Some Traditional adverse effect and its Modality as Resource * Dr. Yugandhara Rajgure/ Gulhane and **Dr. Minal Keche Department of Botany *G. S. Tompe Arts, Commerce and Science College, Chandur Bazar, Amravati, Maharashtra **Rajashree Shahu Science College Chandur Railway, Dist. Amravati. [email protected] Abstract Since long time large proportion of the people both in rural and urban centers rely on traditional plants for their every day health needs. In developing it is common practice of using herbal medicines. Some herbal medicine can have dangerous side effects; and can leads to major complications due to overdose taken. parts of Terminalia bellerica ,Mukia maderespatana , minuta and many more can resulted in complications due to excess consumption. The effect of this is an inadequate knowledge of their mode of action, potential adverse reactions. Studies and awareness needed to avoid such complications. Key words: Traditional plants, herbal medicine, adverse reaction, public health.

I INTRODUCTION Now a days with the pandemic going on with Covid-19 obviously public interest increases in natural therapies both in developing and developed countries. Herbal remedies being available in drug stores, local markets, in food stores and also in supermarkets. It is estimated that up to four billion people (representing 80% of the world’s population) living in the developing world rely on herbal medicinal products as a primary source of healthcare and traditional medical practice which involves the use of herbs is viewed as an integral part of the culture in those communities (2).Medicinal plants are resources of new drugs. It is estimated there are more than 250, 000 flower plant . Studying medicinal plants helps to understand plant toxicity and protect human and animals from natural poisons. Cultivation and preservation of medicinal plants protect biological diversity; pharmaceutical industry extracts the active ingredient to make plant-derived drugs. In routine life people are practicing for very few exotic plant crops, advocacy of wild plants can provide a solution for both nutrition and health benefits. Tribal groups and folk people all over the planet have their own knowledge, culture and life style. Traditional herbal treatment is preferred with the belief that it will promote healthier living. Herbal medicines are, therefore, often viewed as a balanced and moderate approach to healing individuals who use them as home remedies and over-the-counter drugs spend

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huge amount of money on herbal products. This explains in part the reason sales of herbal medicines are booming and represents a substantial proportion of the global drug market ( 2,10)

II OBSERVATION Quest for documentation of traditional knowledge, has been concentrated especially around traditional health practices. Plant-based traditional knowledge has become a recognized tool in search for new sources of drugs. Many plants used in or used as food have demonstrated some toxicity effects. However , some of the toxic plants are useful to man as medicines such well known medicinal plants have demonstrated toxicity in laboratory studies and fields observations. For example, The seeds of Terminalia bellerica Seed eaten raw by the tribals. It is observed that seed produces drowsiness if eaten in excess. Fruits of Terminalia shows Anti-arthritic, antibacterial and antispasmodic properties (3,4). Ripe fruits of Mukia maderespatana are eaten raw. It causes if eaten in excess. Fruit are medicinally useful on abdominal disorders, and vomiting. Seeds of Mukia are Sudorific it treats vertigo, biliousness and toothache (3,7). Marsilea minuta young are sweet in taste and cooked as vegetable. Consumption of leaves leads to abortion in women. Leaves are useful to treat dyspepsia many skin diseases and behavioral disorders. (8) Lantana camera used in the management of malaria and other diseases has been reported to be hepatotoxic in several animal species which could be of concern regarding its chronic use in man. Similarly, Momardica charantia, a known antidiabetic and antimalarial plant but also used in as an abortifacient. They had been used in traditional medicine. Also, it is noted that the route of administration and dose, of any chemical, are important regarding safety due to chemical or pharmacological interactions; this is undergirded by the need for a regulatory regime for quality (5).

III DISCUSSION The development as well as implementation of the regulation of traditional or herbal medicines in different parts of the world is often confronted with several challenges. Challenges often encountered and common to many countries are those related to regulatory status, assessment of safety and efficacy, quality control, safety monitoring and inadequate or poor knowledge about traditional, complementary/alternative, and herbal medicines within national drug regulatory authorities (11). So also, because of the influence of religion and greater level of spiritual consciousness, many individuals tend to be increasingly disposed to accepting therapeutic value of a treatment based on faith or intuition rather than scientific reasoning (1, 12) Herbal medicines, therefore, become particularly alluring when the body’s natural capacity for self-repair, given appropriate conditions, is 266 | P a g e

emphasized (6). With the enormous global consumption of herbal products and medicines, it is high time they were included in pharma covigilance systems. In terms of population exposure alone, it is essential to identify the risks associated with the use of herbal medicines, and in this regard, the safety of these products has become an issue of great public health importance (9,11). There is no doubt that the increasing cases of poisoning associated with the use herbal medicines in many parts of the world in recent times, is necessitating the need to ensure thorough toxicity assessment alongside active pharma covigilance on these products in order to promote their safe use and protect public health .(13)

IV CONCLUSION Traditional knowledge , belief and cultural impact always drive people to consume herbal medicines. This reliability on the native healers leads to use this medicine. The limited scientific knowledge among the general population has led to the general assumption that herbal medicines being natural are therefore safe. However, real fact is different, some toxicological studies proves that plant parts shows toxic potentiality thus affecting their safe use.

Standardization of the herbal medicines products must be taken in consideration on priority basis by the producers. Serious adverse effects of therapies and investigation the toxic effects of organic solvent plant extracts is necessary for the society. Information on the traditional formulation and use of the herbal medicines should be satisfactory to avoid possible toxicity from the medicinal plants.

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