Robert Dachs, MD, FAAFP 8:30 – 9:00 Am Common ENT Problems
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Jack Uecker, MD Auditor
r. PAUL-RAMSEY HOSPITAL and MEDICAL CENTER ST. PAUL, MINNtSOTA 55101 Anat om i c Patho logy Sem inar Spring Breast- Fest St. Paul-Ramsey Hosp i tal and Med ica l Cen te r Moderator: Jack Uecke r, M.D . Aud i tor i um - 6 :00p.m. - June 4, 1975 Buffet .,; 11 be served CASE /1 1 Thi s 87 year old female presented with a nontender breast nodul e present for about one year. On exam ination the left breast contained a fi rm thick 1 em. tumor. A simpl e mastectomy 1·1as performed and the gross examination of the tumo r shoHed a hard nodu l e of c risp white fi brous tissue flecked with smal l yel l O\~ areas. Subm I tted by: Centra l Reg iona l Pa thology Laborat ~ry St. Paul, Minnesota CAS E #2 Thi s 42 year o ld fema l e presen ted with a fi rm mass of t he ri ght breast. The clinical di agnosis was "fibroma ". At surgery a 10 em. in greatest diameter mass of s oft rubbo fibrous appearing tissue was submitted. Subm itted by: Department of Pathology University of North pako ta Grand Forks, Nor th Da kota CASE /13 Thi s 18 year ol d unmarried 1·1oman presented wi t h a four ~1eek hi story of an enl<!rging breast mass located deep to the nipple and s li ghtly toward the outer quadrant. She also noted some "e nlarged nodes" underneath her a rm but she was otherwise asymptomat A blop$y ~1as performed and a soft poorly defined 2.5 em . -
The Pathology of Breast Cancer - Ali Fouad El Hindawi
MEDICAL SCIENCES – Vol.I -The Pathology of Breast Cancer - Ali Fouad El Hindawi THE PATHOLOGY OF BREAST CANCER Ali Fouad El Hindawi Cairo University. Kasr El Ainy Hospital. Egypt. Keywords: breast cancer, breast lumps, mammary carcinoma, immunohistochemistry Contents 1. Introduction 2. Types of breast lumps 3. Breast carcinoma 3.1 In Situ Carcinoma of the Mammary Gland 3.1.1 Lobular Neoplasia (LN) 3.1.2 Duct Carcinoma in Situ (DCIS) 3.2 Invasive Carcinoma of the Mammary Gland 3.2.1 Microinvasive Carcinoma of the Mammary Gland 3.2.2 Invasive Lobular Carcinoma (ILC) 3.2.3 Invasive Duct Carcinoma 3.3 Paget’s disease of the Nipple 3.4 Bilateral Breast Carcinoma 4. Conclusions Glossary Bibliography Summary Breast cancer is the most common cancer in females. It may have strong family history (genetically related). It most commonly arises from breast ducts and less frequently from lobules. Since mammary carcinoma is the most common form of breast malignancy and one of the most common human cancers, most of this chapter is concentrated on the differential diagnosis of breast carcinoma 1. Introduction In clinicalUNESCO practice, a breast lump is very common.– EOLSS It may be accompanied in some cases by other patient’s complaints such as pain and/ or nipple discharge, which may be bloody. Sometimes more than one lump is detected in the same breast, or in both breasts. Cutaneous manifestations asSAMPLE nipple retraction, nipple and/ orCHAPTERS skin erosion, skin dimpling, erythema and peau d’ orange may also be noted; both by the patient and her physician. A lump may not be palpable in spite of breast symptoms such as pain and or nipple discharge. -
Breast Cancer
10 Breast Cancer WENDY Y. CHEN • SUSANA M. CAMPOS • DANIEL F. HAYES Table 10. 1 B reast cancer is a major cause of morbidity and mortality across the world. In the United States, each year about 180,000 Estimated Lifetime Incidence of Cancer for BRCA1/2 new cases are diagnosed with more than 40,000 deaths annu- Mutation Carriers ally ( Jemal et al., 2007). It is a highly heterogeneous disease, Type of Cancer BRCA1 Carrier BRCA2 Carrier both pathologically and clinically. Although age is the single Breast 40–85 40–85 most common risk factor for the development of breast can- Ovarian 25–65 15–25 cer in women (see Fig. 10.13 ), several other important risk Male breast 5–10 5–10 factors have also been identified, including a germline muta- Prostate Elevated * Elevated * tion ( BRCA1 and BRCA2 ) ( Table 10.1 ), positive family his- Pancreatic <10 <10 tory, prior history of breast cancer, and history of prolonged, uninterrupted menses (early menarche and late first full-term * Prostate cancer risk is probably elevated, but absolute risk is not known. Adapted from Table 19.1 in Harris et al., 2004 . pregnancy) ( Table 10.2 ). Much progress has been made in the diagnosis and treatment of primary and metastatic breast cancer. The widespread use of 10.44 ). Magnetic resonance imaging (MRI) of the breast may be routine mammography has led to an increased incidence in the useful in screening women with a higher lifetime risk of breast detection of early primary lesions, a factor that has contributed cancer, such as those women with a BRCA1/2 mutation or with a to a significant decrease in mortality (see Figs. -
Enlarging Nodule on the Nipple
PHOTO CHALLENGE Enlarging Nodule on the Nipple Caren Waintraub, MD; Brianne Daniels, DO; Shari R. Lipner, MD, PhD Eligible for 1 MOC SA Credit From the ABD This Photo Challenge in our print edition is eligible for 1 self-assessment credit for Maintenance of Certification from the American Board of Dermatology (ABD). After completing this activity, diplomates can visit the ABD website (http://www.abderm.org) to self-report the credits under the activity title “Cutis Photo Challenge.” You may report the credit after each activity is completed or after accumulating multiple credits. A healthy 48-year-old woman presented with a growth on the right nipple that had been slowly enlarging over the last few months. She initially noticed mild swellingcopy in the area that persisted and formed a soft lump. She described mild pain with intermittent drainage but no bleeding. Her medical history was unremarkable, including a negativenot personal and family history of breast and skin cancer. She was taking no medications prior to development of the mass. She had no recent history of pregnancy or breastfeeding. A mammo- Dogram and breast ultrasound were not concerning for carcinoma. Physical examination showed a soft, exophytic, mildly tender, pink nodule on the right nipple that measured 12×7 mm; no drainage, bleeding, or ulceration was present. The surround- ing skin of the areola and breast demonstrated no clinical changes. The contralateral breast, areola, and nipple were unaffected. The patient had no appreciable axillary or cervical lymphadenopathy. A deep shave biopsy of the noduleCUTIS was performed and sent for histopathologic examination. -
1 IPC II Œ Quick Review Œ Abdominal Examination
IPC II – Quick Review – Abdominal Examination Abdominal Examination Goals and Objectives: 1. Review normal abdominal examination a. Inspection, auscultation, percussion and palpations techniques I. Inspection Surface characteristics: Skin, Venous return, Lesions/scars, Tautness/ Striae, Contour, Location of umbilicus, Symmetry, Surface motion - Motion with respiration, Peristaltic waves, Pulsations Causes of distention: (The 9 F’s) Fat, Fluid, Feces, Fetus, Flatus, Fibroid, Full bladder, False pregnancy, Fatal tumor Types of distention: –Generalized –Below umbilicus –Above umbilicus –Asymmetric II. Palpation a. Used to assess the organs, detect muscle spasm, fluid, and tenderness b. Begin with Light Palpation of all 4 quadrants to detect muscular resistance (indicating peritoneal irritation) and areas of tenderness. Palpate the area that the patient complains of pain in-last. c. Progress to Moderate Palpation over all 4 quadrants to elicit tenderness that was not present with Light Palpation d. Use Deep Palpation to thoroughly delineate abdominal organs and to detect less obvious masses e. If a mass can no longer be detected when the patient lifts his/her head from the table (i.e., contracting the abdominal muscles), it is in the abdominal cavity, and not the abdominal wall f. Palpate the umbilical ring, and around the umbilicus for potential hernias III. Percussion a. Used to detect the size and density of the abdominal organs, fluid (ascites), air (gastric distention), or fluid-filled/solid masses b. Percuss all 4 quadrants for a sense of tympany or dullness 1. Tympany is heard over regions of air, i.e., stomach and intestines 2. Dullness is heard over organs and solid masses c. -
Nipple Adenoma in a Female Patient Presenting with Persistent Erythema
Spohn et al. BMC Dermatology (2016) 16:4 DOI 10.1186/s12895-016-0041-6 CASEREPORT Open Access Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin Gina P. Spohn1*, Shannon C. Trotter1, Gary Tozbikian2 and Stephen P. Povoski3* Abstract Background: Nipple adenoma is a very uncommon, benign proliferative process of lactiferous ducts of the nipple. Clinically, it often presents as a palpable nipple nodule, a visible nipple skin erosive lesion, and/or with discharge from the surface of the nipple skin, and is primarily seen in middle-aged women. Resultantly, nipple adenoma can clinically mimic the presentation of mammary Paget’s disease of the nipple. The purpose of our current case report is to present a comprehensive review of the available data on nipple adenoma, as well as provide useful information to health care providers (including dermatologists, breast health specialists, and other health care providers) who evaluate patients with dermatologic conditions of the breast skin for appropriately clinically recognizing, diagnosing, and treating patients with nipple adenoma. Case presentation: Fifty-three year old Caucasian female presented with a one year history of erythema and induration of the skin of the inferior aspect of the right nipple/areolar region. Skin punch biopsies showed subareolar duct papillomatosis. The patient elected to undergo complete surgical excision with right central breast resection. Final histopathologic evaluation confirmed nipple adenoma. The patient is doing well 31 months after her definitive surgical therapy. -
Frcpath Part 2 Histopathology Examination Histology Short Cases Commentary
FRCPath Part 2 Histopathology Examination Histology short cases Commentary. Case 1. History. Female age 64. Tumour right kidney on scan. Partial nephrectomy. Tumour 18mm diameter. Diagnosis: Angiomyolipoma of kidney. Average mark 3.12/5 This case was included as a good example of a relatively uncommon lesion, but nevertheless a lesion that candidates sitting the FRCPath Part 2 exam should be expected to diagnose with confidence. Pass marks were awarded to candidates who gave a diagnosis or renal angiomyolipoma and gave a competent basic description. Diagnoses of epithelioid angiomyolipoma were also accepted. Additional marks were awarded to candidates who gave a more complete answer and added value to their answers as follows. Extensive sampling should be undertaken in order to exclude other soft tissue and sarcomatoid tumours. Immunohistochemical staining might include smooth muscle markers and melanocytic markers (actin, desmin, HMB45, melan A). Additional commentary could have included useful clinical information such as confirming that this is a benign tumour cured by local excision (although vessel space invasion and regional lymph node invasion may occasionally be seen). Angiomyolipoma is part of the PECOMA group of tumours and has associations with the tuberose sclerosis complex. Angiomyolipomas are usually solitary but multiple tumours are seen in up to 20% of individuals and multiple lesions are more common in tuberose sclerosis. Candidates who made a diagnosis of benign vascular hamartoma or benign mesenchymal tumour were awarded a borderline fail. Any malignant diagnoses were awarded a clear fail mark. The majority of the candidates answered this question well, and most added some value with useful commentaries. -
Uncommon Differential Diagnosis of Acute Right-Sided Abdominal Pain – Case Report
CASE REPORT SURGERY // RADIOLOGY Uncommon Differential Diagnosis of Acute Right-sided Abdominal Pain – Case Report Cédric Kwizera1, Benedikt Wagner2, Johannes B. Wagner3, Călin Molnar1 1 Department of Surgery, Emergency County Hospital, Târgu Mureș, Romania 2 Student, Faculty of General Medicine, University of Medicine, Pharmacy, Science and Technology, Târgu Mureș, Romania 3 Department of General, Abdominal and Endovascular Surgery, District Hospital Landsberg am Lech, Germany CORRESPONDENCE ABSTRACT Cédric Kwizera The appendix is a worm-like, blind-ending tube, with its base on the caecum and its tip in Str. Gheorghe Marinescu nr. 50 multiple locations. Against all odds, it plays a key role in the digestive immune system and 540136 Târgu Mureș, Romania appendectomy should therefore be cautiously considered and indicated. We report the case Tel: +40 729 937 393 of a 45-year-old male with a known history of Fragile-X syndrome who presented to the emer- E-mail: [email protected] gency department with intense abdominal pain and was suspected of acute appendicitis, after a positive Dieulafoy’s triad was confirmed. The laparoscopic exploration showed no signs of ARTICLE HISTORY inflammation of the appendix; nonetheless, its removal was carried out. Rising inflammatory laboratory parameters led to a focused identification of a pleural empyema due to a tooth inlay Received: February 22, 2019 aspiration. Our objective is to emphasize the importance of a thorough anamnesis, even in Accepted: March 27, 2019 cases of mentally impaired patients, as well as to highlight a rare differential diagnosis for ap- pendicitis. Acute appendicitis is an emergency condition that requires a thorough assessment and appropriate therapy. -
SG Jordan MD and SB O'connor MD Departments of Radiology And
World Health Organization 5thed Classification of Tumours of the Breast SG Jordan MD and SB O’Connor MD Departments of Radiology and Pathology and Laboratory Medicine Introduction Invasive Breast Carcinoma (IBC) Fibroepithelial tumours and hamartomas Genetic tumour syndromes The World Health Organization (WHO) establishes the standard Breast Cancer 2019 Fibroadenoma NEW! in this WHO edition for histopathologic diagnoses, defining diagnoses on a per organ Phyllodes tumour: Benign, Borderline, Malignant system basis. Estimated new cases and deaths from breast cancer in the US Hamartoma is a section delineating the familial predisposition to breast cancer, specifically the established and The most recent classification of breast tumors is the 5th edition New cases: 268,600 15.2 % of all new cancer cases emergent genes that are a source of discussion. published in November 2019. The publication reflects the views Deaths: 41,760 6.9 % of all cancer deaths BRCA1 and BRCA2 are well-established, and of the WHO Classification of Tumours Editorial Board that increasingly PALB2, as important predisposition convened at MD Anderson Cancer Center, Houston, USA Invasive Breast Carcinoma (IBC) refers to a large and heterogeneous group of malignant genes that merit testing in all patients with suspicion December 9-11, 2018. 153 authors from 21 countries epithelial neoplasms of breast glandular elements. IBCs are classified by morphology of familial predisposition. Many other genes (two contributed. The end result is an authoritative reference book (below). All IBCs are grouped into biomarker-defined subtypes for treatment, based on examples are ATM, CHEK2) have been identified in that serves as the international standard for oncologists and estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2). -
WHO Classification of Tumors of the Central Nervous System
Appendix A: WHO Classification of Tumors of the Central Nervous System WHO Classification 1979 • Ganglioneuroblastoma • Anaplastic [malignant] gangliocytoma and Zülch KJ (1979) Histological typing of tumours ganglioglioma of the central nervous system. 1st ed. World • Neuroblastoma Health Organization, Geneva • Poorly differentiated and embryonal tumours • Glioblastoma Tumours of Neuroepithelial tissue –– Variants: • Astrocytic tumours –– Glioblastoma with sarcomatous compo- • Astrocytoma nent [mixed glioblastoma and sarcoma] –– fibrillary –– Giant cell glioblastoma –– protoplasmic • Medulloblastoma –– gemistocytic –– Variants: • Pilocytic astrocytoma –– desmoplastic medulloblastoma • Subependymal giant cell astrocytoma [ven- –– medullomyoblastoma tricular tumour of tuberous sclerosis] • Medulloepithelioma • Astroblastoma • Primitive polar spongioblastoma • Anaplastic [malignant] astrocytoma • Gliomatosis cerebri • Oligodendroglial tumours • Oligodendroglioma Tumours of nerve sheath cells • Mixed-oligo-astrocytoma • Neurilemmoma [Schwannoma, neurinoma] • Anaplastic [malignant] oligodendroglioma • Anaplastic [malignant] neurilemmoma [schwan- • Ependymal and choroid plexus tumours noma, neurinoma] • Ependymoma • Neurofibroma –– Myxopapillary • Anaplastic [malignant]neurofibroma [neurofi- –– Papillary brosarcoma, neurogenic sarcoma] –– Subependymoma • Anaplastic [malignant] ependymoma Tumours of meningeal and related tissues • Choroid plexus papilloma • Meningioma • Anaplastic [malignant] choroid plexus papil- –– meningotheliomatous [endotheliomatous, -
ACUTE APPENDICITIS Anatomy
ACUTE APPENDICITIS Anatomy • Embryologically, the appendix is a continuation of the cecum, first delineated during the fifth month of gestation • The appendix averages 10 cm in length (range 2‐20 cm). • The wall of the appendix consists of both an inner circular and an outer longitudinal layer of muscle. The longitudinal layer is a continuation of the taeniae coli. • The appendix is lined by colonic epithelium • Few submucosal lymphoid follicles are noted at birth. These follicles enlarge, peak between age 12 and 20 years, then decrease. Anatomy Anatomy • Blood supply from the appendicular artery, a branch of the ileocolic artery. This artery courses through the mesoappendix posterior to the terminal ileum. • An accessory appendicular artery can branch from the posterior cecal artery. • The appendix runs into a serosal sheet of the peritoneum called the mesoappendix Anatomy Anatomy • While the appendiceal base is in a constant location, the position of the tip of the appendix varies widely. • 65% of patients, the tip is located in a retrocecal position • 30%, it is located at the brim or in the true pelvis • 5%, it is extraperitoneal, situated behind the cecum, ascending colon, or distal ileum. Anatomy ETIOLOGY Appendicitis results from obstruction of the lumen of the appendix. o lymphoid hyperplasia (60%) o fecalith or fecal stasis (35%) o foreign body (4%) o tumors (1%) • Rarely non‐obstructive; vasculitis, Yersinia Obstructive causes Fecaliths form when calcium salts and fecal debris become layered around a nidus of inspissated fecal material located within the appendix. Lymphoid hyperplasia is associated with various inflammatory and infectious disorders including Crohn disease, gastroenteritis, amebiasis, respiratory infections, measles, and mononucleosis. -
Biomarkers for Determining Sensitivity of Breast
(19) TZZ ¥Z¥_T (11) EP 2 430 443 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: G01N 33/50 (2006.01) G01N 33/532 (2006.01) 27.06.2018 Bulletin 2018/26 G01N 33/533 (2006.01) G01N 33/535 (2006.01) G01N 33/543 (2006.01) G01N 33/574 (2006.01) (21) Application number: 10720095.8 (86) International application number: (22) Date of filing: 13.05.2010 PCT/US2010/034814 (87) International publication number: WO 2010/132723 (18.11.2010 Gazette 2010/46) (54) BIOMARKERS FOR DETERMINING SENSITIVITY OF BREAST CANCER CELLS TO HER2-TARGETED THERAPY BIOMARKER ZUR BESTIMMUNG DER EMPFINDLICHKEIT VON BRUSTKREBSZELLEN GEGENÜBER EINER AUF HER2 GERICHTETEN THERAPIE BIOMARQUEURS PERMETTANT DE DÉTERMINER LA SENSIBILITÉ DE CELLULES CANCÉREUSES DU SEIN À UN TRAITEMENT CIBLANT LE RÉCEPTEUR HER2 (84) Designated Contracting States: • KIRKLAND, Richard AL AT BE BG CH CY CZ DE DK EE ES FI FR GB San Diego GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO California 92111 (US) PL PT RO SE SI SK SM TR • LEE, Tani Designated Extension States: San Diego BA ME RS California 92117 (US) • YBARRONDO, Belen (30) Priority: 14.05.2009 US 178458 P San Diego 22.05.2009 US 180787 P California 92107 (US) 15.06.2009 US 187246 P • SINGH, Sharat 24.07.2009 US 228522 P Rancho Santa Fe 20.08.2009 US 235646 P California 92127 (US) 11.09.2009 US 241804 P 19.11.2009 US 262856 P (74) Representative: J A Kemp 30.11.2009 US 265227 P 14 South Square Gray’s Inn (43) Date of publication of application: London WC1R 5JJ (GB) 21.03.2012 Bulletin 2012/12 (56) References cited: (73) Proprietor: Pierian Holdings, Inc.