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Download Special Issue BioMed Research International Inflammation in Muscle Repair, Aging, and Myopathies Guest Editors: Marina Bouché, Pura Muñoz-Cánoves, Fabio Rossi, Neuraland Dario ColettiComputation for Rehabilitation Inflammation in Muscle Repair, Aging, and Myopathies BioMed Research International Inflammation in Muscle Repair, Aging, and Myopathies Guest Editors: Marina Bouche,´ Pura Munoz-C˜ anoves,´ Fabio Rossi, and Dario Coletti Copyright © 2014 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “BioMed Research International.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Contents Inflammation in Muscle Repair, Aging, and Myopathies,MarinaBouche,´ Pura Munoz-C˜ anoves,´ Fabio Rossi, and Dario Coletti Volume 2014, Article ID 821950, 3 pages Stem Cell Transplantation for Muscular Dystrophy: The Challenge of Immune Response, Sara Martina Maffioletti, Maddalena Noviello, Karen English, and Francesco Saverio Tedesco Volume2014,ArticleID964010,12pages From Innate to Adaptive Immune Response in Muscular Dystrophies and Skeletal Muscle Regeneration: The Role of Lymphocytes, Luca Madaro and Marina Bouche´ Volume2014,ArticleID438675,12pages Cardioprotective Effects of Osteopontin-1 during Development of Murine Ischemic Cardiomyopathy, Georg D. Duerr, Bettina Mesenholl, Jan C. Heinemann, Martin Zoerlein, Peter Huebener, Prisca Schneider, Andreas Feisst, Alexander Ghanem, Klaus Tiemann, Daniela Dewald, Armin Welz, and Oliver Dewald Volume2014,ArticleID124063,15pages IL-6 Impairs Myogenic Differentiation by Downmodulation of p90RSK/eEF2 and mTOR/p70S6K Axes, without Affecting AKT Activity, Michele Pelosi, Manuela De Rossi, Laura Barberi, and Antonio Musaro` Volume 2014, Article ID 206026, 12 pages Local Overexpression of V1a-Vasopressin Receptor Enhances Regeneration in Tumor Necrosis Factor-Induced Muscle Atrophy, Alessandra Costa, Angelica Toschi, Ivana Murfuni, Laura Pelosi, Gigliola Sica, Sergio Adamo, and Bianca Maria Scicchitano Volume2014,ArticleID235426,14pages Influence of Immune Responses in Gene/Stem Cell Therapies for Muscular Dystrophies,AndreaFarini, Clementina Sitzia, Silvia Erratico, Mirella Meregalli, and Yvan Torrente Volume 2014, Article ID 818107, 16 pages Vitamin D Receptor Agonists: Suitable Candidates as Novel Therapeutic Options in Autoimmune Inflammatory Myopathy,ClaraCrescioli Volume2014,ArticleID949730,10pages 7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and RemodelingoftheSkeletalMuscleinaMouseModelofAntisynthetaseSyndrome, Clara Sciorati, Antonio Esposito, Lara Campana, Tamara Canu, Antonella Monno, Anna Palmisano, Francesco De Cobelli, Alessandro Del Maschio, Dana P. Ascheman, Angelo A. Manfredi, and Patrizia Rovere-Querini Volume 2014, Article ID 879703, 8 pages Understanding the Process of Fibrosis in Duchenne Muscular Dystrophy, Yacine Kharraz, Joana Guerra, Patrizia Pessina, Antonio L. Serrano, and Pura Munoz-C˜ anoves´ Volume 2014, Article ID 965631, 11 pages Inflammation Based Regulation of Cancer Cachexia, Jill K. Onesti and Denis C. Guttridge Volume2014,ArticleID168407,7pages Macrophage Plasticity in Skeletal Muscle Repair, Elena Rigamonti, Paola Zordan, Clara Sciorati, Patrizia Rovere-Querini, and Silvia Brunelli Volume 2014, Article ID 560629, 9 pages Hindawi Publishing Corporation BioMed Research International Volume 2014, Article ID 821950, 3 pages http://dx.doi.org/10.1155/2014/821950 Editorial Inflammation in Muscle Repair, Aging, and Myopathies Marina Bouché,1 Pura Muñoz-Cánoves,2 Fabio Rossi,3 and Dario Coletti4 1 DAHFMO,UnitofHistologyandMedicalEmbryology,SapienzaUniversityofRome,ViaAntonioScarpa14,00161Rome,Italy 2 Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Institucio´ Catalana de Recerca i Estudis Avanc¸ats (ICREA), Doctor Aiguader 88, 08003 Barcelona, Spain 3 The Biomedical Research Centre, UBC, Vancouver, BC, Canada V6T 1Z3 4 B2A Biology of Adaptation and Aging, Pierre and Marie Curie University (Paris 6), 7 quai St Bernard, 75252 Paris Cedex 5, France Correspondence should be addressed to Marina Bouche;´ [email protected] Received 17 July 2014; Accepted 17 July 2014; Published 4 August 2014 Copyright © 2014 Marina Bouche´ et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Numerous recent studies have expanded our knowledge on immune cell populations, their cross talk with other cell types the complexity of the immune system and its contribution within the muscle milieu, and their contribution to normal to skeletal muscle repair, aging, and myopathies. Indeed, it is versus pathological muscle repair. becoming clear that a precisely regulated cross talk between Among the seven review articles, E. Rigamonti et al. muscle and immune cells, involving endocrine/paracrine and discuss the current available literature about the role of cell-cell contact interactions, is required for muscle repair macrophage populations in tissue injury and repair with and maintenance of muscle homeostasis. Alterations of these a particular focus on skeletal muscle regeneration. Beyond mechanisms lead to unsuccessful repair in response to direct theirroleininnateimmunity,macrophagesarenowrecog- mechanical trauma (acute injury) or following secondary nizedascrucialplayersinorchestratingthehealingofvarious damage as a consequence of aging or genetic neuromuscular injured tissues, including skeletal muscle. In this review the defects. In fact, though the capacity of muscle to regenerate authors discuss the involvement of specific macrophage sub- relies primarily on a specific population of muscle stem cells, populations in these processes and the complexity of defining named satellite cells, the inflammatory cells that infiltrate macrophage subpopulations in vivo,sincethein vitro criteria the injured muscle appear to be as critical for successful used to define M1 and M2 macrophages cannot be strictly regeneration. Conversely, if damage persists, as in chronic applied to in vivo settings.Indeed,itisstillamatterofdebate myopathies, inflammatory cell infiltration is perpetuated and whether the sequential presence of different macrophage leads to progressive muscle fibrosis, thus exacerbating disease populations results from a dynamic shift in macrophage severity. polarization or from the recruitment of new circulating Whilethenumberofscientificpublicationsonthetopicof monocytes. Thus, to identify the molecular determinants of skeletal muscle inflammation has steadily grown over the last macrophage polarization is certainly one of the major tasks two decades, the notion of inflammation as a common feature in developing effective targeted therapies for genetic defects in muscle degeneration occurring in aging and myopathies of the tissue and muscle diseases associated with chronic and its association with altered muscle has to our knowledge inflammation. never previously been addressed and discussed in dedicated However, although macrophages are emerging as indis- journal issues before. pensable for damage control and tissue remodeling following Themainfocusofthisspecialissueistobringtogether muscle injury and as principal mediators of pathological studies that used different experimental approaches in vivo or skeletal remodeling in diseases such as idiopathic inflam- in vitro to dissect the dynamic changes taking place in specific matory myositis (IIMs) and muscular dystrophies (MDs), 2 BioMed Research International the involvement of other immune cells in promoting or muscles. Treatments for IIMs are based on lifelong immuno- preventing muscle damage resolution is also emerging. The suppressive therapy, which comes with well-known adverse current knowledge and recent advances on the involvement effects; recovery is incomplete for many patients. More effec- of different innate immune cells in MDs and the emerg- tive therapies, with reduced side effects, are highly desirable. ing role of additional cell populations within the acquired In this context, C. Crescioli proposes vitamin D receptor immune response are being discussed in the review article by (VDR) agonists as candidates in future treatment of IIMs. In L. Madaro and M. Bouche.´ her review she summarizes the pleiotropic anti-inflammatory It is widely believed that any disruption in the coordi- properties of VDRs with potentially limited adverse effects. nated initiation, progression, and resolution of inflammation Similarly, A. Costa et al., in one out of the four original can lead to persistent muscle damage and impairment of contributions in this issue, propose Arg-vasopressin- (AVP-) regeneration, which in many cases is also characterized by dependent pathways as an interesting strategy to counteract development of fibrosis, as observed in MDs. Indeed, the muscledeclineinagingormyopathies.Indeed,theauthors process of fibrosis, whose underlying mechanisms are not show that overexpression of the AVP receptor V1a in skeletal fully elucidated yet, represents one important deleterious muscle in vivo increases the expression of regenerative mark- consequenceofimpairedmusclerepair.Inthisspecial ers, modulates immune response, and attenuates
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