ZBTB48 Rabbit Polyclonal Antibody – TA344491 | Origene

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ZBTB48 Rabbit Polyclonal Antibody – TA344491 | Origene

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for TA344491 ZBTB48 Rabbit Polyclonal Antibody Product data: Product Type: Primary Antibodies Applications: WB Recommended Dilution: WB Reactivity: Human Host: Rabbit Isotype: IgG Clonality: Polyclonal Immunogen: The immunogen for anti-ZBTB48 antibody: synthetic peptide directed towards the N terminal of human ZBTB48. Synthetic peptide located within the following region: EPAGLEEEEVSRTLGLVPRDQEPRGSHSPQRPQLHSPAQSEGPSSLCGKL Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. Note that this product is shipped as lyophilized powder to China customers. Purification: Affinity Purified Conjugation: Unconjugated Storage: Store at -20°C as received. Stability: Stable for 12 months from date of receipt. Predicted Protein Size: 77 kDa Gene Name: zinc finger and BTB domain containing 48 Database Link: NP_005332 Entrez Gene 3104 Human P10074 Background: ZBTB48 contains 1 BTB (POZ) domain and 11 C2H2-type zinc fingers. It belongs to the krueppel C2H2-type zinc-finger protein family and binds to and regulates the J and/or S elements in MHC II promoter. Synonyms: HKR3; pp9964; ZNF855 Note: Immunogen Sequence Homology: Human: 100%; Dog: 79%; Pig: 79%; Horse: 79%; Rabbit: 79%; Guinea pig: 79% This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 ZBTB48 Rabbit Polyclonal Antibody – TA344491 Protein Families: Transcription Factors Product images: WB Suggested Anti-ZBTB48 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: 293T cell lysateZBTB48 is supported by BioGPS gene expression data to be expressed in HEK293T This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 2 / 2.

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TZAP Mutation Leads to Poor Prognosis of Patients † with Breast Cancer
medicina Article TZAP Mutation Leads to Poor Prognosis of Patients y with Breast Cancer 1, 2, 3 2, 1, Yu-Ran Heo z, Moo-Hyun Lee z, Sun-Young Kwon , Jihyoung Cho * and Jae-Ho Lee * 1 Department of Anatomy, School of Medicine, Keimyung University, Daegu 42601, Korea; [email protected] 2 Department of Surgery, School of Medicine, Keimyung University, Dongsan Medical Center, Daegu 42601, Korea; [email protected] 3 Department of Pathology, School of Medicine, Keimyung University, Dongsan Medical Center, Daegu 42601, Korea; [email protected] * Correspondence: [email protected] (J.C.); [email protected] (J.-H.L.); Tel.: +82-53-580-3838 (J.C.); +82-53-580-3833 (J.-H.L.); Fax: +82-53-580-3835 (J.C. & J.-H.L.) This article was previously presented on the Breast Cancer Symposium in San Antonio, Texas, USA, y on 4–8 Dec. 2018. These authors contributed equally to this work. z Received: 1 October 2019; Accepted: 8 November 2019; Published: 18 November 2019 Abstract: Background and Objectives: ZBTB48 is a telomere-associated factor that has been renamed as telomeric zinc ﬁnger-associated protein (TZAP). It binds preferentially to long telomeres, competing with telomeric repeat factors 1 and 2. Materials and Methods: We analyzed the TZAP mutation in 128 breast carcinomas (BCs). In addition, its association with telomere length was investigated. Results: The TZAP mutation (c.1272 G > A, L424L) was found in 7.8% (10/128) of the BCs and was associated with the N0 stage. BCs with the TZAP mutation had longer telomeres than those without this mutation.
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