volume 13 ucsf department of neurological surgery news

The Next Generation of Neurosurgeons Residents in the Department of Neurological Surgery Educating future academic by the Program Director Michael neurosurgeons is central to the McDermott MD and Associate Jonathan Breshears MD Nathan Rowland MD, PhD mission of the Department of Program Director Paul Larson MD, Tene Cage MD Martin Rutkowski MD Neurological Surgery at UCSF. The together with Department Chair Andrew Chan MD Caleb Rutledge MD University was one of the earliest Mitchel Berger MD and Residency Jason Davies MD, PhD Michael Safaee MD training grounds in the United Coordinator Kimberly Bissell. Dario Englot MD, PhD Rajiv Saigal MD, PhD States for the field of neurosurgery. Seunggu Han MD Derek Southwell MD, PhD “We receive extremely competitive Beginning as early as 1913, Howard Darryl Lau MD Doris Wang MD, PhD applications,” says Dr. McDermott. Naffziger MD – then an assistant in Stephen Magill MD, PhD Ethan Winkler MD, PhD “Our goal is to train the next genera- surgery at the School of Medicine Joseph Osorio MD, PhD Corinna Zygourakis MD tion of academic neurosurgeons, and an early pioneer of neurosurgery John Rolston MD, PhD who will continue to advance the – began training surgical residents field. The majority of our residents by preceptorship to gain exposure continue on to very prestigious to operations involving the brain and faculty appointments in academic As the field of neurosurgery becomes spinal cord, such as decompressive neurosurgery departments and many increasingly subspecialized, residency craniotomy for brain tumors. complete additional fellowship train- training at UCSF has shifted to In 1934, the American Medical ing prior to becoming faculty.” provide immersion into these various Association Council on Medical For Ethan Winkler MD, PhD, who subspecialties. Residents rotate Education and gave began his first year of the residency through services in neurocritical care, approval to UCSF for a three-year program in June, the biggest draw spinal disorders, movement disorders, training program in neurosurgery to UCSF was the chance to learn epilepsy, pediatric neurosurgery, consisting of one clinical year at from the best. “After interviewing radiosurgery, neuroendovascular each of three hospitals: Franklin at neurosurgery programs across surgery, cerebrovascular surgery, ; the Veterans the country, it became clear to peripheral nerve surgery, and brain Administration (SFVA) Hospital; and me that training in an environment tumor surgery. San Francisco General Hospital surrounded by some of the “The best part and main advantage (SFGH). By 1969, the program was most prominent leaders in both of being a resident at UCSF is increased to five years and included neuroscience and neurosurgery was exposure to so many true experts one full year of research. The a very unique opportunity,” said in each and every subfield of Department attracted 50 applicants Dr. Winkler. “I was in search of a neurosurgery,” says 2014 graduate in 1968 and 100 applicants in 1994. residency program that placed great Aaron Clark MD. “The breadth of In 2014, over 200 candidates emphasis on using scientific and UCSF neurosurgery is unparalleled.” applied to fill three positions in clinical excellence to enhance each Currently, neurosurgery residents the Department’s seven-year other, not retract from one another.” rotate through services at Moffitt/ residency program. It is overseen Long Hospitals at the UCSF Medical Center; SFVA Medical Center; SFGH; and the UCSF Benioff Children’s Hospitals in San Francisco and Oakland. In 2017, the program will expand to include a rotation in neuroendovascular surgery at in Sacramento. In 2015, all pediatric rotations will be centralized at the newly constructed Benioff Children’s

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University of Department of Neurological Surgery San Francisco , San Francisco 400 Parnassus Avenue, 8th Floor Box 0350 San Francisco, CA 94143-0350 Phone: (415) 353-7500 Neurological Surgery Fax: (415) 353-2889 http://neurosurgery.ucsf.edu looking to the future

A major change in neurosurgery to no impact on patient care. The residency training at UCSF occurred neurosurgery service, due to the in 2013 when our Department high volume of patients and frequent was chosen as one of seven usage of the ICU, has high lab neurosurgery programs in the usage. However, only few labs seem country to participate in the pilot to truly the change course of care. program of the new guidelines for Reducing unnecessary lab testing residency training by the Society for has, as a result, reduced waste and Neurological Surgery — the Next cost at the UCSF Medical Center. Accreditation System (NAS) and In addition to in-depth exposure to a implementation of milestones. wide variety of clinical programs (see Our program reviews will be Page 1), the residents attend weekly measured with new outcomes-based neuroscience lectures by a rotating milestones for resident performance faculty member; multidisciplinary within six domains of clinical case conferences; grand rounds; competence. The milestones are and an active schedule of seminars, competency-based developmental journal clubs, and lecture programs. Mitchel S. Berger MD outcome expectations that can During our annual Resident Research Berthold and Belle N. Guggenhime be demonstrated progressively Day, each resident presents a Professor and Chair by residents and fellows from the scientific manuscript published that beginning of their education through year and the faculty gives an award Director, graduation to the unsupervised for the best basic science and best Brain Tumor Research Center practice of their specialty. Program clinical science manuscript. The Department of directors Michael McDermott MD day is designed to recognize the Neurological Surgery, UCSF and Paul Larson MD steered an extraordinary research achievements overhaul of the curriculum to meet of the residents and expose them to this new structure so that our other research taking place at UCSF. residents will be prepared for every All of these teaching activities are stage of assessment. 2 essential to exposing residents to the Another shift in the program has breadth of neurosurgical specialties, been to institute a formal quality but the most important and improvement curriculum. We were satisfying component of education is the first Neurosurgery Department one-on-one mentorship. Our faculty in the nation to make Patient members are extremely committed Safety and Quality Improvement to mentoring our residents at a formal part of our residency every stage of their training. It program, and we were recognized takes place in the operating room for that distinction at the 2013 and at clinic visits, in laboratories annual meeting of the Society for and classrooms, and at meetings Neurological Surgery. The residents and retreats designed to foster participate in case review and collaboration. At UCSF, we aim to ongoing departmental quality create an environment that not only improvement projects, including provides superb technical training, an initiative that limited utilization but also one that supports research of laboratory tests that have little productivity, professionalism, and personal growth. cont. from page 1 Hospital at the Mission Bay campus. me through career decisions and “This is a state-of-the-art hospital develop my research goals,” says that will provide a unique training 2014 graduate Michael Ivan MD. environment for residents,” says Dr. “They have allowed me to participate Larson. “By housing all the pediatric in their research and then given Residents attend a 3-D lecture on neuroanatomy taught by Arnau Benet MD. From left: Rajiv Saigal MD, specialties in a dedicated hospital, me the resources to expand on PhD; Doris Wang MD, PhD; Dario Englot MD, PhD; our residents will be exposed to my own. I cannot imagine a better Seunggu Han MD true multidisciplinary pediatric care, program to prepare for beginning a which cannot be found at many other career in academic neurosurgery.” In training programs.” 2012, Dr. Ivan received a fellowship from the Neurosurgery Research The fifth year of the Neurological While preparation for future and Education Foundation of the Surgery residency program is academic careers is the ultimate American Association of Neurological devoted to a research project in goal of the program, the residents Surgeons to support his research clinical or basic neuroscience, and leave with more than surgical and into the pathogenesis of glioma. allows residents to design a program laboratory skills: they are members that suits their interests, to function “Ultimately, I think the residents of a dedicated and accomplished as independent investigators, and to leave here with a very well-rounded team that works to improve the take advantage of the rich research experience and are prepared to lives of patients. “The staff and opportunities and technologies thrive in academic neurosurgery faculty are a true team and give available at UCSF. They also gain careers,” says Dr. Larson. “By the residents tremendous support experience with presenting data at becoming immersed in so many throughout their time here,” says Dr. national meetings and publishing specialties, they are really able to Ivan. “I am extremely thankful for this scientific manuscripts. choose individualized career paths opportunity to be a part of the UCSF and compete for top academic family and have made many lifelong “Both clinically and academically fellowships and attending positions.” friends through my journey here.” I have had access to outstanding mentors that have helped guide

3 UCSF Neurosurgery Resident Awards in 2013-2014 Jonathan Breshears MD Stephen Magill MD, PhD Tene Cage MD won the Top Gun ventriculostomy Young Investigator Award, San John H. Moe Basic Science Award, competition for her accuracy and speed at the Annual Meeting of the American Association of Francisco Neurological Society Scoliosis Research Society Neurological Surgeons. Tene Cage MD John Rolston MD, PhD First place for Ventriculostomy National Research Service Award, at the Top Gun Competition at National Institutes of Health the Annual Meeting of the Nathan Rowland MD, PhD American Association for National Research Service Award, Neurological Surgeons National Institutes of Health Dario Englot MD, PhD Caleb Rutledge MD Best Resident Research Krevins Award for Clinical Presentation, Annual Meeting Excellence, San Francisco of the California Association of General Hospital Neurological Surgeons Rajiv Saigal MD, PhD Harold Rosegay Resident Teaching Best Basic Science Presentation Award, UCSF Department of Award, 2014 Resident Research Neurological Surgery Day, UCSF Department of Michael Ivan MD Neurological Surgery UCSF School of Medicine Class of Doris Wang MD, PhD 2014 Teaching Award for Cherished Best Clinical Science Presentation Housestaff Award, 2014 Resident Research Elected to the Young Neuro- Day, UCSF Department of surgeon’s Committee Board, Neurological Surgery American Association of Corinna Zygourakis MD Neurological Surgeons UCSF Caring Wisely Grant for Naffziger Outstanding Resident Reducing Operating Room Costs Award, UCSF Department of though Price Transparency Neurological Surgery resident gazette

Jason S. Cheng MD completed his Grupe Award for Excellence in undergraduate studies at Stanford Alzheimer’s Research, and the UCSF University, majoring in Biological Dean’s Research Prize. Sciences and minoring in Computer Dr. Cheng began his neurosurgical Science. He then entered the UCSF training at UCSF in 2009, after School of Medicine in 2002 to begin completing an internship in general his medical training. surgery at UCSF. During that time he In 2005, Dr. Cheng was awarded a developed a broad interest in several two-year Howard Hughes Medical areas of neurosurgery including Institute Research Fellowship to pituitary surgery, minimally invasive conduct research in the laboratory spine surgery, and traumatic brain selected publications of Lennart Mucke MD, studying the injury. He continued his work with Cheng JS, Ivan ME, Stapleton CJ, Quinones- role of collagen VI protein in a mouse Dr. Mucke during his research year, Hinojosa A, Gupta N, Auguste KI.Intraoperative changes in transcranial motor evoked potentials model of Alzheimer’s disease. This studying the role of Tau protein in and somatosensory evoked potentials predicting work led to a publication in Nature a mouse model of traumatic brain outcome in children with intramedullary spinal cord tumors. J Neurosurg Pediatr 2014;13(6):591-9. Neuroscience, for which Dr. Cheng injury. After completing his residency, Cheng JS, Lim DA, Chang EF, Barbaro NM. A was co-first author, the Kathryn Dr. Cheng plans to establish his review of percutaneous treatments for trigeminal clinical practice in California. neuralgia. Neurosurgery 2014;10 Suppl 1:25-33. Cheng JS, Park P, Le H, Reisner L, Chou D, Mummaneni PV. Short-term and long-term outcomes of minimally invasive and open transforaminal lumbar interbody fusions: is there a difference? Neurosurg Focus 2013;35(2):E6. Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L. Collagen VI protects neurons against Abeta toxicity. Nat Neurosci 2009;12(2):119-21.

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Aaron J. Clark MD, PhD is native During the course of residency San Franciscan and left for the training, he developed a new interest University of California, San Diego to in spinal neurosurgery. In this field, complete his undergraduate studies, he has published research on spinal majoring in microbiology. He then oncology, spine biomechanics, entered the MD/PhD program at spinal deformity, and intraoperative the Medical College of Virginia in neurophysiological monitoring during Richmond, Virginia. spine surgery. His graduate research focused After completing residency in June on elucidating the expression and 2014, Dr. Clark began additional selected publications function of the Wilms’ tumor 1 (WT1) fellowship training in minimally gene in human malignant glioma. Clark AJ, Tang JA, Leasure JM, Ivan ME, invasive spine surgery at the Kondrashov D, Buckley JM, Deviren V, Ames CP. This interest in brain tumors led him Semmes-Murphey Neurologic Gait-simulating fatigue loading analysis and sagittal to pursue neurosurgery residency and Spine Institute in Memphis, alignment failure of spinal pelvic reconstruction after total sacrectomy: comparison of 3 techniques. training at UCSF, which he began Tennessee under the mentorship J Neurosurg Spine 2014;20(4):364-70. in 2008. of Kevin Foley MD. Clark AJ, Ziewacz JE, Safaee M, Lyon R, Chou D, Weinstein PR, Ames CP, Clark III JP, Mummaneni At UCSF, Dr. Clark extended his PV. Intraoperative neuromonitoring with MEPs and research into brain tumor clinical prediction of postoperative neurological deficits in patients undergoing surgery for cervical and outcomes research and brain tumor cervicothoracic myelopathy. Neurosurg Focus immmunotherapy models. Dr. Clark 2013;35(1):E7. was awarded an NIH National Clark AJ, Butowski NA, Chang SM, Prados MD, Research Service Award to support Clarke JL, McDermott MW, Parsa AT, Berger MS, Aghi MK. Neurosurgical management and prognosis his laboratory research. of patients with glioblastoma that progress during bevacizumab treatment. Neurosurgery 2012;70(2):361-70.

Clark AJ, Lu DC, Richardson RM, Tihan T, Parsa, AT, Chou D, Barbaro NM, Kunwar S, Weinstein PR, Lawton, MT, Berger MS, McDermott MW. Temporary arterial occlusion in the operative management of spinal hemangioblastomas. World Neurosurg 2010;74(1):200-5. Michael E. Ivan MD, MBS completed PhD was awarded the Neurosurgical his undergraduate studies at Cornell Research and Education Foundation University where he received a (NREF) grant in 2012. degree in Chemical and Biological Dr. Ivan has also taken a strong Engineering. Dr. Ivan then went on interest in teaching medical students to work at Merck Pharmaceuticals and has taught multiple medical for four years as an engineer in the school courses. He was recently Vaccine Technology and Engineering awarded the 2014 Teaching Award for Division, and received his Masters Cherished Housestaff (TEACH) from in Biomedical Sciences at UMDNJ. the UCSF medical school Class of In 2004, he entered medical school 2014. He is an active member of the at UMDNJ-New Jersey Medical Young Neurosurgeon’s Committee. selected publications School, where he worked closely with In his spare time, Dr. Ivan enjoys Ivan ME, Yarlagadda J, Saxena A, Martin AJ, Michael Schulder MD on the use of Starr P, Sootsman K, Larson PS. Brain shift downhill skiing and has defended intraoperative MRI for pituitary tumors analysis during burr hole-based procedures the title of the men’s ski champion using interventional MRI [published online and Paul Larson MD on the use of ahead of print May 2, 2014]. J Neurosurg. doi: at the “Neurosurgery in the Rockies” intraoperative MRI for investigating 10.3171/2014.3.JNS121312 conference for the last four years. brain shift during minimally invasive Ivan ME, Jahangiri A, El-Sayed IH, Aghi MK. After finishing residency in June Minimally invasive approaches to the anterior skull burr hole procedures. base. Neurosurg Clin N Am 2013; 24(1):19-37. 2014, Dr. Ivan began a clinical Dr. Ivan began residency in the Ivan ME, Cheng, JS, Sughrue ME, Kane AJ, Aranda and research fellowship in Neuro- D, McDermott M, Barani IJ, Parsa AT. Association Department of Neurological Surgery Oncology at the University of Miami. of morbidity with extent of resection and cavernous at UCSF in 2008, focusing on the sinus invasion in sphenoid wing meningiomas. J He plans on continuing his research treatment and management of Neuro Surg B Skull Base 2012;73(1):76-83. on targeted therapies toward the both vascular and tumor skull base Ivan ME, Sughrue ME, Clark AJ, Kane AJ, Aranda prevention of brain tumor invasion. D, Barani IJ, Parsa AT. A meta-analysis of tumor lesions. Dr. Ivan’s basic science He then anticipates a career in control rates and treatment-related morbidity for research has been focused on the patients with glomus jugulare tumors. J Neurosurg academic neurosurgery where he 2011;114(5):1299-305. invasive qualities of brain tumors. His hopes to combine his interest in work on the role of EMR proteins in neuro-oncology and cerebrovascular glioma pathogenesis and invasion in disease with minimally invasive and 5 the laboratory of Andrew Parsa MD, open skull base approaches. focus on faculty

implantation, including frameless basal ganglia in auditory perception, techniques and the use of high-field, particularly phantom auditory real-time intraoperative magnetic disorders such as tinnitus. He is also resonance imaging (MRI). He has involved in studies using high-field significant surgical experience in MR brain imaging for clinical and the use of intraoperative MRI for a basic science research. number of neurosurgical applications. During his residency, Dr. Larson was extensively involved in the selected publications development of the Norton Hospital Larson PS. Deep brain stimulation for movement disorders [published online ahead of print May 15, Paul Larson MD, associate professor intraoperative MRI program, and 2014]. Neurotherapeutics. 10.1007/s13311- and vice chair of neurological spent a year in the Speed School of 014-0274-1. surgery, has clinical interests Engineering’s Computer Vision and Vega RA, Holloway KL, Larson PS. Image- Image Processing Lab studying the guided deep brain stimulation. Neurosurg Clin in stereotactic and functional N Am 2014;25(1):159-72. neurosurgery, particularly with basic science of CT and MR image Ostrem JL, Galifianakis NB, Markun LC, Grace JK, regard to movement, psychiatric, analysis and 3D modeling. Martin AJ, Starr PA, Larson PS. Clinical outcomes and auditory disorders. He has of PD patients having bilateral STN DBS using high- Dr. Larson’s research interests field interventional MR-imaging for lead placement. been involved in the development include MRI-guided stereotaxis, Clin Neurol Neurosurg 2013;115(6):708-12. and evolution of novel surgical gene therapy, and the role of the Larson PS, Cheung SW. A stroke of silence: methods for deep brain stimulator tinnitus suppression following placement of a deep brain stimulation electrode with infarction in area LC. J Neurosurg 2013;118(1):192-4. neurosurgery news & notes

detailed the optimal protocol for performing awake craniotomies with the lowest failure rate. Adam Ferguson PhD was awarded a Wings for Life Foundation Grant for the project “Harnessing SCI Big Data to Accelerate Translation.” The goal of this project is to drive innovation Red, orange and yellow regions represent typical areas of white matter injury seen on diffusion tensor imaging (DTI). in biomedical informatics tools for These DTI patterns, combined with topological data analysis, will help investigators Adam Ferguson and Esther Yuh animal-to-human translation. Dr. further define subgroups within the traditional ‘mild’ traumatic injury population. Ferguson was also awarded a GE NFL Head Health Challenge Grant Manish Aghi MD, PhD was given the Dr. Baraban was also the recipient for work that will use topological Journal of Neuro-Oncology Award of the 2013/14 Sackler Sabbatical analysis of diffusion tensor imaging at the 2014 Annual Meeting of the Exchange Program from the to diagnose and predict outcome American Association of Neurological Raymond and Beverly Sackler following mild traumatic brain injury. Surgeons. He was also given the Center for Biomedical, Physical Society for Neuro-Oncology Young and Engineering Sciences. The Praveen Mummaneni MD has been Investigator Award at the Society’s prestigious program provides voted Chair Elect of the AANS/CNS annual meeting in November 2013. support for faculty from UCSF and Joint Section on Disorders of the UC Berkeley to take a sabbatical at Spine and Peripheral Nerves. The Scott Baraban PhD will serve as co- the other institution for one year to Joint Section also presented Dr. chair of the 2014 Gordon Research foster collaboration with colleagues Mummaneni with the Haid Deformity Conference on Mechanisms of in other fields. Award, together with Dr. Kai-ming Fu Epilepsy and Neuronal Synchroni- of Weill Cornell Medical College. zation. The conference will take place Mitchel Berger MD presented the August 17-22 in West Dover, VT and largest awake craniotomy series ever Arie Perry MD has been appointed will provide a forum for presentations reported at a plenary session of the as a Senior Advisor for the next World of unpublished findings related American Association of Neurological Health Organization brain tumor classification scheme, scheduled for 6 to basic mechanisms of epilepsy, Surgeons Annual Scientific Meeting current translational studies and on April 6, 2014. The presentation publication in early 2016. synchronization of neuronal activity in cerebral networks.

focus on faculty

selected publications Michael McDermott MD has Wang DD, Lau D, Rolston JD, Englot DJ, Sneed PK, clinical specialty interests in McDermott MW. Pain experience using conventional meningiomas, skull base tumors, versus angled anterior posts during stereotactic head frame placement for radiosurgery. J Clin gliomas, radiosurgery, and Neurosci. 2014 May 6. pii: S0967-5868(14)00093-9. hydrocephalus. He holds several Sughrue ME, Rutkowski MJ, Chen CJ, Shangari positions in the Department as G, Kane AJ, Parsa AT, Berger MS, McDermott Professor and Vice-Chairman, the MW. Modern surgical outcomes following surgery for sphenoid wing meningiomas. J Neurosurg Robert and Ruth Halperin Chair in 2013;119(1):86-93. Meningioma Research, Neurosurgery Caballero JA, Sneed PK, Lamborn KR, Ma L, Residency Program Director, and Denduluri S, Nakamura JL, Barani IJ, McDermott MW. Prognostic factors for survival in patients Co-Director of the UCSF Gamma treated with stereotactic radiosurgery for Knife® Radiosurgery Program. He recurrent brain metastases after prior whole also practices in the Department’s brain radiotherapy. Int J Radiat Oncol Biol Phys research is focused on clinical 2012;83(1):303-9. Skull Base Tumor Program, Clinical outcomes studies and quality of Sughrue ME, Rutkowski MJ, Shangari G, Fang S, Neuro-Oncology Program, and Shunt life for meningiomas and skull Parsa AT, Berger MS, McDermott MW. Incidence, Program for Hydrocephalus in Adults. risk factors, and outcome of venous infarction after base tumors, clinical outcomes for meningioma surgery in 705 patients. J Clin Neurosci Dr. McDermott’s research includes radiosurgery treatment of benign and 2011;18(5):628-32. basic science studies related to malignant brain tumors, and he is meningiomas and novel agents for a participating research clinician in treatment. Dr. McDermott’s clinical adult glioma clinical trials at UCSF. New Faculty Internationally renowned physician- scientist Hideho Okada MD, PhD has joined the Department of Neurological Surgery to lead the new Brain Tumor Immunotherapy Center. Dr. Okada specializes in CNS immunology and will be leading the development of new brain tumor immunotherapy clinical trials at UCSF. Neuro-oncologist Jennie Taylor MD will join the UCSF Brain Tumor Center following completion of the joint Massachusetts General Hospital, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, and Harvard Medical School Neuro- Oncology Fellowship program. U.S. Defense Advanced Research Projects Agency (DARPA) Line Jacques MD will be become the Funds the Center for Neural Engineering and Prostheses at Department of Neurological Surgery’s UCSF-UC Berkeley to Develop Next-Generation Surgical new chief of peripheral nerve surgery. Devices for Neuropsychiatric Disorders In addition to fellowship training in A team of scientists and physicians • Use multisite electrode recordings peripheral nerve surgery, Dr. Jacques led by neurosurgeons Edward to create a high-resolution map of the has research interests in chronic pain. Chang MD and Philip Starr MD, human mesolimbic circuitry in both She joins UCSF from the Montreal PhD is launching a $26 million normal patients and those affected Neurological Institute and Hospital. project, funded by DARPA, to map by neuropsychiatric disorders. The Department of Neurological the human brain circuits that go • Develop an implanted device that Surgery’s Community Extension 7 awry in neuropsychiatric disorders can record spatiotemporal patterns program has grown to include two and employ advanced technology of neural activity and stimulate the new physicians. Peter Zahos MD to correct these patterns. The brain when it detects a pattern of has joined the UCSF Neurosurgery technology will improve on current abnormality consistent with the Clinic at Queen of the Valley deep brain stimulation (DBS) patient’s disorder. Medical Center in Napa Valley. devices and be applied to the neural Rishi Wadhwa MD has joined networks involved in disorders • Develop a rehabilitation training the UCSF Neurosurgery team in such as depression, anxiety, and environment for patients to use the Marin, specializing in minimally posttraumatic stress disorder. implanted device to interact with invasive and complex spine surgery. For the first time, scientists and external stimuli for cognitive training. Both physicians are available for physicians will: consultation and referrals.

Program for Caregivers of Patients with Brain Tumors Takes Off

A ribbon cutting ceremony for the of pre-determined checkpoints Neuro-Oncology Gordon Murray for interviews with the patient and Caregiver Program took place caregiver ensures that all needs are on January 16, 2014. The Neuro- being met in a timely manner. The Oncology team celebrated with goal of the program is to support active supporters of the program, caregivers so that they are prepared which provides additional support to help their loved ones through from a dedicated nurse and social the illness and, in turn, optimize the worker to family members and quality of life for patients during this caregivers of patients with difficult time. brain tumors. For more information on the Neuro- Staff members are trained to work Oncology Gordon Murray Caregiver Director of Neuro-Oncology Susan Chang MD, Randi Murray, with caregivers on specific topics at Program, visit: http://bit.ly/1y4FgHn. Margaretta Page RN, Program Coordinator Idonah Molina, and each stage of the illness. A series Neuro-Oncology Social Worker Judy Patt-Smoker in a new space dedicated for meeting with caregivers of patients with brain tumors. UCSF Department of Neurological Surgery Nonprofit Org 505 Parnassus Avenue, M779 U.S. Postage San Francisco, CA 94143-0112 PAID University of California San Francisco

selected recent publications from the department of neurological surgery

Benet A, Rincon-Torroella J, Lawton MT, González Lerner RG, Petritsch C. A microRNA-operated in TBI study [published online ahead of print Sánchez JJ. Novel embalming solution for switch of asymmetric-to-symmetric cancer stem cell April 13, 2014]. Am J Emerg Med. doi: 10.1016/j. neurosurgical simulation in cadavers. J Neurosurg divisions. Nat Cell Biol 2014;16(3):212-4. ajem.2014.04.003 2014;120(5):1229-37. Levine JM, Cohen ND, Heller M, Fajt VR, Levine Rivera LB, Bergers G. Angiogenesis. Targeting Chaumeil MM, Larson PE, Woods SM, Cai L, GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, vascular sprouts. Science 2014;344(6191):1449-50. Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Modestino A, Noble-Haeusslein LJ. Efficacy of a Ryapolova-Webb E, Afshar P, Stanslaski S, Denison Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. metalloproteinase inhibitor in spinal cord injured T, de Hemptinne C, Bankiewicz K, Starr PA. Chronic Hyperpolarized [1-13C] glutamate: a metabolic dogs. PLoS One 2014;9(5):e96408. cortical and electromyographic recordings from a imaging biomarker of IDH1 mutational status in Liu J, Wang Y, Akamatsu Y, Lee CC, Stetler RA, fully implantable device: preclinical experience in a glioma [published online ahead of print May 29, Lawton MT, Yang GY. Vascular remodeling after nonhuman primate. J Neural Eng 2014;11(1):016009. 2014]. Cancer Res. doi: 10.1158/0008-5472.CAN- ischemic stroke: mechanisms and therapeutic 14-0680. Saigal R, Lu DC, Deng DY, Chou D. Conversion of potentials. Prog Neurobiol 2014;115:138-56. high sacral to midsacral amputation via S-2 nerve Clarke JL, Molinaro AM, Phillips JJ, Butowski NA, Mesgarani N, Cheung C, Johnson K, Chang EF. preservation during partial S-2 sacrectomy for Chang SM, Perry A, Costello JF, Desilva AA, Rabbitt Phonetic feature encoding in human superior chordoma. J Neurosurg Spine 2014;20(4):421-9. JE, Prados MD. A single-institution phase II trial of temporal gyrus. Science 2014;343(6174):1006-10. radiation, temozolomide, erlotinib, and bevacizumab Salegio EA, Streeter H, Dube N, Hadaczek P, for initial treatment of glioblastoma. Neuro Oncol Morganti JM, Jopson TD, Liu S, Gupta N, Samaranch L, Kells AP, San Sebastian W, Zhai 2014;16(7):984-90. Rosi S. Cranial irradiation alters the brain’s Y, Bringas J, Xu T, Forsayeth J, Bankiewicz KS. microenvironment and permits CCR2+ macrophage Distribution of nanoparticles throughout the cerebral Hervey-Jumper SL, Berger MS. Role of surgical infiltration.PLoS One 2014;9(4):e93650. cortex of rodents and non-human primates: resection in low- and high-grade gliomas. Curr Treat Implications for gene and drug therapy. Front Options Neurol 2014;16(4):284. Noble CO, Krauze MT, Drummond DC, Forsayeth J, Neuroanat 2014;8:9. Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin Howard MA, Rubenstein JL, Baraban SC. DB, Bankiewicz KS, Park JW. Pharmacokinetics, Southwell DG, Nicholas CR, Basbaum AI, Stryker Bidirectional homeostatic plasticity induced by tumor accumulation and antitumor activity of MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A. interneuron cell death and transplantation in vivo. nanoliposomal irinotecan following systemic Interneurons from embryonic development to cell- Proc Natl Acad Sci U S A 2014;111(1):492-7. treatment of intracranial tumors [published online based therapy. Science 2014;344(6180):1240622. Jahangiri A, Aghi MK, Carbonell WS. β1 integrin: ahead of print February 4, 2014]. Nanomedicine Smith JS, Singh M, Klineberg E, et al. Surgical Critical path to antiangiogenic therapy resistance (Lond). doi:10.2217/nnm.13.201. treatment of pathological loss of lumbar lordosis and beyond. Cancer Res 2014;74(1):3-7. Potts MB, Siu JJ, Price JD, Salinas RD, Cho MJ, (flatback) in patients with normal sagittal vertical axis Johnson BE, Mazor T, Hong C, et al. Mutational Ramos AD, Hahn J, Margeta M, Oldham MC, Lim achieves similar clinical improvement as surgical analysis reveals the origin and therapy- DA. Analysis of Mll1-deficiency identifies neurogenic treatment of elevated sagittal vertical axis [published driven evolution of recurrent glioma. Science transcriptional modules and Brn4 as a factor for online ahead of print April 25, 2014]. J Neurosurg 2014;343(6167):189-93. direct astrocyte-to-neuron reprogramming [published Spine. doi: 10.3171/2014.3.SPINE13580 online ahead of print May 30, 2014]. Neurosurgery. Lemmon VP, Ferguson AR, Popovich PG, et al. Tran M, Wadhwa R, Ziewacz J, Mummaneni P, Chou doi: 10.1227/NEU.0000000000000452 Minimum Information About a Spinal Cord Injury D. Comparison between C1-2 fixation with and Experiment (MIASCI) - a proposed reporting Ratcliff JJ, Adeoye O, Lindsell CJ, Hart KW, Pancioli without supplemental posterior wiring. Evid Based standard for spinal cord injury experiments A, McMullan JT, Yue JK, Nishijima DK, Gordon Spine Care J 2014;5(1):12-5. [published online ahead of print May 28, 2014]. WA, Valadka AB, Okonkwo DO, Lingsma HF, Maas Walsh KM, Codd V, Smirnov IV, et al. Variants near J Neurotrauma. doi: 10.1089/neu.2014.3400 AI, Manley GT; For the TRACK-TBI investigators. TERT and TERC influencing telomere length are ED disposition of the Glasgow Coma Scale 13 to associated with high-grade glioma risk. Nat Genet 15 traumatic brain injury patient: analysis of the Editor: Ilona Garner ([email protected]) 2014;46(7):731-5. Transforming Research and Clinical Knowledge Design & layout: Aqua Design Studio For information on supporting the Department, contact the office of Development at (415) 476-0506.