Dietary Interventions to Reduce Metabolic Syndrome in an Uninsured Population: an Evidence-Based Approach Michele Smith Bednarzyk University of North Florida

Total Page:16

File Type:pdf, Size:1020Kb

Dietary Interventions to Reduce Metabolic Syndrome in an Uninsured Population: an Evidence-Based Approach Michele Smith Bednarzyk University of North Florida UNF Digital Commons UNF Graduate Theses and Dissertations Student Scholarship 2009 Dietary Interventions to Reduce Metabolic Syndrome in an Uninsured Population: An Evidence-Based Approach Michele Smith Bednarzyk University of North Florida Suggested Citation Bednarzyk, Michele Smith, "Dietary Interventions to Reduce Metabolic Syndrome in an Uninsured Population: An Evidence-Based Approach" (2009). UNF Graduate Theses and Dissertations. 207. https://digitalcommons.unf.edu/etd/207 This Doctoral Project is brought to you for free and open access by the Student Scholarship at UNF Digital Commons. It has been accepted for inclusion in UNF Graduate Theses and Dissertations by an authorized administrator of UNF Digital Commons. For more information, please contact Digital Projects. © 2009 All Rights Reserved DIETARY INTERVENTIONS TO REDUCE METABOLIC SYNDROME IN AN UNINSURED POPULATION: AN EVIDENCED-BASED APPROACH by Michele Smith Bednarzyk A project submitted to the School of Nursing in partial fulfillment of the requirements for the degree of Doctor of Nursing Practice UNIVERSITY OF NORTH FLORIDA BROOKS COLLEGE OF HEALTH December, 2009 Certificate of Approval DATE Signature Removed <floC:' /1/~. i Y Signature Removed / / I i JQ41t~(:), Rodriguez Signature Removed Kathaleen C. Bloom, Committee Chair Signature Removed Lillia M. Loriz, Director, School ofNurs' Acc pt d for the Colle e: Signature Removed Pamela S. Chally, Dean, Brooks Col cc pted for the University: Signature Removed Mark . Workman, Provost and Vice President for Academic Affairs iii Acknowledgements Obviously a doctoral project is not possible without the support of numerous people. None of this would have been possible without the love and patience of my immediate family who has been a constant source of love, concern, support and strength all these years. I would like to thank my husband Paul for his emotional support and encouragement. Without his help, I would not be able to complete this project. I would like to express my heart-felt gratitude to my sister and family for their faith in me. My mother and father, along with my grandparents, showed me how to appreciate the need for education. My extended family has also aided and encouraged me throughout this endeavor. I have to give a special mention for the support given by Judy Rewis and Debi Wagner. I warmly appreciate their generosity and understanding. My deepest gratitude is to my advisor, Dr. Kathaleen Bloom. I have been fortunate to have an advisor and friend who gave me the freedom to explore my own ideas and at the same time provided me the advice and support to continue with this endeavor. Kathy taught me how to express ideas and learn to enjoy research. I am also thankful to her for encouraging the use of evidence based research and for carefully reading and commenting on countless revisions of this manuscript. My advisor and friend, Dr. Lillia Loriz, has been always there to listen and give advice. I am deeply grateful to her for the long discussions that helped me sort out the iv details of my work. Her patience and support helped me overcome many crisis situations and finish this project. Dr. Judy Rodriguez helped me focus my thoughts and the direction of this project. Her experience has been invaluable to me as a novice in dietary interventions. I am grateful for her encouragement and practical advice. I am also thankful to her for reading my chapters; commenting on my views and thus helping me reach my goals. Many people on the faculty and staff of the School of Nursing assisted and encouraged me in various ways during my course of studies. I am also grateful to the following former or current doctoral students at University of North Florida for their various forms of support during my graduate study, especially the original “first class”. I am especially thankful to Dr. Pam Chally and Dr. Lucy Trice who gave me the opportunity to fulfill my degree at UNF. I can say I received my degree from one of the best DNP programs in the county!! v Table of Contents Acknowledgements .......................................................................................................... iii List of Tables .................................................................................................................... vii List of Figures ................................................................................................................. viii Abstract ............................................................................................................................ ix Chapter One: ...................................................................................................................... 1 Problem .........................................................................................................................3 Treatment ......................................................................................................................6 Purpose ..........................................................................................................................6 Definition of Terms........................................................................................................7 Chapter Two: Literature Review .........................................................................................9 Search Strategies ...........................................................................................................9 Metabolic Syndrome and Cardiovascular Disease .....................................................10 General Treatment Strategies for Metabolic Syndrome .............................................16 Pharmacologic Measures for Treatment of Metabolic Syndrome ..............................18 Nonpharmacologic Measures for Treatment of Metabolic Syndrome .......................19 Chapter Three: Methodology .............................................................................................29 Study Design ...............................................................................................................29 Sample .........................................................................................................................30 Methods .......................................................................................................................30 Evaluation Plan ...........................................................................................................31 Protection of Human Subjects ....................................................................................33 Chapter Four: Results ........................................................................................................34 Demographic Data .......................................................................................................34 Comparison of Study Groups.......................................................................................36 Chapter Five: Conclusions .................................................................................................38 vi Discussion ...................................................................................................................38 Limitations ..................................................................................................................39 Conclusion ..................................................................................................................42 Appendices ........................................................................................................................45 Appendix A Critical Analysis Table: Review of the Evidence ................................45 Appendix B Data Collection Sheet ...........................................................................51 Appendix C Dietary Counseling Sessions ................................................................53 References .........................................................................................................................63 Curriculum Vitae ..............................................................................................................68 vii List of Tables Table 1.1 Criteria Proposed for Clinical Diagnosis of Metabolic Syndrome .....................4 Table 1.2 NHANES III Prevalence of Individual Metabolic Syndrome Abnormalities Among U.S. Adults by Disease Category ..........................................................5 Table 1.3 ATP III Clinical Identification of the Metabolic Syndrome ...............................7 Table 1.4 Nutrient Composition of the TLC Diet ................................................................8 Table 2.1 Characteristics of Cohort Studies of Metabolic Syndrome and Incidents of Cardiovascular Disease and Death ...................................................................11 Table 2.2 Risk factors for Chronic Heart Disease and their Association with Framingham Risk Scoring System and Metabolic Syndrome Diagnostic Criteria ...............15 Table 2.3 Therapeutic Lifestyle Diet in ATP III ...............................................................21 Table 2.4 Meta-Analysis Evaluation .................................................................................27 Table 4.1 Baseline Measures of Sample ...........................................................................35 Table 4.2 24-Hour Diet Recall ..........................................................................................35 Table 4.3 Study Group Mean Metabolic Syndrome
Recommended publications
  • Metabolic Syndrome
    Patient Guide Metabolic Syndrome Table of contents Metabolic Syndrome 01 Foods to eat & avoid 08 Overview Vegetables BMI Fruits / juices Legumes Grains Associated conditions 02 Protein Cardiovascular disease Sweeteners Polycystic ovarian syndrome Fats Fatty liver Other items to avoid Sleep apnea Type 2 diabetes Activities 11 Importance of exercise Contributing factors 03 Helpful exercise tips Inflammation Tips to reduce stress Nutrient deficiencies Dietary excess Lack of exercise Sample meal plan 12 Environmental toxin exposure Stress Recipes 13 Shakes Supplements 05 Breakfast MediBolic® Lunch & dinner Super EPA Pro Soups & stews Meriva 500-SF Salads Side dishes Snacks Diet 06 Desserts Modified Mediterranean Diet Glycemic index / load Carb count Health journal 27 Final word 28 Metabolic syndrome Overview Metabolic syndrome is a constellation of conditions that can result in one or more negative impacts on your heart, blood vessels, and liver, as well as your ability to metabolize sugar and fat. Also referred to as syndrome X or insulin resistance, it is estimated that 25% of the world’s adult population (and it is believed to be closer to 34% in the United States) has signs and symptoms associated with metabolic syndrome.1 While metabolic syndrome can seriously impact your health, there are steps that can be taken to reduce or reverse these potential negative health consequences. In this guide, you will learn about the potential causes of metabolic syndrome, what factors help determine a metabolic syndrome diagnosis, and what nutritional
    [Show full text]
  • Insulin Resistance in Gastroesophageal Reflux Disease
    REVIEW ARTICLE Insulin Resistance in Gastroesophageal Reflux Disease Laras Budiyani, Dyah Purnamasari, Marcellus Simadibrata, Murdani Abdullah Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Corresponding Author: Dyah Purnamasari, MD., PhD., Endocrinologist. Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital. Jl Salemba Raya No 6, Jakarta 10430, Indonesia. email: [email protected]. ABSTRAK Resistensi insulin merupakan gangguan dalam regulasi glukosa yang ditandai dengan peningkatan kadar insulin. Dalam konteks klinik, resistensi insulin dapat bermanifestasi sebagai sindrom metabolik yang memiliki risiko kejadian kardivaskular yang tinggi. Beberapa studi telah melaporkan bahwa resistensi insulin berhubungan langsung terhadap adanya esofagitis erosif pada pasien dengan penyakit refluks gastroesofageal (GERD). Dalam tinjauan pustaka ini, kami akan menelaah pemahaman terbaru yang dapat menjelaskan adanya resistensi insulin pada pasien dengan penyakit refluks gastroesofageal. Kata kunci: resistensi insulin, GERD, sindrom metabolik, esofagitis erosif. ABSTRACT Insulin resistance is the disturbance of glucose regulation characterized by higher insulin level. In clinical context, insulin resistance can manifest as abnormalities that are related with cardiovascular event risk, known as metabolic syndrome. Several studies had reported that insulin resistance was associated
    [Show full text]
  • Metabolic Syndrome: Past, Present and Future
    nutrients Editorial Metabolic Syndrome: Past, Present and Future Isabelle Lemieux 1,* and Jean-Pierre Després 1,2,3 1 Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec—Université Laval, Québec, QC G1V 4G5, Canada; [email protected] 2 Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada 3 VITAM—Centre de recherche en santé durable, CIUSSS de la Capitale-Nationale, Québec, QC G1J 0A4, Canada * Correspondence: [email protected]; Tel.: +1-418-656-8711 (ext. 3603) Received: 28 October 2020; Accepted: 29 October 2020; Published: 14 November 2020 1. Syndrome X: A Tribute to a Pioneer, Gerald M. Reaven Most clinicians and health professionals have heard or read about metabolic syndrome. For instance, as of October 2020, entering “metabolic syndrome” in a PubMed search generated more than 57,000 publications since the introduction of the concept by Grundy and colleagues in 2001 [1]. Although many health professionals are familiar with the five criteria proposed by the National Cholesterol Education Program-Adult Treatment Panel III for its diagnosis (waist circumference, triglycerides, high-density lipoprotein (HDL) cholesterol, blood pressure and glucose), how these variables were selected and the rationale used for the identification of cut-offs remain unclear for many people. In addition, the conceptual definition of metabolic syndrome is often confused with the tools (the five criteria) that have been proposed to make its diagnosis [2,3]. In the seminal paper of his American Diabetes Association 1988 Banting award lecture, Reaven put forward the notion that insulin resistance was not only a fundamental defect increasing the risk of type 2 diabetes, but he also proposed that it was a prevalent cause of cardiovascular disease [4].
    [Show full text]
  • Effects of Bariatric Surgery on the Metabolic Syndrome
    ABCDDV/779 ABCD Arq Bras Cir Dig Artigo Original 2011;24(2): 140-143 EFEITOS DA CIRURGIA BARIÁTRICA SOBRE A SÍNDROME METABÓLICA Effects of bariatric surgery on the metabolic syndrome Jimmy Ali Saadallah AYOUB, Paulino Alberto ALONSO, Ligia Maria Vaz GUIMARÃES Trabalho realizado no Complexo Hospitalar RESUMO - Racional - A obesidade mórbida é um estado de resistência à insulina associado Edmundo Vasconcelos, Departamento de ao excesso de gordura visceral, condições que contribuem para o desenvolvimento Gastrocirurgia, São Paulo, SP, Brasil da síndrome metabólica. Na obesidade, os tratamentos conservadores promovem melhora da síndrome metabólica, mas a recuperação de peso é frequente. A derivação gástrica em Y-de-Roux resulta em perda de peso, mais significativa e sustentada, além de promover melhora da síndrome metabólica, que é condição de risco para o desenvolvimento de doença aterosclerótica sistêmica. Objetivo - Demonstrar que a cirurgia bariátrica promove a reversão da síndrome metabólica. Métodos - O estudo foi realizado com 74 pacientes obesos, submetidos a derivação gástrica em Y-de- Roux por videolaparoscopia. Foram avaliados por meio de dados antropométricos e laboratoriais, com a aferição do peso, circunferência abdominal, índice de massa corporal, pressão arterial sistêmica e a dosagem de glicemia, triglicérides, colesterol total e sua fração HDL, no pré-operatório e ao longo de seis meses após a operação. Para comparação de médias foi utilizado o teste não paramétrico de Friedman e, quando necessário, o teste de Wilcoxon, considerando nível de significância valor de p<0,05. Resultados - Houve 52 mulheres e 22 homens, com a média de idade de 34,6 anos. O intervalo de seguimento foi de seis meses.
    [Show full text]
  • Metabolic Syndrome
    The IDF consensus worldwide de nition of the METABOLIC SYNDROME No part of this publication may be reproduced or transmitted in any form or by any means without the prior written permission of the International Diabetes Federation (IDF). Requests to reproduce or translate IDF publications should be addressed to: IDF Communications Avenue Emile De Mot 19, B-1000 Brussels, Belgium by fax at +32-2-5385114 or by e-mail at [email protected] © International Diabetes Federation, 2006 2 The IDF worldwide defi nition of the metabolic syndrome was developed during a unique consensus workshop on the initiative of Professors Sir George Alberti and Paul Zimmet. The workshop was held on behalf of the IDF Task Force on Epidemiology and Prevention. After the meeting, a writing group was convened including: Sir George Alberti, London, UK Paul Zimmet, Melbourne, Australia Jonathan Shaw, Melbourne, Australia Scott M. Grundy, Dallas, USA, Consultant to Writing Group The IDF metabolic syndrome consensus defi nition process (workshop) was supported by an educational grant from AstraZeneca Pharmaceuticals. AstraZeneca had no role in the development of the consensus defi nition, or in the review or approval of the manuscript. This publication has been funded by IDF. The IDF also gratefully acknowledges the contribution of: Pablo Aschner - Bogotá, Columbia Beverley Balkau - France Philip Barter - Sydney, Australia Peter Bennett - Phoenix, USA Edward Boyko - Seattle, USA John Brunzell - Seattle, USA Juliana Chan - Hong Kong, SAR China Ralph DeFronzo - San Antonio,
    [Show full text]
  • What Is Metabolic Syndrome?
    ANSWERS Cardiovascular Conditions by heart What Is Metabolic Syndrome? Metabolic syndrome is a group of five risk factors that can lead to heart disease, diabetes, stroke and other health problems. Metabolic syndrome is diagnosed when someone has three or more of these conditions: • High blood glucose (sugar) • Low levels of HDL (“good”) cholesterol in the blood • High levels of triglycerides in the blood • Large waist circumference or “apple-shaped” body • High blood pressure Although each of these is a risk factor for cardiovascular disease, when a person has three or more and is diagnosed with metabolic syndrome, it increases the Abdominal obesity and high blood pressure are two conditions chance of developing a serious cardiovascular condition. that contribute to metabolic syndrome. Who’s at risk for metabolic syndrome? How is it diagnosed? In recent years this syndrome has become much more Most of the conditions that make up metabolic syndrome common in the United States. Over 34% of U.S. adults have it. have no signs or symptoms. But a large waistline is a visible It’s also increasing globally. sign of being overweight or obese. Although some people are genetically prone to developing You are diagnosed with metabolic syndrome if you have metabolic syndrome, others get it as result of their lifestyle three or more of these conditions: or other factors. Several things that increase your risk of metabolic syndrome are: • Central or abdominal obesity. This is measured by waist circumference: • Obesity/overweight. Excessive fat in and around the – Men: greater than 40 inches abdomen (stomach) is most strongly associated with – Women: greater than 35 inches metabolic syndrome.
    [Show full text]
  • Fasting Insulin Level Changes After Large Volume Liposuction
    The Egyptian Journal of Hospital Medicine (July 2018) Vol. 73 (3), Page 6243-6251 Fasting Insulin Level Changes after Large Volume Liposuction Hanna Habib, Sarah Abd Alazeem, Nermin Abd Alazeem Department of General Surgery, Faculty of Medicine - Ain Shams University Corresponding author: Nermin A. Abdelaziz; Mobile: 01013613439; Email: [email protected] Abstract Background: Obesity is a disabling disease which has gained greater attention worldwide. It significantly increases the risk for other diseases such as insulin independent diabetes mellitus also known as diabetes type 2. The most common surgical procedure for obesity is liposuction. It is traditionally performed either as small-volume liposuction or large-volume liposuction. Aim of the Work: to spot the light on the effect of large volume liposuction on fasting insulin level changes after 3 months postoperative and to find if LVL may obtain any improvement in metabolic variables. This study will provide the clinician with a more valid basis on which to advise patients undergoing body- contouring procedures, particularly to ensure realistic expectations regarding the effects of body- reshaping procedures on general health. Patients and Mehtods: This is prospective study was conducted on a total of 15 overweight and obese (BMI 26–35 kg/m2) premenopausal women (age 21– 40years). All subjects were at their maximum body weight and weight stable for at least 3 months. The study took place at Ain Shams University Hospitals and other authorized hospitals under supervision of thesis supervisors studying fasting insulin changes after 3 months following large volume liposuction. Results: The present study demonstrates that large-volume abdominal liposuction should, by itself, be considered a clinical therapy for obesity and its metabolic sequelae.
    [Show full text]
  • Prevalence of Metabolic Syndrome in Children and Adolescents with Type 1 Diabetes Mellitus and Possibilities of Prevention and Treatment: a Systematic Review
    nutrients Review Prevalence of Metabolic Syndrome in Children and Adolescents with Type 1 Diabetes Mellitus and Possibilities of Prevention and Treatment: A Systematic Review Monika Grabia , Renata Markiewicz-Zukowska˙ * and Katarzyna Socha Department of Bromatology, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, Poland; [email protected] (M.G.); [email protected] (K.S.) * Correspondence: [email protected]; Tel.: +48-85-748-5469 Abstract: Overweight and obesity are an increasingly common problem, not only among the healthy population, but also in adolescents with type 1 diabetes (T1DM). Excess body weight is related to many cardiometabolic complications as well as a high risk of metabolic syndrome (MetS). The purpose of this systematic review is to provide a concise and critical overview of the prevalence of MetS in children and adolescents with T1DM and, ultimately, to discuss prevention and treatment options. The study was conducted in accordance with PRISMA guidelines. This review shows that, apart from the growing percentage of overweight and obese children and adolescents with T1DM (on average 20.1% and 9.5%, respectively), the problem of the increasing incidence of MetS (range from 3.2 to 29.9%, depending on the criteria used) is one of the most important phenomena of our time. One of the methods of prevention and treatment is a combined approach: changing eating Citation: Grabia, M.; Markiewicz-Zukowska,˙ R.; Socha, K. habits and lifestyle, but there are also reports about the beneficial effects of the gut microflora. Prevalence of Metabolic Syndrome in Children and Adolescents with Type Keywords: type 1 diabetes mellitus; pediatric diabetes; metabolic syndrome; obesity; children; 1 Diabetes Mellitus and Possibilities adolescents; nutrition; physical activity; lifestyle; microbiome of Prevention and Treatment: A Systematic Review.
    [Show full text]
  • Metabolic Effects of Bariatric Surgery
    R Corcelles and others Bariatric surgery 174:1 R19–R28 Review MANAGEMENT OF ENDOCRINE DISEASE Metabolic effects of bariatric surgery Ricard Corcelles1,2, Christopher R Daigle1 and Philip R Schauer1 Correspondence should be addressed 1Bariatric and Metabolic Institute, Cleveland Clinic, 9500 Euclid Avenue, M61 Cleveland, OH 44195, USA and to P R Schauer 2Department of Gastrointestinal Surgery, Institute of Digestive and Metabolic Diseases, Fundacio´ Clı´nic per a la Email Recerca Biome` dica, Hospital Clinic de Barcelona, Barcelona, Spain [email protected] Abstract Obesity is associated with an increased risk of type 2 diabetes, hypertension, dyslipidemia, cardiovascular disease, osteoarthritis, numerous cancers and increased mortality. It is estimated that at least 2.8 million adults die each year due to obesity-related cardiovascular disease. Increasing in parallel with the global obesity problem is metabolic syndrome, which has also reached epidemic levels. Numerous studies have demonstrated that bariatric surgery is associated with significant and durable weight loss with associated improvement of obesity-related comorbidities. This review aims to summarize the effects of bariatric surgery on the components of metabolic syndrome (hyperglycemia, hyperlipidemia and hypertension), weight loss, perioperative morbidity and mortality, and the long-term impact on cardiovascular risk and mortality. European Journal of Endocrinology (2016) 174, R19–R28 Introduction Obesity is an epidemic on the rise. The World Health also reached epidemic levels. The National Health and European Journal of Endocrinology Organization projects that by 2015, w2.3 billion adults Nutrition Examination Survey reported that 34% of will be overweight and more than 700 million will be American adults have metabolic syndrome based on the obese (1).
    [Show full text]
  • Unhealthy Lifestyle and the Risk of Metabolic Syndrome
    Journal of Mind and Medical Sciences Volume 5 | Issue 2 Article 12 2018 Unhealthy lifestyle and the risk of metabolic syndrome- the Romanian experience Angela Cozma Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4 th Department of Internal Medicine, Cluj-Napoca, Romania, [email protected] Adela Sitar-Taut Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 4 th Department of Internal Medicine, Cluj-Napoca, Romania Laura Urian Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Department of Hematology, Cluj- Napoca, Romania Adriana Fodor Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Clinical Center of Diabetes, Nutrition, Metabolic diseases, Cluj-Napoca, Romania Ramona Suharoschi University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Faculty of Food Science & Technology, Cluj- FNoapllooca,w Rthiomsa anndia additional works at: https://scholar.valpo.edu/jmms See nePxat pratge of for the addiCtionaradl aioutvhorasscular Diseases Commons, and the Nutritional and Metabolic Diseases Commons Recommended Citation Cozma, Angela; Sitar-Taut, Adela; Urian, Laura; Fodor, Adriana; Suharoschi, Ramona; Muresan, Crina; Negrean, Vasile; Sampelean, Dorel; Zdrenghea, Dumitru; Pop, Dana; Daniel, Leucuta; and Orasan, Olga Hilda (2018) "Unhealthy lifestyle and the risk of metabolic syndrome- the Romanian experience," Journal of Mind and Medical Sciences: Vol. 5 : Iss. 2 , Article 12. DOI: 10.22543/7674.52.P218229 Available at: https://scholar.valpo.edu/jmms/vol5/iss2/12 This Research Article is brought to you for free and open access by ValpoScholar. It has been accepted for inclusion in Journal of Mind and Medical Sciences by an authorized administrator of ValpoScholar. For more information, please contact a ValpoScholar staff member at [email protected].
    [Show full text]
  • The Impact of Body Mass Index and the Metabolic Syndrome on the Risk of Diabetes in Middle-Aged Men
    Diabetes Care Publish Ahead of Print, published online September 17, 2010 THE IMPACT OF BODY MASS INDEX AND THE METABOLIC SYNDROME ON THE RISK OF DIABETES IN MIDDLE-AGED MEN Running title: BMI, metabolic syndrome and diabetes risk Johan Ärnlöv, MD 1, 5, PhD, Johan Sundström, MD, PhD 2, 3; Erik Ingelsson, MD, PhD 1, 4; and Lars Lind, MD, PhD 2 1 Department of Public Health and Caring Sciences/Geriatrics, 2 Department of Medical Sciences, and 3 Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden; 4 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and 5 School of Health and Social Studies, Dalarna University, Falun, Sweden Correspondence to: Johan Ärnlöv, MD, PhD Emailo: [email protected], Submitted 17 May 2010 and accepted 10 September 2010. This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher- authenticated version will be available in a future issue of Diabetes Care in print and online at http://care.diabetesjournals.org. Copyright American Diabetes Association, Inc., 2010 BMI, metabolic syndrome and diabetes risk Objective: The existence of an obese sub-group, with a healthy metabolic profile and low diabetes risk, has been proposed. Yet, long term data is lacking. We aimed to investigate associations between combinations of body mass index (BMI)-categories and metabolic syndrome (MetS), and risk of type 2 diabetes in middle-aged men.
    [Show full text]
  • Does Abdominoplasty Intensify the Metabolic Effect of Bariatric Surgery?
    ORIGINAL ARTICLES IMAJ • VOL 22 • JUNE 2020 Does Abdominoplasty Intensify the Metabolic Effect of Bariatric Surgery? Lior Leibou MD1,4, Tomer Perlok MD1,4, Rivi Haiat Factor MD1,4, Eyal Leibovitz MD2, Jacob Frand MD1,4, Stav Leibou4, Dror Sadan MD1 and Mordechai Shimonov MD3,4 Departments of 1Plastic Surgery Unit, 2Internal Medicine, and 3Surgery A, Wolfson Medical Center, Holon, Israel 4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel ABSTRACT Background: The effect of weight reduction following bar- skeletal muscle, liver, kidney, and heart. Fat deposition can iatric surgery is already well known. be associated with several metabolic abnormalities including Objectives: To investigate the effects of abdominoplasty on altered adipokine profile, insulin resistance, and endothelial metabolic markers indicative of weight loss. dysfunction [5-7]. Leptin, the satiety hormone, is secreted by Methods: The authors prospectively enrolled consecutive adipocytes along with TNF-α, IL-6, resistin, and adiponectin, obese patients after laparoscopic sleeve gastrectomy. They and provides negative feedback at the hypothalamic-pituitary were candidates for post-bariatric surgery abdominoplasty. axis to modulate appetite and energy expenditure. Some litera- The authors measured metabolic markers one day prior to ture seems to suggest a link between inflammation and insulin surgery, 24 hours after, and 3 months following surgery. They resistance as well as obesity which all play a critical role in the recorded medical and demographic parameters. pathogenesis of human disease [8-10]. Leptin levels increase Results: Sixteen patients were recruited for participation in the as fat mass increases and vice versa. Other metabolic chang- study. Mean age was 47 years and 88% of the patients were fe- es reported include a decrease in subcutaneous fat which is male.
    [Show full text]