The Menopause What to Expect When You’Re Expecting the Menopause
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Supplemental Update Report CR Number: 2012319113 Implementation Date: 16-Jan-19 Related CR: 2012319113 MedDRA Change Requested Add a new SMQ Final Disposition Final Placement Code # Proposed SMQ Infusion related reactions Rejected After Suspension MSSO The proposal to add a new SMQ Infusion related reactions is not approved after suspension. The ICH Advisory Panel did approve this SMQ topic to go into the development phase and it Comment: underwent testing in three databases (two regulatory authorities and one company). However, there were numerous challenges encountered in testing and the consensus decision of the CIOMS SMQ Implementation Working Group was that the topic could not be developed to go into production as an SMQ. Most notably, in contrast to other SMQs, this query could not be tested using negative control compounds because it was not possible to identify suitable compounds administered via infusion that were not associated with some type of reaction. In addition, there is no internationally agreed definition of an infusion related reaction and the range of potential reactions associated with the large variety of compounds given by infusion is very broad and heterogenous. Testing was conducted on a set of around 500 terms, the majority of which was already included in Anaphylactic reaction (SMQ), Angioedema (SMQ), and Hypersensitivity (SMQ). It proved difficult to identify potential cases of infusion related reactions in post-marketing databases where the temporal relationship of the event to the infusion is typically not available. In clinical trial databases where this information is more easily available, users are encouraged to provide more specificity about the event, e.g., by reporting “Anaphylactic reaction” when it is known that this event is temporally associated with the infusion. -
Livedoid Vasculopathy Associated with Peripheral Neuropathy: a Report of Two Cases* Vasculopatia Livedoide Associada a Neuropatia Periférica: Relato De Dois Casos
CASE REPORT 227 s Livedoid vasculopathy associated with peripheral neuropathy: a report of two cases* Vasculopatia livedoide associada a neuropatia periférica: relato de dois casos Mariana Quirino Tubone1 Gabriela Fortes Escobar1 Juliano Peruzzo1 Pedro Schestatsky2 Gabriela Maldonado3 DOI: http://dx.doi.org/10.1590/abd1806-4841.20132363 Abstract: Livedoid vasculopathy (LV) is a chronic and recurrent disease consisting of livedo reticularis and sym- metric ulcerations, primarily located on the lower extremities, which heal slowly and leave an atrophic white scar ("atrophie blanche"). Neurological involvment is rare and presumed to be secondary to the ischemia from vascu- lar thrombosis of the vasa nervorum. Laboratory evaluation is needed to exclude secondary causes such as hyper- coagulable states, autoimmune disorders and neoplasms. We present two patients with a rare association of peripheral neuropathy and LV, thereby highlighting the importance of a multidisciplinary approach to reach the correct diagnosis. Keywords: Livedo reticularis; Mononeuropathies; Polyneuropathies; Skin diseases, vascular Resumo: Vasculopatia livedoide é uma doença crônica e recorrente caracterizada por livedo reticular e úlceras simétricas nos membros inferiores, que cicatrizam e deixam uma cicatriz branca atrófica ("atrophie blanche"). Envolvimento neurológico é raro e está provavelmente associado a isquemia pela trombose dos vasa nervorum. Avaliação laboratorial é indicada com o intuito de excluir causas secundárias como estados de hipercoagulabili- dade, doenças autoimunes e neoplasias. Apresentamos dois pacientes com uma rara associação de vasculopatia livedoide com neuropatia periférica, enfatizando a importância de uma abordagem multidisciplinar na busca do diagnóstico correto. Palavras-chave: Dermatopatias vasculares; Livedo reticular; Mononeuropatias; Polineuropatias INTRODUCTION Livedoid vasculopathy (LV) is a chronic and resentation of the dermo-hypodermic junction, was recurrent disease, usually restricted to the skin, and compatible with LV. -
COVID-19 Mrna Pfizer- Biontech Vaccine Analysis Print
COVID-19 mRNA Pfizer- BioNTech Vaccine Analysis Print All UK spontaneous reports received between 9/12/20 and 22/09/21 for mRNA Pfizer/BioNTech vaccine. A report of a suspected ADR to the Yellow Card scheme does not necessarily mean that it was caused by the vaccine, only that the reporter has a suspicion it may have. Underlying or previously undiagnosed illness unrelated to vaccination can also be factors in such reports. The relative number and nature of reports should therefore not be used to compare the safety of the different vaccines. All reports are kept under continual review in order to identify possible new risks. Report Run Date: 24-Sep-2021, Page 1 Case Series Drug Analysis Print Name: COVID-19 mRNA Pfizer- BioNTech vaccine analysis print Report Run Date: 24-Sep-2021 Data Lock Date: 22-Sep-2021 18:30:09 MedDRA Version: MedDRA 24.0 Reaction Name Total Fatal Blood disorders Anaemia deficiencies Anaemia folate deficiency 1 0 Anaemia vitamin B12 deficiency 2 0 Deficiency anaemia 1 0 Iron deficiency anaemia 6 0 Anaemias NEC Anaemia 97 0 Anaemia macrocytic 1 0 Anaemia megaloblastic 1 0 Autoimmune anaemia 2 0 Blood loss anaemia 1 0 Microcytic anaemia 1 0 Anaemias haemolytic NEC Coombs negative haemolytic anaemia 1 0 Haemolytic anaemia 6 0 Anaemias haemolytic immune Autoimmune haemolytic anaemia 9 0 Anaemias haemolytic mechanical factor Microangiopathic haemolytic anaemia 1 0 Bleeding tendencies Haemorrhagic diathesis 1 0 Increased tendency to bruise 35 0 Spontaneous haematoma 2 0 Coagulation factor deficiencies Acquired haemophilia -
Cerebral Venous Thrombosis and Livedo Reticularis in a Case with MTHFR 677TT Homozygote
Journal of Clinical Neurology / Volume 2 / June, 2006 Case Report Cerebral Venous Thrombosis and Livedo Reticularis in a Case with MTHFR 677TT Homozygote Jee-Young Lee, M.D., Manho Kim, M.D., Ph.D. Department of Neurology, College of Medicine, Seoul National University, Seoul, Korea Hyperhomocysteinemia associated with methylene terahydrofolate reductase (MTHFR) mutation can be a risk factor for idiopathic cerebral venous thrombosis. We describe the first case of MTHFR 677TT homozygote with cerebral venous thrombosis and livedo reticularis. A 45-year-old man presented with seizures and mottled-like skin lesions, that were aggravated by cold temperature. Hemorrhagic infarct in the right frontoparietal area with superior sagittal sinus thrombosis was observed. He had hyperhomocysteinemia, low plasma folate level, and MTHFR 677TT homozygote genotype, which might be associated with livedo reticularis and increase the risk for cerebral venous thrombosis. J Clin Neurol 2(2):137-140, 2006 Key Words : Livedo reticularis, Methylene tetrahydrofolate reductase, Cerebral venous thrombosis Hyperhomocysteinemia causes vascular endothelial venous infarct due to cerebral venous thrombosis. damage that result in atherosclerosis and ischemic strokes.1 It is also associated with prothrombotic state or venous thromboembolism2 including cerebral venous CASE REPORT thrombosis.3 Among the thrombophilic factors with hyperhomocysteinemia, methylene tetrahydrofolate reduc- A 45 year-old man was brought to the emergency tase (MTHFR) mutant (C677 → T, homozygote) with room with uncontrolled seizures. Two days ago, sudden low plasma folate concentration increases the risk for paresthesia in left arm developed, which progressed to cerebral venous thrombosis.4 MTHFR 677TT is thermo- tonic posturing and leftward head version, followed by labile and sensitive to temperature alteration.5 a generalized tonic clonic seizure. -
Faculty Meeting August 9Th, 2011
Review of Systems is a process that includes a review of body systems. It is carried out through a series of questions regarding signs and symptoms. The Review of Systems (ROS) includes information about the following 14 systems. Constitutional: description of general appearance; growth and development, recent weight loss/gain, malaise, chills weakness, fatigue, fever, vital signs, head circumference for a baby, appetite, sleep habits, insomnia, night sweats. Integumentary: (skin and/or breast) rashes, color, sores, dryness, itching, flaking, dandruff, lumps, moles, color change, changes in hair or nails, sweating, hives, bruising, scratches, scars, swelling., acne. Eyes: vision, no change in vision, glasses or contact lenses, last eye exam, eye pain, “eye” redness, excessive tearing, double vision, blurred vision, spots, specks, flashing lights, photophobia, glaucoma, cataracts. Ears, Nose, Mouth/ Throat Ears: hearing loss, tinnitus, vertigo, earaches, ear infections, ear discharges; if hearing is decreased, use of hearing aids. Nose and sinuses: frequent colds, stuffiness’, discharge drainage, nasal itching, hay fever, nosebleeds sinusitis, sinus trouble, sinus pressure, nasal congestion, nasal discharge, nasal infection Mouth/Throat condition of teeth and gums bleeding gums dentures, (how they fit) last dental exam, dry mouth, frequent sore throats, difficulty swallowing, no posterior pharynx pain, hoarseness, sores/ulcers, hoarseness, pyorrhea. Respiratory: cough, sputum, (color, quantity) shortness of breath, pleuritic chest pain, wheezing, asthma, bronchitis, TB, emphysema, pneumonia, hemoptysis, CXR. Cardiovascular: heart trouble; high blood pressure; CV hypertension, heart murmurs, chest pain/ pressure palpitations, dyspnea, orthopnea,, rheumatic fever, paroxysmal nocturnal dyspnea, edema; past EKG or other heart tests. Peripheral Vascular; intermittent claudication, leg cramps, varicose veins, past clots in the vein, syncope, edema. -
Ekbom Syndrome: a Delusional Condition of “Bugs in the Skin”
Curr Psychiatry Rep DOI 10.1007/s11920-011-0188-0 Ekbom Syndrome: A Delusional Condition of “Bugs in the Skin” Nancy C. Hinkle # Springer Science+Business Media, LLC (outside the USA) 2011 Abstract Entomologists estimate that more than 100,000 included dermatophobia, delusions of infestation, and Americans suffer from “invisible bug” infestations, a parasitophobic neurodermatitis [2••]. Despite initial publi- condition known clinically as Ekbom syndrome (ES), cations referring to the condition as acarophobia (fear of although the psychiatric literature dubs the condition “rare.” mites), ES is not a phobia, as the individual is not afraid of This illustrates the reluctance of ES patients to seek mental insects but rather convinced that they are infesting his or health care, as they are convinced that their problem is her body [3, 4]. This paper deals with primary ES, not the bugs. In addition to suffering from the delusion that bugs form secondary to underlying psychological or physiologic are attacking their bodies, ES patients also experience conditions such as drug reaction or polypharmacy [5–8]. visual and tactile hallucinations that they see and feel the While Morgellons (“the fiber disease”) is likely a compo- bugs. ES patients exhibit a consistent complex of attributes nent on the same delusional spectrum, because it does not and behaviors that can adversely affect their lives. have entomologic connotations, it is not included in this discussion of ES [9, 10]. Keywords Parasitization . Parasitosis . Dermatozoenwahn . Valuable reviews of ES include those by Ekbom [1](1938), Invisible bugs . Ekbom syndrome . Bird mites . Infestation . Lyell [11] (1983), Trabert [12] (1995), and Bak et al. -
What Are Panic Attacks?
What are Panic Attacks? Understanding the body’s “Fight or Flight” response to a threat. We all have a built-in alarm system that turns on automatically to make sure we survive whatever danger triggers it. This alarm is a lot like a burglar alarm on a house; once it detects something that might be a threat, it automatically sets off several events. If someone were breaking into your house, you would want the alarm system to call the police immediately. You would also likely want to turn on lights and even sound an audible alarm to wake you and scare off the intruder. The brain’s alarm system sets off a series of events as well, commonly called the “fight or flight” response. The fight or flight response is meant to put us in a state of high alert so that we can fight off an enemy or flee to escape with our lives. This alarm makes us faster and stronger and more focused than we would normally be. Our ancestors may not have survived if the human body was not hardwired with the fight or flight response. The reaction is automatic. It helps us survive, and we do not have to think about it; it just happens. But because it is automatic, we do not get to choose which things will set it off. Sometimes, the fight or flight response can start firing if it thinks there is danger, even when there isn’t any real threat around. This is especially common in people who have been through a traumatic event. -
Livedoid Vasculopathy – Benefit of Intravenous Immunoglobulin in A
CASE REPORTS Ref: Ro J Rheumatol. 2021;30(1) DOI: 10.37897/RJR.2021.1.4 LIVEDOID VASCULOPATHY – BENEFIT OF INTRAVENOUS IMMUNOGLOBULIN IN A REFRACTORY CASE Stefan Cristian Dinescu1, Andreea Lili Barbulescu2, Paulina Lucia Ciurea1, Roxana Mihaela Dumitrascu3, Beatrice Andreea Chisalau3, Cristina Dorina Parvanescu3, Sineta Cristina Firulescu4, Florentin Ananu Vreju1 1 Department of Rheumatology, University of Medicine and Pharmacy, Craiova, Romania 2 Department of Pharmacology, University of Medicine and Pharmacy, Craiova, Romania 3Doctoral School, University of Medicine and Pharmacy, Craiova, Romania 4 Department of Rheumatology, Emergency County Hospital, Craiova, Romania Abstract Livedoid vasculopathy is a rare vascular disease which typically manifests as recurrent ulcerative lesions on the lower extremities. It is classified as a vasculopathy, not a true vasculitis, and defined as a vasooclusive syndrome, caused by non-inflammatory thrombosis of the upper and mid-dermal venulae. Main disorders associated with LV include thrombophilias, autoimmune diseases and neoplasia. A triad of clinical features is present in most patients and consist of livedo racemosa (less frequently livedo reticularis), ulcerations and atrophie blanche. Management generally relies on antiplatelet drugs, anticoagulants, vasodilators and fibrinolytic therapy. Some benefit has been observed with intravenous immunoglobulin, colchicine, hyperbaric oxygen, while glucocorticoids are efficient to a lesser extent. This case report highlights a refractory clinical form with no identifiable predisposing condition, which proved responsive only to intravenous immunoglobulin. Keywords: thrombosis, purpura, ulcer, intravenous immunoglobulins INTRODUCTION cal form with no identifiable predisposing condition, which proved responsive only to intravenous immu Livedoid vasculopathy (LV) is a rare vascular dis noglobulin. ease which typically manifests as recurrent ulcerative lesions on the lower extremities. -
Chronic Pain:Useful Terms Personal Injury
Chronic pain:useful terms Personal Injury Analgesic - (also known as a painkiller) is any member of the group of drugs used to relieve pain. Epidural - Epidurals are given for the relief of pain. A cocktail of drugs containing a corticosteriod and a local anaesthetic is injected into the epidural space, between the bone and the membrane that encloses the spinal cord. Fusion - Surgical procedure designed to abolish movement across a joint. Usually involves bone grafting and sometimes metal fixation. Gout - Gout is a type of arthritis that causes sudden and extremely painful inflammatory attacks in the joints – most commonly the big toe, ankles and knees but any other joint too. Guanethidine Blocks – Tourniquet is applied to the limb and guanethidine is injected into a vein to temporarily treat Complex Regional Pain Syndrome symptoms. Hydrotherapy - formerly called hydropathy involves the use of water for pain-relief and treating illness. Hyperalgesia - The perception of a painful stimulus as more painful than normal. Instability - A term used to describe an abnormal increase in the movement of one vertebrae to another. Local Anaesthetic Blocks – Local anaesthetic is injected around the sympathetic nerves from a temporary sympathetic block to treat Complex Regional Pain Syndrome. MRI Scan - Magnetic Resonance Imaging involves a highly technical scanner that uses magnetic fields and computer technology to generate images of the internal anatomy of the body, including discs and nerve roots. It is a painless procedure, although like CT scans, people with claustrophobia may find it difficult. Myelography - A water-soluble, radio-opaque dye is injected into the cerebro-spinal fluid. -
Sneddon's Syndrome
DOI: 10.5272/jimab.14-1-2010.72 Journal of IMAB - Annual Proceeding (Scientific Papers) 2008, vol. 14, book 1 SNEDDON’S SYNDROME Valentin Valtchev1, Virginia Simeonova2 , Dimitar Gospodinov1, Ivelina Yordanova1, Valentina Dimitrova1, Verka Pavlova1, Emiliana Konova4, S. Popovska3 , Boyko Stamenov2 1Department of Dermatology and Venereology, 2Department of Neurology, 3Department of General and Clinical Pathology, 4Department of Immunology, Medical University – Pleven, Bulgaria ABSTRACT pressure and migraine for 10 years. She has been having Sneddon’s syndrome is usually characterized by the persistent cutaneous lesions on the upper and lower association of an ischemic cerebrovascular disease and a extremities and trunk for the last 20 years. widespread livedo reticularis. The incidence of Sneddon At physical examination, a slight elevation in syndrome is 4/1000 000. We present 42-year-old woman with pressure levels (150 x 80mm Hg), III degree obesity and livedo reticularis, recurrence ischaemic cerebrovascular slight edema of the lower limbs were found. The accidents, two repetitive miscarriages and positive anti-2GPi neurological examination revealed ataxic walk. Romberg antibodies. Skin biopsy specimens reveal inflammatory reflex was negative (-) and Babinski was positive (+) in changes of small- to medium-sized arteries and right. The ophthalmologic examination demonstrated an subendothelial proliferation and fibrosis. The diagnosis initial angiosclerosis. The dermatological examination Sneddon syndrome is confirmed by skin biopsy, and MR showed erythematous violaceous lesions with a reticular evidence. pattern, localized in the arms, trunk (Figure 1) thighs and We suggest that anti-2GPi antibodies may be knees (Figure 2, Figure 3). The following exams in the pathophysiologically related to the clinical manifestation laboratorial evaluation were normal or negative: blood count observed in some patients with Sneddon syndrome. -
Upper Limb Pain and Paresthesia in a Post-Stroke Patient Treated With
02 Brain Neurorehabil. 2018 Mar;11(1):e1 https://doi.org/10.12786/bn.2018.11.e1 pISSN 1976-8753·eISSN 2383-9910 Brain & NeuroRehabilitation Case Upper Limb Pain and Paresthesia in a Post-Stroke Patient Treated with Ultrasound-Guided Electrical Twitch-Obtaining Intramuscular Stimulation(ETOIMS) of Scalene Muscles Je Shik Nam, Yeo-Reum Choe, Seo Yeon Yoon, Tae Im Yi Received: Sep 1, 2017 Highlights Revised: Sep 29, 2017 Accepted: Oct 2, 2017 • Disputed thoracic outlet syndrome (TOS) can be one of the possible causes of post-stroke Correspondence to pain. Tae Im Yi • Ultrasound-guided electrical twitch-obtaining intramuscular stimulation can be used as a Departments of Rehabilitation Medicine, safe and minimally invasive technique for the treatment of the disputed TOS. Bundang Jesaeng General Hospital, • Large-scale randomized controlled studies are needed to confirm its therapeutic efficacy. 20 Seohyeon-ro 180 beon-gil, Bundang-gu, Seongnam 13590, Korea. E-mail: [email protected] Copyright © 2018. Korea Society for Neurorehabilitation i 02 Brain Neurorehabil. 2018 Mar;11(1):e1 https://doi.org/10.12786/bn.2018.11.e1 pISSN 1976-8753·eISSN 2383-9910 Brain & NeuroRehabilitation Case Upper Limb Pain and Paresthesia in a Post-Stroke Patient Treated with Ultrasound-Guided Electrical Twitch-Obtaining Intramuscular Stimulation(ETOIMS) of Scalene Muscles Je Shik Nam , Yeo-Reum Choe , Seo Yeon Yoon , Tae Im Yi Department of Rehabilitation Medicine, Bundang Jesaeng General Hospital, Seongnam, Korea Received: Sep 1, 2017 ABSTRACT Revised: Sep 29, 2017 Accepted: Oct 2, 2017 In post-stroke patients, the pain or paresthesia of the affected limb is common. -
Prognosis of a Case with Paresthesia Associated with Prolonged Touching of an Endodontic Paste to the Inferior Alveolar Nerve
J Clin Exp Dent. 2011;3(Suppl1):e377-81. Inferior alveolar nerve paresthesia. Journal section: Oral Surgery doi:10.4317/jced.3.e377 Publication Types: Case Report Prognosis of a case with paresthesia associated with prolonged touching of an endodontic paste to the inferior alveolar nerve M. Cemil Buyukkurt 1, Hakan Arslan 2, H. Sinan Topcuoglu 2, M. Melih Omezli 3 1 PhD, DDS. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sifa University, İzmir, Turkey 2 DDS. Department of Endodontic, Faculty of Dentistry, Ataturk University, Erzurum, Turkey 3 DDS. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ataturk University, Erzurum, Turkey Correspondence: Department of Endodontic, Faculty of Dentistry, Ataturk University, Erzurum, 25240, Turkey E-mail address: [email protected] Received: 10/02/2011 Accepted: 08/05/2011 Buyukkurt MC, Arslan H, Topcuoglu HS, Omezli MM. Prognosis of a case with paresthesia associated with prolonged touching of an endodontic paste to the inferior alveolar nerve. J Clin Exp Dent. 2011;3(Suppl1):e377- 81. http://www.medicinaoral.com/odo/volumenes/v3iSuppl1/jcedv3iSu- ppl1p377.pdf Article Number: 50506 http://www.medicinaoral.com/odo/indice.htm © Medicina Oral S. L. C.I.F. B 96689336 - eISSN: 1989-5488 eMail: [email protected] Abstract Paresthesia is described as an abnormal sensation, such as burning, pricking, tickling, tingling, formication or num- bness. Several conditions can cause paresthesia. This article presents a case of paresthesia caused by the extrusion of endodontic paste (Endomethasone®) into the mandibular canal. The clinical manifestations comprised the numb- ness on the right side of the mandible and right lower lip, appearing after endodontic treatment.