germany) RT 2-3 Recent Developments Reﬂ ected by a Toxicological Journal, Toxicological Sciences Chiharu Tohyama (University of Tokyo, Japan) RT 2-4 Round Table: Publishing Trends in Toxicology Hermann M Bolt (IfADo, Germany)

15:30 - 17:30 Oral Session 1 Room 203B (2F) Chairs : Petra S Kern (Procter & Gamble, China) Bruno Megarbane (Paris-Diderot University, France) OP 1-1 Bayesian Integrated Testing Strategy to Assess Skin Sensitization Potency: From Theory to Practice Petra S Kern (Procter & Gamble Co. Ltd., China) OP 1-2 The Role of Nrf2 on Hepatic VEGFA/VEGFR Expression and Vascularization John J Skoko (Johns Hopkins University, USA) OP 1-3 Ratio of Angiopoietin-2 to Angiopoietin-1 Predicts Mortality in Acute Lung Injury Induced by Paraquat Hyo-Wook Gil (Soonchunhyang University Cheonan Hospital, Korea) OP 1-4 Alterations in the Mesolimbic Dopaminergic System and Fear Related Emotional Functions In Mice Perinatally Exposed to TCDD Seico Benner (The University of Tokyo, Japan) OP 1-5 Role of P-glycoprotein in the Development of Tolerance to the Analgesic and Respiratory Effects of Buprenorphine in Mice Bruno Megarbane (Paris-Diderot University, France) OP 1-6 DNA Methylation in Workers of Nuclear Power Plants Younghyun Lee (Seoul National University, Korea) OP 1-7 Parameters of Metabolic Syndrome in Aryl Hydrocarbon Receptor Deﬁ cient Mice Charlotte Esser (IUF, Immunotoxikology, Germany) OP 1-8 B Cell Lymphoma/ Leukemia 10 Regulated STAT1/S100P/ Axis to Promote Oral Cancer Progression Cheng-Chi Chang (National Taiwan University, Taiwan) The XIII 36 DAILY PROGRAM / JULY 3 (WED) International Congress of Toxicology

10:30 - 12:00 S17 : Recent Topics about Risk Assessment of Nanomaterials for Nano- GBR 101 (1F) Safety Science Chairs : Akihiko Hirose (National Institute of Health Sciences, Japan) Myung-Haing Cho (Seoul National University, Korea) S17-1 Understanding Key Factors that Determine the Toxicity of Nanomaterials Chunying Chen (National Center for Nanoscience and Technology, China) S17-2 The Importance of Systemic Nanotoxicological and Toxicokinetic Analysis for Ensuring the Safety of Nanomaterials Yasuo Yoshioka (Osaka University, Japan) S17-3 Zinc Oxide Nanoparticle Inducedautophagic Cell Death and Mitochondrial Damagevia ROS Generation Myung-Haing Cho (Seoul National University, Korea)

10:30 - 12:00 S18 : Complexities and Challenges in Toxicity and Treatment of GBR 102 (1F) Organophosphate Poisoning Chairs : Tetsuo Satoh (Chiba University, Japan) Ramesh C Gupta (Murray State University, USA) S18-1 An Introduction to Complexities of Organophosphate Toxicity Tetsuo Satoh (Chiba University, Japan) S18-2 Recent Developments in Toxicity and Treatment of Organophosphates Ramesh C Gupta (Murray State University, USA) S18-3 Highly Sensitive Esterases other than Cholinesterases: Potential New Targets for OPs Detected by Advanced Kinetic Approaches Eugenio Vilanova (University Miguel Hernandez of Elche, Spain) S18-4 Nerve-gas Sarin-exposed Victims in Tokyo Subways Eisasters and their Post-exposed “Indeﬁ nite Complaint” and a Proposal of Possible Therapeutic Treatment Takemi Yoshida (Council on Pharmacists Credentials, Japan) S18-5 Delayed Effects on CNS Induced by Disturbance of Neural Activity during Development - Behavioral Impairment in Male Adult Mice Induced by Postnatal Oral Intake of Acephate - Kentaro Tanemura (Tohoku University, Japan)

10:30 - 12:00 EO8 : Systems Ecotoxicology GBR 103 (1F) Chairs : Jinhee Choi (University of Seoul, Korea) James K Chipman (The University of Birmingham, United Kindom) EO8-1 P-glycoprotein-mediated Heavy Metal Tolerance in the Cd, Cu, and Zn-exposed Intertidal Copepod, Tigriopus Japonicas Jae-Seong Lee (Hanyang University, Korea) EO8-2 Aquaporin 3 Variant Expression in Killiﬁ sh (Fundulus heteroclitus): Tissue-speciﬁ city and Implications in Arsenic Uptake Dawoon Jung (Geisel School of Medicine at Dartmouth, USA) EO8-3 MWCNT Toxicity Pathway Analysis in C.elegans Carlos P Roca (Universitat Rovira i Virgili, Spain) EO8-4 Use of Toxicogenomics and Functional Genomics Tools to Develop Adverse Outcome Pathways (AOPs) in the Nematode, Caenorhabidits elegans Jinhee Choi (University of Seoul, Korea) The XIII International Congress DAILY PROGRAM / JULY 3 (WED) 37 of Toxicology

EO8-5 Dinoﬂ agellate Genomics for Understanding Marine Environmental Problems Senjie Lin (University of Connecticut, USA) EO8-6 Metabolic Physiology of Zebraﬁ sh (Danio rerio) Phenotypic Heterogeneity Response to Vibrio Parahaemolyticus Infection Chang Guo (Sun Yat-Sen University, China)

10:30 - 12:00 S19 : Application of Systems Biology for Cancer Biomarkers GBR 104 (1F) Chair : Thomas R Sutter (University of Memphis, USA) S19-1 Integration of Toxicogenomic and Metabolomic Studies to Identify Biomarkers of Human Responses to Dioxin Thomas R Sutter (University of Memphis, USA) S19-2 Lung Cancer Biomarkers: Discovery and Clinical Assay Development Je-Yoel Cho (Seoul National University, Korea) S19-3 Insulin Signaling through the PI3, AkT, mTOR Pathway in the Regulation of Gene and MicroRNA Expression in Primary Cultured Rat Hepatocytes Raymond F Novak (Shriners Hospitals for Children International, USA) S19-4 Keap1-Nrf2 System and Toxicology Masayuki Yamamoto (Tohoku University, Japan)

10:30 - 12:00 S20 : Genetics & Epigenetics - The Link Between Individual Genomes- GBR 105 (1F) Environment Interaction and Toxicity Chair : John E French (NIEHS/NTP, USA) S20-1 Population Based Mouse Model for Toxicology and Carcinogenesis John E French (NIEHS/NTP, USA) S20-2 Gestational Programming of Offspring Phenotype by Maternal Ethanol Consumption in the Mouse Suyinn Chong (Mater Medical Research Institute, Australia) S20-3 Genetic Approaches to Identifying Toxicity Pathways Tim Wiltshire (University of North Carolina, USA) S20-4 Population-Based Molding of Environmental Toxicant Co-Exposure: Linking Trichloroethylene and Inorganic Arsenic to Kidney Cancer David Threadgill (North Carolina State University, USA)

* This session is organized by KoCVAM and CAMSEC 10:30 - 12:00 W7 : Alternative Test Methods and International Regulatory Room 203 (2F) Perspectives Chairs : Soon Young Han (Korea National Institutes of Health, Korea) Warren Casey (National Institute of Environmental Health Sciences, USA) W7-1 Contributions to the Implementation of Alternative Test Methods in Korea Won Keun Seong (Ministry of Food and Drug Safety, Korea) W7-2 JaCVAM: Recent Progress and Future Plans for the Validation and Acceptance of Alternative Testing in Japan Hajime Kojima (National Institute of Health Sciences, Japan) The XIII 38 DAILY PROGRAM / JULY 3 (WED) International Congress of Toxicology

W7-3 A New Strategic Direction for ICCVAM and NICEATM, Future Plans for the Validation and Acceptance of AlternativeTest Methods in the U.S. Warren Casey (National Institute of Environmental Health Sciences, USA) W7-4 Contributions to the Implementation of Alternative Test Methods in EU and Future Plans Valerie Zuang (European Commission-Joint Research Centre, Italy) W7-5 Current Status of Development on Alternative Methods for Screening Skin Sensitizers Erwin L Roggen (3Rs Management and Consultancy, Denmark) W7-6 Current Status of Animal Alternatives for Cosmetics in Korea Kyeho Shin (AmorePaciﬁ c Corporation, Korea)

12:00 - 14:00 Lunch

14:00 - 15:30 EO9 : High-throughput Next Generation Sequencing Methods and Room 203 (2F) Applications Chairs : Leming Shi (Fudan University, China) Cesare Furlanello (FBK-Fondazione Bruno Kessler, Italy) EO9-1 Landscape of Rat Transcriptomic Body Map throughout Life Cycle Charles Wang (City of Hope National Medical Center, USA) EO9-2 The SEQC Project: Power and Limitations of RNA-Seq Leming Shi (Fudan University, China) EO9-3 Database of Transcriptional Start Sites and Epigenetic Markers for Analyzing Transcriptional Consequences of SNVs Yutaka Suzuki (University of Tokyo, Japan) EO9-4 Assessing Functional Genetic Variants by Different Approaches Baitang Ning (University of Arkansas, USA) EO9-5 Differential Networks on RNA-Seq for Toxicogenomics Cesare Furlanello (FBK-Fondazione Bruno Kessler, Italy) EO9-6 Comparative Ecotoxicogenomics Using Medaka, Daphnia and Algae Hajime Watanabe (Osaka University, Japan)

15:30 - 17:00 S21 : Toxicity of Herbs & Dietary Supplements: Global Efforts at GBR 101 (1F) Prevention Chairs : Alan D Woolf (Harvard Medical School, USA) Chen-Chang Yang (National Yang-Ming University, Taiwan) S21-1 Disease Preventive Ability as well as the Toxicity of African Herbal Remedies Vanessa Steenkamp (University of Pretoria, South Africa) S21-2 Metals & Pesticides Contaminants in Certain Herbs & Herbal Products Alan D Woolf (Harvard Medical School, USA) S21-3 The Spectrum of Herbal Poisonings Jou-Fang Deng (Taipei Veterans General Hospital, Taiwan) S21-4 Risk Management Approach to the Toxicological Problems Associated with Herbal Medicines Thomas Y Chan (The Chinese University of Hong Kong, Hong Kong) The XIII International Congress DAILY PROGRAM / JULY 3 (WED) 39 of Toxicology

15:30 - 17:00 S22 : Free Radical Toxicology GBR 102 (1F) Chairs : Myung-Hee Chung (Sungkyunkwan University, Korea) Chunxu Hai (Fourth Military Medical University, China) S22-1 Targeting Keap1-Nrf2 Signaling for Disease Prevention Thomas W Kensler (University of Pittsburgh, USA) S22-2 The Therapeutic Potential of a ROS-induced Modiﬁ ed Guanine Nucleoside, 8-Oxo-deoxyguanosine as a Rac Inhibition Myung-Hee Chung (Sungkyunkwan University, Korea) S22-3 Breakthrough in Mechanism and Preventive Strategy of Acute Lung Injury Induced by Phosgene Chunxu Hai (Fourth Military Medical University, China) S22-4 Oxidative Stress and Biological Effects of Extremely Low Frequency Magnetic Fields Mats-Olof Mattsson (AIT Austrian Institute of Technology, Austria)

15:30 - 17:00 EO10 : Environmental Exposure and Toxicity, an Integrated OMICS GBR 103 (1F) Approach Chairs : Baitang Ning (University of Arkansas for Medical Sciences, USA) Hui Li (Sun Yat-Sen University, China) EO10-1 Integration among in Vitro and in Vivo for the Evaluation of Radiation Effect using Genomics Junko Takahashi (AIST, Japan) EO10-2 Circulating MicroRNA Profi les Altered in Mice after 28 Days Exposed to Perfl uorooctanoic Acid Young Rok Seo (Dongguk University, Korea) EO10-3 Exploration and Clinical Application of Cancer Genome Biomarkers at NCC Japan Katsuya Tsuchihara (National Cancer Center, Japan) EO10-4 Absence of Mature miRNAs Inactivates the Response of Gene Expression to Carcinogenesis induced by N-ethyl-N-nitrosourea in Mouse Liver Yang Luan (Shanghai Institute of Materia Medica, China) EO10-5 Marine Metaproteomics: Current Status and Future Directions Da-Zhi Wang (Xiamen University, China) EO10-6 Quantitative/qualitative Metabolic Regulation for Double Increasing Balofl oxacin Concentrations in Vibrio Alginolyticus Manjun Yang (Tibert Vocational Technical College, China)

15:30 - 17:00 EO11: Human Microbiome and Microbial OMICS GBR 104 (1F) Chairs : Xuanxian Peng (Sun Yat-Sen University, China) Joonhong Park (Yonsei University, Korea) EO11-1 Enviromics Analysis of Biological Process in Rice Rhizosphere Mediated by Nitrogen Fertilizer Wenxiong Lin (Fujian Agriculture and Forestry University, China) EO11-2 Proteomics Approach for Understanding of Antibiotic Resistance Xuanxian Peng (Sun Yat-sen University, China) EO11-3 An Association between Helicobacter and Human Gastric Microbiome Diversity in Gastric Cancer Patients in Korea Joonhong Park (Yonsei University, Korea) EO11-4 Metabolic Regulation of Antibiotic Resistance in Escherichia Coli based on Metabolomic Analysis Xianliang Zhao (Sun Yat-Sen University, China) The XIII 40 DAILY PROGRAM / JULY 3 (WED) International Congress of Toxicology

EO11-5 The Effects of Rehmannia Glutinosa Consecutive Monoculture on Microecology in Rhizosphere by Metagenomics and Metaproteomics Linkun Wu (Fujian Agricultural and Forestry University, China) EO11-6 Proteomic Proﬁ ling of Acute Arsenic Toxicity to Adult Zebraﬁ sh Liver Caixia Li (National University of Singapore, Singapore)

15:30 - 17:00 S23 : New Risk Assessment of Airborne Materials and Health GBR 105 (1F) Technologies in Respiratory System Chairs : Seishiro Hirano (National Institute for Environmental Studies, Japan) Yong Chul Lee (Chonbuk National University, Korea) S23-1 Replacing Animal Inhalation Studies Designed for Human Risk Assessments with in Vitro Technologies: How Close Are We? Scott E Loveless (DuPont Haskell Global Centers, USA) S23-2 The Organelle-complex Targeting Health Technology in Respiratory System: Mitochondria and ER in Pulmonary Disorders Yong Chul Lee (Chonbuk National University, Korea) S23-3 Safety and Proof-of-Concept Eﬃ cacy of Inhaled Drug loaded Nano- and Immunonanoparticles in a c-Raf Transgenic Lung Cancer Model Juergen Borlak (Hannover Medical School, Germany) S23-4 A Role of Macrophage Receptor with Collagenous Structure (MARCO) in Cellular Uptake of Particulate Substances Seishiro Hirano (National Institute for Environmental Studies, Japan)

15:30 - 17:30 Oral Session 2 Room 203A (2F) Chairs : Eva Cecilie Bonefeld-Jorgensen (Unversity of Aarhus, Denmark) Chan Young Shin (Konkuk University, Korea) OP 2-1 Breast Cancer Risk in Danish Women: A Case-Control Study on the Risk of Breast Cancer upon Exposure to Perﬂ uorinated Compounds Eva Cecilie Bonefeld-Jorgensen (Unversity of Aarhus, Denmark) OP 2-2 Chronic Ethanol Exposure to Male Mice before Mating Produces ADHD-like Phenotype along with Epigenetic Dysregulation of Dopamine Transporter Expression in Mice Offspring Chang Soon Choi (Konkuk University, Korea) OP 2-3 Neurospheres as a Predictive 3D in Vitro Model for DNT Testing and Pathway Investigation in a Species-Speciﬁ c Context Jenny Baumann (Leibniz Research Institute for Environmental Medicine, Germany) OP 2-4 Application of Percellome Toxicogenomics Approach to Food Safety: a Flavor, Estragole Appears to be a PPAR-alpha Agonist Satoshi Kitajima (National Institute of Health Sciences, Japan) OP 2-5 Epigenetic Alterations in Leukemia: a Target for DNA Demethylating Drugs Michael Schnekenburger (Laboratoire de Biologie Moleculaire et Cellulaire du Cancer, Luxembourg) OP 2-6 Protective Effects of Sodium Benzoate on Behavioral Neurotoxicity Induced by Methamphetamine in Mice Ming-Huan Chan (National Chengchi University, Taiwan) OP 2-7 Oxidized Casein Induces Liver Injury in Mice Via Destruction of Antioxidant Defense System Zhu Qing Li (Jiangnan University, China) The XIII International Congress DAILY PROGRAM / JULY 3 (WED) 41 of Toxicology

OP 2-8 Zebraﬁ sh: a Predictive Model for Assessing Compound Toxicity, Safety and Eﬃ cacy Li Chunqi (Hunter Biotechnology, Inc., China)

15:30 - 17:30 Oral Session 3 Room 203B (2F) Chairs : Jonghan Kim (Northeastern University, USA) Sepideh Arbabi Bidgoli (Islamic Azad University, Iran) OP 3-1 Food Borne Acrylamide Exposure has Negligible Colon Cancer Risk in Two Rodent Models of Colon Tumorigenesis without Altering Tumor Suppressor Gene Promoter Methylation Status or Cancer Gene Expression Jayadev Raju (Health Canada, Canada) OP 3-2 A Basic Study on the Association Between Nanomaterials and Brain Disorder: Distribution of Silver Nanoparticles into Brain Kota Tanaka (Osaka University, Japan) OP 3-3 The Role of IL1-B Gene on the Infl ammatory and Genotoxic Effects of Multi-Walled Carbon Nanotubes Shan Zienolddiny (National Institute of Occupational Health, Norway) OP 3-4 Suppression of Toll-like Receptor 4 Activation by Caffeic Acid Phenethyl Ester is Mediated by Modifi cation of Cys133 in MD2 Jung-Eun Koo (The Catholic University of Korea, Korea) OP 3-5 Aryl Hydrocarbon Receptor Repressor (AHRR) Function Revisited: Repression of CYP1 Activity in Human Skin Fibroblasts is not Related to AHRR Expression Ellen Fritsche (IUF-Leibniz Institute for Environmental Research, Germany) OP 3-6 Infl uence of Altered Iron Metabolism on Olfactory Transport and Neurotoxicity of Manganese Jonghan Kim (Northeastern University, USA) OP 3-7 AhR Levels in Male and Female Environmental Induced Reproductive Tumors: Association with Hormonal and Nutritional Factors Sepideh Arbabi Bidgoli (Islamic Azad University, Iran) OP 3-8 Metabonomic Analysis of the Metabolic Effects of Methotrexate and the Effect of NASH on Methotrexate Metabolism and Hepatotoxicity Michael Kyriakides (Imperial College London, United Kingdom)

18:00 - 20:00 Gala Dinner Harmony Ballroom, COEX Intercontinental Hotel (B1) The XIII 42 DAILY PROGRAM / JULY 4 (THU) International Congress of Toxicology

10:30 - 12:00 S24 : Environmental Burden of Disease: How to Assess and Prioritize GBR 101 (1F) Actions Chairs : Andrew Dawson (Royal Prince Alfred Hospital, Australia) Carolyn Vickers (World Health Organization, Switzerland) S24-1 Burden of Disease due to Chemicals: Symposium Introductory Overview Carolyn Vickers (World Health Organization, Switzerland) S24-2 Lead: Multiple Impacts, Multiple Sources of Exposure, Key Intervention Strategies Byung-Kook Lee (Soonchunhyang University College of Medicine, Korea) S24-3 Focusing Public Health and Occupational Intervention Strategies for Mercury Keri G Fulcher (Tetra Tech Sciences, USA) S24-4 Pesticides: a Spectrum of Risk Andrew Dawson (Royal Prince Alfred Hospital, Australia)

10:30 - 12:00 S25 : Korean Ginseng: Eﬃ cacy and Safety GBR 102 (1F) Chairs : Jaejoon Wee (KGC, Korea) Mark Blumenthal (American Botanical Council, USA) S25-1 Safety of Korean Red Ginseng Young J Lee (LSK Global Pharma Services, Korea) S25-2 Unusual Frequent Genetic Defects in HIV-1 Infected Long-term Survivors for 25 Years in the Absence of Antiretroviral Therapy: Its Association with Korean Red Ginseng Intake Young-Keol Cho (University of Ulsan College of Medicine, Korea) S25-3 Suppression of Carcinoma Growth and Molecular Targets of the Ethanol Extracts of Panax Ginseng Liang Liu (Macau University of Science and Technology, China) S25-4 A Brief Review of the Safety and Eﬃ cacy of Asian Red Ginseng Root Mark Blumenthal (American Botanical Council, USA)

10:30 - 12:00 W8 : Safety Evaluation for Biosimilar and Drug Development GBR 103 (1F) Chair : Jeehyeon Bae (Chung-Ang University, Korea) W8-1 Preclinical Testing of Biosimilars Lawrence Jacob (Charles River, United Kingdom) W8-2 Regulatory Framework on Preclinical testing of Biopharmaceuticals in Korea - Focus on Biosimilar Kyung-Min Baek (Ministry of Food and Drug Safety, Korea)

10:30 - 12:00 S26 : Active Metabolites: Potential Target for New Drug Discovery and GBR 104 (1F) Toxicity Chairs : Allan E Rettie (University of Washington, USA) Dafang Zhong (Chinese Academy of Sciences, China) S26-1 The Role of Reactive Metabolite Formation in Adverse Drug Reactions Dominic Williams (The University of Liverpool, United Kingdom) S26-2 Mechanisms of Drug-Drug Interactions Involving Amiodarone Metabolites: Roles of Reversible and Time-Dependent Inhibition Allan E Rettie (University of Washington, USA) S26-3 Metabolic Bioactivation Potentially Related to Toxicities of some Herbal Drug Components Dafang Zhong (Chinese Academy of Sciences, China) The XIII International Congress DAILY PROGRAM / JULY 4 (THU) 43 of Toxicology

S26-4 Genetic Factors Affecting Metabolism to Reactive Intermediates in Idiosyncratic Hepatotoxicity Ann K Daly (Newcastle University, United Kingdom)

10:30 - 12:00 S27 : The Evidence-Based Toxicology Collaboration GBR 105 (1F) Chairs : Sebastian Hoffmann (Seh consulting + Services, Germany) Ian Kimber (University of Manchester, United Kingdom) S27-1 Evidence Based Toxicology: Background and Purpose Ian Kimber (University of Manchester, United Kingdom) S27-2 The Evidence-based Toxicology Collaboration Thomas Hartung (Johns Hopkins University, USA) S27-3 The EBTC’s Focus on Evidence-Based Methods Sebastian Hoffmann (Seh Consulting + Services, Germany) S27-4 EBT - The Toolbox for Assessment of Tests and Testing Strategies Thomas Hartung (Johns Hopkins University, USA)

12:00 - 12:30 Closing Ceremony GBR 103 (1F)

POSTER SESSION

July 1 July 2 July 3 The XIII 46 POSTER International Congress of Toxicology

July 1 (Mon) - 3 (Wed), 3 Days / 13:00 ~ 14:00, Hall B2 (1F) July 1 (Mon) P1-001 ~ 025 Alternative Methods to Animal Testing P1-174 ~ 206 Cellular Effects of Natural Products P1-026 ~ 049 Animal Models in Toxicology P1-207 ~ 228 Chemoprevention P1-050 ~ 071 Apoptosis P1-229 ~ 231 Climate Change and Human Health P1-072 ~ 075 Autophagy P1-232 ~ 250 Clinical Toxicology P1-076 ~ 102 Biomarkers P1-251 ~ 254 Computational Toxicology P1-103 ~ 119 Biomonitoring P1-255 ~ 259 Cosmetics and Safety P1-120 ~ 139 Carcinogenesis P1-260 ~ 286 Development and Reproductive Toxicology P1-140 ~ 148 Cardiotoxicity P1-287 ~ 291 DNA Replication and Repair P1-149 ~ 173 Cell Signaling and Gene Expression P1-292 ~ 314 Drug Induced Toxicity

July 2 (Tue) P2-001 ~ 015 Drug Metabolizing Enzymes P2-154 ~ 164 Genetic Polymorphisms P2-016~ 038 Ecotoxicology P2-165 ~ 189 Genotoxicity P2-039 ~ 055 Endocrine Disrupting Chemicals P2-190 ~ 216 Hepatotoxicity P2-056 ~ 060 Environmental Mutagens P2-217 ~ 239 Immunotoxicity P2-061 ~ 086 Epidermiology and Exposure P2-240 ~ 254 Industrial Toxicity Assessment P2-255 ~ 269 Inﬂ ammation P2-087 ~ 100 Epigenetic Regulation P2-270 ~ 289 Inhalation and Pulmonary Toxicology P2-101 ~ 153 Food Safety P2-290 ~ 334 Metal Toxicity

July 3 (Wed) P3-001 ~ 051 Nanotoxicology P3-169 ~ 201 Risk Assessment P3-052 ~ 058 Nephrotoxicity P3-202 ~ 206 Skin Toxicity P3-059 ~ 097 Neurotoxicity P3-207 ~ 216 Stem Cell Toxicology P3-098 ~ 106 Omics in Toxicology P3-217 ~ 225 Systems Toxicology (Genomics, P3-107 ~ 109 Others Proteomics, Metabolomics) P3-110 ~ 135 Oxidative Stress and Redox Toxicity P3-226 ~ 257 Toxicity Testing P3-136 ~ 157 Pesticides P3-258 ~ 275 Toxicokinetics and Toxicodynamics P3-158 ~ 161 Radiation P3-276 ~ 287 Late Breaking Abstracts P3-162 ~ 168 Receptor Mediated Toxicity

ICEO Poster July 3 (Wed) EO-P01 ~ 06 Environmental Exposure and Toxicity, an Integrated OMICS Approach EO-P07 Environmenta Genomics EO-P08 Genotoxicity EO-P09 High-throughput Next Generation Sequencing Methods and Applications EO-P10~ 14 Human Microbiome and Microbial OMICS EO-P15 ~ 20 Mechanisms of Toxicity: Genomics-based and Mechanism-based Biomarkers EO-P21 ~ 35 Molecular and Cellular Toxicity Mechanisms and Adverse Health Outcomes EO-P36 OMICS Data, Bioinformatics and Mathematic Modeling EO-P37 ~ 39 Protein Responses to Environmental Exposures EO-P40 ~ 44 Systems Ecotoxicology EO-P45 Late Breaking Abstract The XIII International Congress POSTER / JULY 1 (MON) 47 of Toxicology

P1-001 ~ 025 : Alternative Methods to Animal Testing P1-001 Nerve-cell Mimicking Liposomes as in Vitro Alternative to Potency-testing of Toxins with Multistep Pathways - the Case of Botulinum Neurotoxin Oliver G Weingart1, Frank Gessler2, Andreas Rummel3, Marc A Avondet4 and Martin J Loessner1 1 ETH Zurich, Switzerland, 2 Miprolab GmbH, Germany, 3 Institute for Toxicology, MH Hannover, Germany, 4 Labor Spiez, Switzerland P1-002 Using QSAR Modeling to Predict Developmental Toxicity Evisabel A Craig, Nina Wang and Q. J Zhao US EPA, USA P1-003 Sequential Testing Strategy Proposed for Eye Irritation Assessment of Hair Dyes Yang Ying1, Yang X Fen1, Zhang X Wengai1, John Harbell2, Rodger Curren3 and Xiong Xikun1 1 Guangdong Provincial Center for Disease Control and Prevention, China, 2 Mary KAY inc, USA, 3 IIVS, USA P1-004 A Progressive Eye Irritation Testing Strategies for Application of Eye Irritation Alternative Methods on Cosmetic Ingredients Yang Ying1, Yang Xingfen1*, Xue Jinyu1, Rodger Curren2, Huang Junming1 and Xie Xiaoping1 1 GDCDC, China, 2 IIVS, USA P1-005 The Evidence-based Toxicology Collaboration Sebastian Hoffmann1* and Martin Stephens2 1 Seh Consulting + Services, Germany, 2 Johns Hopkins University, USA P1-006 Predictive Performance of Human Cell Line Activation Test (h-CLAT) for Skin Sensitizing Potential of Lipophilic Chemicals Osamu Takenouchi1, Kazutoshi Saito1, Masaaki Miyazawa1, Takao Ashikaga2 and Hitoshi Sakaguchi1* 1 Kao Corporation, Japan, 2 Shiseido Corporation, Japan P1-007 Development of a PBPK Model for TiO2 Nanoparticles Gerald Bachler*, Natalie Von Goetz and Konrad Hungerbuhler Institute for Chemical and Bioengineering, ETH Zurich, Switzerland P1-008 Study of Toxic Mechanisms Induced by Benzo[a]pyrene (BaP) on a Human Placental Cell Model Anais Wakx*, Laetitia Fernandes, Olivier Laprevote and Patrice Rat Universite Paris Descartes, France P1-009 Genotoxicity of Benzene and its Hydroxylated Metabolites in V79-hCYP2E1-hSULT1A1 Cells Yungang Liu1 and Hansruedi Glatt2 1 Southern Medical University, China, 2 German Institute of Human Nutrition, Germany P1-010 New Detecting Method for Estimating the Eye Irritation Potential of Chemicals: An Alternative to the Draize Test Sun-A Cho, Ji Hoon Kim, Ji-Yei Choi, Jun-Cheol Cho and Kyeho Shin* AmorePacifi c Corporation R&D Unit, Korea P1-011 Anti-allergic Effect of Plant Extract on Aromatic Amine Hair Dye Precursors and Its Evaluation by in Vitro Alternative Method on the Basis of Dendritic Cell Differentiation Model Ji Hoon Kim, Sun-A Cho, Ji-Yei Choi, Jun-Cheol Cho, Jonghyub Kim, Jaejung Park, Wang-Gi Kim and Kyeho Shin* AmorePacifi c Corporation R&D Unit, Korea P1-012 Validation of Local Lymph Node Assay; BrdU-fl ow Cytometry Method for Skin Sensitization Alternatives Kyeong Uk Yeo1, Kyung Mi Jung2, Tae Won Jeon3, Won Hee Jang2, Mee Young Park2, Kyung Min Lim2, Mi Sook Jung3, Eun Young Jeon3, Ji Hoon Jo1 and Yong Heo1* 1 Catholic University of Daegu, Korea, 2Amorepacifi c Co. R&D Center, Korea, 3 Biotoxtech Co., Korea P1-013 Validation of Human Epidermal Model Keraskin™-VM for Skin Irritation Alternative Method Seung Hyeok Seok1, Kyung Mi Jung2, Kyeong Uk Yeo3, Jeong Hwan Che4, Kyung Min Lim2, Won Hee Jang2, Mee Young Park2, Yun Soon Kim4, Dain Son1, Su Hyon Lee5 and Yong Heo3* 1 Seoul National University, Korea, 2 Amorepacifi c Co. R&D Center, Korea, 3 Catholic University of Daegu, Korea, 4 Seoul National University Hospital Biomedical Research Institute, Korea, 5 Modern Cell & Tissue Technologies (MCTT) Co., Korea The XIII 48 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-014 Transcriptional Profi ling Studies of Cosmetic Ingredients in Human Keratinocytes to Discover Novel Biomarkers for Alternative Skin Toxicity Tests Sun Hee Jin1, Mi Hwa Han1, Soo Hyun Hong1, Ok-Nam Bae2, Ai-Young Lee3 and Minsoo Noh1 1 Ajou University, Korea, 2 Hanyang University, Korea, 3 Dongguk University School of Medicine, Korea P1-015 Evaluation of Local Lymph Node Assay as an Alternative Method for Skin Sensitization Potential of Chemicals in Balb/c Mice Mi Sook Jung1, Eun Young Jeon1, Heung Mo Bae1, Tae Won Jeon1, Sang Koo Lee1 and Jong Koo Kang2* 1 Biotoxtech Co., Ltd., Korea, 2 Biotoxtech Co., Ltd. & Chung-buk National University, Korea P1-016 Pre-validation Study of Non-radioactive Local Lymph Node Assay; LLNA:BrdU-FCM Won-Hee Jang1, Kyoung-Mi Jung1, Yong Heo2, Tae Won Jeon3, Mi Sook Jung3, Eun Young Jeon3, Kyeong Uk Yeo2, Miyoung Park1 and Kyung-Min Lim4* 1 Amorepacifi c R&D Center, Korea, 2 Catholic University of Daegu, Korea, 3 Biotoxtech Co., Korea, 4 Ewha Womans’ University, Korea P1-017 Development of Transporter Screening System for the Identifi cation of Transporter-Mediated Drug- Drug Interaction in Early Phase of Drug Discovery Chi-Kyoung Noh1, Jae-Il Lee1, So-Jung Jung1, Hyo-Kyung Han2 and Suk-Jae Chung1* 1 Seoul National University, Korea, 2 Dongguk University, Korea P1-018 Estimation of Ajoene Toxicity and Metabolism with 3D Cellular Microarray Mihi Yang* Sookmyung Women's University, Korea P1-019 Modulation of Antioxidant Response Element in JB6 Cell by Phototoxic Substances Yong Kyoung Lee, Mi Hyang Nam, Chea Hyung Lim, Jun Young Yang, Il Young Ahn, Soon Young Han and Ki Hwan Choi* National Institute of Food and Drug Safety Evaluation, Korea P1-020 Reconstituted Human Skin (Neoderm®) to Substitute Animal Testing for Toxicity and Effi cacy Test of Drugs or Cosmetic Ingredients Yun Hee Kim, Eun-Jung Oh, Eun-Joo Kim and Seawha Jeon* Cutigen Research Institute, Tego Science Inc., Korea

P1-021 Effect of New Charcoal Filter on the in Vitro Pulmonary Toxicity of Cigarette Mainstream Smoke Han-Jae Shin KT&G Research Institute, Korea P1-022 Evaluating the Micronucleus Induction Potential for the Genotoxicity Assay using the KeraSkin™ Human Skin Model Su Hyon Lee and Haeng Sun Jung R&D Institute, Modern Cell & Tissue Technologies, Inc.,, Korea P1-023 Evaluation of an Alternative to Skin Irritation Testing using the Reconstructed Human Epidermis Model KeraSkinTM-VM; Results of the Intralaboratory Validation Study Kyoungmi Jung1, Su-Hyon Lee2, Won-Hee Jang1, Miyoung Park1, Yong Heo3, Young-Ho Park1, Kyung-Min Lim4* and Seung Hyeok Seok5* 1 Amorepaciﬁ c Co. R&D Center, Korea, 2 Modern Cell & Tissue Technologies Inc., Korea, 3 Catholic University of Daegu, Korea, 4 Ewha Womans University, Korea, 5 Seoul National University, Korea P1-024 Activities of Korean Center for the Validation of Alternative Methods (KoCVAM) for Strength Alternative Test Method in Korea Yong Kyoung Lee, Chea Hyung Lim, Jun Young Yang, Il Young Ahn, Soon Young Han and Ki Hwan Choi* National Institute of Food and Drug Safety Evaluation, Korea P1-025 Redox-sensitive Signaling Pathway is Upregulated in Response to Skin Sensitizers in Human Keratinocyte Yong Kyoung Lee, Chea Hyung Lim, Jun Young Yang, Il Young Ahn, Soon Young Han and Ki Hwan Choi* National Institute of Food and Drug Safety Evaluation, Korea The XIII International Congress POSTER / JULY 1 (MON) 49 of Toxicology

P1-026 ~ 049 : Alternative Methods to Animal Testing P1-026 IL-4 and IL-5 Secretions Predominate in the Airways of Wistar Rats Exposed to Toluene Disocyanate Vapor Kouame Kouadio Institut Pasteur of Cote d'Ivoire, Ivory Coast P1-027 Sequencing and Molecular Identifi cation of a cDNA Coding for Beta Neurotoxin Potassium Channel Inhibitor from the Venom Glands Scorpion Mesobuthus Eupeus Ghafar Eskandari1, Abbas Jolodar2 and Ardeshir Bahmanimehr3 1 Payame Noor University, Iran, 2 Shahid Chaamran Uiversity of Ahvaz, Iran, 3 National Academy of Sciences of Armeni, Iran P1-028 Quantum Mechanical, in Vitro and in Vivo Evidence of the Involvement of Non-bonding Nitrogen Interactions in Valine Derived β- amino Chalcogenides Waseem Hassan, Senthil Narayanaperumal, Kashif Gul, Rogerio De Aquino Saraiva, Antonio L Braga, Oscar E Rodrigues and Joao B Da Rocha Universidade Federal de Santa Maria, Brazil P1-029 Thioacetamide Activate Mast Cell Congregate in Pericardial Sac and Induce Heart Failure-like Syndrome during Zebrafi sh Development Ya-Ging Liu, Po-Rung Jiang, Chia-Jung Wang and Chuian-Fu Ken* Institute of Biotechnology, National Changhua University of Education, Taiwan P1-030 Vitamin E Modulates Sensorimotor and Cognitive Changes Induced by Chronic Chlorpyrifos Exposure in Wistar Rats Suleiman F Ambali1*, Joseph O Ayo2, Muftau Shittu2, Olushola O Oladipo3 and Abdul-Ganiyu Ambali1 1 University of Ilorin, Nigeria, 2 Ahmadu Bello University, Nigeria, 3 National Veterinary Research Institute, Nigeria P1-031 Lipopolysaccharide-activatied Microglia Induced Neurodegenerative Animal Model such as Parkinson’s Disease and Dementia Sachiko Tanaka, Takemi Yoshida, Takashi Ashino and Satoshi Numazawa Showa University, Japan P1-032 A Scientifi c Approach to Selecting Diets for Toxicology Graham Tobin* Harlan Laboratories, United Kingdom P1-033 Benchmark Dose Models for Benzene Genotoxicity using the Diversity Outbred Mouse John E French1, Kristine Witt1, Grace E Kissling2, Dan L Morgan1, Daniel Gatti3 and Gary A Churchill3 1 NIEHS/NTP, USA, 2 NIEHS/NIH, USA, 3 The Jackson Laboratory, USA P1-034 Xenopus Laevis as a Tool in Drug Discovery and Development Adam Hendry1, Duncan Armstrong2, Rob Field3 and Grant Wheeler1 1 University of East Anglia, United Kingdom, 2 Astrazeneca, United Kingdom, 3 John Innes Centre, United Kingdom P1-035 Validation of Parapharyngeal Hypophysectomize Rat Model for Toxicological Studies Aekkarin Klinkhamhom, Aunchalee Sirimontaporn, Ornuma Singha, Taweesak Ketjareon, Yaowaluk Panavechkijkul, Kanchana Kengkoom and Sumate Ampawong* Mahidol University, Thailand P1-036 Systems Toxicology Approaches Enable Mechanistic Comparison of Cigarette Smoke-induced and Spontaneous Lung Tumors in the A/J Mouse Model Anita Iskandar*, Yang Xiang, Alain Sewer, Karsta Luettich, Florian Martin, Marja Talikka, Walter Schlage, Emilija Veljkovic, Ignacio Gonzalez-suarez, Julia Hoeng and Manuel Peitsch Philip Morris Research and Development, Switzerland P1-037 Appropriate Initiation Dose On 2-Step Skin Carcinogenicity Evaluation Using RasH2 Mice Koji Urano1, Mayuko Suguro2, Takamasa Numano2, Mayumi Kawabe2, Fumio Furukawa2 and Hideki Tsutsumi1* 1 Central Institute for Experimental Animals, Japan, 2 DIMS Institute of Medical Science, Inc., Japan P1-038 A Mechanistic Study of Cigarette Smoke-induced COPD and Cessation Effects in C57BL/6 Mice Blaine Phillips1, Emilija Veljkovic2*, Michael Peck2, Ansgar Buettner3, Julia Hoeng2, Gregory Vuillaume2 and Manuel Peitsch2 1 Philip Morris International, Singapore, 2 Philip Morris International, Switzerland, 3 Hiatovia, GmbH, Germany The XIII 50 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-039 Metabolic Effects of Sub-chronic Ambient Particulate Matter Inhalation Exposure in Sprague-dawley Rats Karen T Cheng1, Ching-Yu Lin1, Charles C.K. Chou2 and Tsun-Jen Cheng1* 1 National Taiwan University, Taiwan, 2 Research Center for Environmental Changes, Academia Sinica, Taiwan P1-040 Cyp1a Reporter Zebrafi sh Reveals Target Tissues for Dioxin Hua Cai1, Hong-Jae Chae1, Kun-Hee Kim1, Hyon Choy1, Xiande Liu2 and Seok-Yong Choi1* 1 Chonnam National University, Korea, 2 Hainan University, China P1-041 Observation for Mice Exposed HCN Gases from Fire Eunha Oh1*, Kyong-Sok Shin1, Jonghyeon Choi1, Yun Kyung Chung2 and Nam-Wook Cho3 1 Neodin Medical Institute, Korea, 2 Hallym University Sacred Heart Hospitial, Korea, 3 Korea Institute of Construction Technology(KICT), Korea P1-042 Inhibitory Effect of Cultivated Ginseng in the Development of 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis in NC/Nga Mice and TNF-α/IFN-γ-induced TARC Activation in HaCaT Cells Jae Ho Choi1, Sun Woo Jin1, Bong Hwan Park1, Jun Min Choi2, Young Chul Chung2 and Hye Gwang Jeong1* 1 Chungnam National University, Korea, 2 International University of Korea, Korea P1-043 Inhibitory Effect of Platycodi Radix in the Development of Dimethylnitrosamine-induced Liver Fibrosis in Rats Jae Ho Choi1, Sun Woo Jin1, Yong Pil Hwang2, Chul Yung Choi3, Young Chul Chung2, Young Chun Lee4 and Hye Gwang Jeong1* 1 Chungnam National University, Korea, 2 International University of Korea, Korea, 3 Natural Resources Research Institute, Korea, 4 Jangsaeng Doraji Co., Ltd., Korea P1-044 Inhibitory Effects of Saponins Isolated from the Root of Platycodon Grandifl orum on Ovalbumin- sensitized Mouse Allergic Asthma Model Jae Ho Choi1, Sun Woo Jin1, Hyung Gyun Kim1, Young Chul Chung2, Young Chun Lee3 and Hye Gwang Jeong1* 1 Chungnam National University, Korea, 2 International University of Korea, Korea, 3 Jangsaeng Doraji Co., Ltd., Korea P1-045 Protective Effects of Diallyl Disulfi de on Carbon Tetrachloride-induced Hepatotoxicity and Oxidative Stress in Rats Sung-Hwan Kim1, In-Chul Lee1, Hyung-Seon Baek1, Won-Kee Yun2, Ki-Hoan Nam2, Hyoung-Chin Kim2 and Jong-Choon Kim1* 1 Chonnam National University, Korea, 2 Korea Research Institute of Bioscience and Biotechnology, Korea P1-046 In Vivo Imaging of Toxicity using a Photogenic Rat Dongkyu Kim, Woo-Sung Choi, Taekwan Lee, Dae-Yong Han, Joon-Suk Park, Ha-Young Jang, Sang Kyoon Kim, Seonggon Kim, Min-Su Seo, Sanghyun Ahn and Choong-Yong Kim* Daegu-Gyeongbuk Medical Innovation Foundation, Korea P1-047 Repeated Dose Oral Toxicity Study of Aqueous Extracts of Several Medicinal Herbs in Rats Hang Sik Roh, Ji Hyeon Seok, Hye Kyung Choi, Ji Hyun Yoon, Tae Sung Kim, Young Hee Jo, Jong Kwon Lee, Soon Young Han and Ja Young Jeong* Ministry of Food and Drug Safety, Korea P1-048 Mechanisms of Protection against Cyclophosphamide Urotoxicity in Rats Treated by Diallyl Disulfi de Sung-Hwan Kim1, In-Chul Lee1, Hyung-Seon Baek1, Changjong Moon1, Sung-Ho Kim1, Hyoung-Chin Kim2 and Jong-Choon Kim1* 1 Chonnam National University, Korea, 2 Korea Research Institute of Bioscience and Biotechnology, Korea P1-049 Quantitation of Tumor Growth Rates in Solid Tumor Xenograft Experiments Ji Young Lee, Youn Kyoung Jeong and Mi-Sook Kim* Korea Institute of Radiological and Medical Sciences, Korea

P1-050 ~ 071 : Apoptosis P1-050 Apoptosis Induced by Highly Pathogenic Avian Inﬂ uenza a Virus H5N1 NS1 Protein and the Intrinsic Pathway Activation Qian Bian and Baoli Zhu* Jiangsu Province Center of Disease Control and Prevention, China

P1-051 Cellular Proliferation, Apoptosis and Angiogenic Studies of Moderately Polar Fraction of Essential Oil of Myristica Fragrans Roziahanim B Mahmud* and Suthagar P Piaru Universiti Sains Malaysia, Malaysia The XIII International Congress POSTER / JULY 1 (MON) 51 of Toxicology

P1-052 Effects of Endoplasmic Reticulum Stress on the Apoptosis Induced by Olaquindox in HK-2 Cell Bin Li National Institute of Occupational Health and Poison Control, China CDC, China P1-053 Increase in Mitochondrial Biogenesis Associated with Antioxidant Protection against Arsenic-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells Pronrumpa Ngamsiri, Piyajit Watcharasit* and Jutamaad Satayavivad* Chulabhorn Graduate Institute, Thailand P1-054 The Protective Effect of Aliskiren Treatment on Myocardial Infarction by the Decreased Apoptosis of Cardiomyocytes Bo-Jhih Pan, Ming-Hsien Chiang, Chan-Jung Liang, Wen-Ping Chen and Yuh-Lien Chen* National Taiwan University, Taiwan P1-055 Induction of G1 Cell Cycle Arrest and Apoptosis in Human Leukemic T Cells by Terrein, a Secondary Metabolite Isolated from Aspergillus Terreus Sakdiphong Punpai1, Nudjaree Tanjapatkul1, Faongchat Jarintanan2, Suchada Jongrungruangchok2 and Wanlaya Uthaisang- Tanechpongtamb1* 1 Srinakharinwirot University, Thailand, 2 Rangsit University, Thailand P1-056 Triﬂ uoromethoxy-goniothalamin Induces Caspase-2-mediated Apoptosis in K562 Chronic Myeloid Leukemia Cells through BCR-ABL Inhibition and p38 MAPK Activation Kok Meng Chan1*, Kok Lun Pang1, Weber Jean-Frederic Faizal2 and Salmaan Hussain Inayat-Hussain1 1 Faculty of Health Sciences, Malaysia, 2 Universiti Teknologi Mara, Malaysia P1-057 Newcastle Disease Virus Induces Increased Apoptosis in Hypoxic Cancer Cells Independent of their HIF- 2alpha Levels Norazizah Shafee, Wei-Choong Ch'ng and Khatijah Yusoff Universiti Putra Malaysia, Malaysia P1-058 Amphetamines, Individually and Combined, Induce Necrosis and Apoptosis to Liver Cells Depending on Temperature and Time of Exposure Diana Dias Da Silva1*, Helena Carmo1 and Elisabete Silva2 1 University of Porto, Portugal, 2 Brunel University, United Kingdom P1-059 Novel Diterpene Derivative Induced Apoptosis in Human MCF-7 Breast Cancer Cells via Targeting p53 and JNK Signaling Ahmed Malki1* and Stephen Bergmeier2 1 Alexandria University, Egypt, 2 Ohio University, USA P1-060 Cadmium Sulﬁ de Quantum Dots induce Apoptosis and Reactive Oxygen Species Formation in Embryo Hepatocyte Cells Zhang Jingshu1, Bai Shanshan2, Wang Chunhua2 and Wang Yuqiu2* 1 Tianjin Centers for Disease Control and Prevention, China, 2 Nankai University, China P1-061 The Effects of Piroxicam and Deracoxib on Canine Mammary Tumour Cell Line Fulya Ustun Alkan*, Oya Ustuner, Tulay Bakırel, Suzan Cınar, Gaye Erten and Gunnur Deniz Istanbul University, Turkey P1-062 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Induces Microglial Nitric Oxide Production and Subsequent Rat Primary Cortical Neuron Apoptosis through p38/JNK MAPK Pathway Yuanye Li, Chunhua Wu, Xiaoke Nie, Jianya Zhao, Jiao Liu, Zhiqing Duan, Guangfei Xu, Chenjuan Yao and Gang Chen* Nantong University, China P1-063 Curcumin Synergistically Enhances Anti-proliferative Activity of Cyclophosphamide in Canine Mammary Tumour Cells Fulya Ustun Alkan*, Suzan Cınar, Ceren Anlas, Tulay Bakırel and Oya Ustuner Istanbul University, Turkey P1-064 Induction of Apoptosis of Propolis on Human Cervical Carcinoma Cell Lines Supakit Khacha-Ananda, Khajornsak Tragoolpua, Panuwan Chantawannakul and Yingmanee Tragoolpua* Chiang Mai University, Thailand The XIII 52 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-065 Induction of Apoptosis of Propolis on Human Cervical Carcinoma Cell Lines Supakit Khacha-ananda, Khajornsak Tragoolpua*, Panuwan Chantawannakul and Yingmanee Chiang Mai University, Thailand P1-066 The Comparisons of Bisphenol-A (BPA) Effect on Cultured Human Myometrial and Leiomyoma Cells Seung Bin Park and Myoungseok Han* Dong-A University, Korea P1-067 Dependency of 2-Methoxyestradiol-induced Apoptosis on G2/M-arrest and Prolonged Activation of Cdk1 in Human Jurkat T Cells Seung Tae Lee1, Cho Rong Han1, Ji Young Lee1, Do Youn Jun1, Hyo Young Kim1, Se Jin Kim2, Dongki Kim2, Seokjoon Jang2, Yoon Hee Kim2 and Young Ho Kim1* 1 Kyungpook National University, Korea, 2 Daegu Science High School, Korea P1-068 The Role of Annexin A5 in Cispatin-induced Apoptosis in Kidney Cells Dong-Jin Ye1, Jin-Joo Jung1, Na-Hee Park1, Aree Moon2 and Young-Jin Chun1* 1 Chung-Ang University, Korea, 2 Duksung Women's University, Korea P1-069 Auranoﬁ n Induces Mitochondrial Apoptosis through VDAC-Dependent Mechanisms Na-Hee Park, Yeo-Jung Kwon, Young-Shin Park, Sangyun Shin, Dong-Jin Ye, Nam-Hyeon Cho and Young-Jin Chun* Chung-Ang University, Korea P1-070 Induction of Apoptosis of SW480 Human Colon Cancer Cells by (-)-Epicatechin Isolated from Bulnesia Sarmienti Daeik Kim1, Mohammad Lalmoddin Mollah2, Yeonshik Choi3 and Kilsoo Kim4* 1 Daegu Technopark Oriental Medicine Industry Support Center, Korea, 2 Patuakhali Science and Technology University, Bangladesh, 3 Korea Bio Polytechnic College, Korea, 4 Kyungpook National University, Korea P1-071 Oxysterols Induce Senescence and Apoptosis with P2X7 Cell Death Receptor Activation on Human Retinal Cells Elodie Olivier1*, Eve Outin1, Melody Dutot2, Nicolas Auzeil1, Olivier Laprevote1 and Patrice Rat1 1 Universite Paris Descartes, France, 2 Yslab, France

P1-072 ~ 075 : Autophagy P1-072 Amyloid Beta Contributes to the Neurotoxic Effects of α-synuclein Aggregates in Neuronal Cells Chih-Li Lin*, Hsin-Hua Li, Yu-Shih Cheng and Ten-Jen Lai Institute of Medicine, Chung Shan Medical University, Taiwan P1-073 Activation of Autophagy Rescues Amiodarone-induced Apoptosis of Lung Epithelial Cells and Pulmonary Toxicity in Rats Kang-Yo Lee1, Sehee Oh1, Seon-Hee Oh2, Mi-Jin Yang3, Young-Soo Yang3, Kyuhong Lee3 and Byung-Hoon Lee1* 1 Seoul National University, Korea, 2 Chosun University, Korea, 3 Korea Institute of Toxicology, Korea P1-074 Uric Acid Inhibits Lipid Metabolism through Suppression of Autophagy Kang-Yo Lee, Chae-Hyeon Lee, You-Jin Choi and Byung-Hoon Lee* Seoul National University, Korea P1-075 PM2.5-induced Oxidative Stress Triggers Autophagy in Human Lung Epithelial A549 Cells Fang Zhang University of the Chinese Academy of Sciences, China

P1-076 ~ 102 : Biomarkers P1-076 Analysis of Urinary 2,5-Hexanedione to Illustrate True Exposure Scenarios for n-Hexane-exposed Workers by Using On-line Solid-phase Extraction Liquid Chromatography-tandem Mass Spectrometry Hsin-Chang Chen1, Ming-Huan Lin2, Shi-Nian Uang3, Yu-Fang Huang2 and Kuen-Yuh Wu2* 1 National Health Research Institutes, Taiwan, 2 National Taiwan University, Taiwan, 3 Council of Labor Affairs, Executive Yuan, Taiwan The XIII International Congress POSTER / JULY 1 (MON) 53 of Toxicology

P1-077 Global Methylation Pattern Alterations Correlate with Genomic Damage Biomarkers in Subjects Exposed to High-Dose Polycyclic Aromatic Hydrocarbon Huawei Duan Chinese Society Of Toxicology, China P1-078 Function of Hsa-miR-21-3p Associated with Risk for Esophageal Squamous Cell Carcinoma Ya Juan Shi, Ran Liu* and Li Hong Yin Southeast University, China P1-079 Artiﬁ cial miRNA Culd be Transferred into Esophageal Cancer Cells by Tumor-derived Exosomes Juan Liao, Ran Liu* and Lihong Yin Southeast University, China P1-080 Urinary 1-Hydroxypyrene Glucuronide Levels in a Chinese Population: Relation to PAH Exposure, Smoking and Gene Polymorphisms Yu Hu1*, Xiaonan Xue2, Zongcan Zhou3, Juanling Fu3, Xiaomei Li2, Gang Li4, Nirmal Roy2 and Qingshan Qu2 1 Hangzhou Normal University, China, 2 New York University School of Medicine Tuxedo, USA, 3 Peking University School of Public Health, China, 4 Liaoning Institute of Occupational Health and Medicine, China P1-081 Identifying of trans, trans-2,4,-Decadienal Metabolites in Mice and Human Cells Using Liquid Chromatography-mass Spectrometry Kao-Lu Pan1, Chia-Wei Cheng1, Huei-Ju Liu1, Hui-Ling Lee2, Ming-Hsien Tsai1, Mei-Ya Shen1 and Pinpin Lin1* 1 National Health Research Institutes, Taiwan, 2 Fu Jen Catholic University, Taiwan P1-082 Study on the Effect of Sub-chronic Exposure to Lead acetate on Hepatic Glucose Metabolism in Rat Sara Mostafalou1*, Ali Ramazani2, Maryam Baeeri3, Mehdi Gholami3, Elmira Ghafouri3, Armita Banani3, Elham Hosseini3 and Mohammad Abdollahi3 1 Tehran University of Medical Sciences and Iran National Science Foundation (INSF), Iran, 2 RWTH-Aachen University, Germany, 3 Tehran University of Medical Sciences, Iran P1-083 Development of Evaluating Methods for Sensitizing Chemicals by using Chemico-protein Adducts Toshihiro Kawamoto* and Mayumi Tsuji University of Occupational and Environmental Health, Japan P1-084 Alternative Proﬁ ciency Testing for Blood Toluene Analysis by Gas Chromatography/ Headspace Chalongkwan-Tangbanluekal, Thanyaporn-Pengkum and Chachawin-Rangabpai* Siriraj Hospital, Mahidol University., Thailand P1-085 Cigarette Smoking Alters the Expression of COX-2, P53, XIAP and MCL-1 in Gastric Cancer Mohammad H Ghahremani*, Nima Babhadiashr, Zahra Forouhesh Tehrani, Seyed Nasser Ostad, Masoud Sotoudeh and Reza Malekzadeh Tehran University of Medical Sciences, Iran P1-086 Association of Urinary N7-(2-Carbamoyl-2-Hydroxyethyl )Guanine, an Acrylamide-DNA Adduct, with Daily Intake of Acrylamide from Food Yu-Tzu Wei1, Chih-Chun J Huang2 and Kuen-Yuh Wu1* 1 National Taiwan University, Taiwan, 2 National Health Research Institutes, Taiwan P1-087 Repeated Measurements of Urinary N7GAG, an Acrylamide-DNA adduct, in Workers Exposed to Acrylamide by an Isotope Dilution Method with Two-step SPE and On-line LC-MS/MS Yu-Fang Huang1, Liou Saou-Hsing1, Mei-Lien Chen2*, Chih-Chun J Huang1, Shi-Nian Uang3 and Kuen-Yuh Wu4* 1 National Health Research Institutes, Taiwan, 2 National Yang Ming University, Taiwan, 3 Institute of Occupational Safety and Health, Taiwan, 4 Taiwan University, Taiwan P1-088 Analysis of Urinary Phthalic Acid for Phthalate-exposed Workers by using Liquid Chromatography- Tandem Mass Spectrometry Yen-Yu Chen1, Hsin-Chang Chen2, Yu-Fang Huang1 and Kuen-Yuh Wu1* 1 National Taiwan University, Taiwan, 2 National Health Research Institutes, Taiwan The XIII 54 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-089 In-vitro Toxicokinetics of Acrylamide: Glutathione Conjugation in Primary Rat Hepatocytes is Faster than Oxidation to Glycidamide Gerhard Eisenbrand1*, Denise Scherbl1, Nico Watzek1, Matthias Baum1, Jan G Hengstler2, Markus Schug2 and Elke Richling1 1 University of Kaiserslautern, Germany, 2 Leibniz Research Centre for Working Environment and Human Factors, Germany P1-090 Biomarkers Associated with Pathways of Disease Development Shu-Ting Chen and Kuen-Yuh Wu* College of Public Health, National Taiwan University, Taiwan P1-091 Biological Monitoring of Polycyclic Aromatic Hydrocarbons using 1-OH as a Biomarker in a Population of Monterrey, Mexico Lourdes Garza Ocanas1*, Jessica A Gonzalez Cardenas2, Roque M Mifuji Lira2, Christian T Badillo Castaneda2, Humberto J Garza Ulloa2, Ruben Lujan Rangel2 and Teresa Zannata Calderon2 1 Fac de Medicina Universidad Autonoma de Nuevo Leon, Mexico, 2 Pharmacology and Toxicology Department, Medicine School UANL, Mexico P1-092 Early Candidate Serum Biomarkers of Drug-induced Vascular Injury in Wistar Rats Matthew G Burbank1, Joelle Grenier De Cardenal2*, Olivier Wattrelos2*, Helene Bertheux2*, Romain Gauchet2, Claire Gignoux2, Richard J Weaver2 and Anne Beamonte2 1 University Paris Sud, France, 2 Drug Safety Assessment Centre, Biologie Servier, France P1-093 Promoter Hypermethylation in White Blood Cell DNA and Breast Cancer Risk Yoon Hee Cho* University of Montana, USA P1-094 Identiﬁ cation of Metabolomic Biomarkers for Early Detection of Acute Kidney Injury A Jin Won1, Tae Hyung Kim1, Yu Jin Shin1, Byung Mu Lee2, Suhkmann Kim1, Bu Young Chung2 and Hyung Sik Kim2 1 Pusan National University, Korea, 2 Sungkyunkwan University, Korea P1-095 Urinary and Plasma Metabolites for Potential Biomarkers of Acetaminophen Induced Hepatic Injury in Korean Ji Won Kim1, Sung Ha Ryu1, Deokwon Nam1, Siwon Kim2, Jeong Ju Seo3, Jaemin Cha3, Hae Won Lee3, Mi-Sun Lim3, Sook Jin Seong3, Suhkmann Kim2, Young-Ran Yoon3 and Kyu-Bong Kim1* 1 Dankook University, Korea, 2 Pusan National University, Korea, 3 Kyungpook National University, Korea P1-096 Toxicometabolomics Study for Prediction of Hepatotoxicity by Troglitazone in Rats Ji Won Kim1, Sung Ha Ryu1, Siwon Kim2, Suhkmann Kim2 and Kyu-Bong Kim1* 1 Dankook University, Korea, 2 Pusan National University, Korea P1-097 Proteomic Identiﬁ cation of Novel Biomarkers for Evaluation of Nephrotoxicity Young-Jun Shin1, Jeong-Hyeon Kim1, Hyung Sik Kim2, Tae Cheon Jeong3 and Ok-Nam Bae1* 1 Hanyang University, Korea, 2 Pusan National University, Korea, 3 Yeungnam University, Korea P1-098 Fibrinogen-like Protein 1 (FGL1), the Potential Biomarker for Radiation-induced Liver Injury Myung Gu Jung, Ye Ji Jeong, Yoon-Jin Lee and Hae-June Lee* Korea Institute of Radiological and Medical Sciences, Korea P1-099 Comparison of Biomarkers for Nephrotoxicity between in Vitro and in Vivo Hang Sik Roh, Ji Hyeon Seok, Ji-Hyun Yun, Hye Kyung Choi, Joo-Hyun Jee, Jong Kwon Lee, Tae Sung Kim, Young Hee Jo, Soon Young Han and Ja Young Jeong* National Institute of Food & Drug Safety Evaluation, MFDS, Korea P1-100 Oxidative Stress Biomarkers in Residents 4 years after the Hebei Spirit Oil Spill Su Ryeon Noh1, Jung Ah Kim1, Gwi Heum Eom1, Hyun Sook Bae1, Seon Young Ka1, Young-Hyun Choi1, Mina Ha2* and Hae-Kwan Cheong3* 1 Taean Environmental Health Center, Korea, 2 Dankook University College of Medicine, Korea, 3 Sungkyuonkwan University School of Medicine, Korea P1-101 A Plot Study of Small Molecular Metabolites in Esophageal Cancer Plasma with LC-MS Assay Yuan Peng, Hong L Yin and Ran Liu Southeast University, China The XIII International Congress POSTER / JULY 1 (MON) 55 of Toxicology

P1-102 The Proteome Response of Oyster to Long Term Exposure to High-CO2 Dineshram Ramadoss The University of Hong Kong, Hong Kong

P1-103 ~ 119 : Biomonitoring P1-103 Assessment of Exposure and Early Effect of Formaldeyde in a Group of Pathology and Anatomy Workers Solange Costa1, Carla Costa2, Patricia Coelho2, Susana Silva1, Beatriz Porto3 and Joao P Texeira2* 1 National Institute of Health, Portugal, 2 Institute of Public Health of the University of Porto, Portugal, 3 Institute of Biomedical Sciences Abel Salazar-University of Porto, Portugal P1-104 A Study on the Association between Urinary Aluminum Concentration and Pre-clinical Findings among the Aluminum Handling and Non-handling Workers Masanori Ogawa* and Fujio Kayama Jichi Medical University, Japan P1-105 Interpretation of Human Biomonitoring Data from the Canadian Health Measures Survey in a Risk-based Context Kate Werry1*, Annie St-Amand1, Andy Nong1, Sean M Hays2 and Lesa L Aylward2 1 Health Canada, Canada, 2 Summit Toxicology LLP, USA P1-106 Can Chromium in Erythrocytes Contribute to Biomonitoring of Cr(VI) ? Jerome Devoy*, Guillaume Antoine, Mathieu Melczer, Samuel Muller and Isabelle Sponne INRS, France P1-107 Effects of Particulate Matters Exposure on Oxidative Damage and Inﬂ ammatory Responses in People residing in Traﬃ c Congested Areas in Bangkok Ormrat Kampeerawipakorn, Udomratana Vattanasit, Suppachai Choonvisase, Netnapa Nakngam, Samroeng Chantchaemsai, Panida Navasumrit and Mathuros Ruchirawat* Chulabhorn Research Institute,Thailand P1-108 Biomonitoring Environmental Water Quality with the Medaka Embryo (Oryzias Latipes) Wenjau Lee Chang Jung Christian University, Department of Bioscience Technology, Taiwan P1-109 Polychlorinated Dibenzofurans Levels in Fresh Milk of the Dairy Factories from Southwest Iran Mohsen Rezaei*, Zahra Nazari, Azadeh Nakisa and Saeed Rezaee JondiShapoor University of Medical Sciences, Iran P1-110 New Evidences about Adverse Health Effects and Their Translation in Health Surveillance Proposal for Chromate Manufacturing Workers Yang Li1, Guang Jia1*, Shan F Yu2 and Ji Zhang3 1 Peking University, China, 2 Henan Provincial Institute of Occupational Health,China, 3 Jinan City Center for Disease Control and Prevention, China P1-111 Estrogen Receptor Status and Concentration of Organochlorine Pesticides in the Subjects Suffering from Breast Cancer Madhu Anand1*, Vipul K Singh2, M K J Siddiqui3, Ajay Taneja1 and P K Mehrotra4 1 Institute of Basic Sciences, India, 2 Indian Institute of Toxicology Research, India, 3 Council of Science and Technology-Uttar Pradesh, India, 4 Sir Ganga Ram Hospital, India P1-112 Relationship between Dietary Mercury Uptake and Blood Mercury Level in Korea Young-Seoub Hong1, Chand-Hun You1*, Byoung-Gwon Kim1, Jinyong Chung2 and Jeongwook Seo1 1 Dong-A University, Korea, 2 Heavy Metal Exposure Environmental Health Center, Korea P1-113 Variability of Creatinine Excretion within and among Individuals Hyun Kyung Na and Mihi Yang* Research Center for Cell Fate Control, College of Pharmacy, Sookmyung Women’s University, Korea P1-114 How Much Impact of Brominated Flame Retardants as Endocrine Disrupting Chemicals for Human in Korea? Un-Jung Kim1, Yong-Hee Hong2, Dong-Hwan Lee2 and Jeon-Eun Oh1* 1 Pusan National University, Korea, 2 Soonchunhyang University, Korea The XIII 56 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-115 Application of Competitive ELISA Method for Estimation of Urinary Aﬂ atoxin M1 Level Yong-Dae Kim1*, Hyojin Kwon1, Sun-In Moon1, Sang-Yong Eom1, Dong-Hyuk Yim1, Hyoung-Chan Oh1, Gwang-Jin Kim2, Hae- Jung Yoon2, Young-Sook Choi1, Ho-Jang Kwon3 and Heon Kim1 1 Chungbuk National University, College of Medicine, Korea, 2 National Institute of Food and Drug Safety Evaluation, Korea, 3 Dankook University College of Medicine, Korea P1-116 Association between Thyroid Function and Body Mass Index in Korean Population Wook Hee Choi, Hyun Jeong Kim, Kyung Hwa Park* and Seung Do Yu National Institute of Environmental Research, Korea P1-117 Response Behavior Gathering of Caenorhabditis Elegans after Exposure to Benzene Bo-Moon Kim1, Hungsoo Kim2, Kwak-Gyu Suk3, Golam M. Mortuza4 and Tae-Soo Chon1* 1 Pusan National University, Korea, 2 Gyungnam National University, Korea, 3 Institution of Environmental Studies, Korea, 4 King Saudi University, Bangladesh P1-118 A Biomonitoring Study on Blood Mercury Levels in Korean General Population Moon Young Hwang, Hyun Jeong Kim, Young Mee Lee, Soon Won Jung, Na Young Lee, Hye Jeong Jo, Jeong Hui Song, Soo Yeon Hong, Seung Do Yu and Choong Hee Park* National Institute of Environmental Research, Korea P1-119 Monitoring of Male Sex Hormone in Urine of Sex Offenders Seungkyung Baeck*, Sujin Jung, Sunhye Park, Boyoung Jeong, Sangki Lee and Yonghun Park National Forensic Service (NFS), Korea

P1-120 ~ 139 : Carcinogenesis P1-120 Investigation Polyaromatic Hydrocarbons Dibenzo(α,h)anthracen Concenteration in Awaz Ambient Air Aazam Derakhshannezhad Ahwaz Jumdishapur University of Medical Sciencs, Iran P1-122 Synthesis and Antitumor Activity of Fluorocyclopentenyl-pyrimidines Shantanu Pal1 and Lak Shin Jeong2* 1 IIT-Bhubaneswar, India, 2 Ewha Womans University, Korea P1-123 MicroRNA-17/20a Regulates Oral Squamous Cell Carcinoma Progression by Suppressing Integrin Beta 8 Signaling Cheng-Ning Yang, Ching-Ting Tan, Yu-Jen Yang and Cheng-Chi Chang* National Taiwan University, Taiwan P1-124 Mir-29b Enhanced Cell Migration via CX3CL1 Signaling in Oral Squamous Cell Carcinoma Yue-Ju Li, Ching-Ting Tan, Jia-Yu Tang and Cheng-Chi Chang* National Taiwan University, Taiwan P1-125 Involvement of Prostaglandin Terminal Synthases in Chemical-induced Colon Carcinogenesis Yuka Sasaki and Shuntaro Hara* Showa University, Japan P1-126 CYP2E1 Polymorphisms, Response to Chemotherapy and Survival in Non-Small Cell Lung Cancer Patients Ahmet O Ada1*, Volkan Karacaoglan1, Semih C Kunak2, Sibel Alpar3, Meral Gulhan3 and Mumtaz Iscan1 1 Ankara University, Turkey, 2 Giresun University, Turkey, 3 Ataturk Pulmonary Diseases and Thoracic Surgery Hospital, Pulmonary Diseases Clinic, Turkey P1-127 Application of the Mode-of-Action (MOA) and Human Relevance Framework (HRF) Analysis in Human Cancer Risk Assessment Renjun Gao1*, Jing Dong2, Summer Shen2, Bryce Landenberger3 and Lynn H Pottenger3 1 Dow Chemical China (Investment) Company Limited, Beijing, China, 2 Dow Chemical China (Investment) Company Limited, Shanghai, China, 3 The Dow Chemical Company, Midland, USA P1-128 Serum miR-206 and miR-133b as a Potential Biomarker for Lung Carcinogenesis Induced by 4-(methylnitrosamino)-1-(3-pyridyl) -1-butanone Jianjun Wu1, Jinkun Huang1, Ti Yang1, Xun Li1, Qiaoyuan Yang1, Rong Liu1, Yuanqi Li1, Chengfeng Yang2 and Yiguo Jiang1* 1 Guangzhou Medical University, China, 2 Michigan State University, USA The XIII International Congress POSTER / JULY 1 (MON) 57 of Toxicology

P1-129 Anti-cancer Effects of Coptis Chinensis and Evodia Rutaecarpa in HepG2 Cells and in an Orthotopic Intrahepatic Xenograft Model Su-Yin Chiang1, Shun-Ting Chou1, Ming-Tsung Lai2, Kuen-Yuh Wu3, Chien-Yun Hsiang1 and Tin-Yun Ho1* 1 China Medical University, Taiwan, 2 Chung-Shan Medical University, Taiwan, 3 National Taiwan University, Taiwan P1-130 Thymus and Lymph Nodes at Experimental Prostate Tumor Andrei A Lomshakov1* and Vadim V Astashov2* 1 Institute of Clinical and Experimental Lymphology SB RAMS, Russia, 2 Institute of Biocides and Nanobiotechnology, Russia P1-131 Chemical Carcinogens are Potential Regulator of Nitric Oxide Production in Human Serum Ki-Young Moon* Department of Clinical Pathology, Gwangju Health University, Korea P1-132 1-Bromopropane Induces Mast Cell Degranulation and Enhances Infl ammatory Mediator Production via Calcium Infl ux in RBL-2H3 Cell Hwa Jeong Han1, Hyung Gyun Kim1, Tae Cheon Jeong2 and Hye Gwang Jeong1* 1 Chungnam National University, Korea, 2 Yeungnam University, Korea P1-133 Integrative DNA Methylation and Gene Expression Analysis in Cardia and Noncardia Gastric Cancer Minkyo Song1, Hyuna Sung1, Lian Li2, Ji-Yeob Choi1 and Daehee Kang1* 1 Seoul National University College of Medicine, Korea, 2 Tianjin Medical University Cancer Institute and Hospital, China P1-134 Pin1 is Required for Ultraviolet A-stimulated Cyclooxygenase-2 Expression in Epidermal Cells Bui T Quyen, Ji Hye Im and Keon Wook Kang* College of Pharmacy, Seoul National University, Korea P1-135 Helicobacter Pylori Induces STAT3 Tyr705 and Ser727 Phosphorylation in Human Gastric Epithelial Cells Juan-Yu Piao, Hee-Geum Lee, Hyeon-Geum Ji, Do-Hee Kim, Su-Jung Kim and Young-Joon Surh* Seoul National University, Korea P1-136 Helicobacter Pylori Induces Snail Expression via GSK-3β Signaling in Human Gastric Cancer Cells Hoang Kieu Chi Ngo, Juan-Yu Piao, Hee-Geum Lee and Young-Joon Surh* Seoul National University, Korea P1-137 Regulation of Hypoxia-inducible Factor-2α Stability by Peptidyl Prolyl Isomerase PIN1 Min-A Choi1, Hyeong-Jun Han1, Bu Young Choi2, Na-Young Kwon1 and Young-Joon Surh1* 1 Seoul National University, Korea, 2 Seowon University, Korea P1-138 15-Deoxy-Δ12,14-prostaglandin J2-Induced Epithelial-to-Mesenchymal Transition in Human Breast Cancer Cells Promotes Fibroblast Activation Jeehye Choi, Jin-Young Suh, Do-Hee Kim and Young-Joon Surh* Seoul National University, Korea P1-139 15-Deoxy-Δ12,14-prostaglandin J2 Induces Phosphorylation of Akt via Covalent Modifi cation and Subsequent Inactivation of PTEN in MCF-7 cells Jin-Young Suh1, Jong-Min Park1, Sin-Aye Park1, Hye-Kyung Na2, Zigang Dong3 and Young-Joon Surh1* 1 Seoul National University, Korea, 2 Sungshin Women’s University, Korea, 3 Hormel Institute, University of Minnesota, USA

P1-140 ~ 148 : Cardiotoxicity P1-141 Direct Evidence for PDCD10 (CCM3) Playing an Important Role in the Initiation, Promotion and Progression of Cavernous Angioma Yun He1, Haifeng Zhang2, Vortmeyer Alexander2 and Wang Min2* 1 Sun Yat-Sen University School of Public Health, China, 2 Yale University, USA P1-142 Effect of Theophylline on Serum Magnesium ,Uric Acid and Nitric Oxide in Asthmatic Children Azza M Ahmed National Research Center, Egypt The XIII 58 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-143 Involvement of Heme Oxygenase-1 in Attenuation of the Cardioprotective Effect of Ischemic Preconditioning in Diabetic Rat Heart Shubham Goyal1, Ishan Gupta2* and Vaneeta Goyal3* 1 Baddi University of Emerging Sciences and Technology, India, 2 Panacea Boitech, India, 3 Himalyan institute of Pharmacy, India P1-144 Dihydrotestosterone Increases Protein Abundance and Current Density of Ether-a-go-go-related Gene Encoded K+ Channel in Isolated Beagle Dog Cardiac Myocytes Wanyi Wang1, Sungchun Kim2, Sunny Z Sun2, Nagappan Mathialagan2, Yao Pan1, Jianjun Jiang1, Lanqin Shang1, Shuang Wu1, Bernard Fermini2 and Weidong Hao1* 1 Peking University, China, 2 Pfi zer Global R&D, USA P1-145 The Evaluation of Ferulate Effects in Adricin Toxicity Hala Malek Mansoura-Faculty of Medicine, Egypt P1-146 Endothelium-dependent Vascular Relaxation by Quercus Salicina Leaf Extract : the Role of NO Su-Young Song, Sin-Hee Park, Soo-Jin Kim and Min-Ho Oak* Mokpo National University, Korea P1-147 Biomarkers of Infl ammation and Coagulation in Welders Dag G Ellingsen1, Valery Chashchin2, Ingebjørg Seljefl ot3, Maxim Chashchin2 and Yngvar Thomassen1 1 National Institute of Occupational Health, Norway, 2 Northwest Public Health Research Centre, Russia, 3 Oslo University Hospital Ulleval, Norway P1-148 Protection Effects of Basil on Cardiac Cells Apoptosis after Chronic Exposure to Electromagnetic Field (EMF) in Rats by TUNEL Assay Arash Khaki1*, Amir A Khaaki1, Fatemeh Fathiazad2 and Seppan Prakash3 1 Islamic Azad University, Iran, 2 Tabriz University of Medical Sciences, Iran, 3 University of Medical Sciences, India

P1-149 ~ 173 : Cell Signaling and Gene Expression P1-149 Protective Effects of Dunaliella against to Co-administration of Ethanol and DEHP-suppressed GPx Activity and Total Antioxidative Aapacity in Human HepG2 Cells Jong-Yuh Cherng1, Shu-Fen Liou2 and Mei-Fen Shih2 1 National Chung Cheng University, Taiwan, 2 Chia-Nan University of Pharmacy & Science, Taiwan P1-150 Microsomal Prostaglandin E synthase-1 Plays an Important Role in Strain-difference in the Onset of TCDD-induced Hydronephrosis in Mice Keiko Aida-Yasuka, Wataru Yoshioka, Tatsuya Kawaguchi, Seiichiroh Ohsako and Chiharu Tohyama* University of Tokyo, Japan P1-151 Chronic Intracerebroventricular Lipopolysaccharide Injection Increases Gene Expression of Connexin30 and 32 in Rat Hippocampus Mohammad Abbasian Islamic Azad University, Iran P1-152 Integrin β3 Determines the Role of OPN-a in Growth Control of Lung Cancer Shih-Jung Sun Chung Shan Medical University, Taiwan P1-153 Activation of G Protein-coupled Inwardly Rectifying K+ Channels in Human Embryonic Kidney 293 Cells Coexpressing μ-Opioid and Opioid Receptor-like 1 Receptors Cynthia Wei-Sheng Lee1*, Hung-Li Wang2 and Ing-Kang Ho1 1 China Medical University Hospital, Taiwan, 2 Chang Gung University School of Medicine, Taiwan P1-154 The Protective Role of AMP-activated Protein Kinase-evoked Autophagy in Ischemia/Reperfusion- induced Renal Cell Death Chen Bo Lin, Wang Li Ting, Chiang Chih Kang* and Liu Shing Hwa* National Taiwan University, Taiwan The XIII International Congress POSTER / JULY 1 (MON) 59 of Toxicology

P1-155 Crosstalk between Constitutive Androstane Receptor and Hypoxia-inducible Factor in the Regulation of Gene Expression Satoshi Numazawa1*, Ryota Shizu2 and Takemi Yoshida1 1 Showa University School of Phamacy, Japan, 2 Tohoku University, Japan P1-156 Arsenic Induces ERK Activation in A549 Cell through ROS Generation and EGFR Activation Piyajit Watcharasit, Daranee Visitnonthachai, Sumitra Suntararuks and Jutamaad Satayavivad* Chulabhorn Research Institute, Thailand P1-157 Nifedipine Induces Gingival Hyperplasia via Transforming Growth Factor-beta Pathway Regulated Periostin Shawna S Kim, Linda Jackson-Boeter, Mark Darling, Michael J Rieder and Douglas W Hamilton* Schulich School of Medicine and Dentistry, University of Western Ontario, Canada P1-158 Relationship Between Phosphorylation of Water Channel Protein AQP9 and Arsenic Tolerance in Human Umbilical Vein Endothelial Cells Yifei Cao Hangzhou Normal University, China P1-159 Down-regulation of Soluble Epoxide Hydrolase by SP1 Under Oxidative Stress Condition Ami Oguro and Susumu Imaoka* School of Science and Technology, Kwansei Gakuin University, Japan P1-160 CYP1B1 Induces MCF-7 Cell Proliferation through Activation of Wnt Signaling Pathway Yeo-Jung Kwon, Na-Hee Park, Dong-Jin Ye, Namhyeon Cho, Sangyun Shin, Young-Shin Park and Young-Jin Chun* Chung-Ang University, Korea P1-161 GOLGA2/GM130, Cis-golgi Matrix Protein, is a Selective Target of Anticancer Gene Therapy Sung-Jin Park, Seung-Hee Chang, Seong-Ho Hong, Kyeong-Nam Yu, Ji-Young Shin, Jae-Ho Lee and Myung-Haing Cho* College of Veterinary Medicine, Seoul National University, Korea P1-162 Lung Cancer Suppression by Biocompatible Glycerol triacrylate-spermine-mediated Delivery of shAkt1 Seong-Ho Hong, Ji-Eun Kim, Ji-Young Shin, Chong-Su Cho, Hu-Lin Jiang* and Myung-Haing Cho* Seoul National University, Korea P1-163 GDK-100017, a Small Molecule Inhibitor of the Wnt/beta-catenin Signaling Pathway Suppresses Cell Proliferation and Enhances Radiosensitivity in A549/Wnt2 Cells Sang Bum Lee and Mi-Sook Dong* School of Life Sciences and Biotechnology, Korea University, Korea P1-164 CYP1B1 Regulates TRAIL Expression and Other Related Factors Nam-Hyeon Cho, Na-Hee Park, Yeo-Jung Kwon, Young-Shin Park, Sang-Yun Shin, Dong-Jin Ye and Young-Jin Chun* Chung-Ang University, Korea P1-165 DNA Microarray Proﬁ ling of Genes Differentially Regulated by Three Heterochromatin Protein 1 (HP1) Homologs in Drosophila Dong Hoon Lee, Yingxiu Li, Dong-Hee Shin and So Hee Kwon* Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Korea P1-166 Dynamic Expression of Thioredoxin and Its Encouraging Effect on Cell Proliferation during Liver Regeneration Byung-Woo Lee1, Byung-Seok Jeon1, Yoko Hirabayashi2, Tohru Inoue2, Junji Yodoi3, Dae-Yong Kim4 and Byung-Il Yoon1* 1 Kangwon National University, Korea, 2 National Institute of Health Sciences, Japan, 3 Kyoto University, Japan, 4 Seoul National University, Korea P1-167 Reactive Oxygen Species Play a Critical Role in Collagen-induced Platelet Activation via SHP-2 Oxidation Ji Yong Jang1, Jin Young Baek1, Ji Hyun Min1, Yun Hee Chae1, Su Bin Wang1, Goo Taeg Oh1, Sang-Hak Lee2, Ye-Shih Ho3 and Tong-Shin Chang1* 1 Ewha Womans University, Korea, 2 Yonsei University College of Medicine, Korea, 3 Wayne State University, USA P1-168 Non-genomic Effects of PPARγ ligand, KR-62980, on Collagen-stimulated Platelets Su Bin Wang1, Ji Yong Jang1, Jin Young Baek1, Jin Hee Ahn2 and Tong-Shin Chang1* 1 Ewha Womans University, Korea, 2 Korea Research Institute of Chemical Technology, Korea The XIII 60 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-169 The Role of Sestrin2 on LXRα-mediated Lipogenic Gene Suppression by Resveratrol Sung Hwan Ki1* and Il Je Cho2* 1 Chosun University, Korea, 2 Daegu Haany University, Korea P1-170 Aromatase Induction in Tamoxifen Resistant Human Breast Cancer: Role of Phosphoinositide 3-kinase- dependent CREB Activation Nguyen Tt Phuong1 and Keon Wook Kang2* 1 College of Pharmacy, Chosun University, Korea, 2 College of Pharmacy, Seoul National University, Korea P1-171 The CCAAT/Enhancer-binding Proteinβ (C/EBPβ) is Critical Regulator for Wee1 in G2/M Arrest of Cell Cycle Progression Eun Kyung Choi, Bo Ram Kang and Kyungsil Yoon* Lung Cancer Branch, National Cancer Center, Korea P1-172 TNF- α Dependent cIAP2 Processing and Domain Mapping for Binding C2AF Ha-Rim Choi Nambu University, Korea P1-173 Cross-talk of Signalings between NF-κB and AhR or HIF-1α Shoko Oida, Ami Oguro and Susumu Imaoka* School of Science and Technology, Kwansei Gakuin University, Japan

P1-174 ~ 206 : Cellular Effects of Natural Products P1-174 Evaluation of Drought Tolerance Criteria in Sunﬂ ower Genotypes (Helianthus Annuus L) in Temperate Regions of Kermanshah Arash M Tavakoli Pouran Islamic Azad University, Iran P1-175 Effect of Drought Stress on Chemical Constituents, Photosynthesis and Antioxidant Properties of Rosmarinus Oﬃ cinalis L. Essential Oil Rozbeh Farhoudi1 and Dong Jin Lee2 1 Islamic Azad University, Iran, 2 Dankook University, Korea P1-176 Tanshinone IIA Mediates through Estrogen Receptors to Activates Akt and Inhibit Apoptosis Effect of Leu27IGF-II-induced IGF-II Receptor Signaling Activation in Myocardiac Cells Yueh-Shan Weng1* and Chih-Yang Huang2* 1 China Medical University, Taiwan, 2 Asia University, Taiwan P1-177 16-Hydroxy-cleroda-3,13-dien-16,15-olide Inhibits the Epithelial-mesenchymal Transition and Induces the Apoptosis in Brain Tumors Thiyagarajan Varadharajan1, Yi Chen Chia2 and Ching Feng Weng1* 1 National Dong Hwa University, Taiwan, 2 Tajen University, Taiwan P1-178 Impact of Curcumin on Paclitaxel: Enhanced Oral Bioavailability through in Situ Perfusion and in Vivo Pharmacokinetic Studies Ranjith K Kankala1, Ishtiyaq A Najar2, Vamshi Valala2, Chia H Lee1, Rakesh K Johri2 and Chen L Liu1* 1 National Dong Hwa University,Taiwan, 2 CSIR- Indian Institute of Integrative Medicine, India P1-179 Mitochondrial Dysfunctions in Brain Regions of Young Mice Fed Khesari Dhal : Amelioration by Centella asiatica Leaf Powder Incorporated Diet Shinomol George1, Srinivas Bharath M M1 and Muralidhara M2 1 National Institute of Mental Health and Neuro Sciences, India, 2 Central Food Technological Research Institute (CFTRI), India P1-180 Inhibitory Effects of Terrein on Cervical Carcinoma Cell Line Adhesion, Invasion and Migration Sukanya Pengpanich1, Sirinun Nilwarangkoon1, Faongchat Jarintanan2, Suchada Jongrungruangchok3 and Wanlaya Uthaisang- Tanechpongtamb1* 1 Srinakharinwirot University, Thailand, 2 Rangsit Univesity, Thailand, 3 Faculty of Pharmacy, Thailand The XIII International Congress POSTER / JULY 1 (MON) 61 of Toxicology

P1-181 Effects of Ethyl Acetate Fraction of Cocos Nucifera Linn (West African Tall Variety) Husk Fibre Extract on Selected Kidney and Brain Parameters In Mice Elizabeth A Balogun* University of Ilorin, Nigeria P1-182 Non-addictable Alkaloids of Opium Show Distinctive Cytotoxicity and Genotoxicity on Cancer Cell Lines Monire Afzali1, Mahnaz Khanavi1, Malihe Parsa1, Hamed Montazeri2, Mohammad H Ghahremani1 and Seyed Nasser Ostad1* 1 Tehran University of Medical Sciences, Iran, 2 Pasteur Institute Iran, Iran P1-183 Induction of Oxidative Stress as an Early Event of Anti-proliferative Effect of Methanol Extract of Herbal Formulation C168 on Colorectal Carcinoma Cell Hct 116 Nor Fadilah Rajab*, Lek Mun Laong, Kok Meng Chan, Asmah Hamid, Jalifah Latip, Anuar Osman and Salmaan H Inayat-Hussain Universiti Kebangsaan Malaysia, Malaysia P1-184 Effects of Sesamol on Matrix Metalloproteinases in H508 Human Colon Cancer Cell Line Apinya Thiantanawat*, Pishyaporn Sritangos, Daranee Visitnonthachai, Nujorn Srisamut, Piyajit Watcharasit and Jutamaad Satayavivad Chulabhorn Research Institute Lak Si, Thailand P1-185 Inhibition of Human HepG2 Cells against Oxidative Stress and Inducing Apoptosis by Garlic Oil Cuili Zhang and Keqin Xie* Shandong University, China P1-186 Adaptogenic Activity of Seabuckthorn on Cognitive Functions and Endurance Performance Shalini Saggu1*, Hasibur Rehman2 and Ratan Kumar3 1 University of Tabuk, Saudi Arabia, 2 University of Tabuk, Saudi Arabia, 3 DIPAS, India P1-187 Subchronic Haemotoxic, Biotoxic and Histotoxic Effects of Citrullus Colocynthis Extract in Albino Rats Ame Elgerwi1*, Abubakr El-Mahmoudy2 and Zuhira Benzekri3 1 Tripoli University, Libya, 2 Benha University, Egypt, 3 Menchya Clinic, Ministry of Health, Libya P1-188 Antioxidant Activities of Extract from Riceberry Rice Bran and the Effects on Oxidative Stress in Caco-2 Cells Yaiprae Chatree, Ratchanee Kongkachuichai, Thidarat Rujirawat, Yupin Visetpanit, Bunyada Jittorntrum, Supanart Srisala and Rodjana Chunhabundit* Mahidol University, Thailand P1-190 Genistein Reversed 17beta-estradiol or Bisphenol A-induced Growth of BG-1 Ovarian Cancer Cells via Suppression of Interaction Between Estrogen Receptor and Insulin Like Growth Factor 1 Receptor Kyung A Hwang and Kyung-Chul Choi* Chungbuk National University, Korea P1-191 Downregulation of Estrogen Receptor Alpha and Insulin-like Growth Factor-1 Receptor Is Involved in Anticancer Effects of Resveratrol on BG-1 Ovarian Cancer Cell Growth Induced by Bisphenol A Kyung A Hwang, Nam Hee Kang and Kyung-Chul Choi* Chungbuk National University, Korea P1-192 Anti-inﬂ ammatory and Antioxidant Activities of Isorhamnetin Kyuhwa Seo, Ji Hye Yang, Sung Hwan Ki and Sang Mi Shin* Chosun University, Korea P1-193 Screening of AMPK Activator from Herbal Extract Minyoung Baik, Yong-Seok Choi* and Mi-Sook Dong* Korea University, Korea P1-194 BSMA Inhibit Melanin Synthesis through Blocking PAR-2 Signaling Pathway Induced by UV Irradiation Eunsun Jung, Jung-A Lee, Yum Beom Kim and Deokhoon Park* Biospectrum Life Science Institute, Korea P1-195 Protective Activity of Bioactive Components in Dendropanax Morbifera against Cisplatin-induced Nephrotoxicity Eun-Sun Kim1, Jong-Soo Lee2, Seung-Hoon Baek3 and Ok-Nam Bae1* 1 Hanyang University, Korea, 2 CLIK Institute, Korea, 3 Ajou University, Korea The XIII 62 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-196 Kuwanon V Promotes Neurogenesis in Rat Neural Stem Cells Hyun-Jung Kim1*, Sun-Young Kong1, Minhye Park1 and Sang-Hyun Sung2 1 Chung-Ang University, Korea, 2 Seoul National University, Korea P1-197 Fermented Red Ginseng (Panax Ginseng C.A. Meyer) Increases Insulin Sensitivity and Improves Blood Glucose Levels in Adult ob/ob Mice Jeong-Mu Cheon1, Yeonshik Choi2 and Kilsoo Kim1* 1 Kyungpook National University, Korea, 2 Korea Bio Polytechnic College, Korea P1-198 Saponins from Platycodon Grandifl orum and its Constituent Platycodin D Inhibit Hepatic Lipogenesis by Activation of AMP-activated Protein Kinase Yong Pil Hwang1, Jae Ho Choi2, Hyung Gyun Kim2, Tilak Khanal2, Hyun-Sun Lee3, Young Chul Chung1, Young Chun Lee1 and Hye Gwang Jeong2* 1 International University of Korea, Korea, 2 Chungnam National University, Korea, 3 Korea Research Institute of Bioscience and Biotechnology, Korea P1-199 Effect of Cosmetics Containing Purifi ed Honeybee (Apis mellifera L.) Venom on Acne Vulgaris Sangmi Han* and Kwanggill Lee National Academy of Agricultural Science, Korea P1-200 Estrogenic Effect of Rhus vernicifl ua Extract and its Purifi ed Compounds Seunghan Sun1, Chun-Soo Na2, Dong-Ho Lee1, Byung-Yoon Ahn1 and Mi-Sook Dong1* 1 Korea University, Korea, 2 Lifetree Biotech Co. Ltd, Korea P1-201 Fucoxanthin Protects Cultured Human Keratinocytes against Oxidative Stress by Blocking Free Radicals and Inhibiting Apoptosis Jian Zheng and Jin Won Hyun* Jeju National University, Korea P1-202 Red Ginseng: Potential Candidate for the Prevention of Liver Fibrosis Il Je Cho1*, Sung Hwan Ki2, Sang Chan Kim1, Sung Hui Byun1 and Young Woo Kim1 1 Daegu Haany University, Korea, 2 Chosun University, Korea P1-203 Roots of Erigeron Annuus Inhibits Acute Infl ammation as Mediated with the Inhibition of NF-κB Activation Sang Chan Kim*, Il Je Cho, Sung Hui Byun and Young Woo Kim Daegu Haany University, Korea P1-204 Bojesodok-eum, an Herbal Prescription, Prevents Acute Infl ammation in Association with the Inhibition of NF-kappaB Activation Young Woo Kim*, Kook Ho Sohn, Il Je Cho, Sang Chan Kim and Seon Young Jee* Daegu Haany University, Korea

P1-205 Nectandrin B Inhibits Neointimal Formation: Inhibition of Pin1 Expression through AMPK Activation Ji Hye Im1, Moo Yeol Lee2 and Keon Wook Kang1* 1 Seoul National University, Korea, 2 Dongguk University, Korea P1-206 Saururus Chinensis Extract May Attenuate Styrene-induced Toxicity in Testicular Germ Cells Sang Hyun Sohn, Pil Sang Park, Seung Ok Yang, Young Ock Kim, Yu Su Shin, Hyung Don Kim, Seung Yu Kim and Sang Won Lee* National Institute of Horticultural & Herbal Science, Rural Development Administration, Korea

P1-207 ~ 228 : Chemoprevention P1-207 Diﬃ culties in the Treatment of Poisonings by Carbamates Valerii D Tonkopii Institute of Limnology, Rus.Acad.Sci., Russia P1-208 The Effects of Areca Nut Extract on β-amyloid Induced Neurotoxicity in Vitro and in Vivo Tsung-Yun Liu National Yang-Ming University, Taiwan The XIII International Congress POSTER / JULY 1 (MON) 63 of Toxicology

P1-209 Chemoprotective Activity of Grape Juice Concentrate in Chemically Induced Oral Carcinogenesis by 4-Nitroquinoline 1-Oxide: Role of Inﬂ ammatory Mediators Daniel A Ribeiro Federal University of Sao Paulo, Brazil P1-210 Effect of Eryngium Foetidum Linn. on AOM/DSS - Induced Mouse Colon Tumors Kamonwan Promtes1, Piengchai Kupradinun2, Anudep Rungsipipat3, Siriporn Tuntipopipat1 and Chaniphun Butryee1* 1 Mahidol University, Thailand, 2 National Cancer Institute, Thailand, 3 Chulalongkorn University, Thailand P1-211 Chemopreventive Effects of Silibinin Against Arsenic- induced Skin Carcinogenesis in Vitro and in Vivo Vandana Prajapati, Raosaheb K Kale and Rana P Singh* Jawaharlal Nehru University, India P1-212 Modulation of Nrf2-Regulated Cytoprotective Enzymes by Crude Drugs Tomokazu Ohnuma, Yohei Suzuki, Eri Anzai, Takahito Nishiyama, Kenichiro Ogura and Akira Hiratsuka* Tokyo University of Pharmacy and Life Sciences, Japan P1-213 Baicalein Induces p27kip Degradation through PI3K-Akt Pathway Pinxiuan Huang and Yahsin J Cheng* China Medical University, Taiwan P1-214 Cancer Chemopreventive Effects of Spirogyra Neglecta (Hassall) Kutzing using in Vitro and in Vivo Testing Systems Rawiwan Wongpoomchai*, Tarika Thumvijit, Sirinya Taya and Yuwadee Peerapornpisal Chiang Mai University, Thailand P1-215 Chemopreventive Role of Glutathione on Nitric Oxide Production in Benzyl Bromide-treated Human Serum Doo-Sin Jo and Ki-Young Moon* Department of Clinical Pathology, Gwangju Health University, Korea P1-216 Cellular Protection Effect of Kaempferol against Paraquat-induced Oxidative Stress in Human Bronchial Epithelial BEAS-2B Cells Biswajit Podder, Ho-Yeon Song* and Yong-Sik Kim* Soonchunhyang University, Korea P1-217 Chemoprevention by Acetylsalicylic Acid and Salicylate through Regulation of Nitric Oxide Production in Human Serum Ki-Young Moon* Gwangju Health University, Korea P1-218 Defense of Carcinogenesis by Stimulation of Toll-like Receptor (TLR), a Key Player of Innate Immune Responses Sung Yeon Kim*, Bo Yoon Chang and Bindu Malla Wonkwang University, Korea P1-219 Cordycepin-enriched Cordyceps Militaris Induces Immunomodulation and Tumor Growth Delay in Mouse-derived Breast Cancer Min Ho Jeong1, Kwang Mo Yang2, Yoo Jin Choi2 and Wol Soon Jo2* 1 Dong-A University, Korea, 2 Dong Nam Institute of Radiological & Medical Sciences, Korea P1-220 Curcumin Induced Expression of 15-Hydroxyprostaglandin Dehydrogenase in Normal Gastric Epithelial RGM-1 Cells and Mouse Stomach in Vivo: A Potential Role of AP-1 Ye-Sung Oh1, Jeong Hwa Woo1, Hye-Kyung Na1*, Ji-Hye Jang1, Jong-Min Park2 and Young-Joon Surh2 1 Sungshin Women's University, Korea, 2 Seoul National University, Korea P1-221 Oligonol Inhibits Dextran Sulfate Sodium-induced Colitis and Colonic Adenoma Formation in Mice Hye-Won Yum1, Xiancai Zhong1, Jin Park1, Hye-Kyung Na2, Nayoung Kim3, Hye Seung Lee3 and Young-Joon Surh1* 1 Seoul National University, Korea, 2 Sungshin Women's University, Korea, 3 Seoul National University Bundang Hospital, Korea P1-222 Curcumin Induces Apoptosis in H-Ras Transformed Human Mammary Epithelial Cells by Blocking STAT3 Signaling Young Il Hahn1, Su Jung Kim1, Bu Young Choi2, Hye-Kyung Na3 and Young Joon Surh1* 1 Seoul National University, Korea, 2 Seowon University, Korea, 3 Sungshin Women's University, Korea The XIII 64 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-223 Effect of Sophora Flavescens Extact on Blood Cells of 5'-Fluorouracil Injected Mice Boohyeong Byun1* and Yoo-Sik Yoon2 1 Daegu Haany University, Korea, 2 Chung-Ang University, Korea P1-224 Curcumin Destabilizes SIRT1 Protein through Dephosphorylation in Human Colon Cancer HCT-116 Cells Yeon-Hwa Lee, Na-Young Song and Young-Joon Surh* Seoul National University, Korea P1-225 Chemoprotective Effects of Antioxidants on Diethylhexyl Phthalate-induced Endocrine Disruption and their Mechanism of Action Seul Min Choi, Hyung Sik Kim and Byung Mu Lee* Sungkyunkwan University, Korea P1-226 Chemopreventive Effects of Chlorella vulgaris on Exposure to Carcinogenic Heterocyclic Amines and Polycyclic Aromatic Hydrocarbons Inyeong Lee and Mihi Yang* Sookmyung Women’s University, Korea P1-227 Effects of Korean Red Ginseng (Panax Ginseng Meyer) on Bisphenol a Exposure and Gynecologic Complaints Seok Young Yoo and Mihi Yang* Sookmyung Women's University, Korea P1-228 Tetrahydrocurcumin Potentially Protects against Oxidative Testicular Damage by Arsenic in Rats Muthu M Muthu and Milton P Selvaraj Annamalai University, India

P1-229 ~ 231 : Climate Change and Human Health P1-229 Effects of Fine Particulate Matter (PM2.5) During a Haze Episode on Mitochondrial Fusion/Fission of Alveolar Macrophages Hong Geng1*, Haiying Wei1, Ruijin Li1 and Chul-Un Ro2 1 Shanxi University, China, 2 Inha University, Korea P1-230 Multiple Gene Targeted Metagenomic Methods to Detect Potential Pathogenic Bacteria in Urban Bioaerosol Keunje Yoo1, Yun-Jung Han1, Lim-Seok Chang2 and Joonhong Park1* 1 Yonsei University, Korea, 2 National Institute of Environmental Research, Korea P1-231 Impact of Climate Change in Bangladesh: The Role of Two Governments Shakeel A Mahmood Bangladesh Environmental Improvement Committee, Bangladesh

P1-232 ~ 250 : Clinical Toxicology P1-232 An Unusual Cause of Seizure in a One-year Old Child: A Case Report of Camphor Poisoning Rizza Ann B Lio, Tisha Isabel Briola and Cariss Dioquino Philippine General Hospital, Philippines P1-233 Solid-phase Extraction with Liquid Chromatography and Ultraviolet Detection for the Assay of Morphine Ruzilawati Abu Bakar, Wan Nazirah Wan Yusuff, Norzihana Ramli, Zuliza Hussin and Aida Hanum Ghulam Rasool Universiti Sains Malaysia, Malaysia P1-234 Foundry Fumes Exposure and Chronic Obstructive Pulmonary Disease Frederic J Deschamps Medicine Faculty, France P1-235 Evaluation of Plasma Lead Concentration in Osteoporotic Patients by Anodic Stripping Voltametry Naﬁ ceh Sadeghi1, Mohammad Reza Oveisi1, Behrooz Jannat2, Fatemeh Sadeghi1, Mannan Hajimahmoodi1, Abdolazim Behfar3, Masoomeh Behzad1 and Golnaz Mohebzadeh1 1 Tehran University of Medical Sciences, Iran, 2 Ministry of Health and Medical Education, Iran, 3 Ahvaz Jondishapour University of Medical, Iran The XIII International Congress POSTER / JULY 1 (MON) 65 of Toxicology

P1-236 Torsades de Pointes Associated with Cesium Carbonate for Treatment of Cancer Mohammed A Aljumaan Dammam University, Saudi Arabia P1-237 Poison in the Condominium Adeline Ngo1* and Leo Seo Wei2 1 Alexandra Hospital, Juronghealth Services,, Singapore, 2 Dr Leo Adult & Paediatric Eye Specialist Pte Ltd Mt Elizabeth Medical Centre, Singapore P1-238 Lethality of Acute Poisonings in the Toxicology Clinic of Emergency Hospital “N.I.Pirogov” for the period 2009 - 2011 Julia V Radenkova-saeva Emergency Hospital 'Pirogov', Toxicology Clinic, Bulgaria P1-239 Marine Clinical Toxinology in Europe Luc Haro Marseille Poison Centre, France P1-240 Poisonings in Singapore: A Poison Center Perspective Ponampalam R* Singapore General Hospital, Singapore P1-241 Evaluation of Serum Sodium Changes in Tricyclic Antidepressants Toxicity and its Correlation with Electrocardiography, Serum pH, and Toxicity Severity Farzad Gheshlaghi1* and Gita Montazery Najaf Abadi2 1 Isfahan University of Medical Sciences, Iran, 2 Isfahan Centre of Legal Medicine, Iran P1-242 Outbreak of Methanol Poisoning in Central Europe in 2012 Daniela Pelclova*, Sergey Zakharov and Tomas Navratil Charles University, 1st Medical Faculty and General University Hospital, Czech P1-243 Methanol Outbreak in the Czech Republic In 2012: 120 Cases and 39 Deaths. Has It Been Different from 'Methanol Epidemies“ in Other European Countries? Sergey Zakharov1*, Daniela Pelclova2 and Tomas Navratil3 1 Czech Toxicological Information Center of General University Hospital and 1st School of Medicine UK, Czech, 2 General University Hospital, Czech, 3 J. Heyrovsky Institute of Physical Chemistry of AS CR, Czech P1-244 Severe Hypoglycemia in Acute Tramadol- overdosed Patients (Interim Report) Abdolkarim Pajoumand, Haleh Talaie, Soheil Nasouhi* and Mohsen Rezaei Hemami Toxicological Research Center,Shahid Beheshti University of Medical Sciences, Iran P1-245 Charcoal Burning Related Carbon Monoxide Poisoning in Taiwan Chen-Chang Yang1*, Ming-Ling Wu2, Jou-Fang Deng2 and Chun-Chi Lin2 1 National Yang-Ming University, Taiwan, 2 Veterans General Hospital, Taiwan P1-246 Identiﬁ cation of Novel Urinary Biomarkers as Surrogates of Acute Kidney Injury Following Human Self- Poisoning with a New Laundry Detergent in Southern Sri Lanka Thilini M Wijerathna1*, Dhammika M Dissanayake1, Fahim Mohamed1, Fathima Shihana1, Seyed Shahmy1, Chathura Palangasinghe1, Nick Buckley2 and Indika Gawarammana1 1 University of Peradeniya, Sri Lanka, 2 University of New South Wales, Australia P1-247 Toxicity due to Aging Affect of the Magnetic Nanoparticles and its Signiﬁ cant Role on the Biomedical Applications Anupati Telugu Raghavender1*, Nguyen Hoa Hong2 and Yin Hua Zhang2 1 Nishitha College of Engineering and Technology, India, 2 Seoul National University, Korea P1-248 High Dose Acrylamide-induced Purkinje Cell Damage, Fatal Case of Acrylamide Intoxication Satoshi Furukawa1, Satomu Morita1, Hayato Okunaga1, Lisa Wingenfeld2 and Katsuji Nishi1 1 Shiga University of Medical Science, Japan, 2 Munich University, Germany The XIII 66 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-249 A Case of Acute Prochloraz Manganese Complex Intoxication Treated with Extracorporeal Elimination Hyo-Wook Gil1, Su-Jin Seok1, Mihye Jeong2, Sae-Yong Hong1* and Jin Sun Kim1 1 Soonchunhyang University Cheonan Hospital, Korea, 2 Rural Development Administration, Korea P1-250 Effect of Intravenous Lipid Emulsion in Patients with Acute Glyphosate Intoxication Hyo-Wook Gil1*, Jae-Seok Park1, Sang-Ho Park1, Sae-Yong Hong1 and Su Kyung Kim2 1 Soonchunhyang University Cheonan Hospital, Korea, 2 Soonchunhyang University, Korea

P1-251 ~ 254 : Computational Toxicology P1-251 Reﬁ ned Animal Toxicity Testing using Unequally Sized Dose Groups and Benchmark Dose Analysis Gunnar Johanson*, Joakim Ringblom, Fereshteh Kalantari and Mattias Oberg* Institute of Environmental Medicine, Karolinska Institutet, Sweden P1-252 Challenges in Predicting Mixture Toxicity using Computational Toxicology Methods: Toward Integrated Environmental Hazard Assessment Jongwoon Kim1*, Sanghun Kim1 and Gabriele E Schaumann2 1 Korea Institute of Science and Technology Europe, Germany, 2 University of Koblenz-Landau, Germany P1-253 Modelling and Analysis of Daphnia Energy Budget Dynamics in Response to Malathion Chronic Exposure Baba Issa Camara, Hela Toumi and Jean-Fancois Ferard Lorraine University, France P1-254 Giving Conﬁ dences for in Silico GTI Assessments Laurence Coquin, Chris G Barber, Philip N Judson, Susanne A Stalford, Jonathan D Vessey and Richard V Williams Lhasa Limited, United Kingdom

P1-255 ~ 259 : Cosmetics and Safety P1-255 Hair Dyes Brand Royal Henna “Royal Henna”: Voluntary Ingestion and Clinical Manifestation Rajaa Bellaje1*, Houda Sefi ani2, Doha Ben Ali1, Abdelmajid Soulaymani1 and Rachida Soulaymanii Bencheikh2 1 University Ibn Tofail, Morocco, 2 Anti-poisoning and Pharmacovigilance Center, Morocco P1-256 Risk Assessment Process in Cosmetics Seoyoung Kim and Kyeho Shin* AmorePacifi c Corporation R&D Center, Korea P1-257 New Anti-dandruff Shampoo Containing Zinc Pyrithione and Rose Extract for Asian Yun Hyeok Jeong, Jeong Hwan Kim, Byeong Ha Kang and John Hwan Lee* Amorepacifi c R&D Center, Korea P1-258 Anti-infl ammatory, Antifungal and Lipid-reducing Effect of Rosa Centifolia Extract for the Treatment of Seborrheic Dermatitis Jeong-Hwan Kim, Yun-Hyeok Jeong, Hyun Gee Lee, Ah-Reum Kim, Yeon Su Jeong and Hong-Ju Shin* Amorepacifi c R&D Center, Korea P1-259 In Vitro and in Vivo Percutaneous Absorption of Benzophenone-3 from Sunscreen Formulations in Rats Tae Hwan Kim1, Sungha Ryu2, Beom Soo Shin3, Sung Dong Yoo1 and Kyu-Bong Kim2* 1 Sungkyunkwan University, Korea, 2 Dankook University, Korea, 3 University of Daegu, Korea

P1-260 ~ 286 : Development and Reproductive Toxicology P1-260 Environmental Contaminant Bisphenol a Toxicity Study in Swiss Albino Mice Model Sameya Anjum Jamia Hamdard, India P1-261 The Neurodevelopmental Toxicity of Epigallocatechin Gallate (EGCG): in Vitro and in Vivo Effects Kathrin Gassmann1, Christine Baksmeier1, Sabrina Heinz1, Maria T Colomina2, Ingrid Reverte2, Marta Barenys1 and Ellen Fritsche1 1 IUF - Leibniz Research Institiute of Environmental Medicine, Germany, 2 Psychobiology Unit, School of Psychology, ‘‘Rovira i Virgili’’ University, Spain The XIII International Congress POSTER / JULY 1 (MON) 67 of Toxicology

P1-262 Testicular Toxicity of a Commercial Polyherbal Product in Male Albino Rats Emmanuel U Etuk Usmanu Danfodiyo University, Nigeria P1-263 Effect of Electromagnetic Field Exposure on the Testis and Ovary of Mice Nihayah - Mohammad*, Sim Pei Ling and Nor Fadilah Rajab Universiti Kebangsaan Malaysia, Malaysia P1-264 Effects of Monobutyl Phthalate on Steroidogenesis through Steroidogenic Acute Regulatory Protein Regulated by Transcription Factor in Mouse Leydig Tumor Cells Yanhui Hu, Congcong Dong, Minjian Chen, Aihua Gu, Yankai Xia, Zhong Li, Xiumei Han and Yubang Wang* Nanjing Medical University, China P1-265 The Effect of Dofetilide on Heart Rate in the Developing Rat Embryo in Vivo Helen Ritchie1, Tzong-Tyng Hung2 and Elizabeth Hegedus1 1 University of Sydney, Australia, 2 University of New South Wales, Australia P1-266 Critical Roles of Sertoli Cells in PFOS-induced the Reduction of Spermatogenesis in Mice Lianglin Qiu, Xuhui Zhang, Jun Gu, Zhan Zhang, Xinru Wang and Shou-Lin Wang* Nanjing Medical University, China P1-267 A Comparative Study on Embryo-Fetal Development Toxicity of Benzo[a]pyrene between Crl:CD(SD) Rats and Crl:WI(Han) Rats Maki Maeda1, Tohru Sekido2, Hiroshi Mineshima2, Shoji Asakura1, Satoru Hosokawa1 and Kazuo Tsukidate1 1 Eisai Co., Ltd., Japan, 2 Sunplanet Co., Ltd., Japan P1-268 An Establishment of in Vitro Developmental Neurotoxicity Evaluation Method using the Cell Line Derived from PC-12 Kohei Hoshino, Jiro Deguchi*, Maki Hashimoto*, Izuru Miyawaki*, Juki Kimura and Hitoshi Funabashi Dainippon Sumitomo Pharma Co., Ltd., Japan P1-269 Exposure to DEHP in the Pregnant Mice May Suppress the Amount of Food Intakes of Offspring in the Development Stage Yumi Hayashi1, Yuki Ito2, Hisao Naito1, Takaaki Kondo1, Michihiro Kamijima2 and Tamie Nakajima3* 1 Nagoya University Graduate School of Medicine, Japan, 2 Nagoya City University Graduate School of Medicine, Japan, 3 Chubu University College of Life and Health Sciences, Japan P1-270 Minipigs as a Non-rodent Species for Embryofetal Development Studies Andrew Makin1, Thomas K Andreassen1, Paul C Barrow2 and Roy Forster2 1 CiToxLAB Scantox, Denmark, 2 CiToxLAB France, France P1-271 A Weight of Evidence Evaluation for Reproductive and Developmental Toxicity Classiﬁ cation of Boric Acid R. Wayne Ball1 and Pauline Hee2 1 Rio Tinto Minerals, USA, 2 Rio Tinto Minerals, Singapore P1-272 Comparison of Blood, Semen and Testes Boron Levels in Human and Rat: Relevance for Toxicity Classiﬁ cation of Boric Acid R. Wayne Ball1 and Pauline Hee2 1 Rio Tinto Minerals, USA, 2 Rio Tinto Minerals, Singapore P1-273 Changes in Methylmercury Uptake into the Brain at Various Growth Phases of Rats through Fetus to Adult Mineshi Sakamoto1*, Akiyoshi Kakita2 and Hing M Chan3 1 National Institute for Minamata Disease, Japan, 2 Niigata University, Japan, 3 University of Ottawa, Canada P1-274 Optimization of Reproductive and Developmental (R/D) Toxicity Assessment using Primary Neonatal Rat Testicular Co-cultures Ju Young Park*, Susanna Wegner, Sean Harris, Sungwoo Hong and Elaine M Faustman* University of Washington, USA P1-275 Predicting Embryotoxicity Using Gene Expression as Biomarker of Alterations in Differentiation after only 5 Days of Exposure in mouse in Vitro Embryonic Stem Cells Miguel Angel Sogorb, Carmen Estevan, David Pamies, Carmen Estevan, Iris Mangas, Jorge Estevez, Eugenio Vilanova* and Andrea C Romero University Miguel Hernandez of Elche, Spain The XIII 68 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-276 Chlormequat Chloride Could Retard Rat Embryo Growth in Vitro in a Non-Cytotoxic Way Bayindala Xiagedeer, Shuang Wu, Yingjuan Liu, Xuexian Zhou and Weidong Hao* Peking University Health Science Center, China P1-277 Protective Effect of Testosterone Propionate on Reproductive Toxicity in Male Mice Caused by Endosulfan Xian-Ging Zhou* Capital Medical University, China P1-278 The Japanese Existing Chemical Safety Survey Program : Reproductive Toxicity of 3-Cyanopyridine in Rats Atsushi Ono1*, Mika Takahashi1, Kaoru Yabe2, Hina Kato1, Tomoko Kawamura1, Mariko Matsumoto1, Mutsuko Hirata-Koizumi1 and Akihiko Hirose1 1 National Institute of Health Sciences, Japan, 2 Safety Research Institute for Chemical Compounds Co., Ltd., Japan P1-279 miRNA Expression Proﬁ ling and 3D Neuronal Differentiation of LUHMES Progenitor Cells as an in Vitro Model for Developmental Neurotoxicity (DNT) Assessment Lena Smirnova, Georgina Harris, Helena Hogberg, Suzanne Martos and Thomas Hartung Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, USA P1-280 The Assessment of the Embryotoxic Chemicals by using Human Embryonic Stem Cells Eui-Man Jung, Yeo-Ul Choi, Hong-Seok Kang and Eui-Bae Jeung* Chungbuk National University, Korea P1-281 Effects of Developmental Toxic Chemicals on Cardiomyocyte Differentiation of Mouse Embryonic Stem Cell Yeoul Choi and Eui-Bae Jeung* Chungbuk National University, Korea P1-282 Assessment of Drug Induced Developmental Neurotoxicity using Human Embryonic Stem Cells Hong-Seok Kang and Eui-Bae Jeung* Chungbuk National University, Korea P1-283 Correlation between Blood Mercury and Serum Human Placental PRL-GH Family Hormone Concentrations Chae Kwan Lee* and Jong Tae Lee Inje University, Korea P1-284 Perﬂ uorooctane Sulfonate Inhibits the Placental PRL-GH Gene Expression and Retards Placental and Fetal Growth in Mice Chunhui Suh, Chae Kwan Lee* and Jong Tae Lee Inje University, Korea P1-285 Mothers and their Infants’ Health from Gestational Exposure to the Hebei Spirit Oil Spill Hyun S Bae1, Su Ryeon Noh1, Gwi Heum Eom1, Jung Ah Kim1, Seon Young Ka1, Young-Hyun Choi1, Mina Ha2*, Hae-Kwan Cheong3* and Eun-Hee Ha4* 1 Taean Environmental Health Center, Korea, 2 Dankook University College of Medicine, Korea, 3 Sungkyuonkwan University School of Medicine, Korea, 4 Ewha Womans University School of Medicine, Korea P1-286 Child Developmental Toxicity of Mixture Chemical Exposure from E-waste Recycling Xia Huo* and Xijin Xu Shantou University Medical College, China

P1-287 ~ 291 : DNA Replication and Repair P1-287 Histone Methyltransferase G9a Promotes the Oral Cancer Cells Recovery from Drug-induced DNA Damage Shih-Ting Cha, Chia-Wen Liu and Min-Liang Kuo* National Taiwan University College of Medicine, Taiwan P1-288 The Association between BRCA1 and BRCA2 is Required for DNA Double Strand Breaks Repair Chao Dong and Zhihui Feng* Shandong University, China P1-289 Biochemical Characterization of Eight Variants of Human DNA Polymerase Kappa Involved in Translesion DNA Synthesis Insil Song1, Eun-Jin Kim1, F. Peter Guengerich2 and Jeong-Yun Choi1* 1 Sungkyunkwan University School of Medicine, Korea, 2 Vanderbilt University School of Medicine, USA The XIII International Congress POSTER / JULY 1 (MON) 69 of Toxicology

P1-290 Biochemical Characterization of Natural Genetic Variants of Human DNA Polymerae Iota Jinsook Kim1, Insil Song1, Ara Jo1, Robert L. Eoff2, F. Peter Guengerich3 and Jeong-Yun Choi1* 1 Sungkyunkwan University School of Medicine, Korea, 2 University of Arkansas for Medical Sciences, USA, 3 Vanderbilt University School of Medicine, USA P1-291 Modulatory Role of Thioredoxin-1 in Base Excision Repair under Redox Modulation Hye Lim Kim and Young Rok Seo* Dongguk University, Korea

P1-292 ~ 314 : Drug Induced Toxicity P1-292 The Wound Healing Process and the Anti-epidermal Growth Factor/Epidermal Growth Factor Receptor Therapeutic Anti-cancer Drugs Angel C Parada1, Dasha Fuentes2, Nuris Ledon3, Aymara Fernandez3 and Tania Crombet3 1 Center for Molecular Immunology, Cuba, 2 CENPALAB, Cuba, 3 CIM, Cuba P1-293 Effects of Antiretroviral Drugs on the Release of Pro-inﬂ ammatory Mediators by Human Endothelial Cells Carman Lo*, Shui S Lee, George P Leung and Susan W Leung The University of Hong Kong, Hong Kong P1-294 Study on the Toxicity of Rhubarb and its Major Constituents Quanjun Wang Beijing Institute of Pharmacology and Toxicology, China P1-295 Protective Mechanism of Garlic Oil in Rifampicin-isoniazid Induced Hepatotoxicity in Rats Xiaoying Shao1, Mingxing Zhu1, Wenting Wang2, Tao Zeng1, Hua Yuan1 and Keqin Xie1* 1 Shandong University, China, 2 Weihai Municipal Hospital, China P1-296 Hypersusceptibility Study of Breviscapine Injectas Wei Y Luo, Yong Wang, Rong Wang, Juan Jiang, Li Zhou and Yue Z Sun* Shanghai Institute of Planned Parenthood Research, China P1-297 A Screening for Essential Cell Growth-related Genes Involved in Adriamycin Resistance in Saccharomyces Cerevisiae Zhu Junxuan, Nakashima Shingo, Takahashi Tsutomu and Naganuma Akira* Tohoku University, Japan P1-298 The Effect of Ageing on Paracetamol Pharmacokinetics and Toxicity in Fischer 344 Rats John Mach1, Aniko Huizer-Pajkos2, Victoria C Cogger3, Catriona Mckenzie4, David G Le Couteur3, Brett Jones1 and Sarah N Hilmer1 1 Royal North Shore Hospital and Sydney Medical School, Australia, 2 Kolling Institute of Medical Research and Royal North Shore Hospital, Australia, 3 Concord Hospital and University of Sydney, Australia, 4 Royal Prince Alfred Hospital, Australia P1-299 Biodistribution and Predictive Hepatic Gene Expression of Intravenous Iron Sucrose Roy Forster1*, Johanne Bouchard1, Leonore Jaillet1, Nick Pearson1, Alexandra Rogue1, Caroline Sabadie1 and Peter Elford2 1 CiToxLAB France, France, 2 Azad Pharma AG, Switzerland P1-300 Histological Alterations in the Epididymal Tissue Induced by Sildenaﬁ l Overdoses Bashir M Jarrar Al-Jouf University, Saudi Arabia P1-301 Acute and Repeated Dose Toxicity Studies of Novel Pyridazinone Derivatives as New Class of Antihypertensive Agent Ravinesh Mishra1*, Anees A Siddiqui2, Asif Husain2, Mohd Rashid2 and Sameya Anjum2 1 Baddi University of Emerging Sciences & Technology, India, 2 Jamia Hamdard (Hamdard University), India P1-302 Synthesis of Benzimidazoles Bearing Oxadiazole and Triazolo-thiadiazoles Nucleous: As New Anticancer Agents Mohd Rashid*, Ravinesh Mishra, Asif Husain and Sameya Anjum Jamia Hamdard, India P1-303 Involvement of ERM Proteins and RhoA/ROCK Signaling in the Mechanism by which Etoposide, an Anti- cancer Drug, Up-regulates P-glycoprotein in the Small Intestine Takuro Kobori, Shinichi Harada, Kazuo Nakamoto and Shogo Tokuyama* Kobe Gakuin University, Japan The XIII 70 POSTER / JULY 1 (MON) International Congress of Toxicology

P1-304 Inhibition of JNK Activation Pathway Suppressed the EGFR Tyrosine Kinase Inhibitors-induced Keratinocyte Cytotoxicity Kai-Chun Li, Yi-Shuan Sheen, Ping-Chun Chen, James Chih-Hsing Yang, Chia-Yu Chu* and Kuo-Min Liang* National Taiwan University College of Medicine, Taiwan P1-305 The Cytotoxicity of the EGFR Tyrosine Kinase Inhibitors on Dermal Microvascular Endothelial Cells Chia-Wen Liu National Taiwan University, Taiwan P1-306 Study of Benzimidazoles Clubbed with Oxadiazole: Searching for New Anticancer Agents Mohd Rashid1*, Asif Husain1, Sameya Anjum1 and Ravinesh Mishra2 1 Jamia Hamdard, India, 2 Baddi University, India P1-307 A Four Week Repeated Study of Intravenous Toxicity of Recombinant Human Interleukin-2 Sprague-Dawley Rats Mi Ju Lee1, Sun Hee Park1, Myoung Jun Kim1, Hye-Jin Kim2, Yinghua Li1, Kyeoung-Nam Ko1, Duyeol Kim1, Yong-Hoon Lee1, Sun- Hee Kim1, Ho-Song Jang1, Yeongjun Baik3, Sunghee Lee3, Jin Seok Kang4* and Jong-Koo Kang2* 1 Biotoxtech Co. Ltd., Korea, 2 Chungbuk National University, Korea, 3 BMI Korea, Korea, 4 Namseoul University, Korea P1-308 90-day Repeated Dose Toxicity and Genotoxicity Tests of Coptis Chinensis in F344 Rats Myoung Jun Kim1, Yong-hoon Lee1, Mi Ju Lee1, Duyeol Kim1, Sun Hee Park1, Hye-Yeong Lee1, Mi-Young Lee1, Beom Seok Han2, Min Kwon2, Woo Chan Sohn3, Ji Hyeon Seok4, Jong Kwon Lee4, Jayoung Jeong4, Jin Seok Kang5* and Jongkoo Kang6* 1 Biotoxtech Co., Ltd., Korea, 2 Hoseo University Biomedical Laboratory Science, Korea, 3 Asan Medical Center, Korea, 4 National Institute of Food and Drug Safety Evaluation, KFDA, Korea, 5 Namseoul University, Korea, 6 Chungbuk National University, Korea P1-309 Doxorubicin-induced Platelet Procoagulant Activities: An Important Clue for Chemotherapy-associated Thrombosis Se-Hwan Kim1, Kyung-Min Lim2, Ji-Yoon Noh1, Keunyoung Kim1, Seojin Kang1 and Jin-Ho Chung1* 1 Seoul National University, Korea, 2 Ehwa Womans University, Korea P1-310 Identifi cation of Modulated mRNAs and Proteins in Human Primary Hepatocytes Treated by Non-steroidal Anti-infl ammatory Drugs Jae-Young Jeong, Min-Gyeong Park, Joon-Ik Ahn, Yang-Jin Hyun, Hyun Uk Kim, Ho-Sang Jeong, Eun-Jung Kim, Soon Young Han and Hoil Kang* National Institute of Food and Drug Safety Evaluation, Korea P1-311 Dysfunction of Vascular Smooth Muscle and Vascular Remodeling by Simvastatin Seojin Kang1, Kyung-Min Lim2, Keunyoung Kim1, Ok-Nam Bae3 and Jin-Ho Chung1* 1 Seoul National University, Korea, 2 Ehwa Womans University, Korea, 3 Hanyang University, Korea P1-312 A Study on the Identifi cation of Intestinal Integrity Biomarkers following Cancer Chemotherapeutic 5-fl uorouracil Treatment in BALB/c Mice Minkyung Song, Jooyeon Park, Sujeng Lee and Mi-Kyung Sung* Sookmyung Women’s University, Korea P1-313 The Effects of Orotic Acid on the Regulation of Endothelial Nitric Oxide Synthase You-Jin Choi, Yujin Yoon, In-Hoi Han, Tran Thi Hien, Keon Wook Kang and Byung-Hoon Lee* Seoul National University, Korea P1-314 Uric Acid Induces Endothelial Dysfunction and Hypertension through Vascular Insulin Resistance You-Jin Choi, Yujin Yoon, In-Hoi Han, Tran Thi Hien, Keon Wook Kang, Jiwoo Lee and Byung-Hoon Lee* Seoul National University, Korea The XIII International Congress POSTER / JULY 2 (TUE) 71 of Toxicology

P2-001 ~ 015 : Drug Metabolizing Enzymes P2-001 Effects of Active Constituents and Extracts of Curcuma Xanthorrhiza on Glutathione Transferase Activity Nurul Afi fah Mohd Salleh, Mohd Rohaimi Abdul Halim and Sabariah Ismail* Centre for Drug Research, Universiti Sains Malaysia, Malaysia P2-002 Effects of Glucosamine, Chondroitin and Diacerein on Human Hepatic Cytochrome P450 3A4 Activity in vitro Boon Hooi Tan1, Yan Pan2, Uma Devi Palanisamy1, Iekhsan Othman1, Beow Chin Yiap2 and Chin Eng Ong1* 1 Monash University Sunway Campus, Malaysia, 2 International Medical University, Malaysia P2-003 Simultaneous Determination of Cathinones and Their Metabolites in Urine by GC-MS-MS Mei-Chun Liu, Hsiang-Ping Hsu and San-Chong Chyueh* Investigation Bureau, Ministry of Justice, Taiwan P2-004 Detoxifi cation of Menadione through NQO1 Reduction Followed by Glucuronidation Takahito Nishiyama, Tomokazu Ohnuma, Kenichiro Ogura and Akira Hiratsuka* Tokyo University of Pharmacy and Life Sciences, Japan P2-005 Augmentation of AhR-mediated Induction of CYP1A Subfamily Enzymes by Nicardipine in Human Hepatoma-derived Cell Lines and Rat Tissues Masashi Sekimoto*, Takuomi Hosaka, Ayaka Kamoshita and Masakuni Degawa School of Pharmaceutical Sciences, University of Shizuoka, Japan P2-006 Extrahepatic Metabolism in Humans Christine Jackh and Ursula Gundert- Remy* German Society of Toxicology (GT), Mannheim and Berlin, Germany P2-007 The Cytochrome P450 2C9*35 Allele Is Catalytically Silent due to the Nonfunctional Interaction with Cytochrome P450-NADPH Reductase Mi-Young Lee1, Souren Mkrtchian1, Inger Johansson1, Paola Borgiani2, Mattia Falconi2 and Magnus Ingelman-Sundberg1* 1 Karolinska Institutet, Sweden, 2 University of Rome Tor Vergata, Italy P2-008 Metabolite Identifi cation of Rutaecarpine in Freshly Isolated Rodent Hepatocytes Tae Cheon Jeong*, Do Gyeong Oh, Jin Sung Kim, Chae Shin Seo, Yeon Ji Um, Yurngdong Jahng and Mi Jeong Kang Yeungnam University, Korea P2-009 Effects of Intestinal Microfl ora on Oral Pharmacokinetics of Baicalin in Mice Do Gyeong Oh, Jin Sung Kim, Chae Shin Seo, Yeon Ji Um, Mi Jeong Kang, Wonku Kang and Tae Cheon Jeong* Yeungnam University, Korea P2-010 Effects of Intestinal Microfl ora on Oral Pharmacokinetics of Baicalin in Germ-free Mice Jin Sung Kim1, Do Gyeong Oh1, Mi Jeong Kang1, Won Ki Yun2, Hyoung Chin Kim2 and Tae Cheon Jeong1* 1 Yeungnam University, Korea, 2 Korea Research Institute of Bioscience & Biotechnology, Korea P2-011 Effects of Metabolism by Intestinal Microfl ora in Geniposide-induced Toxicity in HepG2 Cell Cultures Chae Shin Seo1, Hyung Gyun Kim2, Jin Sung Kim1, Do Gyeong Oh1, Mi Jeong Kang1, Hye Gwang Jeong2 and Tae Cheon Jeong1* 1 Yeungnam University, Korea, 2 Chungnam National University, Korea P2-012 Effects of Metabolism by Intestinal Microfl ora on Oral Pharmacokinetics of Baicalin in Rats Yeon Ji Um, Gyu Sub Ko, Jin Sung Kim, Do Gyeong Oh, Mi Jeong Kang and Tae Cheon Jeong* Yeungnam University, Korea P2-013 Arbutin-induced Immunotoxicity via Metabolism by Intestinal Bacteria to Hydroquinone in Vitro Mi Jeong Kang1, Do Gyeong Oh1, Jin Sung Kim1, Young Tae Ahn2, Dong Hyun Kim3 and Tae Cheon Jeong1* 1 Yeungnam University, Korea, 2 Yakult Company, Korea, 3 Kyung Hee University, Korea P2-014 Docking Analysis of Selective Combinatorial Drugs with Cytochrome P450 in Cancer Therapy Suresh Panneerselvam, Shaherin Basith and Sangdun Choi* Ajou University, Korea The XIII 72 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-015 Difference of Epoxide Hydrolase and Phosphatase Activities in the Polymorphic Variants of Human Soluble Epoxide Hydrolase Endang R Purba, Ami Oguro and Susumu Imaoka* Kwansei Gakuin University, Japan

P2-016 ~ 038 : Ecotoxicology P2-016 Physical, Chemical and Biological Atoyac River Water in the Watershed of the Sierra del Tentzo State Reserve and its Environmental Impact. Puebla, Mexico Anabella H Silva, Yesenia R Lopez, Moises C Montiel, Lucia L Reyes, Carolina M Raya, Ernesto M Ramirez and Sonia S Gomez Benemerita Universidad Autonoma de Puebla, Mexico P2-017 Integral Rescue Metapan Lagoon of Elsalvador Anabella H Silva1, Yesenia R Lopez1, Moises C Montiel1, Lucia L Reyes1, Carolina M Raya1, Rodolfo F Menjivar2 and Zoila G Mendoza2 1 Benemerita Universidad Autonoma de Puebla, Mexico, 2 Universidad de El Salvador, El Salvador P2-018 Mortality in Hill Stream Fishes After Solar Ultraviolet Radiation in Himalayan Region India Sunil Kumar D. A. V. (P. G.) College Dehradun, India P2-019 Counteracting Roles of Thromboxane and Prostacyclin in Precardiac Edema Formation in Developing Zebrafi sh Exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin Hiroki Teraoka*, Yuki Okuno, Daisuke Nijoukubo, Ayumi Yamakoshi and Takio Kitazawa Rakuno Gakuen University, Japan P2-020 Metabolic and Immunological Responses of Juvenile Australian red Claw Crayfi sh Cherax Quadricarinatus to Nitrite at Different Chloride Levels Qi-Chen Jiang, Jia-Xin Yang* and Teng-Jiao Kuang Nanjing Normal University, China P2-021 Effi ciency of Miscanthus Giganteus for the Phytomanagement of Agricultural Fields located near the Metaleurop Nord Smelter (Noyelles-Godault, North of France) Verdin Anthony1*, Firmin Stephane1, Philibert Emilie1, Lopareva-Pohua Alena2, Billet Sylvain1, Pourrut Bertrand2, Douay Francis2 and Shirali Pirouz1 1 Universite du Littoral Cote d'Opale, France, 2 Groupe ISA, France P2-022 Evaluation of Potential Ecotoxicity Effects of Newly Developed Friction Composite Materials for Automotive Brake Linings Katerina Malachova1, Hana Sezimova1*, Jiri Cerven1, Zuzana Rybkova1, Jana Kukutschova2, Vlastimil Matejka2 and Petr Filip3 1 University of Ostrava, Czech, 2 VSB - Technical University Ostrava, Czech, 3 Southern Illinois University Carbondale, USA P2-023 Microbial Speciation of Arsenic in the Environment: Role of Bacterial Genetic Systems in Ground Water Arsenic Contamination Nandana Das and Ashok Giri CSIR-Indian Institute of Chemical Biology, India P2-024 In Vitro Approach to Predict AHR-mediated CYP1A Induction by Dioxins in Cormorant Population Hisato Iwata1*, Leena Mol Thuruthippallil1, Akira Kubota2 and Eun-Young Kim3 1 Center for Marine Environmental Studies, Ehime University, Japan, 2 Biology Department, Woods Hole Oceanographic Institution, USA, 3 Kyung Hee University, Korea P2-025 In Silico Analysis of Avian AHRs to Decipher the Molecular Basis for Interspecies Differences in Responses to Dioxins Masashi Hirano1, Su-Min Bak2, Hisato Iwata1 and Eun-Young Kim2* 1 Center for Marine Environmental Studies (CMES), Ehime University, Japan, 2 Kyung Hee University, Korea P2-026 The Importance of the Ecotoxicological Assessment for the Risk Management of Cosmetic Ingredients Cyro H Zacarias*, Karen Assanome and Diana D Queiroz Natura Inovacao e Tecnologia de Produtos Ltda, Brazi The XIII International Congress POSTER / JULY 2 (TUE) 73 of Toxicology

P2-027 Structure Determination and Evaluation of The Ecotoxicity of Acetaminophen Photoproduct by Ultraviolet Irradiation Kohei Kawabata1, Kazumi Sugihara2*, Seigo Sanoh1, Shigeyuki Kitamura3 and Shigeru Ohta1 1 Hiroshima University, Japan, 2 Hiroshima International University, Japan, 3 Nihon Pharmaceutical University, Japan P2-028 Levels of Copper (Cu), Zinc (Zn), Lead (Pb) and Arsenic (As) in Snail Species from Selangor, Malaysia Rina Sharlinda S Zabri Universiti Putra Malaysia, Malaysia P2-029 Occurrence of Cyanobacteria and Microcystins from dau tieng Reservoir, Vietnam, and their Toxicity to Zebra Fish Son T Dao Institute for Environment and Resources, Viet Nam P2-030 Simvastatin Effects in Danio Rerio Embryos: Gene Expression Analysis of Detoxifi cation Mechanisms Virginia Cunha CIIMAR- Centro Interdisciplinar de Investigacao Marinha e Ambiental, Portugal P2-031 Growth Inhibition of Soil Alga Chlorococcum Infusionum in Soils Polluted by Heavy Metals Sun-Hwa Nam and Youn-Joo An* Konkuk University, Korea P2-032 Ecotoxicity Evaluation of Organic Agro-materials Containing Pepper Extract, Cassia Oil and Lavender Oil for Control of Diamondback Moth Are-Sun You, Soon-Sung Hong, Mihye Jeong, Kyung-Hun Park, Jae-Eup Park and Je Bong Lee National Academy of Agricultural Science, Korea P2-033 Identifi cation of Novel Aryl Hydrocarbon Receptor Isoform in Fire-bellied Toad Bombina Orientalis (Boulenger) Jihee Hwang and Eun-Young Kim* Kyung Hee University, Korea P2-034 Effects of Bisphenol A Exposure in Earthworm by 1H NMR-based Metabolomics Dahye Yoon and Suhkmann Kim* Pusan National University, Korea P2-035 1H NMR-based Metabolomics of Zebrafi sh Exposed to Heavy Metals Minji Lee and Suhkmann Kim* Pusan National University, Korea P2-036 The Primary Toxic Effects on Marine Embryonic Fish from Oil Exposure; Different Toxic Sensitivity between Flounder (Paralichthys Olivaceus) and Spotted Sea Bass (Lateolabrax Maculates) Jee Hyun Jung*, Young Sun Chae and Ha Na Kim Korea Institute of Ocean Science & Technology(KIOST), Korea P2-037 Effect of Long Term Exposure to Mefenamic Acid on Aquatic Organisms Daphnia Magna, Moina Macrocopa and Danio Rerio Hyo-Rin Jung1, Seungeun Kang2, Sangwoo Lee2, Kyunghee Ji2, Younglim Kho3, Byeongwoo Ahn4, Jisung Ryu5, Jaean Lee5, Kyungho Choi2* and Hea-Young Cho1* 1 CHA University, Korea, 2 Seoul National University, Korea, 3 Eulji University, Korea, 4 Chugbuk National University, Korea, 5 National Institute of Environmental Research, Korea P2-038 Assessing Photosynthetic Activity and Growth Yield of Chlorococcum Infusionum Exposed to Heavy Metals Sun-Hwa Nam and Youn-Joo An* Konkuk University, Korea

P2-039 ~ 055 : Endocrine Disrupting Chemicals P2-039 Study the Regulation Mechanisms of BPA on Steroidogenesis in Placental JEG-3 Cell Zhi-Jie Yang, Yi-Een Lin and Hsin-Chieh Lan* National Defense Medical Center Institute of Biology and Anatomy, Taiwan The XIII 74 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-040 Acute Toxicity of 4-Nonylphenol Isomers to Larval Medaka Koji Arizono*, Chenfu Sun, Henze Ji, Jun Kobayashi and Minoru Koga Prefectural University of Kumamoto, Japan P2-041 In Vivo Proﬁ ling of 2,3,7,8-tetrachrolodibenzo-p-dioxin-induced Estrogenic/anti-estrogenic Action in Female Using Estrogen Reporter (E-Rep) Mice Tsuyoshi Nakanishi*, Ichiro Yoshida, Hiroshi Yoshikawa, Sho Kitamura and Hisamitsu Nagase Gifu Pharmaceutical University, Japan P2-042 Possible Aryl Hydrocarbon Receptor-independent Pathway of 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced Antiproliferative Response in Human Breast Cancer MCF-7 Cells Hiroki Yoshioka1, Youhei Hiromori1, Akira Aoki1, Tomoki Kimura2, Yoshiaki Fujii-Kuriyama3, Hisamitsu Nagase1 and Tsuyoshi Nakanishi1* 1 Gifu Pharmaceutical University, Japan, 2 Setsunan University, Japan, 3 Tokyo University, Japan P2-043 High-throughput Screening (HTS) of Bisphenol A (BPA) in Canned Food Supernatants by ELISA Sohee Kim1, Aby Joiakim2, David Kaplan2, Klaus Friedrich2, David Putt2 and Hyesook Kim2* 1 Ajou University, Korea, 2 Detroit R&D, Inc., USA P2-044 Estimation of Benchmark Dose for Relative Thyroid Gland Weight in Rats Subacutely Exposed to Polychlorinated Biphenyls Vesna Matovic1, Aleksandra Buha1, Biljana Antonijevic1 and Vesna Milovanovic2 1 Faculty of Pharmacy, Department of toxicology 'Akademik Danilo Soldatovic', Serbia, 2 Serbian Chemical Agency, Serbia P2-045 Phthalates are Toxic for Male Infertility: Myth or Truth? Rashmi T Rana1, Arun K Jain1* and Nayan K Mohanty2 1 National Institute of Pathology (ICMR) Safdarjang Hospital, India, 2 Safdarjung Hospital, India P2-046 Modulation of Growth and Cell Cycle Progression in Breast Cancer Cells Following Exposure to Mycotoxins Zearalenone and Aﬂ atoxin B1 in Vitro Ka Yiu Yip, Alice S Wong and Hani El-Nezami* The University of Hong Kong, Hong Kong P2-047 Exposure to Low Dose di(2-ethylhexyl)phthalate in Early Life Stage associated with the Metabolic Disorder in Adulthood Yun-Jung Yang1, Yeon-Pyo Hong2*, Moon-Seo Park1, Sang-Yon Kim2 and Jihyun Ahn2 1 Incheon St. Mary’s Hospital, Korea, 2 Chung-Ang University, Seoul P2-048 Exposure to Triclosan Resulted in the Growth and Metastasis of Breast Cancer Cells via an Estrogen Receptor Alpha-mediated Signaling Pathway in a Xenograft Mouse Model Bearing Breast Tumor Hye-Rim Lee and Kyung-Chul Choi* Chungbuk National University, Korea P2-049 Effects of Phthalate on Prostate Cancer Growth and Alteration of Gene Expression related with Transforming Growth Factor-beta Signal via Estrogen Receptor and Androgen Receptor Signaling Pathways Hye-Rim Lee, Seung-Hee Kim and Kyung-Chul Choi* Chungbuk National University, Korea P2-050 Exposure to Octylphenol Induced the Severe Disruption of Cell Cycle Regulation of Breast Cancer Cells in a Cellular and a Xenograft Mouse Model Yong-Sub Byun, Hye-Rim Lee, Ye-Seul Kim and Kyung-Chul Choi* Chungbuk National University, Korea P2-051 Characterization and Development of Stable cell line with an Androgen-Responsive Luciferase Reporter Gene to Detect Androgen Receptor Agonists and Antagonists Yun-Ho Choi1, Hyun Ku Kang1, Young In Park1, Sang-Yub Kim2, Young-Mi Jang2 and Mi-Sook Dong1* 1 Korea University, Korea, 2 Institute of Food and Drug Safety Evaluation, Korea P2-052 Impaired Reproductive Organ Development of Offspring Maternally Exposed to Simazine Ho-Oak Park, Sa-Rang Kim and Jeehyeon Bae* Chung-Ang University, Korea The XIII International Congress POSTER / JULY 2 (TUE) 75 of Toxicology

P2-053 Prenatal Exposure to di(2-ethylhexyl) Phthalate and Effects of Lipid Metabolism in a Human Neonatal Panel Hyunkyung Park1, Jangwoo Lee1, Jeong-Jae Lee2, Gyuyeon Choi2, Sungjoo Kim3, Sooran Choi3, Hae-Joong Kim4, Geumjoon Cho5, Su-Young Kim6, Hyobang Moon7, Kyungho Choi1, Jeongim Park8 and Sungkyoon Kim1* 1 Seoul National University, Korea, 2 Soonchunhyang University Hospital, Korea, 3 Hallym University Medical Center, Korea, 4 Korea University Ansan Hospital, Korea, 5 Korea University Guro Hospital, Korea, 6 Jeju National University, Korea, 7 Hanyang University, Korea, 8 Soonchunhyang University, Korea P2-054 Uterotrophic and Eershberger Assays for Endocrine Disruption Properties of Plastic Food Contact Materials, Polypropylene and Polyethylene Terephthalate Bu Young Chung1, Min Ji Kyung1, Sung Kwang Lim1, Seul Min Choi1, Duck Soo Lim1, Seung Jun Kwack2, Hyung Sik Kim1 and Byung Mu Lee1* 1 Sungkyunkwan University, Korea, 2 Changwon National University, Korea P2-055 Comparison of Cytotoxicity and Sperm Motility using Computer-aided Sperm Analysis System : Phthalic Acid and Phthalic Acid Isomers, the Common Final Metabolite of Phthalates Duck Soo Lim and Byung-Mu Lee Sungkyunkwan University, Korea

P2-056 ~ 060 : Environmental Mutagens P2-056 Low-Dose Arsenic Exposure Diminished Osteoblast Differentiation from Bone Marrow Cells in Vitro and in Vivo Cheng-Tien Wu1, Kou-Tong Huang2, Tung-Ying Lu2, Rong-Sen Yang3* and Shing-Hwa Liu2* 1 The Toxicology Society of Taiwan, Taiwan, 2 National Taiwan University, Taiwan, 3 National Taiwan University Hospital, Taiwan P2-057 Genomic Plasticity in PCB126-Exposed Human Skin Keratinocytes: An Emerging Potential Mechanism of Carcinogenesis Senthilkumar P Kuppusamy, Larry Robertson and Gabriele Ludewig The University of Iowa, USA P2-058 The Impact of Environmental Pollution on Health, How to Deal with? M. I Kaadan University of Aleppo, Syria P2-059 A co-culture Cellular Model for Studying Bystander Effect and Its Application on the Investigation of Bystander Effective DNA Double-strand Breaks Induced by Alpha-particles Irradiation Chan Fan1, Yu Wang2, Xiaodan Liu2, Bo Huang1, Qin-Zhi Xu2 and Ping-Kun Zhou2* 1 The University of South China, China, 2 Beijing Institute of Radiation Medicine, China P2-060 Rudiments of Water Peter Antwi St.Thomas Institute Of Professional Studies, Gambia

P2-061 ~ 086 : Epidermiology and Exposure Assessment P2-061 Lead and Cadmium Co-exposure on Bone Mineral Density in a Chinese Population Xiao Chen1, Keyue Wang2, Caohui Gan1, Ping He1, Yihuai Liang1, Guoying Zhu1 and Taiyi Jin1 1 Fudan University, China, 2 Zuiyi Mdical College, China P2-062 Investigation of Concentration Distribution and Health Risks of Aldehydes from Cooking Oil Fumes Chiung-Yu Peng and Yi-Chun Kuo Kaohsiung Medical University, Taiwan P2-063 Health Care Workers' Skin Problems Caused by Alcohol Based Disinfectants and Antiseptics Sigrid Kalle and Viive Pille Tallinn University of Technology, Estonia The XIII 76 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-064 Pro-Infl ammatory Response in Schoolchildren Environmentally Exposed to Variety of Pollutant in the Metropolitan Area of Mexico City Leticia Rafael-Vazquez1, Marco A Sanchez-Guerra1, Leticia Hernandez-Cadena2*, Andrea De Vizcaya-Ruiz1*, Marisela Uribe- Ramirez1, Violeta Mugica3 and Betzabet Quintanilla-Vega1* 1 Toxicology Department, Cinvestav, Mexico, 2 National Institute of Public Health, Mexico, 3 UAM- Azcapotzalco, Mexico P2-065 Infl uence of City Household Waste on Ecology Environments Shodi Kholikulov1*, Tulkin Ortikov2* and Sindor Pardaev1 1 Samarkand State University, Uzbekistan, 2 Samarkand Agricultural Institute, Uzbekistan P2-066 Identifi cation and Determination of Alkaloids Pyrrolizidine: Crotaline, Heliotrine and Retrorsine by Infrared Spectroscopy Method in Biological Equine and Environmental Samples in Easter Island Laura Borgel1*, Jorge Lohse2, Dominique Sunko2, Teresa Ayerdi2 and Lucia Valenzuela2 1 RITA-Chile, Chile, 2 Universidad Mayor, Chile P2-067 Impact of Cd and Pb Impregnation on the Health of an Adult Population Neighbouring a Landfi ll Mathilde Cabral1*, Anthony Verdin1, Denis Dieme1, Saad Bouhsina1, Mamadou Fall2, Dorothee Dewaele1, Anta Tall Dia2, Amadou Diouf2 and Pirouz Shirali1 1 Universite du Littoral Cote d'Opale, France, 2 Universite Cheikh Anta Diop, Senegal P2-068 Child Poisoning in the Tadla-Azilal Region: Experience of the Moroccan Poison Control Center Safaa El Khaddam1*, Abderazak Khadmaoui1, Hinde Hami1, Fatine Hadrya1, Sanaa Achour2, Lahcen Ouammi3, Abdelmajid Soulaymani1 and Rachida Soulaymani Beincheikh3 1 Ibn Tofail University, Morocco, 2 HASSAN II and Faculty of Medicine and Pharmacy of Fes, Morocco, 3 Moroccan Poison Control Center, Morocco P2-069 Human Blood Mercury Level from Several National Surveys in Korea Daeseon Kim, Seung-Cul Ahn2, Jung-Mn Ryu*, Kyunghee Choi and Seung Do Yu National Institute of Environmenmtal Research, Korea

P2-070 Adverse Health Risk and Hematological Alterations among Farm Workers Occupationally Exposed to Mixture of Pesticides in North India Mohd. Fareed*, Manoj K Pathak, Chandrasekharan N Kesavachandran, Vipin Bihari, Ritul Kamal and Anup K Srivastava CSIR- Indian Institute of Toxicology Research, India P2-071 Metabolites Poﬁ ling associated with Urinary Heavy Metals Levels and Kidney Damages in Korean Population Eui Kyung Lee1, Siwon Kim1, Yu Jin Shin1, A Jin Won1, Eun Young Park1, Tae Hyung Kim1, Shukmann Kim1, Dahee Lee2 and Hyung Sik Kim2* 1 Pusan National University, Korea, 2 Sungkyunkwan University, Korea P2-072 Assessment of Dietary Exposure to Phthalates in Korean Adults Sung-Ok Kwon1, Hyojung Hwang1, Kyung-Su Park2 and Se-Young Oh1* 1 Kyung Hee University, Korea, 2 Korea Institute of Science and Technology, Korea P2-073 Assessment of Nanoparticle Exposure in Nanosilica Handling Process: Characteristics of Nanoparticles Leaking from a Vacuum Cleaner Boowook Kim* Occupational Lung Diseases Institute, Korea P2-074 Household Antimicrobial Product Exposure and Allergic Diseases in Korean Children Soyoung Hong1, Won-Jun Choi2, Wan Ryung Lim1, Hojang Kwon3*, Hyun Jung Kim1, Chaebong Kim1, Jeonghoon Kim1 and Hea Suk Yang1 1 Seoul Medical Center, Korea, 2 Gachon University Gil Medical Center, Korea, 3 Dankook University College of Medicine, Korea P2-075 House Dust Mite Concentration and Effect of an Educational Newsletter for Bedding Control in Child Care Center in Korea Jeonghoon Kim1, Kyoungyong Jeong2, Hojang Kwon3*, Heasuk Yang1, Hyeyung Yum1, Seonah Lee1, Chaebong Kim1, Hyunjung Kim1, Wanryung Lim1 and Soyoung Hong1 1 Seoul Medical Center, Korea, 2 Yonsei University, Korea, 3 Dankook University College of Medicine, Korea The XIII International Congress POSTER / JULY 2 (TUE) 77 of Toxicology

P2-076 The Profi le of Mixed Exposure of Koean Economic Active Population to Physical Chemical and Ergonomic Hazards Kyung Yong Rhee* Occupational Safety and Health Research Institute, Korea P2-077 Effect of Dietary Patterns on the Concentration of Serum C-reactive Protein Using KARE Study Yunhee Lee1, Daehee Kang1* and Sang-Ah Lee2* 1 Seoul National University, Korea, 2 Kangwon National University School of Medicine, Korea P2-078 A Follow-up Study of Some Hematological Parameters 4 Years After the Hebei Spirit Oil Spill Gwi Heum Eom1, Su Ryeon Noh1, Jung Ah Kim1, Hyun Sook Bae1, Seon Young Ka1, Young-Hyun Choi1, Mina Ha2* and Hae-Kwan Cheong3* 1 Taean Environmental Health Center, Korea, 2 Dankook University College of Medicine, Korea, 3 Sungkyuonkwan University School of Medicine, Korea P2-079 Soil Contamination of Sewage Sludge and Toxicological Self-Purifi cation Sindor Pardaev1* and Raim Ahmedjanov2 1 Samarkand Agricultural Institute, Uzbekistan, 2 'Samwaterconstructionindustry' Production Corporation, Uzbekistan P2-080 The Diagnostic Radiologic Technologists’ Health Study in South Korea: Study Design and Baseline Characteristics Won Jin Lee1*, Mina Ha2, Seung-Sik Hwang3, Kyoung-Mu Lee4, Young-Woo Jin5, Meeseon Jeong6, Eun Shil Cha1, Yousun Ko1, Kyung-Hwa Choi2 and Jung-Eun Lee7 1 Korea University, Korea, 2 Dankook University, Korea, 3 Inha University, Korea, 4 Korea National Open University, Korea, 5 Korea Institute of Radiological & Medical Sciences, Korea, 6 Korea Hydro & Nuclear Power Co., Korea, 7 Ministry of Food and Drug Safety, Korea P2-081 Temporal Changes in Urinary Cadmium Levels According to the Medication for Osteoporosis in Individuals with Elevated Blood or Urine Cadmium Levels Dong-Hyuk Yim1, Sang-Yong Eom1, Sun-In Moon1, Choong-Hee Park2, Guen-Bae Kim2, Seung-Do Yu2, Byung-Sun Choi3, Yong-Dae Kim1, Jung-Duck Park3 and Heon Kim1* 1 Chungbuk National University, Korea, 2 National Institute of Environmental Research, Korea, 3 Chung-Ang University, Korea P2-082 Environmental Health Indicators in Korea - Establishment, Slection and Implementation Young Mee Lee, Soon Won Jung, Jun Young Chang, Wook Hee Choi, Kyung Hwa Park, Chul Woo Lee, Kyunghee Choi and Choong Hee Park* National Institute of Environmental Research, Korea P2-083 Relationship between Phthalate Exposure and Atopic Dermatitis in Children Won-Jun Choi1, Soyoung Hong2, Hojang Kwon3*, Wan Ryung Lim2, Hyun Jung Kim2, Chaebong Kim2, Jeonghoon Kim2 and Hae Suk Yang2 1 Gachon University Gil Medical Center, Korea, 2 Seoul Medical Center, Korea, 3 Dankook University College of Medicie, Korea P2-084 Lead and Mercury in Maternal and Umbilical Cord Blood and Their Contributing Factors Sooran Choi1, Su Young Kim2*, Hai-Joong Kim3, Sungjoo Kim1, Sungkyoon Kim4, Hyo-Bang Moon5, Kyungho Choi4, Jeongim Park6, Gyuyeon Choi6, Sunmi Kim5, Sunggyu Lee5, Jeong Jae Lee6 and Soon Sup Shim2 1 Hallym University, Korea, 2 Jeju National University, Korea, 3 Korea University, Korea, 4 Seoul National University, Korea, 5 Hanyang University, Korea, 6 Soonchunhyang University, Korea P2-085 Contamination of Heavy Metals in Mushroom (Agaricus bisporu) in Tehran Market Parisa Ziarati Azad University, Iran P2-086 Study of Correlation between Heavy Metal Concentration, Street Dust and Level of Traffi c in Major Roads of Kano Metropolis Garba Uba Jigawa State Polytechnic, Nigeria

P2-087 ~ 100 : Epigenetic Regulation P2-087 The Epigenetic Silencing of Foxa2 in Cellular Replicative and Premature Senescence Induced by Hydrogen Peroxide Wenjuan Zhang1, Weidong Ji2, Linqing Yang3 and Zhixiong Zhuang3* 1 Southern Medical University, China, 2 The First Aﬃ liated Hospital of Guangzhou Medical College, China, 3 Shenzhen Center for Disease Control and Prevention, China The XIII 78 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-088 The Regulatory Role of miRNA-183 on Biological Behaviors of Esophageal Cancer Cells by Targeting PDCD4 Yang Miao, Liu Ran and Yin Lihong* Southeast University, China P2-089 Modifi cation of Histone H3 Has an Important Role in Arsenite Induced Gene Expression Toshihide Suzuki*, Kayoko Kita and Takafumi Ochi Faculty of Pharma-Science, Teikyo University, Japan P2-090 Expression and Methylation Analysis of Cyp2e1, Gstt1 and Gstm1 in Mice with Sub-Chronic Inhalation Exposure to Benzene Hong-Tao Yan*, Chun-Hua Peng, Chong Lin, Xiu-Yuan Yu, Zheng Liu and Xin-Jun Yang Wenzhou Medical College, China P2-091 Methylation of PARP-1 Promoter Involved in the Regulation of Nano-SiO2-induced Decrease of PARP-1 mRNA Expression Gong Chunmei1 and Zhixiong Zhuang2* 1 Shenzhen Center for Chronic Disease Control, China, 2 Shenzhen Center for Disease Control and Prevention, China P2-092 Inactivation of p15INK4b in Chronic Arsenic Poisoning Patients from Guizhou, China Xue Han1, Aihua Zhang1*, Lifang Wang1, Wen Chen1 and Xiaoxin Huang2 1 Guiyang Medical University, China, 2 The 44th Hospital of PLA, China P2-093 Alteration of DNA Methylation and Gene Expression of EGR1 and SOCS3 in Cord Blood Lymphocytes and Lymphoblasts Treated with Arsenite Peeyaphan Phookphan1, Supatchaya Timtavorn2, Panida Navasumrit3 and Mathuros Ruchirawat4* 1 Chulabhorn Graduate Institue, Thailand, 2 Chulabhorn Research Institute, Thailand, 3 Chulabhorn Graduate Institute, Chulabhorn Research Institute, Thailand, 4 Chulabhorn Graduate Institute, Chulabhorn Research Institute, Thailand P2-094 The Roles and Mechanisms of MicroRNAs in Chemically Induced Lung and Gastric Carcinogenesis Qiaoyuan Yang1, Jianjun Wu1, Zhiyuan Han1, Yan Wu1, Lanlan Zhou1, Yao Zhao1, Linhua Liu1, Huihan Duan1, Yuelan Shen1, Anne R Greenlee2, Chengfeng Yang3 and Yiguo Jiang1* 1 Guangzhou Medical University, Institute for Chemical Carcinogenesis, China, 2 The Jackson Laboratory, USA, 3 Michigan State University, USA P2-095 Chemical Characterization and Epigenetic Modifi cations of Fine and Utrafi ne Airborne Particles Collected in Lebanon, on Human Bronchial Epithelial Cells BEAS-2B Mireille Borgie1, Zeina Dagher2, Frederic Ledoux1, Anthony Verdin1, Dorothee Dewaele1, Fabrice Cazier1, Helene Griege2, Pirouz Shirali1 and Dominique Courcot1* 1 Universite du Littoral Cote d'Opale, France, 2 Universite Libanaise, Liban, Lebanon P2-096 Epigenetic Changes and Transgenerational Effects in Response to Hypoxia: Marine Medaka as a Model Yuan Wang, Karen Y.t. Lau, Anna Tse, S.t. Wong and Rudolf. S.s. Wu* The University of Hong Kong, Hong Kong P2-097 The Effect of Age on LINE-1 Hypomethylation in Human Peripheral Blood Lymphocytes Sonja R Christensen The University of Montana, USA P2-098 Epigenetic Effects of Chlorella Supplement on Exposure to Polycyclic Aromatic Hydrocarbons So Youn Park and Mihi Yang* 1 Sookmyoung Women’s University, Korea P2-099 Database of Transcriptional Start Sites and Epigenetic Markers for Analyzing Transcriptional Consequences of SNVs Yutaka Suzuki* University of Tokyo, Japan P2-100 Epigenetic Effect of Trichloroethylene on Human Lymphocyte and the Related Biomarker Yang Xueqin1, Zhuang Zhixiong2*, Huang Xianqing1, Liu Jianjun2, Yang Linqing2, Huang Haiyan2, Hui Changye1 and Zhang Wen1 1 Shenzhen Prevention and Treatment Center for Occupational Diseases, China, 2 Shenzhen Center for Disease Control and Prevention, China The XIII International Congress POSTER / JULY 2 (TUE) 79 of Toxicology

P2-101 ~ 153 : Food Safety P2-101 Risk Assessment and Determination of Melamine in Powder and Liquid Milks in Market of Iran Omid Sabzevari1, Shokoufeh Hassani1, Fatemeh Tavakoli1, Mohsen Amini1 and Farzad Kobarfard2 1 Tehran University of Medical Sciences, Iran, 2 Shaheed Beheshti University of Medical Sciences, Iran P2-102 Determination of Multi-Mycotoxin Occurrence in Cereals, Nuts and their Products in Cameroon by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Wilfred A Abia1, Benedikt Warth2, Michael Sulyok2, Rudolf Krska2, Angele Tchana3, Patrick B Njobeh4, Mike F Dutton4 and Paul F Moundipa3 1 Laboratory of Pharmacology and Toxicology, Cameroon, 2 University of Natura, Austria, 3 Cameroon, 4 University of Joha, South Africa P2-103 Effect of Microwave Heating and Drying on the Bioactive Compounds of Some Leafy Vegetables Sahar M Kamel King Faisal University, Saudi Arabia P2-104 Household Risk Mitigation Methods For Pesticide Residues in Tomato For Food Safety Cherukuri S Rao, Vemuri S Bhushan, Harinatha A Reddy and Ravindra D Nath Acharya N G Ranga Agricultural University, India P2-105 Washing the Foodstuffs of Seeds, Promoting the Health Level, a Proposal for Legislation of National Standard of Food Safety Xu Han-You Clinical Institute, China P2-106 Use of Synchrotron X-Ray to Study Chemical Forms and Oxidation State of Metal Elements in Mineral Supplements for Livestock Peiqiang Yu University of Saskatchewan, Canada P2-107 Cordyceps Mushroom Poisoning: Case-Series Report Vy U Doan1 and Trung C Doan2 1 Cho Ray Hospital, Viet Nam, 2 University of Pharmacy and Medicine of Ho Chi Minh City, Viet Nam P2-108 Simultaneous Determination of Lead and Cadmium in Baby Weaning Food by DPASV Mohammad Reza Oveisi1, Naﬁ ceh Sadeghi1, Behrooz Jannat2, Mannan Hajimahmoodi1, Abdolazim Behfar3, Masoomeh Behzad1, Forouzandeh Jannat1 and Narges Norouzi1 1 Tehran University of Medical Sciences, Iran, 2 Food and Drug Organization, Ministry of Helth, Iran, 3 Ahvaz Jundishapur University, Iran P2-109 Repeated Dose 28-Day Oral Toxicity Study of Fusarium Mycotoxin Moniliformin Martina Jonsson1, Marika Jestoi1, Janne Atosuo2, Alexis Nathanail1, Pertti Koivisto1, Ulla-Maija Kokkonen1, Marjukka Anttila1, Esa-Matti Lilius2 and Kimmo Peltonen1* 1 Finnish Food Safety Authority, Finland, 2 University of Turku, Finland P2-110 Food Contaminants: Analytical Expertise in Toxicology and Reglementation Aspects Sedjelmaci Nesrine CHU Tlemcen, Algeria P2-111 Effects of Prunella Vulgaris on the Mice Immune Function Min Zhao, Rui Huang, Fen X Yang*, Ming J Huang and Feng B Chen Guangdong Provincial Centre for Disease Control and Prevention, China P2-112 Lack of Evidence for Genetic and Developmental Toxicity of Prunella vulgaris Bifeng Chen, Min Zhao, Ying Yang, Junming Huang and Xingfen Yang* Guangdong Provincial Centre for Disease Control and Prevention, China P2-113 Subchronic Toxicity of Biﬁ dobacterium Animals V9 in Rats Li Yongning China National Center for Food Safety Risk Assessment, China The XIII 80 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-114 Safety Evaluation of Nanomaterials in Food Based on Gut Flora Takahide Mori1, Yasuo Yoshioka1, Tokuyuki Yoshida1, Miyuki Uji1, Kazuki Misato1, Asako Udaka1, Shin-Ichi Tsunoda2, Hiromi Nabeshi3, Tomoaki Yoshikawa1, Kazuma Higashisaka1 and Yasuo Tsutsumi1* 1 Osaka University, Japan, 2 National Institute of Biomedical Innovation, Japan, 3 National Institute of Health Science, Japan P2-115 Safety Assessment of Dicamba Monooxygenase from the Biotechnology-Derived Soybean MON 87708 Mia Park1, Shawna Lemke2, Michael Koch2, Luis Burzio2, John Finnessey2, Terry Kaempfe2, Heidi Kang2, Andre Silvanovich2, Cunxi Wang2 and Erin Bell2 1 Monsanto Korea, Ltd., Korea, 2 Monsanto Company, USA P2-116 Assessing the Safety of GM Crops: the Appropriate Role of Animal Toxicology Studies for Proteins and Whole Foods Shawna Lemke1 and Task Force 10 Members2 1 Monsanto Company, USA, 2 ILSI IFBiC, USA P2-117 Rapid Detection and Determination of Aﬂ atoxins in Ground Corn by Raman Spectroscopy Kyung-Min Lee1, Timothy J Herrman1 and Unil Yun2 1 Texas A&M University, USA, 2 Chungbuk National University, Korea P2-118 Feasibility of Raman Spectroscopy for Rapid Screening Fumonisin Contaminated Corn Samples Kyung-Min Lee1, Timothy J Herrman1, Christian Nansen2 and Unil Yun3 1 Texas A&M University, USA, 2 The University of Western Australia, Australia, 3 Chungbuk National University, Korea P2-119 Harnessing the Uniqueness of Bacillus sp.: an Integrative Approach for Hydrogen and PHB Production by Single Bacterial Strain Prasun Kumar1, Mamtesh Singh2, Sanjay K Patel2 and Vipin C Kalia1* 1 CSIR-IGIB, India, 2 IGIB, India P2-120 Trends of Food Poisonings Caused by Poisonous Plants in Japan, 1989-2010 Miou Toda*, Chikako Uneyama and Fumiko Kasuga National Institute of Health Sciences, Japan P2-121 Co-exposure of Fusarium Mycotoxins: in vitro Myelotoxicity and Immunotoxicity Assessment on Human Anne-Sophie Ficheux, Yann Sibiril and Dominique Paren-Massin Laboratoire d’Evaluation du Risque Chimique pour le Consommateur. Universite de Bretagne Occidentale, France P2-122 An On-line Solid-Phase Extraction Liquid Chromatography Tandem Mass Spectrometry LC-MS/MS Method for Analysis of Ractopamine in Serum and Urine Samples Ming-huan Lin1 and Kuen-Yuh Wu2* 1 National Health Research Institutes, Taiwan, 2 National Taiwan University, Taiwan P2-123 Determination of Heavy Metal Levels in Raw Cow's Milks Collected From Dairy Farms in Bayburt Ayla Arslaner, Latife B Alkan*, Huseyin Serencam and Emin Mercan Bayburt University, Turkey P2-124 Phthalate Migration From Food Package and Other Food Contact Plastics Ayla Arslaner, Kubra Aksehir* and Latife B Alkan Bayburt University, Turkey P2-125 Levels of Organochlorine Pesticides Residues in Cowpea Grains and Dried Yam Chips in Ile-Ife, Nigeria Mosudi B Sosan, Yusuf A Olufade and John A Oyekunle Obafemi Awolowo University, Nigeria P2-126 Extracts from Two Aromatic Plants from Algeria as Substitutes of Synthetic Antioxidant Agents Fouad Menaceur* and Hazzit Mohamed Ecole Nationale Superieure Agronomique, Algeria, P2-127 Histamine Content and Histamine-forming Bacteria in Mahi-mahi (Coryphaena hippurus) Fillets and Dried Products Tsai Yung Hsiang1, Lee Yi Chen2, Lin Chung Sanit3, Huang Tzou Chi2, Kung Hsien Feng4, Li Pei Xia1, Huang Yu Ju5, Tseng Pei Hui1 and Yu Cai Rou1 1 National Kaohsiung Marine University, Taiwan, 2 National Pingtung University of Science and Technology, Taiwan, 3 Yuanpei University, Taiwan, 4 Tajen University, Taiwan, 5 National Penghu University of Science and Technology, Taiwan The XIII International Congress POSTER / JULY 2 (TUE) 81 of Toxicology

P2-128 Determination and Frying Loss of Histamine in Striped Marlin Fillets Implicated in a Food-borne Poisoning Tsai Y Hsiang1, Lee Y Chen2, Lin C Saint3, Huang T Chi2, Kung H Feng4, Li P Xia1, Huang Y Ru5, Tseng P Hui1 and Yu C Rou1 1 National Kaohsiung Marine University, Taiwan, 2 National Pingtung University of Science and Technology, Taiwan, 3 Yuanpei University, Taiwan, 4 Tajen University, Taiwan, 5 National Penghu University of Science and Technology, Taiwan P2-129 Systematic Study of Mycotoxin in Feeds is Important for Crop, Feed, Processing, Livestock and Export Industries: A Review S. Abeysekara and Peiqiang Yu* University of Saskatchewan, Canada P2-130 No Signiﬁ cant Adverse Effect of Nanoclay Primarily Consisting of Montmorillonite in a Rat 13-week Dietary Administration Study Kumiko Ogawa1*, Saeko Onami1, Young-Man Cho1, Takeshi Toyoda1, Jun-Ichi Akagi1, Isamu Suzuki1, Yasuko Mizuta1 and Akiyoshi Nishikawa2 1 Pathology, National Institute of Health Sciences, Japan, 2 Biological Safety Research Center, National Institute of Health Sciences, Japan P2-131 In Vitro Mutagenicity and Genotoxicity of Stabilized Rice Bran Oil Extract Iman Emam Omar Gomaa German University, Egypt P2-132 The Food Safety Situation of Mongolia: Current and Future Trends Namnansal Ragchaasuren Academy Management Government Agency of Mongolia, Mongolla P2-133 Procoagulant and Prothrombotic Effects of Herbal Medicine, Dipsacus Asper and its Active Ingredient, Dipsacus Saponin C, on Human Platelets Ji-Seon Song1, Kyung-Min Lim2, Seojin Kang1, Ji-Yoon Noh1, Keunyoung Kim1, Ok-Nam Bae3 and Jin-Ho Chung1* 1 Seoul National University, Korea, 2 Ehwa Womans University, Korea, 3 Hanyang University, Korea P2-134 Factors Inﬂ uencing Internal Exposure to Phthalate and BPA Ji Ae Lim1, Ho-Jang Kwon1*, Se-Yung Oh2, Jung-Dck Park3 and Heesoo Pyo4 1 Dankook University College of Medicine, Korea, 2 Kyung Hee University, Korea, 3 Chung-Ang University, Seoul, Korea, 4 Korea Institute of Science and Technology, Korea P2-135 Operational Characteristics and Microbial Inactivation Performance of Corona Discharge Plasma Jet System Chulkyoon Mok1*, Taehoon Lee1 and Su-Meong Hong2 1 Gachon University, Korea, 2 National Academy of Agricultural Science, Korea P2-136 Permeability of Gucosinolate Dgradation Poducts Aross Caco-2 monolayer Youngsun Lee and Hoonjeong Kwon* Seoul National University, Korea P2-137 In Vitro Metabolic Conversion of Organic Degradation Products of Glucosinolate to Thiocyanate anion Juyoung Lee and Hoonjeong Kwon* Seoul National University, Korea P2-138 Analysis of Lead, Cadmium, Mercury and Di-(2-EthylHexyl)-Phthalate in Food Packaging Eun-Ae Yu1, Bong-Jae Lee1, Eun-Ju Kim2, Jong-Hwan Kim1, Ju-Hye Kim1 and Jong-Su Seo1* 1 Analytical & Environmental Chemistry Center, Korea Institute of Toxicology (KIT), Korea, 2 TECO Science, Korea P2-139 Residue Analysis of Veterinary Drugs in Livestock Products by HPLC and LC/MS/MS Younjeong Han, Seongsoo Park, Hyunjin Joo, Miok Kim, Hyeshin Hwang, Jisun Lee, Moosong Lim and Daehyun Cho* Gyeongin Regional Food and Drug Administration, Korea P2-140 Norovirus Monitoring of Ground Water in Facilities for Providing Meals Donghyuk Seo, So Young Chung, Ji Eun Park, Yu Jihn Kwon, Eun Joo Koo, Kyung Chul Cho, Mee Hyun Cho, A Reum Han and Dae Hyun Cho* Gyeongin Regional Food and Drug Administration, Korea P2-141 Distribution of Hygienic Indicator Microorganisms in Dried Fishes Meehyun Cho, Eun Joo Koo, A Reum Han, Yu Jihn Kwon, Ji Eun Park, Dong Hyuk Seo, Kyung Chul Cho, So Young Chung and Dae Hyun Cho* Gyeongin Regional Food and Drug Administration, Korea The XIII 82 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-142 Monitoring Adulterated Foods with Illegally Added Drugs Hyunjin Joo1, Seong-Soo Park2, Jisun Lee2, Moo-Song Lim2, Hye Shin Hwang2, Miok Kim2, Yun-Jeong Han2 and Dae Hyun Cho2* 1 Ministry of Food and Drug Safety, Korea, 2 Gyeongin Regional Food and Drug Administration, Korea P2-143 The Evaluation of Type B Trichothecenes in Cereals - Method Development and Monitoring of Type B Trichothecenes in Cereals in Korea Seungyoung Park, Soojung Hu, Hwami Lee, Hyunsook Lee, Keunhwa Choi, Namsun Kim, Yongwoo Shin and Daehyun Cho* Gyeongin Regional Food & Drug Administration, Korea P2-144 Phenethylamine Derivatives in Commercially Available Pre-workout Supplements Jaesin Lee, Hyeyoung Choi, Sewoong Heo, Wonkyung Yang, Meejung Park and Eunmi Kim National Forensic Service, Korea P2-145 Monitoring of Lipid Oxidation Products in Deep Frying Soybean Oil From School Deep Fryer Eunmi Koh Seoul Women's University, Korea P2-146 Safety Evaluation of Formaldehyde Migrated from Melamine-ware Jaemyoung Oh, Dongwoo Shin, Jaechon Choi, Hosoo Lim, Sejong Park and Meehye Kim Ministry of Food and Drug Safety, Korea P2-147 Preparation of Yogurt Lyophilized Powder to Achievement a Complementary Tablet Abdolhossein Moghbel1*, Mehrdad Ghiasvand1, Enayat Ollah Salimi1, Masoud Karami1, Hamideh Abbaspour2 and Homaun Agheli1 1 Ahvaz Jundishapur University of Medical Sciences, Iran, 2 Shahid Beheshti University of Medical Sciences, Iran P2-148 Heavy Metal Contents in Soil, Irrigation Water, Okra, Brinjal And Estimation of Their Daily Intake Grown in Peri-Urban Farming System Punjab, Pakistan Muhammad A Randhawa* and Faqir M Anjum University of Agriculture, Pakistan P2-149 Simultaneous Occurence of Mycotoxins in Red Peppers Sebahat Ozakca Bayburt University, Turkey P2-150 Polycyclic Aromatic Hydrocarbons in Circassian Cheese Available in the Turkish Markets Muhammet Dervisoglu1, Osman Gul1*, Mustafa Mortas1, Oguz Aydemir2, Eda Ilhan3 and Kubra Aksehir4 1 Ondokuz Mayis University, Turkey, 2 Cankırı Karatekin University, Turkey, 3 Hitit University, Turkey, 4 Bayburt University, Turkey P2-151 Aqueous Garlic Extract and Rabbit Experimental Modelling; Safety Health Concerns Haﬁ z Ansar R Suleria1*, Masood S Butt1, Faqir M Anjum1 and Nauman Khalid2 1 University of Agriculture, Pakistan, 2 University of Tokyo, Japan P2-152 Macrophage Inhibitory Cytokine 1 Prolongs Pro-inﬂ ammatory NF-kB activation by Mocosa-associated Bacterial Exposome Hye Jin Choi1, Dongwook Kim2, Beob Gyun Kim3 and Yuseok Moon1* 1 Pusan National University School of Medicine, Korea, 2 National Institute of Animal Science, RDA, Korea, 3 Konkuk University, Korea P2-153 Histamine Content in Fish and Fish Products (Salted, Smoked and Frozen Fish ) with Relation to Microbial Load Mohamed M Deabes1, Sayed A Ahmed2, Hayam A Mansour2, Laila A Mohamed1 and Doha A Salah El Din1 1 National Research Centre, Egypt, 2 Cairo University, Egypt

P2-154 ~ 164 : Genetic Polymorphisms P2-154 Ameliorative Effect of Picrorhiza Kurroa during Experimentally Induced Aﬂ atoxicosis in Broilers Vasudha B Musale, G. B Kulkarni, G. R Gangne, S. U Kapse and S. L Dake Maharashtra Animal and Fishery Sciences University Nagpur, India P2-155 Synthesis And Evaluation of Lamotrigine- Glutathione Inducing Amino Acid Conjugate To Minimize Hepatotoxicity: A Prodrug Approach Anupam G Banerjee, Saurabh K Sinha, Sushant K Shrivastava and Radhey S Srivastava Banaras Hindu University, India The XIII International Congress POSTER / JULY 2 (TUE) 83 of Toxicology

P2-156 Prevalence Of 5-HT2A Serotonin Receptor Gene Polymorphism In Smoking Behavior Among Malay Population Nur I A. Rozak, Imran Ahmad, Harmy Mohd Yusuff and Ruzilawati Abu Bakar Universiti Sains Malaysia, Malaysia P2-157 Paraoxonase Aactivity and Genetic Polymorphisms in North Han Chinese workers Exposed to Organophosphate Pesticides Xiaofeng Zhang1, Hong Sui1, Jing Zheng2, Fengqian Wang1 and Baixiang Li1* 1 School of Public Health, Harbin Medical University, China, 2 Heilongjiang Provincial Center of Disease Prevent and Control, China P2-158 Urinary Bladder Cancer Risk, Polymorphic Enzymes and Structural Change in the Local Coal, Iron and Steel Industry Daniel Ovsiannikov1, Silvia Selinski2, Marie-Louise Lehmann2, Meinolf Blaszkewicz2, Oliver Moormann1, Matthias W Haenel3, Hermann M Bolt2, Jan G Hengstler2 and Klaus Golka2 1 Department of Urology, St.-Josefs-Hospital Dortmund-Horde, Germany, 2 Leibniz Research Centre for Working Environment and Human Factors (IfADo), Germany, 3 Max-Planck-Institut fur Kohlenforschung, Mulheim an der Ruhr, Germany P2-159 Inﬂ uence of Genetic Polymorphism of Oxidative Stress Genes on DNA Damage in Mobile Tower's Radiation Exposed Human Population. Sachin Gulati, Anita Yadav*, Shiv K Giri, Neeraj Kumar, Kanu Priya, Gaurav Kumar, Sanjeev K Gautam and Ranjan Gupta Department of Biochemistry, Kurukshetra University, India P2-160 Genetic-based Reference Values for Butyrylcholinesterase Enzyme (BChE) in a Colombian Population Oscar Florez Vargas, Olga M Medina Perez, Linda P Rocha Munoz, Guillermo Gomez Moya, Clara I Gonzalez Rugeles and Luz H Sanchez Rodriguez* Universidad Industrial de Santander, Colombia P2-161 Genetic Variation in IL-1β Gene May Affect IL-1β Levels and Pain Control in Cancer Patients Ana Oliveira1*, Ricardo J Dinis-Oliveira1, Augusto Nogueira2, Ferraz Goncalves2, Paula Silva2, Felix Carvalho1 and Rui Medeiros2 1 University of Porto, Portugal, 2 IPO-Porto, Portugal P2-162 Identiﬁ cation of Quantitative Trait Loci (QTL) Associated with Inorganic Arsenic Metabolism using Recombinant Inbred Strains of Mice Tetsuro Agusa1, Hiroaki Komori2, Yoshiko Soga2, Masato Nose2, Shiro Mori3, Reiji Kubota4, Shinsuke Tanabe1 and Hisato Iwata1 1 Center for Marine Environmental Studies (CMES), Ehime University, Japan, 2 Ehime University Graduate School of Medicine, Japan, 3 Tohoku University Graduate School of Dentistry, Japan, 4 National Institute of Health Sciences, Japan P2-163 Would DRD2 and SERT Gene Polymorphisms be a Common Genetic Cause for Drug Abuse Vulnerability and Cardiac Disorders? Yasmeen M Taalab1*, Imke Puls2, Andreas Heinz2, Abdel-Aziz A Ghanem1, Seham A Gad Elhak1, Mohammad S Al-Haggar1 and Doaa A El Morsi1 1 Mansoura University, Egypt, 2 Charite University, Germany P2-164 Relationship Gene Polymorphisms of Insulin Receptor Substrate 1 (IRS1) and β3-adrenergic Receptor (β3-AR) with Cardiovascular Risk Factors in Workers Exposed to Hazardous chemical Ki W Kim, Yong L Won and Kyung S Ko Occupational Safety and Health Research Institute, Korea

P2-165 ~ 189 : Genotoxicity P2-165 Evaluation of Radioprotective Effect of Turkish Propolis Exracts on γ-ray-induced Human Fibroblast Cell Lines Can O Yalcin1*, Yuksel Aliyazıcıoglu2, Selim Demir2, Orhan Deger2, Ibrahim Turan3 and Zumrut Bahat4 1 Ankara University, Turkey, 2 Karadeniz Technical University, Turkey, 3 Gumushane University, Turkey, 4 Karadeniz Technical University, Turkey P2-166 Genotoxic Potential of Organic Extracts from Particle Emissions of Diesel and Rapeseed Oil Powered Engines Jan Topinka1, Alena Milcova1, Jana Schmuczerova1, Martin Mazac2, Martin Pechout2 and Michal Vojtisek-lom2 1 Institute of Experimental Medicine AS CR, Czech, 2 Faculty of Mechanical Engineering, Technical University of Liberec, Czech The XIII 84 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-167 Effect of Amalgam Fillings on Gene Expression Profi les in Rat Blood Yoshifumi Takahashi1, Shozo Tsuruta1, Akiko Honda2, Yasuyuki Fujiwara1, Masahiko Satoh1 and Akira Yasutake3 1 Aichi Gakuin University, Japan, 2 Kyoto University, Japan, 3 Kumamoto University, Japan P2-168 Acetoxylated Monoglyceride, an Alternative Plasticizer to Phthalate does not Induce DNA Damage by in Vivo Comet Assay in Rats Alicja Mortensen1*, Annop K Sharma1, Anette Schnipper1 and Lars Wiebe2 1 DTU Food / National Food Institute, Denmark, 2 Dupont, Denmark P2-169 Micronucleus Induction after Exposure of Mixture of Acetamiprid and Propineb Pesticides on Human Peripheral Blood Lymphocyte Culture Fulya D Gokalp Muranlı1*, Pınar Goc Rasgele2, Meral Kekecoglu2, Kezban Ozdemir1 and Martin Kanev1 1 Trakya University, Turkey, 2 Duzce University, Turkey P2-170 Genotoxicity Analysis of Kefi r Fang Chun Sun*, Chao Tong Li and Hsiao Ling Chen Department of Bioresources, Da-Yeh University, Taiwan P2-171 The Protective Role of Palm Oil Tocotrienol Rich Fraction in Reducing the Toxicity Effects Induced by Fenitrothion in Sperm Rats Izatus Shima Taib, Siti Balkis Budin*, Ahmad Rohi Ghazali, Putri Ayu Jayusman and Jamaludin Mohamed Universiti Kebangsaan Malaysia, Malaysia P2-172 Hibiscus Sabdariffa UKMR-2: a Novel Source in Reducing Spermatoxicity in Streptozotocin Induced Diabetes Rats Muhd Hanis B Md Idris1*, Siti Balkis B Budin1, Mohamad B Osman2 and Jamaludin B Mohamed1* 1 Universiti Kebangsaan Malaysia, Malaysia, 2 Universiti Teknologi MARA, Malaysia P2-173 Investigation of Germ Cell Genotoxicity by Using the in Vivo Comet Assay in Testis Cells of Mice Anoop K Sharma*, Alicja Mortensen, Eva B Wedebye, Marianne Dybdahl, Merete K Hansen and Murat Kulahci Technical University of Denmark, Denmark P2-174 Effects of DEP Treatment on Oxidative DNA Damage and Infl ammatory Responses in Human Epithelial and Lymphoblast Cells Jantamas Kanitwithayanun, Udomratana Vattanasit, Man Barhadur Khadka, Potchanee Hunsonti, Varaporn Parnlob, Panida Navasumrit and Mathuros Ruchirawat* Chulabhorn Research Institute, Thailand P2-175 Investigation of Prochloraz Induced DNA Damage Ezgi Oztas, Mahmoud Abudayyak, Gul Ozhan and Buket Alpertunga* Istanbul University, Turkey P2-176 Evaluation of Genotoxic/Antigenotoxic Potential of Vanillic Acid by Cytokinesis Blocked Micronucleus Assay Gokce Taner1, Deniz Ozkan Vardar2, Zeki Aytac1, Arif A Basaran3 and Nursen Basaran3* 1 Gazi University, Turkey, 2 Hitit University, Turkey, 3 Hacettepe University, Turkey P2-177 Abatement by the Flavonoid Wogonin of Etoposide-induced Genomic Damage in Mice Sabry M Attia* and Saleh Bakheet King Saud University, Saudi Arabia P2-178 Chromosome Aberrations and Urinary Thioethers in Smokers Nkwame Melvis Njenge1*, Abue S Alloysious1, Ekeme Richard Mbidikim2, Mbella Noela Tchenko3 and Salle Princewill1 1 Institute of Biomedical Research Buea, Cameroon, 2 University of Buea, Cameroon, 3 Regional Hospital Buea, Cameroon P2-179 Protective Effects of Ferulic Acid on the Sepsis-Induced DNA Damage in the Liver Cells of Rats Merve Bacanlı1, Sevtap Aydın1, Gokce Taner2, Tolga Sahin1, A. Ahmet Basaran1 and Nursen Basaran1* 1 Hacettepe University,Turkey, 2 Gazi University,Turkey P2-180 The Effects of Resveratrol on Sepsis-Induced DNA Damage Sevtap Aydın1, Merve Bacanlı1, Gokce Taner2, Tolga Sahin1, Ahmet Basaran1 and Nursen Basaran1* 1 Hacettepe University, Turkey, 2 Gazi University, Turkey The XIII International Congress POSTER / JULY 2 (TUE) 85 of Toxicology

P2-181 Evaluation of Solvents for Genotoxicity in in Vitro Study; Results of a Comparative Study on the Pre- incubation Method and Plate Incorporation Method Using Solvents Yun-Jung Kim1, Mi-Young Lee1, Sun-Kyoung Kim1, Hye-Young Nam1, Cho-Rong Park1, E-Na Lee1, Ji-Hye Han1, Sang-Koo Lee1 and Jong-Koo Kang2* 1 Biotoxtech Co., Ltd., Korea, 2 Chungbuk National University, Korea P2-182 Validation of the in Vivo Rodent Alkaline Comet Assay Using the Six Vehicles and Two Alkylating Agents Ji-Young Kim, Seng-Min Back, Jung Kwon and Ji-Yeon Kim Korea Institute of Toxicology, Korea P2-183 Establishment of Flow Cytometry based High-throughput Genotoxicity Testing Using Peripheral Blood Joohwan Kim, Young Na Yum, Dae-Hyoun Lim, Chea Hyung Lim, Jun Young Yang, Yong Kyoung Lee, Il Young Ahn and Ki Hwan Choi* Korea Food and Drug Administration, Korea P2-184 Parkinson’s Disease-associated LRRK2 Mutation Causes Abnormal Protein Accumulation by Impairing Cytoskeleton Reorganization Yeojin Bang and Hyunjin Choi* CHA University, Korea P2-185 The Chromosome Aberration Test of Neem Oil in Chinese Hamster Lung Cells Hyeon Jo Cho, Hyun-Joo Yoon, Je-Bong Lee, Mi-Hye Jeong, Doo-Ho Kim and Min-Kyoung Paik* National Academy of Agricultural Science, Rural Development Administration, Korea P2-186 Bacterial Reverse Mutation Test of Sophora Radix Extract using Salmonella Typhimurium Hyunjoo Yoon, Hyeon-Jo Cho, Je-Bong Lee, Jin-A Oh, Doo-Ho Kim and Min-Kyoung Paik* National Academy of Agricultural Science, Rural Development Administration, Korea P2-187 Mechanisms of Genotoxic Potential of DNA Topoisomerases Inhibitors and the Possible Chemoprotective Activity of Natural Products Sabry M Attia* King Saud University, Saudi Arabia P2-188 Genotoxic Effects of Metronidazole in Patients at the Limbe Mile One Hospital George Njume*, Ewang E Fidelis, Ndode Celestine Njume and Mbah F David Institute of Medical Research Science, Cameroon P2-189 Low Dose of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) Induce Cellular Senescence via Promoting ROS and DNA Damage in PC12 Cells Jiao Liu, Chunhua Wan, Xiaoke Nie, Jianya Zhao, Gang Chen, Cuiying Tang, Lingwei Liang and Guangfei Xu* Nantong University, China

P2-190 ~ 216 : Hepatotoxicity P2-190 Evaluation of the Potential Toxicity of Dibromoacetonitrile-Induced Apoptosis and Tumor -Initiating Activity in Rat Liver Neveen Salem National Research Centre, Egypt P2-191 Scenario of Mushroom Poisoning in a Tertiary Care Hospital Prahlad Karki, V A Syed, R Lakshmi, B Pradhan and R Maskey B. P. Koirala Institute of Health Sciences, Nepal P2-192 Nrf2 Enhances a Hepatotoxin-induced hepatic Cell Expansion Keiko Taguchi, Hozumi Motohashi and Masayuki Yamamoto* Tohoku University, Japan P2-193 The Protective Effect of Livergol Against Liver Toxicity Induced by Bromobenzene in Mice Heibatullah Kalantari, Iran Rashisi, Zahra Nazari Khorasgani and Atefeh Keliddar Ahvaz Jundishapur University of Medical Sciences, Iran The XIII 86 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-194 Protective Effects of Selenium on Aspirin and Diazinon-induced Hepatotoxicity in the Rat Abdel-tawab H Mossa National Research Centre, Egypt P2-195 Time-Course Analysis of Trichloroethylene Metabolism and its Association with Subchronic Toxicity in Liver Hong Sik Yoo, Leonard B Collins, Tetyana Kobets, Oksana Kosyk, Blair U Bradford, Svitlana Shymonyak, Wanda M Bodnar, Louise M Ball, Avram Gold and Ivan Rusyn* University of North Carolina at Chapel hill, USA P2-196 DADS Suppressed Ethanol-Induced Liver Injury by Activating HO-1 System in Mice Tao Zeng and Keqin Xie* Institute of Toxicology, Shandong University, China P2-197 The Protective Role of Palm Oil Tocotrienol Rich Fraction on Fenitrothion-induced Oxidative Damage in Rat Liver Putri Ayu Jayusman, Siti Balkis Budin*, Ahmad Rohi Ghazali and Izatus Shima Taib Universiti Kebangsaan Malaysia, Malaysia P2-198 Sulfi te Induced Hepatocytes Death is not Associated to p53 Pathway Jianying Bai*, Peiyu Lei, Jidong Zhang, Chunyan Zhao, Zhihong Zhang and Ruifeng Liang Shanxi Medical University, China P2-199 Organic Cation Transporter 1 Mediates the Uptake of Monocrotaline and Plays a Key Role in its Hepatotoxicity Meijuan Tu, Siyuan Sun, Kai Wang, Xueying Peng, Ruihan Wang, Su Zeng, Hui Zhou* and Huidi Jiang* Zhejiang University, China P2-200 Resveratrol Does Not Protect Against Paracetamol-induced Cell Death in Mouse Primary Hepatocytes Alice E Kane1*, Aniko Huizer-Pajkos2, Victoria Cogger1, David G Le Couteur1 and Sarah N Hilmer2 1 University of Sydney, Australia, 2 Royal North Shore Hospital, Australia P2-201 Rat Hepatocytes Isolated from Fatty Liver Exert Higher Sensitivity to Oxidative Stress Zuzana Cervinkova*, Otto Kucera, Tomas Rousar3, Halka Lotkova, Miroslav Cervinka and Rene Endlicher Charles University in Prague, Czech P2-202 Regulation of Cathepsin L and B by Hepatotoxic Agents Mansi Manchanda, Ratnakar Singh and Shyam S Chauhan* All India Institute of Medical Sciences, India P2-203 Protective Effects of Saponarin from Gypsophila Trichotoma on Carbon Tetrachloride-induced Hepatotoxicity in Vitro/ in Vivo in Rats Rumyana Simeonova*, Magdalena Kondeva-Burdina, Vessela Vitcheva, Ilina Krasteva, Vassil Manov and Mitka Mitcheva University of Forestry, Bulgaria P2-204 Infl uence of Fenugreek Seed and Cinnamon Bark Extracts on Body Weight, Blood Glucose and Lipid Profi les in Diabetic Rats Nagi M Leji Sebha University, Libya P2-205 Hpatotoxicity of Cyromazine and Chlorpyrifos in Rat: the Protective Effects of Green Tea Extract Tarek M Heikal* and Abdel-Taab H Mossa National Research Centre, Egypt P2-206 Comparison of Hepatotoxic Retrorsine in 3D/2D Culture Orientation in HepG2 Cells Wai T Fung1, Mengbi Yang2, Jianqing Ruan2, Henry Leung1* and Ge Lin2* 1 Nanyang Polytechnic, Singapore, 2 The Chinese University of Hong Kong, Hong Kong P2-207 Protective Effects of Pomegranate Seed Oil against Carbon Tetrachloride-Induced Hepatotoxicity Hossein Niknahad*, Fatemeh Alipour and Azadeh Hamedi Shiraz University of Medical Sciences, Iran The XIII International Congress POSTER / JULY 2 (TUE) 87 of Toxicology

P2-208 Pesticides Mixture Effects on Hepatotoxicity of Tiazoles: Hexaconazole, Difenoconazole and Flutriafol Repeated Dose 28-day Oral Toxicity Studies in Rats Chun-Hung Yang* and Wei-Ren Tsai Taiwan Agriculture Chemicals and Toxic Substances Research Institute, Council of Agriculture, Taiwan P2-209 FXR Protects Hepatocytes from Injury by Inducing LKB1 Chan Gyu Lee Seoul National University, Korea P2-210 A Study on the Drug-Induced Hepatotoxicity Using HepG2 Cell Hye Jin Cha, Su-Mi Ahn, Joon-Ik Ahn, Seol-Hee Jeon, Hyun-Wook Kim, Ho-Sang Jeong, Eun Jung Kim, Soon Young Han and Hoil Kang* NIFDS, Korea P2-211 Expression of Epithelial Cell Adhesion Molecule and Neighbor of Punc E11 in Diethylnitrosamine Induced Hepatocarcinogenesis Young Hee Kim, Kyung A Kwak and Jin Seok Kang Namseoul University, Korea P2-212 The Amelioration of Acetaminophen Toxicity by Korean Red Ginseng Extract and Ginsenoside Rg3 via Regulation of Metabolism and Transports in Vivo and in Vitro Sang Il Gum and Min Kyung Cho* Dongguk University, Korea P2-213 LXR-α Antagonist Meso-dihydroguaiaretic Acid Attenuates High-fat Diet-induced Nonalcoholic Fatty Liver Woo-Cheol Sim1, Sora Park1, Kang-Yo Lee1, Young-Tae Je1, Hu-Quan Yin2, You-Jin Choi1, Sang Hyun Sung1, So-Jung Park3, Hyun-Ju Park3, Kye Jung Shin4 and Byung-Hoon Lee1* 1 Seoul National University, Korea, 2 University of South Florida Health Sciences Center, USA, 3 Sungkyunkwan University, Korea, 4 The Catholic University, Korea P2-214 Pin1 Induction in Fibrotic Liver and its Roles in TGF-beta1 Signaling Jin Won Yang1, Tran T Hien2 and Keon Wook Kang1* 1 Seoul National University, Korea, 2 Chosun University, Korea P2-215 Gene Expression Proﬁ ling on Liver Effects in a Multistrain Panel of Inbred Mouse Model after Trichloroethylene Exposure Youngah Ahn1, Seungho Lee1, Oksana Kosyk2, Ivan Rusyn2 and Sungkyoon Kim1* 1 Seoul National University, Korea, 2 University of North Carolina, USA P2-216 The Hepatprotective of Corn Silk against Dosage Induced by MDMA by Isolated Rat Liver Perfusion System Mohammad Karami Mazandaran University of Medical Sciences, Iran

P2-217 ~ 239 : Immunotoxicity P2-217 Trichloroethylene-Induced Allergic Disorders Were Associated with Hepatic Metabolic Enzyme Genes and Immune-related Genes Xinyun Xu*, Yuefeng Liu, Jiyan Mao and Kanlang Mao Shenzhen Center for Disease Control and Prevention, China P2-218 3 Phosphoric Acid Inositol Receptor and Ryanodine Receptor Participate in the Modulation of Calcium Homeostasis Disorder Induced by Traﬃ c-related PM2.5 in Jurkat T Cells Jie Jing Liu, Zhi Hong Zhang*, Ying Zhao, Yong Qiu and Jian Jun Xu Shanxi Medical University, China P2-219 Lymphofollicular Hyperplasia of Thymus and Intravascular Hemolysis as Result of Low Concentrations Inﬂ uence of Hexavalent Chromium Akziya N Zhumabayeva, Erbol Z Bekmukhambetov*, Natalia V Zarishnyak and Timur A Jarkenov West Kazakhstan State Medical University, Kazakhstan The XIII 88 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-220 Pivotal Role of PKCbeta in Allergen-Induced CD86 Expression Adn IL-8 Release in THP-1 Cells Emanuela Corsini*, Valentina Galbiati, Marina Marinovich and Corrado L Galli DiSFeB, Universita Degli Studi di Milano, Italy P2-221 Uptake of Food Antigen with Silica Nanoparticles Enhance Immune Response to Food Antigen Kazuki Misato1, Yasuo Yoshioka1, Tokuyuki Yoshida1, Miyuki Uji1, Asako Udaka1, Takahide Mori1, Manami Yamaguchi1, Toshiro Hirai1, Shin-Ichi Tsunoda2, Kazuma Higashisaka1 and Yasuo Tsutsumi1* 1 Osaka University, Japan, 2 National Institute of Biomedical Innovation (NiBio), Japan P2-222 Not only Trichloroethylene but also Trichloroethanol May Have Sensitizing Potential in Guinea Pig Hisao Naito1, Yui Hibino1, Na Zhao2, Hongling Li2, Xiangrong Song2, Lili Liu2, Yongshun Huang2, Hailan Wang2, Yuki Ito3, Michihiro Kamijima2 and Tamie Nakajima4* 1 Nagoya University Graduate School of Medicine, Japan, 2 Guangdong Province Hospital for Occupational Disease Prevention and Treatment, China, 2 Nagoya City University Graduate School of Medical Sciences, Japan, 4 Chubu University College of Life and Health Sciences, Japan P2-223 The Protective Effects of SOD-Enriched Rosa Roxburghii Tratt Juice on Cellular Immune Function in Arsenism Patients Caused by Coal Burning Jun Li1, Ai H Zhang1*, Yu J Ren2, Xue X Dong2 and Xiao X Huang2 1 School of Public Health, Guiyang Medical University, China, 2 The 44th Hospital of PLA, China P2-224 Immunosuppressive Properties of Peptidyl-ﬂ uoromethyl Ketones and the Role of Caspases During T Cell Activation and Proliferation Tanuja Rajah Monash University, Malaysia P2-225 Delayed-Type Hypersensitivity (DTH) Model in the Cynomolgus Monkey Jean-Francois Le Bigot1, Caroline Bouchez1, Frederic Gervais1, Renaud Fleurance1, Bernard Palate1 and Jacques Descotes2 1 CiToxLAB France, France, 2 Poison Center, France P2-226 Modulatory Effect of Walnut (Juglans Regia L.) Extract on Deltamethrin-induced Immunosuppression in Mice Hasibur Rehman1*, Firoz Ahmad2, Suhel Parvez2 and Sheikh Raisuddin2 1 University of Tabuk, Saudi Arabia, 2 Jamia Hamdard, India P2-227 The Role for TAK1 in the TCE-Induced Contact Hypersensitivity Response Yao Pan, Jintao Yang, Hongpeng Huang, Qiuqiong Tang, Jianjun Jiang, Lanqin Shang, Shuang Wu and Weidong Hao* Peking University, China P2-228 Neuronal NADPH Oxidase Plays a Critical Role in Neuroinﬂ ammation-induced Chronic Dopamine Neurodegeneration Hui Zhou* Peking University, China P2-229 Modulation of Mucin mRNA (MUC5AC and MUC5B) Expression, Protein Production and Secretion in Caco-2/ HT29-MTX Co-cultures Following Exposure to Individual and Combined Fusarium Toxins Lam Yim Murphy Wan1, Kevin Allen2, Paul C Turner3 and Hani El- Nezami1* 1 The University of Hong Kong, Hong Kong, 2 University of British Columbia, Canada, 3 University of Maryland, USA P2-230 IgE Antibody Responses, Endotoxin and Allergenicity Assessment Rebecca Dearman1*, Scott Mcclain2 and Ian Kimber1 1 University of Manchester, United Kingdom, 2 Syngenta, USA P2-231 Positive Relationship between Allergic Parameters in Korean Swine Farm Workers and Endotoxin Level in Respirable Uust Ji Youn Kim1, Hyoung Ah Kim2, So Ryeon Hwang1, Kyeong Uk Yeo1, Ji Hoon Jo1, Kyeong Min Shin1, Jae Hee Lee1 and Yong Heo1* 1 Catholic University of Daegu, Korea, 2 The Catholic University of Korea, Korea P2-232 Induction of Mast Cell Degranulation by Triterpenoidal Saponins Obtained Ji-Yoon Choi Korea University, Korea The XIII International Congress POSTER / JULY 2 (TUE) 89 of Toxicology

P2-233 Downregulation of Respiratory Allergic Response in Mice Reared under Non-speciﬁ c Pathogen Free Conditions Jong Soon Kang1, So Ryeon Hwang2, Hyoung-chin Kim1 and Yong Heo2* 1 Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Korea, 2 Catholic University of Daegu, Korea P2-234 Fermented Fish Oil Restrains the Immoderate T Helper Cells Response in the Allergic Dermatitis Mouse Model via the Generation of CD25+Foxp3+ T Cells Sang-Chul Han1, Dong-Hwan Koo1, Na-Jin Kang1, Hee-Kyoung Kang1, Sang-Wook Moon2 and Eun-Sook Yoo1* 1 Jeju National University, Korea, 2 Fermentec Inc, Korea P2-235 Association between Immunological Biomarkers and Job Stress Depending on Perceived Stress Level among Female Nurses Hyung-Suk Yoon1, Kyoung-Mu Lee2, Sohee Han1, Minkyo Song1, Jae Jeong Yang1 and Daehee Kang1* 1 Seoul National University, Korea, 2 Korea National Open University, Korea P2-236 Acute Toxic Responses of the Rockﬁ sh (Sebastes Schlegeli) to Iranian Heavy Crude Oil Hana Kim, Young-Sun Chae, Won-Joon Shim and Jee Hyun Jung* Korea Institute of Ocean Science & Technology, Korea P2-237 Molecular Cloning and Expression Analysis of Rock Bream (Oplegnathus Fasciatus) Lipopolysaccharide- induced TNF-a Factor (LITAF) Young-Sun Chae1, Hana Kim1*, Ju-Won Kim2, Seong-Don Hwang2, Jee-Hyun Jung1, Won-Joon Shim1 and Chan-Il Park2* 1 Korea Institute of Ocean Science & Technology, Korea, 2 Gyeongsang National University, Korea P2-238 Immunotoxicity of Some Pesticides in Egyptian Diabetic Children Doaa El Morsi Manoura University, Egypt P2-239 Negative Regulation of B Cell-activating Factor by Mucosal Ribosome-inactivating Stress Kee Hun Do1, Dongwook Kim2, Beob Gyun Kim3 and Yuseok Moon1* 1 Pusan National University School of Medicine, Korea,2 National Institute of Animal Science, RDA, Korea, 3 Konkuk University, Korea

P2-240 ~ 254 : Industrial Toxicity P2-240 Comparative Study for Gelatin Extraction by Li2CO3 from Different Leather Wastes Ola Mohamed and Ghada Taha National Research Center, Egypt P2-241 Impact of Occupational Lead Exposure on Enzymatic Markers among Glass Industry Workers in Firozabad, India Nrashant Singh1*, Narendra K Raghav2, Bhoopesh K Sharma1 and Jyoti Singh1 1 Amity University, India, 2 S. N. Medical College, India P2-242 The Investigation of Chromosome Damage in Inhabitants who Exposure to Air Pollution at Map Ta Phut Industrial Complex, Thailand Phongpan Mokmued1, Kwanyuen Sripaoraya1, Jeerapha Silaket1, Suleeporn Sangrajrang1, Chaniphun Butryee2, Chardwut Jumjod1 and Sumol Pavittranon1* 1 Ministry of Public Health, Thailand, 2 Mahidol University, Thailand P2-243 Toxicological Evaluations of Rare Earths and Their Health Impacts to Workers Kyung-Taek Rim Korea Occupational Safety and Health Agency, Korea P2-244 Combined Subchronic Hepatotoxicity of Toluene and Dimethylformamide in Rats Yong Hyun Chung and Ki Woong Kim* Occupational Safety and Health Research Institute, Korea P2-245 Histopathological Changes of the Lung of Rats after Intratracheal Instillation Exposure to Korea Chrysotile and Anthophyllite Asbestos Yong Hyun Chung*, Jeong Hee Han and Min Gu Kang Occupational Safety & Health Research Institute, Korea The XIII 90 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-246 Microarray and Comet Assay of the Rare Earth Metals, Lanthanum Oxide and Neodymium Oxide in Vitro Kim Jong-Kyu, Kim Soo-Jin and Rim Kyung-Taek* Occupational Safety and Health Research Institute, Korea P2-247 Study on the Mortality Rate Following Oxygen Concentration Using SD Rats Hyeon-Yeong Kim, Sung-Bae Lee and Jeong-Hee Han Korea Occupational Safety and Health Agency, Korea P2-248 Analysis Method of Colorants in Children's Products Using HPLC/DVD Su Yeong Lee, Kwang Seol Seok, Ki Bong Song, Hyuk Kim, Ki Tae Sim and Yu Jeong Yang National Institute of Environmental Research, Korea P2-249 Analysis Method of TCE&PCE in Children's Products Yu Jeong Yang, Kwang Seol Seok, Ki Bong Song, Hyuk Kim, Su Yeong Lee and Ki Tae Sim National Institute of Environmental Research, Korea P2-250 Analysis Method of Perservatives in Children's Products Using GC/MS Ki Tae Sim, Kwang Seol Seok, Ki Bong Song, Hyuk Kim, Su Yeong Lee and Yu Jeong Yang National Institute of Environmental Research, Korea P2-251 Differences in Biological Exposure Indices of Each Process of ITO Target Manufacturers in Korea Yong Lim Won*, Gwang Yong Yi, Hyeon-Yeong Kim, Mi-Young Lee and Eun-A Kim* Occupational Safety and Health Research Institute, Korea P2-252 Safe Limits Concentration of Ammona Gas in Work Environment through Expression CD4, CD8 and IL2 Abdul R Tualeka Airlangga University, Indonesia P2-253 Status of Lead Exposure, Hematological Parameters, and Neurocognitive States in Workers of a Battery Making Industry Ali Akbar Malekirad1, Mohammad Abdollahi1 and Razieh Kalantari-Dehaghi2 1 Tehran University of Medical Science, Iran, 2 Esfahan University of Medical Science, Iran P2-254 The Relationships between Mental Health Status, Achievement Motivation, Job Satisfaction and Oxidative Stress in Subjects Exposed to Nickel Welding Fumes Ali Akbar Malekirad1, Mohammad Abdollahi2 and Gholamhassan Vaezi3* 1 Payame Noor University, Iran, 2 Tehran University of Medical Science, Iran, 3 Islamic Azad University, Iran

P2-255 ~ 269 : Infl ammation P2-255 FIP-fve, an Immunomodulatory Protein from Flammulina Velutipes, Inhibits Infl ammation Induced by Respiratory Syncytial Virus Yu-Chi Chang Chung Shan Medical University, Taiwan P2-256 The Analysis of Infl ammatory Response to Nano- and Sub-Nano-Silver Particles in Human Macrophage Like Cells, THP-1 Nobuo Nishijima1, Yasuo Yoshioka1*, Toshiro Hirai1, Hideki Takahashi1, Koichi Ichihashi1, Shin-Ichi Tsunoda2, Kazuma Higashisaka1 and Yasuo Tsutsumi1* 1 Osaka University, Japan, 2 National Institute of Biomedical Innovation, Japan P2-257 Infl ammatory Genes Are Major Targets of Persistent Organic Pollutants in Adipose Cells Min Ji Kim1, Veronique Pelloux2, Erwan Guyot1, Joan Tordjman2, Linh-Chi Bui1, Aline Chevallier1, Claude Forest1, Chantal Benelli1, Karine Clement2 and Robert Barouki3* 1 INSERM U747, Universite Paris Descartes, France, 2 INSERM U872, Nutriomique Team 7, Universite Paris 6, Centre de Recherche des Cordeliers, France, 3 INSERM U747, Universite Paris Descartes, Sorbonne Paris Cite, AP-HP Hopital Necker- Enfants Malades, France P2-258 Anti-arthritic and Immunosuppressive Activities of Substituted Triterpenoidal Candidates Mohamed A Al-Omar King Saud University, Saudi Arabia The XIII International Congress POSTER / JULY 2 (TUE) 91 of Toxicology

P2-259 Increase of Inhibitory Activity against TACE (Tumor Necrosis Factor- α Converting Enzyme) by Food- Derived Peptides Occurring in Human Peripheral Blood Eun Young Park*, Tomomi Fujikawa, Yasushi Nakamura and Kenji Sato Kyoto Prefectural University, Japan P2-260 Chronic Obstructive Pulmonary Disease and Infl ammatory Biomarkers in Workers Exposed to Inorganic Dusts Jin-Ha Yoon, Joo-Hwan Hwang*, Jae-Hoon Shin, Byung-Soon Choi, You-Lim Lee and Jong-Sung Lee Occupational Lung Diseases Institute, Korea P2-261 The Involvement of Reactive Oxygen Species Overproduction and Mitochondrial Dysfunction in Brominated Diphenyl Ether-47-induced Infl ammation in Human Extravillous Trophoblasts Hae-Ryung Park and Rita Loch-Caruso* University of Michigan, USA P2-262 The Inhibitory Effect of Creamium Boydenii, a Red Algae, on MDC/CCL22 Production through STAT1 Phosphorylation in IFN-gamma and TNF-alpha-stimulated HaCaT Keratinocyte Na-Jin Kang, Gyeoung-Jin Kang, Sang-Chul Han, Dong-Hwan Koo, Eun-A Hyun, Young-Sang Koh, Hee-Kyoung Kang and Eun-Sook Yoo* Jeju National University, Korea P2-263 Anti-infl ammatory Effect of Compound a Isolated from Ecklonia cava in Interferon-γ-induced HaCaT Keratinocyte Dong-Hwan Koo1, Sang-Chul Han1, Na-Jin Kang1, Nam-Ho Lee1, Young-Sang Koh1, Jin-Won Hyun1, Mi-Hee Ko2, Hee-Kyoung Kang1 and Eun-Sook Yoo1* 1 Jeju National University, Korea, 2 Jeju Biodiversity Research Institute, Jeju Technopark, Korea P2-264 Blood Pressure Lowering Effect of the Glycosaminoglycan Derived from Isaria Sinclairii in SHR Rats Mi Young Ahn1*, Yi Sook Jung2, Sang Duck Jee1, Jae Sam Hwang1, Eun Young Yun1 and Byung Mu Lee3 1 National Academy of Agricultural Science, RDA, Korea, 2 Ajou University, Korea, 3 Sungkyunkwan University, Korea P2-265 Neutrophil Count as a Potential Cancer Susceptibility Marker Aesun Shin, Jeonghee Lee and Jeongseon Kim Molecular Epidemiology Branch, National Cancer Center, Korea P2-266 Radicicol Inhibits iNOS Expression in Cytokine-stimulated Pancreatic Beta Cells Min Lee and Young Jeon* Chosun University College of Medicine, Korea P2-267 Resolvin D1-mediated NOX2 Inactivation Rescues Macrophages Undertaking Efferocytosis from Oxidative Stress-induced Apoptosis Ha-Na Lee and Young-Joon Surh* Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Korea

12,14 P2-268 15-Deoxy-△ -prostaglandin J2 Exerts Pro-resolving Effects through Activation of Nrf2-mediated CD36 Expression in Murine Macrophages Kim Wonki, Lee Ha-Na and Surh Young-Joon* Tumor Microenvironment Global Core Research Center, Seoul National University, Korea P2-269 Anti-paw Edema Effect of Glycosaminoglycan from G. Bimaculatus on Adjuvant Treated Chronic Arthritis Rat Model Mi Young Ahn*, Jae Sam Hwang and Eun Young Yun National Academy of Agricultural Science, RDA, Korea

P2-270 ~ 289 : Inhalation and Pulmonary Toxicology P2-270 Occupational Chronic Obstructive Pulmonary Diseases Frederic J Deschamps Medicine Faculty, France The XIII 92 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-271 Effects and Mechanisms of Radon Exposure on Apoptosis of V79 Cells in Vitro Jian-Xiang Li1, Ye Wei1, Yue-Jin Chen1, Yu-Ping Liu1 and Gui-Xiang Zhang2 1 Soochow University, China, 2 Hope Industry&Trade Co., Ltd, China P2-272 Inhalation of Aerosolized Zinc Oxide Nanoparticles Induced Adverse Effects in Mice: Comparison with Submerged and Air-liquid Interface Exposure of Lung Epithelial Cells Jen-Kun Chen1, Chia-Hua Lin1, Chia-Chi Ho2 , Han Chang4, Chung Shi Yang1, Ming-Hsien Tsai1, Hui-Ti Tsai1 and Pinpin Lin1* 1 National Health Research Institutes, Zhunan, Taiwan, 2 National Tsing Hua University, Taiwan, 4 China Medical University, Taiwan P2-273 The Weight of Smoke: Assessment of Tobacco Smoke Particle Deposition in Vitro Using Vitrocell® Quartz Crystal Microbalance Technology Jason Adamson*, David Thorne, Annette Dalrymple, Clive Meredith and Debbie Dillon British American Tobacco, United Kingdom P2-274 Use of Antibody Arrays to Monitor Acrolein-Induced Changes in Gene Expression in Calu-3 Lung Cell Monolayers Philip Burcham, Albert Raso and Peter Henry University of Western Australia, Australia P2-275 Protective Effect of Metallothionein on Paraquat-Induced Acute Lung Injury in Mice Yi-Mei Wang, Ming Ren, Jun Zhao, Zeng-Ming Zhao, Ting-Fen Zhang, Jun He and Shuang-Qing Peng* Institute of Disease Control and Prevention, Academy of Military Medical Sciences, China P2-276 The Impact of the Pollution Control Measures for the 2008 Beijing Olympic Games on the Metal Composition and the Cytotoxicity of PM2.5 Hongying Wei, Furong Deng and Xinbiao Guo* Peking University, China P2-277 Ellagic Acid Ameliorates Bleomycin and Cyclophosphamide Induced Pulmonary Toxicity in Male Rats Saba Saba* Jamia Hamdard University, India P2-278 Variation in mRNA Levels of TRPA1 and TRPV1 in Human Airway Tissues Toshiko Tanaka-Kagawa, Yoko Okamoto, Kaori Mayumi, Maiko Tahara, Yoshiaki Ikarashi and Hideto Jinno* National Institute of Health Sciences, Japan P2-279 Aetiological Diagnosis of Haemoptysis in the Dhaka Medical College and Hospital of Bangladesh: A Prospective Study among the Admitted Patients Md. Ariful Haque Mollik* Peoples Integrated Alliance, Bangladesh P2-280 Isothiazolinone Preservatives Activate the Sensory Ion Channels Human TRPA1 and TRPV1 Hideto Jinno1*, Susumu Ohkawara2, Yoko Okamoto1, Kaori Mayumi1, Maiko Tahara1, Yoshiaki Ikarashi1 and Toshiko Tanaka-Kagawa1 1 National Institute of Health Sciences, Japan, 2 Kyushu University of Health and Welfare, Japan P2-281 Subacute Inhalation Toxicity Assessment of Chloramine T in Sprague-Dawley Rats Ilseob Shim, Hyunmi Kim, Jungtaek Kwon, Gyunbaek Seo, Mimi Lee, Pilje Kim and Kyunghee Choi National Institute of Environmental Research, Korea P2-282 Inhalation Exposure of Rats to Commercial Humidiﬁ er Disinfectants Induced Fatal Bronchiolitis with Fibrosis Seong-Jin Choi1, Yongju Heo1, Sanghyub Lee1, Jeong-Ah Song1, Yong-Bum Kim2, Yong-Hwa Kim2, Chang-Woo Song2 and Kyuhong Lee1* 1 Inhalation Toxicology Center, KIT, Korea, 2Korea Institute of Toxicology, KRICT, Korea P2-283 Polyhexamethyleneguanidine Phosphate Induces Pulmonary Fibrosis through Signaling Activation of NALP3 Inﬂ ammasome Jeong Ah Song, Kyung Jin Jung, Hyo-Seon Yang, Mi-Jin Yang, Moon Koo Chung, Chang-Woo Song and Kyuhong Lee* Korea Institute of Toxicology, KRICT, Korea The XIII International Congress POSTER / JULY 2 (TUE) 93 of Toxicology

P2-284 Rat inhalation Toxicity of Diesel Exhaust Hyun Mi Kim*, Il Seob Shim, Kyun Baek Seo, Jung Taek Kwon, Mimi Lee, Phil Je Kim and Kyunghee Choi National Institute of Environmental Research, Korea P2-285 The Fogucid Induces in Vitro Pulmonary Toxicity Chang-We Park, Da-Young Shin, Ha-Ryong Kim and Kyu-Hyuck Chung* Sungkyunkwan university, Korea P2-286 Overexpression of Apolipoprotein A1 in the Lung Abrogates Fibrosis in Experimental Silicosis Sungwoo Park*, Eun Hee Lee, Chorong Kim, An Soo Jang and Choon-Sik Park Soonchunhyang University Bucheon Hospital Internal Medicine, Korea P2-287 Levels of Hydrogen Peroxide Corrected by Urea as Dilution Factor in BAL Fluid of Rats Exposed to MWCNT for 28 Days Jong Seong Lee1, Jae Hoon Shin1, Ju Hwan Hwang1, Byung-Soon Choi1, Jae Hyuck Sung2, Kyung Seuk Song2 and Il Je Yu3* 1 Occupational Lung Diseases Institute, KCOMWEL, Korea, 2 BioConvergence Technology Laboratory, KCL, Korea, 3 Institute of Nano Products Safety Research, Hoseo University, Korea P2-288 Comparative Study of Cytotoxic Effects of Asbestos Fibers on Pulmonary Fibroblast based on a Real-time Cell Analysis Combined with Cytomorphologic Imaging Analysis Tae-Jung Kim1*, Seunghye Yu2, Il Won Kim2, Eun Jung Lee1 and Chang Suk Kang1 1 The Catholic University of Korea, Korea, 2 Soongsil University, Korea P2-289 Evaluation of Antiasthmatic Activity of 7,8,9, 10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one in Combination with Ambroxol in Guinea Pigs Rohit Goyal* Shoolini University, India

P2-290 ~ 334 : Metal Toxicity P2-290 Awareness of Harmful Effects of Mercury in Healthcare Set Up in India: a Survey Based Study Sharda S Peshin, Nabanita Halder and Yogendra K Gupta Department of Pharmacology, All India Institute of Medical Sciences, India P2-291 Cadmium Chloride Induces Apoptosis in Human Breast Cancer Cell Line (Mcf-7) through Ros-Dependent Mojtaba Panjehpour, Ali Khojastehfar, Mahmoud Aghei and Marjan Gharagozloo Isfahan University of Medical Sciences, Iran P2-292 Involvement of Nitric Oxide and Metallothionin in Cadmium-induced Cytotoxicity and Resistance in Caco-2 cells Farzaneh Malekmarzban, Mohammad Seyedabadi, Mohammad H Ghahremani, Shohreh Tavajohi and Seyed N Ostad* Tehran University of Medical Sciences, Iran P2-293 Diphenylarsinic Acid Promotes the Glutaminase C Degradation by Mitochondrial Lon Protease Kayoko Kita*, Toshihide Suzuki and Takafumi Ochi Teikyo University, Japan P2-294 The Function of TEX27 on Reduction of Methylmercury toxicity Seong-Eun Oh, Gi-Wook Hwang and Akira Naganuma* Tohoku University, Japan P2-295 Chromium and Lead in Lipstick Amalia E Hidayat and Annisa Sukmasari University of Indonesia, Indonesia P2-296 Chronic Exposure to Cadmium Induces p53-dependent Apoptosis Speciﬁ cally in Renal Tubules of Mice Jinyong Lee1, Maki Tokumoto2, Yasuyuki Fujiwara1 and Masahiko Satoh1 1 Aichi Gakuin University, Japan, 2 Showa Pharmaceutical University, Japan P2-297 Inhibitory Effect of Cadmium on the Expression of Iron Transport-related Genes Yasuyuki Fujiwara and Masahiko Satoh* Aichi Gakuin University, Japan The XIII 94 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-298 Effects of Arsenic on Expressions of Ube2d Family and Accumulation of p53 in NRK-52E Cells and HK-2 Cells Masahiko Satoh1*, Jin-Yong Lee1, Maki Tokumoto2, Yasuyuki Fujiwara1 and Chiho Watanabe3 1 Aichi Gakuin University, Japan, 2 Showa Pharmaceutical University, Japan, 3 University of Tokyo, Japan P2-299 Involvement of p53 on Cadmium-induced Apoptosis in Human Proximal Tubular Cells Maki Tokumoto1, Jin-Yong Lee2, Yasuyuki Fujiwara2 and Masahiko Satoh2* 1 Showa Pharmaceutical University, Japan, 2 Aichi Gakuin University, Japan P2-300 Determination of V and Mn in Rat Kidney by Inductively Coupled Plasma-Mass Spectroscopy Liliana V Saldivar, Rafael Leon, Maria G Espejel, Hebe Garcia, Maria T Rodriguez and Teresa I Fortoul Universidad Nacional Autonoma de Mexico, Mexico P2-301 Relationship Between the Esterase Paraoxonase-1 (PON1) and Metal Concentrations in the Whole Blood of Inuit in Canada Laurie H Chan1*, Brian D Laird1 and Pierre Ayotte2 1 University of Ottawa, Canada, 2 Laval University, Canada P2-302 Interaction between Fluoride and Arsenic on Bone Metabolism Markers in Chinese Population Qi-Bing Zeng and Feng Hong* Guiyang Medical University, China P2-303 Methylmercury Induces a Brain-Specifi c Increase in Chemokine CCL3 and CCL4 Expression in Mice Min-Seok Kim1, Jin-Yong Lee2, Tsutomu Takahashi1, Gi-Wook Hwang1 and Akira Naganuma1* 1 Tohoku University, Japan, 2 Aichi Gakuin University, Japan P2-304 Assessment of Chromium and Nickel Levels in Maternal Blood, Placenta and Cord Blood by Graphite Furnace Atomic Absorption Spectrometry Enes Arica*, Zeliha Kayaalti, Dilek Kaya Akyuzlu and Tulin Soylemezoglu Ankara University Institute of Forensic Sciences, Turkey P2-305 Chronic Use of Ayurvedic Herbometallic Preparation: Experimental Evidence on Safety Yogendra K Gupta1, Gajendra Kumar1, Amita Srivastava1 and Surinder K Sharma2 1 All India Institute of Medical Sciences, India, 2 Ayurvedic Phamacoepia Committee, Government Of India, India P2-306 Molecular Mechanism by which Homeobox Protein HOX-B13 Augments Methylmercury Toxicity in HEK293 Cells Ryo Nakano, Gi-Wook Hwang and Akira Naganuma* Tohoku University, Japan P2-307 Effects of Chronic Exposure to Elemental Mercury on Immunological Biomarkers in Artisanal Gold Mining Settings: Cross Sectional Study in Colombia Laura A Rodriguez Villamizar, Xiomara Gonzalez Serrano, Oscar Florez Vargas, Luz Y Vargas Fiallo and Luz H Sanchez Rodriguez* Universidad Industrial de Santander, Colombia P2-308 Effects of Elemental Mercury Vapour on Renal Function in Artisanal Gold Mining Settings Luz H Sanchez Rodriguez*, Lina M Florez, Oscar Florez Vargas, Laura A Rodriguez Villamizar and Luz Y Vargas Fiallo Universidad Industrial de Santander, Colombia P2-309 Metabolomic Analysis in Cerebellum of Mice treated with Methylmercury and Elucidation of Toxicological Signifi cance of Identifi ed Metabolites Masayuki Sato, Gi-Wook Hwang and Akira Naganuma* Tohoku University, Japan P2-310 Infl uence of Arsenic Exposure on Cell Immune System in Endemic Arseniosis Patients from Guizhou, China Aihua Zhang1*, Junying Gu1, Bixia Zhang2 and Xiaoxin Huang2 1 Guiyang Medical University, China, 2 The 44th Hospital of PLA, China P2-311 Effect of Injection Timing on Cd-induced Testicular Toxicity in Mice Katsumi Ohtani1, Yukie Yanagiba1, Masako Togawa2, Tatsuya Hasegawa2 and Nobuhiko Miura1* 1 National Institute of Occupational Safety and Health, Japan, 2 Yamanashi Institute Environmental Sciences, Japan The XIII International Congress POSTER / JULY 2 (TUE) 95 of Toxicology

P2-312 Chromium (VI)-induced Transformation is Enhanced by Zinc Defi ciency in BALB/3T3 Clone A31-1-1 Cells Tomoki Kimura1*, Akira Onodera2, Takuomo Hosaka1, Tsuyoshi Nakanishi3, Norio Itoh2 and Masakazu Isobe1 1 Setsunan University, Japan, 2 Osaka University, Japan, 3 Gifu Pharmaceutical University, Japan P2-313 Trimethyltin Chloride Exposure Chronically and the Risk of Developing Xiaojiang Tang* Guangdong Medical Laboratory Animal Center, China P2-314 Impacts of Prenatal Arsenic Exposure on DNA Methylation in Human Cord Blood Lymphocytes Panida Navasumrit, Pornpat Intarasunanont, Somchamai Waraprasit, Krittinee Chaisattra, Jeerawan Promvijit and Mathuros Ruchirawat* Chulabhorn Research Institute, Thailand P2-315 Arsenic Alters Cholinergic System in Neuronal and Non-neuronal Cancer Cells Tawit Suriyo and Jutamaad Satayavivad* Chulabhorn Research Institute, Thailand P2-316 Exposure Levels of Arsenic in the Nail, Hair, Urine and Drinking Water among Cambodian People Living in Arsenic-polluted Areas Hideki Miyataka1, Harue Morita1, Suthipong Sthiannopkao2 and Seiichiro Himeno1 1 Tokushima Bunri University, Japan, 2 Dong A University, Korea P2-317 Determination of Hexavalent Chromium from a Color Packaging Bought in Thailand Market Kieatsuda Poouthree* Ministry of Science and Technology, Thailand P2-318 Tissue Changes in the Internal Organs of Chromium Exposure Jamal E Ben Zeglam1 and Krizan Culjak2 1 University of Tripoli, Libya, 2 University of Zagreb, Croatia P2-319 Infl uence of Aluminium Chloride on Plasma Membrane Enzymes and Antioxidants in the Testis and Epididymis of Rats Ramalingam Venugopal, Kalaiselvi Arumugam, Vasantharaja Dhasal and Gowri Balaji Pondicherry University, India P2-320 Adverse Effect of Aluminium on Secretory Products and Lipid Profi le in the Epididymis and Spermatozoa of Rats Kalaiselvi Arumugam, Vasantharaja Dhasal, Gowri Balaji and Ramalingam Venugopal Kanchi Mamunivar Centre for Post Graduate Studies, India P2-321 Lead and Cadmium Contents of Some Brands of Cigarettes in Nigeria: Effects on Liver Function Indices and Total Prostate Specifi c Antigen(t-PSA) as an Indicator of Hyperplasia in Smokers in a Nigerian Ishiaq O Omotosho1* and Bunmi I Ogunsiji2 1 University of Ibadan, Nigeria, 2 Achiever's University, Nigeria P2-322 Alteration of MARCKS Expression and Phosphorylation Levels by Methylmercury Mitsuya Shiraishi1*, Makoto Hangai1, Megumi Yamamoto2, Atsuhiro Tanabe3 and Atsushi Miyamoto1 1 Kagoshima University, Japan, 2 National Institute for Minamata Disease, Japan, 3 Shibaura Institute of Technology, Japan P2-323 Studies on the Seasonal Variation of Different Water Quality Parameters in the Tulshiganga and Nagar Rivers of Bogra District within Bangladesh Md. Ariful Haque Mollik* Peoples Integrated Alliance, Bangladesh P2-324 Adverse Effect of Nanosized Titanium Dioxide on Testicular Function in Mice Nobuhiko Miura*, Katsumi Ohtani, Tetsuya Suzuki, Yukie Yanagiba, Rieko Hojo, Megumi Suda, Muneyuki Miyagawa and Rui-Sheng Wang Japan National Institute of Occupational Safety and Health, Japan P2-325 Interplay of Manganese and Iron in Dopaminergic Oxidative Stress Takao Tobe, Hideaki Hayami, Yuma Hoshino, Koji Ueda, Yoshinori Okamoto and Nakao Kojima* Meijo University, Japan The XIII 96 POSTER / JULY 2 (TUE) International Congress of Toxicology

P2-326 Low Level of Lead Can Induce Phosphatidylserine Exposure and Erythrophagocytosis: a New Mechanism Underlying Lead-Associated Anemia Won-Hee Jang1, Kyung-Min Lim2, Keunyoung Kim1, Ji-Yoon Noh1, Seojin Kang1 and Jin-Ho Chung1* 1 Seoul National University, Korea, 2 Ehwa Womans University, Korea P2-327 Molecular and Genomic Approach for Understanding the Gene-Environment Interaction between Nrf2 Defi ciency and Carcinogenic Nickel-Induced DNA Damage Seung Hun Kang and Young Rok Seo* Dongguk University, Korea P2-328 A Follow-up Study on the Concentration Change of Heavy Metals in Urine of Residents 3 Years after the Hebei Spirit Oil Spill Jung Ah Kim1, Su Ryeon Noh1, Gwi Heum Eom1, Hyun Sook Bae1, Seon Young Ka1, Young-Hyun Choi1, Mina Ha2* and Hae-Kwan Cheong3* 1 Taean Environmental Health Center, Korea, 2 Dankook University College of Medicine, Korea, 3 Sungkyuonkwan University School of Medicine, Korea P2-329 Environmental Cadmium Exposure Induce Tubular Damage in the Kidneys of General Population in Korea Sang-Yong Eom1, Byung-Sun Choi2, Dong-Kyeong Kim2, Young-Seoub Hong3, Seok-Joon Sohn4, Heon Kim1, Kyung-Soo Park5, Hee-Soo Pyo5, Ho-Jang Kwon6 and Jung-Duck Park2* 1 Chungbuk National University, Korea, 2 Chung-Ang University, Korea, 3 Dong-A University, Korea, 4 Chonnam National University Medical School, Korea, 5 Korea Institute of Science and Technology, Korea, 6 Dankook University, Korea P2-330 Study on Accurate Analysis of Chromium with Inductively Coupled Plasma Mass Spectrometry Seungha Lee, Ji Ae Kim, Seunghyun Choi and Dalwoong Choi* Korea University, Korea P2-331 Mixture Toxicity of Five Heavy Metals: Arsenic, Cadmium, Chromium, Mercury and Mickel in SD Rats and Detoxifi cation by Citric Acid Young Woo Kim, Hyung Sik Kim and Byung-Mu Lee* Sungkyunkwan University, Korea P2-332 Arsenic Hazardous Quotient in Males Lived in Arsenic Contaminated and Non Contaminated Areas Jameel A Baig International Islamic University, Pakistan P2-333 The Effect of Cinnamomum Zeylanicum and Vaccinium Myrtillus on DNA Damage and Myeloperoxidase Activity in Workers Exposed to Welding Fumes Gholamhassan Vaezi1, Ali Akbar Malekirad2*, Neda Baghinia3 and Mohammad Abdollahi4 1 Islamic Azad University, Iran, 2 Payame Noor University, Iran, 3 Islamic Azad University and Damghan Branch, Iran, 4 Tehran University of Medical Science, Iran P2-334 Arsenic-induced Perturbations in the Certain Tissues of Nutritionally Important Catfi sh Clarias batrachus (Linn.) and Its Recovery Randhir Kumar and Tarun K Banerjee Banaras Hindu University, India The XIII International Congress POSTER / JULY 3 (WED) 97 of Toxicology

P3-001 ~ 051 : Nanotoxicology P3-001 The Antibacterial Effect of TiO2, SiO2 and Ag Nanoparticles on S. Aureus under Different pH, Ionic Strength and Light Conditions Merve Ozkaleli and Ayca Erdem Akdeniz University, Turkey P3-002 Silver Nanotoxicology: a Novel, Non-invasive Electrophysiology Technique & the Potential Role of P-glycoprotein in Modulating Silver Nanoparticle Toxicity in Earthworms and Aquatic Oligochaetes Ravi Gooneratne, Noemie Demizieux, Longfei Mao and Martin Wellby Lincoln University, New Zealand P3-003 The Effect of Fullerene C60 Derivatives on Acquired Immune System Asako Udaka1, Yasuo Yoshioka1, Toshiro Hirai1, Shin-Ichi Tsunoda2, Hisae Aoshima3, Ken Kokubo1, Takumi Oshima1, Tomoyuki Ohe4, Tadahiko Mashino4, Kazuma Higashisaka1 and Yasuo Tsutsumi1 1 Osaka University, Japan, 2 National Institute of Biomedical Innovation, Japan, 3 Vitamin C60 BioResearch Corporation, Japan, 4 Keio University, Japan P3-004 The Particle Size of Nanomaterial Might be Determinant of the Protein Corona on the Cytotoxicity Michihiko Aoyama1, Yasuo Yoshioka1, Kohei Yamashita1, Mayu Taira1, Tokuyuki Yoshida1, Shin-Ichi Tunoda2, Kazuma Higashisaka1 and Yasuo Tsutsumi1* 1 Osaka University, Japan, 2 National Institute of Biomedical Innovation, Japan P3-005 Carbon Nanotubes - a New Criteria Document from the Nordic Expert Group Gunnar Johanson1*, Anna-Karin Alexandrie2 and Jill Jarnberg2 1 Karolinska Institutet, Sweden, 2 Swedish Work Environment Authority, Sweden P3-006 Attenuation of Th17 Cell Reactivity in Vitro and in Vivo by Iron Oxide Nanoparticles Tong-Rong Jan1* and Hong-Jen Liang2 1 National Taiwan University, Taiwan, 2 Yuanpei University, Taiwan P3-007 Absorption and General Toxicity of Sub-nano Platinum Particles following Dermal Exposure Ko-Ichi Ichihashi1, Yasuo Yoshioka1*, Toshiro Hirai1, Hideki Takahashi1, Nobuo Nishijima1, Tokuyuki Yoshida1, Shin-Ichi Tsunoda2, Kazuma Higashisaka1 and Yasuo Tsutsumi1* 1 Osaka University, Japan, 2 National Institute of Biomedical Innovation, Japan P3-008 Toxicity of Zinc Oxide Nanoparticles to Chlorella Vulgaris in the Presence of Chiral Herbicide Dichlorprop Hui Zhou, Xiaojun Wang, Ying Zhou* and Lili Yan Zhejiang University of Technology, China P3-009 Effect of Iron Oxide Nanoparticles on Lipid Proﬁ le and Oxidative Stress Indexes in Serum and Liver of Rat Hossein Najafzadeh1, Maryam Kouchak2*, Naﬁ seh Moslemi1 and Ali Shahriary1 1 Shahid Chamran University, Iran, 2 Ahvaz Jundishapur University of Medical Sciences, Iran P3-010 Synergistic Cytotoxicity of Multi-walled Carbon Nanotubes and Metal Ions Haifang Wang Shanghai University, China P3-011 Biodistribution Analysis of Sub-nano Platinum Focused on the Transfer to the Breast Milk Nao Nojiri1, Yasuo Yoshioka1, Yuki Morishita1, Hiroyoshi Satoh1, Tomohiro Tanaka1, Shin-Ichi Tsunoda2, Kazuma Higashisaka1 and Yasuo Tsutsumi1 1 Osaka University, Japan, 2 National Institute of Biomedical Innovation, Japan P3-012 Biological Assessment of Nanomaterials Focused on Genetic Background Hideki Takahashi1, Yasuo Yoshioka1*, Toshiro Hirai1, Ko-Ichi Ichihashi1, Nobuo Nishijima1, Shin-Ichi Tsunoda2, Tokuyuki Yoshida1, Kazuma Higashisaka1 and Yasuo Tsutsumi1* 1 Osaka University, Japan, 2 National Institute of Biomedical Innovation, Japan P3-013 The Activated Intrinsic Coagulation System Induced by Silica Nanoparticle Kunieda Akiyoshi1, Kazuma Higashisaka1, Tokuyuki Yoshida1, Takashi Nagano1, Yuki Iwahara1, Kota Tanaka1, Katsutomo Hata1, Shin-Ichi Tsunoda2, Yasuo Yoshioka1* and Yasuo Tsutsumi1* 1 Osaka University, Japan, 2 National Institute of Biomedical Innovation, Japan The XIII 98 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-014 Infl ammation Profi le and Gene Expression Status Induced by Intratracheal Instillation of the Multiwall Carbon Nanotube into Rat Lung Masumi Suzui, Shuhei Ikenaga, Yasuaki Isoda, Takamasa Numano, Katsumi Fukamachi, Mitsuru Futakuchi and Hiroyuki Tsuda Nagoya City University, Japan P3-015 In Vitro Genotoxicity of 14 nm Citrate Stabilised Gold Nanoparticles Melissa Vetten*, Jiya George and Mary Gulumian National Institute for Occupational Health, South Africa P3-016 The Effects of Pharyngeal Aspiration Exposure to Zinc Oxide Nanoparticles on Pulmonary Fibrosis Induced by Bleomycin in Mice Wenting Wu1, Gaku Ichihara1*, Saeko Tada-Oikawa2, Yuka Suzuki2, Jie Chang1, Naozumi Hashimoto1, Yoshimori Hasegawa1, Corina Gabazza2, Esteban Gabazza2 and Sahoko Ichihara2 1 Nagoya University Graduate School of Medicine, Japan, 2 Mie University, Japan P3-017 Highly-dispersed, Aggregate/Agglomerate-eliminated Multi-wall Carbon Nanotube Shows Increase in Mesotheliomagenic Potency per Unit Weight in p53 Heterozygous Mice Intraperitoneal Injection Model Yuhji Taquahashi, Yukio Ogawa, Atsuya Takagi, Masaki Tsuji, Akihiko Hirose and Jun Kanno* National Institute of Health Sciences, Japan P3-018 The Role of Silver Ion in Effects of Silver Nanoparticles on Gap Junctional Intercellular Communication between Human Skin Cells Yu Qin, Furong Deng, Hongying Wei, Junhui Xu and Xinbiao Guo* Peking University School of Public Health, China P3-019 Silver Nanoparticles Upregulate Connexin43 and Increase Gap Junctional Communication between Human Skin Cells Furong Deng, Yu Qin, Hongying Wei, Junhui Xu and Xinbiao Guo* Peking University School of Public Health, China P3-020 Comparative Ecotoxocological Assessment of Nanomaterials by in Vitro Screening Tools Younjung Jung*, Seungyun Baik, Jongwoon Kim, Hyunpyo Jeon and Sanghun Kim KIST Europe GmbH Universitaet des Saarlandes Campus, Germany P3-021 Poly-dispersed Single Walled Carbon Nanotubes Down Regulate Allogenic Cytotoxic T Lymphocyte Responses in Vitro and in Vivo Anwar Alam1, Niti Puri1 and Rajiv K Saxena2* 1 Jawaharlal Nehru University, India, 2 South Asian University, India P3-022 Aryl Hydrocarbon Receptor (AhR) Activation by ß-naphthofl avone is Associated with a Decrease in Oxidative Stress Induced by Cu Nanoparticles in H4IIE Cells Mona Connolly, Maria Luisa Fernandez-Cruz and Jose Maria Navas Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA), Spain P3-023 Size-dependent Cytotoxicity of Silver Nanoparticles in Human Lung Cells Anda R Gliga1*, Sara Skoglund2, Inger Odnevall Wallinder2, Bengt Fadeel1 and Hanna L Karlsson1 1 Karolinska Institutet, Sweden, 2 KTH Royal Institute of Technology, Sweden P3-024 Effect of Intravenous Administration of Titanium Dioxide Nanoparticles on Biochemical Changes in the Fresh Water Fish Cyprinus Carpio Vasantharaja Dhasal, Kalaiselvi Arumugam, Gowri Balaji and Ramalingam Venugopal Kanchi Mamunivar Centre for Post Graduate Studies, India P3-025 Particle-size Toxicity of Gold Nanoparticles on the Hepatic and Renal Tissues Bashir M Jarrar Al-Jouf University, Saudi Arabia P3-026 Toxicity Induced by Different Sizes of Silver Nanoparticles on Vital Organs Qais B Jarrar, Abdelkader Battah and Fatima Obeidat University of Jordan, Jordan The XIII International Congress POSTER / JULY 3 (WED) 99 of Toxicology

P3-027 Effect of the Repeated Dose Silica Nanoparticles on Spermatogenic Process in the Male Mice Zhi-Wei Sun* Capital Medical University, China P3-028 Mesothelial Proliferation by MWCNT Translocated from the Lung Alveoli Hiroyuki Tsuda1*, Jiegou Xu1, David B Alexander1, Masumi Suzui1, Akihiko Hiose2 and Jun Kanno2 1 Nagoya City University, Japan, 2 National Institute of Health Sciences, Japan P3-029 Cytotoxicity and Genotoxicity of Silver Nanoparticles and Silver Ions to CHO K1 Cells Xiumei Jiang1*, Rasmus Foldbjerg2, Teodora Miclaus3, Chunying Chen1, Herman Autrup2* and Christiane Beer2 1 Chinese Academy of Science, China, 2 Aarhus University, Denmark, 3 Interdisciplinary Nanoscience Center, University, Denmark P3-030 ZnO Nanoparticles Induce Oxidative Stress and Apoptosis in Human Skin Malignant Melanoma Cell Line-A375 Saud Alarifi King Saud University, Saudi Arabia P3-031 Physicochemical Determinants of Multi-walled Carbon Nanotubes on Cellular Toxicity: Infl uence of Synthetic Method and Post-treatment Ji-Eun Kim and Myung-Haing Cho* Seoul National University, Korea P3-032 Effect of Nanoparticle Size on the Cytotoxicity of Titanium Dioxide on Neuronal Cells in Cell Culture Ayse Basak Engin*, Erdem Coskun, Bensu Karahalil and Ali E Karakaya Gazi University, Turkey P3-033 Toxicity Assessment of Silver Nanoparticles and the Effects of Co-exposure to Silver Nanoparticles and Zinc Sulfate or Manganese (II) Chloride in Human Cancer Cells Ilyoung Ahn Ministry of Food and Drug Safety, Korea P3-034 Functionalization Affects the Zeta Potential, Coronal Stability and Membranolytic Activity of Polystyrene Latex Particles Wan-Seob Cho1, Jeong-Eun Kim1, Frank Thielbeer2, Mark Bradley2 and Ken Donaldson2 1 Dong-A University, Korea, 2 University of Edinburgh, United Kingdom P3-035 Comprehensive Study on Toxicology of Surface-coated ZnO Nanoparticles in Human Alveolar Adenocarcinoma Cells Nirmalya Tripathy, Rafi q Ahmad and Yoon B Hahn* Chonbuk National University, Korea P3-036 The Comparative Effects of Mesoporous Silica Nanoparticles and Colloidal Silica Nanoparticles in Atopic Dermatitis Jin Kyeong Choi and Sang-Hyun Kim* Kyungpook National University, Korea P3-037 A Comprehensive in Vitro and in Vivo Study of ZnO Nanoparticles Toxicity Nirmalya Tripathy1, Tae K Hong2, Rafi q Ahmad1, Han S Jeong2 and Yoon B Hahn1* 1 Chonbuk National University, Korea, 2 Pusan National University, Korea P3-038 Pulmonary Infl ammation Responses after Instillation of Zinc Oxide Nanoparticles Jung-Taek Kwon*, Hyun-Mi Kim*, Gyun-Baek Seo, Mimi Lee, Ilseob Shim, Pilje Kim and Kyung-Hee Choi National Institute of Environmental Research, Korea P3-039 Nanoparticle Pretreatment Alters Cholesterol Distribution in C57BL/6 Mice Junga Lee* and Chaejin Na Kyonggi University, Korea P3-040 Silver Nanoparticles Induce p53-dependent Apoptosis in BEAS-2B Cells Da-Young Shin, Ha-Ryong Kim, Chang-We Park and Kyu-Hyuck Chung* Sungkyunkwan University, Korea P3-041 Biodistribution and Biopersistent of MWCNTs in Rat Lung for 28-Days of Nose-Only Inhalation Exposure Jae Hoon Shin1, Jong Seong Lee1, Joohwan Hwang1, Byung-Soon Choi1, Jae Hyuck Sung2, Kyung Seuk Song2 and Il Je Yu3* 1 Occupational Lung Diseases Institute, KCOMWEL, Korea, 2 Bioconvergence Technology Laboratory, KCL, Korea, 3 Hoseo University, Korea The XIII 100 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-042 In Vitro Toxicity of Stably-nanosized Titanium Dioxide using Polymeric Dispersant in Human Keratinocyte Cells Yeo Jin Kim1, Preeyaporn Koedrith2 and Young Rok Seo1* 1 Dongguk University, Korea, 2 Mahidol University, Thailand P3-043 Incompatibility of Silver Nanoparticles with Lactate Dehydrogenase Leakage Assay for Cellular Viability Test is Attributed to Protein Binding and Reactive Oxygen Species Generation Seok-Jeong Oh, Yingqiu Liu, Jung-Min Park, Jun-Hyeong Lee and Moo-Yeol Lee* Dongguk University, Korea P3-044 Comparison of Respiratory Effects of Nano-sized Carbon Black between Normal and Overweight Rats Cheol-Hong Lim, Mingu Kang and Jeong-Hee Han Occupational Safety and health Research Institute, Korea P3-045 Studies on the Tissue Distribution of Charge Dependent Gold Nanoparticle in Balb/c Mice Jong Kwon Lee1, Tae Sung Kim1, Ji Young Bae1, Sang Min Lee1, A Young Jeong1, Ji Hyun Seok1, Hang Sik Roh1, Yeon Ji Park1, Saet Byul Cho1, Chi Won Song1, Hye Kyung Choi1, Ji Hyun Yun1, Bong Hyun Chung2, Wan-Seob Cho3, Soon Young Han1 and Jayoung Jeong1* 1 Ministry of Food and Drug Safety, Korea, 2 Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Korea, 3 Dong-A University, Korea P3-046 Effect on Inﬂ ammatory Response in Wistar Rat treated with Silicon Dioxide Nanoparticles by Intratracheal Instillation Jong Kwon Lee1, A Young Jeong1, Tae Sung Kim1, Ji Young Bae1 Sang Min Lee1, Ji Hyun Seok1, Hang Sik Roh1, Yeon Ji Park1, Saet Byul Cho1, Chi Won Song1, Hye Kyung Choi1, Ji Hyun Yun1, Wan Sub Cho2, Soon Young Han1 and Jayoung Jeong1* 1 Ministry of Food and Drug Safety, Korea, 2 Dong-A University, Korea P3-047 Effect on Inﬂ ammatory Responses in Rat treated with Different Size of Zinc Oxide Nanoparticles by Intratracheal Instillation Jong Kwon Lee1, Sang Min Lee1, Tae Sung Kim1, A Young Jeong1, Ji Young Bae1, Ji Hyun Seok1, Hang Sik Noh1, Yeon Ji Park1, Saet Byul Cho1, Hye Kyung Choi1, Ji Hyun Yun1, Chi Won Song1, Wan Sub Cho2, Soon Young Han1 and Jayoung Jeong1* 1 Ministry of Food and Drug Safety, Korea, 2 Dong-A University, Korea P3-048 Histopathological Effect of Common carp, Cyprinus carpio during Long-term Exposure to ZnONPs Jae-Woo Lee, Ji-Eun Kim, Yu-Jin Shin, Kyung-Tae Kim, Tae-Kwon Ryu, Ji-Sung Ryu, Jae-An Lee, Ig-Chun Eom, Pil-Je Kim, Kyung- Hee Choi and Byoung-Cheun Lee* National Institute of Environmental Research, Korea P3-049 Cytotoxicity of Platinum Nanoparticles in Raw 264.7 Cells Ta Thi Loan, Le Thanh Do and Hoon Yoo* Chosun University, Korea P3-050 In Vitro Cytotoxicity of CdSe/CdS and PbS Quantum Dots with Different Surface Coatings Jeong-Hee Kim, Hyo Jung Heo, Hye Rim Kim, Eun-Sook Choi, Su-Il In* and Eunjoo Kim* Daegu Gyeongbuk Institute of Science and Technology (DGIST), Korea P3-051 Skin Toxicity and Penetration of Silver Nanoparticles (AgNPs) in Vitro and in Vivo Dong Eun Jang, Byung-Mu Lee Sungkyunkwan University, Korea

P3-052 ~ 058 : Nephrotoxicity P3-052 Effect of Glutathione on Ecstasy-induced Nephrotoxicity Massumeh-Ahmadizadeh1, Fereshte Jeivad2 and Asma-Siavashpur3 1 Ahwaz Joundishapur University of Medical Sciences, Iran, 2 Tehran University of Medical Sciences, Iran, 3 Shiraz University of Medical Science, Iran P3-053 Maternal Transfer, Distribution and Reproductive Toxicity of Low-dose Melamine in Foetuses and Infants Ching Yan Chu and Chi Chiu Wang The Chinese University of Hong Kong, Hong Kong P3-054 Protective Effects of Pomegranate Seed Oil on Diazinon- induced Oxidative Damage in Rat Kidney Mohammad Taher Boroushaki and Delnia Arshadi Mashhad University of Medical Sciences, Iran The XIII International Congress POSTER / JULY 3 (WED) 101 of Toxicology

P3-055 L01 Attenuates Cisplatin-induced Cell Toxicity by Inhibition of Renal Organic Cation Transporter OCT2 Li Liping, Wang Kai, Song Feifeng, Sun Siyuan, Zhou Hui, Zeng Su and Jiang Huidi* Zhejiang University, China P3-056 To Evaluate the Protective Effect of Sildenaﬁ l in Experimental Nephrotoxicity in Rats Shubham Goyal1, Vaneeta Goyal2* and Nitin Verma1* 1 Baddi University of Emerging Science and Technology, India, 2 Himalyan institute of Pharmacy, India P3-057 Analysis of the Drinking Water in 89 Grounds in the Area of Higher Prevalence of Chronic Kidney Disease (CKD) of Etiology Unknown in Nicaragua Roberto Ruiz1, Edipcia Vilanova2, Aurora Aragon2, Luis Blanco2, Miguel Angel Sogorb3 and Eugenio Vilanova3* 1 University 'Miguel Hernandez', Spain, 2 Centro de Investigacion en Salud Trabajo y Ambiente (CISTA) Universidad Nacional Autonoma de Nicaragua (UNAN- Leon), Nicaragua, 3 Toxicologia Instituto de Bioingenieria Universidad Miguel Hernandez de Elche, Spain P3-058 Protective Effects of Quercetin against HgCl2-induced Nephrotoxicity in Sprague-dawley Rats Jeong Jun Kim1, Ye Ji Kim2, A Jin Won3, Yu Jin Shin3, Eun Young Park3, Eui Kyung Lee3, Zhou Lan3, Min Ju Kim4, Tae Hyung Kim3, Won Hee Kim5 and Hyung Sik Kim4 1 Groton School, USA, 2 The Hockaday School, USA, 3 Pusan National University, Korea, 4 Sungkyunkwan University, Korea, 5 Sehwa High School, Korea

P3-059 ~ 097 : Neurotoxicity P3-059 Microcystin-LR Slightly Affects Neurodevelopment in Rat Offspring Xiaobo Li*, Jue Zhou, Ran Liu, Yunhui Li, Lihong Yin and Jingjuan Ju Southeast University, China P3-060 Perinatal Exposure to Bisphenol a Affects Cortical Development and Induces Impulsive Behavior in Mice Wenting Ling1, Toshihiro Endo1, Wataru Miyazaki1, Eiki Kimura1, Ken-Ichiro Kubo2, Kazunori Nakajima2, Masaki Kakeyama1 and Chiharu Tohyama1* 1 The University of Tokyo, Japan, 2 Keio University, Japan P3-061 Manganese Exposure Induces Release of Alpha-synuclein and Promotes Exosome Mediated Cell to Cell Transmission of Synuclein Aggregates in Neurotoxicity Models Dilshan S Harischandra, Huajun Jin, Arthi Kanthasamy, Vellareddy Anantharam and Anumantha G Kanthasamy* Iowa State University, USA P3-062 Effect of Trientine Encapsulated Nanoparticles on Hippocampus Elevated Copper Concentration and Cognitive Impairments in Chronic Copper Intoxicated Wistar Rats Amit Pal*, Rama K Badyal, Rakesh K Vasishta and Rajendra Prasad PGIMER, Chandigarh, India P3-063 Study on Changes of Synapsin I in Acrylamide-induced Subacute Neurotoxicity in Rats Jingwei Xiao National Institute of Occupational Health and Poison Control, China CDC, China P3-064 Brain Endogenous Catechol Derivative Covalently Binds to Parkinson’s Disease-associated Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) and Alters Its Structure and Function Raluca V Contu1, Yaichiro Kotake1*, Shigeyoshi Samizo1, Takashi Toyama2, Yoshito Kumagai2 and Shigeru Ohta1 1Hiroshima University, Japan, 2 Tsukuba University, Japan P3-065 Effects of Prenatal Exposure to Buprenorphine on the Dopaminergic System of the Rat Offspring Yao-Chang Chiang and Ing-Kang Ho* Center for Drug Abuse and Addiction, China Medical University Hospital, Taiwan P3-066 Adolescent Toluene Exposure Enhances 5-HT2A Receptor-mediated Responses Hwei-Hsien Chen1* and Mei-Yi Lee2 1 National Health Research Institutes, Taiwan, 2 Tzu Chi University, Taiwan The XIII 102 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-067 Analysis of Late-onset Effects on CNS Induced by Transient GABA Signal Activation with Hypnotics During Brain Development Katsuhide Igarashi1, Kentaro Tanemura2, Yusuke Furukawa1, Maki Otsuka1, Noriko Moriyama1, Ken-Ichi Aisaki1, Satoshi Kitajima1 and Jun Kanno1* 1 National Institute of Health Sciences, Japan, 2 Tohoku University, Japan P3-068 Brain Metabolic Disorders Induced by a Convulsive Dose of Soman. In Vivo Study using Chemical Shift Imaging NMR Spectroscopy in Mice Guy Testylier1*, Vasile Stupar2, Florence Fauvelle1, Chantal Remy2, Helene Ratiney3 and Frederic Dorandeu1 1 IRBA - Grenoble, France, 2 INSERM - Grenoble Institut des Neurosciences, France P3-069 Role of l-thyroxin in Counteracting Rotenone Induced Neurotoxicity in Rats Mohamed M Elgamal1, Mohamed Salama1*, Aya Elgamal2*, Basem Helmy2*, Amr Reda2, Amr Ellaithy2, Dina Tantawy1, Mie Mohamed1, Hussein Sheashaa1 and Mohamed Sobh3 1 Mansoura Medical School, Egypt, 2 Mansoura Experimental Research Center, Egypt, 3 Urology & Nephrology Center, Mansoura Experimental Research Center, Mansoura Medical School, Egypt P3-070 In Vitro Long-term Exposure to Perfl uorooctane Sulfonate (PFOS) Leads to Decrease in GluR2 Protein Yumi Tsuyama, Chihiro Sugiyama, Seigo Sanoh, Yaichiro Kotake* and Shigeru Ohta Hiroshima University, Japan P3-071 Effects of Different Levels of Manganese Exposure on Learning and Memory in Neonate Rats Xiaodan Yu* XinHua Hospital affi liated to Shanghai Jiaotong University School of Medicine, China P3-072 Mechanism of Manganese-induced Repression on Excitatory Amino Acid Transporter 1 Eunsook Y Lee1*, Ashley North1, Pratap Karki1, Anton Webb1, Deok-Soo Son1 and Michael Aschner2 1 Meharry Medical College, USA, 2 Vanderbilt University, USA P3-073 Exposure to Bisphenol A during Gestation Alters Neuronal Morphology in the Hippocampus of Mouse Offspring Eiki Kimura, Wataru Miyazaki, Chieri Matsuyoshi, Masaki Kakeyama and Chiharu Tohyama* The University of Tokyo, Japan P3-074 Neurobehavioral Assessment in Mice Following Prenatal Exposures to Domoic Acid Following Repeated Oral Exposures Motohiro Shiotani*, Toby B Cole, Sungwoo Hong, Ju Young Park, William C Griffi th, Thomas M Burbacher, Lucio G Costa and Elaine M Faustman* University of Washington, USA P3-075 Elevation of Oxidatively Modifi ed Proteins in Nervous System Induced by 2,5-Hexanedione Treatment and Its Implications in Neurotoxicity Xiulan Zhao1, Qingshan Wang2, Qinghua Wang1, Hua Yuan1, Cuili Zhang1, Tao Zeng1 and Keqin Xie1* 1 Institute of Toxicology School of Public Health Shandong University, China, 2 National Institute of Environmental Health Sciences National Institutes of Health, USA P3-076 Low Concentration of Parkinson’s Disease-related Neurotoxin MPP+ Inhibits Autophagy Masatsugu Miyara, Yaichiro Kotake* and Shigeru Ohta Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan P3-077 Alternations of Pyrrole Adducts in Urine and Serum of Rats Induced by 2,5-HD Exposure Hongyin Yin, Ying Guo, Xiulan Zhao and Keqin Xie* Institute of Toxicology School of Public Health Shandong University, China P3-078 Exposure to Lead and Manganese Exacerbates the Activity of Brain Antioxidant Enzymes and Motor Behavior in Rats Chand D Basha*, Kavitha V Ram and Rajarami G Reddy Sri Venkateswara University, India P3-079 Effects of Nano-titanium Dioxide on Cortex Tissue and Its Level of Oxidative Stress in Rats Guozhen Li, Wenbin Wang, Fengmei Zhang, Sufang Yu, Jiliang Si and Jie Li* Shandong University, China The XIII International Congress POSTER / JULY 3 (WED) 103 of Toxicology

P3-080 2,4-Dichlorophenoxyacetic Acid-induced Neuronal Damage in Different Brain Parts of Rat Mohammad F Siddiqui*, Anjum Ara, Shamim J Rizvi and M M Hossain Aligarh Muslim University, India P3-081 Organophosphate Impacts on Human Neural Progenitor Cells: Effects on Epigenetics and Neuronal Proliferation and Differentiation Hee Yeon Kim*, Sungwoo Hong, Ju Young Park and Elaine M Faustman* Dept. of Environmental and Occupational Health Sciences, University of Washington, USA P3-082 Neuroprotective Effects of Protein Kinase a Inhibitor on Amyloid β-induced Memory Deﬁ cit Mohammad-Sharifzadeh1*, Elham-Amini1, Mahshad-Sharifzadeh2, Fariba-Khodagholi3 and Borna-Payandehmehr1 1 Tehran University of Medical Sciences, Iran, 2 Rabbani Educational Center, Iran, 3 Shahid Beheshti University of Medical Sciences (SUMS), Iran P3-083 Impaired Autophagy in Tri-Ortho-Cresyl Phosphate- Induced Delayed Neuropathy Fuyong Song and Keqin Xie* Shandong University, China P3-084 Nitrate (NO3-) and Nitrite (NO2-) Perturb the Activity of Dopaminergic Neuron during Early Development of Zebraﬁ sh (Danio Rerio) Meshkatul Jannat and Mitsuyo Kishida* Kumamoto University, Japan P3-085 Brain Metabolic Disorders Induced by a Convulsive Dose of Soman. In Vivo Study using Chemical Shift Imaging NMR Spectroscopy in Mice Guy Testylier IRBA, France P3-086 The Effects of Repeated Pre-exposure to Psychoactive Substances in the Abuse Potential of the NMDA Receptor Antagonist-benzodiazepine Combination, Zoletil® Jae Hoon Cheong Sahmyook University, Korea P3-087 Altered Distribution of Total IgG and its Isotypes in Serum and Brain of Autistic BTBR T+tf/J Mice Compared with Control FVB Mice So Nam Kim1, So Ryeon Hwang2, Ji Youn Kim2, Hyoung Ah Kim3 and Yong Heo2* 1 Korea Research Institute of BioScience & Biotechnology, Korea, 2 Catholic University of Daegu, Korea, 3 The Catholic University of Korea, Korea P3-088 Effects of Brain 5-HT levels and Plasma MMP-9 Activity on Disease Severity of Experimental Autoimmune Encephalomyelitis in High Fat Diet Induced Obese Mice Mahbub Hasan1, Ji- Eun Seo1, Min- Jung Kang2, Byung- Hwa Jung2, Suk Woo Nam3, Won Sang Park3, Ho- Youn Kim3 and Oh- Seung Kwon1* 1 Doping Control Center, KIST and Biomolecular Science, UST, Korea, 2 Molecular Recognition Research Center, KIST and Biomolecular Science, UST, Korea, 3 The Catholic University, Korea P3-089 Mechanisms of Blood-brain Barrier Disruption in Experimental Autoimmune Encephalomyelitis of Aged Mice Ji- Eun Seo1, Mahbub Hasan1, Min- Jung Kang2, Byung- Hwa Jung2, Suk Woo Nam3, Won Sang Park3, Ho- Youn Kim3 and Oh- Seung Kwon1* 1 Doping Control Center, KIST and Biomolecular Science, UST, Korea, 2 Molecular Recognition Research Center, KIST and Biomolecular Science, UST, Korea, 3 The Catholic University, Korea P3-090 Fucoidan Attenuates 6-Hydroxydopmaine-induced Neurotoxicity in SH-SY5Y Cells Myung-Bok Wie*, Myung-Hwan Kim, Myung-Sang Kwon and Hyoung-Chun Kim Kangwon National University, Korea P3-091 Neurobehavioral Effects of Atypical Antipsychotics using a Functional Observational Battery in Rats Joung-Wook Seo, Sun Young Kim, Sung-Ae Hyun, Ji Yoon Jo, Jeong-Woo Lee, Sun-Taek Leem, Gyu-Kap Choi, Hee-Kyung Hong, Sun-Hwa Chon and Eun Ju Jeong* Korea Institute Of Toxicology, Korea The XIII 104 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-092 Inhibitory Effect of Genistein against Inﬂ ammation and Amyloid Deposition in Brains of ApoE-/- Mice Fed a High-Fat Diet Young Hye Kwon*, Youn-Jin Park and Sookyoung Jeon Seoul National University, Korea P3-093 The Relationships between Lead and Hematological Parameters, Clinical Symptoms, and Mood and Memory Disorders in Automobile Repair Shop Workers Ali Akbar Malekirad1, Kobra Rahzani2*, Mahtab Mirzaee2 and Mohammad Abdollahi3 1 Payame Noor University, Iran, 2 Arak University of Medical science, Iran, 3 Tehran University of Medical Science, Iran P3-094 Tracing Pesticide Developmental Neurotoxicity from its Very Beginning --- a Hypothesis of eNSC Division Balance Disorder Xiaoping Chen Zhejiang University of Technology, China P3-095 Lead-exposure Modulates the Expression of Divalent Metal Transporter-1 and Ferroportin-1 in the Rat Brain and PC12 Cell Fankun Zhou, Ying Chen, Yanshu Li, Huan Jiao, Gaochun Zhu, Chang Feng, Guihua Du, Linfu Guan, Zhiping Wang and Guangqin Fan* School of Public Health, Nanchang University, China P3-096 The Effects of Long-term Exposure to Lead on Neurodegenerative Disease in Rats Yanshu Li, Ying Chen, Huan Jiao, Chang Feng, Gaochun Zhu, Fankun Zhou, Guihua Du, Linfu Guan, Zhiping Wang and Guangqin Fan* School of Public Health, Nanchang University, China P3-097 Lifting a Clinical Hold for Nonclinical Seizure Liabilities: Lessons Learned from Interactions with Regulators Simon Authier1, Mylene Pouliot2, Eric Troncy3 and Roy Forster4 1 CIToxLAB, University of Montreal, Canada, 2 CIToxLAB, Canada, 3 University of Montreal, Canada, 4 CIToxLAB, France

P3-098 ~ 106 : Omics in Toxicology P3-098 Identifi cation and Verifi cation of Manganese-related Differential Proteins in Choroid Plexus Hai-Ming Jing1, Yi-Wen Dong1, Chao-Ying Zhao1, Ling Ma1, Zhuang-Sheng Tan1, Zhang Tuo2, Xin-Yue Zhang2, Fan Yang2, Shan Gao1, Guo-Jun Li1* and Kai-Hua Wei2* 1 Beijing Centers for Disease Control and Prevention and Capital Medical University, China, 2 Beijing Proteome Research Center, China P3-099 Software-aided Processing of DNA Adductomics Data Obtained by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry Robert A Kanaly1*, Allyn H Maeda1, Natsuko Hamamura2 and Ruggero Micheletto1 1 Yokohama City University, Japan, 2 Ehime University, Japan P3-100 Gene Expression Profi ling in Male Mouse Livers Exposed to Acrylamide in Drinking Water Nan Mei, Mugimane G Manjanatha and Lei Guo FDA/NCTR, USA P3-101 Basic Factors that Infl uence the Rat Urinary Proteome Takayoshi Suzuki*, Suresh Thiruppathi, Tadashi Oshizawa, Keiko Maekawa, Yoji Sato and Yoshiro Saito National Institute of Health Sciences, Japan P3-102 The Comparisons of Toxicogenomic Responses in Zebrafi sh (Danio Rerio) Exposed to Different Sized AgNPs: the Impact of Size on Global Gene Expression Profi les June-Woo Park1*, Jinjong Bong2, Woo-Keun Kim1, Yongju Lee1 and Sung-Kyu Lee1 1 Korea Institute of Toxicology, Korea, 2 Nexbio, Korea P3-103 Investigation of Gene Expression Profi ling Induced by Polyhexamethylene Guanidine Hydrochloride (PHMG) in Human Cell Lines Ha-Na Jung, Tamanna Zerin, Biswajit Podder, Sae-Yong Hong, Ho-Yeon Song* and Yong-Sik Kim* Soochunhyang University, Korea P3-104 Liver Proteomics of Cynomolgus Monkeys (Macaca Fascicularis) Experimentally Exposed to Sodium Arsenite Soohee Kim1, Seung Heon Lee1, Seung Woo Lee1, Sohyeon Jeong1, Jung-Duck Park2 and Doug-Young Ryu1* 1 Seoul National University, Korea, 2 Chung-Ang University, Korea The XIII International Congress POSTER / JULY 3 (WED) 105 of Toxicology

P3-105 An Integrative Metabonomic Reconition Study on Urine, Plasma and Bone Marrow Cell of Mice with Benzene Exposure Rongli Sun, Juan Zhang, Lihong Yin and Yuepu Pu* Southeast University, China P3-106 Phosphoproteome of Daphnia Pulex Oh Kwang Kwon1, Ju Hee Sim1, Ki Na Yun2, Jin Young Kim2 and Sangkyu Lee1* 1 Kyungpook National University, Korea, 2 Mass Spectrometry Research Center, Korea Basic Science Institute, Korea

P3-107 ~ 109 : Others P3-107 Knowlegde is Level Students about using Pharmacology Toxicology Elly Usman IKAFI, Indonesia P3-108 RORα Decreases Oxidative Stress through the Activation of Anti-oxidant Enzymes and Thereby Attenuates Progression of Nonalcoholic Steatohepatitis Yong-Hyun Han, Eun-Jin Kim, Kyu-Seo Kim, Hyeon-Ji Kim, Suckchang Hong, Hyeong-Guen Park and Mi-Ock Lee* Seoul National University, Korea P3-109 Metastasis Associated Protein 1 Regulates Transcription of ERα Interacting with IFI16 Min-Ho Lee, Huun-Jin Kang, Sung-Hae Kim and Mi-Ock Lee* Seoul National University, Korea

P3-110 ~ 135 : Oxidative Stress and Redox Toxicity P3-110 Application of RNA Interference in Study of Activation of Benzo(a)pyrene Mediated by 5-lipoxygenase and DNA Damage in Human Bronchial Epithelial Cells Jing Wang1, Yun Huang2, Yue Wu2 and Jian`an Hu2* 1 Shanxi Province Center for Disease Control and Prevention, China, 2 Central South University, China P3-111 γ Radiation Induced Activation of Nrf2-regulated Antioxidant Enzymes: Protective Effect of a Multiple Antioxidant Xin Wang and Chunxu Hai* Fourth Military Medical University, China P3-112 Advanced Stent for the Regulation of Reactive Oxygen Species (ROS) Byeongtaek Oh and Chi H. Lee* University of Missouri, USA P3-113 Oxidative Stress and Liver Biochemical Alterations in Rats Exposed to Hexachlorobenzene and the Protective Effect of Alpha-tocopherol Hela Chalouati1*, Laurence Gamet-Payrastre2 and Mohamed Moncef Ben Saad1 1 Faculty of Sciences of Tunis, Tunisia, 2 UMR 1331, TOXALIM, National Institute of Agronomic Research (INRA) Toulouse, France P3-114 GSH-mediated S-Transarylation Regulates Covalent Modiﬁ cation of Keap1 by tert-Butylbenzoquinone Yumi Abiko, Takashi Miura, Phuc H Bui, Yasuhiro Shinkai and Yoshito Kumagai* University of Tsukuba, Japan P3-115 The Protective Effect of Palm Oil Tocotrienol Rich Fraction in Preventing Apoptotic and Oxidative Damage in Rat Testis Induced by Fenitrothion Siti Balkis Budin*, Izatus Shima Taib, Ahmad Rohi Ghazali, Putri Ayu Jayusman and Jamaludin Mohamed Universiti Kebangsaan Malaysia, Malaysia P3-116 Oxidative DNA Damage of Peripheral Blood Polymorphonuclear Leukocytes, Selectively Induced by Chronic Arsenic Exposure, is associated with Extent of Arsenic-related Skin Lesions Qiu-Ling Pei1*, Ning Ma2, Jing Zhang1, Wenchao Xu1, Yong Li1, Zhifeng Ma1, Yunyun Li1, Fengjie Tian1, Wenping Zhang1, Jinjun Mu1, Yuanfei Li1, Dongxing Wang1, Haifang Liu1, Mimi Yang1, Caifeng Ma1 and Fen Yun1 1 Shanxi Medical University, China, 2 Suzuka University of Medical Science, Japan The XIII 106 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-117 Regulatory Mechanism of Neointimal Formation after Vascular Injury by Redox-sensitive Transcription Factor Nrf2 Takashi Ashino1*, Masayuki Yamamoto2, Takemi Yoshida1 and Satoshi Numazawa1 1 Showa University School of Pharmacy, Japan, 2 Tohoku University Graduate School of Medicine, Japan P3-118 Benefi cial Effect of Hibiscus sabdariffa UKMR-2 in Hormonal and Histological Changes in Streptozotocin Induced Diabetes Rats Jamaludin Mohamed1, Muhd Hanis Md Idris1, Siti Balkis Budin1, Mariati Abd Rahman1 and Mohamad Osman2 1 Universiti Kebangsaan Malaysia, Malaysia, 2 Universiti Teknologi MARA, Malaysia P3-119 Evaluation of Autistic Children in Terms of Blood Antioxidant Enzymes Levels Ahmet Sayal1*, Ozgur Yorbik2, Zeliha Kayaaltı3, Yasemin Kartal3 and Cemal Akay4 1 Gulhane Military Medical Academy, Turkey, 2GATA Child and Adolescent Psychiatry Department, Turkey, 3 Ankara University Institute of Forensic Science, Turkey, 4 GATA Toxicology Department, Turkey P3-120 The Cathepsin B Inhibitor, z-FA-CMK, Induces Oxidative Stress Toxicity in Human Leukemic T Cells Yee K Liow Monash University, Malaysia P3-121 Effects of Spray Drying on Oxidation of Dairy Protein and Redox State of Mice Ling Mo, Yong Hui Shi and Guo Wei Le* Jiangnan University, China P3-122 Effects of Beta-glucan on Streptozotocin Induced Diabetic Rats Mujgan Cevik and Tulay Bakırel* Istanbul University Faculty of Veterinary Medicine Department of Pharmacology and Toxicology, Turkey P3-123 Mechanisms of Acute Hematotoxicity by Hydroxylamine Sulfate Georgiy M Prodanchuk L.I.Medved`s Research Center of Toxicology MH Ukraine, Ukraine P3-124 Catalytic Activity of Superoxide Dismutase, Catalase and Glutathione Peroxidase in Plasma and Eritrocites of Rats treated with Ochratoxin A, Citrinin and Resveratrol Maja Peraica*, Dubravka Rasic, Alica Pizent, Blanka Tariba and Tanja Zivkovic Institute for Medical Research and Occupational Health, Croatia P3-125 Fyn Inhibition Protects Hepatocyte Mitochondria from Oxidative Injury Ja Hyun Koo and Sang Geon Kim* College of Pharmacy, Seoul National University, Korea P3-126 Antioxidative and Epigenetic Function of Blueberry (Vaccinium spp.) Minju Kim, Mihi Yang* and Hyun Kyung Na Sookmyung Women’s University, Korea P3-127 The Role of Sestrin2 on TLRs-induced Proinfl ammatory Signaling Yang Ji Hye and Sung Hwan Ki* Chosun University, Korea P3-128 Mitochondrial ROS Induces Airway Infl ammation and Hyperresponsiveness in Bronchial Asthma So Ri Kim, Dong Im Kim, Mi Ran Kang and Yong Chul Lee* Chonbuk National University Medical School, Korea P3-129 Effects of Fermented Rhynchosia Nulubilis on Antioxidative Activity and Lipid Metabolism Jeonghyeon Son and Baejin Ha* College of Medical Life Science, Silla University, Korea P3-130 Effects of Engraulis Japonicus Powder-added Tomato on Menopausal Osteoporosis Jeonghyeon Son and Baejin Ha* Silla University, Korea P3-131 Nrf2 Dependent Proteasomal Pathway in the Endoplasmic Reticulum Stress Response in Pancreatic β-cells Ingeun Ryoo1, Sanghwan Lee2 and Mi-Kyoung Kwak1* 1 The Catholic University of Korea, Korea, 2 Yeungnam University, Kore The XIII International Congress POSTER / JULY 3 (WED) 107 of Toxicology

P3-132 Aldo-keto Reductases as Potential NRF2-target Marker Genes in Human Cells Kyeong-Ah Jung, Bo-Hyun Choi and Mi-Kyoung Kwak* The Catholic University of Korea, Korea

P3-133 The Comparison of Psychological State, Oxidative Stress and DNA Damage After and Before using Lemon Balm and Cinnamon in Paint Workers Ali Akbar Malekirad1, Mohammad Abdollahi1 and Mehdi Kiani2* 1 Tehran University of Medical Science, Iran, 2 Payame Noor University, Iran P3-134 PM2.5 Induces Nrf2-mediated Defense Mechanisms against Oxidative Stress by Activating PIK3/AKT Signaling Pathway in Human Lung Alveolar Epithelial A549 Cells Wenjun Ding, Xiaobei Deng, Wei Rui and Fang Zhang University of Chinese Academy of Sciences, China P3-135 2-(2-nitrovinyl)furan Induces Redox Imbalance of Male Rats’ Liver and Kidney Taofeek O Ajiboye1*, Kazeem A Alabi2, Fuad A Ariyo2, Abdulwasiu O Adeleye2, Ganiyat A Iliasu2 and Folakemi A Abdussalam2 1 Al-Hikmah University, Nigeria, 2 Fountain University, Nigeria

P3-136 ~ 157 : Pesticides P3-136 In Vitro Effect of N-acetylcysteine on Hepatocyte Injury Caused by Dichlorodiphenyltrichloroethane (DDT) and Its Metabolites Jacob J Van Tonder1*, Mary Gulumian2, Allan D Cromarty1 and Vanessa Steenkamp1 1 University of Pretoria, South Africa, 2 National Institute of Occupational Health, South Africa P3-137 A Systematic Review on the Nerve-muscle Electrophysiology in Human Organophosphorus Pesticide Exposure Somayyeh Karami-Mohajeri1, Shekoufeh Nikfar2* and Mohammad Abdollahi1 1 Tehran University of Medical Sciences, Iran, 2 Tehran University of Medical Sciences and FDO, Ministry of Health, Iran P3-138 Biochemical and Molecular Mechanisms of Muscular Mitochondrial Dysfunction Following Exposure to Malathion Somayyeh Karami-Mohajeri, Mohammad-Reza Hadian, Shamileh Fouladdel, Ebrahim Azizi*, Mohammah-Hossein Ghahramani, Rohollah Hosseini and Mohammad Abdollahi* Tehran University of Medical Sciences (TUMS), Iran P3-139 Teratological and Histopathological Studies of a Deltamethrin Containing Insecticide Formulation in Chicken Embryo Nitu Bhaskar*, Lata Shahani and Pradeep Bhatnagar The IIS University, India P3-140 Brush Border Enzymes and Redox Status in Small Intestine of Rats are Affected by Organophosphorus Insecticides Vismaya Vismaya and Rajini P Sharada* Central Food Technological Research Institute, India P3-141 Approximate Determination of Organochlorine Residues in Simplisia Annisa Sukmasari and Amalia E Hidayat University of Indonesia, Indonesia P3-142 Metabolic Switch in Energetic Metabolism of Colon Cancer Cells by Environmental Pollutants Clementine Perriere*, Martine Collinet, Alexandra Lopes-Costa, Sylvie Bortoli, Xavier Coumoul, Robert Barouki and Chantal Benelli INSERM UMRS-747 Paris Descartes University, France P3-143 Improvement of Model of Pesticides Risk Assessment for Operators Irina V Bereznyak* Federal Scientiﬁ c Center for Hygiene Named after F. Erisman, Russia P3-144 New Formulation of Paraquat with Lysine Acetylsalicylate with Low Mammalian Toxicity and Maintained Herbicidal Activity Maria T Baltazar, Ricardo J Dinis-Oliveira, Lucia Guilhermino, Jose A Duarte, Maria De Lourdes Bastos and Felix Carvalho University of Porto, Portugal The XIII 108 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-145 Non Enzymatic Antioxidants and Acetylcholinesterase Activity in Farmers Exposed to Organophosphate Pesticides in Nigeria Olubayo M Akinosun1* and Tolulope Adewole2 1 University of Ibadan, Nigeria, 2 University College Hospital, Nigeria P3-146 Initial and New POPs Pesticides: Soil Contamination in Armenia Anahit Aleksandryan1 and Vahagn Khachatryan2 1 Ministry of Nature Protection of the Republic of Armenia, Armenia, 2 “EcoTox” Environment and Health NGO, Armenia P3-147 Risk Assessment of Chlorantraniliprole Use in Ukraine Mykola Prodanchuk, Igor Leposhkin, Nadiia Nedopytanska, Piter Zhminko, Alex Kravchuk and Alla Grynko L.I.Medved`s Research Center of Toxicology MH Ukraine, Ukraine P3-148 Morphological Pattern of the Hepatopancreas of Carp Reared Close to a Pesticide Dump before its Closure and Nine Years Later Jozef Szarek1*, Izabella Babinska1, Katarzyna Sawicka-Kapusta2, Janusz Zakrzewski1, Krystyna Dublan1 and Marta Zakrzewska2 1 University of Warmia and Mazury, Poland, 2 Jagiellonian University, Poland P3-149 A549 Cellular Toxicity of Acetochlor via Generation of Intracellular Reactive Oxygen Species and Extracellular Signal-regulated Kinase-mediated Apoptosis Tamanna Zerin, Ho-Yeon Song* and Yong-Sik Kim* Soonchunhyang University, Korea P3-150 Effi cacy of Pinus Densifl ora Hydrodistillate as an Alternative for Currently used Synthetic Larvicides Dong Chan Lee1* and Young-Joon Ahn2 1 Hankuk Academy of Foreign Studies, Korea, 2 Seoul National University, Korea P3-151 Acute Pesticide Poisoning among Children in South Korea: Findings from National Health Insurance Claims Data, 2006-2009 Won Jin Lee*, Yousun Ko and Eun Shil Cha Korea University, College of Medicine, Korea P3-152 Mortality from and Incidence of Pesticide Poisoning in South Korea: Findings from National Death and Health Utilization Data between 2006 and 2010 Eun Shil Cha1, Young Ho Khang2 and Won Jin Lee1* 1 Korea University, Korea, 2 University of Ulsan, Korea P3-153 Evaluation for Residual Pesticides of Commercial Agricultural Products using LC-MS/MS in Korea Hwa-Mi Lee, Soojung Hu, Hyun-Sook Lee, Seung Young Park, Nam-Sun Kim, Yong Woo Shin, Keun Hwa Choi, Mi-Jung Noh, Sung Il Kim and Dae Hyun Cho* Gyeongin Regional Food and Drug Administration, Korea P3-154 Analysis of the Pesticide Flufenoxuron in Postmortem Specimens using Liquid Chromatography with Tandem Mass Spectrometry in a Fatal Case Jongsook Rhee*, Juseon Lee, Sungmin Moon, Hyesun Yum, Hyunhee Kam, Sangki Lee and Yonghoon Park National Forensic Service (NFS), Korea P3-155 Chronic Effects of ‘Resmethrin’ on Protein Metabolism of the Indian Bull Frog Rana Tigerina (Daud) Sreenath Pillai Shiats University, India P3-156 Toxicodynamics and Toxicokinetics of Triazine Herbicide in Nanoform Valery N Rakitskiy Federal Scientifi c Center of Hygiene named after F.Erisman, Russia P3-157 Impact of Organochlorine Pesticide on Epididymis Structure and Function of Male Rat Nisha Jain Goerment p G College Dausa Jaipur India, India The XIII International Congress POSTER / JULY 3 (WED) 109 of Toxicology

P3-158 ~ 161 : Radiation P3-158 EMP Induced Activation of P38 MAPK Pathway and Alteration of BRB Xuejun Xie Fourth Military Medical University, China P3-159 Whole Brain Irradiation Induces Pro-oxidative and Pro-inﬂ ammatory Pathways in Brain Yong W Lee1*, Hyung J Cho1 and William E Sonntag2 1 Virginia Tech, USA, 2 University of Oklahoma Health Sciences Center, USA P3-160 Experimental Animal Model using Irradiation for Evaluation of Protectors for Haematopoietic Damage and Neurodegeneration Beom Su Jang, Jung Ae Kang, You-Ree Nam and Sang Hyun Park* Korea Atomic Energy Research Institute, Korea P3-161 Protective Activity of Novel Resveratrol Analogue, HS-1793 against DNA Damage in 137Cs Irradiated CHO-K1 Cells Min Ho Jeong1, Kwangmo Yang2, Dong Hyeok Jeong2, Chang Geun Lee2, Su Jung Oh2, Soo Kyung Jeong2, Young Rae Jo2 and Wol Soon Jo2* 1 Dong-A University College of Medicine, Korea, 2 Dong Nam Institute of Radiological & Medical Sciences, Korea

P3-162 ~ 168 : Receptor Mediated Toxicity P3-162 Identifi cation and Functional Characterization of a Novel Chicken Aryl Hydrocarbon Receptor Isoform, 2nd AHR1 Jin-Seon Lee1, Kohei Iwabuchi1, Koji Nomaru1, Nobumasa Nagahama1, Eun-Young Kim2 and Hisato Iwata1* 1 Ehime University, Japan, 2 KyungHee University, Korea P3-163 Effects of Perfl uoroalkyl Acids on the Function of the Nuclear Receptors in Vitro Manhai Long, Lisbeth S Kjeldsen, Mandana Ghisari and Eva Cecilie Bonefeld-Jorgensen Aarhus University, Denmark P3-164 Polyethylene Glycol Modifi ed Phosphotriesterase: Biochemical Characterization Zuzana Krenkova Univerzity of Defence, Czech P3-165 Nuclear Hormone Receptor-mediated Toxicity John P Vanden Heuvel State Universityand INDIGO Biosciences, USA P3-166 Effects of Aryl Hydrocarbon Receptor and Transcriptional Co-factor(s) on Dioxin-induced Transactivation in MRL/lpr and C3H/lpr Mouse Strains See-Wun Cho1, Ken-Ichi Suzuki 2, Yoshiaki Miura 2, Hisato Iwata 2, Tatsuhiko Miyazaki 2, Masato Nose2 and Eun-Young Kim1* 1 Kyung Hee University, Korea, 2 Ehime University, Japan P3-167 Isoform-specifi c Responses of Aryl Hydrocarbon Receptor to Dioxins in Red Seabream (Pagrus Major) Su-Min Bak1, Midori Iida2, Masashi Hirano2, Hisato Iwata2 and Eun-Young Kim1* 1 Kyung Hee University, Korea, 2 Ehime University, Japan P3-168 Peroxisome Proliferator-activated Receptors (PPARs): Key Regulators of Metabolic Diseases in Therapeutic and Toxicological Perspectives Min Ju Kim, Hyung Sik Kim and Byung-Mu Lee* Sungkyunkwan University, Korea

P3-169 ~ 201 : Risk Assessment P3-169 Children Exposure to Bisphenol a from Baby Bottles in Cameroon and Nigeria: A ﬁ eld Enquiry Guy B Pouokam1, Godwin A Chukwuebuka2, Chiara Frazzoli3, Orish E Orisakwe2 and Alberto Mantovani3 1 Education and Research Network, Cameroon, 2 Education and Research Network, Nigeria, 3 Education and Research Network, Italy The XIII 110 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-170 Risk Assessment Criteria Anahit Aleksandryan1, Tatiana Shashina2 and Natalya Skvortsova2 1 Ministry of Nature Protection of the Republic of Armenia, Armenia, 2 A.N. Sysin State Scientifi c Research Institute of Human Ecology and Environmental Hygiene, Russia P3-171 Studies on Acute Toxicity, Subchronic Toxicity and Genotoxicity of Plumeria Bin J Tan, Min Zhao, Ming J Huang, Yi R Chen and Fen X Yang* Guangdong Provincial Centre for Disease Control and Prevention, China P3-172 Eco-toxicity Assessment of Well Drilling Mud Disposal on Open Pit Site Jinglan Hong Shandong University, China P3-173 Human Health Risk Assessment in Relation to Freshwater Pollution in El-saff and Atfeeh Cities, Giza Governorate, Egypt Hanaa M El-Khayat Theodor Bilharz Research Institute, Egypt P3-174 A Convenient Method to Detect Covalent Modifi cation of Protein Thiols by Environmental Electrophiles Takashi Toyama1, Toshiyuki Kaji1 and Yoshito Kumagai2 * 1 Tokyo University of Sciences, Japan, 2 University of Tsukuba, Japan P3-175 Assessment of Some Heavy Metals in Hair of Children from Iassy Area, Risk in Cancer Disease Carmen Hura INPH/CRPH Iasi, Romania P3-176 A Physiologically Based Pharmacokinetic (PBPK) Model Development for Aristolochic acid I and II (AAI and AAII) and Corresponding Metabolites, Aristolactams (ALs), in Rats Chimeddulam Dalaijamts, Kuen-Yuh Wu*, Hwa-Lung Yu and Ming-Tsai Wey National Taiwan University, Taiwan P3-177 Sampling Validation for Risk Assessment Nathalie Wesolek*, Dominique Parent-Massin and Alain-Claude Roudot Universite de Bretagne Occidentale Laboratoire d'evaluation du Risque Chimique Pour le Consommateur, France P3-178 Threshold of Toxicological Concern - Status and Future Direction Renjun Gao1*, Summer Shen1 and Heli M Hollnagel2 1 Dow Chemical China (investment) Company Limited, China, 2 Dow Europe GmbH, Switzerland P3-179 The Dimethylformamide (DMF) Exposures in Artifi cial Leather Factory Yu-Chuan Chuang, Yu-Fang Huang and Kuen-Yuh Wu* National Taiwan University, Taiwan P3-180 Probabilistic Assessment of Aggregate Health Risk for Dioxin in Taiwan Shu-Yu Liu and Kuen-Yuh Wu National Taiwan Unervisity, Taiwan P3-181 Risk Assessment of Taiwanese Residential Exposure to Bis(2-ethylhexyl)phthalate (DEHP): an Application of the CalTOX Multimedia Exposure Model Chi-Hsuan Chang and Kuen-Yuh Wu National Taiwan University, Taiwan P3-182 Methodology on the Risk Assessment of Biocidal Product Containing Several Active Substances or Substances of Concern Chloe De Lentdecker Anses - French Agency for Food, Environmental and Occupational Health Safety, France P3-183 Health Impact Assessment (HIA) as a Tool for the Environmental Licensing in the Brazilian Oil Industry Eduardo M Barbosa1, Martha Barata2 and Sandra S Hacon3 1 Petroleo Brasileiro SA - PETROBRAS, Brazil, 2 Oswaldo Cruz Foundation - FIOCRUZ/IOC, Brazil, 3 Oswaldo Cruz Foundation - FIOCRUZ/ENSP, Brazil The XIII International Congress POSTER / JULY 3 (WED) 111 of Toxicology

P3-184 Use of Proast Software to Assess Hepatotoxic Effect of Decabrominated Diphenyl ether in Subacutely Exposed Rats Marijana Curcic1*, Marijana Jevtic1, Katarina Jevtic1, Evica Antonijevic1, Slavica Vucinic2, Vesna Jacevic2, Vesna Matovic4 and Biljana Antonijevic1 1 University of Belgrade, Serbia, 2 National Poison Control Center, Military Medical Academy, Serbia P3-185 The WHO Chemical Risk Assessment Network - a Global Collaborative Approach to Human Health Risk Assessment Kathy Hughes1 and Carolyn Vickers2* 1 Health Canada, Canada, 2 World Health Organization, Switzerland P3-186 Proposed Testing Strategy and Evaluation of Classiﬁ cation on Germ Cell Mutagenicity Based on Test Results for New Chemical Substances Notiﬁ cation in China Sophie Li and Xunhe Ji* Huntsman, China P3-187 Risk Assessment of the Combined Exposure of Pregnant Women and 2-year Olds to Endocrine Disruptors Helle B Boyd DHI, Denmark P3-188 Risk Assessment and Hazards of Epichlorohydrin Hyeon-Yeong Kim and Jeong-Hee Han Korea Occupational Safety and Health Agency, Korea P3-189 Calculating Therapeutic Index for Korean Traditional Medicines on the Basis of ALD Sundong Lee* Sangji University, Korea P3-190 Mercury Bioaccommodation in Freshwater Fish and Fish Consumption Advisory : A Case Study in Lake An-dong, S. Korea Jinju Park1, Younghee Kim1*, Kijun Kim1, Eunhee Kim2, Seokmin Yu1 and Kwangseol Seok1 1 National Institue of Environmental Research, Korea, 2 Gwangju Institute of Science and Technology, Korea P3-191 A 4 Week Repeated Dermal Toxicity Study of Isopropyl Paraben, Isobutyl Paraben or the Mixture and Risk Assessment for Consumer Products Min Ji Kim1, Mi Young Ahn2, Hyung Sik Kim1 and Byung Mu Lee1* 1 Sungkyunkwan University, Korea, 2 National Academy of Agricultural Science, Korea P3-192 Regulatory and Risk Management System for Green Chemistry in Korea Seung Kyu Lee, Min Jung Kim, Hee-Kyung Bea and Hyeon-Soo Park* To21, Co.,Ltd., Korea P3-193 Effects of Cyanotoxin, Microcystin-LR on Embryonic Development of Oryzias Latipes Jungkon Kim, Jung-Kwan Seo*, Hyo-Jung Yoon, Taksoo Kim, Yu-Jin Shin, Areum Jo, Pil-Je Kim and Kyunghee Choi National Institute of Environmental Research, Korea P3-194 Risk Assessment and Management of Hazardous Chemicals in the Goods for Children in Korea Jun Young Chang1*, Jung Sub Lee1, Sun Kyoung Chung1, Seung Do Yu1, Kyounghee Choi1, Kun-Ho Park2 and In Seak Choi3 1 National Institute of Environmental Research, Korea, 2 Neo Environmental Business Co., Korea, 3 Korea Conformity Laboratories, Korea P3-195 Evaluation of Polycyclic Aromatic Hydrocarbon Contents and Risk Assessment for Fish and Meat Products in Korea Minji Kim and Han-Seung Shin Dongguk University, Korea P3-196 Risk Assessment of Volatile Organic Compounds (VOCs)(Benzene, Toluene, Ethylbenzene, and Xylene) for Consumer Products Seong Kwang Lim, Hyung Sik Kim and Byung-Mu Lee* Sungkyunkwan University, Korea The XIII 112 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-197 A Study on Human Risk Assessment of Endocrine-disrupting Chemicals Derived from Plastic Food Containers Du-Yeon Bang1, Minji Kyung2, Min Ji Kim2, Bu Young Jung2, Myung Chan Cho2, Seul Min Choi2, Young Woo Kim2, Seong Kwang Lim2, Duck Soo Lim2, A Jin Won1, Seung Jun Kwack3, Young Kwan Lee1, Hyung Sik Kim2* and Byung Mu Lee2* 1 Sungkyunkwan University, Korea, 2 Pusan National University, Korea, 3 Changwon National University, Korea P3-198 Human Monitoring of Exposure to Phthalate Esters in Korean Children and Adolescents and Risk Assessment Dong Hyun Kim, Dong Wook Kim, Hyung Sik Kim and Byung Mu Lee* Sungkyunkwan University, Korea P3-199 Evaluation of Polycyclic Aromatic Hydrocarbon Contents and Risk Assessment of Edible Oils in Korea Ju-Hyun Han and Han-Seung Shin Dongguk University, Korea P3-200 Risk Factors for Prostate cancer patients among Gezira State-Central of Sudan Fatima A Hamad, Dafaallahi O Abuidris and Fatima A Hamad* University of Gezira, Sudan P3-201 Substance Abuse of School's Students at Beniseuf Governorate Fadwa A Elrouby* Beni Seuf University, Egypt

P3-202 ~ 206 : Skin Toxicity P3-202 Skin Toxicity as a Criterion for Risk Assessment Anahit Aleksandryan1 and Artak Khachatryan2 1 Ministry of Nature Protection of the Republic of Armenia, Armenia, 2 Waste Research Center, Armenia P3-203 The Study of Dermal Cellular Toxic Effects by Air-liquid Exposure Model Cheng-Hang Lan1, Ze-Yao Huang1, Sheng-Huei Ho1, Te-Cheng Wu2 and Chiung-Yu Peng2 1 Chung Hwa University of Medical Technology, Taiwan, 2 Kaohsiung Medical University, Taiwan P3-204 T-2 Toxin Induced Cytokines Upregulation and Cell Death in Human Keratinocytes Mona Agrawal, A S B Bhaskar, G M Kannan and P V L Rao* Defence Reaserach and Development Establishment, India P3-205 Evaluation of Effects of Different Treatment in Loxocelism; Observations Based in Evidence Laura Borgel* and Melissa Schulthess* RITA-Chile, Chile P3-206 The Atopic Dermatitis-like Symptoms Induced By MC903 were Alleviated In JNK1 Knockout Mice Jinhwan Choi, Heejeung Kim, Hyong Joo Lee, Jiyoung Kim*, Ki Won Lee* and Jong Rhan Kim Seoul National University, Korea

P3-207 ~ 216 : Stem Cell Toxicology P3-207 Role of Connexin 32 in Hematopoiesis: Maintaining Mechanism of Quiescent Hematopoietic Stem Cells and Their Simultaneous Steady-state Proliferation Yoko Hirabayashi1*, Byung-Il Yoon2, Isao Tsuboi2, Jun Kanno1, James E Trosko4 and Tohru Inoue3 1 National Institute of Health Sciences, Japan, 2 Kangwon Natonal University, Korea, 3 Nihon University, Japan, 4 Michigan State University, USA P3-208 Mouse Bone Marrow Mesenchymal Stem Cells (BMSC) as a Predictive Model for in vitro Molecular Toxicity Santha Kumar Syama, N S Remya, B Leji, C S Reshma, C S Geetha, V Gayathri, H K Varma and P V Mohanan* Sree Chitra Tirunal Institute for Medical Sciences and Technology, India P3-209 Identiﬁ cation of Stage-speciﬁ c Gene Expression Signatures in Response to Retinoic Acid during the Neural Differentiation of Mouse Embryonic Stem Cells Hideko Sone1*, Hiromi Akanuma1, Reiko Nagano1, Tomokazu Fukuda2 and Seiichiroh Ohsako3 1 National Institute for Environmental Studies, Japan, 2 Tohoku University, Japan, 3 The University of Tokyo, Japan The XIII International Congress POSTER / JULY 3 (WED) 113 of Toxicology

P3-210 A Brief Review on the Studies of Stem Cell Toxicology Bilal C Liman University of Erciyes, Turkey P3-211 Low-dose Manganese Disrupted Neural Differentiation in Murine Embryonic Stem Cells Takao Tobe, Yuki Taniguchi, Yoshinori Okamoto, Eiji Matsuda, Hironori Iwai, Koji Ueda, Tatsuyuki Takada and Nakao Kojima* Meijo University, Japan P3-212 In vitro Myelotoxic Effects of Cypermethrin and Mancozeb on Human Cord Blood Progenitor Cells Rajesh Mandarapu and Prakhya B Murthy* International Institute of Biotechnology And Toxicology (IIBAT), India P3-213 Assessment of hERG Channel Function Using Human Stem Cell Derived Cardiomyocytes Jeffrey Irelan*, Xiaoyu Zhang, Wei Ouyang, Biao Xi, Xiaobo Wang, Xiao Xu and Yama Abassi ACEA Biosciences, Inc., USA P3-214 High Glucose Condition Induces Autophagy and Activation of Matrix Metalloproteinase Kyeong-A Kim and Ok-Nam Bae* Hanyang University, Korea P3-215 Phosphodiesterase 4D Inhibition Induces Cell Cycle Arrest and Neural Differentiation via cAMP/PKA Signaling in Primary Glioblastoma Multiforme: Therapeutic Implication for Glioblastoma Multiforme Tae Wook Kang1, Se-Ran Yang1, Soon Won Choi1, Kyung-Rok Yu1, Kang Ho Kim2, Do-Hyun Nam2 and Kyung-Sun Kang1* 1 Seoul National University, Korea, 2 Sungkyunkwan University, Korea P3-216 The Effects of Hedgehog on the RNA-binding Protein Msi1 in the Proliferation and Apoptosis of Mesenchymal Stem Cells In Sun Hong and Kyung-Sun Kang* Seoul National University, Korea

P3-217 ~ 225 : Systems Toxicology (Genomics, Proteomics, Metabolomics) P3-217 Systems Toxicology Assessment of the Effects of Repeated Cigarette Smoke Exposure on Human Respiratory Tract Tissue Cultures Carole Mathis, Radina Kostadinova, Sandra Wagner, Stefan Frentzel, Fabio Talamo, Nikolai Ivanov, Yang Xiang, Florian Martin, Alain Sewer, Manuel C Peitsch and Julia Hoeng Philip Morris Products S.A., Switzerland P3-218 In vitro Evaluation of the Biological Impact of Harmful and Potentially Harmful Constituents of Tobacco Smoke using a Systems Toxicology Approach Ignacio Gonzalez Suarez1, Carole Mathis1, Emmanuel Guedj1, Paul Walker2, Samantha Ellis2, Heather Woodhouse2, Remi Dulize1, Karine Baumer1, Darius Peric1, Sandra Wagner1, Florian Martin1, Nikolai V Ivanov1, Julia Hoeng1* and Manuel C Peitsch1 1Philip Morris International R&D, Philip Morris Products S.A., Switzerland, 2 Cyprotex, United Kingdom P3-219 28-Day Rat Inhalation Study - How Systems Toxicology Complements OECD Inhalation Studies Ulrike Kogel*, Walter Schlage, Florian Martin, Sam Ansari, Yang Xiang, Julia Hoeng and Manuel C Peitsch Philip Morris International R&D, Switzerland

P3-220 MWCNT Toxicity Pathway Analysis in C.elegans Carlos P Roca1*, Francesc Giralt1 and Jinhee Choi2 1 Universitat Rovira i Virgili, Spain, 2 University of Seoul, Korea P3-221 iTRAQ Protein Proﬁ le Analysis of Mouse Testis After Perﬂ uorooctanoate (PFOA) Exposure Hongxia Zhang Institute of Zoology, Chinese Academy of Sciences, China P3-222 Pesticides and Human Chronic Diseases; Evidences, Mechanisms and Perspectives Mohammad Abdollahi1 and Sara Mostafalou2* 1 Tehran University of Medical Sciences, Iran, 2 Tehran University of Medical Sciences and Iran National Science Foundation (INSF), Iran The XIII 114 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-223 Advancing Regulatory Science with Omic and Bioinformatics Roger Perkins US Food and Drug Administration, USA P3-224 Systems Toxicology in ApoE-/- Mice Demonstrates Smoking Cessation Beneﬁ ts for both Cardiovascular and Lung Disease-related Endpoints Julia Hoeng Philip Morris International R&D, Switzerland P3-225 Dinoﬂ agellate Genomics for Understanding Marine Environmental Problems Senjie Lin Xiamen University, China

P3-226 ~ 257 : Toxicity Testing P3-226 Confi rmation of MRC-5 or HeLa Cell Properties for Use as a Negative or Positive Control for Tumorigenicity Testing Ji-Young Kim, Shin-Woo Cha, Eun Ju Jeong, Wook-Joon Yu and Kyoung-Sik Moon Korea Institute of Toxicology, Korea P3-227 The Bull Spermatozoa Video Image Citotoxicity Test Andrey P Eskov, Anatoly E Sokolov and Oleg E Zaitsev Firm 'BMK-INVEST', ZAO, Russia P3-228 The Sensitivity of Young Nymphal Stage of Trialeurodes Vaporariorum to Imidacloprid, Acetamiprid and Entomopathogenic Fungus, Lecanicillium longisporum in Laboratory Conditions Omid Panahi, Azadeh Loni, Mohammad Dalvand, Nahid Mohammadbeigi, Alireza Ansari and Maryam Bajoulvand Payame Noor University, Iran P3-229 In Vitro and in Ovo Inhibition of Type-A Avian Infl uenza Virus by Xanthone Derivates from Garcinia Mangostana Linn Fruit Rind Amar Muslim, Sarah Fitriani, Sherryn S Albanny and Fajar I Sitanggang Bogor Agricultural University, Indonesia P3-230 General Principles of Chemical Selection for in Vivo Validation Studies Takeshi Morita1, Hajime Kojima1 and Makoto Hayashi2 1 National Institute of Health Sciences, Japan, 2Biosafety Research Center, Japan P3-231 Temtox: a Novel Chemical Toxicity Test Revealing an Epithelial-to-Mesenchymal Transition Sylvia Sanquer*, Laurence Herry, Celine Tomkiewivz and Robert Barouki INSERM UMR-S 747, Universite Paris Descartes, France P3-232 Toxicity Study of “Culantro Leaves” on Hematology, Biochemistry And Kidney Histopathology in Mice Kanittha Janwitthayanuchit1, Piengchai Kupradinun2, Anudep Rungsipipat3, Aikkarach Kettawan1 and Chaniphun Butryee1* 1 Institute of Nutrition, Mahidol University, Thailand, 2 National Cancer Institute, Thailand, 3 Chulalongkorn University, Thailand P3-233 Regulatory Science for the Safety Evaluation in Non-clinical Research and Development in Japan Shunji Nomura1* and Ikuo Horii2 1 Pfi zer Japan Inc., Japan, 2 Pfi zer Inc., USA P3-234 PCNA Index, iNOS and COX-2 Expression in Mouse Colon Treated with Traditional Cooked of Moringa Pod Sirintip Budda1, Chaniphun Butryee1*, Siriporn Tuntipopipat, Anudep Rungsipipat2, Supradit Wangnaithum2, Jeong-Sang Lee3 and Piengchai Kupradinun1 1 Institute of Nutrition, Mahidol University, Thailand, 2 Chulalongkorn University, Thailand, 3 Yale University School of Medicine, USA P3-235 Gene Therapy Medicinal Products: Toxicological Challenges Anna Lanzoni*, Chiara Piubelli, Elena Vicentini and Sergio Raimondo Aptuit Centre for Drug Discovery & Development, Italy The XIII International Congress POSTER / JULY 3 (WED) 115 of Toxicology

P3-236 CO-Oxymeter; a De-Facto Monitoring Device in Aluminum Phosphide, A Novel Approach Hossein Hassanian-Moghaddam1*, Mohammad Mashayekhian1, Shahin Shadnia1, Mitra Rahimi1, Abbas Aghabiklooei1, Ahmad Ghoochani1, Maryam Hassanian-Moghaddam2 and Abdolkarim Pajoumand1 1 Shahid Beheshti University of Medical Sciences, Iran, 2 Islamic Azad University of Mashhad, Iran P3-237 Oral Repeated-dose Toxicity Study of Icotinib Hydrochloride in Beagle Dogs Jin Hongtao1, Wei Jinfeng1, Huang Mingfang2, Wang Yinxiang3 and Wang Aiping4* 1 Beijing Union-Genius Pharma Inc,IMM,CAMS, China, 2 Beijing Union-Genius Pharma Inc, China, 3 Zhejiang Beta Pharma Inc., China, 4 Zhejiang Beta Pharma Inc.,IMM,CAMS, China P3-238 Comparative Investigation of Contact Sensitization Potency of Fragrance Mix and Fragrance Mix Ingredients by using Ex Vivo LLNA-BrdU Asuman Karakaya1*, Ozge C Ulker1 and Yesim Kaymak2 1 Ankara University, Turkey, 2 Gazi University Health Center,Turkey P3-239 Hematologic Studies of Acute and Sub-chronic Oral Toxicity in Rat with Xanthrones Extracted from Pericarp of Garcinia Mangostana Linn Pakamon Khumleu1, Aekkarin Klinkhamhom1, Aunchalee Sirimontaporn1, Thanaporn Pinpart1, Kanokporn Chayaburakul2, Kanchana Kengkoom1*, Rapee Inpunkaew1, Sumate Ampawong1 and Khuanjit Chaimongkolnukul3 1 Mahidol University, Thailand, 2 Rangsit University, Thailand, 3 Academic Services Offi ce, Thailand P3-240 Effi cacy Study and Hematologic Toxicity of PLEC-depots Containing SN-38 in U-87MG-Bearing Mice Chawan Manaspon, Khuanjit Chaimongkolnukul, Kanchana Kengkoom and Norased Nasongkla* Mahidol University, Thailand P3-241 Local Irritation and Skin Sensitization Study of TiO2 Sangsik Lee, Hyukju Ko, Hyeonyeol Ryu, Junetaek Lim, Dongseck Beck, Seonghyuk Kim, Jinkyu Lee, Jaebin Song and Kyungseuk Song Toxicity Evaluation Center, Korea Conformity Laboratory (KCL), Korea P3-242 Repeated Dose 90-Day Oral Toxicity Study of TiO2 in SD Rats Kyu-Sup Ahn1, Jin-Kyu Lee1*, Kyung-Seuk Song1, Jae-Hyuck Seong1, Hye-Jin Kim1, Won-Kwen Kuk1, Hyeon-Yeol Ryu1, Min-Won Baek1, Byung-Gil Choi1, Jae-Hak Park2,Won-Koo Hwang1 and Jae-Bin Song1 1 Toxicity Evaluation Center, Korea Conformity Laboratory (KCL), Korea, 2Seoul Natonal Uniersity, Korea P3-243 Validation of Quantifi cation Analysis for Recombinant Human Growth Hormone Doping in Blood by Sandwich ELISA Ju-Hyung Park1, Ji-Hye Woo2, Jaeick Lee1, Oh-Seung Kwon1 and Junghyun Son1* 1 Korea Institute of Science and Technology, Korea, 2 Korea University, Korea P3-244 Toxicity Assessment of JRN in Animal Models Kwang Hyun Hwang1, Jin Woo Park1, Yasuo Tarumoto1, Je Hein Kim1, Jae Young An2, Jin Hwa Lee2, Chang Min Kang1 and Heon Ju Lee1* 1 Toxicity Screening Center, Gyeongnam Environmental and Toxicology Department, KIT, Korea, 2 JR Co., Ltd., Korea P3-245 Development of Guidance Document for Korean Toxicological Testing Guideline Jun-Young Yang, Chae-Hyung Lim, Young-Na Yum, Joo-Hwan Kim, Yong-Kyoung Lee, Il-Young Ahn, Soon-Young Han and Ki-Hwan Choi* Korea Food and Drug Administration, Korea P3-246 Cytotoxicity of Fogucid in Biocide Hyo-Seon Yang1, Yongju Heo1, Chang-Ee Park2, Da-Young Shin2, Ha-Ryong Kim2, Kyu-Hyuck Chung2 and Kyuhong Lee1* 1 Inhalation Toxicology Center, Korea Institute of Toxicology, Korea, 2 Sungkyunkwan University, Korea P3-247 Acute and Sub-acute Oral Toxicity Assessment of CMDD3977, CMDD1514 and CMDD3125 in Animal Models Kwang Hyun Hwang1, Jin Woo Park1, Yasuo Tarumoto1, Seon Min Lee1, Dong Yup Hahn2, Heon Joong Kang2*, Yeon Gyu Moon1, Heon Ju Lee1*, Chang Min Kang1 and Ju Hong Lee1 1 Toxicity Screening Center, Gyeongnam Environmental and Toxicology Department, KIT, Korea, 2 Seoul Natonal Uniersity, Korea P3-248 Acute and Sub-acute Oral, Acute Dermal and Mucosal Toxicity Assessment of EEJE in Animal Models Kwang Hyun Hwang1, Jin Woo Park1, Yasuo Tarumoto1, Tae Kil Tak1, Da Im Jung2, Du Seog Jung2, Je Hein Kim1, Chang Min Kang1 and Heon Ju Lee1* 1 Gyeongnam Environmental and Toxicology Department, KIT, Korea, 2 Eeje Cosmedical 1033 Korea Bio21 Center, Korea The XIII 116 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-249 Safety of HJP, a Dietary Supplement; Results of 4-Week and 13-Week Oral Repeated Dose Toxicities in Rats Jung-Ho Noh1, Kwang-Hyun Lim1, Hee-Jin Park1, Eun Ju Jeong1, Yong-Soon Kim2, Byung-Cheol Han2, Seung-Ho Lee2, Yong-Baik Cho2 and Kyoung-Sik Moon1* 1 Korea Institute of Toxicology, Korea, 2 Korea Ginseng Corp., Korea P3-250 Target-based Drug Toxicity Evaluation with GPScreenTM HT using S. Pombe Genome-wide Deletion Mutant Library for Early Stage Drug Prioritization Dong-Myung Kim*, Ju-Hee Lee and Ji-Hyun Yeon Bioneer Inc., Korea P3-251 Feasibility of Simultaneous Measurement of Cytosolic Calcium and Hydrogen Peroxide in Vascular Smooth Muscle Cells Jung-Min Park, Jun-Hyeong Lee, Yingqiu Liu, Seok-Jeong Oh and Moo-Yeol Lee* Dongguk University, Korea P3-252 Safety Evaluation of a Biopesticide JGM127 in Animal Models Kwang Hyun Hwang1, Je Hein Kim1, Jin Woo Park1, Yasuo Tarumoto1, Seon Min Lee1, Heon Ju Lee1, Jung Eun Lee2, Young Ryun Chung2*, Chang Min Kang1 and Yeon Gyu Moon1 1 Gyeongnam Environmental and Toxicology Department, KIT, Korea, 2 Gyeongsang National University, Korea P3-253 Development and Validation of a Quantitative Assay Method for Bezaﬁ brate Tablet in KPC 3 Naroo Kang, Hyunju Moon, Seonhee Kim and Daehyun Cho* Center for Food and Drug Analysis, Gyeongin Regional Food & Drug Administration, Korea P3-254 A 13-Week Repeated Dose Toxicity of Cyperi Rhizoma Administered by Oral Gavage in F344 Rats Hyoung-Yun Han1, So-Ri Han1, Hee-Jin Park1, Soo-Nam Kim1, Su-Cheol Han1, Moon-Koo Chung1 and Byung-Sun Min2* 1 Korea Institute of Toxicology, Korea, 2 Catholic University of Daegu, Korea P3-255 Analytical Method Validation for Determining the Content of Oleic acid in Freeze-dried Tenebrio molitor by GC-FID Hee-Jin Yu1, Sang-Mi Jung1, Jae-Hwan Kim1, Sang-Hwa Choi1, Jong-Su Seo1, Kyu-Hong Lee2, Mi-Ra Jun3, Eun-Young Yun4, Jae Sam Hwang4 and Kyoung-Sik Moon5 1 Analytical Research Center, Korea Institute of Toxicology, Korea, 2 Inhalation Toxicology Center, Korea Institute of Toxicology, Korea, 3 Dong-A University, Korea, 4 National Academy of Agricultural Science, Korea, 5 Korea Institute of Toxicology, Korea P3-256 Effect of Different Concentrations of Nitrite on Sulfur-oxidizing Bacteria in an Online Toxicity Monitoring System Woochang Kang, Anup Gurung, Beom-Soo Shin and Sang-Eun Oh* Kangwon National University, Korea P3-257 Acute Oral Toxicity Test of Traditional Chinese Medicine on Crude Radix Aconiti Lateralis Preparata in Kunmin Mice Hongjun Wang, Tiezhong Zhou, Yingzi Liu, Dongliang Fei, Yugang Su and Hong Jiang* Liaoning Medical University, China

P3-258 ~ 275 : Toxicokinetics and Toxicodynamics P3-258 Intestinal Absorbability and Blood Retentivity of Sub-nano Platinum Manami Yamaguchi1, Yasuo Yoshioka1*, Tokuyuki Yoshida1, Miyuki Uji1, Kazuki Misato1, Asako Udaka1, Takahide Mori1, Shin- Ichi Tsunoda2, Kazuma Higashisaka1 and Yasuo Tsutsumi1* 1 Osaka University, Japan, 2 Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation (NiBio), Japan P3-259 Species and Inter-individual Differences in Metabolism of di(2-ethylhexyl) Phthalate between Human and Mouse Livers Yuki Ito1*, Michihiro Kamijima1, Chie Hasegawa1, Toshio Kawai2, Mio Miyake1, Yumi Hayashi1, Hisao Naito1 and Tamie Nakajima1 1 Nagoya City University Graduate School of Medical Sciences, Japan, 2 Osaka Occupational Health Service Center and Japan Industrial Safety & Health, Japan The XIII International Congress POSTER / JULY 3 (WED) 117 of Toxicology

P3-260 Weed or Wheel! fMRI, Psychomotor and Toxicological Investigations of How Weed Inhalation Affects Skills Required for Safe Driving in Occasional and Heavy Cannabis Smokers Christian C Giroud-Kim1*, Giovanni Battistella2, Marie Fabritius1, Eleonora Fornari3, Haitchem Chtioui4, Jean-Frederic Mall5, Monique Appenzeller4, Jean-Marie Annoni6, Bernard Favrat1, Thierry Buclin4, Christian Staub1, Philippe Maeder4 and Patrice Mangin1 1 CURML, Switzerland, 2 CHUV and University of Lausanne, Switzerland, 3 CHUV and CIBM (Centre d'Imagerie Biomedicale), Switzerland, 4 CHUV, Switzerland, 5 SUPAA, CHUV, Switzerland, 6 University of Fribourg, Switzerland P3-261 Toxicokinetics of Domoic Acid in Pregnant and Non-pregnant Mice after Repeated Oral Administrations Ju Young Park, Mtohiro Shiotani*, Sungwoo Hong, Dale Whittington, Toby Cole, William C Griffi th, Thomas M Burbacher, Lucio G Costa and Elaine M Faustman University of Washington, USA P3-262 Development of an Automated in Vivo Microdialysis Coupled with On-line Column-switching LC-ESI-MS/ MS Method for Continuously Profi ling Primary Acrylamide Metabolites in Rat Blood Yu-Syuan Luo1, Tai-Ying Long1, Li-Ching Shen2, Tung-Hu Tsai3 and Kuen-Yuh Wu1* 1 National Taiwan University, Taiwan, 2 National Chiao Tung University, Taiwan, 3 National Yang-Ming University, Taiwan P3-263 The Study of Pharmacokinetics and Effect of Perfl uoroundecanoic Acid in Male rats Chen-Tse Su1, Kuen-Yuh Wu1*, Su-Yin Chiang2* and Huai-Jen Tsai1* 1 National Taiwan University, Taiwan, 2 China Medical University, Taiwan P3-264 The Treatment of Rats with a Mixtures of Perfl uorinated Chemicals Potentially Inducing Effects on their Pharmacokinetics Chia-Yun Wu National Taiwan University, Taiwan P3-265 The Study of Potential Interaction of Co-exposure to Suspected Endocrine Disrupting Pesticides Iprodione and Fenvalerate in SD Rats Chun-Han Su1, Chen-Tse Su1, Tai-Ying Long1, Bau-Suei Chang2, Kuen-Yuh Wu1* and Su-Yin Chiang2* 1 National Taiwan University, Taiwan, 2 China Medical University, Taiwan P3-266 Bayesian Calibration of a Generic Physiologically based Pharmacokinetic (PBPK) Model using Experimental End-exhaled Air Levels of Toluene, Styrene and n-Hexane Marc-Andre Verner1*, Robin Mcdougall2, Ginette Charest-Tardif3, Robert Tardif3 and Gunnar Johanson1 1 Karolinska Institutet, Sweden, 2 University of Ontario Institute of Technology, Canada, 3 Universite de Montreal, Canada P3-267 The Study of Xenobiotic Metabolism Phase II Reactions in Pigs: High Sulfotransferase Enzymatic Effi ciency Observed by in Vitro Kinetic Analyses Aksorn Saengtienchai*, Yoshinori Ikenaka, Wageh S Darwish, Yusuke K Kawai, Shouta M Nakayama, Shigeo Ito and Mayumi Ishizuka Hokkaido University, Japan P3-268 Effects of Cyclosporine Pretreatment on Pharmacokinetics of Digoxin and Pravastatin in Rats; Importance of Absolute Bioavailability Comparison in Drug-drug Interactions Young Hyun Ji, Guk Hwa Jung, Sun Young Kim, Kyu-Bong Kim, Ryu Sung Ha and Yoon Gyoon Kim* Dankook Univeristy, Korea P3-269 Characteristics of Percutaneous Absorption of Phthalate as Plasticizer Eunha Oh1*, Kyong-Sok Shin1, Jonghyeon Choi1, Yun Kyung Chung2 and Hosub Lim1 1 Neodin Medical Institute, Korea, 2 Hallym University Scared Heart Hospital, Korea P3-270 Negligible Drug Interaction of Red Ginseng and Antihypertensive Agent, Amlodipine in Sprague-dawley Rats Sung Ha Ryu, Ji Won Kim and Kyu-Bong Kim* Dankook University, Korea P3-271 The Simplest Network Stating the Mechanisms for Organic Xenobiotics-induced Toxicity: Is it Possible to Accept as 'Central Dogma' of Organic Toxicology? Yeong-Chul Park Catholic University of Daegu, Korea The XIII 118 POSTER / JULY 3 (WED) International Congress of Toxicology

P3-272 Tissue Distribution and Excretion of Zinc Oxide Nanoparticles in Rats after Oral Administration and Intravenous Injection Jonghye Choi1, Hyejin Kim1, Yeonjin Lee1, Kwangsik Park1*, Pilje Kim2, Kyunghee Choi2, Hyunmi Kim2 and Enhye Jo2 1 Dongduk Women's Uiversity, Korea, 2 NIER, Korea P3-273 Pharmacokinetics and Tissue Distribution of Glycidamide in Sprague Dawley Rats Jeong Cheol Shin1, Jin Ho Choi1, Soyoung Shin2 and Beom Soo Shin1* 1 Catholic University of Daegu, Korea, 2 Wonkwang University, Korea P3-274 Pharmacokinetics of Arylamide and its Ative Mtabolite, Gycidamide in Sprague Dawley Rts Jin Ho Choi1, Won Sik Seo2, Kyu-Bong Kim3, Jung Cheol Shin1, Soyoung Shin4 and Beom Soo Shin1* 1 Catholic University of Daegu, Korea, 2 Boryung Pharmaceutical Company, Korea, 3 Dankook University, Korea, 4 Wonkwang University, Korea P3-275 Physiologically based Pharmacokinetic Model of Acrylamide and its Active Metabolite, Glycidamide in Rats and Humans Won Sik Seo1, Kyu-Bong Kim2, Soyoung Shin3 and Beom Soo Shin4* 1 Boryung Pharmaceutical Company, Korea, 2 Dankook University, Korea, 3 Wonkwang University, Korea, 4 Catholic University of Daegu, Korea

Late Breaking Abstracts P3-276 Sodium Chloride: Safety Evaluation and Risk Assessment Min Kyung Shin, Hyung Sik Kim and Byung-Mu Lee Sungkyunkwan University, Korea P3-277 Identiﬁ cation of Biomarker for Genotoxic Carcinogenic Toxicity using Analysis of Gene Yhun Y Y Sheen1*, Bo M Kang1, In-Hye Kwon1, So J. Moon1, Kyoung T. No2, Ho J. Kwon2 and Do Y Yoon3 1 Ewha Womans University, Korea, 2 Yonsei University, Korea, 3 Kunkuk University, Korea P3-278 Triclosan Induces Alteration of Sperm Production and Morphology through Its Accumulation in the Epididymis of Sprague-Dawley Male Rats Hyung Sik Kim1*, Zhou Lan2, Tae Hyung Kim2, Eui Kyung Lee2, Seong Kwang Lim1 and Byung Mu Lee1 1 Sungkyunkwan University, Korea, 2 Pusan National University, Korea P3-279 Psammaplin a Induces Autophagy Cell Death via SIRT1/p53/DRAM Pathway in Doxorubicin-resistant Human Breast Cancer MCF-7/adr Cells Hyung Sik Kim1*, Tae Hyung Kim2, Eun Young Park2, Bu Young Chung1 and Byung Mu Lee1 1 Sungkyunkwan University, Korea, 2 Pusan National University, Korea P3-280 Evaluation of Metabolomic Proﬁ ling against Renal Toxicity in Sprague-dawley Rats Treated with Melamine and Cyanuric Acid Hyung Sik Kim1*, Tae Hyung Kim2, Eun Young Park2, Eui Kyung Lee2, Kundu Soma2, Minji Kim1 and Byung Mu Lee1 1 Sungkyunkwan University, Korea, 2 Pusan National University, Korea P3-281 Cisplatin Induces Autophagic Cell Death in Normal Human Kidney Proximal Tubular Epithelial Cells Hyung Sik Kim1*, Tae Hyung Kim2, Eui Kyung Lee2, Eun Young Park2, Min Kyung Shin1, Dahee Lee1 and Byung Mu Lee1 1 Sungkyunkwan University, Korea, 2 Pusan National University, Korea P3-282 Transgenerational Epigenetic Effects of Bisphenol-A on Adult Onset Disease Hyung Sik Kim1*, Kundu Soma2, Eun Young Park2, Eui Kyung Lee2, Hyun Jong Park1, Hye Min Park1 and Byung Mu Lee1 1 Sungkyunkwan University, Korea, 2 Pusan National University, Korea P3-283 Toxicogenomics Anlaysis for Nephrotoxicity Biomarkers Byung Mu Lee*, Hyun Jong Park, Seong Kwang Lim, Hye Min Park, Mi Jung Kwon, Min Ju Kim, Min Ji Kim, Bu Young Chung, Min Kyung Shin, Da Hee Lee, Du Yeon Bang and Hyung Sik Kim Sungkyunkwan University, Korea The XIII International Congress POSTER / JULY 3 (WED) 119 of Toxicology

P3-284 Chemopreventive Effects of Naringenin and Betaine on the Mixture of Benzo(A)Pyrene and N-Nitrosodimethylamine in Hepg2 Cells Byung Mu Lee*, Hye Min Park, Mi Jung Kwon, Min Ju Kim, Min Ji Kim, Bu Young Chung, Min Kyung Shin, Hyun Jong Park, Da Hee Lee, Du Yeon Bang and Hyung Sik Kim Sungkyunkwan University, Korea P3-285 Synergistic Reproductive Toxicity of Di(2-Ethylhexyl) Phthalate (Dehp) and Dibutyl Phthalate (Dbp) in Rats Byung Mu Lee1*, Min Ju Kim1, Min Ji Kim1, Bu Young Chung1, Min Kyung Shin1, Hye Min Park1, Hyun Jong Park1, Da Hee Lee1, Min Young Kwak1 and Hyung Sik Kim2 1 Sungkyunkwan University, Korea, 2 Sungkyunkwan University, Korea P3-286 Effect on Inﬂ ammatory Response in Wistar Rat treated with Different Size of Iron Oxide Particles by Intratracheal Instillation Jong Kwon Lee1, Tae Sung Kim1, A Young Jeong1, Sang Min Lee1, Ji Young Bae1, Ji Hyun Seok1, Hang Sik Roh1, Yeon Ji Park1, Saet Byul Cho1, Ji-Hyun Yun1, Hye Kyung Choi1, Chi Won Song1, Wan Sub Cho2, Soon Young Han1 and Jayoung Jeong1* 1 National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Korea, 2 Dong-A University, Korea P3-287 Safety Challenges of Nanohealth Products in Iran: Regulatory Issues and Effectiveness Sepideh Arbabi Bidgoli1*, Seyed Mahdi Rezayat1, Saeed Sarkar2 and L Pezeshk3 1 Islamic Azad University, Iran, 2 Tehran University of Medical Sciences, Iran, 3 Ministry of Health and Medical Education, Iran The XIII 120 POSTER / JULY 3 (WED) International Congress of Toxicology

EO-P01 ~ 06 : Environmental Exposure and Toxicity, an Integrated OMICS Approach EO-P01 Application of Environmental Metabolomics for the Identifi cation of Adverse Effect Caused by Pollutants in the Environment Seung-Ryul Hwang, Yu-Mi Park, Il-Gyu Kim, Sang-Min Kim, Eun-Young Kang and Min-Jin Lee National Institute of Environmental Research, Korea EO-P02 Saccharomyces Cerevisiae OMICS as the Tools of Environmental Monitoring for Chemicals, Radiation and Physical Stresses Hitoshi Iwahashi Gifu University, Japan EO-P03 Interspecies Difference of CYP1A Inducibility among Different Four Species Fish Exposed to Waterborne Benzo(a)pyrene Jin Wuk lee, June Woo Park and Sung Kyu Lee Korea Institute of Toxicology, Korea EO-P04 Investigation of Transcriptomic Response of Nanomaterials in Chironomus Riparius using RNA- Sequencing (RNA-seq) Sun-Young Park and Jinhee Choi University of Seoul, Korea EO-P05 Molecular and Genomic Approach for Understanding the Gene-environment Interaction between Nrf2 Defi ciency and Carcinogenic Nickel-induced DNA Damage Young Rok Seo Dongguk University, Korea EO-P06 Monitoring the Occurrence of Living Modifi ed Organisms (LMO) both around Cultivated Fields and at TMR (Total Mixed Ration) Sites in Korea Hae-Ryong Song, Eungro Park, Sunjung Kim and Hyen Mi Chung National Institute of Environmental Research, Korea

EO-P07 : Environmental Genomics EO-P07 Identiﬁ cation of Korean Local Sediment Species, Glyptotendipes Tokunagai as a Sediment Toxicity Monitoring Species using Ecotoxicogenomics-proteomic Approachs Si-Won Lee, Sun-Young Park, Min-Jeong Baek, Yeon-Jae Bae and Jinhee Choi University of Seoul, Korea

EO-P08 : Genotoxicity EO-P08 DNA Damage Response and Eventual Cell Death as a Function of Pmk-1 Status in the Silver Nanoparticles Exposed C.Elegans Nivedita Chatterjee and Jinhee Choi University of Seoul, Korea

EO -P09 : High-throughput Next Generation Sequencing Methods and Applications EO-P09 Transcriptome de novo Assembly Sequencing and Genetic Characterization of Toxic Dinoﬂ agellate Alexandrium Catenella Zhenghong Sui, Kyoung Ho Kang, Shu Zhang, Lianpeng Chang, Jinhua Ma, Wei Zhou, Jinguo Wang, Liliang Guo and Huili Geng Ocean University of China, China

EO-P10 ~ 14 : Human Microbiome and Microbial OMICS EO-P10 Modiﬁ cation of Energy Metabolism in Escherichia Coli Responsible for Ceftriaxone Resistance Sanying Wang, Jianyi Pan and Xuanxian Peng Xiamen University, China The XIII International Congress POSTER / JULY 3 (WED) 121 of Toxicology

EO-P11 Metabolic Resistance to V. parahaemolyticus Infection using Integrated OMICs Approach Xinhai Chen, Hui Li and Xuanxian Peng Sun Yat-Sen University, China EO-P12 Aluminum Nanoparticles Induces ERK and p38MAPK Activation in Brain of Rats Jung-Taek Kwon, Hyun-Mi Kim, Gyun-Baek Seo, Eunhye Jo, Mimi Lee, Ilseob Shim, Pilje Kima and Kyunghee Choi National Institute of Environmental Research, Korea EO-P13 Gene Expression in Rat Lung After Inhalation Exposure to Chloramines T Ilseob Shim, Hyun-Mi Kim, Jung Taek Kwon, Kyun-Baek Seo, Mimi Lee, Pilje Kim and Kyunghee Choi National Institute of Environmental Research, Korea EO-P14 Metabolomic Analysis of Metabolites in Edwardsiella Tarda Strains Yubin Su, Chang Guo, Sitong Ren, Hui Li and Xuanxian Peng Sun Yat-sen University, China

EO-P15 ~ 20 : Mechanisms of Toxicity: Genomics-based and Mechanism-based Biomarkers EO-P15 MiRNA-152 targets DNA Methyltransferase 1 in NiS-transformed Cells via a Feedback Mechanism Weidong Ji, Lei Yang, Jianhui Yuan, Linqing Yang, Mei Zhang, Defeng Qi, Xiaolu Duan, Aiguo Xuan, Wenjuan Zhang, Jiachun Lu, Zhixiong Zhuang and Guohua Zeng The First Aﬃ liated Hospital of Guangzhou Medical University, China EO-P16 Towards System-level Understandings of Transcriptional Regulations Yutaka Suzuki and Sumio Sugano Tokyo University, Japan EO-P17 Crucial Immune-related Molecules in Response to Bacterial Infection and Immunization in Amphioxus Haili Zhang, Xian-Jie Liu, Bing-Wen Zhang, Xuan-Xian Peng and Hui Li Sun Yat-Sen University, China EO-P18 Effects of Exposure to 1-Bromopropane on Glutamate Receptor in Rat Hippocampus Xiangrong Song, Wang Hailan, Zhao Na, Wu Jin, Jiang Liuquan and Zhang Wei Guangdong Province Hospital for Occupational Diseases Prevention and Treatmen, China EO-P19 Serum miR-206 and miR-133b as a Potential Biomarker for Lung Carcinogenesis Induced by 4-(Methylnitrosamino)-1-(3-pyridyl) -1-Butanone Jianjun Wu, Jinkun Huang, Ti Yang, Xun Li, Qiaoyuan Yang, Rong Liu, Yuanqi Li, Chengfeng Yang and Yiguo Jiang Guangzhou Medical University, China EO-P20 Exposure to 1-Bromopropane Induces Ionotropic Glutamate Receptor Changes in the Rat Cerebral Cortex Jin Wu, Xiangrong Song, Hailan Wang, Na Zhao, Hongling Li and Wei Zhang Guangdong Province Hospital for Occupational Diseases prevention and treatment, China

EO-P21 ~ 35 : Molecular and Cellular Toxicity Mechanisms and Adverse Health Outcomes EO-P21 Silica Nanoparticles Induce Endocytosis-dependent Reproductive Toxicity in Caenohabditis Elegans Hyun-Jeong Eom, JungMin Ahn and Jinhee Choi University of Seoul, Korea EO-P22 Alignment-Free Comparison of Metagenomic Samples with Supervised and Unsupervised Machine Learning Approaches Xuegong Zhang Tsinghua University, China EO-P23 Genotoxic and Epigenetic Alterations in 16HBE Cells Induced by Cr(VI) Bo Xia, Lin-Qing Yang, Hai-Yan Huang, Li Pang, Qing-Cheng Liu, Jian-Hui Yuan, Wen-Xu Hong, Xi-Fei Yang, De-Sheng Wu, Li Zhou, Xi-Feng Huang, Jian-Jun Liu and Zhi-Xiong Zhuang Shenzhen Centre for Disease Control and Prevention, China The XIII 122 POSTER / JULY 3 (WED) International Congress of Toxicology

EO-P24 The Epigenetic Silencing of Foxa2 in Cellular Replicative and Premature Senescence Induced by Hydrogen Peroxide Wenjuan Zhang, Weidong Ji, Linqing Yang, Jianping Yang, Yuling Xu and Zhixiong Zhuang Southern Medical University, China EO-P25 Oxidative Stress and Molecular-level Effects of Citrate Coated Silver Nanoparticles (AgNPs) Exposure on Earthworm, Eisenia Fetida Jin Soo Choi, Hyun Jung and June-Woo Park Korea Institute of Toxicology Gyeongnam, Korea

EO-P26 Methylation of PARP-1 Promoter Involved in the Regulation of Nano-SiO2-induced Decrease of PARP-1 mRNA Expression Chunmei Gong, Gonghua Tao, Linqing Yang, Jianjun Liu, Qingchen Liu and Zhixiong Zhuang Shenzhen Center for Chronic Disease Control, China EO-P27 New Insights into the Molecular Mechanisms of Poly(ADP-ribosyl)ation Response to Benzo(a)pyrene- induced DNA Damage Haiyan Huang, Zhixiong Zhuang, Jianjun Liu, Linqing Yang, Desheng Wu, Qingcheng Liu, Bo Xia, Jianfeng Cai, Xinfeng Huang and Jianqing Zhang Shenzhen Center for Disease Control and Preventio, China EO-P28 Functional Analysis of the Expressed Genes Exposed to Nano Oxides Hyun-Mi Kim, Eunhye Jo, Il Seob Shim, Jung Taek Kwon, Gyoun-Baek Seo, Mi-Mi Lee, Pil Je Kim and Kyunghee Choi National Institute of Environmental Research, Korea EO-P29 Further Studies on Cadmium-Adapted Lung Cells: Attenuation of General Stress Response, Enhancement of Metallothionein-Induction Response, and Loss of p53 Expression Andy T. Y. Lau, Yan-Ming Xu, Yuan Zhou, Dong-Yang Huang, Jian Zhang and Jen-Fu Chiu Shantou University Medical College, China EO-P30 Aberrant Expression of miR-133b-5p and miR-377-3p Associate with Neurotoxicity of 1-Bromopropane Jiang liuquan, Li hongling, Zhao na, Song xiangrong and Hailan Wang Guangdong Province Hospital for Occupational Diseases Prevention and Treatment, China EO-P31 Characterization of Toxical Effect Induced by Melamine and Cyanuric Acid in Combination in Male SD Rats Desheng Wu, Linqing Yang, Jianjun Liu, Xinyun Xu, Haiyan Huang, Xifei yang, Li Zhou, Wenxu Hong, Xinfeng Huang, Jianhui Yuan and Zhixiong Zhuang Shenzhen Center for Disease Control and Prevention, China EO-P32 Effect of Low Dose Bisphenol A on the Early Differentiation of Human Embryonic Stem Cells into Mammary Epithelial Cells Linqing Yang, Lingfeng Luo, Weidong Ji, Chunmei Gong, Desheng Wu, Haiyan Huang,Qingcheng Liu, Bo Xia, Gonghua Hu, Wenjuan Zhang, Qian Zhang, Jianjun Liu, Wenchang Zhang and Zhixiong Zhuang Shenzhen Center for Disease Control and Prevention, China EO-P33 A Functional Polymorphism in miR-27a Gene is Associated with the Reduction of Gastric Cancer Risk Qiaoyuan Yang, Zhigang Jie, Sheng Ye, Zhengrong Li, Zhiyuan Han, Jianjun Wu, Chengfeng Yang and Yiguo Jiang Guangzhou Medical University, China EO-P34 Ce-Duox1/BLI-3 Mediated Oxidative Stress in Silver Nanoparticles Exposed Caenorhabditis Elegans JiSu Yang, Nivedita Chatterjee, Jeong-Min Ahn and Jinhee Choi University of Seoul, Korea EO-P35 Liver Injury Associated with Skin Damage Induced by Trichloroethylene and its Metabolites in Guinea Pigs Zhao Na, Song Xiangrong, Li Hongling, Liu Lili, Huang Yongshun and Wang hailan Guangdong Province Hospital for Occupational Diseases prevention and treatment, China The XIII International Congress POSTER / JULY 3 (WED) 123 of Toxicology

EO-P36 : OMICS Data, Bioinformatics, and Mathematic Modeling EO-P36 Systems Level OMICs Data Analysis. Case Studies on Pathway Analysis and Causal Networks Yin Li and Yuri Nikolsky Thomson Reuters, China

EO-P37 ~ 39 : Protein Responses to Environmental Exposures EO-P37 Proteomic Investigation for Interaction between Fish Plasma Proteins and Outer Membrane Proteins of Edwardsiella Tarda Xiaoyan Huang, Hui Li and Xuanxian Peng Sun Yat-sen University, China EO-P38 Identiﬁ cation of the Proteins Related to SET-mediated Hepatic Cytotoxicity of Trichloroethylene by Proteomic Analysis Jianjun Liu, Xiaohu Ren, Xifei Yang, Wenxu Hong, Wei Liu, Jinbo Ye, Peiwu Huang, Haiyan Huang, Xinfeng Huang, Fan Yang, Liming Shen and Zhixiong Zhuang Shenzhen Center for Disease Control and Prevention, China EO-P39 Proteomic Investigation for Interaction between Fish Live Proteins and Outer Membrane Proteins of Edwardsiella Tarda Qingfeng Zhu, Hui Li and Xuanxian Peng Sun Yat-sen University, China

EO-P40 ~ 44 : Systems Ecotoxicology EO-P40 Systematically Detecting the Genetic Mechanism of Antipsychotic Drug Induced Side Effects based on Pathway and Network Analyses Tieliu Shi, Yanli Liu, Guanting Zhang and Zhenghui Yi East China Normal University, China EO-P41 Determination of Poly Aromatic Hydrocarbon Level in Water from Pengkalan Cheap River, Kelantan state, Malaysia during Wet and Dry Season Noor Zuhartini Binti Md Muslim, Seyed Reza Hashemi Babahidari and Mohamad Pauzi Zakaria Universiti Sains Malaysia, Malaysia EO-P42 The Epigenetic Effect of Trichloroethylene on Human Lymphocyte and the Related Biomarker Xueqin Yang, Zhixiong Zhuang, Xianqing Huang, Jianjun Liu, Linqing Yang, Haiyan Huang, Changye Hui and Wen Zhang Shenzhen Prevention and Treatment Center for Occupational Diseases, China EO-P43 Integrative Cyanobacterial DNA Microarray for the Harmful Algal Bloom in Korean Freshwater Chang Soo Lee Korea Research Institute of Bioscience and Biotechnology, Korea EO-P44 A mechanistic Study of Mercury Toxicity in Marine Medaka via Proteomics Minghua Wang Xiamen University, China

Late Breaking Abstract EO-P45 Evaluation of 2,4-Dichlorophenoxyacetic Acid-induced Neuronal Damage: A Neurotoxicological Study on Wistar Rat Mohammad Faisal Siddiqui, Anjum Ara, Shamim J Rizvi, M. Mobarak Hossain Aligarh Muslim University, India