PPHLN1 Antibody (Internal) Rabbit Polyclonal Antibody Catalog # ALS15883

10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609

Specification

PPHLN1 Antibody (Internal) - Product Information

Application IHC, IF, WB Primary Accession Q8NEY8 Reactivity Human, Mouse Host Rabbit Clonality Polyclonal Calculated MW 53kDa KDa

PPHLN1 Antibody (Internal) - Additional Information Anti-PPHLN1 antibody IHC staining of human Gene ID 51535 brain, cortex.

Other Names Periphilin-1, Gastric cancer antigen Ga50, PPHLN1

Target/Specificity Human PPHLN1 / Periphilin.

Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.

Precautions PPHLN1 Antibody (Internal) is for research use only and not for use in diagnostic or Immunofluorescence of Periphilin in human therapeutic procedures. colon tissue with Periphilin antibody at 5 µg/mL.

PPHLN1 Antibody (Internal) - Protein Information

Name PPHLN1 (HGNC:19369)

Function Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH

Page 1/2 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609

complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May colon tissue lysate with Periphilin antibody at be involved in epithelial differentiation by 1... contributing to epidermal integrity and barrier formation (PubMed:12853457). Involved in epithelial differentiation and Cellular Location contributes to epidermal integrity and barrier Nucleus. Cytoplasm. Chromosome. Note=In formation. undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the PPHLN1 Antibody (Internal) - References nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at Line A.,et al.Br. J. Cancer 86:1824-1830(2002). the cell periphery and at cell-cell junctions Kazerounian S.,et al.J. Biol. Chem. (PubMed:12853457) Localizes to chromatin 278:36707-36717(2003). (PubMed:26022416). Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000). Tissue Location Ota T.,et al.Nat. Genet. 36:40-45(2004). Ubiquitous.. Li W.B.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.

PPHLN1 Antibody (Internal) - Protocols

Provided below are standard protocols that you may find useful for product applications.

• Western Blot • Blocking Peptides • Dot Blot • Immunohistochemistry • Immunofluorescence • Immunoprecipitation • Flow Cytomety • Cell Culture

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