PRKCE polyclonal antibody be activated by and the second messenger diacylglycerol. PKC family members phosphorylate a Catalog Number: PAB4537 wide variety of targets and are known to be involved in diverse cellular signaling pathways. PKC Regulatory Status: For research use only (RUO) family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each Product Description: Rabbit polyclonal antibody raised member of the PKC family has a specific expression against synthetic peptide of PRKCE. profile and is believed to play a distinct role in cells. The protein encoded by this is one of the PKC family Immunogen: A synthetic peptide (conjugated with KLH) members. This has been shown to be involved in corresponding to amino acids 213-243 at N-terminus of many different cellular functions, such as human PRKCE. channel activation, , from , , as well as insulin Host: Rabbit exocytosis. Knockout studies in mice suggest that this Reactivity: Human kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and Applications: ELISA, IHC-P, WB-Ti, WB-Tr may also play a role in controlling anxiety-like behavior. (See our web site product page for detailed applications [provided by RefSeq] information) References: Protocols: See our web site at 1. Activated PKC{delta} and PKC{epsilon} inhibit http://www.abnova.com/support/protocols.asp or product epithelial chloride secretion response to cAMP via page for detailed protocols inducing internalization of the Na+-K+-2Cl- cotransporter NKCC1. Tang J, Bouyer P, Mykoniatis A, Buschmann M, Form: Liquid Matlin KS, Matthews JB. J Biol Chem. 2010 Aug 23. [Epub ahead of print] Purification: Protein G purification 2. Induction of neurites by the regulatory domains of PKCdelta and epsilon is counteracted by PKC catalytic Recommend Usage: ELISA (1:1000) activity and by the RhoA pathway. Ling M, Troller U, Western Blot (1:100-500) Zeidman R, Lundberg C, Larsson C. Exp Cell Res. 2004 Immunohistochemistry (1:50-100) Jan 1;292(1):135-50. The optimal working dilution should be determined by 3. Preservation of base-line hemodynamic function and the end user. loss of inducible cardioprotection in adult mice lacking C epsilon. Gray MO, Zhou HZ, Storage Buffer: In PBS (0.09% sodium azide) Schafhalter-Zoppoth I, Zhu P, Mochly-Rosen D, Messing Storage Instruction: Store at 4°C. For long term RO. J Biol Chem. 2004 Jan 30;279(5):3596-604. Epub storage store at -20°C. 2003 Nov 4. Aliquot to avoid repeated freezing and thawing.

Entrez GeneID: 5581

Gene Symbol: PRKCE

Gene Alias: MGC125656, MGC125657, PKCE, nPKC-epsilon

Gene Summary: (PKC) is a family of - and -specific protein that can

Page 1/1

Powered by TCPDF (www.tcpdf.org)