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Annual Research Conference 2016 תקצירים כנס המחקר המרכז הרפואי שערי צדק 18.5.2016 Abstracts Research Conference Shaare Zedek Medical Center SZMC Research Conference 2016 SZMC Research Conference 2016 Conference Schedule 10:15-10:45 State of the Art Guest Lecture Drug treatment for disease prevention - an illustrative case in Alzheimer’s disease Prof. Marta Weinstock-Rosin, Faculty of Medicine, The Hebrew University of 7:30-8:00 Registration and Coffee Jerusalem 8:00-8:15 Welcoming Remarks 10:45-11:45 Second Session Prof. Jonathan Halevy, Director General, Shaare Zedek Medical Center Chairs: Prof. Jacob Rowe and Dr. Floris Levy-Khademi Prof. David Lichtstein, Dean of the Faculty of Medicine, The Hebrew University of Jerusalem Best Abstract: Co-encapsulation of Alendronate and Doxorubicin Prof. Shy Arkin, Vice President for Research and Development, The Hebrew University in Pegylated Liposomes: A novel formulation for chemo-immunotherapy of cancer of Jerusalem Dr. Hilary Shmeeda, Yasmine Amitay, Stephan T. Stern, Yechezkel Barenholz, Alberto Gabizon MK Rabbi Yakov Litzman, Minister of Health Invited Lecture: The next genetic revolution: Gene Editing 8:15-9:30 First Session Prof. Ephrat Levy-Lahad Chairs: Prof. Dan Turner and Dr. Ariella Shitrit Best Abstract: Iron deficiency anemia at admission for labor and delivery is associated Best Abstract: Auditory responses to stimulation at soft tissue sites before and after with an increased risk for Cesarean section, and adverse maternal and neonatal fixation of mobilecomponents of the middle ear outcomes Dr. Ronen Perez, Cahtia Adelman, Jean-Yves Sichel, Haim Sohmer Dr. Lior Drukker, Yael Hants, Rivka Farkash, Rosa Ruchlemer, Arnon Samueloff, Sorina Grisaru-Granovsky Invited Lecture: Parkinson in patients and carriers of Gaucher disease: From Clinical observation in single cases to drug development The Best of Pediatrics Prof. Ari Zimran Prof. Yechiel Schlesinger Best Abstract: Single Cell Testing versus Amniocentesis and NIPT: Ultra-high Best Abstract: Can Dual Energy CT Predict the Need for Surgery in Crohn’s Disease Resolution Preimplantation Screening for Microduplication-Microdeletion Syndromes Dr. Naama Bogot, Ruth Cytter-Quint, Tomer Adar, Roy Biron, Irith Hadas, Dov Wengover, Dr. David Zeevi, Tal Dror, Efrat Burak, Sophie Kirshberg, Elinor Hakam-Spektor, Dina Kort, Eran Goldin Elina Farhi, Merav Ben Shlomo, Sharon Zeligson, Rachel Beeri, Talia Eldar-Geva, Ephrat Levy-Lahad, Gheona Altarescu Best Abstract: Loss-of-function of PCDH12 underlies recessive microcephaly mimicking intrauterine infection The Best of OBGYN Dr. Adi Aran, Nuphar Rosenfeld, Ranit Jaron, Paul Renbaum, Shachar Zuckerman, Hila Fridman, Sharon Prof. Uzi Beller Zeligson, Reeval Segel, Yoav Kohn, Lara Kamal, Moien Kannan, Yoram Segev, Eyal Mazaki, Ron Rabinowitz, Ori Shen, Ming K. Lee, Tom Walsh, Mary-Claire King, Suleyman Gulsuner, Ephrat Levy-Lahad Invited Lecture: Meet RedCap - a data managing software for research, available for all at SZMC The Best of Surgery Ms. Gili Focht Prof. Petachia Reissman The Best of Internal Medicine 11:45-12:00 Awards for Outstanding Research Projects Prof. Amos Yinnon Advanced Researchers Category Medical Students, Interns and Residents Category Best Abstract: Shift Handover in the Intensive Care Unit Ms. Chaya Broyer 12:00 Closing Remarks Prof. Dan Turner Invited Lecture: Cytomegalovirus infection in pregnancy: studies of maternal immune system in relation to fetal infection 12:00-13:00 Lunch & Poster Viewing Prof. Yechiel Schlesinger Round Table Discussions 4th floor Patio 9:30-10:15 Poster Viewing and Coffee Break In collaboration with The Hebrew University of Jerusalem’s IMRIC Research Hubs 2 3 SZMC Research Conference 2016 SZMC Research Conference 2016 שלום רב, שלום רב, רופאים וחוקרים יקרים, עיסוק במחקר בסיסי וקליני לצד שרות קליני והוראה הם נשמת אפו של כל בית חולים ובוודאי של בית חולים אוניברסיטאי בעל אין חולק על העוצמה הקלינית של המרכז הרפואי שערי צדק. גדלנו, התפתחנו והוספנו שירותים חדשים. הציבור מצביע סינוף אוניברסיטאי מלא לפקולטה לרפואה. ברגליים ומספר הפונים לקבל אצלנו טיפול הולך ועולה. בשנים האחרונות הוקמה רשות מחקר, נחתם הסכם עם חברת אבל זה לא כל הסיפור. בד בבד למגמה זו, כמעט בהיחבא, יישום של האוניברסיטה העברית )"יישום"(, הושגו מענקי מחקר אנו עדים למהפכה אמיתית בארגון המחקר והפיתוח בשערי רבים, התרחב שיתוף הפעולה עם תעשיית התרופות לניהול צדק. מאז 2011 הוקמה הרשות למחקר ופיתוח ובעקבותיה גם מחקרים ביוזמת החוקרים או החברות ונבחנו רעיונות רבים של חברת מדעית שע”צ למסחור ידע, נחתם הסכם שיתוף פעולה חברי סגל בית החולים לקראת יישום ורישום פטנט. אסטרטגי עם חברת יישום של האוניברסיטה העברית, הוקמו כתוצאה מפעילות ברוכה זו, קבלה הפעילות המחקרית במוסדנו תנופה רבה, מתפרסמים מדי קרנות פנימיות לתמיכה משמעותית במחקר עצמאי, הוקצו משאבים לפיתוח פטנטים וקידום שנה למעלה מ300- מחקרים בספרות המקצועית, חלקם בעיתונות מן השורה הראשונה. רעיונות מסחריים, הוסדרו נהלים, ושונו סדרי עדיפויות. דרך הרשות למו”פ וחברת מדעית אנו חותמים על למעלה מ- 170חוזי מחקר וייעוץ כל שנה ומנהלים גרנטים אקדמיים בהיקף של מליוני לעונג לי לקדם בברכה את כנס המחקר הראשון בשערי צדק במסגרתו יוצגו לצבור עובדי בית שקלים. במקביל, מנוהלים במדעית מספר לא מבוטל של פרוייקטים למסחור, פטנטים, הסכמי החולים ולמבקרים מבחוץ מפירות התנובה המחקרית שלנו. שירות וייעוץ. ההיענות לפניית רשות המחקר הייתה גבוהה ומרגשת והניבה כ180- תקצירי עבודות מחקר כנס מחקר זה, הראשון בתולדות שערי צדק, מביא באחת לחזית את העשייה המחקרית הענפה המוצגות בפניכם במסגרת יום מחקר זה. במוסד. 180התקצירים הכלולים בספר זה משקפים עוצמה מחקרית מרשימה בהיקפה ואיכותה. מרשים לא פחות הייצוג המכובד לכל המחלקות והיחידות הרפואיות, כולל הסיעוד והמקצועות ברכותיי למארגנים, בייחוד לדר’ רננה אופן ונתניה בר כוכבא, ואיחוליי ליום מחקר פורה במהלכו הפרא-רפואיים. רופאי וחוקרי שערי צדק מפרסמים למעלה מ 300 מאמרים כל שנה, ומספר ניווכח כולנו בתרומתו המשמעותית של שערי צדק למחקר הרפואי, ובכך כמובן לרווחת החולים הפרסומים עולה בשנים האחרונות בקצב של כ 5-10% לשנה. בארץ ובעולם. אל לנו לנוח על זרי הדפנה כי מלאכה רבה עוד לפנינו. פיתוח המדע הבסיסי כולל בניית מעבדות פרופ’ יונתן הלוי חדשות, עידוד רופאים להגיש גרנטים אקדמיים חיצוניים, שילוב חוקרי ורופאי שערי צדק ברשתות מנכ”ל המרכז הרפואי מחקר ארציות ובינלאומיות, קידום פטנטים ורעיונות יישומיים והגדלת נפח המחקר עם חברות התרופות. כנס זה הוא חגיגת מחקר בראש ובראשונה לחוקרים עצמם שמשקיעים מעבר לדרישות הקליניות של התפקיד מתוך אמונה שמחקר חשוב לרפואה ולמטופלים. תודה מיוחדת לנתניה בר כוכבא, ד”ר רננה אופן, טלי כץ וקטרינה אלירז על מסירות רבה ועבודה יומיומית מקצועית ליצירת תנאים מיטביים לעשייה מחקרית ויזמית. תודה גדולה גם לוועדת הלסינקי המוסדית בראשות ד”ר ואן דייק על עבודה אינטנסיבית וברמה הגבוהה ביותר לשמירת גבולות האתיקה של המחקר. ביום חג זה אני מברך את כולנו להמשך עשייה מחקרית פוריה ומועילה לטובת החולים והרפואה. פרופ’ דן טרנר עוזר מנכ”ל למו”פ 4 5 SZMC Research Conference 2016 SZMC Research Conference 2016 Table of Contents Division of Imaging ....................... 8-11 General Surgery Radiology Ophthalmology Plastic Surgery Division of Internal Medicine ..... 12-84 Recovery Cardiology Wilf Children's Hospital .......... 145-186 Digestive Diseases Institute General Pediatrics Gaucher NICU General Internal Medicine Pediatric Emergency Medicine Genetics Pediatric Endocrinology Geriatrics Pediatric Gastroenterology Hematology Pediatric Nephrology Infectious Disease Unit Pediatric Neurology Intensive Care Pediatric Orthopedics Nephrology Pediatric Rheumatology Oncology Pulmonary Institute Nursing and Complementary Care .............. 187-199 Division of Obstetrics, Emergency Department Gynecology and IVF ................. 85-109 General Nursing Obstetrics and Gynecology Intensive Care Noga Division of Surgery Occupational Therapy and Anesthesia ........................110-144 Pathology Breast Surgery Unit Psychiatry Center for Trauma Research ENT 6 7 SZMC Research Conference 2016 SZMC Research Conference 2016 Imaging Imaging Gastric Embolization Trial for Morbid Obesity (GETMO Trial) Can Dual Energy CT Predict the Need for Surgery in Crohn's Disease? Adam Farkas, MD. Senior Physician, Vascular and Interventional Radiology, Shaare Zedek Medical Center. Bogot NR, Cytter-Quint R, Adar T, Biron R, Hadas I, Wengrower D, Goldin E Ram Shapira, MD. Senior Physician, Surgery, Shaare Zedek Medical Center. Anthony Verstandig, MD. Gabi Munter, MD. Menachem Schechter, MD. Senior Physicians in Vascular PURPOSE: Dual energy CT (DECT) is sensitive for detection and quantification of iodine in tissue. and Interventioanl Radiology (AV), Endocrinology (GM), and Gastroenterology (MS) We aimed to evaluate the correlation between iodine uptake in the inflamed bowel wall in Crohn's disease (CD) and the need for surgery and create an inflammtory index. Background/Aims: To evaluate the safety and efficacy of gastric artery embolization as a minimally- invasive option to induce weight loss in the morbidly obese. METHOD AND MATERIALS: IRB approved prospective double-blind study. 36 patients (mean age 38.6 years, 20 males) with Crohn's disease (CD) underwent a DECT (Somaton Flash) for acute Morbid obesity has reached global epidemic proportions and continues to rise in prevalence. It abdominal symptoms. Study protocol: abdominal-pelvic CT using DE mode (100 and 140kV), IV is associated with a myriad of health problems, including gallstones, type 2 diabetes, high blood contrast and negative oral contrast contrast. The DECT was interpreted by a radiologist blinded to pressure, high cholesterol and triglycerides, coronary artery disease (CAD), stroke, some cancers, the clinical outcome. The referring physicians were blinded to DECT interpretation. Studies were and sleep apnea, among other conditions. Diet and exercise are ineffective
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