International Journal of Molecular Sciences Article Comparative Anti-Inflammatory Effects of Salix Cortex Extracts and Acetylsalicylic Acid in SARS-CoV-2 Peptide and LPS-Activated Human In Vitro Systems Nguyen Phan Khoi Le 1 , Corinna Herz 1, João Victor Dutra Gomes 1 , Nadja Förster 2, Kyriaki Antoniadou 3, Verena Karolin Mittermeier-Kleßinger 3, Inga Mewis 2 , Corinna Dawid 3 , Christian Ulrichs 2 and Evelyn Lamy 1,* 1 Molecular Preventive Medicine, University Medical Center and Faculty of Medicine, University of Freiburg, 79108 Freiburg, Germany;
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[email protected]; Tel.: +49-761-270-82150 Abstract: The usefulness of anti-inflammatory drugs as an adjunct therapy to improve outcomes in COVID-19 patients is intensely discussed. Willow bark (Salix cortex) has been used for centuries Citation: Le, N.P.K.; Herz, C.; Gomes, to relieve pain, inflammation, and fever. Its main active ingredient, salicin, is metabolized in the J.V.D.; Förster, N.; Antoniadou, K.; human body into salicylic acid, the precursor of the commonly used pain drug acetylsalicylic Mittermeier-Kleßinger, V.K.; Mewis, acid (ASA).