Brand to Generic switches

Original Product Strength Pack Size Cost per Change to Cost per Savings per Notes Annual month month month savings/ pack

15mg 28 £25.83 £1.49 £24.34 £316.42 Actos® tablets 30mg 28 £35.89 Pioglitazone tablets £1.63 £34.26 £445.38 45mg 28 £39.55 £1.81 £37.74 £490.62

2mg 7 £3.58 £1.31 £2.02 £105.04 4mg 7 £3.88 £0.79 £3.09 £160.68 Amias® tablets 8mg 28 £9.89 Candesartan tablets £1.63 £8.26 £107.38 16mg 28 £12.72 £1.78 £10.94 £142.22 32mg 28 £16.13 £2.09 £14.04 £182.52

75mg 28 £9.69 £2.74 £6.95 £90.35 Aprovel® tablets 150mg 28 £11.84 Irbesartan tablets £4.73 £7.11 £92.43 300mg 28 £15.93 £4.25 £11.68 £151.84

10mg 30 £51.13 Leflunomide tablets 10mg £5.92 £45.21 £542.52 Arava® tablets 20mg 30 £61.36 Leflunomide tablets 20mg £6.08 £55.28 £663.36

60mg 28 £20.11 £2.97 £17.14 £222.82 Arcoxia® tablets Etoricoxib tablets 90mg 28 £22.96 £2.83 £20.13 £261.69

5mg 28 £59.85 £0.99 £58.86 £765.18 Aricept® tablets Donepezil tablets 10mg 28 £83.89 £1.15 £58.70 £763.10

5mg 28 £59.85 Donepezil orodispersible sugar free £8.87 £50.98 £662.74 Aricept Evess® tablets 10mg 28 £83.89 tablets £10.36 £73.53 £955.89

Arimidex® tablets 1mg 28 £68.56 Anastrazole tablets £1.78 £66.78 £868.14

Aromasin® tablets 25mg 30 £88.80 Exemestane tablets £7.10 £81.70 £980.40 Audmonal® capsules £14.80 £6.11 £79.43 60mg 100 Alverine citrate capsules £8.69 Spasmonal® capsules £16.45 £7.76 £100.88

Bondronat® tablets 50mg 28 £183.69 Ibandronic acid tablet £71.54 £112.15 £1,457.95

Bonviva® tablets 150mg 1 £18.40 Ibandronic acid tablet £8.96 £9.44 £113.28

50mg 28 £119.79 £4.42 £115.37 £1,499.81 Casodex® tablets Bicalutamide tablets 150mg 28 £240.00 £5.93 £234.07 £3,042.91

5mg 28 £18.03 £1.22 £16.81 £218.53 10mg 28 £18.03 £1.40 £16.63 £216.19 Crestor® tablets Rosuvastatin tablets 20mg 28 £26.02 £1.82 £24.20 £314.60 40mg 28 £29.69 £2.26 £27.43 £356.59

5mg 28 £54.99 £7.55 £47.44 £616.72 Prescriptions for generic or branded tadalafil are Cialis® tablets 10mg 4 £28.88 Tadalafil tablets £1.30 £27.58 £358.54 required to meet the SLS criteria for NHS prescribing Please see NHSE LVM data re tadalafil and 5mg 20mg 4 £28.88 £1.97 £26.91 £349.83

150mg/12.5mg 28 £11.84 £6.50 £5.34 £69.42 Please refer to MHRA alert on long-term use of CoAprovel® tablets 300mg/12.5mg 28 £15.93 Irbesartan/hydrochlorothiazide tablets £2.14 £13.79 £179.27 hydrochlorothiazide -switch away from 300mg/25mg 28 £15.93 £7.65 £8.28 £107.64 hydrochlorothiazide where possible

Colofac® tablets 135mg 100 £9.02 Mebeverine tablets £4.82 £4.20 £54.60

12.5mg 28 £9.70 £5.09 £4.61 £59.93 25mg 28 £16.18 £1.81 £14.37 £186.81 Cozaar® tablets Losartan tablets 50mg 28 £12.80 £1.90 £10.90 £141.70 100mg 28 £16.18 £2.51 £13.67 £177.71

50mg/12.5mg 28 £12.80 £1.61 £11.19 £145.47 Please refer to MHRA alert on long-term use of Cozaar-Comp® tablets 100mg/12.5mg 28 £16.18 Losartan/hydrochlorothiazide tablets £13.74 £2.44 £31.72 hydrochlorothiazide -switch away from hydrochlorothiazide where possible 100mg/25mg 28 £16.18 £1.73 £14.45 £187.85 Desmotabs® tablets 0.2mg (200mcg) 30 £29.43 Desmopressin tablets £17.75 £11.68 £151.84

Ebixa® tablets 10mg 28 £34.50 £1.62 £32.88 £427.44 or Memantine tablets Nemdatine® tablets 20mg 28 £69.01 £1.96 £67.05 £871.65 Ebixa® oral solution sugar- 10mg/5ml 50ml £61.60 Memantine oral solution sugar-free £55.14 £6.46 £83.98 Savings calculated per 50ml bottle free

75mg 28 £22.08 £2.60 £19.48 £253.24 Efexor® XL capsules Venlafaxine MR capsules 150mg 28 £36.81 £3.90 £32.91 £427.83

5mg 28 £47.56 Prasugrel tablets 5mg £24.08 £23.48 £305.24 Efient® tablets 10mg 28 £47.56 Prasugrel tablets 10mg £6.59 £40.97 £532.61

30g £4.80 £2.91 £1.89 £24.57 Elocon® cream 0.1% Mometasone cream 0.1% 100g £15.10 £9.70 £5.40 £70.20 30g £4.32 £3.11 £1.21 £15.73 Elocon® ointment 0.1% Mometasone ointment 0.1% 100g £12.44 £10.37 £2.07 £26.91

Evista® tablets 60mg 28 £17.06 Raloxifene tablets £3.90 £13.16 £171.08

Ezetrol® tablets 20mg 28 £26.31 Ezetimibe 10mg tablets £1.61 £24.70 £321.10

Femara® tablets 2.5mg 30 £90.92 Letrozole tablets £1.16 £89.76 £1,077.12

Please check if suitable to advise patient to purchase Flixonase® nasal spray 50mcg 150dose £11.01 £6.86 £4.15 £53.95 the 50mcg spray OTC. Furoate nasal spray 27.5mcg Not applicable to IESCCG

Flomaxtra® XL tablets 400mcg 30 £10.47 Tamsulosin MR capsules £3.87 £6.60 £85.80

10mg 28 £23.12 £2.63 £20.49 £266.37 Fosamax® tablets tablets 70mg 4 £22.80 £0.93 £21.20 £275.65

50mg 6 £31.85 £1.50 £30.35 £394.55 Imigran tablets tablets 100mg 6 £51.48 £1.80 £49.68 £645.84

5mg 28 £11.08 £0.83 £10.25 £133.25 Istin® tablets Amlodipine tablets 10mg 28 £16.55 £0.87 £15.68 £203.84 Lamisil® tablets 250mg 14 £21.30 Terbinafine tablets £1.78 £19.52 £507.52

Lamisil® cream 1% 30g £7.45 Terbinafine cream £3.04 £4.41 £57.33

10mg 28 £13.00 £0.87 £12.13 £157.69 20mg 28 £24.64 £1.00 £23.64 £307.32 Lipitor® tablets Atorvastatin tablets 40mg 28 £24.64 £1.24 £23.40 £304.20 80mg 28 £28.21 £1.85 £26.36 £342.68

10mg 28 £11.16 £1.03 £10.13 £131.69 Losec® capsules 20mg 28 £16.70 Omeprazole capsules £1.02 £15.68 £203.84 See also dose optimisation for 40mg capsules 40mg 7 £8.35 £0.77 £30.32 £394.16

50mg 28 £17.82 £1.27 £16.55 £215.15 Lustral® tablets Sertraline tablets 100mg 28 £29.16 £1.56 £27.60 £358.80

88mcg 30 £11.24 £4.28 £6.96 £83.52 180mcg 30 £22.49 £2.75 £19.74 £236.88 Mirapexin tablets 350mcg 30 £44.97 Pramipexole tablets £13.90 £31.07 £372.84

700mcg 30 £89.98 £2.29 £87.69 £1,052.28

0.26mg 30 £32.49 £18.85 £13.64 £163.68 0.52mg 30 £64.98 £30.74 £34.24 £410.88 1.05mg 30 £129.96 £56.68 £73.28 £879.36 A switch to generic is preferred option, however if Mirapexin® MR tablets 1.57mg 30 £202.36 Pramipexole MR tablets £118.26 £84.10 £1,009.20 branded prescribing is needed Pipexus is the most cost 2.1mg 30 £259.91 £150.58 £109.33 £1,311.96 effective 2.62mg 30 £337.27 £222.06 £115.21 £1,382.52 3.15mg 30 £389.87 £226.99 £162.88 £1,954.56

Movicol® sachets 13.125g 30 £8.11 Macrogol sachets £3.76 £4.35 £52.20

Mucodyne® capsules 375mg 120 £18.98 Carbocisteine capsules £5.12 £13.86 £180.18

Naramig tablets 2.5mg 6 £24.55 tablets £4.34 £20.21 £262.73

Please check if suitable to advise patient to purchase Nasonex® nasal spray 50mcg 140dose £7.68 Mometasone nasal spray £4.39 £3.29 £42.77 OTC, or alternative /fluticasone nasal spray OTC Plavix® tablets 75mg 30 £35.64 Clopidogrel tablets £1.49 £34.15 £409.80

30g £25.92 £17.26 £8.66 £103.92 Protopic® ointment 0.1% Tacrolimus ointment Savings calculated on one pack per month 60g £47.28 £34.52 £12.76 £153.12

Provigil tablets 100mg 30 £52.60 Modafinil tablets £3.56 £49.04 £637.52

Renagel® tablets 800mg 180 £167.04 Sevelamer tablets £81.39 £85.65 £1,113.45

8mg 56 £68.32 £61.97 £6.35 £82.55 Reminyl® tablets Galantamine tablets 12mg 56 £84.00 £74.10 £9.90 £128.70

500mcg 20 £5.08 £2.16 £2.92 £37.96 1mg 20 £8.36 £2.74 £5.62 £73.06 2mg 60 £34.62 £9.83 £24.79 £297.48 Risperdal® tablets Risperidone tablets 3mg 60 £50.91 £12.25 £38.66 £463.92 4mg 60 £67.20 £13.49 £53.71 £644.52 6mg 28 £67.88 £49.21 £18.67 £224.04

25mg 60 £48.60 £2.09 £46.51 £558.12 100mg 60 £135.72 £4.80 £130.92 £1,571.04 Seroquel® tablets Quetiapine tablets 200mg 60 £135.72 £7.09 £128.63 £1,543.56 300mg 60 £204.00 £6.18 £197.82 £2,373.84

10mg 28 £14.21 £4.47 £9.74 £126.62 Seroxat® tablets 20mg 30 £15.23 tablets £1.30 £13.93 £167.16 30mg 30 £26.74 £1.95 £24.79 £297.48

Sinemet® Plus tablets 25mg/100mg 100 12.88 Co-careldopa tablets £9.44 £3.44 £44.72 Annual cost saving calculated on one pack per month

4mg 28 £25.69 Montelukast chewable tablets sugar- £1.73 £23.96 £311.48 Singulair® Paediatric tablets 5mg 28 £25.69 free £1.81 £23.88 £310.44

Singulair® tablets 10mg 28 £26.97 Montelukast tablets £4.08 £22.89 £297.57

Singulair® Paediatric granules 4mg 28 £25.69 Montelukast granule sachets sugar free £5.35 £20.34 £264.42 120mg 30 £5.99 £2.17 £3.82 £45.84 Telfast® tablets Fexofenadine tablets 180mg 30 £7.58 £3.14 £4.44 £53.28

Tetralysal® capsules 300mg (408mg) 28 £6.95 Lymecycline capsules £4.38 £2.57 £33.41

Ramipril tablets £2.10 £2.99 £38.87 1.25mg 28 £5.09 Ramipril capsules £0.91 £4.18 £54.34 Ramipril tablets £2.06 £5.16 £67.08 2.5mg 28 £7.22 Ramipril capsules £0.93 £6.29 £81.77 Tritace® tablets Ramipril tablets £2.09 £7.96 £103.48 5mg 28 £10.05 Ramipril capsules £0.89 £9.16 £119.08 Ramipril tablets £2.12 £11.56 £150.28 10mg 28 £13.68 Ramipril capsules £0.99 £12.69 £164.97

5mg 30 £27.62 £3.54 £24.08 £288.96 Vesicare® tablets Solifenacin tablets 10mg 30 £35.91 £4.26 £31.65 £379.80

25mg 4 £16.59 £0.87 £15.72 £204.36 Viagra® tablets 50mg 4 £21.27 Sildenafil tablets £0.97 £20.30 £263.90 100mg 4 £23.50 £1.05 £22.45 £291.85

10mg 28 £5.70 £2.40 £3.30 £42.90 Zanidip® tablets Lercanidipine tablets 20mg 28 £10.82 £2.90 £7.92 £102.96

Please refer to MHRA alert on long-term use of 10mg/12.5mg 28 £13.62 £2.50 £11.12 £144.56 Zestoretic® tablets Lisinopril /Hydrochlorothiazide tablets hydrochlorothiazide -switch away from 20mg/12.5mg 28 £13.82 £2.44 £11.38 £147.94 hydrochlorothiazide where possible

5mg 28 £9.42 £0.90 £8.52 £110.76 Zestril® tablets 10mg 28 £14.76 Lisinopril tablets £0.92 £13.84 £179.92 20mg 28 £13.02 £1.00 £12.02 £156.26

Zomig® tablets 2.5mg 6 £23.94 Zolmitriptan tablets £7.66 £16.28 £211.64

2.5mg 6 £23.99 £12.38 £11.61 £150.93 Zomig Rapimelt® tablets Zolmitriptan orodispersible tablets 5mg 6 £23.94 £13.41 £10.53 £136.89 2.5mg 28 £21.85 £1.45 £20.40 £265.20 5mg 28 £43.70 £1.51 £42.19 £548.47 7.5mg 28 £131.10 £1.98 £129.12 £1,678.56 Zyprexa® tablets Olanzapine tablets 10mg 28 £87.40 £1.48 £85.92 £1,116.96 15mg 28 £119.18 £1.93 £117.25 £1,524.25 20mg 28 £158.90 £2.13 £156.77 £2,038.01

5mg 28 £48.07 £6.86 £41.21 £535.73 10mg 28 £87.40 Olanzapine orodispersible tablets £11.49 £75.91 £986.83 Zyprexa Velotab® tablets 15mg 28 £131.10 Sugar-free £11.64 £119.46 £1,552.98 20mg 28 £174.79 £18.91 £155.88 £2,026.44

This document wasproduced in collaboration by WSCCG, I&ESCCG and NEECCG January 2020