Prescription Drug Abuse Glossary and Resource Guide
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Abecarnil/Allobarbital 959 Pharmacopoeias
Abecarnil/Allobarbital 959 Pharmacopoeias. In Eur. (see p.vii). acamprosate’s action including inhibition of neuronal hyper- maleate in the treatment of anxiety disorders, hiccups, and nau- Ph. Eur. 6.2 (Acamprosate Calcium). A white or almost white excitability by antagonising excitatory amino acids such as sea and vomiting. Acepromazine, as the base, has also been giv- powder. Freely soluble in water; practically insoluble in alcohol glutamate. en in preparations for the management of insomnia. and in dichloromethane. A 5% solution in water has a pH of 5.5 1. Wilde MI, Wagstaff AJ. Acamprosate: a review of its pharmacol- Preparations to 7.0. ogy and clinical potential in the management of alcohol depend- ence after detoxification. Drugs 1997; 53: 1038–53. Proprietary Preparations (details are given in Part 3) Adverse Effects 2. Anonymous. Acamprosate for alcohol dependence? Drug Ther Denm.: Plegicil; Turk.: Plegicil. The main adverse effect of acamprosate is dosage-related diar- Bull 1997; 35: 70–2. Multi-ingredient: Fr.: Noctran. rhoea; nausea, vomiting, and abdominal pain occur less frequent- 3. Mason BJ. Treatment of alcohol-dependent outpatients with acamprosate: a clinical review. J Clin Psychiatry 2001; 62 (suppl ly. Other adverse effects have included pruritus, and occasionally 20): 42–8. a maculopapular rash; bullous skin reactions have occurred rare- 4. Overman GP, et al. Acamprosate for the adjunctive treatment of Aceprometazine (rINN) ly. Depression and fluctuations in libido have also been reported. alcohol dependence. Ann Pharmacother 2003; 37: 1090–9. Hypersensitivity reactions including urticaria, angioedema, and 5. Anton RF, et al. Combined pharmacotherapies and behavioral 16-64 CB; Aceprometazina; Acéprométazine; Aceprometazi- anaphylaxis have been reported very rarely. -
Smumedical Journal
SMU Medical Journal ISSN : 2349 – 1604 (Volume – 4, No. 1, January 2017) Review Article Indexed in SIS (USA), ASI (Germany), I2OR & i-Scholar (India), SJIF (Morocco) and Cosmos Foundation (Germany) databases. Impact Factor: 3.835 (SJIF) Analytical Aspects with Brief Overview of Depressants Sandeep Kumar1 Nand Gopal Giri2 Ashok Kumar Jaiswal3* Anil Kumar Jaiswal4 1M.Sc. (Forensic Science), LNJN NICFS, New Delhi 110085, 2Assistant Professor, Department of Chemistry, Shivaji College (University of Delhi) Raja Garden, New Delhi 110 027, 3Dept. of Forensic Medicine and toxicology, All India institute of Medical Sciences, New Delhi 110 029.4Assistant Professor, Department of Mathematics, St. Andrew’s PG College, Gorakhpur, UP. *Corresponding author Manuscript received : 30.10.2016 Manuscript accepted: 21.11.2016 Abstract Depressants are drugs that slow down the functions of the central nervous system (CNS). These drugs are used to reduce anxiety and insomnia without drowsiness. The depressants cause relaxed feeling if used in small quantity but cause unconsciousness, vomiting and even death if taken in high quantity. It affects concentration and coordination of a person by slowing down his/ her ability to respond in unexpected situations. These drugs are also attributed for their physiological and psychological effects, eventually in large dose it become lethal. The different 142 SMU Medical Journal, Volume – 4, No. – 1, January, 2017 physical and chemical features of some very often used depressants are discussed in this manuscript. Keyword: Depressant, TLC, UV spectroscopy, HPLC, GLC etc. Introduction The classical depressants are hypnotics (which induce sleep), most antianxiety medicine (diazepam or valium), muscle spasm prevent seizure, but these drugs rapidly develop dependence and tolerance which finally leads to coma and death, so use of these drugs is highly unsafe. -
Review Memorandum
510(k) SUBSTANTIAL EQUIVALENCE DETERMINATION DECISION SUMMARY ASSAY ONLY TEMPLATE A. 510(k) Number: k062165 B. Purpose for Submission: New device C. Measurand: Barbiturates D. Type of Test: Qualitative and semi-quantitative enzyme immunoassay E. Applicant: Ortho-Clinical Diagnostics, Inc. F. Proprietary and Established Names: VITROS Chemistry Products BARB Reagent VITROS Chemistry Products Calibrator 26 VITROS Chemistry Products FS Calibrator 1 VITROS Chemistry Products DAT Performance Verifiers I, II, III, IV and V G. Regulatory Information: 1. Regulation section: 21 CFR 862.3150, Barbiturates test system 21 CFR 862.3200, Clinical Toxicology Calibrator 21 CFR 862.3180, Clinical Toxicology Control 2. Classification: Class II, (reagent, calibrator) Class I, reserved (control) 3. Product code: DIS, DLJ and DIF 4. Panel: Toxicology (91) 1 H. Intended Use: 1. Intended use(s): See Indications for use. 2. Indication(s) for use: VITROS Chemistry Products BARB Reagent: For in vitro diagnostic use only. VITROS Chemistry Products BARB Reagent is used on VITROS 5,1 FS Chemistry Systems for the semi- quantitative or qualitative determination of barbiturates (BARB) in human urine using a cutoff of 200 ng/mL or 300 ng/mL. Measurements obtained with the VITROS BARB method are used in the diagnosis and treatment of barbiturates use or overdose. The VITROS Chemistry Products BARB assay is intended for use by professional laboratory personnel. It provides only a preliminary test result. A more specific alternative chemical method must be used to confirm a result with this assay. Gas Chromatograpy/Mass Spectrometry (GC/MS) is the preferred confirmatory method. Clinical consideration and professional judgment should be applied to any drug-of-abuse test result, particularly when evaluating a preliminary positive result. -
Simultaneous Rapid HPLC Determination of Anticonvulsant Drugs in Plasma and Correlation with EMIT®
ANNALS OF CLINICAL AND LABORATORY SCIENCE, Vol. 10, No. 1 Copyright© 1980, Institute for Clinical Science, Inc. Simultaneous Rapid HPLC Determination of Anticonvulsant Drugs in Plasma and Correlation with EMIT® RAYMOND S. RYDZEWSKI, M.S., RICHARD H. GADSDEN, P h .D.,* and CONSTANCE A. PHELPS, A.S.M.T. Division of Clinical Chemistry, Department of Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403 ABSTRACT A method is presented for measuring simultaneously five anti-convulsants (primidone, ethosuximide, phénobarbital, carbamazepine and diphenyl- hydantoin) in serum and plasma by high-performance liquid chroma tography (H PLC) usingalphenal (5 - allyl - 5 - phenyl - barbituric acid) as the internal standard. All five drugs are separated from each other and, in the case of primidone, from its metabolite, 2 - phenyl - 2 - ethyl - malondiamide. Total HPLC time for the separation is seven minutes. The chromatography is performed on a C-8 reverse phase column with a mobile phase consisting of acetonitrile/phosphate buffer (35/65) at 25°C. The eluted drugs are detected at 220 nm and quantitated from their peak heights relative to that of the internal standard. The lower limits of detection for each drug is 200 ng per ml for primidone, 1000 ng per ml for ethosuximide, 200 ng per ml for phéno barbital, 100 ng per ml for carbamazepine and 200 ng per ml for diphenyl- hydantoin. Analytical recoveries for the five drugs ranged from 97 to 107 percent. Correlation of results for 187 specimens by enzyme-immunoassay (EMIT) was 0.981 for primidone, 0.827 for ethosuximide, 0.975 for phéno barbital, 0.889 for carbamazepine and 0.990 for diphenylhydantoin. -
Georgia State Forensic Drugs
Comprehensive Forensic FT-IR Collection Library Listing – 4,286 spectra This extensive library contains materials not only of forensic interest but also for general problem solving and identification of unknown substances in industry and academia. The wide range of items include drugs, clandestine lab chemicals, explosives, paints, fabrics, dyes, polymers, inorganic compounds, pigments, adhesives, and other common materials. The library consists of 4,286 spectra that were acquired from a wide range of laboratories involved in forensic investigations. The collection includes the following classes of compounds: • Drugs of abuse, scheduled materials • Pharmaceuticals, vitamins and excipients • Clandestine lab materials and intermediates • Solvents, organic chemicals and hazardous chemicals • Accelerants • Lubricants and natural oils • Explosives, pyrotechnics, primers, powders and boosters • Herbal and plant material and fibers • Automobile paint vehicles, pigments, primers and clear coats • Textiles, natural and man-made fibers, carpet materials • Paints, coatings, varnishes, oils • Dyes and stains • Polymers, monomers, copolymers, plasticizers and rubbers • Inorganics, pigments, minerals and clays • Tape, adhesives, sealants, glues, caulks and putties • Crystal test derivatives and intermediates • Household chemicals, cleaning agents, surfactants and pesticide All spectra were measured using micro or macro Diamond ATR, thin films on salt windows or KBr pellets at 4 cm-1 spectral resolution. Comprehensive Forensic FT-IR Collection Index -
FOOD and DRUGS Is Composed of Nine Volumes
Food and Drugs of 21 code PART 1300 TO END Revised as of April 1, 1996 CONTAINING A CODIFICATION OF DOCUMENTS OF GENERAL APPLICABILITY AND FUTURE EFFECT AS OF APRIL 1, 1996 regulations With Ancillaries Published by the Office of the Federal Register National Archives and Records Administration as a Special Edition of the Federal Register federal VerDate 20<JUN>96 10:04 Jul 12, 1996 Jkt 167073 PO 00000 Frm 00001 Fmt 8091 Sfmt 8091 C:\CFR\21V9.FRT pfrm13 1 U.S. GOVERNMENT PRINTING OFFICE WASHINGTON : 1996 For sale by U.S. Government Printing Office Superintendent of Documents, Mail Stop: SSOP, Washington, DC 20402±9328 VerDate 20<JUN>96 10:04 Jul 12, 1996 Jkt 167073 PO 00000 Frm 00002 Fmt 8092 Sfmt 8092 C:\CFR\21V9.FRT pfrm13 ?ii Table of Contents Page Explanation ................................................................................................ v Title 21: Chapter IIÐDrug Enforcement Administration, Department of Jus- tice .................................................................................................. 3 Chapter IIIÐOffice of National Drug Control Policy .......................... 271 Finding Aids: Table of CFR Titles and Chapters ....................................................... 325 Alphabetical List of Agencies Appearing in the CFR ......................... 341 List of CFR Sections Affected ............................................................. 351 iii VerDate 20<JUN>96 10:04 Jul 12, 1996 Jkt 167073 PO 00000 Frm 00003 Fmt 8092 Sfmt 8092 C:\CFR\21V9.FRT pfrm13 Cite this Code: CFR To cite the regulations in this volume use title, part and section num- ber. Thus, 21 CFR 1301.01 refers to title 21, part 1301, section 01. iv VerDate 20<JUN>96 10:04 Jul 12, 1996 Jkt 167073 PO 00000 Frm 00004 Fmt 8092 Sfmt 8092 C:\CFR\21V9.FRT pfrm13 Explanation The Code of Federal Regulations is a codification of the general and permanent rules published in the Federal Register by the Executive departments and agen- cies of the Federal Government. -
Economic and Social Council 1 November 2010
* United Nations E/CN.7/2010/21 Economic and Social Council 1 November 2010 Original: English Commission on Narcotic Drugs Reconvened fifty-third session Vienna, 2 December 2010 Agenda item 5 Improving the collection, reporting and analysis of data to monitor the implementation of the Political Declaration and Plan of Action on International Cooperation towards an Integrated and Balanced * Strategy to Counter the World Drug Problem Annual report questionnaire: Part Three. Extent and patterns of and trends in drug use∗∗ Note by the Secretariat Pursuant to Commission on Narcotic Drugs resolution 52/12, a meeting of the expert group on data collection was held in Vienna from 12 to 15 January 2010 to review the current data collection tools and collection, collation, analysis and reporting processes. Pursuant to Commission decision 53/2, the Secretariat produced a revised version of the draft annual report questionnaire; the expert group held a meeting in Vienna from 11 to 13 October 2010 to finalize the questionnaire so that the Commission could adopt it at its reconvened fifty-third session. The Secretariat hereby transmits part three of the questionnaire; parts one, two and four will be made available in separate documents (E/CN.7/2010/19, E/CN.7/2010/20 and E/CN.7/2010/22). __________________ * Reissued for technical reasons on 30 January 2012. ∗∗ The present document was submitted after the date required by the 10-week rule as the meeting of the expert group on data collection was held from 11 to 13 October 2010. V.10-57492* (E) *1057492* E/CN.7/2010/21 Annual report questionnaire Part Three. -
Forensic Toxicology Scope of Testing and Detection Limits
J. RYAN MCMAHON II County Executive INDU GUPTA, MD, MPH MEDICAL EXAMINER’S OFFICE Commissioner of Health FORENSIC TOXICOLOGY LABORATORY CAROLYN H. REVERCOMB, MD, DABP ONONDAGA COUNTY HEALTH DEPARTMENT Chief Medical Examiner KRISTIE BARBA, MS, D-ABFT-FT CENTER FOR FORENSIC SCIENCES Toxicologist Forensic Toxicology Scope of Testing and Detection Limits Table of Contents QUALITATIVE ANALYSES.........................................................................................................2 Volatile Screen by GC/FID .............................................................................................................2 Carbon Monoxide by Microdiffusion..............................................................................................2 Carbon Monoxide by CO-Oximeter ................................................................................................2 Ethylene Glycol by GC/MS.............................................................................................................2 ELISA Buprenorphine by IA for Blood/Urine ................................................................................2 ELISA by IA for Blood ...................................................................................................................3 ELISA by IA for Urine....................................................................................................................4 Gamma Hydroxybutyrate (GHB) by GC/MS..................................................................................5 Gabapentin, -
Guidelines for Responsible Opioid Prescribing in Chronic Non-Cancer Pain: Part 2 - Guidance
Pain Physician 2012; 15:S67-S116 • ISSN 1533-3159 ASIPP - Opioid Guidelines 2012 American Society of Interventional Pain Physicians (ASIPP) Guidelines for Responsible Opioid Prescribing in Chronic Non-Cancer Pain: Part 2 - Guidance Laxmaiah Manchikanti, MD1, Salahadin Abdi, MD, PhD2, Sairam Atluri, MD3, Carl C. Balog, MD4, Ramsin M. Benyamin, MD5, Mark V. Boswell, MD, PhD6, Keith R. Brown, PharmD7, Brian M. Bruel, MD8, David A. Bryce, MD9, Patricia A. Burks, LPT10, Allen W. Burton, MD11, Aaron K. Calodney, MD12, David L. Caraway, MD13, Kimberly A. Cash, RT14, Paul J. Christo, MD15, Kim S. Damron, RN16, Sukdeb Datta, MD17, Timothy R. Deer, MD18, Sudhir Diwan, MD19, Ike Eriator, MD20, Frank J.E. Falco, MD21, Bert Fellows, MA22, Stephanie Geffert, MLIS23, Christopher G. Gharibo, MD24, Scott E. Glaser, MD25, Jay S. Grider, DO, PhD26, Haroon Hameed, MD27, Mariam Hameed, MD28, Hans Hansen, MD29, Michael E. Harned, MD30, Salim M. Hayek, MD, PhD31, Standiford Helm II, MD32, Joshua A. Hirsch, MD33, Jeffrey W. Janata, PhD34, Adam M. Kaye, PharmD35, Alan D. Kaye, MD, PhD36, David S. Kloth, MD37, Dhanalakshmi Koyyalagunta, MD38, Marion Lee, MD39, Yogesh Malla, MD40, Kavita N. Manchikanti, MD41, Carla D. McManus, RN, BSN42, Vidyasagar Pampati, MSc43, Allan T. Parr, MD44, Ramarao Pasupuleti, MD45, Vikram B. Patel, MD46, Nalini Sehgal, MD47, Sanford M. Silverman, MD48, Vijay Singh, MD49, Howard S. Smith, MD50, Lee T. Snook, MD51, Daneshvari R. Solanki, MD52, Deborah H. Tracy, MD53, Ricardo Vallejo, MD, PhD54, Bradley W. Wargo, DO55 Results: From: American Society Part 2 of the guidelines on responsible opioid prescribing provides the following recommendations for of Interventional Pain initiating and maintaining chronic opioid therapy of 90 days or longer. -
Applicability of Biochip Array Technology to the Simultaneous Screening of a Broad Range of Drugs in Whole Blood
APPLICABILITY OF BIOCHIP ARRAY TECHNOLOGY TO THE SIMULTANEOUS SCREENING OF A BROAD RANGE OF DRUGS IN WHOLE BLOOD Randox Toxicology Ltd, 55 Diamond Road, Crumlin, Co Antrim BT29 4QY, United Kingdom e-mail: [email protected] Introduction Methodology Drug detection involves initial screening of samples for drugs. The screening Drugs of Abuse Ultra Array: Test menu procedure eliminates all negatives and positive results require confirmation using Amphetamine Meprobamate confirmatory methods. A multi-analytical approach, enabling the simultaneous Barbiturates Methamphetamine screening of drugs, would be advantageous to consolidate testing and increase Benzodiazepines 1 Methadone screening capacity during the drug testing process. Biochip array technology Benzodiazepines 2 Opiates enables the simultaneous detection of multiple analytes from a single sample. Buprenorphine Oxycodone 1 This study reports the applicability of a biochip array to the multiplex screening Cannabinoids Oxycodone 2 of a broad range of drugs in human whole blood, which increases the detection Cocaine metabolite (Benzoylecgonine) Phencyclidine capacity in testing settings. Dextromethorphan Tramadol Fentanyl Tricyclic antidepressants (TCAs generic) Generic Opioids Zolpidem Results Specificity/Cross-reactivity (CR) Amphetamine assay Methamphetamine assay Benzodiazepines 1 assay 1 2 3 4 5 Compound CR >20% Compound CR >20% Compound CR >20% 6 7 8 9 10 S(+)-Amphetamine* S(+)-Methamphetamine* Oxazepam* 11 12 13 14 15 16 17 18 19 20 (±)-MDA PMMA HCl Temazepam -
Perspectives in Drug Discovery a Collection of Essays on the History and Development of Pharmaceutical Substances
Perspectives in Drug Discovery A Collection of Essays on the History and Development of Pharmaceutical Substances Professor Alan Wayne Jones Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine Perspectives in Drug Discovery A Collection of Essays on the History and Development of Pharmaceutical Substances Professor Alan Wayne Jones Department of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine Perspectives in Drug Discovery A Collection of Essays on the History and Development of Pharmaceutical Substances Professor Alan Wayne Jones Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine Artillerigatan 12 • SE-587 58 Linköping • Sweden E-mail: [email protected] Internet: www.rmv.se RMV-report 2010:1 ISSN 1103-7660 Copyright © 2010 National Board of Forensic Medicine and Professor Alan Wayne Jones Design and graphic original: Forma Viva, Linköping • Sweden Printed by Centraltryckeriet, Linköping • Sweden, October 2010 Contents Preface Introduction 1. The First Sedative Hypnotics . 13 2. The Barbiturates ......................... 19 3. The Benzodiazepines ..................... 25 4. Narcotic Analgesics . 31 5. Central Stimulant Amines . 39 6. The First Antidepressants .................. 45 7. Antipsychotic Medication ................. 51 8. Aspirin and Other NSAID .................. 59 9. General Anesthetics . 65 10. SSRI Antidepressants . 71 11. Histamine Antagonists .................... 79 12. Anticonvulsants ......................... 87 -
Review Memorandum
510(k) SUBSTANTIAL EQUIVALENCE DETERMINATION DECISION SUMMARY ASSAY ONLY TEMPLATE A. 510(k) Number: k092268 B. Purpose for Submission: New assay C. Measurand: Barbiturates D. Type of Test: Homogeneous enzyme immunoassay – qualitative and semi- quantitative E. Applicant: Randox Laboratories Ltd. F. Proprietary and Established Names: Randox Barbiturates assay Randox Multidrug Calibrator Set Randox Multidrug Controls, Levels 1 and 2 G. Regulatory Information: 1. Regulation section: Product Code Classification Regulation Section Panel DIS Class II 21 CFR § 862.3200, 91-Toxicology Barbiturate test system DLJ Class II 21 CFR § 862.3200, 91-Toxicology Calibrators, Drug specific LAS Class I, reserved 21 CFR 862.3280 91-Toxicology Clinical Toxicology control material 1 H. Intended Use: 1. Intended use(s): See Indications for use below. 2. Indication(s) for use: Randox Barbiturates Assay: The Randox Laboratories Ltd. Barbiturates Assay is an in vitro diagnostic test for the detection of Barbiturates, in human urine on the Rx Imola and Rx Daytona. The cutoff for secobarbital is 200 ng/mL. This in vitro diagnostic device is intended for prescription use only. The semi-quantitative mode is for purpose of (1) enabling laboratories to determine an appropriate dilution of the specimen for confirmation by a confirmatory method such as GCMS Or (2) permitting laboratories to establish quality control procedures. This assay provides only a preliminary analytical result. A more specific alternative chemical method must be used in order to obtain a confirmed analytical result. Gas chromatograph/mass spectrometry (GC/MS) is the preferred confirmatory method. Clinical consideration and professional judgment should be exercised with any drug of abuse test result, particularly when the preliminary result is positive.