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Research Summary JULIA EVE BECK [email protected] | 1234 Notre Dame Ave Notre Dame, IN 46556 | 765-366-6195 Education University of Notre Dame - Notre Dame, IN Anticipated May 2017 Ph.D. Biochemistry, Department of Chemistry and Biochemistry Advisor: Dr. Francis Castellino Dissertation Topic: Study of Components in the Human Fibrinolytic System: Platelet Activation in Traumatic Brain Injury and Plasminogen Activation in Bacterial Infection DePauw University – Greencastle, IN May 2011 B.A. Biochemistry IUPUI Wells Center/Riley Hospital – Indianapolis, IN March 2007 Molecular Medicine in Action Program Professional Skills Technical: Polymerase Chain Reaction Protein expression and purification Restriction digest and ligation Fast protein liquid chromatography Site directed mutagenesis Binding and activity assays Cellular transformation and Analytical Ultracentrifugation transfection Surface Plasmon Resonance Computational: Serial cloner Molprobity Prism SedFit Chimera SedNTerp Research Experience University of Notre Dame – Notre Dame, IN June 2013 - Present Graduate Research Assistant, Dept. of Chemistry and Biochemistry Advisor: Dr. Francis Castellino • Express human and bacterial proteins with various expression systems including E. coli, S2 Drosophila cells, and Pichia pastoris. • Study protein interaction using surface plasmon resonance, analytical ultracentrifugation, and activation assays. University of Notre Dame – Notre Dame, IN Aug. 2011 - June 2013 Graduate Research Assistant, Dept. of Chemistry and Biochemistry Advisors: Dr. Francis Castellino, Dr. Victoria Ploplis, and Ms. Deborah Donahue • Developed model to study platelet dysfunction in brain injured rats. • Analyzed blood coagulation parameters using thromboelastogram, hemostasis analyzer, and complete blood count. University of South Alabama – Mobile, AL May 2010 - July 2011 Undergraduate Research Assistant, Dept. of Pharmacology Advisors: Dr. June Ayling and Dr. Luai Hasoun • Developed a method to extract and quantify folate from human skin using methanol precipitation and High-Performance Liquid Chromatography. • Summer internship under auspices of National Science Foundation Research Experiences for Undergraduates (NSF-REU) program entitled “Structure and Function of Proteins”. DePauw University – Greencastle, IN Jan. 2010 - May 2011 Undergraduate Research Assistant, Dept. of Chemistry and Biochemistry Advisor: Dr. Jeff Hansen • Performed organic synthesis and analyzed results using spectroscopy. DePauw University – Greencastle, IN Jan. 2008 - May 2009 Undergraduate Research Assistant, Dept. Chemistry and Biochemistry Advisor: Dr. Dan Gurnon • Performed a range of lab techniques, including PCR, DNA purification, gel analysis, DNA sequencing, restriction digests, protein expression trials, and troubleshooting. DePauw University – Greencastle, IN Aug. 2007 - Dec. 2007 Undergraduate Research Assistant, Geology Department Advisor: Dr. Tim Cope • Studied the correlation between mountain range and basin areas to determine petroleum deposits. Wabash College – Crawfordsville, IN May 2007 - July 2007 Summer Research Student Advisor: Dr. Becky Sparks-Thissen and Dr. Ann Taylor • Performed a range of lab techniques, including PCR, plating, protein expression and purification under the guidance of Dr. Ann Taylor. • Studied effect of household chemicals on the growth and inhibition of a range of common bacterial strains. Professional Experience University of Notre Dame – Notre Dame, IN June 2016 - present Keck Center Focus Group Meeting Leader • Leader duties include planning, organizing, managing, and recording results of weekly meetings. XVth International Workshop: Sep. 2015 Molecular and Cellular Biology of Plasminogen Activation – Rome, Italy Session Co-chair • Co-chair duties included managing session of workshop. Publications 1. Butera D, Wind T, Lay AJ, Beck J, Castellino FJ, Hogg PJ. Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation. J. Biol Chem. (2014) 289 (5): 2992-3000. 2. Donahue DL, Beck J, Fritz B, Davis P, Sandoval-Cooper MJ, Thomas SG, Yount RA, Walsh M, Ploplis VA, Castellino FJ. Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. J. Neurotrauma. (2014) 31 (4): 404-10. Selected Presentations 1. Beck, Julia, Victoria A. Ploplis, Francis J. Castellino (September 25, 2015) “The Role of Lysine Binding Sites (LBS) within the Kringle Domains of Plasminogen in PAM Binding”, XVth International Workshop: Molecular and Cellular Biologyof Plasminogen Activation, Rome, Italy 2. Beck, Julia, Deborah Donahue, Victoria A. Ploplis, Francis J. Castellino (June11, 2013) “Platelet Dysfunction in a Rodent Model of Traumatic Brain Injury”, 18th Biochemistry Retreat, Department of Chemistry and Biochemistry, University of Notre Dame 3. Beck, Julia June Ayling, Luai Hasoun (July 30, 2010) “The Role of Skin Pigmentation in the Protection of Enzyme Cofactors”, NSF-REU program on “Structure and Function of Proteins”, University of South Alabama Grants & Fellowships Graduate Student Union Conference Presentation Grant July 2015 University of Notre Dame Graduate Assistant in Areas of National Need Fellow Jan. 2014 - present University of Notre Dame, Dept. of Chemistry and Biochemistry Science Research Fellow Aug. 2007 - May 2011 DePauw University Honors & Awards Outstanding Poster Award for Graduate Students Sept. 2015 XVth International Workshop: Molecular and Cellular Biology of Plasminogen Activation Dept. of Chemistry and Biochemistry Travel Award July 2015 University of Notre Dame Old Gold Honors Award Aug. 2007 - May 2011 DePauw University Professional Memberships American Association for the Advancement of Science Jan. 2014 - present Phi Lambda Upsilon, National Chemistry Honorary Fraternity May 2011 Phi Alpha Theta, National History Honor Society May 2011 Research Summary I am graduate student at the University of Notre Dame under the tutelage of Dr. Francis Castellino, Director of the W.M. Keck Center for Transgene Research. Our research at the Keck Center is focused on the human fibrinolytic system and how it relates to traumatic brain injury, stroke, and infection. My first research experience under the guidance of Dr. Castellino involved developing a rodent model of traumatic brain injury. This work resulted in a publication in the Journal of Neurotrauma. Our findings have directly impacted how doctors treat patients who have suffered a traumatic brain injury. Based on our work at the Keck Center and in collaboration with Memorial South Bend Hospital, doctors have changed how they administer key fluids like fresh frozen plasma and platelets, which have lead to an improved prognosis for the patient. My current work is focused on studying the interaction of the human protein plasminogen and a virulence factor found on the surface of Group A Streptoccocus called PAM. Previous studies have shown a correlation between the interaction of plasminogen and PAM and virulence of the bacteria. Recently I had the opportunity to present my work at the XVth International Workshop: Molecular and Cellular Biology of Plasminogen Activation in Rome, Italy. The aim of this work is to better understand this important interaction between plasminogen and PAM and how it relates to virulence. My work at the Keck Center aligns with one of my core values, which is to use research to understand and alleviate those suffering from medical ailments. NEIL T BERKEL 20 Longshot Dr. • Troy, IL 62294 • (618) 558-1133 • [email protected] EDUCATION UNIVERSITY OF NOTRE DAME Notre Dame, IN Master of Science, Physical Chemistry Expected January 2017 GPA: 3.648/4.000 MCKENDREE UNIVERSITY Lebanon, IL Bachelor of Science, Chemistry May 2015 Minors: Biochemistry & Mathematics GPA: 3.985/4.000 Summa Cum Laude Recipient of Outstanding Senior Chemistry (2015) and Outstanding Junior Chemistry Student (2014) RESEARCH EXPERIENCE UNIVERSITY OF NOTRE DAME Notre Dame, IN Graduate Research/Teaching Assistant August 2015 – Present • Developed methodology for computational screening of ferrocene-type ligands in asymmetric catalysis • Collaborated with a large pharmaceutical company to implement method in process chemistry workflow • Applied both quantum mechanical and classical force field methods • Refined computer skills when working with in-house python code • Instructed 15+ students in several organic laboratory courses and ensured laboratory safety MCKENDREE UNIVERSITY Lebanon, IL Undergraduate Research Assistant January 2014 – May 2015 • Developed methodology for prediction of relative product yields in electrophilic addition reactions • Modeled kinetics and thermodynamics of mentioned reactions • Solved problems and applied creativity by designing original work PROFESSIONAL EXPERIENCE SIGMA-ALDRICH St. Louis, MO Summer Intern, Quality Control May 2014 – August 2014 • Replaced product that was used in QC assays to ensure continued sales of 10.5 million dollars per year • Updated operating procedures to implement the new product under quality guidelines LEADERSHIP & SERVICE VARSITY TENNIS McKendree University August 2013 – May 2015 • Committed 20+ hours weekly as a student-athlete in practices, work-out sessions, and competition Lewis & Clark Community College August 2011 – May 2013 • Co-Captain and MVP for 2012 - 2013 season th • Led team to best finish in school history: 8 Place at the 2013 National Tournament MISSION TRIPS East St. Louis, IL – High Poverty Area March 2015 • Helped distribute food for
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