M1 turquoise

synaptic transmission Ontology Types transferrin transport maturation Biological Process axon guidance glutamate secretion Molecular Function proton−transporting ATPase activity, rotational mechanism domain specific binding Cellular Component GABA receptor activity glutamate receptor activity cytoskeletal protein binding synapse part synapse cell junction neuron projection plasma membrane

0 2 4 6 8 10 12 14

Z Score

M2 blue M3 brown

respiratory electron transport chain ensheathment of neurons mitochondrial transport nucleosome assembly tricarboxylic acid cycle tissue regeneration mitochondrial respiratory chain complex assembly actin filament−based movement NADH dehydrogenase complex assembly negative regulation of protein complex disassembly NADH dehydrogenase activity microfilament motor activity monovalent inorganic cation transmembrane transporter activity actin binding metal cluster binding Rho GTPase binding electron carrier activity ADP binding oxidoreductase activity, acting on a heme group of donors carboxypeptidase activity mitochondrial part nucleosome mitochondrion myelin sheath respiratory chain NADH dehydrogenase complex axon part proton−transporting ATP synthase complex, catalytic core F(1) −coated vesicle

0 10 20 30 40 0 2 4 6 8

Z Score Z Score

M4 yellow M5 green

axon guidance cell−cell signaling signaling G−protein coupled receptor protein signaling pathway calcium ion transport regulation of small GTPase mediated establishment of protein localization glutamate signaling pathway cellular response to glucagon stimulus regulation of neurological system process calcium channel regulator activity GTPase activator activity GTPase activity lipase activity SNAP receptor activity extracellular ligand−gated ion channel activity voltage−gated calcium channel activity transmembrane receptor activity guanyl nucleotide binding anion channel activity membrane postsynaptic membrane synapse part postsynaptic density synapse plasma membrane plasma membrane part synapse vesicle membrane part

0 2 4 6 8 0 2 4 6 8

Z Score Z Score M6 red M7 black

translation cellular aldehyde metabolic process peptide metabolic process stress−activated MAPK cascade tRNA metabolic process hexose biosynthetic process oxoacid metabolic process glucose metabolic process protein processing alcohol catabolic process structural constituent of ribosome phosphoprotein binding translation regulator activity protein homodimerization activity acyl−CoA dehydrogenase activity receptor signaling protein activity rRNA binding catalytic activity flavin adenine dinucleotide binding ribosome magnesium ion binding mitochondrion cytosol mitochondrial small ribosomal subunit cytoplasm mitochondrial large ribosomal subunit proteasome complex mitochondrial nucleoid soluble fraction

0 5 10 15 20 25 30 0 2 4 6 8

Z Score Z Score

M8 pink M9 magenta

protein transport cholesterol metabolic process post−Golgi vesicle−mediated transport tRNA metabolic process nuclear transport proteolysis GTP catabolic process skeletal system development regulation of defense response to virus by virus gamete generation protein transporter activity activity, hydrolyzing O−glycosyl compounds GTPase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GTP binding serine−type peptidase activity ubiquitin−protein ligase activity ligase activity thiolester hydrolase activity nuclease activity membrane coat Golgi transport complex ubiquitin ligase complex microbody part endosome peroxisome protein serine/threonine phosphatase complex trans−Golgi network endosome membrane microsome

0 2 4 6 8 0 2 4 6 8 10

Z Score Z Score

M10 purple M11 greenyellow

regulation of Ras protein signal transduction establishment or maintenance of apical/basal cell polarity protein modification process leukocyte cell−cell adhesion induction of by extracellular signals cell−matrix adhesion nerve growth factor receptor signaling pathway cell−substrate junction assembly regulation of cell development cell projection assembly protein serine/threonine kinase activity actin binding guanyl−nucleotide exchange factor activity integrin binding transferase activity, transferring hexosyl groups oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GTPase activator activity zinc ion binding ATP binding calcium ion binding actin filament cytoskeleton cell projection cell−substrate junction cell projection part cytoplasm early endosome ruffle cytoplasm basolateral plasma membrane

0 1 2 3 4 5 6 0 2 4 6 8 10

Z Score Z Score M12 tan M13 salmon

regulation of protein complex disassembly nuclear mRNA splicing, via spliceosome muscle contraction termination of RNA polymerase II transcription regulation of cytoskeleton organization protein−DNA complex subunit organization response to mechanical stimulus expression actin filament organization mRNA transport cytoskeletal protein binding nucleic acid binding structural constituent of muscle ATP−dependent activity binding chromatin binding anion transmembrane transporter activity nucleic acid binding transcription factor activity protein domain specific binding DNA−dependent ATPase activity adherens junction spliceosomal complex cytoskeleton nucleoplasm plasma membrane small nuclear ribonucleoprotein complex cell−substrate junction nucleus cytoplasm nuclear body

0 2 4 6 8 0 5 10 15 20 25

Z Score Z Score

M14 cyan M15 midnightblue

'de novo' posttranslational protein folding phosphorus metabolic process glycolysis negative regulation of activity mitosis establishment of localization G1/S transition of mitotic cell cycle hormone metabolic process cellular protein complex assembly regulation of cyclic nucleotide metabolic process unfolded protein binding protein kinase regulator activity regulator activity protein serine/threonine kinase activity GTPase activity GTPase activity purine ribonucleotide binding enzyme activator activity phosphatase activity purine ribonucleotide binding chaperonin−containing T−complex cytoplasmic membrane−bounded vesicle prefoldin complex cell projection part cytoplasm plasma membrane cytoskeleton neuronal cell body cytoskeletal part plasma membrane part

0 5 10 15 0 2 4 6 8

Z Score Z Score

M16 lightcyan M17 grey60

negative regulation of protein complex disassembly RNA capping regulation of translation transcription−coupled nucleotide−excision repair negative regulation of cytoskeleton organization ncRNA processing establishment of RNA localization positive regulation of viral transcription mRNA metabolic process transcription elongation from RNA polymerase II promoter RNA binding DNA−directed RNA polymerase activity enzyme inhibitor activity ribonuclease activity nucleic acid binding transcription factor activity endonuclease activity nucleus methyltransferase activity ribonucleoprotein complex nucleic acid binding nuclear membrane nuclear part non−membrane−bounded organelle nucleus microtubule lysosome

0 1 2 3 4 5 6 0 2 4 6

Z Score Z Score M18 lightgreen M19 lightyellow

mRNA processing regulation of axonogenesis RNA splicing positive regulation of phosphorylation regulation of RNA metabolic process stress−activated protein kinase signaling cascade transcription, DNA−dependent negative regulation of cell differentiation positive regulation of gene expression neuron projection morphogenesis nucleic acid binding receptor activity nucleic acid binding transcription factor activity small conjugating protein ligase activity transcription factor binding transcription factor activity GTPase regulator activity transcription factor binding site of polarized growth nuclear hormone receptor binding membrane nucleus intrinsic to membrane nuclear part Golgi apparatus part chromatin axon part

0 5 10 15 0 1 2 3 4 5

Z Score Z Score

M20 royalblue M21 darkred

RNA splicing antigen processing and presentation mRNA processing interferon−gamma−mediated signaling pathway regulation of immune response chromosome organization immune response mRNA export from nucleus neutrophil chemotaxis termination of RNA polymerase II transcription heme binding nucleic acid binding receptor activity RS domain binding protein homodimerization activity chromatin binding carbohydrate binding Ras GTPase activator activity histone binding MHC protein complex zinc ion binding receptor complex nucleus ruffle nuclear part external side of plasma membrane chromosomal part extracellular region

0 5 10 15 0 5 10 15 20

Z Score Z Score

M22 darkgreen M23 darkturquoise

regulation of Ras GTPase activity protein phosphorylation signal transduction response to radiation cytoskeleton organization metal ion transport system development ligand−gated channel activity voltage−gated cation channel activity actin binding enzyme regulator activity cytoskeletal protein binding GTPase regulator activity protein serine/threonine kinase activity neuron spine postsynaptic density plasma membrane postsynaptic membrane synapse cytoskeleton cell junction

0 2 4 6 8 10 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5

Z Score Z Score M24 darkgrey M25 orange

protein ubiquitination nicotinamide nucleotide metabolic process Ras protein signal transduction monosaccharide catabolic process anion transport monosaccharide biosynthetic process positive regulation of protein ubiquitination xenobiotic metabolic process response to steroid hormone stimulus cellular modified amino acid metabolic process nucleotidyltransferase activity oxidoreductase activity, acting on the CH−OH group of donors, NAD or NADP as acceptor ligase activity, forming carbon−nitrogen bonds cofactor binding anion transmembrane transporter activity peptidase activity, acting on L−amino acid peptides zinc ion binding ligase activity purine ribonucleoside triphosphate binding ubiquitin ligase complex nucleotide binding vacuolar part cytoplasm vacuole microtubule associated complex integral to plasma membrane cytosol endosome soluble fraction

0 1 2 3 4 5 6 0 2 4 6 8

Z Score Z Score

M26 darkorange M27 white

protein activation cascade extracellular matrix organization acute−phase response biological adhesion platelet degranulation skeletal system development negative regulation of endopeptidase activity muscle structure development lipoprotein metabolic process muscle contraction endopeptidase inhibitor activity extracellular matrix structural constituent cell surface binding platelet−derived growth factor binding heparin binding extracellular matrix binding oxygen binding structural constituent of muscle serine−type endopeptidase activity collagen binding vesicle lumen extracellular matrix part extracellular region extracellular matrix protein−lipid complex extracellular region extracellular space extracellular space membrane attack complex stress fiber

0 5 10 15 20 25 30 0 5 10 15 20 25 30 35

Z Score Z Score

M28 skyblue M29 saddlebrown

viral transcription protein N−linked glycosylation via asparagine post−translational protein modification endocrine pancreas development protein folding translational termination tRNA aminoacylation for protein translation viral infectious cycle translation translational elongation transferase activity, transferring hexosyl groups structural constituent of ribosome unfolded protein binding RNA binding translation factor activity, nucleic acid binding cytosolic small ribosomal subunit carbohydrate binding endoplasmic reticulum lumen ribosome endoplasmic reticulum cytosolic large ribosomal subunit melanosome eukaryotic translation initiation factor 3 complex endoplasmic reticulum membrane intracellular microsome

0 10 20 30 40 50 0 5 10 15

Z Score Z Score M30 steelblue M31 paleturquoise

regulation of cellular amino acid metabolic process monovalent inorganic cation transport signal transduction involved in cell cycle checkpoint transmembrane transport M/G1 transition of mitotic cell cycle regulation of system process negative regulation of ubiquitin−protein ligase activity involved in mitotic cell cycle behavior positive regulation of ubiquitin−protein ligase activity involved in mitotic cell cycle system development protein dimerization activity cation channel activity protein complex binding calcium ion binding enzyme binding active transmembrane transporter activity proteasome complex juxtaparanode region of axon proteasome regulatory particle cation channel complex cell fraction apical plasma membrane endoplasmic reticulum membrane integral to membrane cytoplasm axon

0 5 10 15 20 25 0 5 10 15

Z Score Z Score

M32 violet M33 darkolivegreen

regulation of hormone secretion transmembrane transport alcohol metabolic process cellular amino acid metabolic process cofactor metabolic process exocytosis ion transport energy derivation by oxidation of organic compounds transmembrane transporter activity transmembrane transporter activity metal ion binding adenyl ribonucleotide binding neuron projection mitochondrion synapse cell junction mitochondrial membrane mitochondrion intrinsic to membrane intrinsic to membrane

0 1 2 3 4 5 6 0 1 2 3 4 5

Z Score Z Score

M34 darkmagenta M35 sienna3

GTP catabolic process nucleic acid metabolic process platelet activation chromosome organization regulation of body fluid levels regulation of immune response nucleic acid binding

nuclear transport hydrolase activity, acting on ester bonds GTP binding ligase activity GTPase activity identical protein binding nucleoplasm membrane part nucleus

plasma membrane chromosome endosome membrane nucleolus vesicle endosome ribonucleoprotein complex

0 1 2 3 4 5 6 0 1 2 3 4 5 6 7

Z Score Z Score M36 yellowgreen M37 skyblue3

neurotransmitter transport regulation of nucleotide metabolic process regulation of neurotransmitter levels cellular membrane organization signal release vesicle−mediated transport ion transport protein phosphorylation secretion by cell cell cycle secondary active transmembrane transporter activity protein domain specific binding substrate−specific transporter activity actin binding kinase activity GTP binding cytoplasmic vesicle part plasma membrane endosomal part mitochondrion endosome synapse cytosol mitochondrial membrane cytoplasm

0 2 4 6 8 0 1 2 3 4 5

Z Score Z Score

M38 plum1 M39 orangered4

protein folding translational initiation response to unfolded protein translation negative regulation of cell cycle protein targeting gene expression cell cycle process regulation of translation unfolded protein binding macromolecule catabolic process heat shock protein binding translation initiation factor activity chaperone binding isomerase activity activity receptor binding Golgi membrane melanosome cytosol endoplasmic reticulum lumen Golgi apparatus endoplasmic reticulum endoplasmic reticulum microtubule cytoskeleton cytoplasm

0 5 10 15 0 5 10 15

Z Score Z Score

M40 mediumpurple3 M41 lightsteelblue1

defense response to bacterium humoral immune response response to inorganic substance

immune effector process response to wounding

immune response activation of immune response response to external stimulus defense response transition metal ion binding

antigen binding extracellular region part

extracellular region extracellular region cytoplasmic membrane−bounded vesicle membrane fraction cytoskeleton

0 10 20 30 40 0 5 10 15

Z Score Z Score M42 lightcyan1 M43 ivory

negative regulation of cell growth

negative regulation of locomotion nucleotide metabolic process tissue morphogenesis negative regulation of response to stimulus cellular catabolic process regulation of cellular component movement glycosaminoglycan binding ribonucleoprotein binding extracellular matrix binding receptor binding RNA binding calcium ion binding enzyme inhibitor activity nucleoside− activity extracellular region extracellular region part purine ribonucleoside triphosphate binding integral to plasma membrane

0 5 10 15 0 2 4 6 8 10 12 14

Z Score Z Score

M44 floralwhite

viral transcription

endocrine pancreas development

translational termination

viral infectious cycle

translational elongation

structural constituent of ribosome

RNA binding

cytosolic large ribosomal subunit

ribosome

intracellular

cytosol

0 10 20 30 40 50

Z Score Eigenprotein Value Eigenprotein Value Eigenprotein Value -0.20 -0.15 Eigenprotein-0.10 -0.05 Value -0.20 -0.15 Eigenprotein-0.10 -0.05 Value Eigenprotein Value 0.00 0.05 0.10 0.00 0.05 0.10 -0.1 -0.2 -0.1 -0.3 -0.2 -0.1 -0.2 -0.1 0.0 0.1 0.2 0.3 0.0 0.1 0.0 0.1 0.0 0.1 AD vsCTTukeyp=0.00057 AD vsCTTukeyp=6.9e-11 AD vsCTTukeyp=8.2e-08 AD vsAsymADp=0.00093 AD vsCTTukeyp=0.0061 AD vsAsymADp=6.9e-11 AD vsAsymADp=4.4e-05 AD vsCTTukeyp=0.063 AD vsCTTukeyp=0.042 AD vsAsymADp=0.025 AD vsAsymADp=0.15 AD vsAsymADp=0.22 AsymAD vsCTp=0.64 AsymAD vsCTp=0.75 AsymAD vsCTp=0.76 AsymAD vsCTp=0.03 AsymAD vsCTp=0.11 AsymAD vsCTp=0.55 Control Control Control Control Control Control M1 turquoise M21 darkred M9 magenta M13 salmon M17 grey60 M5 green

AsymAD AsymAD AsymAD AsymAD AsymAD AsymAD

AD AD AD AD AD AD

Eigenprotein Value -0.20 -0.15 Eigenprotein-0.10 -0.05 Value -0.10 Eigenprotein-0.05 Value -0.15 -0.10 Eigenprotein-0.05 Value Eigenprotein Value -0.20 -0.15 Eigenprotein-0.10 -0.05 Value 0.00 0.05 0.10 0.00 0.05 0.10 0.15 0.20 0.00 0.05 0.10 0.00 0.05 0.10 0.15 -0.2 -0.1 -0.2 -0.1 0.0 0.1 0.0 0.1 AD vsCTTukeyp=6.9e-11 AD vsCTTukeyp=1.1e-10 AD vsCTTukeyp=3.7e-05 AD vsAsymADp=0.00015 AD vsAsymADp=8.4e-11 AD vsAsymADp=7.1e-06 AD vsCTTukeyp=2e-06 AD vsAsymADp=7e-11 AsymAD vsCTp=0.079 AD vsCTTukeyp=0.43 AD vsCTTukeyp=0.34 AD vsAsymADp=0.46 AsymAD vsCTp=0.97 AsymAD vsCTp=0.57 AsymAD vsCTp=0.91 AsymAD vsCTp=0.33 AsymAD vsCTp=0.23 Control Control Control AD vsAsymADp=1 Control Control Control M22 darkgreen M18 lightgreen M10 purple M14 cyan M2 blue M6 red

AsymAD AsymAD AsymAD AsymAD AsymAD AsymAD

AD AD AD AD AD AD -0.20 -0.15 -0.10 -0.05 -0.10 -0.05 -0.05 -0.20 -0.15 Eigenprotein-0.10 -0.05 Value -0.15 Eigenprotein-0.10 -0.05 Value Eigenprotein Value Eigenprotein Value Eigenprotein Value Eigenprotein Value 0.00 0.05 0.10 0.00 0.05 0.10 0.15 0.00 0.05 0.10 0.15 0.20 0.25 0.00 0.05 0.10 0.00 0.05 0.10 0.15 -0.1 0.0 0.1 0.2 0.3 AD vsCTTukeyp=0.00023 AD vsCTTukeyp=6.9e-11 AD vsCTTukeyp=6.9e-11 AD vsAsymADp=0.00037 AD vsAsymADp=1.2e-10 AD vsAsymADp=0.0084 AD vsCTTukeyp=0.015 AD vsCTTukeyp=0.033 AD vsCTTukeyp=0.033 AD vsAsymADp=7e-11 AD vsAsymADp=0.014 AD vsAsymADp=0.024 AsymAD vsCTp=0.083 AsymAD vsCTp=0.034 AsymAD vsCTp=0.73 AsymAD vsCTp=0.95 AsymAD vsCTp=0.9 AsymAD vsCTp=1 M23 darkturquoise Control Control Control M15 midnightblue Control Control Control M11 greenyellow M19 lightyellow M3 brown M7 black

AsymAD AsymAD AsymAD AsymAD AsymAD AsymAD

AD AD AD AD AD AD

-0.10 Eigenprotein-0.05 Value Eigenprotein Value Eigenprotein Value Eigenprotein Value -0.15 Eigenprotein-0.10 -0.05 Value Eigenprotein Value 0.00 0.05 0.10 0.15 0.00 0.05 0.10 0.15 -0.2 -0.1 -0.2 -0.1 -0.2 -0.1 -0.2 -0.1 0.0 0.1 0.0 0.1 0.2 0.0 0.1 0.0 0.1 AD vsCTTukeyp=9.7e-11 AD vsCTTukeyp=4.3e-10 AD vsCTTukeyp=1.7e-09 AD vsAsymADp=2.4e-09 AD vsAsymADp=3.5e-07 AD vsAsymADp=2e-07 AD vsAsymADp=0.071 AD vsCTTukeyp=0.42 AD vsCTTukeyp=0.62 AD vsAsymADp=0.94 AD vsAsymADp=0.82 AsymAD vsCTp=0.84 AsymAD vsCTp=0.58 AsymAD vsCTp=0.04 AsymAD vsCTp=0.37 AsymAD vsCTp=0.15 AD vsCTTukeyp=0.4 AsymAD vsCTp=0.9 Control Control Control Control Control Control M20 royalblue M16 lightcyan M24 darkgrey M4 yellow M12 tan M8 pink

AsymAD AsymAD AsymAD AsymAD AsymAD AsymAD

AD AD AD AD AD AD -0.15 -0.10 Eigenprotein-0.05 Value Eigenprotein Value -0.20 -0.15 Eigenprotein-0.10 -0.05 Value -0.15 -0.10 Eigenprotein-0.05 Value -0.15 -0.10 Eigenprotein-0.05 Value 0.00 0.05 0.10 0.15 0.00 0.05 0.10 0.00 0.05 0.10 0.15 0.00 0.05 0.10 0.15 -0.1 0.0 0.1 0.2 0.3 AD vsCTTukeyp=2.6e-07 AD vsCTTukeyp=0.0021 AD vsAsymADp=7.5e-08 AD vsAsymADp=2.8e-07 AD vsAsymADp=0.0022 AD vsCTTukeyp=1e-08 AD vsAsymADp=0.084 AD vsCTTukeyp=0.33 AD vsCTTukeyp=0.84 AD vsAsymADp=0.89 AsymAD vsCTp=0.84 AsymAD vsCTp=0.93 AsymAD vsCTp=0.77 AsymAD vsCTp=0.29 AsymAD vsCTp=0.98 M33 darkolivegreen M41 lightsteelblue1

Control Control Control Control M29 saddlebrown Control M37 skyblue3 M25 orange

AsymAD AsymAD AsymAD AsymAD AsymAD

AD AD AD AD AD

-0.10 Eigenprotein-0.05 Value Eigenprotein Value Eigenprotein Value Eigenprotein Value Eigenprotein Value 0.00 0.05 0.10 0.15 -0.1 -0.1 -0.1 -0.1 0.0 0.1 0.2 0.0 0.1 0.2 0.0 0.1 0.2 0.3 0.0 0.1 0.2 AD vsCTTukeyp=6.9e-11 AD vsAsymADp=1.4e-09 AsymAD vsCTp=6.9e-11 AD vsCTTukeyp=0.015 AD vsCTTukeyp=0.043 AD vsCTTukeyp=0.18 AD vsCTTukeyp=0.81 AD vsAsymADp=0.12 AD vsAsymADp=0.72 AD vsAsymADp=0.47 AsymAD vsCTp=0.48 AsymAD vsCTp=0.46 AD vsAsymADp=0.3 AsymAD vsCTp=0.7 AsymAD vsCTp=1

Control Control Control M34 darkmagenta Control Control M26 darkorange M42 lightcyan1 M30 steelblue M38 plum1

AsymAD AsymAD AsymAD AsymAD AsymAD

AD AD AD AD AD -0.10 -0.05 -0.15 -0.10 -0.05 -0.10 Eigenprotein-0.05 Value Eigenprotein Value Eigenprotein Value Eigenprotein Value Eigenprotein Value 0.00 0.05 0.10 0.15 0.00 0.05 0.10 0.15 0.00 0.05 0.10 0.15 0.20 -0.2 -0.1 -0.1 0.0 0.1 0.0 0.1 0.2 0.3 AD vsAsymADp=0.083 AD vsCTTukeyp=0.16 AD vsCTTukeyp=0.19 AD vsCTTukeyp=0.19 AD vsCTTukeyp=0.48 AD vsCTTukeyp=0.98 AD vsAsymADp=0.16 AD vsAsymADp=0.34 AD vsAsymADp=0.96 AD vsAsymADp=0.63 AsymAD vsCTp=0.97 AsymAD vsCTp=0.82 AsymAD vsCTp=0.34 AsymAD vsCTp=0.84 AsymAD vsCTp=1 Control Control Control Control M31 paleturquoise Control M39 orangered4 M35 sienna3 M27 white M43 ivory

AsymAD AsymAD AsymAD AsymAD AsymAD

AD AD AD AD AD -0.15 -0.10 -0.05 Eigenprotein Value -0.10 Eigenprotein-0.05 Value -0.10 Eigenprotein-0.05 Value -0.15 Eigenprotein-0.10 -0.05 Value Eigenprotein Value 0.00 0.05 0.10 0.00 0.05 0.10 0.15 0.20 0.00 0.05 0.10 0.00 0.05 0.10 0.15 -0.1 0.0 0.1 0.2 AD vsCTTukeyp=0.00086 AD vsCTTukeyp=7.8e-06 AD vsAsymADp=2.2e-07 AD vsCTTukeyp=0.033 AD vsAsymADp=4e-04 AD vsAsymADp=0.032 AD vsAsymADp=0.098 AD vsCTTukeyp=0.86 AD vsCTTukeyp=0.48 AD vsAsymADp=0.34 AsymAD vsCTp=0.24 AsymAD vsCTp=0.98 AsymAD vsCTp=0.71 AsymAD vsCTp=0.9 M40 mediumpurple3 Control Control Control AsymAD vsCTp=1 Control Control M36 yellowgreen M44 floralwhite M28 skyblue M32 violet

AsymAD AsymAD AsymAD AsymAD AsymAD

AD AD AD AD AD Module 1, n = 558, FDR Corrected pvalue 3.6797e-07 orange = Abeta Plaque darkblue = NFT KATNA1 green = Both

FRMPD4 ARF6 MACF1 ATP6V1G1 MACF1 NTRK3 REEP5 EPHB2 CBL ACSL3 CYTH2 DYRK1A HADH TENM3 PHYHIP GRM8 WDR47 WDR47 ABLIM3 CHRM1 BIRC2 CASK UHRF1BP1L NAA38 ARHGAP26 NTRK2 CENPE KCNIP4 CASK PTPRF KIF3B NTRK2 C2CD5 DLG2 CASK PAK7 UBXN6 OSBPL10 RABGAP1L GNG4 OSBP MADD BRAF MADD GPC1 BRAF PTK2B MAPK10 PREP GNAI1 SEPT14 RAP1GAP WDR13 PTPN5 LRFN3 CDH13 HTT WDR13 SLC7A5 TAC1 BCR LPHN1 COPS7A DGUOK C2CD2L NLGN4X SIRPA SLC25A23 SVOP LPHN1 GDAP1L1 MAGI2 PTPRG ARFGAP1 RCN2 CALCOCO1 YWHAB CADM2 SIRPA ROBO2 RAP1GAP2 ARFGAP1 OXR1 TBCK CTTNBP2 SEPT1 MBOAT7 MTPN PSMD8 CA4 CRYZL1 LASP1 AP3S1 NCK2 SYNGAP1 PRKCD ADD2 RAF1 PRICKLE2 CORO7 CDH18 YWHAH ADD2 LPCAT1 EHBP1 MAPK11 ARMC10 ARF3 SHC3 DNAJC19 NAV1 GRM2 MAP2K4 SPRYD4 PANX1 PGM2L1 SYNGR3 PCLO HK1 CD200 CRYM RFTN1 GIT2 LRRTM4 ATP6V1A SLC25A22 DNAL1 PCDHA11 ARPC2 CAMSAP3 PTPRR EPHA6 CA4 CRYM C1orf95 NEDD4L TDRKH CTBP2 PRKCG TRIO DNM3 TNR LCLAT1 SMAP1 PCDH1 ATP6V1G2 GGCT KIAA1217 SV2B PAK1 LANCL2 SLC39A6 GPM6A ACTN1 GDAP1 PDF SPTBN2 KRAS PCLO GABRA5 LYSMD1 BCAS3 PCDH1 SYT7 VPS52 VPS37B SSBP1 DLG1 SH3GLB2 FAM81A ACTN1 NRCAM NBEA CLTC EPS15L1 SYT7 ENTPD3 ARF5 ARPP21 ACTB PPP3CC CYLD ATL1 SNX30 PIGBOS1 EXOC3 NUMB PPM1H STXBP1 DPP6 NRXN3 AP2S1 EPHB6 CRMP1 STX1A ACTN1 PIN1 NTM ACTR2 TMEM163 PPP1R14C RDH14 SMIM18 RAB35 ARHGEF7 ATP6V1F GPRIN1 KIAA0513 UNC13B PLXND1 PURB PDDC1 SYT5 ATP6V0A1 HPCA APBB1 EPB41L4B SORBS2 EXOC6 GRIPAP1 PLXNA1 DMXL2 HOOK1 FRS3 PTPRS SYP CACNA2D1 RTN1 YJEFN3 AVL9 PPFIA3 SEMA4D GNAT3 FRRS1L SLC6A17 SRGAP3 ERC2 CAPN5 PCSK1 C2CD4C NUMBL KIAA1324 LRRC7 NECAB2 BAIAP2 GRIA1 GABBR2 SEPT11 MYO5A CPNE7 TBC1D10B PRR36 SNX4 STK24 STX17 SYT1 CTNNA2 ATP6V1C1 MAPRE3 AK5 AP2A2 SLC2A3 BECN1 CALB1 ARPC5L DNAH9 NECAB1 AP2M1 RAB14 SLC17A7 AKAP5 ERC2 ICA1L CSNK2B PSD NPTN DLG4 NRCAM BSN PACSIN1 AK5 PPP2R2C OPA1 ATCAY NDEL1 ANKS1B IQSEC2 ITPKA FAM126B MORN4 AP2M1 RIMBP2 RAB3A ACTR3B UNC13C NPTN SV2A NWD2 GRIN2B ICAM5 NCKAP1 VPS45 ANKS1B GSK3A NAA30 SMYD3 GGA1 ATP6V1E1 DLGAP3 GRIA2 AP3D1 GPM6B ATP6V1H EXOC8 SYT3 SKAP1 PIP5K1C CAMKV ELFN1 SYNGR1 ANKS1B TIPRL CSPG5 DENND4B IQSEC1 KIAA1045 CORO1A RPTOR BAI3 ABI2 DNAH8 SEPT6 GPD2 NRAS AP3M2 CORO1A AP3B2 ARFIP2 WASF1 HPCAL1 DCAF7 PPP2R5E PAK3 BRCC3 CA10 SLC30A3 CAMKV DGKB HOMER2 SH3GL1 GFOD1 PLXNC1 AP3B2 FAM213B RAB3GAP1 CSNK1G3 NYAP2 EPN1 ICA1 CHL1 GNL1 GDA RIMS1 FAF2 PVRL3 PALM UNC13A SLK PTK2 NECAP1 KATNB1 LRFN2 RAB15 ERC1 RIMS1 MYH10 KIAA1211L DENND1A TMEM178A ROGDI PACS1 PPP1R21 TGFBRAP1 BCAR1 DENR WDR7 CXADR

AP2B1 ATP6V1D MYH10 PTPRZ1 SHANK2 ANK2 GABBR1 DOC2A GABRB3 AP2B1 PACS1 CD47 LIN7A JAKMIP1 EXOC7 SNAP91 GNAZ BRK1 ATP6V1B2TBC1D24 ATP2B1 TMEFF1 CSNK2A1 PTPN9 LETM1 GABBR1 NAA35 NT5DC3 WASF3 RAB18 PTGES2 KATNAL1 GABRB1 CADM3 SPATA2 MAP6 GLRA3 ATL2 ZC2HC1A ARHGAP35 TMEM132B TIMM10B VSTM2L CTBP1 DBN1 NME8 ACTN2 SEPT5 NLGN3 SLC1A1 CTBP1 TMOD1 CDC42BPB MARK4 CACNA1C TOM1L2 PHACTR1 PPP3CB 0 ACTN2 SEPT5 ME3 PRKAR2A TRAPPC2L GNG13 GABRA2 MCTS1 EVL MARK2 C10orf35 OXLD1 SNAP25 PVRL1 NEGR1 PALM2 MRAS DNM1L ELFN2 ARL15 ILDR2 CYP4X1 BRSK2 SLC25A18 SNX7 TSTD1 INPP5A SH2D5 IGSF9B PPP2CA CNKSR2 LRRC40 MAPK9 FXYD6 PPFIA2 CDC42 SEPT7 THY1 RGS6 CADM1 STMN2 PPFIA2 CADM1 FLRT2 TSG101 RIMS2 SEPT7 WDFY1 PPFIA2 XKR4 MCM3AP PDE4D TTC39C SPTBN1 NCKIPSD LZTFL1 CLVS1 LPHN2 SLC1A4 PMM1 TAOK1 KCNMA1 USP7 C12orf57 FNBP1L EMD GGA3 SLC25A14 LRFN5 NLGN2 LRRC8B GRK5 PLCH2 RASGRF2 USP7 PIK3C3 TMEM178B HECW2 PIK3R4 VPS13A GRM7 SHOC2 GIT1 PKP4 LINGO2 CTNNB1 CTNNB1 TOR1A BAIAP3 FIBP ARHGEF12 SNX32 CCDC85A TSPAN7 GNG3 STRN KIRREL3 GATSL2 TBC1D7 TANC2 HGS TANC2 PDE4C DPYSL4 YWHAG DYRK2 RAPGEF3 C2orf69 LAMP5 STRN3

TTC9B Module 2, n = 403, FDR Corrected pvalue 1.6412e-14

0 0 0

UQCC1 0

SOD2 PPM1A

PPOX TRAP1 EIF4E APOOL COX7B TRAPPC12 SIRT5 SCCPDH KCND2 FXN NME3 ABHD12 CMC1

MT-ND2 C14orf2 NDUFB2 VDAC3 SDHAF2 CIAPIN1

ZADH2 SERAC1 ARHGAP26 FLII FDX1 GBAS FECH TXN2 BRI3BP VDAC3 SLC3A2 GBAS TMEM126B RDH13 TFAM CRELD1 ADCY1 STEAP2

COQ5 OPA3 ELMOD2 COX7A2 OPA3 NIPSNAP1 MT-ND1 CORO6 OXSM CHP1 UBE2C

GAD1 LYPLA1 CORO6 CKMT1A C19orf70 SMIM12 MECR ACAT1 GRAMD1B SLC25A44 SLC7A8 TOMM40L MTX2 MT-CO2 DBT ABAT C6orf203 NDUFV3 DNAJB4 TIMM50 LPCAT4 CMC2 CEND1 PPA2 TIMM8A MTX3 MT-ND5 NDUFA11 FAM210B CNNM2 SLC6A4 FH PMPCA IDH3A ETFB DLAT SUCLG1 NDUFA8 ATP2B2 MTIF3 SAMM50 PRDX3 GK SFXN1 MCU COA3 PCP4 COX5A SFXN1 ATP5O SLC25A4 DARS2 GUCY1A2 SDHB OGDHL DLAT HSD17B10 ABCC8 BCAT1 HSPD1 SLC25A5 SLC25A10 IDH3A COX4I1 MRRF ATP5I ATP5F1 HSPA9 HSPA4L GABRG2 NDUFS5 NDUFS7

COA6 TMX3 NDUFS8 NDUFB1 GLS TPBG SHMT2 DNAJA3 SYT2 NDUFS2 ATP1A2 MICU1

GCDH NDUFA7 DIRAS1 IDH3A DECR1 NDUFA10 MPC1 APOO ISCU NDUFB3 SPG7 TMEM126A GLS NDUFV2 ATP1A1 ZDHHC5 NDUFA7 NDUFC1 PARS2 NDUFA12 PDHA1 THNSL1 TIMM21

UQCRH ATP5E ATP1B1 MFN2 NDUFS6 CHCHD3 SNRK C6orf136 GRPEL1 SFXN4 SYAP1 CORO2A CCDC127 SUCLA2 DLD UQCRC2 NDUFB9 SLC22A23 ATP5H PHB2 ATAD1 ATP5A1 NNT AFG3L2 NDUFA2 ECHS1 CCDC58 KARS STAU2 BDH1 OGDH ATP1B2

CDH6 ATP2B3 IDH3G PHB NDUFS3 ATP1A3 NDUFV1 UQCRC1 NDUFB5 PDHX NDUFB8 LACE1 ACTN4 SLC13A5 SUPV3L1

UQCRB SDHA MKKS MTCH2 COQ9 SUOX ABHD10 PDHB NDUFS1 UQCRFS1P1 ACO2 NDUFB7 UQCRB NDUFA5 IDH3G CYC1 SLC25A6 LOC102724023 GMPS SLC25A11 NDUFC2 NCEH1 NOVA1 FUNDC1 PCCB NDUFB6 AIFM1 NFU1 TMEM65 DLST NFS1 DNAJC11

HINT2 MARS NDUFA13 NDUFB11 CYCS TOMM70A DCXR IARS2 NDUFA6 GFM1 SLC30A9 FAHD1 UQCRQ NDUFS4 ATP5B SARS2 NDUFAF2 COX5B RAPGEF4 SLC25A42 NDUFA4 UQCRFS1 MT-CO1

ETFDH ATP5B ISCA1 NDUFA9 COX6B1 SCO1 NT5C3A MPC2 MDH2 ACOT13 ALDH5A1 ELMOD1

NDUFA9 NDUFB4 ATPAF1 COX7C NDUFB10 NDUFAB1 TIMM10 ATP5C1 ADCK3

ATP5S MT-ATP6 TUFM TIMM13 LYRM1 ACN9 NTNG1 BCS1L OLFM2 TIMM9 CPT1A LRRC8A SLC25A3 AUH PDK3 ATP5J TOMM22 SLC27A4 LONP1 ATAD3A ATP5D MICU3 LRRFIP1 ECH1 COX7A2L NDUFA3 C2orf47 PURA TMEM63B IBA57 IDH3B FUNDC2 TRHDE UQCR10 LYRM4 ETFA PCCA IDH3B HSPE1 GABRB2 ERP44 MFF PLXNA4 STOML2 NDUFAF4 ETFA SLC4A4 HCN1 BOLA3 TIMM44 ISCA2 SNCG SLC25A19 VDAC1 SYNDIG1 FAM162A IMMT SDR39U1 RHOT1 MT-ND6 MT-ND4 MTX1 IMMT

HCCS CISD1 CHCHD4 FAM136A ADAM11 NDUFAF6 SFXN5 COA1 SLC12A5 PRRT3 CADPS2 AHCYL2 CACNG2 NDUFAF5 GCSH TMEM143 RMND1 MRPS36 OSBPL3 SLC16A7 NDUFAF3 SLC32A1 NUBPL FAM210A ME2 IGLON5 PNPT1 MLYCD ARMC1

PCDH11X VDAC2

TMED9 HTRA2 VDAC2 C1orf196 MT-CO3 CS ATP5L CS TK2 CKMT2 HSDL1 CLPB L2HGDH CADPS CADPS CADPS UQCC2

AGPAT5 ACTR2

SLC43A2 WARS2

GLDC PLCB2 SYNJ2BP-COX16 Module 3, n = 398, FDR Corrected pvalue 0.18123

C1orf27 PDS5A ARSA RFFL TUBA1A

PACS2

ISLR YBX1 FAM124A HIST1H1E MIF4GD GMPR2 HS1BP3 DEPTOR TARSL2 MID1IP1 KIAA0930 MYLK L3HYPDH LMBRD1 VAT1 ERLIN1

CPQ SNX9 SOX11

RAP1B ANK3 ANK3 STX4 ANK3 RILPL1 SH3BP4 RAP1B OTUD7A FTL NOTCH1

ZFYVE16 HSPB6 LBR STAG1 STXBP3 H1F0 GBE1 HIST2H2BC AAMDC CCDC88A TBCB GJC2 KLK6 WDFY2 HIST2H2AC TMC6 DOCK9

UEVLD RNH1 SUN2 KIF5B RECQL ATL3 APOD L1TD1 ABCB9 ASAH1 FCHO1 DHX29 H2AFX ABCA2 PLLP CD82 RAP1A PHLPP1 ATL3 SCN8A ANXA5 DLG2 KIF27 GNG7 GEMIN5 LITAF FRYL SPTLC2 IQGAP1 FBLN1 RASSF2 GPD1 GPR37 EPS15 LACTB2 APRT HSPA2 TSPAN15 PXK FBLN1 FGF1 KDSR CFL2 SEPT4 JOSD2 PLEKHG3 CAST ENPP6 SEPT4 MRI1 LGI3 SYNJ2 TPP1 ARHGAP17 PLCL1 SOX10 PGM3 OR1M1 WNK1 FOLH1 RDX ANKRD13A

FAM84B CNTN2 PLA2G16 SMC3 TEX2 AMPD3 MOBP PLP1 MOSPD2 HTATIP2

CATSPER2 CC2D1B FMNL2 CENPP SLAIN1 RRBP1 FNTB ARHGEF1 GANAB FNBP1 PMP2 CBR1 RPS6KA1

CPM LAMP2 PPFIBP2 MYO1E NUP210 TMEM63A FAM177A1 SLC44A1 GLTP ZC3H13 CMTM5 ENDOD1 UFL1 SH3PXD2B CADM4 CTNNA3 TALDO1 RRBP1 CLIC4 JAM3 SWAP70 SORT1

RTFDC1 NPC1 UGT8 LIPA MTMR10 VCAN ANLN HAPLN2 FUBP3 HIST1H1D SORT1 PCBP4 AIF1L DOCK5 MOG LGALS3BP OSTF1 DAAM2 DES TTYH2 CD9 HAPLN2 H2AFV CUTC GOLPH3 HIP1 MAG MSH2 VCAN QKI CA14 PLD1 IMPDH1 GM2A REEP3 S1PR5 NINJ2 LIPE MYO1D CNP ELMO1 RTKN CLMN SPTBN4 SEPSECS GNG8 TMCC3 BIN1 LDB3 QKI PLS3 TPPP3 ZDHHC20 PPP1R14A SIRT2 FAM107B ASPA GCLC SLC12A9 INA DOCK10 UBL3 PLEKHB1 OPALIN UNC5C ERLIN2 SIRT2 ERMN HIST2H3PS2 C1orf198 GOLGA7 INSR SBDS MBP GLIPR2 CDC42EP1 DOCK1 NDRG1

KTN1 LEMD2 HDAC11 ADAM10 C8orf46 MBP PIP4K2A RGS3 PLEKHB1 CARNS1 ACBD5 MCAM NUMA1 RHOG N4BP2L2 DYNC1I2 DDR1 KTN1 CYB5R2 HIST1H1B MBP PARP1

C2orf88 FNTA PDE1C 0 CLDND1 RBP7 CCP110 ATG4C CNDP1 TSPAN8 OMG PDE4B LLGL2

NEFL ITGA2 NEFM CERS2 0 ENPP2 QDPR SLC12A2 NFIC DERA

PRR18 OTUD7B FAM63A HNRNPF UAP1L1 NPC2 CA2 ABCA8 DNPEP BROX MSH6 USP54 EVI2A USP54 ELOVL1 CTPS2 INF2 CNTNAP1 LMNA KRT222 PDE8A PHLDB1 DSC2 PHLDA3 GAB1 CLDN11 C11orf73 CAPZB MYH14 PARP4 MYO9B ADSSL1 RP2 PRPH PHLDB1 GSN NFASC SEC23B ADA EDIL3 LAMP1 CDC42EP2 NFASC MYH14 TMC7 CNDP2 PRKAR1A MVP KIAA1598 CIB1 LZIC ERMP1 PACSIN3 MAP6D1 HN1L HEBP1 CBR3 DUSP26 AMER2 DFFA CDR2L CEP135

APLP1 MICALL1 PFN1 AMER2 DYNLT1 NAALAD2 PFN1 LPAR1 EFHD1 CPNE2 AP3B1 ACYP2 STAG2 CPPED1 DFFA NIN SYNGR2 EPN2 ABCC4 BCAS1 TNC SNX18 ABHD17B MPDZ BCAS1 FTH1 AHNAK2 TNC

UNC5B BCAS1 TNC

BCAS1 GIPC1 LANCL1 DPP3 ARHGEF10 MYO6 CRYAB H3F3B CRYAB CEP97 ECHDC1 FSCN1 ECHDC1 HIST1H4A PLS1 CHMP4A

SLCO3A1

IVNS1ABP RNASE1 SH3D19 CORO7 TJAP1 Module 4, n = 291, FDR Corrected pvalue 1.6684e-07

IGSF21 TMED8 LRRTM1

CNOT4 CACNB4

SH2B2 C12orf4 KIAA0195 WDR41 NRBF2 KCNA4 SH3BGRL2 C7orf43 TBC1D17 FAM134C TMEM263

IGSF8

CNTN1 CAMK2D SHF GPSM1 VPS11 PCDH8 SFXN3 TUSC2 ATAT1 CHMP6 TSSC1 CAMK2D

EPN1 PDXP CSNK1G1

SCN3A MKL1 CSNK2A2 CAMK2D PDXP C1QL3 MPP6 SEMA4D PPP1R16A GRM7 POTEF SPRED1 SLC17A8

EFNB3 AP2S1 FAM171A2 CNTN5 CAMK2D PPP3CA GNG2 EPHA7 CAPZA2 GMDS ARPC1A STX7 PGRMC1 PCDH19 ATP9A GNB1 PPP3CA TPD52 STX12 DLGAP1 VPS9D1 VPS33B TUBA1C PDE2A C9orf72 SLITRK5 NCAM2 GUK1 GNB1 TSC1 PDE2A VAMP2 AP1M1 ARPC4

GRM5 STK32C NADK2 CALB2 LPHN3 GNB2 RNF11 STRN3 GNB1 TPD52 BAG5 MYDGF TWF2 LRRC57 SPTBN1 RAB39B SMCR8 NUDT3 SCN2A DIAPH2 RAB1A MACROD2 DCUN1D3 NCS1 GNAO1 SLITRK4 ARHGEF7 NUDT10 RTN3 CACNA1E WDR37 KIF2A BASP1 HZGJ SRC CLTB TOLLIP CYB5B ITFG1 SYTL2 USP25 CNTN3 DNAJC5 PTPRA ATP6V0A1 SCAMP5 FAM175B CACNB2 ARHGAP1 GRIPAP1 SLC8A2 FAM171B ITSN1 SYN2 PTPRN2 GIT1 SNCA SYNPR CACNB3 RLTPR BSDC1 SCAMP1 SPATA33 CNRIP1 RAB2A PPM1F ATP6V0D1 MAP3K10 SH3GL3 CLTA YWHAE RAB12 AGAP3 APMAP CNIH2 RB1CC1 NPTXR ATP2B4 PRUNE2 PSD3 PIP4K2B CLTA RAB3C PLEKHA1 RAP2A AGAP3 EHD3 SEPT3 RAP2B EPHA4 RAPGEF6 FYN L1CAM AP3S1 CALM2 CACNA2D3 CHID1 NCAM1 DNM1 NSF WDR48 GAP43 AGAP3 GGT7 UBXN2B MCUR1 PRKAR2B STX1B APBA1 CNR1 ALDOA TOM1L1 CAMK2A GNB4 VAMP3 MYRIP NCAM1 OPCML GSPT2 VPS26B CLTC SLC30A1 HMGCLL1 MYH10 RAB33B HRAS AK4 DPP10 SCN3B CPNE8 VAMP7 LGALSL ATP6AP1 SYT17 VPS29 NRXN1 ANK2 NSG2 MBLAC2 SNAP29 BCAS3 PGBD5 YWHAZ ANK2 SNX5 CPNE5 SH3GL2 ATG12 DAAM1 RAPGEF2 RAB23 TPM3 KCTD16 PTPRN GRIK2 INPP4A YKT6 DLG2 DLG2 RAB11A C1QL2 HPRT1 SLC9A6 XKR6 MYL6B GNB3 NIPAL3

SPTAN1 SYN1 ZFYVE21 NRXN2 RAPGEF2 LIN7B SPTAN1 PRKCB RAB9B CLSTN1 MAL2 PRKCB CCDC90B

UNC5A REPS1 SYN1

CLSTN1 UNC5A IGBP1 PCDH7 RAPGEF2 RCN1 EFNB2 RTN4RL2 RRAS2 CDH2 C1orf116 RALBP1

PRKACA

CNTN4 PCDH7 RASGEF1A VPS33A POR TTC9 RASAL1 USP43 PGRMC2 STRIP1 NCAN

NFASC FAM13C

NEDD8 TUBA4A ACVR2A Module 5, n = 249, FDR Corrected pvalue 1

UBA52 TSC22D2 PDZD2

ARMC10 PDK1

LYRM2 PRKG2

C19orf52 TRAF2 PDE4D PNPLA8 WDR26 IRGQ CELF2 HSPA13 COL4A3BP NETO1 DCLK1 LRRC4

DCLK1 OGT RHEB RGS7BP BNIP3L KIF3A PPP1R16B OXCT1 IL1RAPL1 CELF5 OXCT1 FDX1L FAM19A5 ARHGEF9

RAPH1 TMEM132E GID8 CCNYL1 ARC CACNG8 BEGAIN ARMCX3 ROCK2 BRINP2 CBLN4 TTC7B DNAJC6 KCNJ4 KCNMA1 TAMM41 CAP2 RALGAPA1 STXBP5L HTR2A CDH9 BEGAIN

LZTS1 AGPAT1 PRMT8 TAGLN3 ACSL4 RPH3A RASA2 BRINP1 NRN1 LINGO1 DDHD1 AP1B1 CAP2 ROBO2 SLC25A27 PURG PPEF1 DOC2B MAGI1 ASIC1 SYNE1 PTGFRN TLN2 KCNB2 DAGLA SHISA7 PLCL2 IL1RAP RGS7 ERGIC1 SGIP1 GPR158 GFRA2 GABRA1 TENM4 EFR3B CNTNAP5 GRIA4 SLC8A3 RAB11FIP2 OLFM3 TTPAL GAD2 EML6 GSK3B HOMER1 PKP2 SGIP1 GRM3 SPRY2 MAPK8 SYT12 PITPNM3 RAPGEF4 PI4KA SST KALRN SORCS1

SYNGAP1 CDH10 UBE3A ARHGAP44 RFK AGK ASTN1 SCAI SH2D3C CSMD2 SLC39A10 RASAL2 AGAP2 MMAA NOS1 OLFM1 PLXNA3 CPLX3 ITPR1 CDH8 GPC1 CACNG3 GRIN1

RGS12 DLGAP4 CPNE4 MARK1 EVI5L NCALD MDGA2 AFAP1L2 DGKI DLG3 NF1 EPHA5 KIAA1549L PCYOX1L SHANK2 TENM2 SRGAP2 PLCB1 PLXNA2 RALGAPB SHANK2 SH3GLB2 GRIA3 LRRC75A GABRG2 NPTX2 PRKCE KIAA1549 RHOF C19orf26 SH3GLB1 VGF FBXO41 TTYH3 VWC2 GRIA3 ATP2A3 ZNF365 NUDT14 BAI2 ITSN2 KIF5C AHCYL1 SMPD3 ADORA1 AMIGO1 KIF21A CHCHD6 ERO1L KIAA1468 AAK1 LRRC73 GNB5 GABRD PPM1E PICK1 RAB3GAP2 DLG1

TSPAN13 EEA1 ABHD16A TRIM32 MGLL MAEA TTYH1 SLC25A46 FARSB IDH2 CAMSAP1 DLGAP2 ASAP1 CTNND1 ARL4C NRXN3 ATP2A2 STRN4 CECR6 DGKE FMN2 PDCD10 PGAM5 ARHGEF11 ADCYAP1 NSMF TMEM38A LRRTM3 SPRED3 DGKZ SUB1 NTNG2 ABCB10 CCRN4L NRBP1 PPP1R13B

SEC23A TOMM40 GARNL3 GOPC FAM102B USP32

KIFC2 MPV17 DLGAP1 DLGAP1 CACNA1A RANBP9

CPEB4 CEP170B

POMGNT2 UGGT2

SNX25 SRGAP3 ABRACL Module 6, n = 248, FDR Corrected pvalue 1

FASTKD5 RGMA LRP1B NOP14 BRSK1

HSPA12B

TRAPPC4

GATC

PIGK TRMT11 RABAC1 AACS LARS2 GLCE PDXDC1 ANGEL2

LIAS TMEM177 XRCC4

HACL1 AADAT PIGT NCLN GATB HERC1 MRPL32 NUDT9 RMDN1 BIRC6 KANK3 RHOT2 MAP3K13 YTHDC2

QRSL1 FBLN7 EEF1B2 MTERF4 UBR3 FEM1B TMEM259 MALSU1 SNX10 NICN1 PPTC7 SLC25A40 MRPS11 MRM1 MRPL30 DOPEY2 ACSF3 NOA1 FAM160A2 MRPL2 CTH

PDP1 ACAD10 MRPS12 SPCS1 LDHD PPAPDC3 MRPL9 CRAT PTPMT1 MRPL38 MRPS25 IDI1 SLC38A1 ADCK1 TFB1M TACO1 GADD45GIP1 MRPS33 MRPS28

PITPNM1 BTBD11 EARS2 CLUH MRPL20 ERGIC3 MRPL10 MRPL1 MRPL44 GFM2 MRPS23 MRPS26 MRPS34 TBRG4 MRPL45 SLC25A32 MRPL12 SLC22A18 MRPS10 LYRM7 MIPEP ZDHHC17 MRPS35 YARS2 OAT SPCS3 MRPL11 MRPL43 BOLA1 ICT1 MRPL14 CLPX MRPL15 DDX28 MRPS5 MRPL4 MRPL18 MRPS22 SORCS2

DAP3 MRPL57 LSM11 CSDC2 MRPL21 MCAT MRPL28 MRPL53 PTCD3 TIMM23 SLC7A1 MRPS2 MRPL37 TTC19 VCPIP1 MRPL46 MRPL17 MRPS17 GHITM MRPS30 GSTK1 MRPS7 MRPL19 PTP4A3

TSFM MRPL49 OXA1L MRPL27 RTN4IP1 MRPL33 TPGS1 D2HGDH MRPL40 MRPL48 LRPPRC MRPS9 MRPS21 MRPS31 KBTBD3 CHCHD1 MRPL3 MRPL55 PTRH1 C8orf82 MRPS18B GTPBP10 SLC4A8 GDPD1 MRPS27 MRPL47 MRPL50 ACADSB ACADVL MRPL39 NDUFAF7 MRPL24 SPCS2 CROT NRD1 MRPS24 SLC25A33 NDUFAF1 SKIV2L MRPL41 SLIRP ATP5SL MTPAP TRMT10C KBTBD2 RIMS4 NSUN4 MRPL16 FOXRED1 GRSF1 MRPL13 MRPS18A NKIRAS1 MRPL34 SYVN1 MRPL54 PMPCB MRPS6

NOMO2 POLRMT MRPS15 MRPL23 TTC37 TPGS2 QARS PMPCB DHX30 MRPS16 MTIF2 MRPL22 POLDIP2 TM9SF4 PLAT VARS2 CPNE9 ACAD9 ENDOG

DGKD PUS1 ERAL1 OCIAD2 AARS2 INPP5J ALDH1A3 GPAA1 TTLL1 FASTKD2 PYCR2 CECR5 OVCA2 NAT14 MTO1 ATP13A3

NSUN5 HAGHL SETD3

ABCD2 DDX3X ALPL

GLS2 CRH ECSIT GOLGA2 METTL17

MTFMT

DNAJC30

N4BP3

MRPL42 IVD KCNJ9 ABCB8 LRRC49 Module 7, n = 234, FDR Corrected pvalue 0.00044895

FUK MAP4 SELENBP1

GOLGA5

IP6K1

FBXO21 RAPGEF5 NUDT16 STX8 TMEM9 PAFAH1B2 HDHD1 AVEN

DNPH1 CIAO1 CARKD

ARHGAP23 HINT1 PSMA1 SLC4A3 MACROD1 SLC7A2 ABCG1 NT5C2 WDR45B KCNN1 COPRS PSMA2 PPP1R1A

TCF25 PEPD OTUD6B PPIAL4C OSBPL9 PTP4A2 TMSB10 UBC ADH5 UFC1 SCGN TFIP11 RGCC STARD10 SNX27 ACVR1 PYGB LPIN1 PITHD1 CALCOCO2

GLO1 GSTP1 BLVRA LRRFIP2 C10orf76 GNPDA1 ATP1B3 TPD52L2 RAE1 CCDC6 GRB2 SGSM2 RLTPR

IGFBP6 CYGB NELL2 SLC38A2 AMD1 KPNA4

MT1M ARR3 PHPT1 CRKL CA8 IGFBP5 CLCN3 CLU VSTM2A DKK3 RAB9A CRK PFKL GPI PRKAA1 MAP3K5 TPM1 PPCS TMEM43 HYI SRXN1 TIAM2 MT2A MTHFD1 SERINC1 UGP2 UBA1 PRKAB2 MAPK3 RAB6B PDCD4 DPYSL2 CYTH1 PTRHD1 MOB1B RPS6KA2 PTGR1 RBM4

MAPK1 CSNK1D ATG3 SORD MT1G SCRN1 AMPD2 SMAD4 TBC1D15 PDXK UPF1 PAFAH1B3 SEC22B ISYNA1 UPF2 RPS6KA5 PACSIN2 BACE1 ESD

TXNRD1 NDRG4 CHGA

EIF2B2 LTA4H GLRX BAHCC1 CMBL NHEJ1 ITGAV ART3 VCP NPEPPS FHL1 NPEPPS AK1 WDR82 NISCH

PRKCI GSTO1 MAP2K1 PIK3R2 CLSTN2 AAMP GPR56 ITGB8 AKR1A1 PEA15 PARK7 AKR1B1 FHL1 DGKG ARRB1 MAP2K6 RBKS STIM2 PSMA8 LGI4 PARK7 GNAQ MOB3A ATG9A HEBP2 ENO3 TMEM199 MPP7 ISOC1

SENP8 MT1X SESN1 SLC5A3 DST LCMT1 RPE NAGK NCDN

NAPEPLD EIF4E3 PSMA7 KCNN3

OPRK1 YES1 PKM CLIP1 MIF ANKRD18A ALDH3A2 BMPR1A SPAST PLXNB1 AKAP12 HSPA1B PRMT5 MOB2 PSMC4 CSTB B4GAT1 UBE2R2

PALM3 JAKMIP3 SLC39A12 R3HDM1 STARD7 SFT2D2 GAPDH ALDH9A1 MT1F TMEM245 MT1E CLDN10 ENO1 ENO1 GAPDH

NANS CORO1C SMYD5

MT1L PDE4DIP NUTF2

ARL3 ENO2 C10orf32 BPNT1 C1orf167

PDE4DIP

QPCT

PRKACB ELL3 CD93 Module 8, n = 232, FDR Corrected pvalue 0.30558

EI24 NKAIN3

CDC16

FGF12

TBCD

DIP2C RAB30 SEMA4G RASAL1 BRE FAM49B USP12 CPTP KCND1 UBE3C

NRBP2 DNAJC13 PPP6C SURF4 PDK2 ACTR2 EIF2B1 RAP1GDS1 TBC1D13 VDAC3 RAP1GDS1 HEATR5B VPS13A VPS8

UBR1 ATG2A KIAA0368 EXOC6B PTP4A1 RAB3B RAB5A JUP ERO1LB MON2 PIP5K1A USP46 ACOT7 VPS53 CERS4 FBXL18 KIFAP3 SLC25A22 CARM1 ITPR3 ATXN10 PLAA XPO7 TMEM11 NIT1 VAC14 VTA1 RAC3 VPS51 EIF3M SDHC STRIP2 ASPHD2

CSE1L PORCN UBE2D1 GRIN2D CDK5 CDK14 PPP2R1B PPP2CB COPS5 CTNND2 ADCY7 EXOC2 AP1G1 CRBN CYFIP2 ABCC10 MOB4 KPNA6 ATP2A2 RNF175 MAPK4 BZW2 NAPA MYO5B DYNLL2 ZER1 DNAJC6 DYNLT3 PPP2R1A SEC31A EXOC5 IPO5 COPS3 MGST3 RABGGTB PPP1CA LETMD1 DNM1L RHOB WNK2 PPP2R1A VPS35 RAP2C

USP9Y AP2A2 UBE2E1 RHOA AP1B1 KIAA1244 CUL3 TNPO3 TIMM22 TRAPPC5 RAC1 RANBP6 GPM6B MTMR6 UBE2D3 PPP2R5C TMEM167A ARFGEF2 EPHX4 HECTD4 RPS3 CTNNA2

PRPS1 ZNF728 CCDC132 MARC2 UBR4 RAB5C PRAF2 BCKDHB C16orf70 CAND1 USP9X GPS1 CDC42 AP2A1 SERINC3 PPP2R5D IPO7 TUBA3E TCP11L1 HUWE1 SULT4A1 DIRAS2 HMOX2 MTOR AP3D1 YWHAQ CUL2 ARFGEF1 RTN1 PITPNA RAB2B HUWE1 GPX4 RPS5 OSBPL5 AIMP2 HSPBP1 M6PR RHOC XPO1 ALDH1A2 TUBB2A FBXL20

HACE1 C1QL1 LDHC CCT4 TRAPPC6B ACTR10 ERI3 RTN4 FAM160B2 SRPK2 VKORC1L1 HPCAL4 ARMC8 CDIPT TMEM181 LY6H EXOC4 TRAPPC10 PRKD3 MTCH2 PAIP1 FAM49A MINOS1 EXOC1 OSBPL1A KCNIP1 TNPO2 GNAI2 KIAA1468 DMXL1 USMG5 LTN1 ATP6V0C TCEB1 0 VPS28 MIEF1 PRPSAP1 PTK2 ASNA1 MTMR9 UBE2O CISD2 MT-ND3 GNPAT CDIP1 ASIC2

RAB5B RER1 XPO5 KDELR1 C17orf75 TMEM33 EMC4 RAB4B UBE2Q1 CDC42BPA

PDCD6

DDX39B

FXYD7

RMND5A FXYD7 Module 9, n = 227, FDR Corrected pvalue 1

DOHH MZT1

UCHL5 MAN1B1

PMS2 FAM168A ABCD3 PLEKHG5 UCHL5 DDX25 EDC3 LPIN2

GNG11 MTCH1

AMFR PNMA1 PPP4R4 AP5M1 SLC27A1 WDTC1 PDE12 TUBGCP6 TMTC3 CHD5 CEBPZOS MLH1 FBXO45 ACP2

CHD3 C17orf49 DECR2 TTC21B PCDHGC5 OSGEPL1 MOAP1 NEU3 EXOSC1 ITCH DMWD FBXO3 PEX3 KCTD3 GCC2 COG5 ADCY3 COG3

MAPK8IP2 MIOS TPCN1 FBXO44 DGKQ KCNQ3 FADS2 NPRL3 WDR17 CREG2 ASNS LMF2 COG7 FUCA1

SDF4 POLR2E TECPR1 ARMC6 KIAA1279

FXR2 NUDT1 MINK1 C12orf29 TSTA3 PRPF40B GLG1 DCTPP1 RHBDD2 TARS2 SUMF2 PHYH TMX4 NENF PIK3C2A KIF1B NMNAT2 DNAJC17 KCNQ2 FAM3C PTPDC1 KNDC1 GPT2 PJA2 FAM127A KIF5A PRPF19 HDLBP PNCK IMPAD1 DUS2 FAM127B USP4 SEL1L PARN GSTA4 ENC1

DCAF8 TRIM27 ARHGEF4 KIAA0391

ETNPPL FDFT1 CYP51A1 NLN PSMG1 FBXO7 FGFR3 CIRBP TOP2B GPRASP1 YTHDF1 FKBP9 ZSCAN18 HERC4 STAT6 COG8

OCIAD1 HMGCS1 DPP8

SARAF RBM3 STAT2 SEC11C RHOBTB3 C16orf58 WDR54 RABL2A CLPTM1 CHCHD2 NUCB1 NEMF PISD HLTF FKBP8 MAGEE1 LONP2 OGFR TRUB1 RNF219 POLG QTRT1 CYP7B1 KLHL42 NAGA FKBP8 NTMT1 DCAKD NSDHL C20orf194 ERLEC1 GFPT2 CCS YTHDF2 GOLGA3 RARS2 BABAM1 GFPT1 PSME3 KIF1A GCC1 NRSN2

CASC4 TSC2 C21orf2 AES PPP1R12C GGA2 CPD RBFOX1 METTL9 HEXA GDAP2 SARDH MROH1 TXNDC12

FOXRED2 SCAPER ACBD7 INTS3 ZFPL1 NARS ACSBG1 NUDT4 NMT2 COG6 ELAC2 GTPBP1 FBXL17 MEST KIAA0319L FBXL2 CUL9 GBA

ACOX1 SNUPN SIL1 PEX16 UBL7 TM9SF2 MYBBP1A ENTPD6 MAP9 GOLGB1 LARP6 CWF19L1 CLIP3 PPP4C

CTTNBP2NL UBXN1

ALKBH7 MZT2A RUFY2 TUBGCP2

NOC2L RUFY2 VWF DPH1

TBPL1 MLF1

MDC1 TUBG2 Module 10, n = 200, FDR Corrected pvalue 1

ABCA5 AKAP6 TRIP12 MAP4K4 ARHGAP20 ATXN1

STARD3NL

CDH11

GALNT2

RNF214 CELSR2 ZNF483 SSX2IP HOOK3 HID1

MGEA5 HOOK3 APC2

MAST2 FKBP15 TRIM36

DENND6B TXNDC9 JPH4 CELF6 CDK16 HYOU1 ERBB4 TMEM135 KALRN CYP46A1

NEURL1 COA7 AKAP9 STAT4 RPS6KC1

HS6ST3 SPHKAP TTL NUDT4 LMTK2 BNIP3 PITPNM2 KLC2 JAKMIP2 PCM1

AATK JAKMIP1 OS9 LRRC4C UBASH3B ANKRD24 C6orf57

PPP1R37 PITPNC1 AZI2 MAP4K3 ARHGAP32 UBE4B TAOK2 RNMT DOCK4 ABR DCC ADRBK1 PPP2R5A ANKRD34A DIABLO ASAP2 ADCY2 SEC23IP ARHGEF2 CRELD2 PVR PPIP5K1

CAMK4 SH3RF3 RRM1 GBF1 DZIP3 R3HDM2 BCKDK HDAC5 OSBPL8 CLEC3B TRIM9 PGAP1 MPRIP IARS

CEP170B CDH22 DHRS7B DGKZ LSM12 IQSEC3 MTMR7 ASPH DOCK3 WBSCR17 PPP1CB RASGRF1 SORCS3 FAM73A PREX2 LARP1 MPRIP SLC4A7 FAM102A FLYWCH2 LMTK3 PPIP5K2 CKAP4 CAMKK2 ZNF512B FAM120A SERPINE2 NGEF MAST3 WBP2 ZC3H7B ARFGAP2 USP10 PTEN TM7SF2 HECTD1 KIAA1191 AFAP1 KLHL3 LYRM9 ADRBK2 FBXL16 CORO2B CELF3 DGKH FBXL16 STMN3 PCDH9 LRRC4B CHML DPM1 DNAL4 TESPA1 NUAK1 FRY LRTM2 TUSC3 GPR123

GRAMD4 NRIP3 SLC25A36 BCL2L2 PPP6R2 USP11 SIPA1L2

HDAC9 SNAP25 GAS7 WSB2 ZPR1 CSMD1 VPS13D DDA1 TIMM8B SPATS2L

NAV3 PCDHAC2 FARSA MYO1B TBK1 MYCBP2 FAM103A1 TTC5 CAMK1G NAT8L ACAP3 DPM3 CYB5R1 KAZN PPP2R5B

ANKMY2 SLC4A10 NDRG2

MAP7D1 PJA1 SLC4A10

AMOT SEC24C NDRG2 TECPR2 CDK17 SNX14

MAGED1

SNX13

MFF

MPPED2 RAPGEF1 GRASP CELF1 FBXW9 PDE4A Module 11, n = 198, FDR Corrected pvalue 0.094128

FEZ2 SUCLG2 ADH1B HIP1R PTGR2

FGF2

ADAM17

MEN1

VWA5A RAB13 AKR7A2 METTL7B

FYCO1 EML3 SLC39A12

PLSCR4 SPARC S100A1

LSP1 MTAP MSI1

SMAD5 KANK1 PXN FLNC MTAP FABP7 GNA12 TSPO KIF13B ZAK IMPDH2 KRT79 TRADD SLC6A9

ALAD PSMD10 PALLD ITPR2 VIM PSMD9 ZC3HAV1 PALLD ITGA7 CRYL1

ABHD14B CAPG TRIP6 ANKFY1 LIN7C HNMT ICAM1

PSAT1 BBS2 PGGT1B ITGB1 LGALS3 PRKG1 S100B GNA13 GYG2 ROCK1 SEC14L2 PADI2 ABLIM1 CD109

ARHGEF40 NHLRC2 NEK7 ITGB1 PLEC PRKG1 PI16 UTRN

LOC728763 FAH PSMB9 PLEC MAPRE1 MSN LIMS1 ENTPD2 PRDX1 GSTP1 HSPB8 PLIN3 PTBP1 BBOX1 ITPKB MYD88 FAH SNAP23 HSPB1 CAPN2 ERBB2IP PGM2 SEPT2 CSRP1 SH3BGRL CD44 STAT3 PHGDH PNP TJP2 GMPR GNG12 SHMT1 RFTN2 CSRP1 PRDX4 PSMB8 DDAH2 PDLIM5 ANO6 PTER PLCD1 PTTG1IP DNAH2 NUDCD2 DBI CAPS PLXDC2

ANXA4 ELP4 LLGL1 MPST CD2AP PGAM2 EPPK1 PARVA OPLAH PLP2 S100A6

CDH20 PFN2 PBXIP1 PRDX6 PGLS CD99 NUB1 GFAP CDKN2C MTM1 ASPH LHPP COTL1

ITGB4 GFAP ANP32B MAOB ARAP1 ANXA1 PLCD3

CPNE3 NECAP2 ATP11A ILK GFAP IDH1 KIF13A HEPACAM FAM114A1 WASH6P

CD58 EZR TMX1 C4B LAMA1 CSK EEF1A1 SCRIB SSFA2 TAX1BP3 PHYHD1 GALK1 CBFB TRIM56

SDC2 PDLIM4 FABP5

CBFB ITGA6 NPEPL1

BTN3A2 HVCN1 GYG1 CNN2 MTSS1 RNF114 TRIM25

PGPEP1

CLNS1A

SYTL4

PHYKPL SRR NT5C EPHX1 DNPEP Module 12, n = 164, FDR Corrected pvalue 1

PAWR

ARHGEF26

CLCC1 IFT43 SH3GLB2 SLC14A1 NEB TMEM192

JAK1 MAP4K4

FRMD8 NHS

PHIP C9orf142 NES ARHGEF4 FYN DDX19B TSC22D4 EFNB1 NFIA

HMGN5 CLASP2 STOM RUFY1

FAM21C RHBDF1 RGS20 MCC PDZD11 UBXN4 MLC1 SNTA1

MAPKAPK2 PDLIM3 LAMTOR1 PKN1 TNIK PCDHGB6 SLC4A5

CLASP1 TNIK IGSF11 CGNL1 LPP TOM1L2 FXYD1 ADIRF TWF1 AQP4 TNIK CD99

PAIP2 TNS3 PPAP2B TP53BP2 TPD52L1 SZRD1 DDX19A ABLIM3

PLEKHF2 NEBL WASF3 SLC44A2 CDC42EP4 CCDC50 UPF3A GPRC5B BAG3 DTNA G3BP1 CMTM4

SORBS1 PARD3 TTYH1 PPP1R1B YAP1 MAP4 TNS2 DTNA ADD1 IMPACT ABLIM1 SLC1A3 SORBS1 TXNIP DTNB MAVS AHNAK CARHSP1 APPL2 DTNA EPB41L2 PLEC MTSS1L FAM107A HEPACAM SLC7A11 ADD3 STON2 CTNND2 PLEKHA7 EPB41L2 SLC4A4 PLEKHO2 ADD3 PHKA1 EPB41L5 MRVI1 CNN3 EPB41L2 STON2 GJA1

NEK9 CSPG5 TJP2 SDC3 NHSL1 EPB41L2 C1orf122 NBN SNTB1 ACBD5 TMBIM6

ARPIN MAGED2 LIMA1 LRRC16A NCAM1 TJP1 FAM120C

ATP2B4 GRAMD3 LIMA1 PVRL2 C2orf72 SNTB2 TUBB2B DMD

PRKCA RELL1 PMVK PLXNB2 SYNM RLBP1 FARP1 PHKG1 WDR91 PPP1R3D PLEKHO1 SORBS3 MARCKSL1

CCDC93 RHOC

VAMP5 NEO1

CBS TOR1AIP1 PHACTR4 SCAMP2 TMEM51 PEX19

ALDH1L1

STAM2 Module 13, n = 162, FDR Corrected pvalue 1.1211e-05

PHF5A

TMEM209

AGO2 UBXN7 LSM4

NHP2 SRSF2

DDX18 RPRD1A HIST3H2BB

GTF2F2 TCEAL4

TMEM87A NPM1 TRA2A THOC2 NUP98 HNRNPM DCPS HNRNPM

ADNP PRPF40A HNRNPM XRN2

SRSF8 SNRPF CACNA2D2 NFIB PTBP2 SNRPD3 SRP9 RBM25 HDGFRP3

THUMPD1 TRA2B NIF3L1 HIST2H2AB RNF20 DDX39A

HMGB2

PABPN1 HDGF HMGA1 USP39 PRKDC HNRNPR HNRNPA1 SNRNP70 HMGB1 HDGF

UBA2 PRPF31 LSM7 HNRNPUL1 U2AF2 PRPF8 RBM12 SF3B6 APEX1 SNRPD2 EFTUD2 ILF2 RNPS1 SNRNP200 CENPV METTL14 XRCC5 XRCC6 API5 NUDT21 SRSF6

SNRPA SRRM1 FTO HNRNPUL2 SMARCC2 SAP18 RPA3 SAE1 SET SIN3A HNRNPU CCAR1 TRIM28 RPA2 HNRNPC HNRNPA3 ILF3 SNRNP40 SF3B3 THYN1 FAM98B SF3A3 H2AFY SP100 SF3B1 NOP58 CBX3 WBP4 NCL RPA1 H2AFY2 EIF4A3 SSB TARDBP SMARCA5 CHD4 TPR MTA2 RUVBL2 ANP32A SUN1

HIST2H2BF HNRNPH1 LMNB2 DDX23 SRSF3 ERH DKC1 CSTF3 HNRNPLL KHDRBS3 TCERG1

PUF60 NOP56 LMNB1 H1FX HP1BP3 SNRPB RALY CBX1 HMGN2 NFIX CTNNBL1 PHC2 POLR2A EWSR1 PSIP1

SMU1 MAGOH SNRPG DDX39B NUP93 PTMA U2AF1 HDAC2 GNG10 FBL GTF2I HDAC1

SART3 NUP54

NHP2L1 SART3 RNF2

CHAMP1 RBBP4 SF3B4 RBBP4 NUP133

MBNL2

RPRD1B Module 14, n = 162, FDR Corrected pvalue 4.448e-14

VPS13C

TBCC

TACC2 TUBAL3 TTN

EPB41L3 GUCY1B3

PFDN2 FKBP1A TPPP

CALML3 PLCG1

CHM VSNL1 PANK1 APBA2 ACYP1 DSTN HINT3 CCDC43

CAMK1 STK38L MAPRE2 EFHD2

TACC1 GLMN ATG2B ARPC5 RAP1GAP NAP1L4 ATP2C1 DPYSL5 SCYL1

UBE2N PPP1R7 PROSC UBE2O PCMT1 PPP5C

COPS6 SAR1A PDCD5 SRCIN1 CAB39L ADAP1 ARHGDIA GMFB CCT2 USP14 PFDN1

DCTN3 SUMO3 RAD23B OTUB1 PTPN11 DYNC1I1 PANK2 TPI1 STAM

USP15 PGK1 CUL5 RAB8A SYNJ1 WDR44 TXN CCT6A CCT5 DYNC1LI1 AP1M2 TRAPPC3

DNAJA2 KPNA3 PGAM4 TCP1 VBP1 TMEM189-UBE2V1 DYNLRB2 NAPG ATG5 RDH11 CCT8 FSD1 CAPZB TCEB2 HSPA4 AP1S1 COPS4 PSMB5 PFDN6 PPP2R2D UBE2V2 KPNB1 DUSP3 CCT7 NAPB HSPH1 MTMR2 LDHA OLA1 RABEP1 NME1 PPME1 RASA1 RALA HAGH UBE2K CHMP3 LDHA CKAP5 CUL4A

CAP1 UBE2M CCT3 CCT3 PGAM1 PFDN5 BCAP31 PPP2R4 PFN2 SGTA LRSAM1

RABGEF1 FABP3 RAB8B AP3M1 GSPT1 SACM1L

RAD23A PFKP MAP1LC3A TMOD2 PDCD6IP NAPA PFDN4 NPLOC4 DYNLRB1

AKT3 PSMA6 WDR45 COPS2 RAB7A DCTN5 MAT2B PSMA3 PRKAR1B TUBB3 CFL1 CAMK2B

SMARCE1 CAMK2B

RABGAP1 SLC6A15 ACOT7

PPP2R2A DDAH1 EHD4 UBFD1 PSMB7

TUBA8

VPS4A Module 15, n = 158, FDR Corrected pvalue 0.15687

FAM131B

MAOA GALNT16 SLC27A2

RUNDC3A RUNDC3B

TFAP4 PTPN23 SPRYD7

STK11 RGS14

NFAT5 FAIM2 PRKAA2 RGS14 PRUNE NUDT11 DPYSL3 CUL4B

ME1 NRSN1 SEMA4A GPD1L

PRKACB PRNP LIME1 CETN2 PRKAG1 RAB33A GPC4 GABRA3

CCK GRM1 YWHAE PLEKHA1 PTPRK PDE1B ACOT9

COPS7B SCAMP3 TRIM3 PRKACB ADCYAP1R1 WIPI2 SGSM1 HTR1A CACNA1B TMEM63C DIAPH1 MB21D2 SNX12 C16orf45 VPS26A CIT VPS16 LYSMD2 AMPH SCG5 C16orf45 LMBRD2 CORO1C TMEM30A LSAMP TRAPPC9 PTPRN2 ATP8A1 TPRG1L NPDC1 ABI1

SLC2A13 SYN2 CACNB1 PCSK2 SCG5 ATP8A2 PALM PDPK1 UPF3B SMG1 ATP8A1 ACTR3 NCOA7 SIDT1 RAB27B SYN3 NPTX1 PKM GABARAPL2 VAT1L RAB24 MFSD4 DNAJB2 SCG3 CPE DNAJB6 NSFL1C SLC7A3 CPE SLC7A14 UCHL1 WDR1 SBF1 SCG2 VIPAS39 MTMR12 ANK2 MTURN LCK STXBP5

RAB10 ANK2 PAM DGKA EPB41L1 FLOT2 ARL6 OPTN EHD1 RAB27A FLOT2

CAMK2D CAMK1D USP5 SLC6A7 NDRG4 PRKAG2 PKIA

VTI1A TIMP2 OPHN1 SNAP47 RGS17 CYB561 AIDA SLC9A6

MFSD6 FLOT1 RAB3D GMFG GLOD4 ATP6AP2 MTMR1 OCRL MFSD6 GAK TUBB4B CNKSR2

TUBB CAMK2B

GABARAPL1 BTN3A3 SPIRE1

RAB1B KSR2 LRRTM2 RAB4A PDE1A

CAMK1D Module 16, n = 154, FDR Corrected pvalue 1

SRP68

AKT1S1 GORASP2 COBL

ADD1 COBL

SMNDC1 ZNF706

EIF4EBP2 TMEM55A

CCDC23 MXRA7 YIPF4 SERPINB9 LAMTOR5 EPS15L1 TNRC6B ERVK13-1

STIM1 C19orf66 SYNCRIP MAP4

TAGLN3 PHACTR3

THEMIS PRRC2A MAP4 EIF3G HN1 INIP

CHTF8 SYNRG UBAP2 PKIG MAP4 MAP2

TAF15

TMEM57 ZFR BOD1 TMEM41B SPAG9 RPS10 ARPP19 CAMK2N1 ALYREF LSM14B

FAM192A

TSC22D4 G3BP2 PCNP WIBG SKP1 LSM14B SERPINB1

TCOF1 G3BP2 BTF3 CWC27 UBAP2L CCNT2 COPZ1 C11orf58 MTDH NACA2 TSC22D1 POM121C

NUFIP2 SMIM13 GPALPP1 ATXN2L RBMXL1 SNRPC HYPK RPL26L1 PRRC2B C14orf142 SERBP1 NRGN PRRC2C MAP7D2 ZRANB2 HOPX LSM14A PAG1 MAP7D1 SERPINB6

WIPF2 CWC15 SRRM2 RBMX PPP1R2 TCF20 CDV3 MAPT HABP4 CSTF2 SCAF4 ATXN2

FAM195B PDAP1 C18orf25 SET POLDIP3 ATCAY KIAA1211

NUP50

SEC16A SAFB2 NMT1 C19orf43 ATXN2 SPECC1 NACAD CNBP RANBP3 SF1

AKAP1

POLR2M TMEM230 C1orf21 PNMAL1 NUP153 NTRK2

MAP9 CREB5 GKAP1

JUN UFD1L SCAF8

ZFAND5 0

EBAG9 ATOX1 0 TSPYL5 ATF2 LARP4B

ZC3H4 EIF4B NUP35 SS18L1 TNKS1BP1 FMR1

BAG4 FMR1

SMIM20 CASC3

PICALM CRK

STMN1 RPS27A PACSIN2

SHROOM2 Module 17, n = 153, FDR Corrected pvalue 1

BMS1 ZNHIT2 ZMYM3

GTPBP4 RABEPK

MTR DSCR3

HEPH PCDHGB7

PBLD GTF3C5 MVK AQR BCL10 AS3MT TRIM65 DEPDC5

SEMA4B RNGTT GIMAP8 WWOX

PBRM1 MORC2

CUX1 GNS APOA4 FAM98C EIF2A PCDHGC3

CUL7 TRIM4 METTL3 TBC1D19 NPRL2 NUDT12

GOLIM4

LGMN PDCD11 GHDC UNC119 CD2BP2 PLXNB3 OBSL1 CMTR1

GALK2 GTF3C1

PNKP

AP5S1 PARP10 WDR35 SPTLC1 LRP4 ANKRD35 UTP14A

HPS6

SMCHD1 SCP2 SEC14L1 PRPF6 FCHO2 DDX56 LRIG1 GCN1L1 H6PD

IPO13 NELFB

C4orf27 FUT8 TRMT2A ANKRD39 COLEC12 SSH3 PIK3C2B NELFA

AASS WDR19 POLR2B SPG11 GLB1

FAR1 SNX29 TRIP11 STAT5A ARMCX1 GOLGA4 IRF9 CLN5

CLGN POLR2J

IFT122 TRMT5 SCARA3 IFT140 TRAF6 UBL5 POLR2C DENND3 GTF3C3

PLXNB2

USP48 SCD HMCES POLR2L OGFOD2 DENND4C HECW1

EMG1

TRMT6 NOL6 FKBP10 FEN1 EXOSC10 PCID2 TMA16 SNRPD1 ZEB2 LRRC41

FBXW5

ADCK4 PCYT1A RNF181 ZNF687 MTG1 MAD1L1

DHX38 RNASEL USP13

EXOSC9 BAZ1B CYP27A1

CSPG4 ZNFX1

DNASE2 UNG RRP1 RFC2

DENND5A HEATR6 UBR5 THUMPD3 TELO2 HLA-E PLD2 TRIM33

DICER1 THOC1

WDR18 SZT2

NELFCD HDAC6

SAP130 METTL13 CTDP1 Module 18, n = 148, FDR Corrected pvalue 0.074783

PRCC SMEK1 BRD4 MEF2C SAMD12

TCF4

DCP1A

KIAA0415

RBM15B

SPIN1 KIAA1143 JUND CCDC12 NCOR2 HMGN3 EIF4ENIF1 RSF1

PUM1 GATAD2A ARID1A

RBM15 MATR3 GPKOW

ZC3HC1 SH3KBP1 MATR3 DDX6 NOVA2

SPAG7 CHTOP SART1 ZNF787 HNRNPA0 BCL7A

SMARCA4

YLPM1 PNN NCOR1

MTA1 TMPO FUS TTC33 HCFC1 CPSF7 GNG5

SNRPB2 SNRPA1 IRF2BP1 PRPF3 TCEAL5 MYEF2 CDK9 TMPO SF3A1 SNW1 MAP7 CCAR2 DAZAP1 MYEF2 PSIP1 MECP2 PTPLB TP53BP1 KHDRBS1 ELAVL1 GATAD2B

PSPC1 SYMPK SLTM LIMCH1 SF3B2

CIC FYTTD1 NOLC1 KHSRP FUBP1 ENY2

CDC5L

HNRNPAB LEMD3 CHERP HNRNPL

PLRG1 CREB1 HNRNPD SAFB TCEB3 THRAP3 NONO HMGA1 HNRNPK NELFE GTF2F1 FAM169A HDGFRP2 SMARCA2 SRSF11 DDX42 RBM17 LMNA DR1 WBP11 FOXK1

HMGN4 ACIN1 BCLAF1 PPP4R2 ACIN1 SF3A2 SORBS2

RBM26 TSC22D3 SRP14

PQBP1

FOXO3 IK SCAF1 HNRNPU RTF1 RBM12B U2SURP SFPQ SON HECA CPSF6

TCEAL1 RPRD2 TCEAL2

PPIG FIP1L1 KHDRBS2

HMGN1 TCEA2 PHF20L1 POGZ RBM10 MFAP1 NUP214 MEF2D

PNISR

PPP1R12B

DCP1B

PPP1R12B

PHF14 C11orf31 FBLL1 TBR1 SMARCC2 Module 19, n = 142, FDR Corrected pvalue 1

NAB2 DENND5B SSH1 CACHD1

MAP3K12

ARHGAP10

ACAP2

FAM84A

WLS FAM63B METAP1 PDZRN3 ATG101 ATP11B SLC41A3 TTC9C ENTHD2 CSNK1E

EVI5 EIF1AD SEMA4F

CHRD SLC9B2

YOD1 IKBKG LGALS8 AP4S1 PCDH17 TACC1 B4GALNT1 SH3PXD2A LSG1

STMN4

FZD8 UBE2F LPHN3

SLC9A7 CCDC28A STX6 FSD1L FGFR1OP2 ARPP21 DAGLB

ZFYVE1 TBC1D23 TNKS MEMO1 DGKB

KCNH1

FOCAD CERS6 ACVR1B CCM2 RIC8B CACNA1B RIT2 BMPR2

ANO3 TAX1BP1

GUCY1A3 BAG2 PHACTR2 UAP1

C9orf16 CHMP7 TRAF7 USP19 SPG20

NF2 KPNA1 USP15 SOGA3 PIK3R1 CTGF

CC2D1A MCF2L GTDC1 STX16 MIB1

TTC4 ARL10 KIAA1109 ATG16L1

DNAJB1 IPO9 CD46 PTPLAD1 DNAJC12 DPAGT1 KCMF1 SCYL2 HSPA7 FAM13A

TAF7

DNAJB1 RAB26 SPECC1L MCF2L2 ALS2

AJAP1 TMEM132A PI4K2A CIT FAM160B1 TAPT1 KCTD10

GPATCH2 RAB39A DTNBP1

SEZ6L2

BNIP1 GOLPH3L ROBO1 RTN4R MEGF9 SLC29A1 LRP11 MAPT RIC3

EXD2 IRS1

GABRA4 DNAJA4 DNAJC5B

DUSP19 CDYL2 PEX11B ZDHHC14 MTCL1 NME7 CNTN4 RNF123 ISLR2 TMEM151B

TRAF3

RNF34

ZNF800

TGOLN2

SYBU GDPD5 UBQLN4 KIF21B Module 20, n = 141, FDR Corrected pvalue 0.19461

NOP2 USF1 NOP9

DTYMK RBBP6

HIRIP3 GLYR1

SQSTM1 RBM33 HNRNPK ZC3H14 ZNF326 PRPF4 C1orf52 RFC1

NUP88 DNMT1 TSR3 FAM21C

TCEAL3 CCDC124

HEXIM1

AFF4 PPIL4 DNAJB6 RAD21 WRNIP1

RSRC2 NCBP2 SLC4A1AP DDX1

PPIL2

RAVER1 TCEAL7 TMPO NOSIP

ILKAP RBM22 DEK AKAP8L TERF2IP ZC3H18

RBM14 PRPF38B ARID1B CDKN1B TMPO CGGBP1

SUPT5H

RBM8A ZMAT2 SMC1A SREK1 RBM4B YAF2 DDX17 LSM6 POLR2G SRRT

HNRNPH3 DHX9 ARGLU1 CCSAP

C7orf55-LUC7L2 MBNL1 BUB3 LUC7L3

C9orf78 NASP EDF1 LUC7L PRPF4B TMA7 CDKN2AIP

HNRNPA2B1 TSPYL4 NCOA5 DHX15

CCDC9 TCEA1 ZNF638 CFDP1 CBX5 SON AGO1 PDS5B ARL6IP4 RBBP7 PHF6 DDX46 SRSF4 DNAJC8

FAM50A TOP1 PAPOLA PAK2 RNF40 HTATSF1 SAFB2

HMGN5 RBM39 RANBP2 RGPD1 NXF1 TERF2

SERF2 FMN1 H2AFY ZC3H11A

NCBP1

RCC1 UBE2I SRSF1 GPATCH11

BUD31 C14orf166 PIN4 MORF4L2 UBR7

NUP62

0 SRSF10

C19orf53 KIAA0907 CXorf56 SRSF7

SRSF12 GTF2B RALYL NUBP1 RCC2 ARFGAP3 SAP30BP THOC5

SEPHS1 CDC73

SPEN SNRNP27

SASH1 WDR5 RUVBL1 Module 21, n = 126, FDR Corrected pvalue 1

IFIT2 HLA-DRB1

PTPN12

FMNL1

ASCC3

HMOX1 PLCG2 FAM129B PSME2 FOLR2 OAS3 TAP2

PSME1 CHI3L1

DDX58 F11R PPP1R18

KCTD12

TRIM47 GBP1 SQRDL LRRFIP1

ITGAX NCF1B PLTP TLN1

IFIT1 CTSZ

CPVL PML

FCGR1A VASP ARPC1B FCER1G ITGB2 PAPSS2 SIPA1

CYBB ITGB2 SPP1 GBP2

HLA-DPA1

P4HA1 SAMHD1 TYMP TBXAS1 CYBA CD14 TRIM21 PTPRC CLIC1

ARHGDIB PSMB10 APBB1IP HLA-B ABI3

C1QB GIMAP4 MNDA LCP1

HLA-DRA PTGS1 PTPN6 S100A11 RNASET2 RIPK1

SCIN PDLIM1 IFI30 IFI16

LPCAT2 SYK CD74 STAB1 YBX3 C1QC NCKAP1L PECAM1 FERMT3 GIMAP1 CD163 PYCARD PALD1 PARP9

IQGAP2 SERPINH1 RAB32 HCLS1 B2M

WASF2 VASN AIF1 LGALS9 C1QA INPP5D ITGAM

ALOX5AP CLIC2

LYVE1 TGM2

FAM129A FCGBP DOCK2 TAP1

F13A1 NPL CASP1 MYO1F

SASH3

CTSC MAN2B1 TMEM119

ALOX5 RNF213

PYGL IL16 HLA-A UBA7 MYH9 IQGAP3 PLEK

SCPEP1

TMEM173

BST2

IFIT3 STK10 Module 22, n = 118, FDR Corrected pvalue 1

FAM219A

FAM47E-STBD1

FAM110B

GPRIN3 C12orf45 WASL KLC1 MLF2 EXOG VTI1B

MMGT1 TP53I11

FAM134A SPEG APC

SGK223

MTFR1L OSBPL8 CAMSAP2

DACT3 DCX SAMD14 SORBS2 CAMK2N2

EIF4G1

C12orf73 SLC1A2

COX19 GRIN2A SIPA1L1 ARHGAP32 PIANP AHCYL2 SMAP1

SORBS1 GRIN1 AGFG1 TOMM5

VAPB

REEP1 GPHN KIAA1462 SNCB MAP2 SYNPO ABLIM2 PPP1R9B MAP2

PPP1R9A KIAA1107 EPS15L1 SATB2

LZTS3 SYNPO MAPRE3 LPPR4

HMGB3 GRIA4 AAK1 CTTN PRRT1 LMO7

MLIP BSCL2 JPH3 BAI1

LMO7 TOMM20 CDKL5 ENSA SHANK3 CASKIN1 VMA21 ABLIM2 SHANK1 TUB PPP1R12A RTN3 CRIP2

STK25 SMAP2 BABAM1 REEP2 PRKRA

GRM5 EIF4G3 MINK1 MLLT4 C9orf172 CCNY SUGP2

KCNB1 PLEKHA6

PCP4L1

DAB2IP ABLIM2 KCNJ3 DMTN BAALC

ADD2 DLGAP4 CLINT1

DBNL

TANC2 KCNJ6 DBNL

TANC2 ZC2HC1A

DCLK2 PRR7 DCLK2 CAMKK2 ARHGAP33 WNK2 ABLIM2

KCTD8

MARK3

SDAD1 Module 23, n = 111, FDR Corrected pvalue 1

WHAMM ARFIP1

EPHB1 LAGE3 ZNF223 ZNF428 CHRM3 STUB1

PENK PAK4

PPM1K LIME1

CPNE6

GREM2 FAM19A2 ATE1 NHSL2 ARFIP1

DIP2C PPFIA1 HS6ST1 PLEKHA5

F8A3

REPS2 SEPT9

UBXN10 KIAA1671 MPP2 TOM1 TCEAL6 TPM3

MBP WFS1 CDS2 RBSN

JMY

KBTBD11 EPB41L1 CYTH3 SUSD5 CHGB CXCL14 AKAP7

MICAL3

CEP170 KCND3 RIN1 AGFG2

CNST CSNK1A1 AP3S2 CCDC177

GRIP1 ARHGEF7 PPFIA4 MKL2 NRP2 THAP4 AGAP1

MARCKS

TAC3

EHBP1 CABLES1

CDH4 ERICH5 ARVCF CRTC1

PTPRT

ARHGAP21 CNNM3 CARTPT SOWAHA PTMS TMEM56 SHISA9

RALYL

BCAR3 GNAS PRRT2 GNA11

AKAP10 MAP1S FAM117B

PEX14 DAPK1 GNAS

FRMD4A RAB22A

UNK

JPH1 FAM114A2 SLC24A4 PAK6

TMEM74B SYT13 DIXDC1 RABL6 PPM1J

IGSF3

GSG1L CAMKK1

TMOD3 FBXO31

SLC44A2 ANKS1B TBC1D1 TYRO3 THSD7A ARHGAP39

TMEM25 UBL4A Module 24, n = 111, FDR Corrected pvalue 1

TGFBR1 TMEM2

ZZEF1 POLR2K ZZEF1 XPR1 LRRC8D RHOJ

CPSF1 CDA

FBXL15 MAT1A

RNF14

SLC2A6 WDFY3 EFTUD1 UROD RGL2

LRBA CLCN5 PPP1CC GLUL

ADRA2A

GLRB MPP3

LRRC8C TCAF1 VPS39 HECTD3 KSR1 MEF2BNB-MEF2B

RABIF MAN2A2 COPS8 LONRF2

CLSTN3

SNX17 RASGRP2 DDHD2

GMPPA PKM PTGES SEMA7A

MAST1

VPS18 CLCN7 TMEM127 EMC1

PSMB6 AGTPBP1 ZC3H7A

HERC2

PANK4 FGF14 ARG2 ABCC5 EMC2 SOGA1 MATK

MIB2

PNPLA6

WDR77 GOT1

CDK18 PIK3CD ATRNL1 ADCY9

UBR2

PGP MSRA NGLY1 DIP2A CAD DAPK3 RABEP2

HSPA14

CUL1 TRIM26 PELO VPS41

ACOT8 ABCA3 CLCN4

NEURL4 GMPPB NACC2

SLC25A29 CAPN7

EEPD1

PWP1 USP31 SELO KCNJ10

RCHY1 MAP2K3 POTEKP PSMB1 SLC22A17

CDC27

PCYT1B NUDT8

EIF2B5 ULK1

CCDC129 PIP5KL1 TUBB3 GALT GRIP2 PPP1R3E

PTPRE TRIP10 Module 25, n = 104, FDR Corrected pvalue 0.012325

STK38

KCNA3 RNPEP METAP2 RBBP9 DPP9 BLOC1S1

MPI UBA3

ADK

HDHD2

C18orf8

HBS1L DAK TUBB4A

AASDHPPT AIP PGK2 NRIP2

AGO3

ATG4B RANGAP1

DRG2 MAT2A ACSS2 GARS ETF1 G6PD

UBA6 RABGGTA ACAT2 PCYT2

G6PD

C6orf211 GDI2 FASN

MDH1 RUFY3 UBE4A hCG_1789329

AHCY

TXNL1 EEF1A2 APPL1 DOCK9

GGPS1 NIF3L1 DCTN2

GRHPR

BLMH UFM1 CAPN1 DYNC1H1 RAB6A SPR

NUDT5

PPIA

KIAA0196 ACTR1A

URB2 CAPNS1 DYNC1LI2 DCTN4

TRIM2

DCTN1 FBXO2 PGD PSMB3

GLRX3 IMPA1 PPIA

CLIP2

DCUN1D1 CMPK1 TARS GAPVD1

RIN2 MAP2K2 RWDD1

SARS NDRG3 ADPRHL2

KIAA1033 APP

NAP1L1

IST1 PIK3CB TKT ADSS

LDHB BOLA2 SNX6

VPS4B

EIF2B3 PTGDS

SNX1 GCLM

LYPLA2 LGALS1 PEBP1 AKR1B15 PRDX2 INPP1

RAB29 Module 26, n = 97, FDR Corrected pvalue 1

THBS1 EPB41 SAA1 APOL1

RPIA HRG

BLVRB HBE1

AGT CA3

AZGP1 ENG TF C4A APCS

SPTB CRP

LRG1 PON1

LPA AFM ORM2 SERPING1 SERPINF2

C1S HPR

SAA2-SAA4 TTR SERPINC1 C8G

CFI FGA

TTC26 AHSG

ORM1 C5 C3 HP

HPX A2M CFH PLG SUPT6H ANK1

ALB CFHR2 CP C9 KNG1 C4BPA ITIH1 APOB PF4

PPBP LBP 0 F2 C6 GC

SERPINA1 ITIH4 A1BG APOB

SPTA1 SAA2 PROS1 GC

SERPINA3 FGB APOH FN1

VTN ITIH3

C8A FGG FGG SLC4A1 APOC1

C1R C2

APOA1 APOA2

ITIH2 SERPIND1 HBD APOC4-APOC2 AMBP

BPGM APOC3

HBA2 EPB42

HBB S100A4

CST7 C7 CA1 CAT Module 27, n = 93, FDR Corrected pvalue 1

EMILIN1 RRAS

LAMC3 CES1

GGT5 PDLIM7

EPS8 PDLIM7

MMRN2 CAV2

LMOD1

ANXA2 KANK2

MYL6 TPM1

TAGLN2 SMTN

FBLN2 TPM1

PRKCDBP BGN COL6A6

VCL TGFBI ITGA1 TPM1

COL6A3 COL2A1

ENTPD1 COL6A3 CAV1 RSU1

LAMB2 COL5A2 COL6A1 NID2

COL14A1 NID1 DDN COL6A2 BGN TINAGL1

LPP LAMC1 SHOX2 AOC3 FLNA COL1A2 EHD2 TNXB LAMB1

COL1A1 PRELP ITIH5 FBN1 CALD1 AGRN

CNN1 DCN PTRF MFAP2

CRIP1 COL23A1 COL12A1 MYL9

MYH11 OGN

CSRP2 BCAM MYO1C COL18A1

LAMA5 HSPG2 TAGLN

COL4A1 TNS1

TPM2 FMOD

PGM5 TNS1

TPM2 LUM

FLNB

VWA1 SORBS2

COL4A2 LAMA2

AEBP1 S100A10

LAMA4 MYOF

MFGE8 TGFB1I1 Module 28, n = 86, FDR Corrected pvalue 3.9464e-06

NUCB2 PIGU EIF3H

DCK

RPS24

RPS13

ACBD3

PQLC1

EIF3K

RPS27 ABCE1 STRAP

COG2

AIMP1 BTF3L4 TMEM214

COPE RPLP2

RPL23A CSDE1

RPL35A RPL37A EIF3A

RPL3 RPS14

CFAP20

RPS25 ELAVL2

COG1

RPS28 RPS3A RPS11 RPS27L

MSMO1

RPL9 RPS19 GNB2L1 RPL26

RPL14

RPS23 RPL22 RPL23 RPS12 RPS3 RPL11 RPL12 NACA

SRP72

RPLP0 RPS2 RPL21 RPS17L

EIF3I

RPL38 RPS16 RPL10A RPS20

NAP1L5

RPL5 RPS4X

ELAVL3

RPS7 RPL30

RPLP1 RPS4Y1 RPL31

CAPRIN1 RPS8

RPL17 RPS21

SSR1 LARS RPSA

RBFOX1

YTHDF3 TM9SF3 LRPAP1

SORL1

EIF3C

ERGIC2

SIK3

RPS26

ARL1

PAPSS1 FAU RPL7A Module 29, n = 81, FDR Corrected pvalue 0.010991

PTRH2 CERS1

XPNPEP3 OSBP2

CDK5RAP3 PBDC1

CCDC91 PHYHIPL PUM2

GANAB NAA10

TMED4 DDOST GOSR1 EEF1G

EIF1

DNAJC3 ACTN4

EEF1E1 SCFD1

MSI2 SRPK2 ACTN4 MAP7D2

EIF4G1 STT3B

P4HB UGGT1 EIF3J MIA3

DRAP1 TPM3

MAP1B SCN2B LRRC59 RTN4

SESTD1 TMED10 MLEC PABPC4 DNAJB11 KIAA1715 FXR1 HARS RSL1D1

SGTB CANX SRPRB SEC13

COG4 MBOAT2

ST13P4 SEP15 MANF KLC1

LMAN2 C18orf32

CARS PDIA3 RPN2 MXRA7

PDIA4 PRKCSH

PPIB EPRS

CLASP2

EIF1AX DNAJC10 HSD17B12 TICAM2

GOLGA7B WARS

ZW10 SRPR RMDN3

LIMCH1 PICALM

CALU SLC39A7

CALU AGPAT3 Module 30, n = 73, FDR Corrected pvalue 0.0016322

SCARB2 SERPINI1

ATIC TMED2

COMMD9 PSMC1 CLINT1

ACTA2 EIF5A2

HSBP1 EMC8

EIF3F PSMC1

PCBP2

TPT1 SLCO1B1

ST13 PPIL1

PSMD4 PSMC6

PSMA4 PRMT1 OSBPL2 NAE1

C1QBP PSMD11 PSMC3 GPR125

ADRM1 RANBP1 PSMD2 GDI1

TMED5 PRPS2 BCAP29 PSMD13 PSMD1 YWHAE DDB1 CMAS TUBB3

PSMC5 PSMD12 PSMD6 XPNPEP1

SNX2 ACAT1 PSMD3 PSMD14

YARS PDE6D UBE2Z PDCD6

RARS PAFAH1B1

DYNLL1 RYR2

VAPA PSMC2

PSMD7

CUTA PPM1B

EPB41L1 AARS

RPS15 MLLT11

PSMA5 C1orf123 SEC22A

COMMD3 ACTR1B

CDC42SE2 PKNOX1 Module 31, n = 72, FDR Corrected pvalue 0.99401

SGCD

SLC38A3

SMPX

KCNK4

CTSA

EPDR1

FAM188A ABHD6

SPHK2

AGPAT9 IDE

PLCB4

ESYT1

ACAN DIP2B

CRTAC1 CNTNAP2 NOL3

SCN1B LUZP1

ABCB5 KCNAB1 TBC1D4

STK39 SCN4B NEFH PDCD6IP

MPP1 LGI1 KRT73 ANKRD29 HTR1B

MAPT C12orf5 EML2 ADAM23 KCNA1 KCNC3 DYSF DUSP14

KCNA2 SCN1A RIMKLA KCNC1 TESC

PTPRD KCNAB2 KCNAB2 USP8

NT5C1A CLEC2L SACS

HSD11B1 SV2C

NEXN GALNT8 ITM2A

ANXA6 ADAM22

ADAM22

PLBD2

LIMK1 SLC24A2

MYH7B

SLC12A1 LIMK2

ANK3

SLC6A8

EPB41L3

SLC6A12

EPB41L3

TRPM2 Module 32, n = 72, FDR Corrected pvalue 1

GUF1

GLRX2

HSCB

HAX1

MARS2

RNMTL1

MT-ATP8 FIS1

FAM73B

OGDH PIGS

SLC25A20

TMUB2

TRAPPC11 KIDINS220

TRMU FLII MSRB2

CCDC51 HCN4

CMC2 KCNQ5 SEZ6L2

KIAA1841 PHOSPHO1 KCNT1 ASTN2

SEC61A2 NARS2 BTBD17 PNKD MAP4K2

SSR4 NBAS ETHE1 MTFP1 STAC2 EMB B3GAT3 TATDN1

TMX2 GPCPD1 IREB2 SLC25A15 PLEKHD1

SRPK1 ABCB7 ANO8 TRAPPC8

ALDH18A1 ATP13A2 ALDOC

ACACA HOMER3

KIF21A FLAD1 DNM1L

PDZD8 TRAPPC13

PPM1L

UVRAG

ANKH CAPRIN2

CNTN6

MTRF1L ABCC1

COX6C

NGRN

UCKL1

KCNH7

FAM65A

RNF157 Module 33, n = 65, FDR Corrected pvalue 1

TTC39B MGARP

AP1S2 DLC1

KIAA1467

RBMS1 ZNF385A

GRID1 SLC2A1

NT5DC1

TPP2 HIBADH

STRBP PET100 PIPOX TIMMDC1

LGI2 PC

ZYX PEX5L

STXBP1 CADPS ACSL6 PNKD

DNAJC16 ABHD11 HAPLN4 CCDC136

NT5E SMYD2 CDS1 RELL2 PVALB SLC9A1 SLC35A4 ALDH1A1 SYT1

CPLX1 HCN2 SLC25A13 RCAN2

VARS PYGM ATP2B2 CABP1

KCNC2 PPIF

SLC25A25 EXTL2

MAGI3 PFKFB2 RRM2B ANK1

SLC25A25 OSBPL6

OSBPL6

PRUNE2 MOCS1

MAP2K7 CLASP1

YME1L1

ACSS1 AK2

HMBS CDH7 Module 34, n = 61, FDR Corrected pvalue 0.86525

SSPN MYH8

PITPNB

RIC8A NUP205

C17orf62 C5orf51 GPR37L1 CD63

LYNX1

CD55 PPP6R3

GNPNAT1 TNFAIP8L3

RAB21 OXSR1

CD151 METTL7A

CTNNA1 CD81 RAB28 PIK3CA

KPNA5 PAICS RAP1B ARL8A

COMMD4 C16orf62 GCA TNPO1 XPOT TSPAN5 SCARB2 ATG7 CMIP

SHISA4 KDSR SRI PSAP

PLSCR1 PACS2 RHOQ GNAQ

DHRS7 CYFIP1

MGST1 CD59

GNA14 TROVE2

FERMT2 RRAGB

FERMT2

CHUK C9orf64 UFSP2 CD46

ANXA7 PARVB

SEPT10

SOD1 SPG21 Module 35, n = 60, FDR Corrected pvalue 1

SNX3

YTHDC1

CHDH

UBE2L6 SRSF9

STAT1

KDM3B LIG4

FAM120B

SUPT16H UBTF

XRCC1 SND1

ACTL6A ACTL6B

BBS4

AARSD1 HNRNPH2

THOP1 LRRC47 SRSF5 UBE2G2

ATRX ABCF3 ANP32E HNRNPDL

TST SSRP1 ADI1 DTX3 UBLCP1 NSUN2 TECR GNL3

DDX5 PPM1G PPIH OARD1

VPRBP FBXO44 ADAR XRN1

ARMCX2 LIG3

CPT2

TSNAX C12orf10

PNMA2 EPM2AIP1

TSN MOCS3

NMRAL1

BYSL EIF2AK2

OGFRL1

DIS3 SKIV2L2

BCAS2

PLD3

EDC4 Module 36, n = 60, FDR Corrected pvalue 0.12774

EGFR

SPTY2D1

SPAG1

SLC8A1 APOL2

RAB11B

SLC8A1 APOL2

CPLX2

FKBP5 HAPLN3

CNNM1 ASRGL1

CKB HAPLN1

THEM6

RAB11FIP5 HAPLN1

RAB37 SNPH SRI AP1S2

C2CD2 CKM VAMP1 PRDX5

SLC8A1 GBA2 TOMM34 CD99L2 SLC6A1 SLC25A12 AIFM3 BCL2L13

CAMK2G SLC6A11 CNTFR CAMK2A

HSD17B4 GDE1 CAMK2G ARHGEF6

EFR3A STRADA

KCNIP2

FAM213A SLC12A6

CTPS1 MSL1

PGM1 PFKM

PCYOX1

HRSP12 RMDN2

PIP4K2C

SLC17A6 PLCD1

WIPF3

PTPRD

RAB31 Module 37, n = 56, FDR Corrected pvalue 0.50737

IAH1

SMS

CDK18 RRAGC

ADCYAP1R1 PPP1R11 TMEM19

TSR2

MADD CHMP4B

CSNK1A1 EPB41L1

STXBP2 CHMP5

CELF1 PSMB2

PRKCH AKT2 SEPT8 MYL3

APLP1 UBE2H TWF1 CHMP2A

SHROOM3 TKT WRB CHMP1B DNM2 CHMP2B CCDC47 TBC1D17

FZD10 PABPC1 INPP5A DESI1

ARF4 COMMD5 RTCB LAMTOR4

CHMP1A PRPSAP2

UBA5 EEF1A1

BCL2L1 ARL6IP5

GNPDA2 RUFY3

TBCA

DHX8 ARPC3 TXNL4A

LAMTOR2 SLC7A6

SDHD

PFKFB4 Module 38, n = 53, FDR Corrected pvalue 0.00025693

CARS2

TBCE CLIP1

TXLNA LMAN1

USP47

STIP1 NUDCD3

CUEDC2 TBC1D9B

NUDC CALR

SUGT1 HSPA6

FN3K HSPH1 CACYBP SPATS2

TTC1 MESDC2 FKBP4 DNAJC7

WDR12 DNAJB14 PDIA6 HSPA5 HSP90AA1 CHORDC1 ASNSD1 NAMPT SCRN3

AHSA1 HSP90AB1 HSPA8 PA2G4

PDIA3 SEC62 CNPY3 DNAJA1

EIF4A2 CDC37

ERP29 CDC37

GSKIP ARL8B

HSP90B1 PTGES3

EIF4G2

NAA50 DHCR24

CNPY2 GABARAP

MIEN1 Module 39, n = 48, FDR Corrected pvalue 0.96802

RAP1GDS1

EEF1D

ALG11

EMC7

HSP90AB2P SYNCRIP RAP1GAP

SLC39A14 FBXO22

NME2P1

FKBP2 PABPC1

SEPW1

EEF2

DRG1 EIF5B

COPB2 RPN1

SLC25A1

COPB1 EIF2S2 EIF3B RPAP3

CHN1 EIF4A1

APEH EIF5 ARCN1 COPA

FAM134B

ABCF2 EIF3L

PREPL PCNA

PPA1

ZMPSTE24

PDCL3 COPG1

TRNT1

CORO1B LNPEP

DARS SH3BGRL3 EIF3D

DPY19L1

PABPC3

BZW1

EIF3E Module 40, n = 41, FDR Corrected pvalue 0.49975

IGHG1 IGHG1

0 0

0 0 IGHG1 IGHM

IGHV3-72 0

IGKV3-11

IGHV3-74 0

IGLL5 IGLV3-10

IGKV1-17 IGKV2D-29 IGLC7 0

0 IGLC3 CD5L

IGHA1 IGHV3-30 IGLV1-51 0

IGHV3OR16-12 IGHV4-34

IGHV1-69 0

IGLV2-11

IGHG2 0

0 IGHA2 IGLV4-69 IGLV3-21

IGJ IGHG4

IGKV2D-24 IGHG3 Module 41, n = 37, FDR Corrected pvalue 0.0064004

LOC400499 EPS8L2

FRMPD3 PMFBP1

DDX24 TMOD2

S100A12 PRTN3

GNN

DEFA1 LYZ

UBA1 OTC

PIP4K2B DSCAML1 GNB3 USP24

CNKSR3 RNF144A FAXC

LCN2 RAN KMT2A S100A9

TUBA8 HES1

CTSG ACTG1 TSHZ3

HSP90AA4P LTF

S100A8 HSPA8

MPO GFAP

KDM5C CDC34 Module 42, n = 32, FDR Corrected pvalue 1

APOE SLIT1

ECE1 DAG1

SPOCK3 RENBP

NTN3

FRZB TMEFF2

MDK SPON1

HTRA1 NTN1 OLFML3 BDH2

QPRT SMOC1

SPOCK2 APP FLT1 NXPH1

CTHRC1 SLIT2

GPC5 PTN

SFRP1

COL11A1 SPOCK1

COL25A1 SDC4

LRP1 GPNMB Module 43, n = 30, FDR Corrected pvalue 0.54857

STT3A

REXO2

SEC61A1

HBS1L

FOCAD

ZYG11B

AGPAT4

ANXA6

NAA15

HIF1AN

ACO1

EIF2S1

FKBP3

USO1

MYO18A CAB39

SRP54

SEPW1

MAP1A

ZC3H15

EIF2S3

FAM98A

CCDC25 ACLY

SAR1B

ARIH1

ABCF1

RTCA

HSPA12A

DIS3L2 Module 44, n = 28, FDR Corrected pvalue 2.3129e-06

RPL7A

RPL36AL

RPS6

RPL8

RPL29

RPL27

RPL32

RPL27A

RPL15 RPL39

RPL34 RPL36

RPL13A

RPL24 RPL18A

RPS9

RPL4 RPL35

RPS18 RPL10

RPL13

RPL28

RPL6

RPL7

RPL36A

RPL37

RPL18

RPL19