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PRIVACY ACT MATERIAL REMOVED SECTION I REVIEW CROUP Lype PROCRAM CRANT NUMBER (Insert on A11 Pi DEPARTMENT of HEALTH, EDUCATION PRIVACY ACT MATERIAL REMOVED SECTION I REVIEW CROUP lYPE PROCRAM CRANT NUMBER (Insert on a11 pi DEPARTMENT OF HEALTH, EDUCATION. AN0 WELFARE GMA 5 R01 AM - 17862-02 APPLICATION from: 10/01/74 nrouh: 9/3 0/7 7 FOR CONTINUATION GRANT REQUESTEO BUOCET PERIOD fmm: 1010 1/74 nmugh: 9/3 0176 2A. PRiNCIPAl INVLSTlGATOR OR PROGRAM OlREClOR 4. APPLICANT ORCMIZITION O(me rnd Address-Street, City. State. Zlp Code) (Name and Address. Street, City. State. Zip Code1 .. Klein Peter- D. The University o€ Chicago Argonne National Laboratory 5801 S. Ellis Avenue 9700 S. Cass Avenue Chicagd, Illinois 60637 Argonne, Illinois 60439 28. DEGREE ZC. SOCIAL SECURITY NOl - 5. Pns ACCOUNT NUMBER -PhD 1362177139Al 20. OEPLRlMENT. SE RVICE. LABORATORY OR EQUIVALENT 6. TITLE AN0 AOORESS Of OFFICIAL IN BUSINESS OffICE Of APPLICANT None ORWNlZATlOW 2E. MAJOR SUBOIVISION Assistant Vice President & Director, Argonne National Laboratory OCfice OE Sponsored Programs 3. ORCANIZATIONAl COMPONLNT TO RECEIVE CREDIT FOR INSTITUTIONAL University OF Chicago GRANT PURPOSES 5801 S. Ellis Avenue 20 Other I Chicago, Illinois 60637 7. RESEARCH INVOLVING HUMAN SUBJECTS (See InStruCtiOnr) 8. tNvLNTJONS (See Instructions) 8/6/74 (Current approva; M No 0 Yes-not previously reportsd 0 No Yes APPROVED: __- Oat* pending) 0 Yer.preriously rrparted 9. PERFORMANCE SlTE(S) TELLPHONE lNfC UTION Division of Biological and 11A. PRINCIPAL INVESTIGATOR Medical Research OR Argonne National Laboratory ROCRAM OlREtTOR (Item 211 9700 S. Cass Avenue Ext. 2811 Argonne, Illinois 60439 Ill. Narm of business offieid (Item 6) Cedric L. Chernick 312 I 753-3080 1IC. Nrma ad title 01 rdminirtratire oflicial (ltm 1%) 10. OIRECT COSTS 9EPUESTED TOR OUDGET PERIOD $63,439 (Includes indirect cost of $11 .SI? See items 6 & 11B 121. CONGRESSIONAL DISTRICT Of APPllCANl OR&NlZATlON SHOWN IN ITEM 4 121. COUNIY OF APPLICANT ORGANIZATION SHOWN IN ITEM 4 1st Cook I. &#'" -1- ;3 i y& -&-;.I /q7$- accept. as lo any grant awardcd. the obligation to comply with Public Health Service terms and condition3 in effect at the time of the award. 1'5. SICMATURES (Signalurer required on original - COPY only. Use Ink "Per" fig. 158. OFflClAL SICNINC FOR APPLICANT ORCANIZATION OATL nalures not acceptrDle.) -.___ '-?e:$.;*;c: v .- LI &J FROM THROUGH GRANT NUMBER SECTION il-BUDGET (USUALLY 12 MONTHS) 10/01/74 9/30/76 AM - 17862-02 - PERSONNEL TIME OR FRINGE BENEFITS . EffORT REQUESTED TOTAL NAME (Last. First. Initial) TITLE OF POSITION XIHRS. (b) (C) (1) (Indicate cost of each Item listed below) TOTAL (Columns (d) and (e) -I CONSULTANT COSTS (See Instruction$) I t OOMESTiC $ TRAVEL FOREIGN $ I I PATIENT COSTS (See instructions) . $ UTERATIONS AND RENOVATIONS $ Funds to be made available to Argonne National Laboratory See Page 2A €or Details INDIRECT - --X SLW' Date of DHEW Asreant: 0 Not Rquested COST --x TOC' 0 Under nrgotlrtlon with: (See' Instructions) 'If this is a special rats (e.r. offdte). atplain. PRIVACY ACT MATERIAL REMOVED BUDGET FOR CONTINUATION GRANT NO. AM - 17862-02 FROM 10/01/75 THROUGH 9/30/76 PERSONNEL Salary Frinqe Name. -Title E€€ort Requested Benefits TOTAL Klein, Peter D. Principal Investigator 10% $ $ Hachey, David L. Ass is tant Chemist 25% $ $ Szczepanik, Patricia A. Scientific Associate 25% $ $ Mede, Karin A. Research Associate* 100% $ $ Tserng , Kou-Yi Research Associate* 100% $ $ *Temporary stafE position See attached page for Argonne costing procedures Total personnel cost includes $11 , 5 13 in indirect costs €or permanent positions Subtotals $51,569 $4,870 TOTAL $56,439 ?-. SUPPLIES Glassware , gas chromatographic supports , coatings , compressed gases, filaments , electron multipliers, paper for viscicorder and line printers $3,000; intermediates and isotopes for stable isotoptcally labeled bile acid $2,000. $ 5,000 TRAVEL Quarterly trips , Chicago/Mayo (4 x $1501, Am. SOC. Mass. Spectrom. , AASLD $ 1,000 OTHER EXPENSES x= Photocopying , postage, page charges , reprints Funds to be made available to ANL $ 1,000 a L -c TQTAL DIRECT COST $63,439 2 00 ARGONNE NATIONAL LABORATORY Costing Procedures c Argonne's costing procedures are based on the assumption that all costs incurred will be recovered. The cost of work €or other Federal agencies is charged on the same basis as work €or ERDA program activities. The procedure is applied through- -out the Laboratory on a consistent basis and uses standard rates. The standard rates are an average oC base wages, fringe costs, divisional program direction, divisional general expenses and Laboratory indirect cost charged to the effort incurred within each scientfCic division. A standard rate is developed for each major payroll classification within the Division. Standard rates are reviewed periodically and revised as necessary. All labor cost is distributed within the Division using the standard rates mentioned above. The fringe costs include payroll related items such as annuities, social security and hospital and medical payments. The Division General, Program Direction, and Laboratory Overhead accounts include costs which cannot be charged to a specific program activity directly. Consistent with the procedure for costing work for ERDA, no depreciation of ERDA added cost factor is added to work €or other Federal agencies. The ANL monthly rates estimated €or the period ol this grant are as follows: 1. Sta€f Regular $1770 Fringe (17.7%) 313 Ind irect expense 1599 Total, Staff Regular $3652 2. Staff TeFporary $1138 Fringe (9.3%) 109 Total, Staff Temporary $1247 PACE 3 R c .I. 8- 7 7 1 i SECTION Ill-FISCAL DA,.. FOR FROM THROUGH GRANT NUMBER CURRENT BUDGET PERIOD 10/0 1/74 9/30/75 AM - 17862-01 (USUALLY 12 MONTHS) ACTUAL ESTIMATED EXPENDITURES ADDITIONAL TOTAL ESTIMATED ESTIMATED CURRENT UNOBLIGATED BUDGEl BAUNCE A BUDGET CATEGORIES (As approved by REMAINDER (Subtract Col. 4 awarding unit) (Insert Date) OF CURRENT COl. 3) from Cot. 1) BUDGET PERIOD (1) (5) Personnel (Salaries) Fringe %enofits Consultant Costs ~ Equipment Supplies Oomlrtlc TRAVEL Patient Casb Altentlons and Renovations Other $66.255 $22,015 I $44,240 I $66,255 -0- Total Direct Casts $66,255 $22.015 I $44,240 I $66,255 - 3- lndimt Costs (If Included in award) -0- -0- 1 -0- I -0- ~ -0- TOTALS * $66,255 t 22,015 f 44,240 $66,255 i -0- Use swm below to: 8. List all items of equipment purchased of expected to be purchased during this budget period which have a Unit cost of SlDOo of morr C. Explain rny significant balance or deficit shown in any category of Column 5. D. List all other research support for Principal Inmitigator by souru. project title. and annual amount. See Page 4A For Detail. - --- NIH 2006-1 (Formerly PHS 2590-1) PACE 4 (Use Conttnunton Pager as necessary) Rev. 8-73 FISCAL DATA FOR GRANT NO. AM - 17862-02 FOR CURRENT BUDGET PERIOD FROM lO/O 1/74 THROUGH 9/30/75 Est imated Additional Expenditures and Actual Obligations €or Expenditures Remainder Total Estimated Estimated &rent Thru o€ Current Expend iture s Unobligated Budqet Cateqories Budget 6/30/75 Budget Period And Obligations Balance Personnel (Salaries) $50,642 $17,634 $33 ,008 $50,642 $ -0- Fringe Benefits 4,613 1,765 2,848 4,613 -0- Equ i pmen t 4,000 -0- 4,000 4,000 -0- . Supplies 5 ,000 1,872 3,128 5,000 -0- Travel 1, 000 744 256 1,000 -0- Other 1,000 -0- 1,000 1, 000 --0- Total Direct Costs 66,255 22,015 44,240 66,255 -0- TOTALS $66,255 $22,015 $44,240 $66,255 $ -0- Equ i Dmen t purchases 1. Computer inter€ace €or PDP-12 to drive Biospect mass spectrometer €or spectra acquisition and multiple ion monitoring: constructed by Electronics Division, ANL. Cost $2,000. Installation being completed. 2. Modi€ication o€stable isotope ratiometer to provide intergrals of ion intensity; construction and installation by Electronics Division, ANL. Cost $1,900. 3. Pumping system €or liquid chromatograph, to be purchased. Cost $4,000. Budget balances None Research Support €or Principal Investigator The remaining 90% of the PI'S support is derived at present €rom the Energy Research and Development Administration. Funding from an Ancillary Study to the National Cooperative Gallstone Study to cover 10% f?? his time is awaiting contract negotiation and award. 0 0 c -J -00 Page 4P. APPLICANT: wtw GRANT NUMBER SHOWN ON PACE 1 ,-) CUTNUMBER SECTION IV-SUMMARY PROGRESS REPORT AM 17862-01 PRINCIPAL INVESTIGATOR OR PROGRAM DIRECTOR (Last. flrst. Inillal) PERIOD WVfRED BY THIS REPOdT Klein, Peter D. fROM THROUGM NAME OF ORGANIZATION Argonne National Laboratory 10/01/75 09/30/76 1. List publlutions: (8) published and not pnviously reportadd; (b) in press. Provido fiw rrerints It not prOViOUSly submitted. 2. List 811 additions 8nd drlotions in profersion8i pononnri and any changrs in offort. .. 3. Progross Rapor(. (Sea Instructions) PAPERS AM) ABSTRACTS SUPPORTED BY AM 17862-01 (October 1, 1974-September 30, 1975) Klein, P. D., J. R. Haumann and D. L. Hachey A stable isotope ratiometer-multiple ion detector (SIRMID) unit for quantitative and qualitative stable isotope studies by gas chromatography-mass spectrometry. Clinical Chemistry, in press, August issue. Szczepanik, P. A., D. L. Hachey and P. D. Klein Characterization of bile acid methyl ester acetate derivatives using gas-liquid chromatography, electron impact and chemical ionization mass spectrometry. Manuscript submitted to Journal of Lipid Research. Hachey, D. L., P. A. Szczepanik, J. B. Watkins, A. M. Tercyak and P. D. Klein Bile salt alkyl ethers: Evidence for a new class of biliary lipids in human bile. Gastroenterology 67, 795 (1974). CHANGES IN PROFESSIONAL EFFORT No changes, in Professional Personnel or Distribution of Effort,are planned for year 02. Klein, Peter D. PRIVACY ACT MATERIAL REMOVED I. A. The overall objectives of AM 17862 are: 1. To use gas chromatography-mass spectrometry to define the biliary bile acid composition and characterize unusual bile acids in gallstone patients at the Mayo Clinic before and after treatment with chenodeoxy- cholic acid.
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